Trinity College

CARES ACT INSTITUTIONAL RELIEF

COVID-19 PANDEMIC RELIEF GRANTS FOR STUDENTS

THE ROLE OF ADENOSINE IN KETOGENIC DIET THERAPY

TRINITY COLLEGE: CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND (SECOND SUBMISSION)

TRINITY COLLEGE: CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND

PREDOMINANTLY BLACK INSTITUTIONS PROGRAM - FORMULA GRANTS

CS 10K: MOBILE CSP: USING MOBILE LEARNING TO TEACH CS PRINCIPLES IN CONNECTICUT SCHOOLS

HIGHER EDUCATION EMERGENCY RELIEF FOR MINORITY SERVING INSTITUTION

UPWARD BOUND PROGRAM

METABOLIC THERAPY TO RELIEVE PAIN: KETOGENIC DIET AND ADENOSINE

NEUROINFLAMMATORY AND COGNITIVE CONSEQUENCES OF LOSING CHOLINERGIC ANTI-INFLAMMATORY TONE IN THE FOREBRAIN

PREDOMINANTLY BLACK INSTITUTIONS PROGRAM - FORMULA GRANTS

ALS RISK IN LATIN AMERICANS- A POPULATION BASED CASE CONTROL COMPARATIVE STUDY WITH 3 EUROPEAN POPULATION BASED COHORTS.

