Leo Inc

COLLABORATIVE RESEARCH IN MILITARY CONSEQUENCE MANAGEMENT

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SPECIAL COURT FOR SIERRA LEONE - AMENDMENT 001. THIS IS A COST AMENDMENT TO ADD FUNDS.

CARES ACT - HIGHER EDUCATION EMERGENCY RELIEF FUND

TO SUPPORT THE "INL/COLOMBIA NATIONAL POLICE SCHOLARSHIP PROGRAM"

CARES ACT - HIGHER EDUCATION EMERGENCY RELIEF FUND

COVID-19 DPA3 MEGA-CONSTELLATION CONTROL AND CERTIFICATION OF COMMERCIAL SPACE DATA

COLLABORATIVE RESEARCH IN HUMAN SCIENCES AND RELATED GENERAL STUDIES AND ANALYSES

THE PROPOSED EFFORT IS SEGREGATED INTO TWO MAIN CATEGORIES: "MURI" AND "CUBESAT." THE MURI EFFORT INCLUDES FLIGHT TEST RADIATION TESTING AND THE PZT LAUNCH LOCK.

DS-19 BUSINESS INCUBATOR

SCALABLE QUANTUM INFORMATION PROCESSING (SQIP) WITH TRAPPED IONS

DEFENSE PRODUCTION ACT, TITLE III, AN/SSQ-101B SONOBUOYS PRODUCTION CAPABILITY PROJECT

SUPER UNCOOLED MULTI-BAND RADIOMETER SENSOR (SUMRS)

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TO IMPROVE POLICE COMMUNITY RELATIONS AND ASSIST IN THE CONTROL OF ILLICIT CROPS/

COVID-19 DPA3 "LASER DIODE PROCESS OPTIMIZATION PROGRAM"

IMPROVING PUBLIC HEALTH GLOBALLY: STRENGTHENING PUBLIC HEALTH IMPACT , SYSTEMS, CAPACITY, AND SECURITY IN SIERRA LEONE

CERTIFIED TOPOLOGICAL QUANTUM COMPUTATION

IMPROVE EXISTING AIRPORT

INNOVATIVE 3D PRINTED INTRAVAGINAL RING ANELLEO-PRO, THE FIRST SINGLE ADMINISTRATION OF PROGESTERONE FOR INFERTILITY - PROJECT SUMMARY INFERTILITY IS A GLOBAL HEALTH PROBLEM. IN THE US ALONE, ~1.7 MILLION WOMEN ARE TREATED FOR INFERTILITY EVERY YEAR. TO IMPROVE INFERTILITY TREATMENT, THERE IS A STRONG NEED TO PROMOTE PATIENT-FRIENDLY METHODS FOR PROGESTERONE SUPPLEMENTATION IN ASSISTED REPRODUCTIVE TECHNOLOGY (ART). INTRAVAGINAL RINGS, WHICH ARE WELL TOLERATED BY WOMEN, ARE EFFICACIOUS FOR CONTRACEPTION AND HORMONE REPLACEMENT THERAPY, AND HAVE HIGH PATIENT COMPLIANCE, ARE NOW IN DEVELOPMENT FOR ART. HOWEVER, DEVELOPING EFFECTIVE IVRS TO DELIVER PROGESTERONE BEYOND 7 DAYS IS CHALLENGING DUE TO LIMITATIONS OF CURRENT ENGINEERING PROCESSES, AND DIFFICULTY IN CONTROLLING RELEASE RATES, THUS MANDATING DRUG-SPECIFIC CUSTOMIZED IVR DESIGNS. OUR GOAL IS TO ADDRESS THESE LIMITATIONS BY REVOLUTIONIZING THE ENGINEERING AND MANUFACTURING PROCESSES FOR INTRAVAGINAL RINGS, USING A STATE-OF-THE-ART 3D PRINTING PROCESS KNOWN AS CONTINUOUS LIQUID INTERFACE PRODUCTION (CLIP™). USING THE AUTOMATED CLIP PROCESS, WE CAN ENGINEER AND MANUFACTURE IVRS WITH SURFACE GEOMETRIES NOT ACHIEVABLE WITH TRADITIONAL INJECTION MOLDING OR EXTRUSION, WHICH HELP CONTROL DRUG RELEASE. CLIP ENABLES US TO PRECISELY FINE-TUNE DIFFUSION AND RELEASE OF DRUGS, TO ACHIEVE NEAR COMPLETE RELEASE, AND INDEPENDENTLY CONTROL IVR MECHANICAL PROPERTIES. IMPORTANTLY, USING CLIP, WE CAN MANUFACTURE IVRS THAT PROVIDE SUSTAINED RELEASE OF PROGESTERONE TO COVER THE ENTIRE ART TREATMENT PERIOD IN A RAPID AND COST-EFFECTIVE SINGLE-STEP PROCESS. IN THIS PHASE II SBIR PROJECT, WE PROPOSE TO BUILD ON OUR EXISTING DATA FROM PHASE I TO OPTIMIZE A PROGESTERONE IVR NAMED ANELLEO-PRO, TEST ITS EFFICACY IN A RELEVANT MACAQUE MODEL, AND CONDUCT IND-ENABLING STUDIES TO SUPPORT AN IND-APPLICATION. WE WILL IMPLEMENT COMPREHENSIVE RATIONAL IVR DESIGN, USING THE HIGHLY RELEVANT PRECLINICAL SHEEP AND MACAQUE MODELS TO CHARACTERIZE THE SAFETY, PHARMACOKINETIC PROFILES, AND EFFICACY OF OPTIMIZED ANELLEO-PRO. THIS MULTIDISCIPLINARY, CUTTING-EDGE APPROACH WILL DEVELOP A UNIQUE AND HIGHLY INNOVATIVE 3D PRINTED CLIP IVR – ANELLEO-PRO, DELIVERING PROGESTERONE IN A LONG-ACTING, SINGLE ADMINISTRATION TREATMENT OF INFERTILITY.

SCALABLE MEMORY-ENHANCED ION-TRAP QUANTUM NETWORK (SCINET)

NA HUA KANU

ASSESSMENT OF YOUTH INTERVENTIONS IN ASEMBO AND GEM NYANZA, PROVINCE, KENYA

DESCRIPTION:THIS AGREEMENT PROVIDES FUNDING TO LEONI TOWNSHIP TO IMPLEMENT ITS WASTEWATER TREATMENT PLANT IMPROVEMENT PROJECT AS DIRECTED IN THE 2022 CONSOLIDATED APPROPRIATIONS ACT OR AS IDENTIFIED IN AN APPROVED TECHNICAL CORRECTION IF ONE HAS BEEN APPROVED FOR THIS PROJECT. ACTIVITIES:THE ACTIVITIES TO BE PERFORMED INCLUDE THE EXECUTION AND IMPLEMENTATION OF A WASTEWATER INFRASTRUCTURE CONSTRUCTION PROJECT. WORKPLAN ACTIVITIES CONSIST OF: IMPROVEMENTS TO INFLUENT HANDLING, BIOSOLIDS STORAGE BARN EXPANSION, UPGRADES TO THE SEPTAGE RECEIVING FACILITY, AND MISCELLANEOUS IMPROVEMENTS. SUBRECIPIENT:NO SUBAWARDS ARE INCLUDED IN THIS ASSISTANCE AGREEMENT.OUTCOMES:THE ANTICIPATED DELIVERABLES INCLUDE NEW FLOW METERS ON THE FIVE MAIN FORCEMAINS THAT DELIVER FLOW TO THE WWTP, EXPANSION OF THE EXISTING BIOSOLIDS STORAGE BARN, UPGRADING THE SCREENING ROOM'S HVAC SYSTEMS, RECONSTRUCTION OF ONSITE ASPHALT ACCESS DRIVES AND RELATED DRAINAGE SYSTEMS. THE EXPECTED OUTCOMES INCLUDE REDUCED INFLOW AND INFILTRATION AND RELIABLE WASTEWATER SERVICE. THE INTENDED BENEFICIARIES INCLUDE RESIDENTS OF JACKSON COUNTY, LENAWEE COUNTY, AND WASHTENAW COUNTY.

DESCRIPTION:THE AGREEMENT PROVIDES FUNDING TO LEONARDO ACADEMY. SPECIFICALLY, THE RECIPIENT WILL REPLACE OLDER DIESEL TIER 3 STRADDLE CARRIERS WITH NEWER, CLEANER HYBRID-ELECTRIC STRADDLE CARRIERS TO REDUCE EMISSIONS OF DIESEL PARTICULATE MATTER, NOX AND EXPOSURE TO DIESEL AIR TOXICS IN ESSEX COUNTY, NEW JERSEY. REPLACING OLDER DIESEL CARGO HANDLING EQUIPMENT WITH NEWER HYBRID-ELECTRIC STRADDLE CARRIERS WILL REDUCE EMISSIONS OF DIESEL PARTICULATE MATTER AND OTHER POLLUTANTS SUCH AS NITROGEN OXIDES.ACTIVITIES:LEONARDO ACADEMY WILL ENSURE PROJECT GOALS OF THE SCRAPPING DIESEL STRADDLE CARRIERS AND PURCHASING HYBRID-ELECTRIC STRADDLE CARRIERS ALONG WITH PROJECT PARTNERS. THE ACTIVITIES INCLUDE PURCHASING HYBRID-ELECTRIC CARRIERS THROUGH A COMPETITIVE PROCUREMENT PROCESS AND COORDINATING THE DESTRUCTION AND RECYCLING OF THE OLD ENGINES AND STRADDLE CARRIERS. SUBRECIPIENT:A SUBAWARD WILL BE GIVEN TO THE SUBRECIPIENT, PORT NEWARK CONTAINER TERMINAL. THE ACTIVITIES TO BE IMPLEMENTED THROUGH THE SUBAWARD ENTAIL REPLACING DIESEL-POWERED CARGO HANDLING EQUIPMENT CALLED STRADDLE CARRIERS WITH HYBRID ELECTRIC STRADDLE CARRIERS. THE GRANT WILL BE MANAGED BY LEONARDO ACADEMY WHO WILL OVERSEE THE IMPLEMENTATION OF THE AWARD. THE CARGO HANDLING EQUIPMENT OWNERS, AS SUBRECIPIENTS, WILL PROCURE REPLACEMENT STRADDLE CARRIERS IN COMPLIANCE WITH PROCUREMENT RULES, PERMANENTLY DISABLE AND DECOMMISSION OLD NON-ROAD DIESEL STRADDLE CARRIERS AND SUBMIT ALL REQUIRED DOCUMENTATION TO LEONARDO ACADEMY, WHO WILL THEN SUBMIT THEM TO EPA. PORT NEWARK CONTAINER TERMINALS AND LEONARDO ACADEMY WILL MAKE QUARTERLY AND ANNUAL REPORTS TO EPA TO SUMMARIZE THE STATUS OF THE SCRAPPAGE AND PURCHASE OF THE CARGO HANDLING EQUIPMENT.OUTCOMES:THE ANTICIPATED DELIVERABLES INCLUDE THE REPLACEMENT OF OLD DIESEL CARGO HANDLING EQUIPMENT CALLED STRADDLE CARRIERS WITH NEWER, CLEANER HYBRID-ELECTRIC STRADDLE CARRIERS. THE EXPECTED OUTCOMES INCLUDE REDUCTIONS IN PARTICULATE MATTER AND NITROGEN OXIDES, REDUCING THESE HARMFUL EMISSIONS THROUGHOUT OUR NATION WILL PREVENT PREMATURE DEATHS, ASTHMA RELATED ER VISITS, AIR RELATED HOSPITALIZATIONS, HEART ATTACKS, AND COUNTLESS MISSED WORKDAYS EACH YEAR. THE INTENDED BENEFICIARIES INCLUDE NEAR-PORT COMMUNITIES, PORT DOCKWORKERS AND PORT NEWARK CONTAINER TERMINAL.

HIGHER EDUCATION EMERGENCY RELIEF FUND: INSTITUTIONAL USE

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TEENAGE PREGNANCY PREVENTION (TIER 1)

IMPROVE ACCESS TO BEHAVIORAL AND PHYSICAL HEALTH SERVICES BY TRANSFORMING VALEO BEHAVIORAL HEALTH CARE FROM A COMMUNITY MENTAL HEALTH CENTER TO A CERTIFIED COMMUNITY BEHAVIORAL HEALTH CLINIC - VALEO BEHAVIORAL HEALTH CARE, INC. WILL IMPROVE ACCESS TO BEHAVIORAL AND PHYSICAL HEALTH SERVICES BY TRANSFORMING VALEO FROM A COMMUNITY MENTAL HEALTH CENTER (CMHC) TO A CERTIFIED COMMUNITY BEHAVIORAL HEALTH CLINIC (CCBHC). VALEO'S PRIMARY POPULATION OF FOCUS ARE ADULTS (18+) IN SHAWNEE COUNTY, KANSAS WITH MENTAL HEALTH CONDITIONS, SUBSTANCE USE DISORDERS OR CO-OCCURRING DISORDERS WHO LACK HEALTH INSURANCE COVERAGE, ARE UNDERINSURED, OR CANNOT AFFORD SUBSIDIZED HEALTH INSURANCE, WITH AN EMPHASIS ON INDIVIDUALS WHO ARE 65 AND OLDER, INDIVIDUALS EXPERIENCING HOMELESSNESS, AND THOSE WHO HAVE SERIOUS MENTAL ILLNESS. TOPEKA, THE KANSAS CAPITAL, LIES WITHIN THE BOUNDARIES OF SHAWNEE COUNTY WHICH ENCOMPASSES THE CCBHC SERVICE AREA. SHAWNEE COUNTY IS HOME TO AN ESTIMATED 176,875 RESIDENTS. THERE ARE NO CCBHCS IN THE SERVICE AREA, THOUGH THERE IS ANOTHER CMHC THAT PROVIDES BEHAVIORAL HEALTH SERVICES FOR CHILDREN UP TO 18 YEARS OLD. FOR INDIVIDUALS WITHOUT INSURANCE, VALEO IS ONE OF FOUR PROVIDERS IN THE AREA FOR ADULTS (18+). VALEO IS THE ONLY ADULT PROVIDER WHO WILL PROVIDE SERVICES REGARDLESS OF AN INDIVIDUAL'S ABILITY TO PAY. APPROXIMATELY 17.4% OF THE COUNTY'S POPULATION IS WITHOUT INSURANCE DUE, IN PART, TO KANSAS NOT EXPANDING MEDICAID. THROUGH A SURVEY CONDUCTED BY THE SHAWNEE COUNTY HEALTH DEPARTMENT, RESPONDENTS IDENTIFIED MENTAL HEALTH ISSUES, ALCOHOL/ILLEGAL DRUG ABUSE, PRESCRIPTION DRUG ABUSE/DEPENDENCE, AND OBESITY AS SIGNIFICANT COMMUNITY ISSUES. VALEO WILL SERVE AN ADDITIONAL 2,000 INDIVIDUALS OVER THE COURSE OF THE FOUR-YEAR GRANT PERIOD (500 IN YEAR ONE, 500 IN YEAR TWO, 500 IN YEAR THREE, AND 500 IN YEAR FOUR). THE PROJECT'S FIRST GOAL IS TO INCREASE THE INTEGRATION OF HEALTHCARE SERVICES TO IMPROVE THE OVERALL HEALTH OF THE POPULATION OF FOCUS. OBJECTIVES INCLUDE COLLECTING PRIMARY PROVIDER CARE INFORMATION ON 75% OF CONSUMERS BY THE END OF YEAR ONE AND 100% BY THE END OF YEAR TWO. IN YEAR ONE, 50% OF CONSUMERS WILL RECEIVE PRIMARY CARE SCREENINGS, 75% IN YEAR TWO, 85% IN YEAR THREE, AND 95% IN YEAR FOUR. IN YEAR ONE, 50% OF CONSUMERS WILL RECEIVE CARE COORDINATION, 65% IN YEAR TWO, 75% IN YEAR THREE, AND 95% IN YEAR FOUR. AN ASSERTIVE COMMUNITY TREATMENT (ACT) TEAM WILL BE IMPLEMENTED AND SERVE 25 CONSUMERS IN YEAR ONE, 50 IN YEAR TWO, 75 IN YEAR THREE, AND 100 IN YEAR FOUR. BY YEAR THREE, 50% OF CONSUMERS WITH A BODY MASS INDEX (BMI) OUTSIDE NORMAL PARAMETERS WILL RECEIVE REFERRALS TO APPROPRIATE SUPPORTS, AND 75% WILL RECEIVE REFERRALS BY YEAR FOUR. THE SECOND GOAL IS TO INCREASE TIMELY ACCESS TO SERVICES AND EVIDENCE-BASED PRACTICES TO REDUCE THE NEED FOR MORE RESTRICTIVE LEVELS OF CARE FOR THE POPULATION OF FOCUS. TIME FROM REFERRAL TO SERVICE PROVISION WILL BE DECREASED TO 10 DAYS IN YEAR ONE AND DECREASED TO SEVEN DAYS IN YEAR TWO. SIXTY PERCENT OF CONSUMERS WILL RECEIVE AN EVIDENCE-BASED PRACTICED IN YEAR ONE, 70% IN YEAR TWO, 80% IN YEAR THREE, AND 90% IN YEAR FOUR. VALEO WILL PROVIDE SERVICES TO AN ADDITIONAL 20 INDIVIDUALS 65 YEARS AND OLDER IN YEAR ONE, 40 IN YEAR TWO, 60 IN YEAR THREE, AND 80 IN YEAR FOUR. ACCESS TO SERVICES WILL INCREASE, WITH THE NUMBER OF BILLABLE EVENTS INCREASING BY 10% IN YEAR TWO, 20% IN YEAR THREE, AND 25% IN YEAR FOUR. VALEO WILL ACCOMPLISH THESE OBJECTIVES BY UTILIZING SHORTER-TERM, MORE EFFECTIVE EVIDENCE-BASED PRACTICES, FULLY IMPLEMENTING SAME DAY ACCESS INTAKE, IMPLEMENTING JUST-IN-TIME PSYCHIATRIC PRESCRIBING, UTILIZING A NEW ELECTRONIC HEALTH RECORD WITH A CCBHC MODULE, IMPLEMENTING A FULLY INTEGRATED TREATMENT PLAN, UTILIZING A LEVEL OF CARE INSTRUMENT, ENHANCING AGENCY TRAININGS, EXPANDING THE USE OF SAFETY PLANS, AND IMPROVING ENGAGEMENT OF INDIVIDUALS 65 YEARS AND OLDER.

DRS TECHNOLOGIES TAKES PLEASURE IN PRESENTING THIS MULTI-BAND UNCOOLED RADIOMETER IMAGER (MURI) PROPOSAL FOR THE INSTRUMENT INCUBATOR PROGRAM (IIP) THAT WILL PROVIDE IMPROVED RADIOMETRIC IMAGING PERFORMANCE SUBSTANTIALLY REDUCE THE COST COMPLEXITY AND DEVELOPMENT TIME FOR FUTURE POLAR ORBITING EARTH OBSERVATION IMAGING RADIOMETER SENSORS. OUR PROPOSED SOLUTION LEVERAGES CONVENTIONAL LOW COST UNCOOLED MICROBOLOMETERS WITH A COMPACT PIEZO DRIVEN BACKSCAN AND OUR PATENTED TCOMP ALGORITHMS FOR IMPROVED RADIOMETRIC ACCURACY AND STABILITY. OUR SOLUTION ELIMINATES THE NEED FOR CRYOGENIC COOLING SOLVES THE PROBLEM OF IMAGE SMEAR ASSOCIATED WITH THE BOLOMETERS RELATIVELY LONG TIME CONSTANT WHILE SIMULTANEOUSLY ENSURING LOW NEDT. THE OBJECTIVE OF THE DRS PROPOSED MURI PROGRAM IS TO DEMONSTRATE THAT MODERN LOW COST LARGE AREA MICROBOLOMETER FPAS CAN BE UTILIZED TO PROVIDE NARROW BAND RADIOMETRICALLY ACCURATE IMAGING IN 8 LWIR BANDS FOR EARTH SCIENCE APPLICATIONS. THE POTENTIAL EARTH SCIENCE APPLICATIONS FOR THIS TECHNOLOGY ARE LAND SURFACE CLIMATOLOGY MEASUREMENT OF SOIL MOISTURE CONTENT MEASUREMENT OF ECOSYSTEM DYNAMICS VOLCANO MONITORING HAZARD MONITORING GEOLOGY AND SOILS. ON THE IIP PROGRAM DRS PLANS TO DESIGN BUILD TEST AND DEMONSTRATE AN UNCOOLED MICROBOLOMETER BREADBOARD SENSOR HARDWARE FOR EARTH OBSERVATION. OUR SCIENCE PARTNER ROCHESTER INSTITUTE OF TECHNOLOGY (RIT) WILL SUPPORT THE AIRBORNE DATA COLLECTS RADIOMETRIC DATA ANALYSIS AND COMPARISON TO LANDSAT 8 FOR A TRUTH REFERENCE AND THE SCIENCE IMPLEMENTATION ASPECT OF THE INSTRUMENT DATA COLLECTS. DRS/RIT WILL COLLECT AIRBORNE DATA FOR THREE PRIMARY APPLICATIONS IN 8 SPECTRAL BANDS. THE FIRST WILL ASSESS INITIAL DATA QUALITY AND CALIBRATION WITH KNOWN TARGETS DEPLOYED THE SECOND WILL DEMONSTRATE SCIENTIFIC PRODUCTS AVAILABLE OVER VEGETATIVE AND URBAN ENVIRONMENTS WHILE THE THIRD WILL DEMONSTRATE IMPORTANT ASPECTS OF VOLCANO MONITORING. ONE KEY TECHNOLOGICAL SOLUTION IS THE USE OF A PIEZO BACK-SCAN STAGE LOCATED AT THE IMAGE PLANE. THE PIEZO DRIVE VELOCITY WILL BE SET TO MATCH THE AIRCRAFT GROUND VELOCITY DURING IMAGE COLLECTION SUCH THAT THE IMAGE SMEAR FROM THE BOLOMETER S LONG TIME CONSTANT IS ELIMINATED. THIS IS CRITICAL FOR THE USE OF A STANDARD MICROBOLOMETER ARRAY WHICH TYPICALLY HAS ~14MSEC TIME CONSTANT. ANOTHER KEY FEATURE IS THE REAL-TIME RADIOMETRIC CORRECTION THAT WILL OCCUR DURING FLIGHT TO ACCOUNT FOR THE INSTRUMENT AND OPTICS TEMPERATURE CHANGES DURING OPERATION. THIS METHODOLOGY IS BEING UTILIZED BY DRS IN COMMERCIAL RADIOMETERS AND WILL BE IMPLEMENTED HERE TO ACCOUNT FOR INSTRUMENT/OPTICS TEMPERATURE CHANGES AND THEIR CONTRIBUTION TO RADIOMETRIC ERROR. THIS IS A DRAMATIC SHIFT FROM PRIOR RADIOMETERS BUILT FOR EARTH OBSERVATION IN THAT THOSE INSTRUMENTS TYPICALLY COOL THE OPTICS TO REDUCE RADIOMETRIC ERROR. WE ENVISION A SPACE INSTRUMENT USING 10 FPAS WITH UP TO 12 SPECTRAL FILTERS TO COVER A GROUND SWATH WIDTH OF 310KM FROM A 705KM ALTITUDE ORBIT AND A 100M GSD. FOR THIS AIRBORNE DEMO WE PLAN TO UTILIZE 4 FPAS WITH 8 SPECTRAL BAND FILTERS TO DEMONSTRATE THE KEY TECHNOLOGY WITHIN THE MORE LIMITED IIP PROGRAM BUDGET. FOR AN AIRBORNE DEMO USING 120MM EFL F/1 OPTICS AT 15 000FT ALTITUDE WILL HAVE A 0.65M GSD WITH TWO PARALLEL SWATH WIDTHS OF 414KM SEPARATED BY A GAP OF 619M. WE WILL SHOW DIRECT APPLICABILITY TO A SPACE INSTRUMENT AND HOW IT IS EASILY SCALABLE USING A STAGGER BUTTED ARRAY APPROACH. MUCH OF THE SAME HARDWARE COULD BE UTILIZED ON A SPACE VERSION OF THIS INSTRUMENT. PERIOD OF PERFORMANCE OF THIS IIP PROJECT IS EXPECTED TO BE 36 MONTHS. THE FIRST YEAR OF THE PROGRAM WILL INVOLVE THE DESIGN OF THE INSTRUMENT HARDWARE THE SECOND YEAR WILL BE THE BUILD OF THE COMPONENTS INTEGRATION AND ASSEMBLY OF THE INSTRUMENT AND THE THIRD YEAR WILL BE LABORATORY TEST OF THE INSTRUMENT AND AIRBORNE FIELD TESTING. ENTRY LEVEL TRL FOR THIS INSTRUMENT IS 3; EXIT LEVEL TRL AT THE END OF YEAR 3 WILL BE 6.

