Massachusetts Institute Of Technology

ALCATOR C-MOD FUSION RESEARCH PROGRAM

UNITED STATES AIR FORCE (USAF) ARTIFICIAL INTELLIGENCE (AI) ACCELERATOR AT THE MASSACHUSETTS INSITUTE OF TECHNOLOGY (MIT)

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

TAS::89 0227: :TAS RECOVERY ACT ALCATOR C-MOD FUSION RESEARCH PROGRAM

BROAD INSTITUTE COMPREHENSIVE SCREENING CENTER

GRADUATE RESEARCH FELLOWSHIP PROGRAM

LABORTORY FOR NUCLEAR SCIENCE (BATES CERN-L3)

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

CANCER CENTER SUPPORT (CORE) GRANT

MIT PLASMA SCIENCE AND FUSION CENTER MAGNETIC CONFINEMENT FUSION EXPERIMENT RESEARCH AND RELATED ACTIVITIES

ARPA-H OPEN BAA 2023

LABORATORY FOR NUCLEAR SCIENCE - HIGH ENERGY PHYSICS PROGRAM

RESEARCH IN NUCLEAR PHYSICS

TAS::89 0227::TAS RECOVERY; RECOVERY ACT - CENTER FOR EXCITONICS -- EFRC; PI - MARC BALDO

A CENTER FOR BRAINS, MINDS AND MACHINES: THE SCIENCE AND THE TECHNOLOGY OF INTELLIGENCE

NSF SCIENCE AND TECHNOLOGY CENTER: EMERGENT BEHAVIORS OF INTEGRATED CELLULAR SYSTEMS

AMS OPERATIONS

NEW: SOLID-STATE SOLAR-THERMAL ENERGY CONVERSION CENTER (S3TEC CENTER) -- EFRC; PI - GANG CHEN

LABORATORY FOR NUCLEAR SCIENCE - HIGH ENERGY PHYSICS PROGRAM

HIGHER EDUCATION SOLUTIONS NETWORK (HESN)

BARRIER-IMMUNE-ORGAN: MICROPHYSIOLOGY, MICROENVIRONMENT ENGINEERED TISSUE CONSTRUCT SYSTEMS (BIO-MIMETICS)

GRADUATE RESEARCH FELLOWSHIP PROGRAM

THIS PROJECT CONTINUES DEVELOPMENT OF A NOISE ANALYSIS METHOD WITH IMPROVED FIDELITY, ACCURACY, AND UTILITY FOR EVALUATION OF ADVANCED OPERA

THEORETICAL RESEARCH IN ADVANCED PHYSICS AND TECHNOLOGY

AMS RESEARCH

PRE-DOCTORAL GRANT IN THE BIOLOGICAL SCIENCES

ISN 4 - COLLABORATIVE AGREEMENT

TASK Q - RELATIVISTIC HEAVY ION GROUP (RHIG) FY14-16

AI INSTITUTE: AI RESEARCH INSTITUTE FOR FUNDAMENTAL INTERACTIONS

MIT MATERIALS RESEARCH SCIENCE AND ENGINEERING CENTER (MRSEC)

BATES RESEARCH & ENGINEERING CENTER, TASK L, 3 YEAR FY 2017-19

SCIENCE AND ENGINEERING FOR SENSORS, MECHANISMS, AND BIOMARKERS OF EXPOSURES

THIS COOPERATIVE AGREEMENT SHALL BE PERFORMED IN ACCORDANCE WITH STATEMENT OF WORK, ENTITLED "INGESTIBLE TRANSCEIVER-ACTUATABLE RESIDENT GASTROINTESTI

LABORTORY FOR NUCLEAR SCIENCE (BATES CERN-L3)

CHARACTERIZATION OF PATHWAYS CONTROLLING CANCER AT THE LEVEL OF GENE REGULATION

THE CENTER FOR ENHANCED NANOFLUIDIC TRANSPORT (CENT)

AN INTEGRATED FRAMEWORK FOR CLIMATE CHANGE ASSESSMENT

MIT MATERIALS RESEARCH SCIENCE AND ENGINEERING CENTER - FULL PROPOSAL

MIT CENTER FOR ENVIRONMENTAL HEALTH SCIENCES

FUSION DEVELOPMENT & TECHNOLOGY

REGULATORY NETWORKS IN CANCER INITIATION AND PROGRESSION

SYSTEMS BIOLOGY OF CELL DECISION PROCESSES

EXTRAMURAL RESEARCH FACILITIES IMPROVEMENT PROGRAM

TAS::57 3600::TAS OPTIMAL MEASUREMENTS FOR SCALABLE QUANTUM TECHNOLOGIES

THE MIT CENTER FOR SINGLE-CELL DYNAMICS IN CANCER (SCDC)

CENTER FOR ULTRACOLD ATOMS

GRANT

COOPERATIVE AGREEMENT AWARD

FUSION DEVELOPMENT AND TECHNOLOGY

ENDOGENOUS NITRITE CARCINOGENESIS IN MAN

FY 2014-2016 TASK R - THEORETICAL NUCLEAR PHYSICS

CENTER FOR ULTRACOLD ATOMS

AUTOMATED SYSTEM FOR KNOWLEDGE-BASED CONTINUOUS ORGANIC SYNTHESIS (ASKCOS)

CENTER: CENTER FOR ULTRACOLD ATOMS -UNDERSTANDING, CONTROLLING, AND HARNESSING INCREASINGLY COMPLEX MANY-BODY QUANTUM SYSTEMS IS AN IMPORTANT FRONTIER OF SCIENCE, AND IS ESSENTIAL FOR THE DEVELOPMENT OF NEW MATERIALS AND THE ADVANCE OF QUANTUM INFORMATION SCIENCE. ELUCIDATING HOW MICROSCALE PHYSICS DETERMINES THE MACROSCALE BEHAVIOR OF QUANTUM SYSTEMS IS ONE OF THE GRAND, OPEN QUESTIONS OF MODERN SCIENCE AND A PHYSICS FRONTIER. THE CENTER FOR ULTRACOLD ATOMS (CUA) IS A JOINT EFFORT BETWEEN THE MASSACHUSETTS INSTITUTE OF TECHNOLOGY AND HARVARD UNIVERSITY WITH THE GOAL OF CREATING, CONTROLLING, AND STUDYING INTENTIONAL COMPLEXITY IN QUANTUM SYSTEMS. THE CUA ADDRESSES THIS FUNDAMENTAL CHALLENGE IN A COLLABORATIVE AND SYNERGISTIC MANNER, USING SYSTEMS WHERE THE PROPERTIES AND INTERACTIONS OF PARTICLES AT THE MICROSCOPIC SCALE ARE WELL UNDERSTOOD, ACCURATELY QUANTIFIED, AND HIGHLY CONTROLLABLE AT THE QUANTUM LEVEL. THE CUA WILL ALSO ADVANCE EDUCATION AND OUTREACH WITH A BROAD PORTFOLIO OF ACTIVITIES AIMED AT BOTH THE SCIENTIFIC COMMUNITY AND THE GENERAL PUBLIC. THE CORE OUTREACH PROGRAM, ENGAGECUA, EXTENDS PARTICIPATION IN THESE ACTIVITIES TO THE WHOLE CUA COMMUNITY. THE CUA RESEARCH ACTIVITIES ARE DIVIDED INTO FOUR MAJOR AREAS. THE FIRST AREA FOCUSES ON QUANTUM GASES OF ATOMS AND MOLECULES AND AIMS AT EXPANDING CONTROL OVER MANY-BODY SYSTEMS IN MULTIPLE DIRECTIONS, INCLUDING LONG-RANGE FORCES AND NOVEL GEOMETRIES (BILAYER SYSTEMS, FRUSTRATED LATTICES, GAUGE FIELDS). THE SECOND AREA IS PROGRAMMABLE ARRAYS OF RYDBERG ATOMS AND MOLECULES. THEY WILL BE USED TO EXPLORE HIGHLY-ENTANGLED PHASES OF MATTER, TO PERFORM FUNDAMENTAL RESEARCH ON ERROR CORRECTION, AND TO PURSUE NEW APPLICATIONS, E.G., TO QUANTUM CHEMISTRY. THE THIRD AREA EXPLOITS ATOM-LIKE AND HYBRID SYSTEMS, INCLUDING SPIN DEFECTS AND TRAPPED ELECTRONS AND EXCITONS IN TWO-DIMENSIONAL GEOMETRIES. THESE SOLID-STATE SYSTEMS WILL ENABLE QUANTUM SIMULATIONS WITH STRONG INTERACTIONS AND NEW APPLICATIONS IN SENSING AND METROLOGY. THE FOURTH AREA FOCUSES ON STRONGLY COUPLED ATOMS AND PHOTONS. THE LARGER GOAL IS TO ENABLE NEW CAPABILITIES FOR ENGINEERING MANY-BODY STATES OF ATOMS AND PHOTONS, WITH APPLICATIONS IN QUANTUM NONLINEAR OPTICS, QUANTUM METROLOGY, AND NETWORKING. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

MATERNAL OMICS TO MAXIMIZE IMMUNITY - OVERALL: SUMMARY FROM THE MOMENT OF FERTILIZATION TO BIRTH, THE MATERNAL IMMUNE SYSTEM EVOLVES, ADAPTS, AND SUPPORTS THE GROWTH OF A FETAL ALLOGRAFT THAT ULTIMATELY PERPETUATES THE HUMAN RACE. IMMUNOLOGICAL CHANGES THROUGHOUT A PREGNANCY PLAY A KEY DETERMINISTIC ROLE IN THE SUCCESS OF THE PREGNANCY. WHILE PREGNANCY WAS HISTORICALLY REGARDED AS A SIMPLE SHIFT TOWARDS TOLERANCE, EMERGING IMMUNOLOGICAL DATA POINT TO REMARKABLE DYNAMIC CHANGES DURING PREGNANCY. THE PREGNANCY IMMUNOME MUST PROTECT THE FETUS FROM A MATERNAL ATTACK WHILE AT THE SAME TIME IT MUST AFFORD THE MATERNAL-FETAL DYAD PROTECTION FROM INVADING PATHOGENS. THE HEALTH OF THE MOTHER AND THE FETUS REQUIRES THAT THESE TWO OPPOSING IMMUNOLOGICAL TASKS WORK IN CONCERT. THUS COLLECTIVELY, PREGNANCY MARKS A WHIRLWIND OF IMMUNE ADAPTATIONS THAT RENDER THE PREGNANT IMMUNE SYSTEM A TRULY UNIQUE IMMUNOLOGIC MARVEL. DESPITE OUR GROWING APPRECIATION FOR THESE HIGHLY CONTROLLED DYNAMIC SHIFTS, THE PRECISE MECHANISMS THAT LEAD TO OPTIMAL PREGNANCY HEALTH, PROFOUNDLY IMPACTING BOTH MOTHER AND FETUS, ARE INCOMPLETELY UNDERSTOOD, DELAYING THE DEVELOPMENT OF TARGETED THERAPIES FOR THIS POPULATION. CAPITALIZING ON THIS UNIQUE MOMENT IN VACCINE HISTORY, WITH THE INTRODUCTION OF SEVERAL NOVEL-VACCINE PLATFORMS FOR SARS-COV-2, THE CONSORTIUM WILL BUILD A PREGNANCY IMMUNE ATLAS VIA THE APPLICATION OF HIGH-DENSITY IMMUNOLOGICAL PROFILING TECHNOLOGIES TO DEEPLY AND COMPREHENSIVELY DISSECT THE OVERALL CHANGES THAT OCCUR ACROSS PREGNANCY AND HOW THE IMMUNE SYSTEM, AS A COLLECTIVE, RESPONDS TO IN VIVO PERTURBATIONS WITH VACCINES. USING BOTH DE NOVO VACCINE INDUCED IMMUNE RESPONSES AND BOOSTER VACCINATION, THE CONSORTIUM WILL CAPTURE OVERALL CHANGES IN THE PREGNANT IMMUNOME AS WELL AS SHIFTS IN THE PREGNANT ADAPTOME TO FULLY CAPTURE THE IMMUNOLOGICAL MECHANISMS THAT GOVERN THE BALANCED GROWTH OF THE FETUS AND BATTLE OF THE MATERNAL:FETAL DYAD AGAINST INVADING PATHOGENS. THUS, TOGETHER THE MATERNAL ‘OMICS TO MAXIMIZE IMMUNITY (MOMI) CONSORTIUM SEEKS TO BUILD THE FOUNDATIONAL DATA TO ADVANCE OUR KNOWLEDGE OF NATURAL TOLERANCE, FERTILITY, SHIFTS IN IMMUNITY DURING PREGNANCY TO BETTER UNDERSTAND THIS EVOLUTIONARY MARVEL REQUIRED FOR THE PERPETUATION OF THE HUMAN SPECIES.