6/7 PSYCHIATRIC GENOMICS CONSORTIUM: ADVANCING DISCOVERY AND IMPACT - PROJECT SUMMARY NOW IN ITS 13TH YEAR, THE PSYCHIATRIC GENOMICS CONSORTIUM IS PERHAPS THE MOST INNOVATIVE AND PRODUCTIVE EXPERIMENT IN THE HISTORY OF PSYCHIATRY. THE PGC UNIFIED THE FIELD AND ATTRACTED A CADRE OF OUTSTANDING SCIENTISTS (802 INVESTIGATORS FROM 157 INSTITUTIONS IN 41 COUNTRIES). PGC WORK HAS LED TO IDENTIFICATION OF ~500 GENETIC LOCI IN THE 11 PSYCHIATRIC DISORDERS WE STUDY. OUR WORK HAS LED TO 320 PAPERS, MANY IN HIGH-PROFILE JOURNALS (NATURE 3, CELL 5, SCIENCE 2, NAT GENET 27, NAT NEUROSCI 9, MOL PSYCH 37, BIOL PSYCH 25). AS SUMMARY STATISTICS ARE FREELY AVAILABLE, PSYCHIATRIC DISORDERS OFTEN FEATURE PROMINENTLY IN PAPERS BY NON-PGC INVESTIGATORS. TO ADVANCE DISCOVERY AND IMPACT, WE PROPOSE TO CONTINUE THE WORK OF THE PGC ACROSS 11 DISORDER GROUPS. CONSIDERABLE NEW DATA ARE COMING IN THE NEXT FIVE YEARS. WE THUS CAN RAPIDLY AND EFFICIENTLY INCREASE OUR KNOWLEDGE OF THE FUNDAMENTAL BASIS OF MAJOR PSYCHIATRIC DISORDERS. AIM 1: WE WILL CONTINUE TO ADVANCE GENETIC DISCOVERY FOR SEVERE PSYCHIATRIC DISORDERS IN ALL WORKING GROUPS, SYSTEMATICALLY INTERFACE WITH LARGE BIOBANK STUDIES TO ENSURE MAXIMAL COMPARABILITY, AND AGGRESSIVELY PROMOTE NEW STUDIES OF INDIVIDUALS WITH PSYCHIATRIC DISORDERS FROM DIVERSE ANCESTRIES TO INCREASE DISCOVERY AND IMPROVE FINE-MAPPING. AIM 2: MOST STUDIES ANALYZE COMMON VARIATION (AIM 1), RARE CNV (AIM 2), AND RARE EXOME/GENOME RESEQUENCING RESULTS (VIA COLLABORATION) IN ISOLATION: WE WILL APPLY AN INTEGRATIVE FRAMEWORK TO RIGOROUSLY EVALUATE THE CONTRIBUTIONS OF ALL MEASURED TYPES OF GENETIC VARIATION ON RISK FOR PSYCHIATRIC DISORDERS. AIM 3: WE WILL MOVE BEYOND CLASSICAL CASE-CONTROL DEFINITIONS TO A MORE BIOLOGICALLY-BASED AND NUANCED UNDERSTANDING BY ENABLING LARGE TRANS-DIAGNOSTIC STUDIES, CONVENE TRANS-DISCIPLINARY TEAMS TO USE GENETICS TO ADDRESS UNRESOLVED QUESTIONS ABOUT THE NATURE OF PSYCHIATRIC DISORDERS, AND TO PROMOTE LARGE STUDIES OF THE SEVEREST CASES SEEN IN PSYCHIATRIC PRACTICE (LEVERAGING THE GLOBAL REACH OF PGC INVESTIGATORS). AIM 4: WE WILL WORK TO MAXIMIZE THE IMPACT OF OUR WORK VIA TRANSLATIONAL EFFORTS: CLOSE COLLABORATIONS WITH NEUROSCIENCE CONSORTIA TO UNDERSTAND THE BIOLOGICAL IMPLICATIONS OF OUR FINDINGS; WORK TO IDENTIFY MODIFIABLE CAUSAL RISK FACTORS; AND WORK TO ROBUSTLY PREDICT CLINICAL OUTCOMES AND IDENTIFY PATIENT SUBSETS. AIM 5: WE WILL INCREASE IMPACT OF OUR WORK BY EXTENDING AND FORMALIZING OUTREACH TO DIFFERENT COMMUNITIES (INCLUDING PHARMA AND BIOTECH), VIA DIGITAL MEDIA (TWITTER, FACEBOOK, WIKIPEDIA), AND BY DEVELOPING, DISTRIBUTING, AND UPDATING RESOURCES/EDUCATIONAL MATERIAL FOR PATIENTS, FAMILIES, AND MEDICAL PROFESSIONALS. WE WILL CONVENE A SCIENTIFIC ADVISORY BOARD TO ENSURE WE RESPOND POSITIVELY TO THOSE INVESTED IN OUR RESULTS SUCCESSFUL COMPLETION OF THIS BODY OF WORK WILL GREATLY ADVANCE KNOWLEDGE OF THE GENETIC BASIS OF PSYCHIATRIC DISORDERS WITH POTENTIALLY MAJOR NOSOLOGICAL AND TREATMENT IMPLICATIONS. THESE GOALS ARE CONSISTENT WITH A CORE MISSION OF THE NIMH, AND THE CENTRAL IDEA OF THE PGC: TO CONVERT THE FAMILY HISTORY RISK FACTOR INTO BIOLOGICALLY, CLINICALLY, AND THERAPEUTICALLY MEANINGFUL INSIGHTS.

COLD ENGRAMS AT THE INTERFACE OF MEMORY AND METABOLISM

RENOVATION OF CHEMISTRY RESEARCH LABORATORIES AT TRINITY COLLEGE

CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND- IHES (CFDA: 84:425F)