AKO IA KA HALE: THE HOUSE IS THATCHED

EVALUATION OF A DUAL PPAR AGONIST FOR TREATMENT OF ALZHEIMER'S DISEASE - SUMMARY ALZHEIMER’S DISEASE (AD) IS THE SIXTH LEADING CAUSE OF DEATH IN UNITED STATES, AFFECTING 5M PEOPLE, YET THIS INDICATION LACKS EFFECTIVE THERAPEUTICS. THE LEAD CO-INVESTIGATOR AT THE ACADEMIC PERFORMANCE SITE HAS DEVELOPED A NOVEL DUAL PEROXISOMAL PROLIFERATOR ACTIVATING RECEPTOR DELTA/GAMMA (PPARD/) AGONIST CALLED OL-003 (PREVIOUSLY AU9). THE PHASE I SBIR PROJECT DEMONSTRATED THAT OL-003 REDUCED AD-RELATED PATHOLOGIES, INCLUDING AMYLOID ACCUMULATION, TAU PHOSPHORYLATION AND NEUROINFLAMMATION, AND IMPROVED INSULIN SIGNALING, NEURONAL PLASTICITY AND BEHAVIORAL DEFICITS, WHILE EXHIBITING NO HEART OR LIVER TOXICITY IN 3XTG-AD MICE. THE COMPANY IS A PRIVATE PRECLINICAL BIOTECHNOLOGY COMPANY DEVELOPING NOVEL THERAPIES FOR MITIGATING AD. THE COMPANY HAS IN-LICENSED THE PATENT FOR OL-003 FROM OUR ACADEMIC PARTNER. STUDIES OUTLINED IN THIS PHASE II APPLICATION ARE DESIGNED TO TEST EFFICACY IN TWO ADDITIONAL ANIMAL MODELS AND ASSESS PHARMACOLOGY AND TOXICOLOGY IN GLP AND NON-GLP STUDIES. IF SUCCESSFUL, THIS INFORMATION WILL POSITION OL-003 FOR ADDITIONAL IND-ENABLING STUDIES (CMC IN PARTICULAR) TO SUBMIT AN IND APPLICATION AND BEGIN FIRST-IN- HUMAN CLINICAL TRIALS. THREE AIMS ARE PROPOSED. IN AIM 1, RESEARCH WILL BE PERFORMED USING THE TE4 MOUSE MODEL TO TEST THE EFFECTIVENESS OF OL-003 AGAINST TAU-DRIVEN NEUROPATHOLOGY IN THE CONTEXT OF APOE4, THE STRONGEST GENETIC RISK FACTOR FOR LATE-ONSET AD. STUDIES WILL INCLUDE MEASURING THE IMPACT OF OL-003 ON PHOSPHORYLATED TAU LEVELS, GLIOSIS AND NEURODEGENERATION. IN AIM 2, THE IMPACT OF OL-003 ON GLUCOSE UTILIZATION, MITOCHONDRIAL FUNCTION AND NEUROMETABOLISM IN THE BRAINS OF MICE WILL BE STUDIED. CURRENT RESEARCH SUPPORTS THE HYPOTHESIS THAT AD PROGRESSION IS DRIVEN BY ENERGY DYSREGULATION, MITOCHONDRIAL DEFECTS, AND BRAIN INSULIN RESISTANCE AND THE 5XFAD MODEL IS SUITABLE FOR THESE STUDIES. IN AIM 3, RESEARCH PERFORMED UNDER GLP CONDITIONS WILL DETERMINE IF OL-003 IS SAFE IN ACUTE AND 6-MONTH REPEAT DOSE TOXICITY STUDIES AS WELL AS GENOTOXICITY AND CARCINOGENICITY STUDIES. TOXICOKINETIC ANALYSIS AS WELL AS NEUROLOGIC, CARDIOVASCULAR, AND PULMONARY PARAMETERS WILL BE EVALUATED. ADDITIONAL IN VITRO STUDIES WILL ADDRESS DRUG-DRUG INTERACTION POTENTIAL, INCLUDING EFFECTS ON DRUG TRANSPORTER ACTIVITY AND EXPRESSION, AS WELL AS TARGET SELECTIVITY ASSAYS AGAINST OFF-TARGET NUCLEAR RECEPTORS AND METABOLITE IDENTIFICATION. UPON SUCCESSFUL COMPLETION OF THIS PROJECT, THE COMPANY WILL POSSESS A DATA PACKAGE OF IND-ENABLING RESEARCH THAT SHOULD BE ATTRACTIVE FOR A LICENSE DEAL OR PARTNERSHIP WITH A PHARMACEUTICAL COMPANY.

FUNDS BE USED TO COVER EXPENSES RELATED TO THE DISRUPTION OF CAMPUS OPERATIONS DUE TO CORONAVIRUS INCLUDING ELIGIBLE EXPENSES UNDER A STUDENT’S COST OF ATTENDANCE, SUCH AS FOOD, HOUSING, COURSE MATTER

OLIKO A LAU KA IKE, KNOWLEDGE BUDDING FORTH AND MULTIPLYING

CATAWBA AND IREDELL: MEDICATION ASSISTED TREATMENT PROGRAM - MCLEOD ADDICTIVE DISEASE CENTER IS APPLYING TO IMPLEMENT THE CATAWBA/IREDELL MEDICATION ASSISTED TREATMENT PROGRAM (CI-MAT) IN TWO WEST/CENTRAL NORTH CAROLINA COUNTIES WITH A POPULATION OF ~354,000, TARGETING THOSE WITH AN OUD AND THE 50% WITH CO-OCCURRING SUBSTANCE USE DISORDERS (SUD). WE WILL FOCUS ON MINORITY AND UNHOUSED CONSUMERS, WITH CLOSE TO TWO-THIRDS ALSO CHALLENGED BY UNTREATED TRAUMA AND BH CHALLENGES. LOCAL MANAGED CARE ORGANIZATION DATA FINDS THAT 2/3’S OF THOSE WITH OUD HAVE TRAUMA HISTORIES OF WHICH ONLY 20% ARE SPECIFICALLY TREATED FOR TRAUMA. THOSE WITH UNTREATED TRAUMA WERE 4X AS LIKELY TO LEAVE TREATMENT WITHIN 4-MONTHS AND HAD 5-7X THE NUMBER OF POSITIVE DRUG SCREENS DURING TREATMENT COMPARED TO THOSE WITHOUT TRAUMA HISTORY. 16% OF THE POPULATION HAS BEEN PRESCRIBED OPIOID MEDICATIONS, MUCH HIGHER THAN THE STATE AVERAGE. INCARCERATION RATES ARE AT OR ABOVE THE STATE AVERAGE AND FOSTER CARE DUE TO OUD AND RELATED ARE 10-25% HIGHER THAN THE STATE AVERAGE. THIS ALSO INDICATES A YOUNGER POPULATION TO BE SERVED. BEHAVIORAL HEALTH AND ADDITIONAL CHALLENGES HAVE SEVERELY LIMITED RETENTION IN MAT PROGRAMS FOR WHICH THIS PROGRAM IS DESIGNED TO IMPROVE. WE WILL SERVE A TOTAL OF 333 CONSUMERS, RANGING FROM 62-70 EACH YEAR. CONSUMERS WILL HAVE THE CHOICE OF AN OPIOID TREATMENT PROGRAM (OTP,) OR AN OFFICE-BASED OPIOID TREATMENT (OBOT), PROGRAM. CONSUMERS WILL RECEIVE APPROPRIATE MEDICATIONS PER THE PROVIDER TYPE WITH EMPHASIS ON REDUCING DIVERSION RISK. SERVICES WILL USE A RANGE OF EVIDENCE-BASED PRACTICES (EBP) FOR TREATMENT NEEDS, RECOVERY-BASED SERVICES FOR OUD AND ANY CO-OCCURRING SUD, A COMPREHENSIVE SCREENING AND ASSESSMENT PROCESS, WITH SERVICES SPECIFIC TO TRAUMA AND BEHAVIORAL HEALTH ISSUES WHEN DETECTED. PEER SUPPORT SERVICES WILL BE AVAILABLE TO ALL CONSUMERS AS WELL AS LINKAGE WITH LOCAL RECOVERY-BASED ORGANIZATIONS TO SUPPORT/MAINTAIN GAINS. WE WILL HAVE SPECIAL EMPHASIS ON THOSE UNHOUSED AND WILL HAVE SOBER HOUSING AVAILABLE AT MULTIPLE LOCATIONS. WE WILL EMPHASIZE RETENTION AND SHARING OF CONSUMERS BETWEEN THE PROGRAMS FOR THE BEST FIT FOR SERVICE. TO SUPPORT THIS, A LOW-THRESHOLD APPROACH WILL BE USED IF REQUESTED AND APPROPRIATE. WE WILL ADDRESS FOUR GOALS: 1) INCREASE USE AND INTEGRATION OF MEDICATION ASSISTED TREATMENT AND EVIDENCE-BASED SERVICES; 2) PROVIDERS WILL USE TRAUMA-INFORMED ASSESSMENTS AND SERVICES AND WILL BE SPECIFICALLY TREATING IDENTIFIED TRAUMA VIA EBP FOR CONSUMERS THAT CONSENT TO TRAUMA TREATMENT; 3) IMPROVE NETWORKING AND AVAILABILITY OF KEY RESOURCES AND POSITIVE SOCIAL ENGAGEMENTS (HOUSING, TRANSPORTATION, SOCIAL CONNECTEDNESS, ENGAGEMENT WITH RECOVERY SERVICES OUTSIDE OF THE TREATMENT CENTER); AND, 4) IMPROVE OUTREACH AND RETENTION EFFORTS TO INCREASE RESOURCES AND COMMON POLICY WITHIN AND BETWEEN PARTICIPATING PROVIDERS IN BOTH COUNTIES. EACH GOAL HAS FROM 3-8 OBJECTIVES THAT WILL FURTHER MEASURE THE GOAL STATEMENTS. TO DEVELOP A SUSTAINABLE MAT PROGRAM, GROUND IT IN DATA/INFORMATION, AND TO MAXIMIZE EFFICIENCY AND IMPACT, WE WILL DOCUMENT THE PROCESS BY COMPLETING AND UPDATING A NEEDS ASSESSMENT, NECESSARY DUE TO SERIOUS FRAGMENTATION AND COMMUNICATION ISSUES THAT IMPEDE OUD/SUD TREATMENT, REFERRALS, AND COMMUNICATION IN THE TARGET COUNTIES AND WIDELY HELD BELIEF SYSTEMS THAT STIGMATIZE OUD AS A NON-DISEASE PROCESS. AN IMPLEMENTATION PLAN TO ENSURE FIDELITY TO THE PROGRAM AND EBPS USED AS WELL AS PROCESSES FOR ALL STATED OBJECTIVES AND PERFORMANCE MEASURES. AN EVALUATION PLAN THAT WILL FOCUS ON DATA MANAGEMENT, PROCESS, FIDELITY, PERFORMANCE MEASURES, GOALS/OBJECTIVES, AND WILL INCLUDE A MIXED METHODS APPROACH. A SUSTAINABILITY PLAN CRITICAL TO MAINTAIN NEW LEVELS OF COMMUNICATION AND RESOURCE SHARING BETWEEN PROVIDERS AS WELL AS IMPROVING COMMUNITY UNDERSTANDING OF OUD AND NETWORKING RESOURCES.

THIS INVESTMENT AMENDMENT WILL PROVIDE SUFFICIENT ADDITIONAL FUNDS TO CONSTRUCT A 40,000 SQUARE-FOOT, HIGH-TECH BUSINESS INCUBATOR WITHIN INNOVATION PARK OF TALLAHASSEE. THE LEON COUNTY RESEARCH AND DEVELOPMENT AUTHORITY OVERSEES THE PARK AND WORKS WITH FLORIDA STATE UNIVERSITY, FLORIDA A&M UNIVERSITY AND TALLAHASSEE COMMUNITY COLLEGE, AMONG OTHER PUBLIC AND PRIVATE SECTOR ENTITIES. THE INCUBATOR, WILL AID IN THE FORMATION AND EXPANSION OF TECHNOLOGY BUSINESSES, DISSEMINATING TECHNOLOGIES TO EXISTING BUSINESSES, AND ESTABLISHING NEW BUSINESS OPERATIONS THROUGHOUT THE REGION. IT WILL SUPPORT LONG-TERM ECONOMIC RECOVERY IN THE AFTERMATH OF HURRICANE MICHAEL AND IS FUNDED UNDER EDA'S FY19 DISASTER SUPPLEMENTAL PROGRAM. THIS PROJECT WAS MADE POSSIBLE BY THE REGIONAL PLANNING EFFORTS LED BY THE APALACHEE REGIONAL PLANNING COUNCIL. EDA FUNDS APALACHEE REGIONAL PLANNING COUNCIL TO BRING TOGETHER THE PUBLIC AND PRIVATE SECTORS TO CREATE AN ECONOMIC DEVELOPMENT ROADMAP TO STRENGTHEN THE REGIONAL ECONOMY, SUPPORT PRIVATE CAPITAL INVESTMENT AND CREATE JOBS.

EDUCATION OF NATIVE HAWAIIANS

PURPOSE: CONGRESS ANNUALLY APPROPRIATES FUNDS FOR THE CAPITAL FUND, INCLUDING THE EMERGENCY AND NON-PRESIDENTIALLY DECLARED NATURAL DISASTER SET-ASIDE. THE ANNUAL APPROPRIATIONS ACTS ALSO PERMITS HUD TO USE A PORTION OF THE EMERGENCY AND NON-PRESIDENTIALLY DECLARED NATURAL DISASTER SET-ASIDE FOR SAFETY AND SECURITY FUNDING. HUD AWARDS EMERGENCY AND NON-PRESIDENTIALLY DECLARED NATURAL DISASTER GRANTS TO COVER CAPITAL NEEDS ARISING FROM EMERGENCIES AND NON-PRESIDENTIALLY DECLARED NATURAL DISASTERS OCCURRING IN THE SAME FEDERAL FISCAL YEAR (FFY). FOR EXAMPLE, PUBLIC HOUSING AGENCIES (PHAS) WITH CAPITAL NEEDS ARISING FROM A NON-PRESIDENTIALLY DECLARED NATURAL DISASTER IN FFY 2023 MAY ONLY RECEIVE FUNDS FROM THE FFY 2023 EMERGENCY AND NON-PRESIDENTIALLY DECLARED NATURAL DISASTER SET-ASIDE. APPROXIMATELY 2,770 PHAS SERVING NEARLY ONE MILLION UNITS, IN ALL 50 STATES AND TERRITORIES ARE ELIGIBLE TO APPLY. GRANTS ARE AWARDED ON A FIRST-COME, FIRST-SERVED BASIS UNTIL THE EMERGENCY AND NON-PRESIDENTIALLY DECLARED NATURAL DISASTER SET-ASIDE FUNDS ARE EXHAUSTED. INSURANCE COVERAGE, WHICH IS REQUIRED BY THE ANNUAL CONTRIBUTIONS CONTRACT (ACC), SHOULD BE A PHA’S PRIMARY SOURCE OF FUNDING FOR REPAIR OR REPLACEMENT COSTS ASSOCIATED WITH EMERGENCIES AND NON-PRESIDENTIALLY DECLARED NATURAL DISASTERS. PHAS ARE ELIGIBLE FOR PERMANENT RECONSTRUCTION ASSISTANCE THROUGH THE FEDERAL EMERGENCY MANAGEMENT AGENCY (FEMA) FOR PRESIDENTIALLY-DECLARED NATURAL DISASTERS. FEMA MAY ALSO PROVIDE EMERGENCY ASSISTANCE DURING NON-PRESIDENTIALLY DECLARED NATURAL DISASTERS FOR CERTAIN ACTIVITIES SUCH AS DEBRIS REMOVAL, DEMOLITION OF UNSAFE STRUCTURES, AND ANY ACTIONS NECESSARY TO REDUCE AN IMMEDIATE THREAT TO LIFE, PROPERTY, AND PUBLIC HEALTH AND SAFETY. ADDITIONAL INFORMATION ON THE PUBLIC HOUSING CAPITAL FUND IS LOCATED ON THE OFFICE OF CAPITAL IMPROVEMENTS WEBSITE: HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/PUBLIC_INDIAN_HOUSING/PROGRAMS/PH/CAPFUND ADDITIONAL INFORMATION ON PUBLIC HOUSING FUNDING CAN BE FOUND BY ACCESSING HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/PUBLIC_INDIAN_HOUSING/PROGRAMS/PH AND REVIEWING THE PUBLIC HOUSING DASHBOARD LINKED UNDER THE “DATA DASHBOARD AND ANALYTICS”.; ACTIVITIES TO BE PERFORMED: THE DEFINITIONS OF “EMERGENCY” AND “NON-PRESIDENTIALLY DECLARED NATURAL DISASTER” ARE USED IN DETERMINING ELIGIBILITY FOR EMERGENCY AND NON-PRESIDENTIALLY DECLARED NATURAL DISASTER GRANTS: • EMERGENCY: AN UNFORESEEN OR UNPREVENTABLE EVENT OR OCCURRENCE THAT POSES AN IMMEDIATE THREAT TO THE HEALTH AND SAFETY OF THE RESIDENTS (INCLUDING FIRE SAFETY) THAT MUST BE CORRECTED WITHIN ONE YEAR OF FUNDING. EXAMPLES OF EMERGENCIES ARE BOILER FAILURE, WATER INTRUSION CAUSING MOLD GROWTH, SEWER LINE FAILURE, AND SEVERE ELECTRICAL PROBLEMS. A PHA MUST BE ABLE TO DEMONSTRATE THAT IT HAS PROPERLY MAINTAINED STRUCTURES AND EQUIPMENT. • NON-PRESIDENTIALLY DECLARED NATURAL DISASTER: AN EXTRAORDINARY EVENT, SUCH AS AN EARTHQUAKE, FLOOD, OR HURRICANE, AFFECTING A PUBLIC HOUSING PROPERTY OWNED AND MANAGED BY A PHA, BUT EXCLUDING AREAS COVERED BY A PRESIDENTIALLY-DECLARED EMERGENCIES AND MAJOR DISASTERS UNDER THE ROBERT T. STAFFORD DISASTER RELIEF AND EMERGENCY ASSISTANCE ACT, AS THOSE AREAS ARE ELIGIBLE FOR FUNDING FROM THE FEDERAL MANAGEMENT AGENCY (FEMA). CAPITAL FUND DISASTER FUNDING CAN ONLY BE USED FOR ACTIVITIES AND COSTS ASSOCIATED WITH THE REPAIR OR REPLACEMENT OF A PUBLIC HOUSING PROJECT ONLY IF THE PUBLIC HOUSING PROJECT WAS DAMAGED BECAUSE OF AN EMERGENCY OR NON-PRESIDENTIALLY DECLARED NATURAL DISASTER. ACTIVITIES TO BE PERFORMED ARE TO PROVIDE EMERGENCY SAFETY MEASURES FOR PUBLIC HOUSING RESIDENTS THAT CAN INCLUDE RELOCATION AND THE COST TO PROVIDE TEMPORARY HOUSING TO PUBLIC HOUSING RESIDENTS UNTIL PUBLIC HOUSING UNITS CAN BE REPAIRED AND CAN BE COVERED BY THE EMERGENCY AND NON-PRESIDENTIALLY DECLARED NATURAL DISASTER GRANT (SUCH AS HOTEL, MOVING VAN RENTAL, TEMPORARY STORAGE, BOXES.). ACTIVITIES TO BE PERFORMED ARE CONTAINED WITHIN THE GRANTEE’S APPROVED GRANT APPLICATION. EXAMPLES OF TYPICAL EMERGENCY SITUATIONS CAN INCLUDE BUT NOT LIMITED TO ELEVATOR FAILURES IN ELDERLY BUILDINGS, WATER PIPE BURST AND FLOODING SITUATIONS, SEWAGE BACKUP AND INTRUSIONS, SEISMIC ACTIVITY DAMAGE, TREE ROOT INTRUSION, FAILED HVAC SYSTEM, AND BOILER LOSS DURING COLD WEATHER. ; EXPECTED OUTCOMES: THE EXPECTED OUTCOMES FOR PUBLIC HOUSING EMERGENCY/DISASTER CAPITAL FUNDS ARE THE IMMEDIATE SAFETY MEASURES FOR PUBLIC HOUSING RESIDENTS AND THE REMEDIATION OF THE SPECIFIC APPROVED EMERGENCY/DISASTER PROJECT. THE MEASURABLE OUTCOME OF THIS GRANT IS THAT HUD WILL BE ABLE TO TRACK THE AMOUNT OF DOLLARS SPENT ON EMERGENCY AND DISASTER ELIGIBLE ACTIVITIES BASED ON THE APPROVED GRANT APPLICATION. ; INTENDED BENEFICIARIES: THE INTENDED BENEFICIARIES FOR PUBLIC HOUSING EMERGENCY/DISASTER CAPITAL FUNDS ARE LOW-INCOME PUBLIC HOUSING RESIDENTS.; SUBRECIPIENT ACTIVITIES: THE RECIPIENT DOES NOT INTEND TO SUBAWARD FUNDS.