SISGR - CHEMOMECHANICS OF FAR-FROM-EQUILIBRIUM INTERFACES (COFFEI)

CENTER FOR MAGNETIC RESONANCE

SCIENTIFIC AND TECHNICAL DISCOVERY AT THE MILLSTONE HILL GEOSPACE FACILITY

CENTER FOR MULTI-SCALE MULTI-OMIC HUMAN AND NON-HUMAN PRIMATE BRAIN ATLAS - PROJECT SUMMARY A DETAILED UNDERSTANDING OF THE FUNCTIONAL, ANATOMICAL AND MOLECULAR ARCHITECTURES OF BRAIN CELLS AND THEIR BRAIN-WIDE ORGANIZATION IS ESSENTIAL FOR INTERROGATING NORMAL HUMAN BRAIN FUNCTION AND DISEASE STATES. EXTENSIVE EFFORTS HAVE BEEN MADE TOWARD MAPPING BRAIN CELLS THROUGH VARIOUS APPROACHES, RESULTING IN INVALUABLE DATABASES THAT ARE YIELDING NEW INSIGHTS. HOWEVER, WE STILL LACK COMPREHENSIVE HUMAN BRAIN ATLASES THAT CAPTURE MULTI-LEVEL PROPERTIES OF INDIVIDUAL CELLS WHILE ADEQUATELY REPRESENTING HUMAN DEMOGRAPHIC DIVERSITY AND INDIVIDUAL VARIABILITY. THE GOAL OF THIS PROPOSAL IS TO CREATE FULLY INTEGRATED THREE-DIMENSIONAL (3D) HUMAN AND NON-HUMAN PRIMATE (NHP) BRAIN CELL ATLASES AT SUBCELLULAR RESOLUTION BY SIMULTANEOUSLY MAPPING BRAIN-WIDE FUNCTION, STRUCTURE, AND HIGH-DIMENSIONAL FEATURES (E.G., PROTEOMIC, TRANSCRIPTOMIC, SPATIAL, MORPHOLOGICAL, MICROENVIRONMENT AND NANOSCOPIC INFORMATION) OF CELLS ACQUIRED FROM THE SAME WHOLE BRAINS WITH COMPLETE COVERAGE OF ALL BRAIN REGIONS. OUR TEAM WILL ACCOMPLISH THIS BY SEAMLESSLY INTEGRATING MULTIMODAL DATA FROM STATE-OF-THE-ART FUNCTIONAL (FOR NHP BRAINS), STRUCTURAL, DIFFUSION MRI, AND MULTISCALE 3D PROTEOMIC/TRANSCRIPTOMIC IMAGING TECHNOLOGIES. USING THE SCALABLE TECHNOLOGY PIPELINES, WE WILL PERFORM PROTEOMIC AND TRANSCRIPTOMIC IMAGING OF (1) HUMAN BRAINS ACQUIRED FROM A LARGE NUMBER OF DEMOGRAPHICALLY REPRESENTATIVE DONORS AND (2) FUNCTIONALLY CHARACTERIZED NON-HUMAN PRIMATE BRAINS. THE PROPOSED WORK WILL CREATE THE MOST COMPREHENSIVE 3D HUMAN AND NHP BRAIN ATLASES TO DATE, WITH UNPRECEDENTED RESOLUTION AND COMPLETENESS. THE ATLASES WILL ESTABLISH INTER-SPECIES HOMOLOGIES ESSENTIAL FOR THE TRANSLATION OF INSIGHTS DERIVED FROM ANIMAL MODELS TO HUMANS, AND AID IN IDENTIFYING THE CELLULAR AND MOLECULAR UNDERPINNINGS OF HUMAN COGNITION AND SUSCEPTIBILITY TO DISEASE. ADDITIONALLY, THE UNPRECEDENTED, MULTISCALE MULTI-OMIC DATASETS ACQUIRED FROM A LARGE NUMBER OF DEMOGRAPHICALLY REPRESENTATIVE HUMAN DONORS WILL ENABLE POPULATION LEVEL INTER-INDIVIDUAL VARIATION STUDY AND ALLOW BASELINE CHARACTERIZATION OF CELLULAR AND SUBCELLULAR FEATURES, PROVIDING AN IMMEDIATELY USEFUL REFERENCE FRAME FOR THE RESEARCH COMMUNITY TO STUDY DISEASE-SPECIFIC CHANGES IN CELL COMPOSITION, SPATIAL DISTRIBUTION, AND SUBCELLULAR ARCHITECTURES. FINALLY, OUR TEAM WILL WORK CLOSELY WITH EXISTING BICAN CENTERS TO MAXIMIZE SYNERGY AND UTILIZATION OF SCARCE BRAIN MATERIALS AND ENABLE TRUE MULTIMODAL DATA INTEGRATION.

TASK A: PARTICLE PHYSICS COLLABORATION

DANDI: DISTRIBUTED ARCHIVES FOR NEUROPHYSIOLOGY DATA INTEGRATION

METAL-CATALYZED METHODS FOR ORGANIC SYNTHESIS

TAS::57 3600::TAS "(MURI-2013) ADVANCED QUANTUM MATERIALS - A NEW FRONTIER FOR ULTRACOLD ATOMS"

MIT-HARVARD CENTER OF CANCER NANOTECHNOLOGY EXCELLENCE

MIT LASER BIOMEDICAL RESEARCH CENTER (P41-RR02594)

THE MILLSTONE HILL GEOSPACE FACILITY

NEW TREATMENTS FOR STRESS-INDUCED DYSREGULATION OF CIRCUITS REGULATING REWARD FEAR AND HABIT LEARNING

MIT CENTER FOR INTEGRATIVE SYNTHETIC BIOLOGY

SOLAR MAXIMUM STUDIES AT THE MILLSTONE HILL OBSERVATORY

BUILDING RESEARCH AND INNOVATION FOR DEVELOPMENT, GENERATING EVIDENCE, AND TRAINING (BRIDGE-TRAIN) UNDER EXISTING SCIENCE, TECHNOLOGY, INNOVATION, AND PARTNERSHIP ANNUAL PROGRAM STATEMENT APS NO.: 7200AA18APS00003

MIT/MAYO PHYSICAL SCIENCES CENTER FOR DRUG DISTRIBUTION AND EFFICACY IN BRAIN TUMORS

QUANTITATIVE AND FUNCTIONAL CHARACTERIZATION OF THERAPEUTIC RESISTANCE IN CANCER

CENTER FOR ADVANCED NUCLEAR DIAGNOSTICS AND PLATFORMS FOR ICF AND HED PHYSICS AT OMEGA, NIF AND Z BASE AWARD FOR YEAR 1 IS FULLY FUNDED.

MIT SEA GRANT OMNIBUS 2018-2022

MULTI-QUBIT ENHANCED SENSING & METROLOGY

ECIR - EXPLORATIONS IN CYBER INTERNATIONAL RELATIONS

TRAINING GRANT IN ENVIRONMENTAL TOXICOLOGY

ELECTRONIC-PHOTONIC HETEROGENEOUS INTEGRATION (E-PHI)

CENTER FOR CO-DESIGN OF DURABLE, REPRODUCIBLE, AND EFFICIENT PEROVSKITE TANDEMS A. PROJECT OBJECTIVES OVERALL PROJECT OBJECTIVES: THIS CENTER WILL EMPOWER INDUSTRY TO ACHIEVE SETO’S PEROVSKITE MODULE TARGETS VIA A FUNDAMENTALLY DIFFERENT PATH. INSTEAD OF CHASING RECORD EFFICIENCIES WITH TINY PIXEL-SIZED DEVICES, AND LATER ATTEMPTING TO STABILIZE THEM, THIS CENTER EMBRACES A “CO-DESIGN” APPROACH THAT SIMULTANEOUSLY TARGETS COMBINATIONS OF TECHNOECONOMIC PARAMETERS INCLUDING STABILITY, REPRODUCIBILITY, AND EFFICIENCY.