COLLABORATIVE RESEARCH: RUI: REGULATING THE TRIBOLIUM SEGMENTATION CLOCK

INNATE MEMORY - THE PLASTICITY OF INSTINCT

EFFECTS OF A KETOGENIC DIET ON REGIONAL BRAIN ENERGY AND PLASTICITY

6/7 PSYCHIATRIC GENOMICS CONSORTIUM FINDING ACTIONABLE VARIATION

RISK AND PROTECTIVE FACTORS FOR PSYCHOSOCIAL RESILIENCE IN SPOUSAL CAREGIVERS FOR SPOUSES WITH COGNITIVE DECLINE - ABSTRACT FAMILY CARING PLAYS AN ESSENTIAL ROLE IN SUSTAINING HEALTH SYSTEMS, BUT CAN PLACE SOCIAL, FINANCIAL, PHYSICAL, AND EMOTIONAL DEMANDS ON CARERS. UNDERSTANDING WHAT CAREGIVERS NEED TO SUPPORT THEM IS KEY TO FACILITATING FAMILY CARE. SPOUSAL CARERS FOR SPOUSES WITH ALZHEIMER’S AND ALZHEIMER’S-RELATED DEMENTIA (AD/ADRD) ARE PARTICULARLY SUBJECT TO ADDITIONAL STRESS AND BURDEN. WHY SOME CARERS SEEM TO MANAGE THEIR LONG-TERM WELL-BEING BETTER THAN OTHERS IS LESS UNDERSTOOD. DIFFERENCES IN WELL-BEING OBSERVED BETWEEN CAREGIVERS MAY BE AN INDICATOR OF HOW THEY DIFFER IN ADAPTING TO CHANGING CIRCUMSTANCES AND THEIR ABILITY TO MAINTAIN OR RECOVER THEIR MENTAL HEALTH AND WELL-BEING FOLLOWING AN ADVERSE EVENT (PSYCHOSOCIAL RESILIENCE). THIS STUDY LEVERAGES DATA FROM INTERNATIONAL HARMONIZED COGNITIVE ASSESSMENT PROTOCOL (HCAP) STUDIES AND LONGITUDINAL DATA FROM THE HEALTH AND RETIREMENT STUDY (HRS) FRAMEWORK OF BIENNIAL AGING COHORT STUDIES. THE HRS (15 WAVES), THE IRISH LONGITUDINAL STUDY ON AGEING (TILDA) (6 WAVES), THE ENGLISH LONGITUDINAL STUDY OF AGEING (ELSA) (9 WAVES) AND THE SURVEY OF HEALTH, AGEING AND RETIREMENT IN EUROPE (SHARE) (8 WAVES) ARE LARGE, NATIONALLY REPRESENTATIVE, PROSPECTIVE COHORT STUDIES THAT EXAMINE THE SOCIAL, ECONOMIC AND HEALTH CIRCUMSTANCES OF COMMUNITY-DWELLING ADULTS AGED ≥50 YEARS FROM WHICH SPOUSAL CARER- DYADS CAN BE DRAWN. COGNITIVE ASSESSMENTS ARE AVAILABLE FROM HCAP AND DETAILED MEASUREMENTS OF WELL- BEING AND MENTAL HEALTH AND COGNITION FROM THE INDIVIDUAL LONGITUDINAL COHORT STUDIES (INCLUDING MEASURES OF DEPRESSIVE SYMPTOMS, QUALITY OF LIFE AND LIFE SATISFACTION), IN ADDITION TO WELL-CHARACTERIZED SOCIAL, ECONOMIC AND HEALTH DATA, FORMAL CARE PROVISION, AND POLICY CONTEXT. THIS STUDY AIMS TO: (1) IDENTIFY CHANGES OVER TIME IN PSYCHOSOCIAL RESILIENCE IN MENTAL HEALTH AND WELL-BEING, AND COGNITIVE HEALTH IN SPOUSAL CAREGIVERS FOR SPOUSES WITH NORMAL COGNITION/AD/ARD; (2) DETERMINE THE RISK AND PROTECTIVE FACTORS ASSOCIATED WITH RESILIENT GROUPS AND INVESTIGATE WHAT ROLE SOCIETAL AND POLICY CONTEXTS PLAY IN SHAPING THESE TRAJECTORIES; (3) INVESTIGATE HOW THE NEEDS OF BOTH THE CAREGIVER AND THE CARE RECIPIENT INFLUENCE PSYCHOSOCIAL RESILIENCE. TO ADDRESS THESE AIMS, MULTIPLE WAVES OF HRS FRAMEWORK SURVEY DATA COMBINED WITH HCAP DATA WILL BE INVESTIGATED AND ADVANCED LONGITUDINAL STATISTICAL TECHNIQUES (GROWTH MIXTURE MODELS, MULTILEVEL ANALYSIS AND ACTOR-PARTNER INTERDEPENDENCE MODELS) WILL BE APPLIED. GIVEN THE COMPLEX NATURE OF THIS STUDY, WE HAVE ASSEMBLED AN OUTSTANDING MULTI-DISCIPLINARY TEAM OF CLINICAL AND ACADEMIC RESEARCHERS WITH EXPERTISE IN EACH OF THE CONSTITUENT PARTS OF THE PROJECT. STUDY RESULTS WILL IDENTIFY IMPORTANT RISK AND PROTECTIVE FACTORS FOR PSYCHOSOCIAL RESILIENCE IN CARER-DYADS THAT ARE AMENABLE TO INTERVENTION. IN DOING SO, THE STUDY WILL INFORM THE PRIORITIES FOR SOCIAL AND COMMUNITY-LEVEL SERVICES AND SUPPORTS FOR SPOUSAL CAREGIVERS TO ENHANCE RESILIENCE AND MAINTAIN COGNITION IN BOTH CAREGIVERS AND THEIR SPOUSES, AS WELL AS AID IN THE DESIGN OF NEW POLICIES AND PROGRAMS TO MEET THESE NEEDS.