KAHUA KUKULU: FOUNDATION FOR BUILDING

FINANCIAL ASSISTANCE AWARD

ENHANCED EARTH SYSTEM TEACHING THROUGH REAL EARTH INQUIRY

PROTECTING AND IMPROVING PUBLIC HEALTH GLOBALLY: BUILDING AND STRENGTHENING PUBLIC HEALTH IMPACT, SYSTEMS, CAPACITY, AND SECURITY IN SIERRA LEONE

DEVELOPMENT OF A COLORIMETRIC SENSOR FOR DETECTION OF CEREBROSPINAL FLUID LEAKS - PROJECT SUMMARY CHEMELEON, INC. IS A NYC-BASED STARTUP THAT IS DEVELOPING A NOVEL COLORIMETRIC BIOSENSOR THAT RAPIDLY DIAGNOSES CEREBROSPINAL FLUID (CSF) LEAKS AT THE POINT-OF-CARE (POC), SUCH AS BY DOCTORS TO DIAGNOSE TRAUMATIC BRAIN INJURY (TBI) PATIENTS IN THE EMERGENCY DEPARTMENT (ED), OR THE EMERGENCY MEDICAL TECHNICIAN (EMT) IN THE AMBULANCE, OR DURING INTRAOPERATIVE AND POST-OPERATIVE CARE FOR SPINAL AND OTOLARYNGOLOGICAL SURGERIES. CSF LEAKS OCCUR WHEN THE FLUID THAT CUSHIONS THE BRAIN AND SPINE ESCAPES THROUGH RUPTURES IN THE SURROUNDING MEMBRANES. THESE LEAKS ARE LARGELY CAUSED BY TBIS BUT ARE ALSO A RISK DURING SPINAL SURGERIES, OTOLARYNGOLOGICAL SURGERIES, LUMBAR PUNCTURES AND EPIDURALS AND THEY CAN ALSO BE SPONTANEOUS. DISTINGUISHING CSF LEAKS FROM OTHER BODILY FLUIDS IS A WELL-KNOWN PROBLEM FOR ED DOCTORS, EMTS AND SURGEONS AS THE LEAKS OFTEN PRESENT AS UNILATERAL RHINORRHEA OR OTORRHEA, A CLEAR WATERY DISCHARGE FROM THE NOSE OR EAR, OR AS A MIXTURE WITH BLOOD AND OTHER FLUIDS DURING SPINAL SURGERY. CURRENTLY THERE ARE NO POC DIAGNOSTICS FOR CSF LEAKS AND EXISTING METHODS REQUIRE PATIENT SAMPLES TO BE SENT TO THIRD-PARTY LABORATORIES FOR RESULTS THAT CAN TAKE 4-7 DAYS. TREATMENT DELAYS OR MISDIAGNOSES SIGNIFICANTLY INCREASE THE RISK FOR LIFE-THREATENING MENINGITIS, INFECTIONS AND STROKE. PATIENTS WITH CSF RHINORRHEA THAT DEVELOP MENINGITIS HAVE ALSO HAVE MUCH HIGHER MORBIDITY RATES. ADDITIONALLY, THE WEEKLONG STAY NOT ONLY CAUSES SIGNIFICANT DISTRESS AND DISCOMFORT FOR THE PATIENT, BUT ALSO LEADS TO RADICALLY HIGHER HEALTHCARE COSTS. IN THIS DIRECT-TO-PHASE II PROPOSAL, CHEMELEON AIMS TO ADVANCE CSF LEAK DIAGNOSIS BY DEVELOPING A NOVEL, INEXPENSIVE BIOSENSOR THAT REQUIRES NO ADDITIONAL EQUIPMENT OR PERSONNEL TRAINING THAT CAN PROVIDE RESULTS IN MINUTES, ENABLING MEDICAL PROFESSIONALS TO MAKE TIME-SENSITIVE DECISIONS. CHEMELEON HAS ALREADY SUCCESSFULLY DEVELOPED A PROTOTYPE BINDING-INDUCED NANOSTRUCTURED DYNAMIC SURFACE (BINDS) ASSAY THAT BINDS THE CSF PROTEIN BIOMARKER, BETA-2-TRANSFERRIN (B2TR). THIS BINDS PLATFORM TECHNOLOGY INTEGRATES NANOPHOTONIC REPORTER SURFACES WITH B2TR-SPECIFIC APTAMER RECEPTORS, WHERE BINDING OF B2TR TO THE SENSOR SURFACE ALTERS THE SURFACE ENERGY PRODUCING A VIBRANT COLOR CHANGE THAT IS VISIBLE TO THE NAKED EYE. PROOF-OF- CONCEPT EXPERIMENTS REVEALED THAT CHEMELEON’S BINDS CSF ASSAY COULD DETECT 1 ΜG/ML OF B2TR IN 10 MINUTES, WHICH IS HIGHER THAN THE 4-5 ΜG/ML FOUND IN CSF. FOR DIRECT-TO-PHASE II STUDIES, THE CSF SENSOR WILL BE FURTHER DEVELOPED TO ACHIEVE THE HIGH SPECIFICITY, HIGH SENSITIVITY AND LOW READOUT TIME REQUIRED FOR USE IN CLINICAL AND FIELD SETTINGS. CHEMELEON WILL FOCUS ON (1) OPTIMIZING SENSOR PERFORMANCE TO RAPIDLY DISTINGUISH CSF FROM NASAL FLUID AND BLOOD SAMPLES, (2) FINALIZING MANUFACTURING PROCESSES FOR EFFICIENT SCALE-UP, AND (3) DESIGNING AND TESTING A COMMERCIAL IN VITRO DIAGNOSTIC PROTOTYPE. CHEMELEON’S CSF SENSOR WILL PROVIDE ADVANCEMENTS IN DECISION-MAKING FOR HEAD TRAUMA, SPINAL AND OTOLARYNGOLOGICAL SURGICAL CASES AND PRESENT A MODULAR PLATFORM FOR THE DEVELOPMENT OF OTHER HEALTHCARE DIAGNOSTICS.

SBIR DIRECT PHASE II: NATURE INSPIRED BIPHASIC GLUE FOR DURA REPAIR - PROJECT SUMMARY THE GLOBAL MARKET FOR SURGICAL ADHESIVES AND SEALANTS WAS VALUED AT USD 4.09 BILLION IN 2018 AND PROJECTED TO REACH USD 7.89 BILLION IN 2026 AT A CAGR OF 9.7%. SURGERIES IN CENTRAL NERVOUS SYSTEM (CNS) ACCOUNTED FOR THE LARGEST MARKET SHARE IN THE YEAR 2016, OWING TO A HIGH PREVALENCE OF NEURAL DISORDERS GLOBALLY. TO NAME A FEW NUMBERS, THERE ARE 600K CRANIAL SURGERIES, 1.2 MILLION LUMBAR SURGERIES, AND 1.7 MILLION TRAUMATIC BRAIN INJURIES IN THE U.S. ALONE. SEALANTS ARE THE NUMBER ONE CHOICE IN CNS SURGERIES, SUCH AS CSF LEAK PREVENTION AND DURA REPAIR IN BRAIN SURGERIES, OVER TRADITIONAL TISSUE CLOSURE METHODS SUCH AS WIRES, SUTURES, AND STAPLES. HOWEVER, TRADITIONAL SEALANTS SUCH AS DURASEAL® AND TISSEEL® ARE FAR FROM SATISFACTORY IN BRAIN SURGERIES DUE TO THEIR WEAK WET TISSUE ADHESION STRENGTH AND RAPID DEGRADATION AND EVEN WHEN USED AS ADJUVANTS TO OTHER TISSUE GRAFTS OR DURAPLASTY DEVICES. AS A RESULT, DEMAND FOR SURGICAL SEALANTS AND ADHESIVES FOR BRAIN SURGERIES HAS RISEN EXPONENTIALLY, GIVING ALEO BME’S BP GLUE PRODUCT A HUGE OPPORTUNITY TO PENETRATE THIS EVER-INCREASING NICHE MARKET. ALEO BME HAS MADE SIGNIFICANT PROGRESS IN DISCOVERING AN INTERESTING TISSUE ADHESION MECHANISM FOR THE DEVELOPMENT OF BP GLUE AND ESTABLISHED THE FEASIBILITY OF USING BP GLUE FOR CEREBROSPINAL FLUID (CSF) LEAK PREVENTION AND DURA REPAIR IN RAT AND PIG CRANIOTOMY MODELS. BP GLUE IS AN A-B FORMULATION COMPOSED OF FULLY SYNTHETIC AND DEGRADABLE WATER-BORNE POLYURETHANE (WPU) NANOPARTICLE DISPERSION SOLUTIONS WITH COUNTERIONS. BP GLUE ADHESION MECHANISM IS A UNIQUE COMBINATION OF ENGLISH-IVY ADHESION MECHANISM THROUGH WHICH WPU (+) AND WPU (-) NANOPARTICLES PENETRATE AND PERMEATE ONTO TISSUE SURFACES AND THEN IONICALLY CROSSLINKED TO FORM A MECHANICAL INTERLOCKING AT THE MATERIAL/TISSUE INTERFACE FOR TISSUE ADHESION AND PARTICLE PACKING THEORY THROUGH WHICH PARTICLE SIZE MISMATCH (LARGE WPU (+) AND SMALL WPU (-)) PLAYS A SIGNIFICANT ROLE IN ENHANCING PARTICLE PACKING AND INTERFUSION FOR IMPROVING ADHESIVE AND COHESIVE STRENGTHS OF THE ADHESIVE (FIG. 1). BP GLUE IS THE FIRST AQUEOUS, SUPER-STRONG, AND ELASTIC TISSUE ADHESIVE DEMONSTRATING EQUIVALENT LAP SHEAR STRENGTHS TO DERMABOND® (CYANOACRYLATE) WITHOUT USING TOXIC CHEMICAL CROSSLINKING. IT IS EXPECTED THAT THE USE OF BP GLUE MAY ELIMINATE THE USE OF OTHER TISSUE GRAFTS OR DURAPLASTY DEVICES IN BRAIN SURGERIES AND MAY ALSO ELIMINATE THE REVISIONAL SURGERIES TO FIX THE POST-SURGICAL CSF LEAKS. THE OBJECTIVES OF THIS SBIR DIRECT PHASE II ARE TO SCALE-UP THE MANUFACTURING PROCESSES OF BP GLUE, DEVELOP BP GLUE DELIVERY TOOL, VALIDATE THE SCALE-UP PRODUCTIONS, UNDERSTAND THE IMPACT OF STERILIZATION ON BP GLUE FUNCTIONS, EVALUATE ITS EFFICACY FOR DURA REPAIR IN A CANINE CRANIOTOMY, AND FURTHER RIGOROUSLY VALIDATE THE BIOCOMPATIBILITY OF BP GLUE FOLLOWING ISO 10993 TOWARD FDA SUBMISSIONS. THE SUCCESS OF THIS PHASE II WILL HELP ALEO BME SECURE FURTHER INVESTMENTS AND DEVELOP BUSINESS PARTNERSHIPS AND WILL PAVE THE WAY TOWARD A SUCCESSFUL FDA PREMARKET APPROVAL (PMA) APPLICATION AND TECHNOLOGY COMMERCIALIZATION.

WASTE DISPOSAL GRANTS (MANDATORY FARM BILL)

CDFI RAPID RESPONSE PROGRAM AWARD

THIS PROJECT INVOLVES THE REPLACEMENT OF 63 CLASS 8 TRACTORS OWNED BY UPS AND OPERATING IN IOWA, KANSAS, MISSOURI AND NEBRASKA. FIFTY (50) OF THE TRACTORS FROM THE STATES OF IA, MO AND NE WILL BE REPLACED WITH NEW DIESEL POWERED TRACTORS AND THIRTEEN (13) OPERATING IN KS WITH CNG POWERED TRACTORS. AT THE COMPLETION OF THE PROJECT DIESEL EMISSIONS WILL BE REDUCED BY APPROXIMATELY 49,127 LIFE TIME TONS.

IN NOVEMBER OF 2021, THE LEON COUNTY SHERIFF’S OFFICE (LCSO) RELEASED THE ANATOMY OF A HOMICIDE REPORT OUTLINING THE FINDINGS OF AN EXPLORATORY REVIEW OF HOMICIDES THAT OCCURRED IN LEON COUNTY FROM 2015 TO 2020. IN RESPONSE TO THE FINDINGS, THE LCSO ACKNOWLEDGED THAT VIOLENCE CANNOT BE SOLVED BY LAW ENFORCEMENT ALONE AND ADVOCATED FOR ADDITIONAL RESEARCH, IMPROVED DATA COLLECTION AND ANALYSIS, INCREASED COLLABORATION AND INFORMATION SHARING BETWEEN AGENCIES, PROVIDERS, AND THE COMMUNITY, AS WELL AS EVIDENCE-BASED SOLUTIONS THAT ARE COMMUNITY INFORMED. LCSO PROPOSED, AND RECEIVED BROAD COMMUNITY AND GOVERNMENTAL SUPPORT, TO ESTABLISH THE COUNCIL ON THE STATUS OF MEN AND BOYS (CSMB) TO PROVIDE A ROADMAP TO REDUCE HOMICIDES AND NON-FATAL SHOOTINGS IN TALLAHASSEE-LEON COUNTY BY BRINGING ALL STAKEHOLDERS AND RESOURCES TOGETHER TO IMPLEMENT A UNIFIED OPERATIONAL STRATEGY FOR VIOLENCE PREVENTION AND INTERVENTION. LCSO SUBMITS THIS APPLICATION TO REQUEST FEDERAL FUNDS TO LEVERAGE WITH EXISTING LOCAL RESOURCES AND FUNDING TO IMPLEMENT A COMPREHENSIVE COMMUNITY VIOLENCE INTERVENTION PROGRAM. AMOUNT REQUESTED: $1,495,663 CATEGORY 2: CVIPI PLANNING AND IMPLEMENTATION FOR CITY/COUNTY/TRIBAL GOVERNMENTS SERVICE AREA / INTENDED BENEFICIARIES: LEON COUNTY, FLORIDA WITH A FOCUS ON SPECIFIC ZIP CODES; INDIVIDUALS WHO RESIDE, FREQUENT, OR SOCIALIZE IN HIGH CRIME AREAS OF THE COUNTY; AND THOSE AT HIGH-RISK OF RESORTING TO VIOLENCE ACCORDING TO A RECENT EVIDENCE-BASED STUDY OF LEON COUNTY HOMICIDES AND FIREARM VIOLENCE (COPY OF REPORT ENCLOSED). GOAL: IDENTIFY AND ADDRESS THE CONDITIONS, DYNAMICS, AND CORE ISSUES THAT CONTRIBUTE TO THE CYCLE OF VIOLENCE IN HIGH-RISK COMMUNITIES AND DISRUPT/ELIMINATE THE OPPORTUNITIES AND CONDITIONS THAT LEAD TO VIOLENCE. PRIORITY CONSIDERATION: LEON COUNTY REQUESTS PRIORITY CONSIDERATION UNDER THE FOLLOWING: #1 SUPPORTING EXECUTIVE ORDER 13985, ADVANCING RACIAL EQUITY AND SUPPORT FOR UNDERSERVED COMMUNITIES THROUGH THE FEDERAL GOVERNMENT (REF: PROPOSAL NARRATIVE PGS.8-9) #2 SUPPORTING COMMUNITIES WITH HIGH/RISING LEVELS OF HOMICIDES PER CAPITA (REF: PROPOSAL NARRATIVE PGS.1-4, AND THE ENCLOSED ANATOMY OF A HOMICIDE PROJECT REPORT PG.18) #3 DEMONSTRATED EXISTING PARTNERSHIPS WITH MULTIDISCIPLINARY TEAM OF STAKEHOLDERS (REF: PROPOSAL NARRATIVE PGS.5-6, 8, 12-13, AND THE ENCLOSED FILE TITLED “FY22_LEONCVIPI_PLANNINGTEAM”)

SBIR PHASE II: DIGITAL REHABILITATION PLATFORM FOR HIGHER EDUCATION, MENTAL HEALTH, AND WORKFORCE READINESS

HE OHANA PUNANA LEO "STRENGTHENING FAMILY ENGAGEMENT IN LANGUAGE NESTS"

DESCRIPTION: THIS AGREEMENT WILL PROVIDE ASSISTANCE TO LEONARDO ACADEMY INC. TO PROMOTE THE REDUCTION OF DIESEL EMISSIONS IN ELIZABETH, NJ, AND RAISE AWARENESS ABOUT THE BENEFITS OF DIESEL EMISSION REDUCTION PROJECTS AMONG THE PUBLIC AND COMPANIES THAT OWN OR OPERATE DIESEL FLEETS. ACTIVITIES: THE PROJECT WILL FOCUS ON THE REPLACEMENT OF DIESEL TERMINAL TRACTORS WITH ZERO-EMISSION ELECTRIC TRACTORS, AND THE PURCHASE OF FAST OFFBOARD CHARGING CABINETS TO PROVIDE A CHARGING POINT FOR THE ELECTRIC TERMINAL TRACTORS. OUTCOMES: REPLACING DIESEL TRACTORS WITH ELECTRIC TRACTORS IS EXPECTED TO IMPROVE LOCAL AIR QUALITY BY REDUCING EMISSIONS OF DIESEL PARTICULATE MATTER (PM) AND OTHER POLLUTANTS, SUCH AS NITROGEN OXIDES (NOX), HYDROCARBONS (HC), AND CARBON MONOXIDE (CO). MEMBERS OF THE PUBLIC WHO LIVE AND WORK NEAR ELIZABETH NJ ARE EXPECTED TO BENEFIT FROM THIS PROJECT BY EXPERIENCING IMPROVED LOCAL AIR QUALITY AS A RESULT OF POLLUTANT EMISSIONS REDUCTION. APM TERMINAL, AS THE PROJECT PARTNER AND DIESEL VEHICLE FLEET OWNER, WILL COMPLETE THE PURCHASE OF THE ELECTRIC TRACTORS AND CHARGING CABINETS CONSISTENT WITH ELIGIBILITY AND PROJECT REQUIREMENTS. SUBRECIPIENT:

HAWAIIAN LANGUAGE TELEVISION BROADCAST VIDEO TRAINING DEVELOPMENT AND BROADCAST

THE ENDELEO INSTITUTE, INC. UPWARD BOUND PROGRAM

CARES ACT - HIGHER EDUCATION EMERGENCY RELIEF (STRENGTHENING INSTITUTIONS)

LEONARDO ACADEMY WILL ADMINISTER A GRANT PROGRAM THROUGH A REGIONAL COLLABORATION THAT WILL PROVIDE FUNDING FOR CLEAN DIESEL PROJECTS INVOLVING MEDIU

AMERICAN RECOVERY AND REINVESTMENT ACT - PCC - ACCESSAMERICA VIDEO REMOTE INTERPRETING

DOMESTIC WATER GRANTS - REGULAR

PURPOSE: ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING/CONGRESSIONAL DIRECTED SPENDING AWARDS ARE AUTHORIZED UNDER THE CONSOLIDATED APPROPRIATIONS ACT, 2022 PUBLIC LAW 117-328 AND THE EXPLANATORY STATEMENT FOR DIVISION L OF THAT ACT. PROJECTS SELECTED FOR COMMUNITY PROJECT FUNDING/CONGRESSIONAL DIRECTED SPENDING ARE LISTED IN THE JOINT EXPLANATORY STATEMENT (JES) THAT ACCOMPANIES A SPECIFIC FISCAL YEAR’S APPROPRIATIONS ACT OR CONGRESSIONAL RECORD. THE JES LISTS PROJECT, RECIPIENT, STATE, AMOUNT AND CONGRESSIONAL SPONSOR.; ACTIVITIES TO BE PERFORMED: ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING AWARD PROJECTS INCLUDE A WIDE VARIETY OF ACTIVITIES THAT RESULT IN ECONOMIC DEVELOPMENT OR COMMUNITY DEVELOPMENT OUTCOMES. HUD WILL NOT KNOW THE FULL SCOPE OF THE PROJECT UNTIL THE RECIPIENT SUBMITS THE REQUIRED PROJECT NARRATIVE AND CONFIRMS ALIGNMENT WITH THE LANGUAGE AS PROVIDED IN THE CONGRESSIONAL RECORD. TO FIND THE DETAILS OF THE GRANT AWARD AS WRITTEN WITHIN THE CONGRESSIONAL RECORD USE THE FOLLOWING LINK AND PATH SELECTIONS TO GET TO THE DESCRIPTION OF THE ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING GRANTS HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/EDI-GRANTS, SELECT THE FISCAL YEAR OF INTEREST, SCROLL DOWN TO PROGRAM LAWS AND REGULATIONS, UNDER FISCAL YEAR 20XX CONSOLIDATED APPROPRIATIONS ACT, 20XX: CONGRESSIONAL RECORD (JOINT EXPLANATORY STATEMENT).; EXPECTED OUTCOMES: COMPLETION OF THE PROJECT AS DESCRIBED IN THE JOINT EXPLANATORY STATEMENT (JES) PROJECT DESCRIPTION AND SUBSEQUENT APPROVED PROJECT NARRATIVE.; INTENDED BENEFICIARIES: THE PROJECT BENEFICIARIES ARE THE INDIVIDUALS AND/OR ORGANIZATIONS THAT ARE AWARDED GRANT FUNDS OR SERVED BY THE ENTITIES THAT ARE AWARDED GRANT FUNDS AS IDENTIFIED IN THE JES RECIPIENT OR PROJECT DESCRIPTION SECTIONS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

SBIR PHASE II: SERENDIPITOUS SEARCH SYSTEM USING LATERAL ANALOGY TO MATCH POTENTIAL SOLUTIONS TO UNMET NEEDS:FEASIBILITY STUDY BASED ON SCREENING AP

DESCRIPTION:THE AGREEMENT PROVIDES FUNDING TO LEONARDO ACADEMY. SPECIFICALLY, THE RECIPIENT WILL REPLACE OLDER, DIESEL YARD TRUCKS WITH ELECTRIC YARD TRUCKS WHICH WILL REDUCE EMISSIONS OF DIESEL PARTICULATE MATTER, NITROGEN OXIDES AND EXPOSURE TO DIESEL AIR TOXICS IN THE PORT OF ELIZABETH IN UNION COUNTY, NEW JERSEY.ACTIVITIES:THE ACTIVITIES INCLUDE SCRAPPING DIESEL YARD TRUCKS AND PURCHASING ALL-ELECTRIC YARD TRUCKS ALONG WITH INDUCTIVE CHARGING THROUGH A COMPETITIVE PROCUREMENT PROCESS. THE PROJECT PARTNERS WILL COORDINATE THE DESTRUCTION AND RECYCLING OF THE YARD TRUCKS. SUBRECIPIENT:A SUBAWARD WILL BE GIVEN TO THE SUBRECIPIENT, APM TERMINAL. THE ACTIVITIES TO BE IMPLEMENTED THROUGH THE SUBAWARD ENTAIL REPLACING DIESEL-POWERED CARGO HANDLING EQUIPMENT CALLED YARD TRUCKS WITH ALL-ELECTRIC YARD TRUCKS. THE GRANT WILL BE MANAGED BY LEONARDO ACADEMY WHO WILL OVERSEE THE IMPLEMENTATION OF THE AWARD. THE CARGO HANDLING EQUIPMENT OWNERS, AS SUBRECIPIENTS, WILL PROCURE REPLACEMENT ELECTRIC YARD TRUCKS IN COMPLIANCE WITH PROCUREMENT RULES, PERMANENTLY DISABLE AND DECOMMISSION OLD NON-ROAD DIESEL YARD TRUCKS AND SUBMIT ALL REQUIRED DOCUMENTATION TO LEONARDO ACADEMY, WHO WILL THEN SUBMIT THEM TO EPA. APM TERMINALS AND LEONARDO ACADEMY WILL MAKE QUARTERLY AND ANNUAL REPORTS TO EPA TO SUMMARIZE THE STATUS OF THE SCRAPPAGE AND PURCHASE OF THE CARGO HANDLING EQUIPMENT.OUTCOMES:THE ANTICIPATED DELIVERABLES INCLUDE THE SCRAPPAGE OF OLDER DIESEL YARD TRUCKS WITH ALL-ELECTRIC YARD TRUCKS AND THE INSTALLATION OF INDUCTIVE CHARGERS. THE EXPECTED OUTCOMES INCLUDE ELIMINATING EMISSIONS FROM YARD TRUCKS, REDUCING PARTICULATE MATTER EMISSIONS AND NITROGEN OXIDES. THE INTENDED BENEFICIARIES INCLUDE THE RESIDENTS OF THE NEAR-PORT COMMUNITIES IN ELIZABETH, NEW JERSEY AND THE PORT WORKFORCE.