THEORETICAL HIGH ENERGY PHYSICS

QUANTUM EMULATIONS OF NEW MATERIALS USING ULTRACOLD ATOMS

EXPERIMENTAL AND THEORETICAL RESEARCH IN APPLIED PLASMA PHYISCS

BRAIN CONNECTS: COMPREHENSIVE REGIONAL PROJECTION MAP OF MARMOSET WITH SINGLE AXON AND CELL TYPE RESOLUTION - SUMMARY THIS AMBITIOUS PROPOSAL WILL ESTABLISH AN INTEGRATED EXPERIMENTAL-COMPUTATIONAL PLATFORM TO CREATE THE FIRST COMPREHENSIVE BRAIN-WIDE MESOSCALE CONNECTIVITY MAP IN A NON-HUMAN PRIMATE, THE COMMON MARMOSET (CALLITHRIX JACCHUS),. IT WILL DO SO BY TRACING AXONAL PROJECTIONS OF RNA BARCODE-IDENTIFIED NEURONS BRAIN-WIDE IN THE MARMOSET, UTILIZING A SEQUENCING-BASED IMAGING METHOD THAT ALSO PERMITS SIMULTANEOUS TRANSCRIPTOMIC CELL TYPING OF THE IDENTIFIED NEURONS. THIS WILL HELP BRIDGE THE GAP BETWEEN BRAIN-WIDE MESOSCALE CONNECTIVITY DATA AVAILABLE FOR THE MOUSE FROM A DECADE OF MAPPING EFFORTS USING MODERN TECHNIQUES AND THE ABSENCE OF COMPARABLE DATA IN HUMANS AND NHP. THE PROPOSAL WILL BRING TOGETHER NEW VIRAL BARCODE-BASED APPROACHES WITH ESTABLISHED TRACER-INJECTION BASED METHODS TO COLLECT AN UNPRECEDENTED DATA SET WHICH WILL PERMIT COMPREHENSIVE MAPPING OF REGION-TO-REGION AXONAL PROJECTIONS IN THE MARMOSET BRAIN WITH CELL-TYPE SPECIFICITY, APPLY THIS DATA TO SCIENTIFIC QUESTIONS REGARDING HOW BRAIN CONNECTIVITY DIFFERS BETWEEN PRIMATES AND RODENTS, ADDRESS THE RELATION BETWEEN MRI-DERIVED MEASURES TO GROUND-TRUTH CONNECTIVITY, AND UTILIZE WEB-BASED TOOLS TO ENGAGE THE RESEARCH COMMUNITY IN ANNOTATING AND USING THE RESULTING DATA. A DIVERSE TEAM OF WORLD-LEADING EXPERTS AND PIONEERS IN THE PROBLEM DOMAIN WHO ARE ALREADY COLLABORATING, SPANNING DIVERSE INSTITUTIONS AND DISCIPLINES, AND EQUIPPED WITH OUTSTANDING FACILITIES AND RESOURCES, WILL COME TOGETHER TO ASSEMBLE THE ENABLING PLATFORM. THERE ARE FIVE SPECIFIC AIMS TO ACHIEVE STATED GOALS. AIM 1 IS TO ESTABLISH DATA ACQUISITION PLATFORM FOR MESOSCALE PROJECTION MAPPING IN MARMOSET USING BARCODED + FLUORESCENT AAV/AAV-RETRO. AIM 2 IS TO DEVELOP BRAIN-WIDE SINGLE-AXON PROJECTION MAPS USING SYSTEMIC INJECTIONS WITH SIMULTANEOUS TRANSCRIPTOMIC CELL-TYPING. AIM 3 IS TO DEVELOP DATA MANAGEMENT AND ANALYSIS PIPELINES. AIM 4 IS TO PERFORM COMPARATIVE STUDIES OF THE MESOSCALE CONNECTIVITY IN MARMOSET AND MOUSE, COMPARING MRI-BASED CONNECTIVITY WITH GROUND TRUTH. AIM 5 IS TO DEVELOP PLATFORMS FOR DATA DISSEMINATION, COMMUNITY ENGAGEMENT THROUGH WEB PORTAL, COLLABORATIVE PROOFREADING AND ANNOTATIONS. SUCH A DATA SET WILL HAVE PROFOUND SCIENTIFIC SIGNIFICANCE, COMPARABLE TO THE FIRST WHOLE GENOME MAP OF A PRIMATE. AS GENOMES ENCODE THE BLUEPRINT FOR UNDERSTANDING AN ORGANISM’S PHENOTYPE, SO DOES THE ARCHITECTURE OF BRAIN CIRCUITRY CONTAIN THE BLUEPRINT FOR EXPLAINING AN ANIMAL’S BEHAVIOR AND HOLDS THE KEY TO MANY OPEN QUESTIONS.

HIGHER EDUCATION EMERGENCY RELIEF FUNDS II - STUDENT AID UNDER THE CORONAVIRUS RESPONSE AND RELIEF SUPPLEMENTAL APPROPRIATION ACT, 2021

PROJECT PRAKASH: DEVELOPMENT OF OBJECT PERCEPTION AFTER LATE SIGHT ONSET

TAS::89 0336::TAS RECOVERY THIS PROJECT TARGETS RADICAL IMPROVEMENTS IN THE SIZE, INTEGRATION AND PERFORMANCE OF POWER ELECTRONICS FOR HIGH-EFFICI

TOWARDS INTEGRATED 3D RECONSTRUCTION OF WHOLE HUMAN BRAINS AT SUBCELLULAR RESOLUTION

CORE - VISION PROCESSIES

3D MODELS OF ENGINEERED HUMAN IPS CELLS TO INVESTIGATE NEUROTROPIC VIRUS INFECTIONS

THE MIT-HARVARD CENTER OF CANCER NANOTECHNOLOGY EXCELLE*

BACTERIAL PROTEIN TAGGING, DEGRADATION AND RIBOSOME RESCUE

WE PROPOSE THE CREATION OF A SINGLE-DISCIPLINE CENTER (SDC) FOR THE EXASCALE SIMULATION OF MATERIALS IN HYPERSONIC FLOW ENVIRONMENTS. OUR OBJECTIVES ARE AS FOLLOWS. FIRST, WE TARGET A SIGNIFICANT ADVANCE IN THE ABILITY TO PREDICT THE DEGRADATION (OXIDATION AND MELTING) OF COMPLEX (DISORDERED AND MULTI-COMPONENT) MATERIALS UNDER EXTREME LOADING, INACCESSIBLE TO DIRECT EXPERIMENTAL OBSERVATION. THIS APPLICATION REPRESENTS A TECHNOLOGY DOMAIN OF INTENSE CURRENT INTEREST, AND HAS CLEAR EXTENSIONS TO A MUCH WIDER CLASS OF PROBLEMS— I.E., THOSE INVOLVING MATERIAL INTERFACES IN EXTREME ENVIRONMENTS. INDEED, INTERFACES ARE CRUCIAL TO OUR ABILITY TO UNDERSTAND, ENGINEER, AND CONTROL MATERIAL BEHAVIOR. YET THE PREDICTIVE SIMULATION OF INTERFACE PROPERTIES AND THEIR IMPACT REMAINS EXTREMELY CHALLENGING. CAPTURING THE IMPACT OF INTERFACES REQUIRES RESOLVING INTERFACIAL ATOMIC STRUCTURE AND THUS APPEALING TO FIRST PRINCIPLES (I.E., QUANTUM MECHANICAL) SIMULATIONS; AT THE SAME TIME, INTERFACIAL STRUCTURES ARE AFFECTED BY CONDITIONS (E.G., THERMAL, MECHANICAL, AND CHEMICAL LOADING) AT THE ENGINEERING SCALE. THIS PROBLEM THUS PRESENTS AN ENORMOUS AND FUNDAMENTAL MULTISCALE SIMULATION CHALLENGE, WITH MYRIAD APPLICATIONS—TO HYPERSONICS AND FAR BEYOND.

CENTER FOR ULTRACOLD ATOMS

MECHANICAL DETERMINANTS OF ORGAN-SELECTIVE METASTATIC COLONIZATION, DORMANCY AND OUTGROWTH - OVERALL: PROJECT SUMMARY METASTATIC DISEASE IS RESPONSIBLE FOR THE VAST MAJORITY OF CANCER MORTALITY. UNDERSTANDING OF THE FUNDAMENTAL MECHANISMS LEADING TO METASTATIC CANCER HAS BEEN HAMPERED BY THE NEED FOR MODELS THAT REPLICATE THE STEP- WISE METASTATIC PROCESS IN VIVO, YET ARE AMENABLE TO TIGHT CONTROL AND FACILITATE HIGH-RESOLUTION, TIME-LAPSE IMAGING AND QUANTITATIVE ANALYSIS OF CELL BEHAVIOR. OVER THE PAST DECADE, OUR TEAM HAS DEVELOPED IN VIVO AND IN VITRO METHODS CAPABLE OF SIMULATING MANY STEPS OF THE METASTATIC CASCADE INCLUDING TUMOR CELL INVASION, INTRAVASATION, TRAPPING IN THE MICROCIRCULATION OR ADHESION TO THE VESSEL WALLS, AND EXTRAVASATION INTO THE SURROUNDING EXTRACELLULAR MATRIX. IN PARALLEL, WE HAVE DEVELOPED COMPUTATIONAL STUDIES THAT PROVIDED DETAILED INSIGHTS OFTEN NOT POSSIBLE THROUGH EXPERIMENTS. THIS COLLECTIVE PRIOR WORK HAS SHED NEW LIGHT ON CENTRAL ASPECTS OF SINGLE-CELL AND COLLECTIVE CELL BEHAVIOR DURING METASTASIS, AND IDENTIFIED MECHANICAL ADAPTATIONS AND VULNERABILITIES OF THE TUMOR CELL WITH PROMISE FOR TARGETED INTERVENTIONS. THE GOAL OF OUR PROPOSED U54 CENTER IS TO EMPLOY THESE DEVELOPED ASSAYS AND METHODS IN COMBINATION WITH NEW MEASUREMENT TECHNIQUES TO INTERROGATE THE FULL SPECTRUM OF STRESSORS EXPERIENCED BY TUMOR CELLS IN THE METASTATIC NICHE DURING ARREST AND EXTRAVASATION, AND COUPLE THESE WITH PARALLEL STUDIES OF CHANGES IN CHROMATIN STRUCTURE AND THE TRANSCRIPTOME OF TUMOR CELLS (CORE B). THESE CHANGES ARE CRITICAL TO MECHANO-ADAPTATION OF THE TUMOR CELLS TOWARDS AN ORGAN-PREFERENTIAL INITIATION OF A METASTATIC COLONY OR TRANSITION TO DORMANCY. A HALLMARK OF OUR PROPOSED CENTER IS THE USE OF STATE- OF-THE-ART IN VITRO (PROJECT 1) AND IN VIVO (PROJECT 2) EXPERIMENTS AND COMPUTATION (CORE A) TO UNCOVER AND PROBE THE FACTORS THAT ULTIMATELY DETERMINE TUMOR CELL FATE. WE ANTICIPATE THAT SUCH INTEGRATED STUDIES WILL PROVIDE NEW INSIGHTS INTO METASTATIC CANCER, NOT POSSIBLE BY THE USE OF ANY METHOD ALONE, AND ENHANCE OUR ABILITY TO IDENTIFY AND SCREEN FOR NEW THERAPIES TO INHIBIT THE TENDENCY FOR METASTATIC SPREAD OF DISEASE.