CARES ACT: HIGHER EDUCATION EMERGENCY RELIEF FUND

PREVENTING PRESCRIPTION STIMULANT DIVERSION AND MEDICATION MISUSE VIA A WEB-BASED SIMULATION INTERVENTION

CPATH-2: COLLABORATIVE RESEARCH: BUILDING A COMMUNITY TO INCORPORATE HUMANITARIAN FREE AND OPEN SOURCE SOFTWARE INTO UNDERGRADUATE COMPUTING EDUCATIO

COLLABORATIVE RESEARCH: RUI: ADDING SEGMENTS ONE BY ONE: A COMPARATIVE ANALYSIS OF THE GROWTH ZONE IN ARTHROPODS

RUI: PHYSIOLOGICAL REGULATION OF ATP AND ADENOSINE: LINKING METABOLISM TO NEURONAL EXCITABILITY

ICOB:COLLABORATIVE RESEARCH:RUI: GENERATING COMPLEXITY: INTEGRATING EXPERIMENTAL AND COMPUTER MODELING APPROACHES TO LINK GENES AND CELL BEHAVIOR IN

FUNDING WILL BE USED TO COVER THE INSTITUTIONS EXPENSES RELATED TO THE DISRUPTION OF CAMPUS OPERATIONS DUE TO CORONAVIRUS.