KANI KUAOLA: AMPLIFYING LIVELIHOODS IN MELE

AWARDING CAREER EDUCATORS IN STEM: LEVERAGING SIMULATION TECHNOLOGY, INSTITUTIONAL MISSION, AND FIELD EXPERIENCES TO ADDRESS CRITICAL TEACHER SHORTAGES

THIS PROPOSAL FOCUSES ON ADVANCING SENSORS USED FOR AIR QUALITY FORECASTING BY OBSERVING OZONE AND TRACE GASES VIA IMAGING SPECTROMETERS SUCH AS THE PANCHROMATIC FOURIER TRANSFORM SPECTROMETER (PANFTS) INSTRUMENT. SOLAR REFLECTED RADIANCES OF THESE

ENDELEO INSTITUTE-EDUCATIONAL OPPORTUNITY CAREER CENTER PROGRAM

COMMUNITY-BASED ABSTINENCE EDUCATION

COMBINATION WATER & WASTE DISPOSAL GRANTS - REGULAR

KA LĀʻAU ʻŌʻŌ AIMS TO INCREASE THE ORGANIZATIONAL CAPACITY OF THE ‘AHA PŪNANA LEO THROUGH LEADERSHIP DEVELOPMENT AND INTERNATIONAL ACCREDITATION.

THE OVERALL OBJECTIVE OF THE ACTION IS TO CONTRIBUTE TO A SUSTAINED IMPROVEMENT OF LIVING CONDITIONS STABILITY AND SECURITY IN THE RURAL POPULATION

PROJECT TITLE NOT PROVIDED

NEW COMMUNICATION TECHNOLOGY FOR SUDDENLY SPEECHLESS HOSPITALIZED PATIENTS

NOVEL AND FUNCTIONALLY SELECTIVE 5-HT2C RECEPTOR AGONIST FOR TREATING ALCOHOL USE DISORDER - PROJECT SUMMARY THE GOAL OF THIS PROJECT IS TO CONFIRM AND EXTEND THE DRUG CANDIDACY OF KB128 AS A NOVEL THERAPEUTIC MEDICATION FOR ALCOHOL USE DISORDER (AUD), A COMMON AND DEVASTATING ILLNESS WITH INADEQUATE TREATMENT OPTIONS. CURRENT DRUGS APPROVED BY THE FDA FOR AUD ARE CHARACTERIZED BY LOW EFFICACY AND STEREOTYPICAL SIDE EFFECTS THAT REDUCE TREATMENT ADHERENCE. THE 5-HT2C RECEPTOR IS A VALIDATED THERAPEUTIC DRUG TARGET FOR AUD. HOWEVER, PREVIOUS ATTEMPTS TO DESIGN SELECTIVE 5-HT2C RECEPTOR LIGANDS HAVE BEEN PLAGUED BY UNDESIRABLE OFF-TARGET EFFECTS, INCLUD- ING ABERRANT ACTIVATION OF 5-HT2A (HALLUCINATIONS) AND 5-HT2B (VALVULOPATHY), OR A LACK FUNCTIONAL SELECTIVITY BY ACTIVATING BOTH GQ SIGNALING (MEDIATING THE PUTATIVE THERAPEUTIC EFFECT) AND Β-ARRESTIN SIGNALING (LEADING TO RECEP- TOR INTERNALIZATION AND ATTENUATION OF SIGNAL). PRODUCTION AND COMMERCIALIZATION OF A SAFE AND SELECTIVE 5-HT2C RECEPTOR AGONIST WITH FUNCTIONAL GQ BIAS, NEGLIGIBLE Β-ARRESTIN RECRUITMENT, AND NO HALLUCINOGENIC OR CARDIOTOXIC LIABILITIES ASSOCIATED WITH 5-HT2A AND 5-HT2B RECEPTOR ACTIVATION WOULD BE A MARKET-CHANGING DIFFERENTIATOR; NO 5- HT2C AGONIST COMMERCIALIZED THUS FAR EXHIBITS THIS PROFILE. KÜLEON, LLC HAS DEVELOPED A PROPRIETARY PLATFORM OF MOLECULAR SCAFFOLDS WITH UNIQUE RECEPTOR DOCKING PROFILES. OUR PRELIMINARY STUDIES DEMONSTRATE LEAD CANDIDATE KB128 EXHIBITS HIGH SELECTIVITY FOR 5-HT2C, GQ-MEDIATED SIGNALING BIAS WITH MINIMAL Β-ARRESTIN RECRUITMENT, FAVOR- ABLE METABOLIC PROFILE, NO HALLUCINOGENIC OR CARDIOTOXIC LIABILITIES, AND EFFICACY IN A PILOT AUD STUDY IN RODENTS. OUR PHASE I OBJECTIVE FOR KB128 IS TO DEMONSTRATE PRECLINICAL EFFICACY IN MORE EXTENSIVE AUD BEHAVIORAL MODELS, FAVORABLE PHARMACOKINETICS, AND NO OFF-TARGET TOXICITY. WE WILL ACCOMPLISH THIS IN THE FOLLOWING TWO AIMS. (1) DEMONSTRATE KB128’S ABILITY TO ATTENUATE ALCOHOL SELF-ADMINISTRATION AND STRESS-INDUCED RELAPSE IN VALIDATED RO- DENT MODELS. 5-HT2C RECEPTOR SIGNALING HAS BEEN IMPLICATED IN THE DEVELOPMENT AND MAINTENANCE OF AUD, AND PRIOR STUDIES HAVE SHOWN THAT 5-HT2C RECEPTOR AGONISTS CAN SIGNIFICANTLY DECREASE ALCOHOL CONSUMPTION IN BOTH RODENTS AND HUMANS. STRESS-INDUCED RELAPSE AS A SECONDARY READOUT OF A SELF-ADMINISTRATION STUDY CAN PROVIDE AN INVALUABLE MODEL FOR TESTING A DRUG’S ABILITY TO ATTENUATE STRESS-INDUCED REINSTATEMENT OF ALCOHOL-SEEKING BE- HAVIOR IN BOTH MALE AND FEMALE RODENTS. (2) DEMONSTRATE FAVORABLE PHARMACOKINETICS AND A LACK OF CARDIOTOXICITY AND DRUG-DRUG INTERACTIONS (DDIS) FOR KB128. KB128 WILL BE TESTED IN A VARIETY OF ADMET STUDIES IN AT LEAST 5 SPECIES, INCLUDING PLASMA STABILITY AND PLASMA PROTEIN BINDING FOR ALL SPECIES TESTED. AN IN VITRO CARDIOMYOCYTE ASSAY WILL BE CONDUCTED TO MEASURE CHANGES IN INTRACELLULAR CA++ TRANSIENTS; SUCCESS WILL BE DEFINED BY <15% CHANGE IN MEAN PEAK RATE, PEAK SPACING, AND CALCIUM TRANSIENT DURATION. CYP450 INDUCTION, CYP450 REACTION PHENOTYPING AND CYP450 TIME-DEPENDENT AND DIRECT/REVERSIBLE INHIBITION ASSAYS WILL BE CONDUCTED TO CONFIRM THAT KB128 DOES NOT EXHIBIT POTENTIAL CYTOTOXICITY AND NEGATIVE DDIS. OUR RESEARCH TEAM COMBINES EXPERTISE IN SMALL MOLECULE DRUG DEVELOPMENT, IN VIVO PHARMACOLOGY, PRECLINICAL BIOLOGICAL TESTING IN RODENT AUD MODELS, PATENT PROCUREMENT, AND COMMERCIALIZATION.

REAP RENEWABLE ENERGY SYSTEM (RES) GRANT UNRESTRICTED AMOUNT

ARP ECONOMIC DEVELOPMENT GRANT FOR RURAL HEALTH CARE FACILITIES

ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING, AND MISCELLANEOUS GRANTS

WASTE DISPOSAL GRANTS - REGULAR

CONGR HSG SVCS GRNTS

NUEVO LEÓN TRANSPARENCY PUBLIC OUTREACH CAMPAIGN¿ (¿QUIERO CONFIAR EN MÉXICO)

LEONARDO ACADEMY, INC. IS COORDINATING EFFORTS FOR CLEAN DIESEL PROJECTS INVOLVING CLASS 8 DELIVERY TRUCK FLEETS IN LOUISIANA, TEXAS AND MISSOURI. T

DOMESTIC WATER GRANTS - REGULAR

MENTORING PROGRAM GRANTS

LEONARDO ACADEMY WILL ADMINISTER A GRANT PROGRAM THROUGH A REGIONAL COLLABORATION THAT WILL PROVIDE FUNDING FOR CLEAN DIESEL PROJECTS INVOLVING HEAVY

ADVANCED NURSING EDUCATION - SEXUAL ASSAULT NURSE EXAMINERS PROGRAM

THE GOAL OF THE NALEO EDUCATIONAL FUND'S BUILDING HEALTHY COMMUNITIES INITIATIVE IS TO PROVIDE TECHNICAL ASSISTANCE AND CAPACITY BUILDING TO LATINO P

UPWARD BOUND GRANT

DESCRIPTION:- THE AGREEMENT PROVIDES FUNDING TO LEONARDO ACADEMY INC. LEONARDO ACADEMY INC. WILL BE PARTNERING WITH INDEPENDENCE SCHOOL DISTRICT, AND UNDER THE DIRECTION OF LEO, INDEPENDENCE SCHOOL DISTRICT WILL BE RESPONSIBLE FOR OBTAINING QUOTES FROM VENDORS, PLACING THE PURCHASE ORDER, AND PAYING FOR THE EQUIPMENT USING THEIR OWN FUNDING. -SPECIFICALLY, THE RECIPIENT WILL REPLACE 23 DIESEL SCHOOL BUSES WITH 16 LP POWERED SCHOOL BUSES THAT WILL NOTICEABLY REDUCE EMISSIONS FOR ONE OF THE LARGEST EMPLOYERS IN THE COMMUNITY AND THE BUSES WILL REDUCE EMISSIONS BY USING LOW OR NO EMISSIONS TECHNOLOGY, BUT IT ALSO SUPPORTS THE CONTINUATION OF REDUCING EMISSIONS BY AFFORDING INDEPENDENCE SCHOOL DISTRICT WITH THE APPROPRIATE TIME IT NEEDS TO EVALUATE OTHER EMISSION REDUCTION FLEET OPTIONS THAT WORKS FOR ITS CLIMATE. ACTIVITIES:THE ACTIVITIES INCLUDE: - REPLACING 23 DIESEL SCHOOL BUSES WITH 16 LP POWERED SCHOOL BUSES - THE REPLACEMENT OF THESE DIESEL BUSES SUPPORTS THE CONTINUATION OF REDUCING EMISSIONS BY AFFORDING INDEPENDENCE SCHOOL DISTRICT WITH THE APPROPRIATE TIME IT NEEDS TO EVALUATE OTHER EMISSION REDUCTION FLEET OPTIONS THAT WORKS FOR ITS CLIMATE. - UNDER THE DIRECTION OF LEO, INDEPENDENCE SCHOOL DISTRICT WILL BE RESPONSIBLE FOR OBTAINING VENDOR QUOTES AND PERFORMANCE DOCUMENTATION, ISSUANCE OF PURCHASE ORDER, EXPECTED DELIVERY OF THE NEW VEHICLES, PLANNING WITH LEO REGARDING DESTRUCTION AND SCRAPPAGE OF OLD VEHICLES, AND REQUESTING OF TIMING FOR REIMBURSEMENT -REDUCING EMISSIONS FROM REPLACEMENT BY: - .026 ANNUAL REDUCTION = TONS PM2.5 - .085 LIFETIME REDUCTION = TONS PM2.5 - .898 ANNUAL REDUCTION = TONS NOX - 3.210 LIFETIME REDUCTION = TONS NOX - $1,085234 /TON LIFETIME CAPITAL COST EFFECTIVENESSSUBRECIPIENT:NO SUBAWARDS ARE INCLUDED IN THIS ASSISTANCE AGREEMENT.OUTCOMES:THE ANTICIPATED DELIVERABLES INCLUDE: - REPLACING 23 DIESEL SCHOOL BUSES WITH 16 LP POWERED SCHOOL BUSES. - OBTAINING VENDOR QUOTES AND PERFORMANCE DOCUMENTATION, - ISSUANCE OF PURCHASE ORDER, EXPECTED DELIVERY OF THE NEW VEHICLES, - PLANNING WITH LEO REGARDING DESTRUCTION AND SCRAPPAGE OF OLD VEHICLES, AND - REQUESTING OF TIMING FOR REIMBURSEMENT. THE EXPECTED OUTCOMES INCLUDE, - OBTAINING 16 NEW LP POWERED SCHOOL BUSES, - DESTROYING/SCRAPPING 23 DIESEL SCHOOL BUSES, - AND, REDUCING EMISSIONS FROM REPLACEMENT BY: - .026 ANNUAL REDUCTION = TONS PM2.5 - .085 LIFETIME REDUCTION = TONS PM2.5 - .898 ANNUAL REDUCTION = TONS NOX - 3.210 LIFETIME REDUCTION = TONS NOX - $1,085234 /TON LIFETIME CAPITAL COST EFFECTIVENESS THE INTENDED BENEFICIARIES INCLUDE, LEONARDO ACADEMY INC. AND THEY ARE PARTNERING WITH INDEPENDENCE SCHOOL DISTRICT.

KANI K?PINA?I: ECONOMIC EQUITY FOR CULTURAL PRACTITIONERS - KANI KŪPINAʻI: ECONOMIC EQUITY FOR CULTURAL PRACTITIONERS

KANI K? I LOHE ?IA: LINGUISTIC GENEALOGY IN MELE - KANI KO I LOHE ¿IA: LINGUISTIC GENEALOGY IN MELE

CONFLICT MANAGEMENT AND MITIGATION AWARD - BUILDING SHARED COMMUNITIES PROGRAM

THIS PROJECT WILL IMPROVE AIR QUALITY IN THE STATES OF ILLINOIS AND WISCONSIN BY REDUCING EMISSIONS FROM INUSE DIESEL ENGINES. THIS PROJECT WILL ACH

NA MEHEU O NA KUPUNA (THE NATIVE BEHAVIORS & BELEIFS OF OUR ANCESTORS)- THIS PROJECT WILL ADDRESS THE STRENGTHENING OF HAWAIIAN LANGUAGE PROFICIENCIE

A PORT CARBON MONITORING SYSTEM: EVALUATING GHG REDUCTIONS FROM ELECTRIFICATION AND GREEN SHIPPING CORRIDORS

LEONARDO ACADEMY INC. WILL BE COORDINATING EFFORTS TO ADMINISTER A REGIONAL GRANT PROGRAM THAT WILL PROVIDE FUNDING FOR CLEAN DIESEL PROJECTS INVOLVI

VALIDATION OF MEASURES OF RESTLESS LEGS SYNDROME FOR ELDERS WITH MEMORY DISORDERS

ASSISTANCE TO FIREFIGHTERS GRANT

CHP

TAS::89 0331::TAS RECOVERY NEW AWARD ENTITLED "RECOVERY ACT: DEMONSTRATION WITH ENERGY AND DAYLIGHTING ASSESSMENT OF SUNLIGHT RESPONSIVE THERMOCHROM

TEACHER DEVELOPMENT PROJECT

DRS TECHNOLOGIES TAKES PLEASURE IN PRESENTING THIS MULTI-BAND UNCOOLED RADIOMETER IMAGER (MURI) PROPOSAL FOR THE INSTRUMENT INCUBATOR PROGRAM (IIP) THAT WILL PROVIDE IMPROVED RADIOMETRIC IMAGING PERFORMANCE SUBSTANTIALLY REDUCE THE COST COMPLEXITY AND DEVELOPMENT TIME FOR FUTURE POLAR ORBITING EARTH OBSERVATION IMAGING RADIOMETER SENSORS. OUR PROPOSED SOLUTION LEVERAGES CONVENTIONAL LOW COST UNCOOLED MICROBOLOMETERS WITH A COMPACT PIEZO DRIVEN BACKSCAN AND OUR PATENTED TCOMP ALGORITHMS FOR IMPROVED RADIOMETRIC ACCURACY AND STABILITY. OUR SOLUTION ELIMINATES THE NEED FOR CRYOGENIC COOLING SOLVES THE PROBLEM OF IMAGE SMEAR ASSOCIATED WITH THE BOLOMETERS RELATIVELY LONG TIME CONSTANT WHILE SIMULTANEOUSLY ENSURING LOW NEDT. THE OBJECTIVE OF THE DRS PROPOSED MURI PROGRAM IS TO DEMONSTRATE THAT MODERN LOW COST LARGE AREA MICROBOLOMETER FPAS CAN BE UTILIZED TO PROVIDE NARROW BAND RADIOMETRICALLY ACCURATE IMAGING IN 8 LWIR BANDS FOR EARTH SCIENCE APPLICATIONS. THE POTENTIAL EARTH SCIENCE APPLICATIONS FOR THIS TECHNOLOGY ARE LAND SURFACE CLIMATOLOGY MEASUREMENT OF SOIL MOISTURE CONTENT MEASUREMENT OF ECOSYSTEM DYNAMICS VOLCANO MONITORING HAZARD MONITORING GEOLOGY AND SOILS. ON THE IIP PROGRAM DRS PLANS TO DESIGN BUILD TEST AND DEMONSTRATE AN UNCOOLED MICROBOLOMETER BREADBOARD SENSOR HARDWARE FOR EARTH OBSERVATION. OUR SCIENCE PARTNER ROCHESTER INSTITUTE OF TECHNOLOGY (RIT) WILL SUPPORT THE AIRBORNE DATA COLLECTS RADIOMETRIC DATA ANALYSIS AND COMPARISON TO LANDSAT 8 FOR A TRUTH REFERENCE AND THE SCIENCE IMPLEMENTATION ASPECT OF THE INSTRUMENT DATA COLLECTS. DRS/RIT WILL COLLECT AIRBORNE DATA FOR THREE PRIMARY APPLICATIONS IN 8 SPECTRAL BANDS. THE FIRST WILL ASSESS INITIAL DATA QUALITY AND CALIBRATION WITH KNOWN TARGETS DEPLOYED THE SECOND WILL DEMONSTRATE SCIENTIFIC PRODUCTS AVAILABLE OVER VEGETATIVE AND URBAN ENVIRONMENTS WHILE THE THIRD WILL DEMONSTRATE IMPORTANT ASPECTS OF VOLCANO MONITORING. ONE KEY TECHNOLOGICAL SOLUTION IS THE USE OF A PIEZO BACK-SCAN STAGE LOCATED AT THE IMAGE PLANE. THE PIEZO DRIVE VELOCITY WILL BE SET TO MATCH THE AIRCRAFT GROUND VELOCITY DURING IMAGE COLLECTION SUCH THAT THE IMAGE SMEAR FROM THE BOLOMETER S LONG TIME CONSTANT IS ELIMINATED. THIS IS CRITICAL FOR THE USE OF A STANDARD MICROBOLOMETER ARRAY WHICH TYPICALLY HAS ~14MSEC TIME CONSTANT. ANOTHER KEY FEATURE IS THE REAL-TIME RADIOMETRIC CORRECTION THAT WILL OCCUR DURING FLIGHT TO ACCOUNT FOR THE INSTRUMENT AND OPTICS TEMPERATURE CHANGES DURING OPERATION. THIS METHODOLOGY IS BEING UTILIZED BY DRS IN COMMERCIAL RADIOMETERS AND WILL BE IMPLEMENTED HERE TO ACCOUNT FOR INSTRUMENT/OPTICS TEMPERATURE CHANGES AND THEIR CONTRIBUTION TO RADIOMETRIC ERROR. THIS IS A DRAMATIC SHIFT FROM PRIOR RADIOMETERS BUILT FOR EARTH OBSERVATION IN THAT THOSE INSTRUMENTS TYPICALLY COOL THE OPTICS TO REDUCE RADIOMETRIC ERROR. WE ENVISION A SPACE INSTRUMENT USING 10 FPAS WITH UP TO 12 SPECTRAL FILTERS TO COVER A GROUND SWATH WIDTH OF 310KM FROM A 705KM ALTITUDE ORBIT AND A 100M GSD. FOR THIS AIRBORNE DEMO WE PLAN TO UTILIZE 4 FPAS WITH 8 SPECTRAL BAND FILTERS TO DEMONSTRATE THE KEY TECHNOLOGY WITHIN THE MORE LIMITED IIP PROGRAM BUDGET. FOR AN AIRBORNE DEMO USING 120MM EFL F/1 OPTICS AT 15 000FT ALTITUDE WILL HAVE A 0.65M GSD WITH TWO PARALLEL SWATH WIDTHS OF 414KM SEPARATED BY A GAP OF 619M. WE WILL SHOW DIRECT APPLICABILITY TO A SPACE INSTRUMENT AND HOW IT IS EASILY SCALABLE USING A STAGGER BUTTED ARRAY APPROACH. MUCH OF THE SAME HARDWARE COULD BE UTILIZED ON A SPACE VERSION OF THIS INSTRUMENT. PERIOD OF PERFORMANCE OF THIS IIP PROJECT IS EXPECTED TO BE 36 MONTHS. THE FIRST YEAR OF THE PROGRAM WILL INVOLVE THE DESIGN OF THE INSTRUMENT HARDWARE THE SECOND YEAR WILL BE THE BUILD OF THE COMPONENTS INTEGRATION AND ASSEMBLY OF THE INSTRUMENT AND THE THIRD YEAR WILL BE LABORATORY TEST OF THE INSTRUMENT AND AIRBORNE FIELD TESTING. ENTRY LEVEL TRL FOR THIS INSTRUMENT IS 3; EXIT LEVEL TRL AT THE END OF YEAR 3 WILL BE 6.