MIT SEA GRANT OMNIBUS PROPOSAL

REQUIREMENTS FOR THE DEVELOPMENT AND MAINTENANCE OF MULTICELLULAR LIFE IN RESPONSE TO CAN #NNH05ZDA001C, NASA ASTROBIOLOGY INSTITUTE - CYCLE 4 NEW CO

INTERDEPARTMENTAL BIOTECHNOLOGY TRAINING PROGRAM

MIT SEA GRANT OMNIBUS PROPOSAL 2014

MOLECULAR ANALYSIS OF CARDIOVASCULAR BIOLOGY AND PATHOLOGY

PRE-DOCTORAL TRAINING IN FUNDAMENTAL APPROACHES TO BIOCHEMISTRY AND CELL AND MOLECULAR BIOLOGY - THIS PROPOSAL IS FOR SUPPORT OF THE PRE-DOCTORAL PROGRAM IN CELLULAR, BIOCHEMICAL AND MOLECULAR SCIENCE AT THE MASSACHUSETTS INSTITUTE OF TECHNOLOGY (MIT). OUR MISSION IS TO TRAIN THE NEXT GENERATION OF BIOLOGICAL/BIOMEDICAL SCIENTISTS, MANY OF WHOM WILL BE INNOVATORS AND LEADERS IN RESEARCH, EDUCATION, AND OTHER FIELDS. THIS PROPOSAL BUILDS ON AN OUTSTANDING TRAINING RECORD DEVELOPED OVER A 46-YEAR PARTNERSHIP WITH NIGMS. OUR AIMS ARE TO: EDUCATE STUDENTS TO UNDERSTAND THE FUNDAMENTAL AND UNDERLYING PRINCIPLES OF MOLECULAR, BIOCHEMICAL, AND CELLULAR BIOLOGY, TRAIN STUDENTS TO BE CRITICAL AND CREATIVE THINKERS, PREPARE STUDENTS TO BE ETHICAL DECISION MAKERS, TEACH AND PROVIDE PRACTICE IN WRITTEN AND ORAL COMMUNICATION, PROVIDE EXPERIENCE WITH TEACHING AND MENTORING YOUNGER STUDENTS, MENTOR STUDENTS TO BECOME EFFECTIVE AND RIGOROUS RESEARCHERS, GUIDE STUDENTS THROUGH COMPLETION AND PUBLICATION OF RESEARCH PROJECTS, ADVISE STUDENTS AS THEY DETERMINE THE BEST-FIT CAREERS FOR THEIR INTERESTS AND SKILLS, PROVIDE AN INCLUSIVE LEARNING AND RESEARCH ENVIRONMENT, AND BROADEN PARTICIPATION OF INDIVIDUALS WITH DIVERSE BACKGROUNDS IN BIOMEDICAL RESEARCH CAREERS. WE RECRUIT AND TRAIN TALENTED STUDENTS FROM MAJORITY, UNDERREPRESENTED MINORITY, DISABLED, AND DISADVANTAGED POPULATIONS. TRAINEES ADMITTED TO OUR PROGRAM HAVE OUTSTANDING ACADEMIC RECORDS AND STRONG MOTIVATION AND APTITUDE TO PURSUE RESEARCH. A KEY FEATURE OF OUR PROGRAM IS AN INTENSIVE, FOCUSED CURRICULUM REQUIRED OF ALL FIRST-YEAR STUDENTS. STUDENTS WORK TOGETHER IN LECTURE AND DISCUSSION-STYLE COURSES TAUGHT BY DEDICATED FACULTY TO MASTER A FUNDAMENTAL SET OF APPROACHES THAT UNDERPIN MOLECULAR BIOLOGICAL SCIENCE. THE TRAINING PROGRAM EXPOSES STUDENTS TO THE RESEARCH INTERESTS OF ALL FACULTY MEMBERS IN THE BIOLOGY DEPARTMENT PRIOR TO A SEQUENCE OF ROTATIONS THAT, IN COMBINATION WITH FIRST-SEMESTER COURSES, SUPPORT AN INFORMED CHOICE OF A THESIS ADVISOR AND TOPIC. STUDENTS GAIN EXPERIENCE IN SCIENTIFIC COMMUNICATION AND IN TEACHING AND MENTORING JUNIOR STUDENTS. RESPONSIBLE CONDUCT OF RESEARCH IS TAUGHT IN BOTH CLASSROOM AND LABORATORY SETTINGS, INCLUDING AN INTENSE MINI-COURSE FOR 2ND YEAR STUDENTS. STUDENTS HAVE MANY OPPORTUNITIES TO LEARN ABOUT CAREER PATHS OPEN TO THEM FOLLOWING DOCTORAL TRAINING. STUDENTS’ PROGRESS THROUGH THE PROGRAM IS MONITORED IN REGULAR THESIS COMMITTEE MEETINGS WITH FACULTY MEMBERS, WITH OVERSIGHT BY THE GRADUATE COMMITTEE. WE SEEK TO BUILD AND MAINTAIN A WELCOMING AND SUPPORTIVE COMMUNITY IN WHICH ALL STUDENTS ARE VALUED AND INCLUDED. THIS TRAINING GRANT WOULD CONSTITUTE A CRITICAL SOURCE OF SUPPORT FOR ~50% OF TRAINING-GRANT ELIGIBLE GRADUATE STUDENTS IN OUR PROGRAM DURING THEIR FIRST TWO YEARS. OUR STUDENTS PERFORM RESEARCH OF OUTSTANDING QUALITY, AND MOST TRAINEES GO ON TO CAREERS IN BIOMEDICAL RESEARCH. MANY OF OUR FORMER TRAINEES ARE NOW LEADERS IN THEIR CHOSEN FIELDS AND BRING TO THEIR POSITIONS THE KNOWLEDGE, RIGOR, THOUGHTFUL PERSPECTIVES, AND VALUES OF EQUITY AND INCLUSION THAT WE EMPHASIZE AT MIT BIOLOGY. WE ANTICIPATE EXCITING FUTURES FOR OUR ALUMNI AS THEY HELP TRANSFORM THE US BIOMEDICAL LANDSCAPE.

POST-TRAUMATIC STRESS INNOVATIONS: U.S. MILITARY ENTERPRISE ANALYSIS

NOAA PROVIDES FUNDING TO SEA GRANT PARTNER INSTITUTIONS TO INCREASE THE UNDERSTANDING, ASSESSMENT, DEVELOPMENT, MANAGEMENT, UTILIZATION, AND CONSERVATION OF THE NATIONS OCEAN, COASTAL, AND GREAT LAKES RESOURCES. THIS FUNDING TYPICALLY OCCURS IN FOUR-YEAR CYCLES, DEFINED HERE AS THE 2024-2027 TIME PERIOD. THE OMNIBUS PROPOSAL SERVES AS THE IMPLEMENTATION GUIDE FOR CARRYING OUT WORK DETAILED IN A PROGRAMS STRATEGIC PLAN FOR THE SAME TIME PERIOD (HTTPS://SEAGRANT.MIT.EDU/WPCONTENT/ UPLOADS/2023/05/MITSEAGRANT_STRATEGICPLAN_2024_2027_508.PDF). ACTIVITIES TO BE PERFORMED: THE MITSG COLLEGE PROGRAM IS COMMITTED TO PROVIDING SCIENTIFIC AND TECHNICAL LEADERSHIP, BRINGING THE EXPERTISE AND RESOURCES OF THE MIT COMMUNITY TO ADDRESS HIGH-PRIORITY ISSUES FOR THE COMMONWEALTH OF MASSACHUSETTS. MITSG WILL CONTINUE TO SUPPORT RESEARCH, DEVELOP INNOVATIVE TECHNOLOGY, AND PROVIDE EDUCATION, OUTREACH, AND EXTENSION SERVICES TO ADDRESS COASTAL AND OCEAN ISSUES OF GREATEST CONCERN TO OUR CONSTITUENT GROUPS IN MASSACHUSETTS, THE REGION, AND BEYOND. FOUR FOCUS AREAS ADDRESS THE CORE OF THE NATIONAL SEA GRANT COLLEGE PROGRAM MISSION AND VISION, AND PROVIDE A FRAMEWORK FOR OUR WORK IN LINE WITH THE MITSG 2024-2027 STRATEGIC PLAN: ENVIRONMENTAL LITERACY AND WORKFORCE DEVELOPMENT; HEALTHY COASTAL ECOSYSTEMS; SUSTAINABLE FISHERIES AND AQUACULTURE; AND RESILIENT COMMUNITIES AND ECONOMIES, ALONG WITH CROSS-CUTTING PRINCIPLES FOCUSING ON DIVERSITY, EQUITY, AND INCLUSION. WE ACCOMPLISH OUR OMNIBUS COMMITMENTS THROUGH A COMBINED EFFORT INVOLVING THREE PRIMARY PROGRAM UNITS: (1) PROGRAM MANAGEMENT: RESPONSIBLE FOR OVERSEEING PROGRAM OPERATIONS AND MANAGEMENT OF THE VARIOUS MITSG FUNDING COMPETITIONS AND FELLOWSHIP PROGRAMS; (2) THE ADVISORY SERVICES GROUP: RESPONSIBLE FOR PROVIDING CONSTITUENT DRIVEN RESEARCH, EDUCATION, OUTREACH, AND EXTENSION PROGRAMS THAT ADDRESS CONSTITUENT NEEDS AND PRIORITIES RELATIVE TO OCEAN AND COASTAL ENVIRONMENTS THROUGH DIRECT COLLABORATIONS AND THE TRANSFER OF INFORMATION AND TECHNOLOGY RESULTING FROM MITSG ASG, FUNDED RESEARCH, AND EDUCATION PROGRAMS; AND (3) EDUCATION: TO INCREASE STEM OCEAN-LITERACY AMONG THE CITIZENS OF MASSACHUSETTS, AND INSPIRING AND TRAINING THE NEXT GENERATION OF MARINE SCIENTISTS AND ENGINEERS WHILE SERVING MASSACHUSETTS COASTAL COMMUNITIES, INDUSTRY, AND RESOURCE MANAGEMENT NEEDS. THIS OMNIBUS PROPOSAL DESCRIBES MITSGS ACTIVITIES FOR THE NEXT FOUR YEARS, WHICH INCLUDE THE FOLLOWING PRIORITY AREAS: FISHERIES AND SEAFOOD TECHNOLOGY, OCEAN ACIDIFICATION, COASTAL RESILIENCE AND CLIMATE IMPACTS, MARINE DEBRIS, OCEAN ENGINEERING EDUCATION, OCEAN RENEWABLE ENERGY, MARINE AQUACULTURE, SUPPORT OF WORKFORCE DEVELOPMENT RELATIVE TO THE SEA GRANT FOCUS AREAS, AND CONSTITUENT EXTENSION SERVICES. THE CONSTITUENT EXTENSION SERVICES ALSO PROVIDE VALUABLE INPUT IN SUPPORT OF THESE PRIORITY AREAS. EXPECTED OUTCOMES: MITSG WILL PROVIDE INFORMATION, TECHNOLOGY, EDUCATION, TRAINING, AND WORKFORCE DEVELOPMENT SERVICES THAT PROVIDE SOLUTIONS FOR CONSTITUENT PRIORITY NEEDS. INTENDED BENEFICIARIES: MITSGS FIRST PRIORITY IS TO SERVE THE PEOPLE, COMMUNITIES, ORGANIZATIONS, AND INDUSTRY OF MASSACHUSETTS. MITSG EXTENDS AND WORKS TO EXTEND THE BENEFITS OF ITS WORK TO CONSTITUENTS BEYOND MASSACHUSETTS. SUBRECIPIENT ACTIVITIES: SUBRECIPIENTS INCLUDE THOSE RECEIVING FUNDING THROUGH THE MITSG BIENNIAL AND STREAM GRANT FUNDING COMPETITIONS, AND THE MITSG FELLOWSHIP OPPORTUNITIES IDENTIFIED IN THE FOLLOWING SECTIONS OF THIS OMNIBUS PROPOSAL. ADDITIONAL SUBRECIPIENTS AND THEIR ACTIVITIES WILL BE IDENTIFIED AS THEY EMERGE THROUGHOUT THE OMNIBUS PERIOD. THE ESTIMATED NUMBER OF PEOPLE TO BE SERVED AS A RESULT OF THE AWARD OF THIS GRANT WILL BE DETERMINED OVER THE FOUR-YEAR OMNIBUS PERIOD.