CAREER: REWARD LEARNING, SELECTION HISTORY, AND ATTENTIONAL CONTROL -FROM A PARADE OF INTERNAL THOUGHTS, FEELINGS, AND MEMORIES, TO AN EVER-CHANGING BARRAGE OF EXTERNAL SIGHTS, SOUNDS, AND SMELLS, WAKING LIFE CONTAINS FAR MORE INFORMATION THAN OUR NERVOUS SYSTEMS CAN HANDLE AT ANY ONE TIME. WE OVERCOME THIS CHALLENGE BY SELECTIVELY ATTENDING TO THE WORLD; THAT IS, BY PRIORITIZING THE PROCESSING OF SOME KINDS OF INFORMATION AT THE EXPENSE OF OTHERS. BUT HOW IS ATTENTION ALLOCATED AND HOW MUCH VOLUNTARY CONTROL DO WE HAVE OVER THAT PROCESS? THE ANSWERS TO THESE RESEARCH QUESTIONS HAVE VAST IMPLICATIONS FOR INDIVIDUAL EXPERIENCE, AND FOR SOCIETY AT LARGE. THIS FACULTY EARLY CAREER DEVELOPMENT (CAREER) PROJECT ADVANCES OUR SCIENTIFIC UNDERSTANDING OF HOW AN OBSERVER?S PAST MODULATES THEIR ATTENTION IN THE PRESENT. IN ADDITION TO INFORMING RESEARCH IN OTHER CORE AREAS OF PSYCHOLOGY LIKE LEARNING AND MEMORY, THE RESEARCH OUTCOMES HAVE APPLICATIONS TO CLINICAL WORK, AS ABERRANT ATTENTIONAL MECHANISMS ARE HYPOTHESIZED TO PLAY A ROLE IN A MULTITUDE OF MENTAL HEALTH DISORDERS (E.G., SUBSTANCE ABUSE, ANXIETY DISORDERS, AUTISM SPECTRUM DISORDER). THE PI IS A FACULTY MEMBER AT A PRIMARILY UNDERGRADUATE INSTITUTION, AND THIS PROJECT PROVIDES UNIQUE OPPORTUNITIES FOR UNDERGRADUATE RESEARCH TRAINING AND FOR STEM-FOCUSED INNOVATION IN THE UNDERGRADUATE CLASSROOM. AS AN ADDITIONAL COMPONENT OF THE EDUCATION PLAN, THE PI FURTHERS EFFORTS TO RAISE THE VISIBILITY OF ESTABLISHED SCIENTISTS FROM UNDERREPRESENTED COMMUNITIES AND PROMOTES INCLUSIVE MENTORING IN THE SERVICE OF RETAINING UNDERREPRESENTED STUDENTS IN SCIENCE. VISUAL ATTENTION CAN BE ALLOCATED TO SPECIFIC LOCATIONS IN THE VISUAL FIELD OR TO FEATURES OF OBJECTS LIKE COLOR, ORIENTATION, OR MOTION DIRECTION. SOMETIMES, SHIFTS OF ATTENTION ARE VOLUNTARILY GENERATED TO SUPPORT GOAL-DIRECTED BEHAVIOR. OTHER TIMES, ATTENTION IS ?CAPTURED? BY PHYSICALLY SALIENT OBJECTS (E.G., THOSE THAT SUDDENLY APPEAR OR ARE VISUALLY UNIQUE). WHILE FRAMING ATTENTION IN SUCH DICHOTOMOUS TERMS HAS BEEN THE DOMINANT THEORETICAL APPROACH FOR MANY DECADES, THE LITERATURE NOW MAKES CLEAR THAT NON-SALIENT STIMULI CAN ALSO CAPTURE ATTENTION. SUCH ATTENTIONAL BIASES RELY ON ONE?S UNIQUE HISTORY (E.G., IF OBJECTS HAVE BEEN FREQUENTLY ATTENDED IN THE PAST, OR IF THEY HAVE BEEN ASSOCIATED WITH RECEIVING REWARD). USING BEHAVIORAL AND EYE-TRACKING METHODS, THE FIRST RESEARCH GOAL OF THIS CAREER PROJECT IS TO DISENTANGLE THE IMPACT OF TWO SUCH HISTORICAL FACTORS ON ATTENTIONAL CONTROL: FREQUENT ATTENTIONAL ALLOCATION (SELECTION HISTORY) AND RECEIVING OF REWARDS (REWARD HISTORY). THE SECOND GOAL IS TO USE FUNCTIONAL BRAIN IMAGING TO EXAMINE THE NEURAL SYSTEMS INVOLVED IN SELECTION-HISTORY-DERIVED ATTENTIONAL BIASES AND TO TEST THE HYPOTHESIS THAT INFORMATION PREDICTION ERRORS GENERATED BY THE VENTRAL STRIATUM MODULATE THE ALLOCATION OF VISUAL ATTENTION. WHEREAS AIMS 1 AND 2 OF THE PROJECT FOCUS ON PHYSICALLY NON-SALIENT FEATURES THAT BIAS ATTENTION AS A RESULT OF FORMER EXPERIENCE, AIM 3 SHIFTS THE FOCUS TO PHYSICALLY SALIENT STIMULI AND EXAMINES HOW SALIENCY AND HISTORY INTERACT. EXTENDING RECENT WORK FROM THE PI?S LABORATORY, THE THIRD GOAL IS TO USE PSYCHOPHYSICAL METHODS TO MODEL THE TEMPORAL DYNAMICS OF VISUAL PROCESSING WHEN ATTENTION HAS BEEN REFLEXIVELY ALLOCATED BY ABRUPT ONSETS THAT PREDICT THE PRESENCE OR ABSENCE OF AVAILABLE REWARD. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