THE ARCTIC IS A REGION EXPERIENCING CLIMATE CHANGE AT THE SAME RATE AS THE REST OF THE PLANET, BUT WITH IMPACTS ON SEASONAL AIR TEMPERATURES, OCEAN I

DOMESTIC WATER GRANTS - REGULAR

COMMUNITY DEVELOPMENT BLOCK GRANTS/ENTITLEMENT GRANTS

PURPOSE: ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING/CONGRESSIONAL DIRECTED SPENDING AWARDS ARE AUTHORIZED UNDER THE CONSOLIDATED APPROPRIATIONS ACT, 2022 PUBLIC LAW 117-328 AND THE EXPLANATORY STATEMENT FOR DIVISION L OF THAT ACT. PROJECTS SELECTED FOR COMMUNITY PROJECT FUNDING/CONGRESSIONAL DIRECTED SPENDING ARE LISTED IN THE JOINT EXPLANATORY STATEMENT (JES) THAT ACCOMPANIES A SPECIFIC FISCAL YEAR’S APPROPRIATIONS ACT OR CONGRESSIONAL RECORD. THE JES LISTS PROJECT, RECIPIENT, STATE, AMOUNT AND CONGRESSIONAL SPONSOR.; ACTIVITIES TO BE PERFORMED: ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING AWARD PROJECTS INCLUDE A WIDE VARIETY OF ACTIVITIES THAT RESULT IN ECONOMIC DEVELOPMENT OR COMMUNITY DEVELOPMENT OUTCOMES. HUD WILL NOT KNOW THE FULL SCOPE OF THE PROJECT UNTIL THE RECIPIENT SUBMITS THE REQUIRED PROJECT NARRATIVE AND CONFIRMS ALIGNMENT WITH THE LANGUAGE AS PROVIDED IN THE CONGRESSIONAL RECORD. TO FIND THE DETAILS OF THE GRANT AWARD AS WRITTEN WITHIN THE CONGRESSIONAL RECORD USE THE FOLLOWING LINK AND PATH SELECTIONS TO GET TO THE DESCRIPTION OF THE ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING GRANTS HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/EDI-GRANTS, SELECT THE FISCAL YEAR OF INTEREST, SCROLL DOWN TO PROGRAM LAWS AND REGULATIONS, UNDER FISCAL YEAR 20XX CONSOLIDATED APPROPRIATIONS ACT, 20XX: CONGRESSIONAL RECORD (JOINT EXPLANATORY STATEMENT).; EXPECTED OUTCOMES: COMPLETION OF THE PROJECT AS DESCRIBED IN THE JOINT EXPLANATORY STATEMENT (JES) PROJECT DESCRIPTION AND SUBSEQUENT APPROVED PROJECT NARRATIVE.; INTENDED BENEFICIARIES: THE PROJECT BENEFICIARIES ARE THE INDIVIDUALS AND/OR ORGANIZATIONS THAT ARE AWARDED GRANT FUNDS OR SERVED BY THE ENTITIES THAT ARE AWARDED GRANT FUNDS AS IDENTIFIED IN THE JES RECIPIENT OR PROJECT DESCRIPTION SECTIONS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

RURAL RESIDENCY PLANNING AND DEVELOPMENT PROGRAM

DESCRIPTION:THIS AGREEMENT PROVIDES FUNDING TO CITY OF NAPOLEON TO IMPLEMENT ITS PROJECT TO REPLACE SERVICE LINES AS DIRECTED IN THE 2024 CONSOLIDATED APPROPRIATIONS ACT OR AS IDENTIFIED IN AN APPROVED TECHNICAL CORRECTION IF ONE HAS BEEN APPROVED FOR THIS PROJECT.ACTIVITIES:THE ACTIVITIES INCLUDE REPLACEMENT OF THE EXISTING CAST IRON AND ASBESTOS CEMENT WATERLINE ON OAKWOOD AVENUE FROM NORTH PERRY STREET TO VANHYNING CREEK IN NAPOLEON, OH. THE WATER MAIN, SERVICES, AND APPURTENANCES WILL BE REPLACED WITH PVC WATER MAINS AND COPPER WATER SERVICE LINES. APPROPRIATE VALVES AND HYDRANTS WILL ALSO BE INSTALLED TO PROVIDE BETTER SERVICE AND FIRE PROTECTION. SUBRECIPIENT:NO SUBAWARDS ARE INCLUDED IN THIS ASSISTANCE AGREEMENT.OUTCOMES:THE ANTICIPATED DELIVERABLES INCLUDE NEW PVC WATER MAINS AND COPPER WATER SERVICE LINES. THE EXPECTED OUTCOMES INCLUDE A MORE SECURE DRINKING WATER SOURCE AS THE OLD WATERMAINS AND SERVICE LINES ARE OLD. THE INTENDED BENEFICIARIES INCLUDE THE RESIDENTS OF THE CITY OF NAPOLEON, OH.

THIS EDA INVESTMENT FUNDS THE NORTH FLORIDA INNOVATION LABS TECHNOLOGY ACCELERATOR LAUNCH PROJECT, TO PROVIDE PROGRAMMATIC AND OPERATIONAL SUPPORT FOR THE LAUNCH OF THE NORTH FLORIDA INNOVATION LABS TECHNOLOGY ACCELERATOR. THE PROJECT WILL COMBINE A TECHNOLOGY-FOCUSED FACILITY WITH STAFF AND ENTREPRENEUR SUPPORT RESOURCES TO ACCELERATE THE DEVELOPMENT OF INNOVATIVE TECHNOLOGY-FOCUSED BUSINESSES. ONCE IMPLEMENTED, THE PROJECT WILL HELP MOVE THE AREA TOWARD TECHNOLOGY-BASED INNOVATION AND CREATE EMPLOYERS FOCUSED ON TECHNOLOGY-BASED PRODUCTS.

WASTE DISPOSAL GRANTS - REGULAR

SBIR PHASE II: A VALUE-BASED APPROACH FOR QUANTIFYING PROBLEM SOLVING STRATEGIES

WASTE DISPOSAL GRANTS - 09/10 MULTI-YEAR STIMULUS

LEONARDO ACADEMY INC. WILL ADMINISTER A TWO-PHASE GRANT PROGRAM THROUGH A REGIONAL COLLABORATION THAT WILL PROVIDE FUNDING FOR CLEAN DIESEL PROJECTS

FINANCIAL ASSISTANCE AWARD

EMERGING MATHEMATICS AND COMPUTER SCIENCE SCHOLARS (EMACS)

MELE: INDIGENOUS METHODOLOGY FOR STEM AND LANGUAGE EDUCATION

MEEKER MCLEOD PREVENTION COALITION

DOMESTIC WATER GRANTS - REGULAR

THIS AGREEMENT WILL PROVIDE ASSISTANCE TO LEONARDO ACADEMY INCORPORATED (LEONARDO ACADEMY) IN ITS EFFORTS TO REDUCE DIESEL EMISSIONS AND EXPOSURE IN THE COUNTY OF CUYAHOGA, OHIO. THROUGH THE EARLY REPLACEMENT OF 4 DIESEL TERMINAL TRACTOR WITH 4 100 PERCENT&NBSPANDELECTRIC TERMINAL TRACTOR, LEONARDO ACADEMY WILL REDUCE EMISSIONS OF DIESEL PARTICULATE MATTER AND OTHER POLLUTANTS SUCH AS NITROGEN OXIDES, CARBON MONOXIDE AND HYDROCARBONS.THIS PROJECT WILL BENEFIT THE PUBLIC AND IN PARTICULAR, THOSE WHO LIVE, WORK OR PLAY NEAR WHERE THE AFFECTED FLEET OPERATES.&NBSPAND THIS ASSISTANCE AGREEMENT SHOULD BENEFIT THE PUBLIC WITH CLEANER AIR AND LOWER TOXIC EMISSIONS OF DIESEL EXHAUST.

REAP RENEWABLE ENERGY SYSTEM (RES) GRANT UNRESTRICTED AMOUNT

THIS ASSISTANCE AGREEMENT WILL IMPROVE AIR QUALITY IN THE MADISON WISCONSIN REGION 5 AREA BY REDUCING EMISSIONS FROM IN-USE DIESEL ENGINES. THIS P

LEONARDO ACADEMY WILL ADMINISTER A GRANT PROGRAM THAT WILL PROVIDE FUNDING FOR CLEAN-DIESEL PROJECTS INVOLVING LONG-HAUL AND SHORT-HAUL TRUCKS, SCHOO

WASTE DISPOSAL GRANTS - 09/10 STIMULUS

THIS PROJECT WILL IMPROVE AIR QUALITY IN THE GREEN BAY AND KENOSHA AREAS OF WISCONSIN BY REDUCING DIESEL EMISSIONS FROM 17 TRANSIT BUSES. THIS PROJE

PURPOSE: CONSTRUCT/EXPAND HANGAR. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT CONSTRUCTS A NEW 9,400 SQUARE FOOT SPONSOR-OWNED HANGAR FOR AIRCRAFT STORAGE TO ASSIST THE AIRPORT TO BE AS SELF-SUSTAINING AS POSSIBLE BY GENERATING REVENUE. THE SPONSOR HAS ADEQUATELY FINANCED THE AIRSIDE NEEDS OF THE AIRPORT. THIS GRANT FUNDS A PORTION OF THE FINAL PHASE, WHICH CONSISTS OF CONSTRUCTION. . THIS PROJECT IS ASSOCIATED WITH AN INFRASTRUCTURE INVESTMENT AND JOBS ACT GRANT THAT FUNDS THE REMAINING ELIGIBLE PORTION OF THE PROJECT. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH LEOTI, KANSAS.

ENTITLED CITIES

ON-LINE ERGONOMICS SOLUTIONS

ENTITLED CITIES

ENTITLED CITIES

AMERICAN RESCUE PLAN

2019 HPF SAT - LEONA TATE FOUNDATION FOR CHANGE

2019 HPF AACR - LEONA TATE FOUNDATION FOR CHANGE

2016 HPF AACR - LEONA TATE FOUNDATION FOR CHANGE

SEC. 9007 REAP-ENERGY EFFICIENCY IMPROVEMENTS GRANTS (MAN)

CAPITAL AREA REAL TIME CRIME CENTER OPERATIONAL AND RESEARCH PARTNERSHIP.

THIS PROPOSAL IS AN ESA/NASA COLLABORATION TO FLY THE MAMAP SENSOR ON THE NAVY CIRPAS TWIN OTTER IN SUPPORT OF THE HYSPIRI CAMPAIGN. OUR STUDY GOAL I

REORGANIZATION AND COMPUTERIZATION OF THE NON-TYPE SYSTEMATIC MOLLUSK COLLECTION OF THE PALEONTOLOGICAL RESEARCH INSTITUTION

IMPLEMENT VARIED CONTROL STRATEGIES AND INVOLVEMENT OF NATIONAL, STATE AND LOCAL PARTNERS TO REDUCE POLLUTION EMITTED FROM DIESEL ENGINES.

PROJECT CONNECT WILL ALLOW THE COUNTY DETENTION FACILITY TO PLAN, IMPLEMENT AND EXPAND EFFECTIVE REENTRY PROGRAMMING ENCOMPASSING PRE- AND POST-RELEASE EFFORTS TO REDUCE RECIDIVISM BY PROVIDING EVIDENCE-BASED SERVICES THAT IMPROVE EMPLOYMENT, HOUSING, AND TRANSPORTATION SUCCESS FOR INDIVIDUALS REENTERING THE COMMUNITY FOLLOWING INCARCERATION. PROJECT CONNECT WILL ENHANCE AND EXPAND THE PARTNERSHIP BETWEEN THE LOCAL SHERIFFS OFFICE AND SEVERAL REENTRY-FOCUSED COMMUNITY-BASED PARTNERS, STRENGTHENING REENTRY EFFORTS IN THE COMMUNITY. PROJECT CONNECT IS AN INNOVATIVE PROJECT TO CONNECT INCARCERATED PERSONS TO COMMUNITY-BASED RESOURCES (PRE- AND POST-RELEASE) FOCUSED ON EMPLOYMENT/EDUCATION, HOUSING, AND TRANSPORTATION, LEADING TO IMPROVED REENTRY EXPERIENCES. WE EXPECT LOWER RECIDIVISM NUMBERS AND MORE SIGNIFICANT COMMUNITY CONNECTEDNESS, MAKING THE REENTRY EXPERIENCE SUCCESSFUL AND PRODUCTIVE. THE INTENDED OUTCOME IS MORE EMPLOYMENT OPPORTUNITIES, ACCESS TO SAFE AND AFFORDABLE HOUSING, AND THE ABILITY TO TRAVEL THROUGHOUT THE COMMUNITY. THE FOCUS AREA IS A MID-SIZED COUNTY WITH A DETENTION FACILITY HOUSING UP TO 1100 INDIVIDUALS. BENEFICIARIES WILL BE THOSE AFFECTED BY INCARCERATION, INCLUDING CURRENT AND FORMER INMATES, THEIR FAMILIES, AND THE GREATER COMMUNITY. THROUGH COLLECTING AND INTENTIONAL PARTNERSHIPS WITH STRONG COMMUNITY PARTNERS, WE AIM TO REDUCE OUR OVERALL JAIL POPULATION WHILE IMPROVING THE DELIVERY OF SERVICES PRE-AND POST-RELEASE. PROJECT CONNECT WILL ENGAGE PARTICIPANTS IN CUSTODY AT THE DETENTION FACILITY AND CONTINUE PROVIDING SERVICES FOR UP TO 12 MONTHS POST-RELEASE. PROJECT CONNECT WILL ASSIST DEDICATED PROGRAM STAFF IN DEVELOPING INDIVIDUAL CASE PLANS BASED ON EVIDENCE-BASED CRIMINOGENIC NEEDS ASSESSMENTS DELIVERED THROUGH AN ESTABLISHED AND PROVEN ASSESSMENT TOOL DEVELOPED AND SUPPORTED BY THE STATE DEPARTMENT OF CORRECTIONS. THESE CASE PLANS WILL FOCUS ON EVIDENCE-BASED INTERVENTIONS BEFORE RELEASE TO SUPPORT PARTICIPATION IN ESTABLISHED AND EMERGING PROGRAMMING WITH OUR DETENTION FACILITY. UPON RELEASE, THE CASE PLAN WILL PROVIDE PARTICIPANTS WITH A PERSONAL REENTRY PLAN TO GUIDE THEM AS THEY RETURN TO THE COMMUNITY. WE ARE IN THE MOST ECONOMICALLY DISTRESSED COMMUNITY IN OUR STATE, DISPROPORTIONATELY IMPACTING COMMUNITIES OF COLOR, PARTICULARLY YOUNG AFRICAN AMERICAN MALES. THE RACIAL BREAKDOWN OF OUR JAIL POPULATION, AND AS A RESULT, OUR REENTRY POPULATION, AFFECTS THESE COMMUNITIES THE GREATEST. AS A RESULT, THE LOCAL SHERIFF AND HIS ENTIRE STAFF HAVE COMMITTED TO INNOVATIVE THINKING AND PLANNING TO TARGET THOSE COMMUNITY DEFICIENCIES AND MAKE A MEANINGFUL DIFFERENCE IN EFFECTING LASTING CHANGE. EFFORTS TO SIGNIFICANTLY IMPACT THESE COMMUNITIES HAVE FALLEN SHORT AND REQUIRE A MORE COLLABORATIVE APPROACH TO ENSURE IMPACTFUL AND LASTING CHANGE. PROJECT CONNECT WILL SUPPORT SIGNIFICANT LIFE-CHANGE FOR INCARCERATED INDIVIDUALS, THEIR FAMILIES, AND THE GREATER COMMUNITY.

HYPERSPECTRAL IMAGING SPECTROSCOPIC INVESTIGATION OF CALIFORNIA NATURAL AND ANTHROPOGENIC FOSSIL METHANE EMISSIONS IN THE SHORT-WAVE AND THERMAL INFRARED. ON A 20-YEAR TIMESCALE CH4 HAS A LARGER GREENHOUSE EFFECT THAN CO2 AND ITS DECADAL LIFETIME MAKES IT MORE AMENABLE TO REGULATORY APPROACHES. YET SOURCES REMAIN POORLY QUANTIFIED. TOP-DOWN AND BOTTOM-UP REGIONAL AND GLOBAL CH4 BUDGETS OFTEN DISAGREE SIGNIFICANTLY EG HSU ET AL (2009) FOUND AN ~40% DISCREPANCY FOR THE LA BASIN. MUCH OF THE DISCREPANCY COULD RELATE TO FOSSIL CH4 FROM FUGITIVE INDUSTRIAL (FFI) AND GEOLOGIC SOURCES; A RECENT LA BASIN SURVEY (NOAA) SUGGESTS FFI. SOME STUDIES SUGGEST RECENT CH4STABILIZATION WAS FROM GLOBAL FFI CH4 EMISSION DECREASES. RECENT TRANSCONTINENTAL GROUND CH4 DATA VALIDATED SCIAMACHY&GOSAT DATA WITH SIMILAR CONCLUSIONS. OTHERS SUGGEST AN ~50% US FFI UNDERESTIMATE. THE PLANNED AVIRIS/MASTER FLIGHTS COVER SIGNIFICANT FFI INDUSTRIAL ACTIVITY AND GEOLOGIC CH4 EMISSION SITES. THE KEY STUDY SCIENCE QUESTION IS: WHAT ARE THE RELATIVE CALIFORNIA CONTRIBUTIONS OF FOSSIL GEOLOGIC AND FFI CH4? I.E. ADDRESSING THE RELATIONSHIP BETWEEN FOSSIL CH4 EMISSIONS AND GEOLOGIC MARINE AND ATMOSPHERIC (EG INVERSION LAYERS BUOYANT RISE) CONTROLS. THIS PRIMARILY IS AN APPLICATION STUDY USING AVIRIS (EG HYSPIRI VSWIR) AND MASTER (EG HYSPIRI TIR) AND TO A LESSER EXTENT A RESEARCH STUDY. IT DIRECTLY ADDRESSES THE RFP BY: 1) DEMONSTRATING SCIENCE APPLICATIONS (CH4 EMISSION) ENABLED BY HYSPIRI-LIKE SENSORS AND AIDS HYSPIRI MISSION DESIGN (BAND SELECTION AND BINNING ALGORITHMS); 2) PROVIDING UNPRECEDENTED INFORMATION FOR RESOURCE MANAGEMENT TO RESOURCE MANAGERS THOUGH MERGING AVIRIS DATA WITH EXISTING DATA. THE STUDY FITS HYSPIRI MISSION GOALS THROUGH ADDRESSING SCIENCE DEFINITION TEAM QUESTIONS: CQ5 (TERRESTRIAL SURFACE COMPOSITION) TQ4 (URBANIZATION AND ENVIRONMENT) AND VQ2 (SEASONAL CYCLES OF TERRESTRIAL ECOSYSTEM AND LAND DISTURBANCE AND CLIMATECHANGE). OUR TEAM COMPRISES SCIENTISTS AND RESOURCE MANAGERS WITH SPECIFIC EXPERTISE TO ASSURE PROJECT SUCCESS. WE WILL STUDY FACTORS AFFECTING TRACE GAS (CH4 CO2) SWIR RETRIEVALS IN AVIRIS SWIR DATA FOR FOSSIL SOURCES TO CHARACTERIZE THE EFFECT OF ALBEDO NADIR ANGLE AEROSOLS WATER VAPOR PATH RADIANCE VERTICAL PROFILES SURFACE SPECTRAL NON-UNIFORMITY PIXEL SIZE SPECTRAL RESOLUTION AND SPECTRAL SPACING. SWIR-DERIVED CH4 WILL BE COMPARED WITH MASTER TIR SPECTRAL CH4 ANOMALIES. RETRIEVAL APPROACHES INCLUDING NEIGHBORING PIXEL NORMALIZATION BAND RATIO RESIDUAL MINIMIZATION AND STATISTICAL MEASURES BASED ON RADIATIVE TRANSFER CALCULATIONS FOR SWIR AND TIR ABSORPTION FEATURES WILL BE INVESTIGATED. IMPROVED SWIR TRACE GAS RETRIEVALS USING TIR-DERIVED VERTICAL PROFILESWILL BE STUDIED. MOBIL GROUND-REFERENCE CH4 MEASUREMENTS INCLUDING EDDY COVARIANCE FLUXES AND ALKANE GAS CHROMATOGRAPHY OF C2-C8 WILL PROVIDE RELEVANT SIZE SCALES AND NATURAL GAS FINGERPRINTING. WE WILL IDENTIFY THE BEST REMOTE SENSING AND IN SITU PLUME CHARACTERIZATION APPROACHES RELEVANT CH4 SIZE SCALES AND MERGING OF MOBILE IN SITU DATA WITH AIRBORNE AND SATELLITE REMOTE SENSINGTO IMPROVE FLUX ESTIMATION AND SOURCE ATTRIBUTION. REGIONAL SCALING IS BY COMPARISON WITH SCIAMACHY/GOSAT DATA AND MAPS OF FFI ACTIVITY AND GEOLOGIC STRUCTURES. WE LEVERAGE PLANNED 2013/2014 CARVE (JPL) FTIR SPECTROMETER CALIFORNIA TRANSIT FLIGHTS AND MAKO (AEROSPACE CORP.) HIGH-SPECTRAL RESOLUTION TIR AIRBORNE FLIGHTS AND DISCOVER (AQ) AIRBORNE DATA AT NO COST TO THE STUDY. MAKO TIR DATA WILL ENABLE ALLOW EVALUATION OF MASTER TIR SPECTRAL RESPONSE CHARACTERISTICS. THE STUDY FOCUSES ON THE COAL OIL POINT (COP) SEEP FIELD (NATURAL GEOLOGIC) THE ELK HILLS AND KERN OIL FIELDS (ANTHROPOGENIC) LA BREA SEEPAGE AND A RANGE OFURBAN CITES. PRIOR SEBASS DATA FROM THESE SITES AND AVIRIS/MASTER COP DATA ARE AVAILABLE AND SURFACE CH4 DATA WERE COLLECTED FEB. 2012 FOR THIS PROPOSAL. SEVERAL STUDIES HAVE DEMONSTRATED SUCCESSFUL AVIRIS COP CH4 RETRIEVAL. LA BRE