RESEARCH IN THE AREA OF LEAN AEROSPACE INITIATIVE (LAI) PHASE V IN ACCORDANCE WITH ATTACHMENT 1, STATEMENT OF WORK, DATED 13 MAY 2005.

EPIGENOMIC, TRANSCRIPTIONAL AND CELLULAR DISSECTION OF ALZHEIMER'S VARIANTS

THE RECIPIENT WILL DESIGN AND FIELD VALIDATE ULTRA-LOW PRESSURE DRIP IRRIGATION SYSTEMS FOR THE MENA REGION THAT WILL CUT PUMPING ENERGY BY 50% (FOR

MAPPING THE VULNERABLE LOCUS COERULEUS PATHWAYS IN AGING AND AD - PROJECT SUMMARY ALZHEIMER’S DISEASE IS A DEVASTATING DEMENTIA WITH NO KNOWN CURE. WHILE RESEARCH HAS ADVANCED OUR KNOWLEDGE OF THE GENETICS AND MOLECULAR BIOLOGY OF AD, IT IS NOT YET KNOWN WHY SOME AREAS OF THE BRAIN ARE AFFECTED, WHILE OTHERS ARE SPARED. ADDITIONALLY, THE SENSITIVITY OF CIRCUITS AND SYNAPTIC CONNECTIONS IN DISEASE PROGRESSION ARE NOT KNOWN. WE WILL EXAMINE THE CONNECTIVITY OF THE LOCUS COERULEUS (LC), WHICH PROJECTS TO MOST AREAS OF THE BRAIN, AND IS ONE OF THE REGIONS TO SHOW PATHOLOGY EARLIEST IN AD. WE WILL CHARACTERIZE THE POPULATIONS OF THESE NEURONS BASED ON THEIR CONNECTIVITY AND SENSITIVITY TO DEGENERATION WITH AGING AND IN AD MODEL MICE, BOTH FROM A GLOBAL CONNECTOME LEVEL AND WITH SINGLE-CELL APPROACHES FOR MOLECULAR SIGNATURES. ADDITIONALLY, WE WITH LOOK IN MORE DETAIL AT THE ENTORHINAL CORTEX, ONE OF THE RECIPIENTS OF LC CONNECTIONS WITH PREFERENTIAL CELL LOSS, AND CHARACTERIZE THE SPECIFIC POPULATIONS AND INPUT/OUTPUT RELATIONSHIPS IN RESPONSE TO AGING AND LC PATHOLOGY.

BIOPROCESS AND MICROBE ENGINEERING FOR TOTAL CARBON UTILIZATION IN BIOFUEL PRODUCTION

UNIVERSITY TRANSPORTATION CENTER

COMPUTATIONAL AND EXPERIMENTAL ANALYSIS OF VERTEBRATE RNA SPLICING

A UNIVERSAL PIPELINE FOR FUNCTIONAL CHARACTERIZATION OF THE HUMAN MICROBIOTA AT A MASSIVE SCALE

(MURI-FY22) RULES OF COMPOSITION IN SYNTHETIC BIOLOGY ACROSS SCALES OF COMPLEXITY: THEORY AND TOOLS

MACHINE LEARNING FOR SUBMESOSCALE CHARACTERIZATION, OCEAN PREDICTION, AND EXPLORATION (ML-SCOPE)

NONPARAMETRIC BAYESIAN MODELS TO REPRESENT KNOWLEDGE AND UNCERTAINTY FOR DECENTRALIZED PLANNING

MURI - EMPTY STATE ELECTRONICS ** FAADC MIGRATION NOTE - ACTION TYPE:"1" TO "A", RECORD TYPE:"2", BUSINESS FUNDS INDICATOR:"NON", INDIVIDUAL RECIPIENT INDICATOR:"NO", RESEARCH AND DEVELOPMENT FUNDS INDICATOR:"YES", COMPETED OPPORTUNITY:"1" TO "C", NUMBER OF PROPOSALS OR APPLICATIONS:"1", AWARDING SUB-TIER AGENCY CODE "5700" DERIVED FROM AWARDING OFFICE CODE "FA9550", FUNDING SUB-TIER AGENCY CODE "5700" DERIVED FROM FUNDING OFFICE CODE "F4FGA0", PPOP COUNTRY CODE:"USA", SMALL BUSINESS INDICATOR:"O", SAM EXCEPTION:"X" **

TAS::57 3600::TAS "(MURI 15)- FOLDABLE AND ADAPTIVE TWO-DIMENSIONAL ELECTRONICS", DATED, 23 FEB 2015

PROVABLY-STABLE VISION-BASED CONTROL OF HIGH-SPEED FLIGHT THROUGH FOREST AND URBAN ENVIRONMENTS

FPDS BASE DESCRIPTION, MULTIPLE YEAR AWARD&INCREMENTAL FUNDING FOR YEARS 1 OF 5. THIS PROPOSAL IS ENTITLED, "FOUNDATIONS OF COMPLEX LIFE: EVOLUTION,

FIRE COLLABORATIVE: RAPID HIGH-FIDELITY BULK IRRADIATED MATERIALS DATA GENERATION TO ACCELERATE SOLUTIONS FOR COMMERCIAL FUSION ENERGY SYSTEMS

TAS::57 3600::TAS "(MURI 14)-A UNIFIED MATHEMATICAL AND ALGORITHMIC FRAMEWORK FOR MANAGING MULTIPLE INFORMATION SOURCES OF MULTI-PHYSICS SYSTEMS"

(MURI FY06) ELECTRICALLY-PUMPED, SILICON-BASED LASERS FOR CHIP-SCALE NANOPHOTONICS SYSTEMS

NOVEL DIAGNOSTICS WITH OPTICAL COHERENCE TOMOGRAPHY

GENETIC ANALYSIS OF NEMATODE EGG LAYING

SMART ADAPTIVE RELIABLE TEAMS FOR PERSUSTENT SURVEILLANCE (SMARTS)

ENSEMBLE ACTIVITY IN RAT STRIATUM DURING HABIT LEARNING

TUNABLE 330 GHZ GYROTRON FOR DNP/NMR

NEW COOPERATIVE AGREEMENT TITLED: CHARMME: CENTER FOR HARNESSING MICROBIOTA FROM MILITARY ENVIRONMENTS

ADVANCED GLOBAL ATMOSPHERIC GASES EXPERIMENT (AGAGE) COLLABORATIVE PROJECT: MIT COMPONENT

LLAMAS: A FACILITY INTEGRAL FIELD SPECTROGRAPH FOR THE MAGELLAN TELESCOPES

TAS::89 0336::TAS RECOVERY "RECOVERY" SCIENTISTS AT THE MASSACHUSETTS INSTITUTE OF TECHNOLOGY (CAMBRIDGE,MA) WILL DEVELOP A PARADIGM SHIFTING NEW "A

UNIVERSITY TRANSPORTATION CENTER

ULTRAFAST ELECTRONIC AND STRUCTURAL DYNAMICS IN COMPLEX MATERIALS

TAS::89 0336::TAS RECOVERY RESEARCHERS AT THE MASSACHUSETTS INSTITUTE OF TECHNOLOGY, IN COLLABORATION WITH RUTGERS UNIVERSITY AND 24M TECHNOLOGIES

STUDIES OF CELL POLARITY, CHEMOTROPISM, AND CELL-CYCLE CONTROL

CHEMISTRY AND BIOLOGY OF PLATINUM ANTICANCER DRUGS

MDSPLUS DEVELOPMENT AND SUPPORT

CAP3: A COMPUTER AIDED PERFORMANCE PROGRAMMING PLATFORM

HIGH FIELD DNP AND EPR IN BIOLOGICAL SYSTEMS

PROVABLY SAFE ANDROID APPS

OPTIMIZING OIL PRODUCTION IN OLEAGINOUS YEAST BY CELL-WIDE MEASUREMENTS ANS GENOME-BASED MODELS

NOVEL PLATFORMS FOR SYSTEMATIC OPTICAL CONTROL OF COMPLEX NEURAL CIRCUITS IN VIVO

A MOLECULAR AND CELLULAR ATLAS OF THE MARMOSET BRAIN

COLLABORATIVE RESEARCH: AN EXPEDITION IN COMPUTING FOR COMPILING PRINTABLE PROGRAMMABLE MACHINES

REGULATION OF MRNA PROCESSING

LEVITATED DIPOLE EXPERIMENT

THE PURPOSE OF THIS AGREEMENT IS TO FUND RESEARCH SUPPORTING DSO WITH THE ACCELERATED MOLECULAR DISCOVERY PROGRAM.