COLLABORATIVE RESEARCH: RUI: CONVERGENT EXTENSION IN A DYNAMICALLY PATTERNED EPITHELIUM

LOAN GRANT WITH FUNDS FOR NEW BUDGET PERIOD

KATP: DYNAMICS OF A CHANNEL-ENZYME COMPLEX - PROJECT SUMMARY ATP-SENSITIVE K+ CHANNELS (KATP) COUPLE A CELL’S METABOLIC STATE TO ITS ELECTRICAL EXCITABILITY. THIS PROCESS IS CRUCIAL IN PANCREATIC Β-CELLS WHERE KATP COUPLES GLUCOSE UPTAKE TO INSULIN SECRETION. IN THE HEART, KATP PLAYS A PROTECTIVE ROLE, OPENING DURING HYPOXIA. THE ROLE OF THESE CHANNELS IS SO VITAL THAT KATP DYSFUNCTION IS ASSOCIATED WITH DISEASES OF INSULIN SECRETION, WITH SEVERE MUTATIONS CAUSING TREATMENT-RESISTANT SYNDROMES WITH ACCOMPANYING NEUROLOGICAL DEFICITS. TO STUDY THIS CRITICAL CHANNEL, WE DEVELOPED SPECTROSCOPIC TOOLS THAT ALLOW US TO SIMULTANEOUSLY PROBE KATP STRUCTURE AND FUNCTION. THIS IS AN IDEAL APPROACH FOR UNDERSTANDING KATP’S PHYSIOLOGICAL ROLE AND PROBING LONG-STANDING QUESTIONS OF BIOCHEMISTRY. HOW IS THE INPUT OF ENERGY FROM LIGAND BINDING COUPLED TO CHANGES IN PROTEIN FUNCTION? HOW CAN ONE MECHANISTICALLY SEPARATE LIGAND BINDING FROM PROTEIN ACTIVATION? HOW IS LONG-RANGE COMMUNICATION ACHIEVED BETWEEN SUBUNITS IN A MULTI-PROTEIN COMPLEX? KATP COMPRISES FOUR PORE-FORMING INWARD-RECTIFIER K+ CHANNEL SUBUNITS (KIR), EACH ASSOCIATED WITH A SULFONYLUREA RECEPTOR (SUR). THE CONNECTION BETWEEN KATP AND METABOLISM IS ESTABLISHED BY ATP/ADP BINDING TO THREE CLASSES OF NUCLEOTIDE BINDING SITE (NBS). BINDING TO KIR SHUTS KATP; BINDING TO TWO SITES ON SUR OPENS KATP. THUS, CHANNEL ACTIVITY IS A FUNCTION OF THE OCCUPANCY OF EACH NBS AND THEIR RELATIVE ENERGETIC CONTRIBUTION TO GATING. WE HAVE TAKEN A NOVEL APPROACH TO UNDERSTANDING THE ROLE OF EACH NBS IN KATP GATING: MEASURING SITE-SPECIFIC BINDING USING FÖRSTER RESONANCE ENERGY TRANSFER (FRET) BETWEEN FLUORESCENT ATP DERIVATIVES AND CHANNELS TAGGED WITH FLUORESCENT, NON-CANONICAL AMINO ACIDS. SIMULTANEOUS RECORDINGS OF BINDING AND IONIC CURRENT ALLOW US TO MODEL EACH NBS IN TERMS OF ITS NUCLEOTIDE AFFINITY AND ENERGETIC INFLUENCE ON GATING. THIS EXPERIMENTAL/ANALYTICAL FRAMEWORK WILL BE APPLIED TO EXAMINE THE DIFFERENCE BETWEEN HEART AND PANCREATIC KATP SUBTYPES AND THE CONSEQUENCES OF KATP MUTATIONS ASSOCIATED WITH DIABETES. WE WILL ASSESS THE ENZYMATIC ACTIVITY OF SUR (AN ATPASE) WITH MUTATIONS IN PUTATIVE CATALYTIC AMINO ACIDS AND NOVEL FLUORESCENT NON-HYDROLYZABLE ATP DERIVATIVES SYNTHESIZED IN HOUSE. FINALLY, WE WILL PROBE THE STRUCTURAL BASIS OF COUPLING BETWEEN THE KIR AND SUR SUBUNITS USING AN ENHANCED FRET TECHNIQUE IN WHICH COLORED METAL IONS ARE USED AS SHORT-DISTANCE FLUORESCENCE QUENCHERS. THESE COMBINED APPROACHES WILL YIELD A NEW APPRECIATION FOR THE PHYSIOLOGICAL ROLE OF KATP AND ITS DYSFUNCTION IN CERTAIN FORMS OF DIABETES. NOVEL INSIGHTS INTO THE ENERGETICS AND CONFORMATIONAL DYNAMICS OF KATP WILL PROVIDE A TEMPLATE FOR UNDERSTANDING THE BEHAVIOR OF OTHER PROTEIN COMPLEXES.