PURPOSE: THE COMMUNITY DEVELOPMENT BLOCK GRANT (CDBG) PROGRAM PROVIDES ANNUAL GRANTS ON A FORMULA BASIS TO STATES, CITIES, AND COUNTIES TO DEVELOP VIABLE URBAN COMMUNITIES BY PROVIDING DECENT HOUSING AND A SUITABLE LIVING ENVIRONMENT, AND BY EXPANDING ECONOMIC OPPORTUNITIES, PRINCIPALLY FOR LOW- AND MODERATE-INCOME PERSONS. THE PROGRAM IS AUTHORIZED UNDER TITLE 1 OF THE HOUSING AND COMMUNITY DEVELOPMENT ACT OF 1974, PUBLIC LAW 93-383, AS AMENDED 42 U.S.C. 5301 ET SEQ. THE CDBG PROGRAM COVERS FOUR DISTINCT PROGRAMS, EACH WITH THEIR OWN SET OF GOVERNING REGULATIONS: CDBG ENTITLEMENT, CDBG NON-ENTITLED COUNTIES IN HAWAII, CDBG INSULAR AREAS, AND STATE CDBG. IN THE CDBG ENTITLEMENT PROGRAM, HUD AWARDS GRANTS TO ENTITLEMENT COMMUNITY GRANTEES TO CARRY OUT A WIDE RANGE OF COMMUNITY DEVELOPMENT ACTIVITIES. ENTITLEMENT COMMUNITIES DEVELOP THEIR OWN PROGRAMS AND FUNDING PRIORITIES. IN THE CDBG NON-ENTITLED COUNTIES IN HAWAII PROGRAM, THREE COUNTIES QUALIFY: HAWAII, KAUAI, AND MAUI. THE FY 2004 APPROPRIATIONS ACT REQUIRED THE GOVERNOR OF HAWAII TO DECIDE IF THE STATE WISHED TO PARTICIPATE IN THE STATE CDBG PROGRAM BY JULY 31, 2004. THE STATE MADE THE DECISION NOT TO PARTICIPATE IN THE PROGRAM. AS A RESULT OF THIS DECISION HUD'S HONOLULU FIELD OFFICE ADMINISTERS THE NON-ENTITLED GRANTS IN HAWAII. FUNDS ARE ALLOCATED USING A FORMULA BASED ON POPULATION, POVERTY, AND HOUSING OVERCROWDING, WITH THE POVERTY FACTOR CARRYING A DOUBLE WEIGHT. FOR THE CDBG INSULAR AREAS PROGRAM, HUD ANNUALLY ALLOCATES CDBG GRANTS TO FOUR DESIGNATED AREAS: AMERICAN SAMOA; GUAM; NORTHERN MARIANA ISLANDS; AND THE U.S. VIRGIN ISLANDS. THE FUNDS ARE ALLOCATED IN PROPORTION TO THE POPULATIONS OF THE ELIGIBLE TERRITORIES. THE PROGRAM IS ADMINISTERED BY HUD'S FIELD OFFICES IN PUERTO RICO AND HAWAII. UNDER THE STATE CDBG PROGRAM, STATES PASS THROUGH CDBG GRANTS TO UNITS OF GENERAL LOCAL GOVERNMENT. ANNUALLY, EACH STATE DEVELOPS FUNDING PRIORITIES AND CRITERIA FOR SELECTING PROJECTS. SINCE STATES ARE IN THE BEST POSITION TO KNOW, AND TO RESPOND TO, THE NEEDS OF LOCAL GOVERNMENTS, CONGRESS AMENDED THE HOUSING AND COMMUNITY DEVELOPMENT ACT OF 1974 (HCD ACT) IN 1981 TO GIVE EACH STATE THE OPPORTUNITY TO ADMINISTER CDBG FUNDS FOR NON-ENTITLEMENT AREAS. NON-ENTITLEMENT AREAS INCLUDE THOSE UNITS OF GENERAL LOCAL GOVERNMENT WHICH DO NOT RECEIVE CDBG FUNDS DIRECTLY FROM HUD. GENERALLY, NON-ENTITLEMENT AREAS ARE CITIES WITH POPULATIONS OF LESS THAN 50,000 (EXCEPT CITIES THAT ARE DESIGNATED PRINCIPAL CITIES OF METROPOLITAN STATISTICAL AREAS), AND COUNTIES WITH POPULATIONS OF LESS THAN 200,000. CURRENT CDBG AWARDS AND ALLOCATIONS ARE INCLUDED IN THIS LIST OF HUD COMMUNITY PLANNING AND DEVELOPMENT (CPD) AWARDS AND ALLOCATIONS LOCATED AT: HTTPS://WWW.HUDEXCHANGE.INFO/GRANTEES/ALLOCATIONS-AWARDS/; ACTIVITIES TO BE PERFORMED: CDBG FUNDS MAY BE USED FOR ACTIVITIES WHICH INCLUDE, BUT ARE NOT LIMITED TO: ACQUISITION OF REAL PROPERTY; RELOCATION AND DEMOLITION; REHABILITATION OF RESIDENTIAL AND NON-RESIDENTIAL STRUCTURES; CONSTRUCTION OF PUBLIC FACILITIES AND IMPROVEMENTS, SUCH AS WATER AND SEWER FACILITIES, STREETS, NEIGHBORHOOD CENTERS, AND THE CONVERSION OF SCHOOL BUILDINGS FOR ELIGIBLE PURPOSES; PUBLIC SERVICES, WITHIN CERTAIN LIMITS; ACTIVITIES RELATING TO ENERGY CONSERVATION AND RENEWABLE ENERGY RESOURCES; PROVISION OF ASSISTANCE TO PROFIT-MOTIVATED BUSINESSES TO CARRY OUT ECONOMIC DEVELOPMENT AND JOB CREATION/RETENTION ACTIVITIES. EACH ACTIVITY MUST MEET ONE OF THE FOLLOWING NATIONAL OBJECTIVES FOR THE PROGRAM: BENEFIT LOW- AND MODERATE-INCOME PERSONS, PREVENTION OR ELIMINATION OF SLUMS OR BLIGHT, OR ADDRESS COMMUNITY DEVELOPMENT NEEDS HAVING A PARTICULAR URGENCY BECAUSE EXISTING CONDITIONS POSE A SERIOUS AND IMMEDIATE THREAT TO THE HEALTH OR WELFARE OF THE COMMUNITY FOR WHICH OTHER FUNDING IS NOT AVAILABLE. GENERALLY, THE FOLLOWING TYPES OF ACTIVITIES ARE INELIGIBLE: ACQUISITION, CONSTRUCTION, OR RECONSTRUCTION OF BUILDINGS FOR THE GENERAL CONDUCT OF GOVERNMENT; POLITICAL ACTIVITIES; CERTAIN INCOME PAYMENTS; CONSTRUCTION OF NEW HOUSING (WITH SOME EXCEPTIONS). UNDER THE STATE CDBG PROGRAM, STATES MAY USE $100,000 PLUS UP TO A MAXIMUM OF THREE PERCENT OF ITS CDBG ALLOCATION. AMOUNTS EXPENDED ON ADMINISTRATION IN EXCESS OF $100,000 MUST BE MATCHED. STATES MAY EXPEND UP TO THREE PERCENT OF THEIR CDBG ALLOCATION ON TECHNICAL ASSISTANCE ACTIVITIES. HOWEVER, THE TOTAL A STATE SPENDS ON BOTH ADMINISTRATIVE AND TECHNICAL ASSISTANCE EXPENSES MAY NOT EXCEED $100,000 PLUS THREE PERCENT OF THE STATE'S ALLOCATION. CPD HAS DEVELOPED PROFILES THAT DISPLAY GRANTEE-REPORTED ACCOMPLISHMENTS FOR SELECTED HOUSING, ECONOMIC DEVELOPMENT, PUBLIC IMPROVEMENT, AND PUBLIC SERVICE ACTIVITIES. PROFILES FOR GRANTEES WILL VARY, AS GRANTEES HAVE FLEXIBILITY IN DETERMINING THE HOUSING, ECONOMIC, AND COMMUNITY DEVELOPMENT ACTIVITIES THEY CARRY OUT WITH CDBG FUNDS. THE MOST RECENT ACCOMPLISHMENTS CAN BE VIEWED WITHIN THE NATIONAL ACCOMPLISHMENT REPORTS LOCATED AT: HTTPS://WWW.HUDEXCHANGE.INFO/PROGRAMS/CDBG/CDBG-ACCOMPLISHMENT-REPORTS/; EXPECTED OUTCOMES: THE CDBG PROGRAM REINFORCES SEVERAL IMPORTANT VALUES AND PRINCIPLES OF COMMUNITY DEVELOPMENT: PROGRAM FLEXIBILITY TO EMPOWER PEOPLE AND COMMUNITIES TO DESIGN AND IMPLEMENT STRATEGIES TAILORED TO THEIR OWN NEEDS AND PRIORITIES; AN EMPHASIS ON CONSOLIDATED PLANNING THAT EXPANDS AND STRENGTHENS PARTNERSHIPS AMONG ALL LEVELS OF GOVERNMENT AND THE PRIVATE SECTOR IN ENHANCING COMMUNITY DEVELOPMENT; TECHNICAL ASSISTANCE ACTIVITIES AND SET-ASIDE FOR GRANTEES TO BUILD THE CAPACITY OF THESE PARTNERS. EACH CDBG GRANTEE’S EXPECTED OUTCOMES ARE DESCRIBED AS GOALS IN THEIR CONSOLIDATED PLAN. THE MOST RECENT CONSOLIDATED PLANS CAN BE VIEWED AT: HTTPS://WWW.HUDEXCHANGE.INFO/GRANTEES/REPORTS/#CONSOLIDATED-PLANS-ANNUAL-ACTION-PLANS-AND-CAPERS; INTENDED BENEFICIARIES: OVER A 1, 2, OR 3-YEAR PERIOD, AS SELECTED BY THE GRANTEE, NOT LESS THAN 70 PERCENT OF CDBG FUNDS MUST BE USED FOR ACTIVITIES THAT BENEFIT LOW- AND MODERATE-INCOME PERSONS. HUD DOES NOT PROVIDE CDBG ASSISTANCE DIRECTLY TO INDIVIDUALS, BUSINESSES, NONPROFIT OR ORGANIZATIONS OR OTHER NON-GOVERNMENTAL ENTITIES. INDIVIDUALS WHO ARE INTERESTED IN PARTICIPATING IN THIS PROGRAM, SHOULD CONTACT THEIR LOCAL MUNICIPAL OR COUNTY OFFICIALS TO FIND OUT HOW THE PROGRAM OPERATES IN THEIR COMMUNITY. PARTICIPATION REQUIREMENTS MAY DIFFER FROM ONE GRANTEE TO ANOTHER. WITH THE EXCEPTION OF THE STATE CDBG PROGRAM, THE LOCAL GOVERNMENT GRANTEE ADMINISTERS THE CDBG PROGRAM AND DETERMINES WHICH LOCAL PROJECTS RECEIVE FUNDING. ELIGIBLE GRANTEES ARE AS FOLLOWS: PRINCIPAL CITIES OF METROPOLITAN STATISTICAL AREAS (MSAS); OTHER METROPOLITAN CITIES WITH POPULATIONS OF AT LEAST 50,000; QUALIFIED URBAN COUNTIES WITH POPULATIONS OF AT LEAST 200,000 (EXCLUDING THE POPULATION OF ENTITLED CITIES); STATES AND INSULAR AREAS. THE DISTRICT OF COLUMBIA IS FUNDED UNDER THE CDBG ENTITLEMENT PROGRAM. THE STATE OF HAWAII DOES NOT PARTICIPATE, AND HUD ALLOCATES THE STATE'S SHARE OF FUNDS TO THE THREE HAWAII NON-ENTITLED COUNTIES. THE STATES ADMINISTER CDBG FUNDS IN THE STATE CDBG PROGRAM. SINCE STATES ARE IN THE BEST POSITION TO KNOW, AND TO RESPOND TO, THE NEEDS OF LOCAL GOVERNMENTS, CONGRESS AMENDED THE HOUSING AND COMMUNITY DEVELOPMENT ACT OF 1974 (HCD ACT) IN 1981 TO GIVE EACH STATE THE OPPORTUNITY TO ADMINISTER CDBG FUNDS FOR NON-ENTITLEMENT AREAS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

PURPOSE: CONSTRUCT/EXPAND HANGAR. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT CONSTRUCTS A NEW 9,400 SQUARE FOOT SPONSOR-OWNED HANGAR FOR AIRCRAFT STORAGE TO ASSIST THE AIRPORT TO BE AS SELF-SUSTAINING AS POSSIBLE BY GENERATING REVENUE. THIS PROJECT IS ALLOWABLE UNDER THE INFRASTRUCTURE INVESTMENT AND JOBS ACT'S EXPANDED ELIGIBILITY. THIS GRANT FUNDS A PORTION OF THE FINAL PHASE, WHICH CONSISTS OF CONSTRUCTION. THIS GRANT IS ASSOCIATED WITH AN AIRPORT IMPROVEMENT PROGRAM AND INFRASTRUCTURE INVESTMENT AND JOBS ACT GRANT THAT FUND THE REMAINING ELIGIBLE PORTION OF THE PROJECT. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH LEOTI, KANSAS.

COMMUNITY DEVELOPMENT BLOCK GRANTS/ENTITLEMENT GRANTS

PURPOSE: THE COMMUNITY DEVELOPMENT BLOCK GRANT (CDBG) PROGRAM PROVIDES ANNUAL GRANTS ON A FORMULA BASIS TO STATES, CITIES, AND COUNTIES TO DEVELOP VIABLE URBAN COMMUNITIES BY PROVIDING DECENT HOUSING AND A SUITABLE LIVING ENVIRONMENT, AND BY EXPANDING ECONOMIC OPPORTUNITIES, PRINCIPALLY FOR LOW- AND MODERATE-INCOME PERSONS. THE PROGRAM IS AUTHORIZED UNDER TITLE 1 OF THE HOUSING AND COMMUNITY DEVELOPMENT ACT OF 1974, PUBLIC LAW 93-383, AS AMENDED 42 U.S.C. 5301 ET SEQ. THE CDBG PROGRAM COVERS FOUR DISTINCT PROGRAMS, EACH WITH THEIR OWN SET OF GOVERNING REGULATIONS: CDBG ENTITLEMENT, CDBG NON-ENTITLED COUNTIES IN HAWAII, CDBG INSULAR AREAS, AND STATE CDBG. IN THE CDBG ENTITLEMENT PROGRAM, HUD AWARDS GRANTS TO ENTITLEMENT COMMUNITY GRANTEES TO CARRY OUT A WIDE RANGE OF COMMUNITY DEVELOPMENT ACTIVITIES. ENTITLEMENT COMMUNITIES DEVELOP THEIR OWN PROGRAMS AND FUNDING PRIORITIES. IN THE CDBG NON-ENTITLED COUNTIES IN HAWAII PROGRAM, THREE COUNTIES QUALIFY: HAWAII, KAUAI, AND MAUI. THE FY 2004 APPROPRIATIONS ACT REQUIRED THE GOVERNOR OF HAWAII TO DECIDE IF THE STATE WISHED TO PARTICIPATE IN THE STATE CDBG PROGRAM BY JULY 31, 2004. THE STATE MADE THE DECISION NOT TO PARTICIPATE IN THE PROGRAM. AS A RESULT OF THIS DECISION HUD'S HONOLULU FIELD OFFICE ADMINISTERS THE NON-ENTITLED GRANTS IN HAWAII. FUNDS ARE ALLOCATED USING A FORMULA BASED ON POPULATION, POVERTY, AND HOUSING OVERCROWDING, WITH THE POVERTY FACTOR CARRYING A DOUBLE WEIGHT. FOR THE CDBG INSULAR AREAS PROGRAM, HUD ANNUALLY ALLOCATES CDBG GRANTS TO FOUR DESIGNATED AREAS: AMERICAN SAMOA; GUAM; NORTHERN MARIANA ISLANDS; AND THE U.S. VIRGIN ISLANDS. THE FUNDS ARE ALLOCATED IN PROPORTION TO THE POPULATIONS OF THE ELIGIBLE TERRITORIES. THE PROGRAM IS ADMINISTERED BY HUD'S FIELD OFFICES IN PUERTO RICO AND HAWAII. UNDER THE STATE CDBG PROGRAM, STATES PASS THROUGH CDBG GRANTS TO UNITS OF GENERAL LOCAL GOVERNMENT. ANNUALLY, EACH STATE DEVELOPS FUNDING PRIORITIES AND CRITERIA FOR SELECTING PROJECTS. SINCE STATES ARE IN THE BEST POSITION TO KNOW, AND TO RESPOND TO, THE NEEDS OF LOCAL GOVERNMENTS, CONGRESS AMENDED THE HOUSING AND COMMUNITY DEVELOPMENT ACT OF 1974 (HCD ACT) IN 1981 TO GIVE EACH STATE THE OPPORTUNITY TO ADMINISTER CDBG FUNDS FOR NON-ENTITLEMENT AREAS. NON-ENTITLEMENT AREAS INCLUDE THOSE UNITS OF GENERAL LOCAL GOVERNMENT WHICH DO NOT RECEIVE CDBG FUNDS DIRECTLY FROM HUD. GENERALLY, NON-ENTITLEMENT AREAS ARE CITIES WITH POPULATIONS OF LESS THAN 50,000 (EXCEPT CITIES THAT ARE DESIGNATED PRINCIPAL CITIES OF METROPOLITAN STATISTICAL AREAS), AND COUNTIES WITH POPULATIONS OF LESS THAN 200,000. CURRENT CDBG AWARDS AND ALLOCATIONS ARE INCLUDED IN THIS LIST OF HUD COMMUNITY PLANNING AND DEVELOPMENT (CPD) AWARDS AND ALLOCATIONS LOCATED AT: HTTPS://WWW.HUDEXCHANGE.INFO/GRANTEES/ALLOCATIONS-AWARDS/; ACTIVITIES TO BE PERFORMED: CDBG FUNDS MAY BE USED FOR ACTIVITIES WHICH INCLUDE, BUT ARE NOT LIMITED TO: ACQUISITION OF REAL PROPERTY; RELOCATION AND DEMOLITION; REHABILITATION OF RESIDENTIAL AND NON-RESIDENTIAL STRUCTURES; CONSTRUCTION OF PUBLIC FACILITIES AND IMPROVEMENTS, SUCH AS WATER AND SEWER FACILITIES, STREETS, NEIGHBORHOOD CENTERS, AND THE CONVERSION OF SCHOOL BUILDINGS FOR ELIGIBLE PURPOSES; PUBLIC SERVICES, WITHIN CERTAIN LIMITS; ACTIVITIES RELATING TO ENERGY CONSERVATION AND RENEWABLE ENERGY RESOURCES; PROVISION OF ASSISTANCE TO PROFIT-MOTIVATED BUSINESSES TO CARRY OUT ECONOMIC DEVELOPMENT AND JOB CREATION/RETENTION ACTIVITIES. EACH ACTIVITY MUST MEET ONE OF THE FOLLOWING NATIONAL OBJECTIVES FOR THE PROGRAM: BENEFIT LOW- AND MODERATE-INCOME PERSONS, PREVENTION OR ELIMINATION OF SLUMS OR BLIGHT, OR ADDRESS COMMUNITY DEVELOPMENT NEEDS HAVING A PARTICULAR URGENCY BECAUSE EXISTING CONDITIONS POSE A SERIOUS AND IMMEDIATE THREAT TO THE HEALTH OR WELFARE OF THE COMMUNITY FOR WHICH OTHER FUNDING IS NOT AVAILABLE. GENERALLY, THE FOLLOWING TYPES OF ACTIVITIES ARE INELIGIBLE: ACQUISITION, CONSTRUCTION, OR RECONSTRUCTION OF BUILDINGS FOR THE GENERAL CONDUCT OF GOVERNMENT; POLITICAL ACTIVITIES; CERTAIN INCOME PAYMENTS; CONSTRUCTION OF NEW HOUSING (WITH SOME EXCEPTIONS). UNDER THE STATE CDBG PROGRAM, STATES MAY USE $100,000 PLUS UP TO A MAXIMUM OF THREE PERCENT OF ITS CDBG ALLOCATION. AMOUNTS EXPENDED ON ADMINISTRATION IN EXCESS OF $100,000 MUST BE MATCHED. STATES MAY EXPEND UP TO THREE PERCENT OF THEIR CDBG ALLOCATION ON TECHNICAL ASSISTANCE ACTIVITIES. HOWEVER, THE TOTAL A STATE SPENDS ON BOTH ADMINISTRATIVE AND TECHNICAL ASSISTANCE EXPENSES MAY NOT EXCEED $100,000 PLUS THREE PERCENT OF THE STATE'S ALLOCATION. CPD HAS DEVELOPED PROFILES THAT DISPLAY GRANTEE-REPORTED ACCOMPLISHMENTS FOR SELECTED HOUSING, ECONOMIC DEVELOPMENT, PUBLIC IMPROVEMENT, AND PUBLIC SERVICE ACTIVITIES. PROFILES FOR GRANTEES WILL VARY, AS GRANTEES HAVE FLEXIBILITY IN DETERMINING THE HOUSING, ECONOMIC, AND COMMUNITY DEVELOPMENT ACTIVITIES THEY CARRY OUT WITH CDBG FUNDS. THE MOST RECENT ACCOMPLISHMENTS CAN BE VIEWED WITHIN THE NATIONAL ACCOMPLISHMENT REPORTS LOCATED AT: HTTPS://WWW.HUDEXCHANGE.INFO/PROGRAMS/CDBG/CDBG-ACCOMPLISHMENT-REPORTS/; EXPECTED OUTCOMES: THE CDBG PROGRAM REINFORCES SEVERAL IMPORTANT VALUES AND PRINCIPLES OF COMMUNITY DEVELOPMENT: PROGRAM FLEXIBILITY TO EMPOWER PEOPLE AND COMMUNITIES TO DESIGN AND IMPLEMENT STRATEGIES TAILORED TO THEIR OWN NEEDS AND PRIORITIES; AN EMPHASIS ON CONSOLIDATED PLANNING THAT EXPANDS AND STRENGTHENS PARTNERSHIPS AMONG ALL LEVELS OF GOVERNMENT AND THE PRIVATE SECTOR IN ENHANCING COMMUNITY DEVELOPMENT; TECHNICAL ASSISTANCE ACTIVITIES AND SET-ASIDE FOR GRANTEES TO BUILD THE CAPACITY OF THESE PARTNERS. EACH CDBG GRANTEE’S EXPECTED OUTCOMES ARE DESCRIBED AS GOALS IN THEIR CONSOLIDATED PLAN. THE MOST RECENT CONSOLIDATED PLANS CAN BE VIEWED AT: HTTPS://WWW.HUDEXCHANGE.INFO/GRANTEES/REPORTS/#CONSOLIDATED-PLANS-ANNUAL-ACTION-PLANS-AND-CAPERS; INTENDED BENEFICIARIES: OVER A 1, 2, OR 3-YEAR PERIOD, AS SELECTED BY THE GRANTEE, NOT LESS THAN 70 PERCENT OF CDBG FUNDS MUST BE USED FOR ACTIVITIES THAT BENEFIT LOW- AND MODERATE-INCOME PERSONS. HUD DOES NOT PROVIDE CDBG ASSISTANCE DIRECTLY TO INDIVIDUALS, BUSINESSES, NONPROFIT OR ORGANIZATIONS OR OTHER NON-GOVERNMENTAL ENTITIES. INDIVIDUALS WHO ARE INTERESTED IN PARTICIPATING IN THIS PROGRAM, SHOULD CONTACT THEIR LOCAL MUNICIPAL OR COUNTY OFFICIALS TO FIND OUT HOW THE PROGRAM OPERATES IN THEIR COMMUNITY. PARTICIPATION REQUIREMENTS MAY DIFFER FROM ONE GRANTEE TO ANOTHER. WITH THE EXCEPTION OF THE STATE CDBG PROGRAM, THE LOCAL GOVERNMENT GRANTEE ADMINISTERS THE CDBG PROGRAM AND DETERMINES WHICH LOCAL PROJECTS RECEIVE FUNDING. ELIGIBLE GRANTEES ARE AS FOLLOWS: PRINCIPAL CITIES OF METROPOLITAN STATISTICAL AREAS (MSAS); OTHER METROPOLITAN CITIES WITH POPULATIONS OF AT LEAST 50,000; QUALIFIED URBAN COUNTIES WITH POPULATIONS OF AT LEAST 200,000 (EXCLUDING THE POPULATION OF ENTITLED CITIES); STATES AND INSULAR AREAS. THE DISTRICT OF COLUMBIA IS FUNDED UNDER THE CDBG ENTITLEMENT PROGRAM. THE STATE OF HAWAII DOES NOT PARTICIPATE, AND HUD ALLOCATES THE STATE'S SHARE OF FUNDS TO THE THREE HAWAII NON-ENTITLED COUNTIES. THE STATES ADMINISTER CDBG FUNDS IN THE STATE CDBG PROGRAM. SINCE STATES ARE IN THE BEST POSITION TO KNOW, AND TO RESPOND TO, THE NEEDS OF LOCAL GOVERNMENTS, CONGRESS AMENDED THE HOUSING AND COMMUNITY DEVELOPMENT ACT OF 1974 (HCD ACT) IN 1981 TO GIVE EACH STATE THE OPPORTUNITY TO ADMINISTER CDBG FUNDS FOR NON-ENTITLEMENT AREAS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

IMPROVE EXISTING AIRPORT

UNKNOWN TITLE

ENTITLED CITIES

COMMUNITY DEVELOPMENT BLOCK GRANTS/ENTITLEMENT GRANTS

COMMUNITY DEVELOPMENT BLOCK GRANTS/ENTITLEMENT GRANTS

COMMUNITY DEVELOPMENT BLOCK GRANTS/ENTITLEMENT GRANTS

PURPOSE: THIS PROJECT PROVIDES FUNDING TO LEONARDO ACADEMY TO REPLACE 10 OLD DIESEL POWERED SCHOOL BUSES WITH NEW PROPANE POWERED SCHOOL BUSES. ACTIVITIES TO BE PERFORMED: THIS PROJECT INCLUDES REPLACEMENT OF 10 OLDER DIESEL POWERED SCHOOL BUSES WITH 10 NEW SCHOOL BUSES POWERED BY PROPANE. IN ADDITION, THE RECIPIENT IS REQUIRED TO PROVIDE QUARTERLY PROGRESS REPORTS AND A FINAL REPORT DEMONSTRATING THE TERMS AND CONDITIONS OF THE GRANT HAD BEEN MET. EXPECTED OUTCOMES: THIS PROJECT WILL RESULT IN THE REDUCTION OF DIESEL EMISSIONS WHICH ARE HAZARDOUS TO HUMAN HEALTH AND THE ENVIRONMENT. RESULTING IN LIFETIME EMISSION REDUCTION IN NOX - 4.1 TONS OR 94%, PM2.5 - .35 TONS OR 96% ND CO2 210.3 TONS OR 24%. INTENDED BENEFICIARIES: DIRECT BENEFICIARIES OF PROGRAM INCLUDE THE RECIPIENTS OF THE DERA FUNDS AS WELL AS RESIDENTS OF THE LOCAL COMMUNITIES WHERE THE VEHICLES OR EQUIPMENT OPERATE. SUBRECIPIENT ACTIVITIES: THERE ARE NO SUBRECIPIENTS AFFILIATED WITH THESE PROJECTS. BENEFICIARIES OF THE FUNDS, HOWEVER, ARE RESPONSIBLE FOR THE PROCUREMENT OF REPLACEMENT OR RETROFIT TECHNOLOGY AND PROVIDING THE GRANTEE ITS PROGRESS AND COMPLETING THE PROJECT AS REQUIRED UNDER THE TERMS AND CONDITIONS.