INTEGRATED FRAMEWORK FOR CLIMATE CHANGE ASSESSMENT

ELUCIDATING THE MOLECULAR MECHANISMS OF NEUROPSYCHIATRIC SYMPTOMS IN ALZHEIMER'S DISEASE

THE EFFECTS OF ALZHEIMER'S DISEASE RISK GENES ON METABOLISM AND SIGNALING ACROSS CELL TYPES - SUMMARY ALZHEIMER'S DISEASE (AD) IS PERVASIVE AND DEBILITATING, WITH NO TRULY EFFECTIVE TREATMENTS. GENOME WIDE ASSOCIATION STUDIES HAVE FOUND RISK VARIANTS FOR SPORADIC, LATE-ONSET AD, BUT THE MECHANISMS DRIVING THIS RISK ARE STILL UNKNOWN. TWO OF THE SAD VARIANTS WITH THE HIGHEST ASSOCIATION WITH DEVELOPMENT OF AD ARE IN APOLIPOPROTEIN E (APOE) AND ATP-BINDING CASSETTE TRANSPORTER A7 (ABCA7), BOTH OF WHICH ARE INVOLVED IN LIPID METABOLISM. OUR PRIOR WORK DEMONSTRATES THAT THE E4 ALLELE OF APOE (APOE4) HAS CELL TYPE SPECIFIC EFFECTS, INCLUDING ALTERATIONS IN LIPID METABOLISM, BUT IMPORTANT QUESTIONS REMAIN ABOUT THE DOWNSTREAM PATHWAYS AFFECTED BY THIS ALLELE. CRITICALLY, WE DO NOT KNOW HOW APOE4-INDUCED CHANGES INTERACT WITH AGING-RELATED STRESS, LEADING TO LATE-ONSET DISEASE. EVEN LESS IS KNOWN ABOUT HOW ABCA7 ALLELES LEAD TO INCREASED RISK OF AD. WE PROPOSE TO USE A SYSTEMS BIOLOGY APPROACH TO DISCOVER THESE AD-RISK PATHWAYS, RESPONDING TO NOT-AG-18-052 FROM THE NIH, WHICH DESIGNATES “SYSTEMS BIOLOGY OF BRAIN NEURAL CELLS DERIVED FROM HUMAN AD INDUCED PLURIPOTENT STEM CELLS” AS A HIGH-PRIORITY RESEARCH TOPIC. OUR APPROACH USES MULTI-OMIC ANALYSIS OF INDUCED PLURIPOTENT STEM CELL (IPSC) LINES THAT ARE ISOGENIC FOR TWO RISK VARIANTS, APOE4 OR ABCA7 PREMATURE TERMINATION (PTC), WHICH CAN THEN BE DIFFERENTIATED INTO DIVERSE CELL TYPES. USING AN UNBIASED APPROACH, WE WILL REVEAL HOW AD-RISK ALLELES ALTER SIGNALING, METABOLISM, AND STATES OF THE CELLS, HOW THEY AFFECT INDIVIDUAL CELLS AS WELL AS CELL-CELL INTERACTIONS IN COMPLEX CULTURES, AND HOW THEY ALTER CELLULAR RESPONSES TO ACUTE STRESS. IN AIM 1 WE WILL DEEPLY CHARACTERIZE THE EFFECTS OF APOE4 AND ABCA7 PTC IN 2D CULTURE MODELS OF NEURONS, ASTROCYTES, MICROGLIA AND PERICYTES, DIFFERENTIATED FROM ISOGENIC IPSC LINES, EXAMINING CHANGES IN METABOLISM AND POST-TRANSLATIONAL MODIFICATIONS (PTMS) OF PROTEINS. WE WILL USE ADVANCED NETWORK OPTIMIZATION METHODS TO INTEGRATE THE DISPARATE DATA AND TO UNCOVER MOLECULAR INTERACTION NETWORKS THAT LINK TOGETHER CHANGES OBSERVED IN THE INDIVIDUAL OMICS. IN AIM 2, WE INVESTIGATE THE PATHWAYS ALTERED BY RISK ALLELES THAT INFLUENCE CELL-CELL INTERACTIONS IN 3D CULTURE MODELS, USING SPATIALLY-RESOLVED PTM- PROTEOMICS AND METABOLOMICS/LIPIDOMICS AND CAUSAL COMPUTATIONAL MODELS. IN AIM 3, WE WILL EXAMINE THE INTERSECTION OF RISK VARIANT WITH ENVIRONMENTAL AND CELLULAR STRESSORS IN THE 3D CULTURE MODELS. EACH AIM INCLUDES RIGOROUS TESTING OF HYPOTHESES IN VITRO AND BY EXAMINATION OF POSTMORTEM SAMPLES.

HIGHER EDUCATION EMERGENCY RELIEF FUNDS III - INSTITUTIONAL PORTION UNDER THE AMERICAN RESCUE PLAN

VASCULAR DRUG DELIVERY

DEVELOPMENT OF PU.1 INHIBITORY MODULATORS AS NOVEL THERAPEUTICS FOR ALZHEIMER'S DISEASE

CATALYTIC ENANTIOSELECTIVE OLEFIN METATHESIS REACTIONS

SYNTHETIC LIGANDS FOR MODULATING B-CELL RESPONSES

THE PURPOSE OF THIS AGREEMENT IS TO FUND RESEARCH SUPPORTING THE DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA) AUTOMATING SCIENTIFIC KNOWLEDGE EXTRACTION AND MODELING (ASKEM) PROGRAM. THIS EFFORT SHALL BE CARRIED OUT GENERALLY AS SET FORTH IN EXHIBIT B, RESEARCH DESCRIPTION DOCUMENT, DATED JULY 27, 2022, AND IN THE RECIPIENTS PROPOSAL TITLED, DATA DRIVEN METHODS OF LATENT MODEL RECOVERY AND MAINTENANCE, DATED MAY 5, 2022, COPIES OF WHICH ARE IN THE POSSESSION OF BOTH PARTIES.

FOUNDATIONS OF DECISION MAKING WITH BEHAVIORAL AND COMPUTATIONAL CONSTRAINTS

AB-INITIO SOLID-STATE QUANTUM MATERIALS: DESIGN, PRODUCTION, AND CHARACTERIZATION AT THE ATOMIC SCALE

NEW START MURI: RETHINKING REINFORCEMENT LEARNING WITH ASTROCYTE-NEURON COMPUTATIONS.

MECHANISMS AND THERAPEUTICS FOR RETT SYNDROME

EXTRACELLULAR MATRIX BIOMARKERS FOR DIAGNOSIS, PROGNOSIS, IMAGING AND TARGETING

CONTROL AND EXTENSION OF ITER AND ADVANCED SCENARIOS TO LONG PULSE IN EAST AND KSTAR

A GENETIC ENGINEERING TOOLBOX FOR MARMOSETS (GETMARM): DEVELOPMENT AND OPTIMIZATION OF GENOME EDITING AND ASSISTED REPRODUCTION TECHNIQUES FOR MARMOSET MODELS - PROJECT SUMMARY WHILE MICE ARE ESSENTIAL MODELS FOR MANY AREAS OF NEUROSCIENCE, THERE ARE ALSO MANY ASPECTS OF HIGHER BRAIN FUNCTION AND DYSFUNCTION THAT CANNOT BE ADEQUATELY MODELED IN RODENTS. THUS, THERE IS A NEED FOR NEW GENETIC MODELS THAT HAVE BRAIN STRUCTURE AND FUNCTION CLOSER TO HUMANS. FOR THESE REASONS, NON-HUMAN PRIMATES (NHP) PROVIDE AN ATTRACTIVE MODEL TO STUDY HIGHER BRAIN FUNCTION AND BRAIN DISORDERS. A PROMISING EMERGING NHP MODEL IS THE COMMON MARMOSET, A SMALL NEW WORLD PRIMATE THAT HAS MANY ADVANTAGES AS A GENETIC MODEL. ALTHOUGH THE ADAPTATION OF BACTERIAL CRISPR/CAS SYSTEMS FOR TARGETED GENOME ENGINEERING AND MODEL CREATION HAS REVOLUTIONIZED MODERN BIOLOGY, EDITING OF THE MARMOSET GENOME IS STILL IN ITS INFANCY. GIVEN THE SIGNIFICANT TIME AND MONEY REQUIRED FOR MARMOSET GENOME EDITING, NEW METHODS TO INCREASE EDITING EFFICIENCY, DECREASE MOSAICISM, AND IDENTIFY CORRECTLY-EDITED EMBRYOS PRIOR TO TRANSFER TO RECIPIENT FEMALES ARE CRITICAL. ADDITIONALLY, NEW METHODS FOR CONTROLLING THE ZYGOSITY OF FOUNDER ANIMALS ARE NECESSARY TO ENABLE ANALYSIS OF HOMOZYGOUS F0 ANIMALS AND TO AVOID HOMOZYGOUS EDITING WHEN TARGETING ESSENTIAL GENES THAT CAUSE EMBRYONIC LETHALITY UPON BIALLELIC DISRUPTION. TO THESE ENDS, WE PROPOSE A RESEARCH PROGRAM THAT WILL SIGNIFICANTLY ENHANCE OUR ABILITY TO INTRODUCE MULTIPLE TYPES OF EDITS INTO THE MARMOSET GENOME, REDUCE MOSAICISM, CONTROL THE ZYGOSITY OF EDITS, AND IDENTIFY SUCCESSFULLY EDITED EMBRYOS THROUGH PRENATAL GENETIC TESTING. WE WILL DISSEMINATE THESE TECHNOLOGIES AND MODELS THROUGH DIRECT RESOURCE SHARING, IN-PERSON TRAININGS, DEPOSITION TO NIH-SUPPORTED MARMOSET COORDINATION CENTER. TOGETHER, THE PROPOSED ADVANCES WILL SIGNIFICANTLY REDUCE THE TIME, EFFORT, COSTS AND ANIMAL NUMBERS NECESSARY TO MARMOSET GENETIC MODELS AND WILL UNLOCK THE TRUE POTENTIAL OF MARMOSETS FOR BASIC AND TRANSLATIONAL NEUROSCIENCE RESEARCH.

NEW COMPETITIVE COOPERATIVE AGREEMENT MASSACHUSETTS INSTITUTE OF TECHNOLOGY UNDER FOA NUMBER DE-FOA-00002504 (REMEDY) AND CONTROL NUMBER 2504-1517. PROJECT TITLE: “VENTILATION AIR METHANE ABATEMENT VIA CATALYTIC OXIDATION (VAMCO) WITH MACHINE-LEARNING ENHANCED SENSING AND FEEDBACK CONTROLS”

THE PURPOSE OF THIS AGREEMENT IS TO FUND RESEARCH SUPPORTING THE DEFENSE ADVANCED RESEARCH PROJECTS AGENCY DARPA BIOLOGICAL TECHNOLOGIES BTO RESOURCE PROGRAM.

QUANTITATIVE SYSTEMS BIOLOGY OF GLIOBLASTOMA CELLS AND THEIR INTERACTIONS WITH THE NEURONAL AND IMMUNOLOGICAL MILIEU - ABSTRACT – OVERALL THE PRIMARY FOCUS OF THE MIT/DFCI CENTER FOR SYSTEMS BIOLOGY OF GLIOBLASTOMA IS TO UNDERSTAND THE INTERSECTIONS BETWEEN NEURONS, IMMUNE CELLS, AND TUMOR CELLS IN THIS DEADLY TUMOR. THE LACK OF RESPONSE TO IMMUNOTHERAPY STRATEGIES DESPITE PROMINENT INFILTRATES OF IMMUNE CELLS IN MANY GBM HIGHLIGHTS THE IMMUNO- SUPPRESSIVE NATURE OF THE GBM MICROENVIRONMENT AND THE IMPORTANCE OF MORE CLEARLY UNDERSTANDING THE DYNAMIC INTERACTIONS AT THE TUMOR/IMMUNE INTERFACE. SIMILARLY, INTERACTIONS BETWEEN TUMOR CELLS AND NEURAL CELLS IN THE TUMOR MICROENVIRONMENT HAVE EMERGED AS DRIVING FORCES IN TUMOR PROGRESSION AND INVASION, WITH ELECTRICAL SIGNALS FROM NEURONS PROVIDING GROWTH AND MIGRATION STIMULI TO TUMOR CELLS, WHILE TUMOR CELLS LEAD TO ABERRANT ELECTRICAL SIGNALING IN LOCAL NEURONS. THE CENTRAL HYPOTHESIS OF THIS PROPOSAL IS THAT DEVELOPING A SYSTEMS-LEVEL UNDERSTANDING OF THE DYNAMIC INTERACTIONS BETWEEN TUMOR CELLS, NEURONS AND IMMUNE CELLS WILL PROVIDE UNPRECEDENTED INSIGHTS INTO GLIOMA TUMOR BIOLOGY AND FOSTER DEVELOPMENT OF NOVEL THERAPEUTIC STRATEGIES TO ABROGATE TUMOR INVASION, ENHANCE THE EFFICACY OF CYTOTOXIC THERAPIES, AND INCREASE CLEARANCE OF TUMOR BURDEN BY THE INNATE AND ADAPTIVE IMMUNE SYSTEM. THE PLANNED ANALYSES WILL ENABLE BUILDING AN INTEGRATED COMPUTATIONAL MODEL OF TUMOR-NEURAL-IMMUNE INTERACTIONS FOR GBM TUMORS. THE MODEL WILL BE BASED ON A FOUNDATION OF IN VITRO, IN VIVO, AND EX VIVO MODEL SYSTEMS, AND THEN VALIDATED IN DOZENS OF HUMAN PATIENTS. IMAGE-REGISTERED BIOPSIES FROM DIFFERENT TUMOR REGIONS WITHIN EACH PATIENT WILL BE ANALYZED TO TEST PREDICTIONS OF THIS MODEL AGAINST THE ‘GROUND TRUTH’ OF HUMAN TUMORS. THE ULTIMATE GOAL OF THE MIT/DFCI CENTER FOR SYSTEMS BIOLOGY OF GLIOBLASTOMA IS TO IMPROVE PATIENT CARE BY USING SYSTEMS BIOLOGY AND COMPUTATIONAL MODELING TO IDENTIFY THERAPEUTIC STRATEGIES TO SPECIFICALLY DISRUPT CRITICAL TUMOR CELL – MICROENVIRONMENT INTERACTIONS.