CPATH CB: COLLABORATIVE: CAN HUMANITARIAN OPEN-SOURCE SOFTWARE DEVELOPMENT HELP REVITALIZE UNDERGRADUATE COMPUTING EDUCATION?

FUNDING WILL BE USED TO COVER EXPENSES RELATED TO THE DISRUPTION OF CAMPUS OPERATIONS DUE TO CORONAVIRUS.

FUNDING WILL BE USED TO COVER EXPENSES RELATED TO THE DISRUPTION OF CAMPUS OPERATIONS DUE TO CORONAVIRUS (INCLUDING ELIGIBLE EXPENSES UNDER A STUDENT'S COST OF ATTENDANCE, SUCH AS FOOD, HOUSING, ETC.)

MRI: ACQUISITION OF AN ANALYTICAL SCANNING ELECTRON MICROSCOPE FOR AN INTERDISCIPLINARY MULTI-USER FACILITY

CC*DNI CAMPUS DESIGN:TRINITY COLLEGE NEXT GENERATION SCIENCE NETWORK AND DMZ

COLLABORATIVE RESEARCH: SATC: CORE: MEDIUM: RUI: APPLIED CRYPTOGRAPHIC PROTOCOLS WITH PROVABLY-SECURE FOUNDATIONS -CRYPTOGRAPHIC PROTOCOLS HAVE BECOME AN ESSENTIAL FACILITATOR FOR THE INTERNET AND ITS MANY APPLICATIONS, SUPPORTING THE NEEDS OF MODERN SOCIETY. IT IS HARD TO IMAGINE THE INTERNET WITHOUT THE EXTENSIVE USE OF APPLIED CRYPTOGRAPHIC PROTOCOLS, E.G., PROTOCOLS USED TO SECURE WEB AND EMAIL. SUCH PROTOCOLS USE AND DEPEND ON THE PUBLIC KEY INFRASTRUCTURE (PKI), WHICH IS ALSO KEY TO THE SECURITY OF OTHER OPEN SYSTEMS SUCH AS MOBILE NETWORKS, INTERNET OF THINGS, AND BLOCKCHAINS. PKI PROVIDES A CRITICAL SECURITY INFRASTRUCTURE TO ACHIEVE CONFIDENTIALITY, AUTHENTICATION, INTEGRITY AND NON-REPUDIATION. HOWEVER, THERE HAVE BEEN MANY ATTACKS EXPLOITING VULNERABILITIES OF THE PKI ITSELF; PKI, IN CONTRAST TO OTHER WELL-KNOWN CRYPTOGRAPHIC PROTOCOLS, HAS NO SECURITY PROOFS OR EVEN PRECISE DEFINITIONS OF SECURITY GOALS. AS A RESULT, SYSTEMS UTILIZING PKI MAY BE VULNERABLE. THE PROPOSED RESEARCH WILL DEFINE SECURITY GOALS FOR PKI SCHEMES, PRESENT PKI SCHEMES WHICH PROVABLY MEET THESE GOALS, AND PRESENT PRACTICAL AND EFFICIENT IMPLEMENTATIONS OF PKI SCHEMES. THIS RESEARCH WILL ALSO DEVELOP THE NECESSARY THEORETICAL TOOLS TO DEFINE SECURITY GOALS OF CRYPTOGRAPHIC PROTOCOLS AND TO ANALYZE THEIR SECURITY. THE OUTCOMES OF THIS RESEARCH WILL HAVE BROAD BENEFITS. DEVELOPERS WILL BENEFIT FROM THE AVAILABILITY OF OPEN-SOURCE, PROVABLY SECURE PKI SYSTEMS, ENABLING SECURITY FOR REAL-WORLD APPLICATIONS. END-USERS WILL BENEFIT FROM IMPROVED SECURITY GUARANTEES AND PRIVACY. GIVEN THE GLOBAL ROLE OF THE INTERNET, SOCIETY AT LARGE WILL BENEFIT FROM A STRENGTHENED, ADVANCED SECURITY INFRASTRUCTURE AND PKI ECOSYSTEM AND FROM EDUCATIONAL EFFORTS WHICH WILL RAISE AWARENESS OF THE IMPORTANCE OF THESE TOPICS. FURTHERMORE, THIS RESEARCH WILL SUPPORT THE DEVELOPMENT OF A DIVERSE COHORT OF GRADUATE AND UNDERGRADUATE STUDENTS AT THE UNIVERSITY OF CONNECTICUT AND TRINITY COLLEGE THROUGH INCREASED RESEARCH OPPORTUNITIES, EDUCATION, AND MENTORING AND OUTREACH EFFORTS. RESEARCH EFFORTS OF THIS PROJECT, THE RESULTS OF WHICH WILL SIGNIFICANTLY IMPACT THE THEORETICAL AND PRACTICAL ASPECTS OF DEVELOPING AND DEPLOYING CRYPTOGRAPHIC PROTOCOLS, ARE ORGANIZED IN THREE MAIN AREAS: 1) ADVANCEMENT OF PKI THEORY: TO DEFINE A COMPREHENSIVE SET OF FORMAL PKI REQUIREMENTS, AND TO DESIGN AND ANALYZE SCHEMES TO PRODUCE PROVABLY SECURE PKI SCHEMES; 2) DEVELOPMENT OF PKI SYSTEMS WITH IMPROVED SECURITY GUARANTEES: TO DESIGN, DEVELOP, AND STANDARDIZE PROVABLY SECURE PKI DESIGNS THAT ARE PRACTICAL AND APPROPRIATE FOR REAL-WORLD APPLICATIONS; 3) DEVELOPMENT OF A FRAMEWORK AND TOOLS TO FACILITATE PROVABLE SECURITY FOR APPLIED CRYPTOGRAPHIC PROTOCOLS UNDER REALISTIC MODELS: TO BUILD A COMPREHENSIVE FRAMEWORK THAT SUPPORTS COMPOSABILITY AND FORMAL VERIFICATION TOOLS FOR RIGOROUS SPECIFICATION AND ANALYSIS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