THE PURPOSE OF THE COPS OFFICE SCHOOL VIOLENCE PREVENTION PROGRAM (SVPP) IS TO IMPROVE SECURITY AT SCHOOLS AND ON SCHOOL GROUNDS THROUGH SCHOOL SAFETY PROGRAMS AND TECHNOLOGY. FUNDING UNDER THIS AWARD PROGRAM WILL BE USED BY THE SCHOOL JURISDICTION TO IMPLEMENT EVIDENCE-BASED PROGRAMS TO IMPROVE SCHOOL SECURITY AND PROMOTE A POSITIVE LEARNING ENVIRONMENT FOR ALL STUDENTS.

PURPOSE: THE COMMUNITY DEVELOPMENT BLOCK GRANT (CDBG) PROGRAM PROVIDES ANNUAL GRANTS ON A FORMULA BASIS TO STATES, CITIES, AND COUNTIES TO DEVELOP VIABLE URBAN COMMUNITIES BY PROVIDING DECENT HOUSING AND A SUITABLE LIVING ENVIRONMENT, AND BY EXPANDING ECONOMIC OPPORTUNITIES, PRINCIPALLY FOR LOW- AND MODERATE-INCOME PERSONS. THE PROGRAM IS AUTHORIZED UNDER TITLE 1 OF THE HOUSING AND COMMUNITY DEVELOPMENT ACT OF 1974, PUBLIC LAW 93-383, AS AMENDED 42 U.S.C. 5301 ET SEQ. THE CDBG PROGRAM COVERS FOUR DISTINCT PROGRAMS, EACH WITH THEIR OWN SET OF GOVERNING REGULATIONS: CDBG ENTITLEMENT, CDBG NON-ENTITLED COUNTIES IN HAWAII, CDBG INSULAR AREAS, AND STATE CDBG. IN THE CDBG ENTITLEMENT PROGRAM, HUD AWARDS GRANTS TO ENTITLEMENT COMMUNITY GRANTEES TO CARRY OUT A WIDE RANGE OF COMMUNITY DEVELOPMENT ACTIVITIES. ENTITLEMENT COMMUNITIES DEVELOP THEIR OWN PROGRAMS AND FUNDING PRIORITIES. IN THE CDBG NON-ENTITLED COUNTIES IN HAWAII PROGRAM, THREE COUNTIES QUALIFY: HAWAII, KAUAI, AND MAUI. THE FY 2004 APPROPRIATIONS ACT REQUIRED THE GOVERNOR OF HAWAII TO DECIDE IF THE STATE WISHED TO PARTICIPATE IN THE STATE CDBG PROGRAM BY JULY 31, 2004. THE STATE MADE THE DECISION NOT TO PARTICIPATE IN THE PROGRAM. AS A RESULT OF THIS DECISION HUD'S HONOLULU FIELD OFFICE ADMINISTERS THE NON-ENTITLED GRANTS IN HAWAII. FUNDS ARE ALLOCATED USING A FORMULA BASED ON POPULATION, POVERTY, AND HOUSING OVERCROWDING, WITH THE POVERTY FACTOR CARRYING A DOUBLE WEIGHT. FOR THE CDBG INSULAR AREAS PROGRAM, HUD ANNUALLY ALLOCATES CDBG GRANTS TO FOUR DESIGNATED AREAS: AMERICAN SAMOA; GUAM; NORTHERN MARIANA ISLANDS; AND THE U.S. VIRGIN ISLANDS. THE FUNDS ARE ALLOCATED IN PROPORTION TO THE POPULATIONS OF THE ELIGIBLE TERRITORIES. THE PROGRAM IS ADMINISTERED BY HUD'S FIELD OFFICES IN PUERTO RICO AND HAWAII. UNDER THE STATE CDBG PROGRAM, STATES PASS THROUGH CDBG GRANTS TO UNITS OF GENERAL LOCAL GOVERNMENT. ANNUALLY, EACH STATE DEVELOPS FUNDING PRIORITIES AND CRITERIA FOR SELECTING PROJECTS. SINCE STATES ARE IN THE BEST POSITION TO KNOW, AND TO RESPOND TO, THE NEEDS OF LOCAL GOVERNMENTS, CONGRESS AMENDED THE HOUSING AND COMMUNITY DEVELOPMENT ACT OF 1974 (HCD ACT) IN 1981 TO GIVE EACH STATE THE OPPORTUNITY TO ADMINISTER CDBG FUNDS FOR NON-ENTITLEMENT AREAS. NON-ENTITLEMENT AREAS INCLUDE THOSE UNITS OF GENERAL LOCAL GOVERNMENT WHICH DO NOT RECEIVE CDBG FUNDS DIRECTLY FROM HUD. GENERALLY, NON-ENTITLEMENT AREAS ARE CITIES WITH POPULATIONS OF LESS THAN 50,000 (EXCEPT CITIES THAT ARE DESIGNATED PRINCIPAL CITIES OF METROPOLITAN STATISTICAL AREAS), AND COUNTIES WITH POPULATIONS OF LESS THAN 200,000. CURRENT CDBG AWARDS AND ALLOCATIONS ARE INCLUDED IN THIS LIST OF HUD COMMUNITY PLANNING AND DEVELOPMENT (CPD) AWARDS AND ALLOCATIONS LOCATED AT: HTTPS://WWW.HUDEXCHANGE.INFO/GRANTEES/ALLOCATIONS-AWARDS/; ACTIVITIES TO BE PERFORMED: CDBG FUNDS MAY BE USED FOR ACTIVITIES WHICH INCLUDE, BUT ARE NOT LIMITED TO: ACQUISITION OF REAL PROPERTY; RELOCATION AND DEMOLITION; REHABILITATION OF RESIDENTIAL AND NON-RESIDENTIAL STRUCTURES; CONSTRUCTION OF PUBLIC FACILITIES AND IMPROVEMENTS, SUCH AS WATER AND SEWER FACILITIES, STREETS, NEIGHBORHOOD CENTERS, AND THE CONVERSION OF SCHOOL BUILDINGS FOR ELIGIBLE PURPOSES; PUBLIC SERVICES, WITHIN CERTAIN LIMITS; ACTIVITIES RELATING TO ENERGY CONSERVATION AND RENEWABLE ENERGY RESOURCES; PROVISION OF ASSISTANCE TO PROFIT-MOTIVATED BUSINESSES TO CARRY OUT ECONOMIC DEVELOPMENT AND JOB CREATION/RETENTION ACTIVITIES. EACH ACTIVITY MUST MEET ONE OF THE FOLLOWING NATIONAL OBJECTIVES FOR THE PROGRAM: BENEFIT LOW- AND MODERATE-INCOME PERSONS, PREVENTION OR ELIMINATION OF SLUMS OR BLIGHT, OR ADDRESS COMMUNITY DEVELOPMENT NEEDS HAVING A PARTICULAR URGENCY BECAUSE EXISTING CONDITIONS POSE A SERIOUS AND IMMEDIATE THREAT TO THE HEALTH OR WELFARE OF THE COMMUNITY FOR WHICH OTHER FUNDING IS NOT AVAILABLE. GENERALLY, THE FOLLOWING TYPES OF ACTIVITIES ARE INELIGIBLE: ACQUISITION, CONSTRUCTION, OR RECONSTRUCTION OF BUILDINGS FOR THE GENERAL CONDUCT OF GOVERNMENT; POLITICAL ACTIVITIES; CERTAIN INCOME PAYMENTS; CONSTRUCTION OF NEW HOUSING (WITH SOME EXCEPTIONS). UNDER THE STATE CDBG PROGRAM, STATES MAY USE $100,000 PLUS UP TO A MAXIMUM OF THREE PERCENT OF ITS CDBG ALLOCATION. AMOUNTS EXPENDED ON ADMINISTRATION IN EXCESS OF $100,000 MUST BE MATCHED. STATES MAY EXPEND UP TO THREE PERCENT OF THEIR CDBG ALLOCATION ON TECHNICAL ASSISTANCE ACTIVITIES. HOWEVER, THE TOTAL A STATE SPENDS ON BOTH ADMINISTRATIVE AND TECHNICAL ASSISTANCE EXPENSES MAY NOT EXCEED $100,000 PLUS THREE PERCENT OF THE STATE'S ALLOCATION. CPD HAS DEVELOPED PROFILES THAT DISPLAY GRANTEE-REPORTED ACCOMPLISHMENTS FOR SELECTED HOUSING, ECONOMIC DEVELOPMENT, PUBLIC IMPROVEMENT, AND PUBLIC SERVICE ACTIVITIES. PROFILES FOR GRANTEES WILL VARY, AS GRANTEES HAVE FLEXIBILITY IN DETERMINING THE HOUSING, ECONOMIC, AND COMMUNITY DEVELOPMENT ACTIVITIES THEY CARRY OUT WITH CDBG FUNDS. THE MOST RECENT ACCOMPLISHMENTS CAN BE VIEWED WITHIN THE NATIONAL ACCOMPLISHMENT REPORTS LOCATED AT: HTTPS://WWW.HUDEXCHANGE.INFO/PROGRAMS/CDBG/CDBG-ACCOMPLISHMENT-REPORTS/; EXPECTED OUTCOMES: THE CDBG PROGRAM REINFORCES SEVERAL IMPORTANT VALUES AND PRINCIPLES OF COMMUNITY DEVELOPMENT: PROGRAM FLEXIBILITY TO EMPOWER PEOPLE AND COMMUNITIES TO DESIGN AND IMPLEMENT STRATEGIES TAILORED TO THEIR OWN NEEDS AND PRIORITIES; AN EMPHASIS ON CONSOLIDATED PLANNING THAT EXPANDS AND STRENGTHENS PARTNERSHIPS AMONG ALL LEVELS OF GOVERNMENT AND THE PRIVATE SECTOR IN ENHANCING COMMUNITY DEVELOPMENT; TECHNICAL ASSISTANCE ACTIVITIES AND SET-ASIDE FOR GRANTEES TO BUILD THE CAPACITY OF THESE PARTNERS. EACH CDBG GRANTEE’S EXPECTED OUTCOMES ARE DESCRIBED AS GOALS IN THEIR CONSOLIDATED PLAN. THE MOST RECENT CONSOLIDATED PLANS CAN BE VIEWED AT: HTTPS://WWW.HUDEXCHANGE.INFO/GRANTEES/REPORTS/#CONSOLIDATED-PLANS-ANNUAL-ACTION-PLANS-AND-CAPERS; INTENDED BENEFICIARIES: OVER A 1, 2, OR 3-YEAR PERIOD, AS SELECTED BY THE GRANTEE, NOT LESS THAN 70 PERCENT OF CDBG FUNDS MUST BE USED FOR ACTIVITIES THAT BENEFIT LOW- AND MODERATE-INCOME PERSONS. HUD DOES NOT PROVIDE CDBG ASSISTANCE DIRECTLY TO INDIVIDUALS, BUSINESSES, NONPROFIT OR ORGANIZATIONS OR OTHER NON-GOVERNMENTAL ENTITIES. INDIVIDUALS WHO ARE INTERESTED IN PARTICIPATING IN THIS PROGRAM, SHOULD CONTACT THEIR LOCAL MUNICIPAL OR COUNTY OFFICIALS TO FIND OUT HOW THE PROGRAM OPERATES IN THEIR COMMUNITY. PARTICIPATION REQUIREMENTS MAY DIFFER FROM ONE GRANTEE TO ANOTHER. WITH THE EXCEPTION OF THE STATE CDBG PROGRAM, THE LOCAL GOVERNMENT GRANTEE ADMINISTERS THE CDBG PROGRAM AND DETERMINES WHICH LOCAL PROJECTS RECEIVE FUNDING. ELIGIBLE GRANTEES ARE AS FOLLOWS: PRINCIPAL CITIES OF METROPOLITAN STATISTICAL AREAS (MSAS); OTHER METROPOLITAN CITIES WITH POPULATIONS OF AT LEAST 50,000; QUALIFIED URBAN COUNTIES WITH POPULATIONS OF AT LEAST 200,000 (EXCLUDING THE POPULATION OF ENTITLED CITIES); STATES AND INSULAR AREAS. THE DISTRICT OF COLUMBIA IS FUNDED UNDER THE CDBG ENTITLEMENT PROGRAM. THE STATE OF HAWAII DOES NOT PARTICIPATE, AND HUD ALLOCATES THE STATE'S SHARE OF FUNDS TO THE THREE HAWAII NON-ENTITLED COUNTIES. THE STATES ADMINISTER CDBG FUNDS IN THE STATE CDBG PROGRAM. SINCE STATES ARE IN THE BEST POSITION TO KNOW, AND TO RESPOND TO, THE NEEDS OF LOCAL GOVERNMENTS, CONGRESS AMENDED THE HOUSING AND COMMUNITY DEVELOPMENT ACT OF 1974 (HCD ACT) IN 1981 TO GIVE EACH STATE THE OPPORTUNITY TO ADMINISTER CDBG FUNDS FOR NON-ENTITLEMENT AREAS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

ASSESSING PREFERENCES FOR EVERYDAY LIVING IN THE NURSING HOME: RELIABILITY AND CO

EVALUATION OF A SELECTIVE PPAR-GAMMA AGONIST FOR TREATMENT OF ALZHEIMER?S DISEASE

COMMUNITY DEVELOPMENT BLOCK GRANTS/ENTITLEMENT GRANTS

OLEOCANTHAL FUNCTIONAL FOOD PRODUCTS FOR BREAST CANCER RECURRENCE CONTROL

COMMUNITY DEVELOPMENT BLOCK GRANTS/ENTITLEMENT GRANTS

COMMUNITY DEVELOPMENT BLOCK GRANTS/ENTITLEMENT GRANTS

ENTITLED CITIES

OTHER-TECH

CHEMOSENSITIZATION OF GLIOBLASTOMA BY PROPENTOFYLLINE - SUMMARY GLIOBLASTOMA (GBM) IS THE MOST COMMON PRIMARY TUMOR OF THE CNS WITH LIMITED TREATMENT OPTIONS AND A POOR CLINICAL PROGNOSIS. STANDARD OF CARE TREATMENT, INCLUDING SURGICAL RESECTION, RADIATION THERAPY AND CONCURRENT TEMOZOLOMIDE (TMZ) TREATMENT FOLLOWED BY ADJUVANT TMZ, PRODUCES A MEDIAN SURVIVAL IN NEWLY DIAGNOSED GBM OF ~15 MONTHS. TUMOR RECURRENCE HAPPENS DUE TO THERAPY RESISTANT TUMOR CELLS; THEREFORE, THERAPEUTIC STRATEGIES THAT IMPROVE TUMOR CELL SENSITIVITY TO CHEMOTHERAPY ARE NEEDED TO IMPROVE PATIENT OUTCOMES. TROY (TNFRSF19), A MEMBER OF THE TNF RECEPTOR SUPERFAMILY, HAS RECENTLY BEEN DISCOVERED TO IMPACT GBM PROGRESSION. BRIEFLY, TROY EXPRESSION INCREASES WITH INCREASING GLIAL TUMOR GRADE AND INVERSELY CORRELATES WITH PATIENT SURVIVAL. INCREASED EXPRESSION OF TROY STIMULATES GBM CELL MIGRATION/INVASION IN VITRO AND IN VIVO AND INCREASES RESISTANCE TO TMZ OR RADIATION IN VITRO, WHILE KNOCKDOWN OF TROY EXPRESSION INHIBITS CELL INVASION, INCREASES SENSITIVITY TO TMZ, AND PROLONGS SURVIVAL IN A MURINE PATIENT-DERIVED XENOGRAFT (PDX) MODEL. THESE AND ADDITIONAL STUDIES INDICATE THAT TROY REPRESENTS A POTENTIAL NOVEL THERAPEUTIC TARGET FOR GBM. PROPENTOFYLLINE (PPF), A DRUG THAT HAS BEEN STUDIED IN NUMEROUS CLINICAL TRIALS FOR SEVERAL NON-GBM INDICATIONS, DOWNREGULATES TROY, INHIBITS GBM INVASION AND INCREASES SENSITIVITY IN VITRO AND IN VIVO TO TMZ AND RADIOTHERAPY. PPF EXHIBITS A WELL-CHARACTERIZED PHARMACOLOGICAL PROFILE, INCLUDING GOOD BRAIN DISTRIBUTION AND FAVORABLE SAFETY METRICS. REPURPOSING PPF COULD BE FASTER TO CLINICAL TRIALS, LESS RISKY AND LESS COSTLY THAN THE TRADITIONAL DRUG DEVELOPMENT PATHWAY FOR NEW CHEMICAL ENTITIES. THE PRIMARY GOAL OF THIS PROPOSAL IS TO TEST THE ABILITY OF PPF TO SENSITIZE GBM TO TMZ. SECONDARY GOALS INCLUDE ASSESSING: THE NECESSITY OF TROY FOR PPF ACTIVITY, THE MECHANISMS OF ACTION FOR PPF-INDUCED TROY DOWNREGULATION, AND THE IMPACT OF PPF TREATMENT AND TROY EXPRESSION ON TUMOR-PROMOTING MICROGLIA. THE FOLLOWING AIMS HAVE BEEN DESIGNED TO ANSWER THESE QUESTIONS. SPECIFIC AIM 1: TEST THE ABILITY OF PPF TO SENSITIZE TMZ RESISTANT GBM TUMORS TO THERAPEUTIC TREATMENT IN INTRACRANIAL PDX MODELS AND A SYNGENEIC MODEL. THE ABILITY OF PPF TO SENSITIZE GBM CELLS TO TMZ WILL BE EVALUATED IN FIVE TMZ RESISTANT PDX MOUSE MODELS AND ONE IMMUNOCOMPETENT SYNGENEIC MODEL. IVIS-MONITORING OF TUMOR GROWTH, DURATION OF SURVIVAL AS WELL AS HISTOPATHOLOGICAL AND MOLECULAR ANALYSIS OF TUMOR AND TUMOR MICROENVIRONMENT WILL BE EVALUATED. SPECIFIC AIM 2: CHARACTERIZE THE CELLULAR AND MOLECULAR TARGETS OF PPF TO PREDICT CLINICAL RESPONSIVENESS. LIVE-CELL AUTOMATED IMAGING AND MOLECULAR TECHNIQUES WILL BE USED TO HELP DEFINE THE CELLULAR AND MOLECULAR TARGETS OF PPF. WE WILL TEST THE ABILITY OF PPF TO SENSITIZE A DIVERSE PANEL OF 20 HUMAN GBM PDX LINES, REPRESENTING VARIED MOLECULAR AND PROGNOSTIC SUBTYPES, TO TMZ TREATMENT EX VIVO AND ASSESS THE EFFECTS OF PPF ON MICROGLIA IN VITRO.

ENTITLED CITIES

ENTITLED CITIES

ENTITLED CITIES

ARP ECONOMIC DEVELOPMENT GRANT FOR RURAL HEALTH CARE FACILITIES

THE ROCKWELL POND SANITARY SEWER LINE REPLACEMENT PROJECT IS PART OF A COMPREHENSIVE INFILTRATION AND INFLOW (I/I) REDUCTION PROGRAM FOR THE ROCKWE

WASTE DISPOSAL GRANTS - REGULAR

IMPROVING THE STORAGE CONDITIONS AND BEGINNING DIGITIZATION OF THE PALEOZOIC STRATIGRAPHIC FOSSIL COLLECTIONS AT THE PALEONTOLOGICAL RESEARCH INSTITUTION

WASTE DISPOSAL GRANTS - REGULAR

CONFINEMENT, PLASMA BOUNDARY AND EQUILIBRIUM RECONSTRUCTION IN LTX-BETA IN PRESENCE OF NBI

ASSISTANCE TO FIREFIGHTERS GRANT

THE LEON COUNTY SHERIFF'S OFFICE (LCSO) PROPOSES TO UTILIZE BJA FY 2023 BODY-WORN CAMERA POLICY AND IMPLEMENTATION PROGRAM (BWCPIP) FUNDING TO EXPAND LCSO'S EXISTING BODY-WORN CAMERA (BWC) PROGRAM. EXPECTED OUTCOMES INCLUDE IMPROVED OFFICER SAFETY, EVIDENCE COLLECTION, TRANSPARENCY AND ACCOUNTABILITY IN LAW ENFORCEMENT PRACTICES, REDUCED EXCESSIVE USE OF FORCE INCIDENTS, AND IMPROVED COMMUNITY RELATIONS AND TRUST. SWORN LAW ENFORCEMENT OFFICERS AND THE CITIZENS OF LEON COUNTY ARE THE INTENDED BENEFICIARIES OF THE PROJECT. THE BWCS ACQUIRED UNDER THIS AWARD WILL CONTINUE TO BE UTILIZED AS A TRAINING TOOL TO IMPROVE OFFICER PERFORMANCE, DE-ESCALATION SKILLS, AND EVIDENCE-GATHERING TECHNIQUES. LEON COUNTY RESIDENTS WILL BENEFIT FROM THE INCREASED TRANSPARENCY AND ACCOUNTABILITY OF LAW ENFORCEMENT OFFICERS USING THE BWCS, FURTHER ADVANCING LCSO'S EFFORTS TO BUILD TRUST BETWEEN THE COMMUNITY AND LAW ENFORCEMENT. SPECIFIC ACTIVITIES WILL INCLUDE THE PURCHASE OF NEW EQUIPMENT AND EXPANDING TECHNICAL SUPPORT FOR THE ADDITIONAL CAMERAS (E.G., CHARGING, DOWNLOADING VIDEO/AUDIO, ETC.). LCSO HAS DEVELOPED EXPANDED POLICIES FOR CAMERA IMPLEMENTATION FOR USE IN CORRECTIONS SETTINGS, DEVELOPED TRAINING TO IMPLEMENT ADDITIONAL BWCS, AND DEVELOPED AN EVALUATION PROCESS TO ENSURE SUCCESSFUL EXPANSION. THE LCSO WILL ALSO MEET REGULARLY WITH THE ASSIGNED TRAINING AND TECHNICAL ASSISTANCE PROVIDER FOR GUIDANCE, EVALUATION, AND IMPLEMENTATION OF RECOMMENDED CHANGES.