BEHAVIORAL CONSEQUENCES AND CELLULAR SUBSTRATES OF PLASTICITY IN VISUAL CORTEX

THIS PROPOSAL SEEKS FIVE YEARS OF CONTINUING FUNDING FOR THE MIT COMPONENT OF THE MULTINATIONAL, GLOBAL ATMOSPHERIC MEASUREMENT PROGRAM ENTITLED ADVA

RESEARCH

NSF I-CORPS HUB (TRACK 1): NEW ENGLAND REGION -THE BROADER IMPACT/COMMERCIAL POTENTIAL OF THIS INNOVATION CORPS (I-CORPS) HUB PROJECT IS TO PROVIDE TRAINING TO SCIENTISTS AND ENGINEERS TO SUPPORT TRANSLATION OF CRITICAL EMERGING TECHNOLOGIES. THE HUB IS A CONSORTIUM OF UNIVERSITIES SPANNING THE NEW ENGLAND REGION. MANY OF THESE RESEARCHERS ARE LOCATED IN RURAL AND DISADVANTAGED AREAS LACKING ACCESS TO THE RESOURCES FOUND IN A ROBUST INNOVATION ECOSYSTEM. THE HUB AIMS TO REDUCE THIS DISPARITY BY CONNECTING I-CORPS PARTICIPANTS WITH CURATED RESOURCES AND MENTORING TO ENHANCE PLACE-BASED INNOVATION ACROSS NEW ENGLAND. THE GOAL IS TO HAVE AN IMPACT ON LOCAL ECONOMIES, GENERATING GOOD-PAYING JOBS, REVITALIZING MANUFACTURING, AND ACCELERATING NEW INDUSTRIES. THE HUB WILL STRIVE TO ENSURE THE PARTICIPATION OF ALL AMERICANS, INCLUDING THOSE FROM GROUPS TRADITIONALLY UNDERSERVED IN INNOVATION AND ENTREPRENEURSHIP. IN ADDITION, THE HUB PLANS TO PROACTIVELY RECRUIT PARTICIPANTS FROM INSTITUTIONS THAT ARE NOT HUB PARTNERS. I-CORPS TRAINING WILL FORM THE FOUNDATION TO GROW AN ENTREPRENEURIALLY MINDED PROFESSIONAL SCIENCE, TECHNOLOGY, ENGINEERING AND MATHEMATICS (STEM) WORKFORCE AND DEVELOP NEW PRODUCTS AND SERVICES TO BENEFIT SOCIETY AND INCREASE REGIONAL AND U.S. COMPETITIVENESS. THIS I-CORPS HUB PROJECT IS BASED ON THE DEVELOPMENT OF A REGIONAL NETWORK THAT PROVIDES STEM RESEARCHERS THROUGHOUT NEW ENGLAND WITH INCLUSIVE I-CORPS ENTREPRENEURIAL TRAINING, MENTORING, AND SUPPORT. THE GOAL IS TO PROMOTE AND ACCELERATE THE TRANSLATION OF FUNDAMENTAL RESEARCH TO PRODUCTS AND SERVICES THAT IMPROVE SOCIETAL WELL-BEING AND DRIVE ECONOMIC GROWTH. WHILE PARTICIPANTS FROM ALL STEM DISCIPLINES WILL BE RECRUITED, EMPHASIS WILL BE ON THE TECHNOLOGICAL NATIONAL GOALS IN THE CHIPS AND SCIENCE ACT OF 2022, AS WELL AS THOSE BENEFITTING LOCAL COMMUNITIES, SUCH AS BLUETECH, FORESTRY, SUSTAINABILITY, AND BIOTECH/LIFE SCIENCES. THE HUB WILL DELIVER I-CORPS TRAINING ON A LARGE-SCALE AND HIGH FREQUENCY TO RESEARCHERS THROUGHOUT THE REGION VIA BOTH ONLINE AND IN-PERSON COURSES REACHING HIGHER EDUCATION COLLEGES AND UNIVERSITIES. THIS TRAINING WILL BE ACCOMPLISHED BY CO-TEACHING USING A REGIONAL INSTRUCTOR POOL FROM ALL PARTNER INSTITUTIONS WITH CONTINUAL SKILL DEVELOPMENT. IN ADDITION, THE NUMBER OF RESEARCHERS PARTICIPATING IN I-CORPS IS EXPECTED TO GROW AND BE MORE DIVERSE, GENERATING SIGNIFICANT NEW DEEP TECH VENTURES WHILE INCREASING THE ODDS OF COMMERCIAL SUCCESS AND SOCIETAL IMPACTS. OUTREACH WILL BE A PRIMARY ACTIVITY OF THE HUB TO ENSURE THAT ALL RESEARCHERS IN NEW ENGLAND HAVE THE OPPORTUNITY TO PARTICIPATE IN I-CORPS AND BENEFIT FROM THIS TRAINING. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

CHARACTERIZATION OF THE DROSOPHILA SYNAPTOTAGMIN FAMILY

ENGINEERED ANTIBODY EGFR ANTAGONIST CANCER THERAPEUTICS

EXPERIMENTAL - THEORETICAL STUDIES OF COCHLEAR MECHANISMS

UNDERSTANDING THE ROLE OF METABOLISM IN CANCER

GHOST-GIGAHERTZ HIGH RESOLUTION OPTICAL SAMPLING TECHNOLOGY

HIGH POWER MILLIMETER WAVE/TERAHERTZ SOURCES FOR MAGNETIC RESONANCE

I-CORPS NODE: NEW ENGLAND REGIONAL INNOVATION NODE (NERIN)

"(MURI 05) COMPUTATIONAL MODELS FOR BELIEF REVISION, GROUP DECISIONS, AND CULTURAL SHIFTS" DATED 17 NOV 04 AND REVISED BUDGET 11 MAY 05; THE TERMS AN

INTEGRATING DATA, MODELS, AND REASONING IN CRITICAL CARE

NEUTRINO PHYSICS TASK W

EXPEDITIONS: COLLABORATIVE RESEARCH: UNDERSTANDING THE WORLD THROUGH CODE

NOVEL TERAHERTZ-INDUCED QUANTUM STATES PROBED WITH ULTRAFAST COHERENT X-RAYS

FOUNDATIONS OF DATA SCIENCE INSTITUTE

A NEW DEVICE FOR ELECTRICAL & CHEMICAL MODULATION OF PATHOLOGICAL NEURAL ACTIVITY

GRANT

SPECIFICITY IN CO-AND POST-TRANSLATIONAL MODIFICATION

DETERMINANTS OF ELDERLY HEALTH: THE ROLE OF PLACE-BASED FACTORS - PROJECT SUMMARY/ABSTRACT DETERMINANTS OF ELDERLY HEALTH: THE ROLE OF PLACE-BASED FACTORS THE GOAL OF THE PROPOSED RESEARCH IS TO BETTER UNDERSTAND THE FACTORS AFFECTING THE HEALTH AND HEALTH BEHAVIORS OF THE ELDERLY POPULATION IN THE UNITED STATES BY MOVING BEYOND THE WORK OF THE PRIOR GRANT, WHICH AGGREGATED ANALYSIS OF ELDERLY HEALTHCARE UTILIZATION, TO LOOK DIRECTLY AT HEALTH BEHAVIORS AND HEALTH OUTCOMES. AS RECENT WORK HAS SHOWN, THERE ARE LARGE DISPARITIES IN LIFE EXPECTANCY AMONG THE MEDICARE POPULATION BY RACE, INCOME, AND GEOGRAPHY, DESPITE ACCESS TO THE SAME UNIVERSAL HEALTH INSURANCE PROGRAM. BY EXAMINING TWO POTENTIAL BROAD-BASED FORCES, PERSON-SPECIFIC FACTORS (“HEALTH CAPITAL”), WHICH CAN INCLUDE GENETIC ENDOWMENTS AS WELL AS PRIOR MEDICAL CARE, AND PLACE-BASED FACTORS (“CURRENT PLACE EFFECTS”), WHICH IS THE ENVIRONMENT ASSOCIATED WITH THEIR CURRENT LOCATION, WE HOPE TO GATHER FINDINGS THAT WILL GREATLY ENRICH NOT ONLY OUR UNDERSTANDING OF THE FACTORS THAT AFFECT THE ELDERLY’S HEALTH BEHAVIORS AND HEALTH, BUT ALSO SHED LIGHT ON THE LIKELY EFFICACY OF ALTERNATIVE POLICIES AIMED AT IMPROVING ELDERLY HEALTH BEHAVIORS AND HEALTH. TO ACCOMPLISH THIS GOAL, THE PROPOSAL HAS THREE CENTRAL AIMS. IN AIM 1, WE FOCUS ON A SPECIFIC, HARMFUL HEALTH BEHAVIOR: OPIOID ADDICTION. THE ELDERLY POPULATION USES PRESCRIPTION OPIOIDS AT A HIGHER RATE THAN ANY OTHER AGE GROUP, THEREFORE SUGGESTING THAT THIS CRISIS IS ACUTE AMONG THE ELDERLY AND MAY WORSEN AS THE NEAR- ELDERLY CONTINUE TO AGE. BY ANALYZING PERSON-SPECIFIC FACTORS, SUCH AS MENTAL HEALTH STATUS AND PRIOR SUBSTANCE ABUSE, AS WELL AS PLACE-SPECIFIC FACTORS, INCLUDING AVAILABILITY OF PHYSICIANS WILLING TO PRESCRIBE OPIOIDS FOR WHAT THEY PERCEIVE AS LEGITIMATE REASONS OR THE PRESENCE OF POLICIES SUCH AS PRESCRIPTION MONITORING PROGRAMS INTENDED TO LIMIT ABUSE, WE HOPE TO GAIN A BETTER UNDERSTANDING OF BOTH THE CAUSES OF THE OPIOID CRISIS AND THE LIKELY IMPACTS OF POLICIES DESIGNED TO COMBAT IT. IN THE SECOND PART OF THE PROPOSED RENEWAL, WE WILL EXTEND BEYOND THE EMPIRICAL METHODOLOGY EMPLOYED IN AIM 1 TO FOCUS ON THE ROLE OF PLACE-BASED FACTORS IN TWO SPECIFIC WAYS. IN AIM 2, WE WILL ANALYZE THE IMPACT OF PLACE-BASED FACTORS ON ELDERLY MORTALITY. IN AIM 3, WE WILL ANALYZE THE ROLE OF PLACE-BASED FACTORS IN CONTRIBUTING TO HEALTH DISPARITIES AMONG THE ELDERLY POPULATION. IT IS CRITICAL TO UNDERSTAND THE RELATIVE ROLES OF CURRENT PLACE EFFECTS AND PERSON-SPECIFIC FACTORS IN CONTRIBUTING TO ELDERLY MORTALITY AND ELDERLY MORTALITY DISPARITIES IN ORDER TO MORE FULLY UNDERSTAND THE FACTORS THAT MAY LEAD TO ELDERLY MORTALITY AND THE LIKELY EFFECTS OF POLICIES ON ELDERLY HEALTH. THROUGH THESE AIMS WE HOPE TO GAIN A CLEARER UNDERSTANDING OF HOW PERSON- SPECIFIC AND PLACE-SPECIFIC FACTORS AFFECT THE HEALTH BEHAVIORS AND HEALTH OUTCOMES OF THE ELDERLY POPULATION IN THE UNITED STATES.