TOWN OF LEONVILLE PROPOSES VARIOUS IMPROVEMENTS TO THE TOWNS WASTEWATER TREATMENT FACILITY TO ACHIEVE COMPLIANCE

CONTINUED DEVELOPMENT OF A COMMUNITY-BASED MARINE TURTLE CONSERVATION PROGRAM FOR SIERRA LEONE AND LEATHERBACK CONSERVATION INITIATIVE AT TURTLE, BONTHE/SHERBRO ISLANDS AND THE SOUTHERN SHORELINE

RURAL HEALTH NETWORK DEVELOPMENT PROGRAM

DIGITIZATION TCN: COLLABORATIVE: DOCUMENTING FOSSIL MARINE INVERTEBRATE COMMUNITIES OF THE EASTERN PACIFIC: FAUNAL RESPONSES TO ENVIRONMENTAL CHANGE

BUILDING RETROFIT BLOCK GRANT

BUILDING ON THE PAST FOR THE FUTURE: RESEARCH LABORATORIES FOR THE PALEONTOLOGICAL RESEARCH INSTITUTION

THE LEON COUNTY SHERIFF'S OFFICE WILL USE FY24 SAFER OUTCOMES FUNDING TO DELIVER CURRICULUM DEVELOPED FROM DATA GATHERED FROM ENCOUNTERS AND INTERACTIONS BETWEEN CITIZENS AND LCSO DEPUTIES. DATA COLLECTION SOURCES INCLUDE THE COMPUTER-AIDED DISPATCHING (CAD) SYSTEM, LCSO'S RESPONSE TO RESISTANCE REPORTING SYSTEM, LCSO'S VIDEO EVIDENCE (BODY-WORN CAMERA) COLLECTION AND STORAGE SYSTEM, EMPLOYEE MANAGEMENT DATABASES, AND MEMBER QUESTIONNAIRES. THIS TRAINING INCORPORATES ADVANCED DE-ESCALATION TECHNIQUES THAT CENTER ON UNDERSTANDING AND ADDRESSING THE ROOT CAUSES OF CONFRONTATIONAL BEHAVIOR, ALIGNING WITH THE PRINCIPLES OF COMMUNITY-ORIENTED POLICING, WHICH EMPHASIZE TRUST, MUTUAL RESPECT, AND COLLABORATION BETWEEN LAW ENFORCEMENT AND COMMUNITY MEMBERS. BY EQUIPPING DEPUTIES WITH THESE VITAL SKILLS, LCSO STRENGTHENS ITS COMMITMENT TO SERVING THE COMMUNITY THROUGH NON-ADVERSARIAL MEANS. THE TRAINING ALSO INCLUDES BRAIN CHEMISTRY AND ANATOMY COMPONENTS, GIVING OFFICERS A BETTER UNDERSTANDING OF HUMAN BEHAVIOR AND REACTIONS AND PROMOTING EMPATHETIC AND INFORMED RESPONSES. AS DEPUTIES APPLY THESE TECHNIQUES SUCCESSFULLY, COMMUNITY PERCEPTIONS OF LAW ENFORCEMENT ARE EXPECTED TO IMPROVE, FOSTERING A MORE COLLABORATIVE AND SUPPORTIVE RELATIONSHIP. THIS ENHANCEMENT OF DE-ESCALATION CAPABILITIES WILL SIGNIFICANTLY CONTRIBUTE TO LCSO'S MISSION OF ENSURING PUBLIC SAFETY WHILE BUILDING STRONGER COMMUNITY TIES AND TRUST.

TELEMEDICINE GRANT

THIS ASSISTANCE AGREEMENT PROVIDES FUNDING TO THE LEON COUNTY DISTRICT SCHOOL BOARD UNDER THE AMERICAN RECOVERY & REINVESTMENT ACT OF 2009 TO PURCHA

MASTER PLAN STUDY

EVALUATION OF ORAL OLEOCANTHAL TO PREVENT AND/OR TREAT ALZHEIMER?S DISEASE AND RELATED DEMENTIAS

UNDERSTANDING NBI HEATING AND FUELING IN LTX-SS TOKAMAK

PURPOSE: CONSTRUCT/EXPAND HANGAR. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT CONSTRUCTS A NEW 9,400 SQUARE FOOT SPONSOR-OWNED HANGAR FOR AIRCRAFT STORAGE TO ASSIST THE AIRPORT TO BE AS SELF-SUSTAINING AS POSSIBLE BY GENERATING REVENUE. THE SPONSOR HAS ADEQUATELY FINANCED THE AIRSIDE NEEDS OF THE AIRPORT. THIS GRANT FUNDS PHASE 1, WHICH CONSISTS OF DESIGN. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH LEOTI, KANSAS.

COMMUNITY-LED MONITORING OF HIV SERVICES IN MULTIPLE PEPFAR COUNTRIES

THIS AGREEMENT WILL PROVIDE ASSISTANCE TO LEONARDO ACADEMY INCORPORATED (LEONARDO ACADEMY) IN ITS EFFORTS TO REDUCE DIESEL EMISSIONS AND EXPOSURE IN WILL COUNTY, ILLINOIS, AND THE COUNTIES OF HENNEPIN AND WASHINGTON IN MINNESOTA. LEONARDO ACADEMY'S PROJECT WILL PROVIDE FOR THE EARLY REPLACEMENT OF FOUR NON-TIER DIESEL ENGINE CRANES WITH NEWER CRANES THAT HAVE TIER 4 DIESEL ENGINES. THIS PROJECT WILL REDUCE EMISSIONS OF DIESEL PARTICULATE MATTER AND OTHER POLLUTANTS SUCH AS NITROGEN OXIDES, CARBON MONOXIDE AND HYDROCARBONS.

REPURPOSING PYRVINIUM AS AN INHALATION THERAPY FOR IDIOPATHIC PULMONARY FIBROSIS - SUMMARY IDIOPATHIC PULMONARY FIBROSIS (IPF) IS A FIBROSING INTERSTITIAL LUNG DISEASE THAT IS CHARACTERIZED BY PROGRESSIVE DECLINE IN LUNG FUNCTION DUE TO INFLAMMATORY AND FIBROTIC CHANGES OF THE LUNG PARENCHYMA. THE AVERAGE LIFE EXPECTANCY FOR PATIENTS IS ONLY 3-5 YEARS, RESULTING IN THE DEATHS OF 40,000 PATIENTS EACH YEAR IN THE US. THERE ARE ONLY TWO FDA-APPROVED DRUGS FOR IPF THAT SLOW DISEASE PROGRESSION BUT DO NOT PREVENT OR REVERSE SYMPTOMS OR PATHOLOGY, AND THEY EXHIBIT SIGNIFICANT SIDE EFFECTS IN MANY PATIENTS. PROMISING DRUGS ARE IN DEVELOPMENT, BUT RECENT CLINICAL TRIAL FAILURES EMPHASIZE THE NEED FOR ADDITIONAL THERAPEUTIC APPROACHES. IPF BEGINS FOLLOWING AN INSULT TO THE TISSUE MICROENVIRONMENT, RESULTING IN A LOSS OF ALVEOLAR CELLS, GROWTH OF ACTIVATED FIBROBLASTS (MYOFIBROBLASTS), AND INCREASED DEPOSITION OF EXTRACELLULAR MATRIX PROTEINS, LIKE COLLAGEN, LEADING TO SCARRING, INCREASED TISSUE STIFFNESS, AND THE INABILITY TO BREATHE FOLLOWED BY DEATH. MANY CELL SIGNALING PATHWAYS CONTRIBUTE TO THIS PATHOLOGY, INCLUDING TGFΒ SIGNALING. A HIGH CONTENT IMAGING SCREEN WAS USED TO DISCOVER THAT THE FDA- APPROVED PINWORM DRUG PYRVINIUM (PYR) BLOCKS TGFΒ-INDUCED FIBROSIS. SUBSEQUENT STUDIES SHOWED PYR ACTIVATED CASEIN KINASE 1Α AND DOWNREGULATED THE YAP/TAZ SIGNALING PATHWAY. PYR APPEARED EFFICACIOUS IN A VARIETY OF IN VITRO ASSAYS AND IN VIVO STUDIES (INTRAPERITONEAL ROUTE), BUT BIOAVAILABILITY PROBLEMS PRESENTED A CHALLENGE FOR ORAL ADMINISTRATION. INHALATION DOSING ALLOWS FOR DIRECT DRUG DELIVERY TO THE SITE OF ACTION AND MAY REDUCE THE POSSIBILITY OF OFF-TARGET ORGAN TOXICITY. IN PRELIMINARY ACUTE TOXICITY STUDIES, PYR WAS WELL-TOLERATED WHEN ADMINISTERED AS A NEBULIZED AQUEOUS SOLUTION TO MICE, BUT EFFICACY WAS NOT TESTED. THEREFORE, THE FOLLOWING AIMS ARE PROPOSED TO FURTHER DEVELOP PYR AS AN EXPERIMENTAL IPF THERAPEUTIC DESIGNED FOR INHALED ADMINISTRATION. IN AIM 1, PYR WILL BE ADMINISTERED BY OROPHARYNGEAL ASPIRATION BEGINNING AFTER ADMINISTRATION OF BLEOMYCIN, A TREATMENT RESULTING IN PROGRESSIVE FIBROSIS OVER 3 MONTHS. A SECOND ANIMAL MODEL WILL INVOLVE ADMINISTRATION TO LUNGS OF AN ADENOVIRUS EXPRESSING TGFΒ TO INDUCE FIBROSIS. LUNGS WILL BE ANALYZED BY HISTOPATHOLOGICAL AND BIOCHEMICAL APPROACHES TO MEASURE EXTRACELLULAR MATRIX REMODELING, FIBROSIS, CELL PROLIFERATION AND MEASURES OF TOXICITY. THIS STUDY WILL DETERMINE IF PYR IS SAFE AND EFFECTIVE IN TWO RELEVANT MOUSE MODELS WHEN ADMINISTERED VIA INHALATION. AIM 2 WILL TEST THE ABILITY OF PYR TO REPRESS FIBROSIS IN EX VIVO HUMAN PRECISION-CUT LUNG SLICE TISSUE FROM HEALTHY AND IPF PATIENT DONORS. ASSAYS WILL INCLUDE A HYDROXYPROLINE ASSAY FOR COLLAGEN, IMMUNOBLOTTING, AND QRT-PCR ANALYSIS TO MEASURE ACTIVITY OF FIBROSIS-ASSOCIATED SIGNALING PATHWAYS, AUTOMATED IMAGING TO QUANTIFY ALVEOLAR AND FIBROBLAST CELL DENSITY, AND HISTOLOGICAL STAINING TO SCORE CHANGES IN CELL MORPHOLOGY AND TISSUE ARCHITECTURE. THIS STUDY WILL REVEAL IF PYR CAN INHIBIT AND REVERSE FIBROSIS IN A HUMAN EX VIVO MODEL, ADDING RELEVANCE TO OUTCOMES OF THE MOUSE STUDIES, AND WILL BE USED TO TEST THE PROPOSED MECHANISMS OF ACTION FOR PYR. THESE DATA WILL ALSO INFORM THE DESIGN OF IND-ENABLING SAFETY AND PHARMACOLOGY STUDIES IN PREPARATION FOR A PHASE 1 CLINICAL TRIAL.

STTR PHASE I: INTELLIGENT CONTROL SYSTEM FOR POLYMER INJECTION MOLDING -THE BROADER/COMMERCIAL IMPACT OF THIS SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PHASE I PROJECT IS THE DEVELOPMENT OF A SMART CONTROL SYSTEM THAT IMPROVES THE EFFICIENCY AND RELIABILITY OF PLASTIC INJECTION MOLDING, A PROCESS USED TO MANUFACTURE MILLIONS OF PARTS FOR MEDICAL DEVICES, AUTOMOBILES, AND CONSUMER GOODS. TODAY, MANUFACTURERS OFTEN RELY ON TRIAL-AND-ERROR METHODS THAT WASTE TIME, ENERGY, AND MATERIALS, AND MAKE IT DIFFICULT TO USE RECYCLED PLASTICS DUE TO THEIR VARIABILITY. THE SYSTEM CAN PREDICT IF A PART WILL MEET QUALITY STANDARDS BEFORE IT IS FINISHED AND CAN AUTOMATICALLY ADJUST MACHINE SETTINGS TO REDUCE MISTAKES. THIS SAVES ENERGY (12?15%), LOWERS SCRAP RATES, AND MAKES IT EASIER TO USE MORE RECYCLED MATERIALS WITHOUT LOSING QUALITY. THE TECHNOLOGY WILL FIRST HELP MEDICAL DEVICE COMPANIES REDUCE COSTLY PRODUCTION ERRORS AND SPEED UP APPROVALS, IMPROVING PATIENT SAFETY. IT WILL ALSO HELP AUTOMOTIVE AND CONSUMER PRODUCT COMPANIES MAKE STRONG, RELIABLE PRODUCTS WHILE USING MORE RECYCLED PLASTICS. BY CUTTING WASTE AND ENERGY USE, THIS SYSTEM SUPPORTS CLEANER MANUFACTURING AND HELPS U.S. COMPANIES STAY COMPETITIVE. THIS SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PHASE I PROJECT DEVELOPS AND VALIDATES A HYBRID (PHYSICS- AND ARTIFICIAL INTELLIGENCE-DRIVEN) CLOSED-LOOP CONTROL SYSTEM FOR INJECTION MOLDING. THE SYSTEM COMBINES REAL-TIME MULTIVARIATE IN-MOLD SENSING (PRESSURE, TEMPERATURE, SHRINKAGE) WITH MACHINE-STATE SIGNALS (INJECTION SPEED, HOLD PRESSURE, COOLING, SCREW ROTATION SPEED, SWITCHOVER POINTS) TO MODEL MELT-STATE DYNAMICS. THIS APPROACH INTEGRATES PHYSICS-BASED MODELS OF FLOW, VISCOELASTICITY, SHRINKAGE, SHEAR, AND CRYSTALLIZATION WITH GAUSSIAN PROCESS REGRESSION, PRINCIPAL COMPONENT ANALYSIS, PARTIAL LEAST SQUARES, AND AI-BASED ALGORITHMS TO ENABLE PART-QUALITY INFERENCE BEFORE EJECTION. PHASE I OBJECTIVES ARE: (1) DEMONSTRATE PREDICTIVE QUALITY CONTROL WITH DECISION CYCLES UNDER 500 MILLISECONDS, (2) OPTIMIZE CYCLE TIME THROUGH DYNAMIC CONTROL OF HOLD AND COOLING PHASES, (3) VALIDATE ROBUSTNESS WHEN MOLDING HIGH RECYCLED RESIN CONTENT (TARGETS: 70?80% POLYPROPYLENE, ~70% POLYETHYLENE) COMPARED TO VIRGIN RESINS, AND (4) ESTABLISH DATA INTEGRITY PROTOCOLS CONSISTENT WITH FDA 21 CFR PART 11 AND ISO 13485 STANDARDS. DATA COLLECTION WILL BE CONDUCTED AT THE UNIVERSITY OF MASSACHUSETTS LOWELL USING A PRE-INSTRUMENTED PRESS AND MOLDS. EXPECTED OUTCOMES INCLUDE PREDICTIVE MODELS WITH <5% ERROR ON QUALITY METRICS, ENERGY EFFICIENCY GAINS OF 12?15%, AND PROOF-OF-CONCEPT ADAPTIVE CONTROLS. THE RESULTS ADVANCE UNDERSTANDING OF POLYMER PROCESS DYNAMICS AND LAY THE FOUNDATION FOR PHASE II COMMERCIALIZATION. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

OTHER-TECH

ACCESS TO EDUCATION FOR PEOPLE WITH DISABILITIES IN THE PHILIPPINES PROJECT (AE-PWD)

LEON COUNTY COMMUNITY COALITION

SAINT LEO UNIVERSITY CAMPUS ADVOCACY RESOURCES AND EDUCATION PROGRAM (CARE)

STEM CAREERLAUNCH: EVALUATING THE FEASIBILITY OF A STEM CAREER-BASED, COLLECTIVE IMPACT MODEL ON YOUTH IN BOYS & GIRLS CLUBS

IMPROVE EXISTING AIRPORT

CONTINUUM OF CARE PROGRAM

SAINT LEO UNIVERSITY CAMPUS ADVOCACY RESOURCES AND EDUCATION PROGRAM (CARE)

FINANCIAL AID GRANTS TO STUDENTS, TO BE USED FOR ANY COMPONENT OF THE STUDENT'S COST OF ATTENDANCE OR FOR EMERGENCY COSTS DUE TO CORONAVIRUS, SUCH AS TUITION, FOOD, HOUSING, HEALTH CARE OR CHILDCARE

FIE EARMARK GRANT AWARDS

APPLICANT: PALEONTOLOGICAL RESEARCH INSTITUTION TITLE: A WATERSHED OF TREES: A MWEE TO ENGAGE STUDENTS AT THE INTERSECTION OF FOREST, WATER, CLIMATE, AND ENVIRONMENTAL STEWARDSHIP OVERVIEW: THE OVERARCHING GOAL OF THIS PROJECT IS TO GET CHILDREN OUTSIDE IN THEIR OWN COMMUNITY TO OBSERVE, RECORD, MONITOR, AND BUILD UNDERSTANDING OF THE IMPORTANCE OF WATER AND CLIMATE ON THE QUALITY OF LIFE IN THEIR COMMUNITIES, AND EMPOWER THEM TO ACT ON THAT UNDERSTANDING. THEY WILL DO THIS BY STUDYING THE IMPACT OF TREES ON THE MOVEMENT OF WATER THROUGH THE WATERSHED AND THE SUBSEQUENT CHANGES IN MICROCLIMATE AND WATER QUALITY THAT ARISE FROM WATER-VEGETATION INTERACTIONS. TREES HAVE BEEN CHOSEN AS THE CENTRAL PLAYER IN THIS PROPOSED DISTRICT-WIDE MWEE BECAUSE (1) THEY ARE PRESENT IN SCHOOLYARDS IN EACH OF THE DIVERSE ECOSYSTEMS THAT COMPRISE THE COUNTY, FROM URBAN TO AGRICULTURAL, (2) THE PRESENCE OR ABSENCE OF TREES PROFOUNDLY IMPACTS WATER MOVEMENT AND WATER QUALITY, WITH ADDITIONAL IMPACTS ON AM

SBIR PHASE I: HYPER-COMPACT NEUTRON GENERATOR FOR ADVANCED DETECTION -THIS SMALL BUSINESS INNOVATION RESEARCH PHASE I PROJECT AIMS TO TRANSFORM SPECTROSCOPY SYSTEMS THAT IDENTIFY MATERIALS BY DETECTING A SPECIFIC SIGNATURE OF GAMMA RADIATION. SUCH NONDESTRUCTIVE DETECTION TECHNOLOGY IS USED IN AGRICULTURE, MINING, DEFENSE, OIL AND GAS, BORDER SECURITY, AND OTHER INDUSTRIES. THE PROPOSED INNOVATION IS A NOVEL ULTRA-COMPACT NEUTRON GENERATOR, WHICH IS AN ESSENTIAL COMPONENT OF MATERIAL ANALYSIS SYSTEMS USED FOR A WIDE RANGE OF ELEMENTS. ADVANTAGES OF THE PROPOSED NEUTRON GENERATOR ARE ITS ULTRA-LOW SIZE, WEIGHT, AND POWER CONSUMPTION, WHICH WILL ENABLE PORTABLE DETECTION APPLICATIONS, REDUCE COSTS, AND GREATLY EXPAND THE POTENTIAL TO ADOPT THIS DETECTION TECHNOLOGY IN MORE APPLICATIONS AND ENABLE ITS USE IN TIGHT SPACES, SUCH AS ON BOARD SMALL AIRCRAFT OR SPACE VEHICLES. THE IMPROVED NEUTRON GENERATOR WILL SIGNIFICANTLY ENHANCE SECURITY BY IMPROVING DETECTION CAPABILITIES IN APPLICATIONS SUCH AS THE IDENTIFICATION OF EXPLOSIVES, HAZARDOUS CHEMICALS, AND SPECIAL NUCLEAR MATERIAL. IT WILL ALSO ENABLE WIDE-FIELD SURVEYS FOR AGRICULTURAL, NATURAL RESOURCE EXPLORATION, AND GEOLOGICAL APPLICATIONS. WITH THE NEUTRON-ACTIVATION ANALYSIS INDUSTRY VALUED AT OVER $100 MILLION DOMESTICALLY, THIS BREAKTHROUGH HAS THE POTENTIAL TO INCREASE THIS MARKET SIZE BY AT LEAST $14 MILLION. THUS, THE PROJECT PROMISES SUBSTANTIAL TECHNICAL, ECONOMIC, AND NATIONAL SECURITY BENEFITS. THE INTELLECTUAL MERIT OF THIS PROJECT LIES IN ITS INNOVATIVE USE OF LITHIUM NIOBATE PIEZOELECTRIC TRANSFORMERS (PTS) ARRANGED IN A NOVEL ANTIPHASE CONFIGURATION TO ACCELERATE DEUTERIUM AND TRITIUM ATOMS FOR A NUCLEAR FUSION-BASED NEUTRON GENERATOR. THIS APPROACH USES RESONANCE DRIVE TECHNOLOGY TO LEVERAGE THE HIGH GAIN OF THE PTS AND ACHIEVE ACCELERATION POTENTIALS THAT MAXIMIZE THE FUSION REACTION RATE WITHOUT MAGNETIC OR VOLTAGE MULTIPLIER COMPONENTS. FURTHERMORE, THE UNIQUE IN-VACUUM OPERATION ELIMINATES THE BULKY AND EXPENSIVE HIGH-VOLTAGE HERMETIC FEEDTHROUGHS. THIS RESULTING NEUTRON GENERATOR WILL PRODUCE 300 MILLION NEUTRONS PER SECOND WITH A WEIGHT OF UNDER 5 POUNDS, A POWER DRAW OF LESS THAN 10 WATTS, AND A VOLUME OF LESS THAN 90 CUBIC INCHES. THE RESEARCH OBJECTIVES OF THIS PROJECT ARE TO DEVELOP AN IN-VACUUM MOUNTING STRATEGY TO ENABLE THE HIGH GAIN OF THE PT, DEVELOP ANTIPHASE RESONANCE DRIVE CIRCUITRY, DEVELOP A TARGET AND ION SOURCE THAT ARE INTEGRAL TO THE PTS, AND DESIGN A FIELD-FORMING GEOMETRY FOR THE VACUUM CHAMBER. COMBINED, THESE ADVANCEMENTS WILL RESULT IN A NEUTRON GENERATOR THAT SURPASSES THE PERFORMANCE OF EXISTING SYSTEMS, IN MULTIPLE METRICS, BY MORE THAN AN ORDER OF MAGNITUDE, MARKING A SIGNIFICANT LEAP IN NEUTRON GENERATOR TECHNOLOGY. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.