MOLECULAR GENETICS OF RHIZOBIUM NODULATION PLASMIDS

SINGLE-CELL EPIGENOMIC AND TRANCRIPTIONAL DISSECTION OF SEX-SPECIFIC DIFFERENCES IN ALZHEIMER?S DISEASE - ABSTRACT ALZHEIMER’S DISEASE (AD) IS A DEVASTATING NEURODEGENERATIVE DISORDER THAT LEADS TO DRAMATIC EFFECTS ON THE AFFECTED INDIVIDUALS AND THEIR FAMILIES. WHILE THE CHARACTERIZATION OF THE GENETIC CONTRIBUTION TO AD AND UNDERLYING MOLECULAR MECHANISMS HAVE ADVANCED THE UNDERSTANDING OF THE DISEASE IN RECENT YEARS, STUDIES SHOW THAT SEX DIFFERENCES ACCOUNT FOR MUCH OF THE OBSERVED DIFFERENCES IN RISK, PROGRESSION, AND SEVERITY ACROSS INDIVIDUALS. HERE, WE DIRECTLY DISSECT THE CONTRIBUTION OF SEX-SPECIFIC VARIATION DOWN TO THE REGION- SPECIFIC AND CELL-TYPE-SPECIFIC MOLECULAR BASIS BY SYSTEMATIC PROFILING, COMPUTATIONAL INTEGRATION, AND EXPERIMENTAL VALIDATION OF THE TRANSCRIPTIONAL, EPIGENOMIC, AND GENETIC SIGNATURES ACROSS INDIVIDUALS, BRAIN REGIONS, AND CELL TYPES. IN AIM 1, WE USE GENETIC, EPIGENOMIC, AND TRANSCRIPTIONAL PROFILES, GENERATING MILLIONS OF SINGLE-CELL (SC) LEVEL MAPS USING SCRNA-SEQ AND SCATAC-SEQ ACROSS HUMAN AND MOUSE SAMPLES OF VARYING AGES AND GENETIC RISK STATUS. IN AIM 2, WE ANALYZE THE RESULTING DATASETS IN THE CONTEXT OF KNOWN AD GENETIC RISK VARIATION AND UNDERLYING MOLECULAR MECHANISMS, ENABLING US TO DISCOVER AND CONVERGE VARIANTS, REGULATORY REGIONS, GENES, PATHWAYS, CELL TYPES, AND BRAIN REGIONS TO FUNCTIONAL, CAUSAL MECHANISMS THAT DRIVE SEX-RELATED DIFFERENCES. IN AIM 3, WE USE OUR WELL-ESTABLISHED MOUSE AND IPSC MODELS TO TEST OUR PREDICTED MECHANISMS WITH BOTH HIGH-THROUGHPUT AND CELL-TYPE SPECIFIC ASSAYS. THE RESULTING DATASETS, COMPUTATIONAL PREDICTIONS, AND EXPERIMENTALLY-SUPPORTED MECHANISMS WILL SHED LIGHT ON THE SEX-RELATED DIFFERENCES OF AD AND WILL HELP DEEPEN OUR UNDERSTANDING THE DISEASE IN GENERAL AS WE DEVELOP MORE PERSONALIZED THERAPEUTIC APPROACHES IN TREATING AD.

HOW DOES THE FUNCTIONAL ORGANIZATION OF THE HUMAN BRAIN ARISE IN DEVELOPMENT

UNIVERSITY TRANSPORTATION CENTER - STRATEGIC MANAGEMENT OF TRANSPORTATION SYSTEMS

GEOSPACE FACILITIES: IMPROVING MILLSTONE GEOSPACE RADAR PERFORMANCE AND LIFETIME

MIT MATERIALS RESEARCH SCIENCE AND ENGINEERING CENTER

CATALYTIC METHODS FOR ORGANIC SYNTHESIS

THE PURPOSE OF THIS AGREEMENT IS TO FUND RESEARCH SUPPORTING THE DEFENSE ADVANCED RESEARCH PROJECTS AGENCY DARPA BIOLOGICAL TECHNOLOGIES BTO ATMOSPHERIC WATER EXTRACTION AWE PROGRAM. THIS EFFORT SHALL BE CARRIED OUT GENERALLY AS SET FORTH IN EXHIBIT B, RESEARCH DESCRIPTION DOCUMENT, DATED JULY 13, 2020, AND IN THE RECIPIENTS PROPOSAL TITLED, HIGH-PERFORMANCE PORTABLE ATMOSPHERIC WATER EXTRACTOR FOR EXTREME CLIMATES.

OPTICAL-TRANSITION CLOCKS WITH MICRO-FABRICATED FREQUENCY COMBS FOR PERFORMANCE BEYOND THE STANDARD QUANTUM LIMIT

TAS::97 0400::TAS A GENERAL-PURPOSE PROBABILISTIC PROGRAMMING PLATFORM WITH EFFECTIVE STOCHASTIC INFERENCE

INTENTIONAL MULTI-MODAL SELF-LEARNING TO PERCEIVE AND UNDERSTAND THE REAL WORLD

INTEGRATED ARTIFICIAL MUSCLE, HIGH-LIFT, BIO-HYDRODYNAMIC MECHANISM FOR BIOROBOTIC AUTONOMOUS UNDERSEA VEHICLES

THE PURPOSE OF THIS AGREEMENT IS TO FUND RESEARCH SUPPORTING THE DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA) GUESSING RANDOM ADDITIVE NOISE DECODING (GRAND) STUDY. THIS EFFORT SHALL BE CARRIED OUT GENERALLY AS SET FORTH IN EXHIBIT B, RESEARCH DESCRIPTION DOCUMENT, DATED MAY 26, 2021, AND IN THE RECIPIENTS PROPOSAL TITLED, GRAND: GUESSING RANDOM ADDITIVE NOISE DECODING, PROVIDED TO CMO FEBRUARY 10, 2021, COPIES OF WHICH ARE IN THE POSSESSION OF BOTH PARTIES.

STUDIES OF FUSION PILOT PLANT PHYSICS IN SPARC EARLY CAMPAIGNS AND Q GREATER THAN 1 PLASMAS

FUSION OF NANOMAGNETIC AND VIRAL TOOLS TO INTERROGATE BRAIN-BODY CIRCUITS - ABSTRACT THE INFORMATION FLOW BETWEEN THE PERIPHERAL ORGANS AND THE BRAIN IS INCREASINGLY RECOGNIZED AS BIDIRECTIONAL, WITH ACTIVITY IN PERIPHERAL CIRCUITS INFLUENCING HIGH-LEVEL BEHAVIORS INCLUDING MOOD, MOTIVATION, AND STRESS. TO ESTABLISH MECHANISTIC LINKS BETWEEN ACTIVITY OF PERIPHERAL NEURONS AND BRAIN CIRCUITS, WE WILL DEVELOP A SPECIES- AGNOSTIC FRAMEWORK FOR TARGETING AND REMOTE MODULATION OF SPECIFIC CELLS WITHIN THE PERIPHERAL ORGANS AND THE BRAIN DURING BEHAVIOR. OUR FRAMEWORK WILL COMBINE THE HOMING, MODULATION, AND CONTRAST PROPERTIES OF SYNTHETIC MAGNETIC NANOMATERIALS WITH THE TARGETING SPECIFICITY OF VIRAL VECTORS. MAGNETIC NANOMATERIALS HAVE RECENTLY EMERGED AS VERSATILE TRANSDUCERS OF REMOTELY APPLIED WEAK MAGNETIC FIELDS INTO THERMAL, CHEMICAL, OR MECHANICAL STIMULI PERCEIVED BY ION CHANNELS. WE WILL DRAMATICALLY EXPAND THE PALETTE OF MAGNETIC NANOTRANSDUCERS TO ENABLE RECEPTOR-SPECIFIC REMOTE MAGNETIC MODULATION OF NEURONS (OR OTHER ELECTROGENIC CELLS) ANYWHERE IN THE BODY DURING FREE BEHAVIOR. MOREOVER, WE WILL LEVERAGE RECENT ADVANCES IN ADENO-ASSOCIATED VIRAL VECTORS FOR TARGETING SPECIFIC CELLS AND TISSUES BY CREATING AN ARRAY OF FUSIONS OF NANOTRANSDUCERS AND VIRAL CAPSIDS. THIS WILL ALLOW FOR MAGNETIC GUIDANCE AND LOCALIZATION OF THE HYBRID MAGNETIC- VIRAL FUSIONS TO THE LOCATIONS OF INTEREST FOLLOWING SYSTEMIC DELIVERY REGARDLESS OF THE MODEL ORGANISM. WE WILL APPLY OUR FRAMEWORK TO ELUCIDATE CIRCUITS CONNECTING THE ENTERIC (GUT) NERVOUS SYSTEM TO THE MIDBRAIN STRUCTURES. RECENT WORK HAS DRAWN LINKS BETWEEN GASTROINTESTINAL DYSFUNCTION AND SOCIAL AND MOOD DISORDERS AS WELL AS DEMONSTRATED VAGAL TRANSMISSION OF THE ENTERIC SIGNALS TO THE BRAIN. BY APPLYING RECEPTOR-SPECIFIC MODULATION TO THE ENTERIC NEURONS WE INTEND TO TEST THE HYPOTHESIS THAT THEIR ACTIVITY INFLUENCES MIDBRAIN PATHWAYS GOVERNING REWARD AND MOTIVATION, AND POSSIBLY MOTOR BEHAVIORS. IN ADDITION TO EMPOWERING STUDIES OF GUT-BRAIN CIRCUITS, OUR SPECIES-AGNOSTIC FRAMEWORK CAN BE EXTENDED TO INVESTIGATE CONNECTIONS BETWEEN ANY PERIPHERAL ORGAN AND THE BRAIN THUS OPENING OPPORTUNITIES TO DEVELOP PERIPHERAL ORGAN INTERVENTIONS FOR NEUROLOGICAL AND MENTAL CONDITIONS.