RUI: CHARACTERIZATION OF NOTCH CIS-INHIBITORY SEQUENCES IN THE SERRATE LIGAND OF DROSOPHILA MELANOGASTER

TRADITIONAL: 36 MONTHS, FOREIGN ** FAADC MIGRATION NOTE - ACTION TYPE:"1" TO "A", ASSISTANCE TYPE:"4" TO "04", RECORD TYPE:"2", BUSINESS FUNDS INDICATOR:"NON", INDIVIDUAL RECIPIENT INDICATOR:"NO", RESEARCH AND DEVELOPMENT FUNDS INDICATOR:"YES", COMPETED OPPORTUNITY:"1" TO "C", NUMBER OF PROPOSALS OR APPLICATIONS:"1", AWARDING SUB-TIER AGENCY CODE "5700" DERIVED FROM AWARDING OFFICE CODE "FA9550", FUNDING SUB-TIER AGENCY CODE "5700" DERIVED FROM FUNDING OFFICE CODE "F3BB00", PPOP COUNTRY CODE:"IRL", PPOP FOREIGN LOCATION DESCRIPTION SET TO PPOP COUNTRY NAME "IRELAND", SMALL BUSINESS INDICATOR:"O", SAM EXCEPTION:"X" **

TCF MAY USE THE FUNDS TO DEFRAY EXPENSES INCURRED BY RECIPIENT, INCLUDING LOST REVENUE, REIMBURSEMENT FOR EXPENSES ALREADY INCURRED,TECHNOLOGY COSTS WITH TRANSITION TO DISTANCE EDUCATION.

RUI: MICROELECTROPHORETIC AND STATISTICAL TOOLS FOR STUDIES OF KINASE- AND ROS-BASED SIGNALING IN DICTYOSTELIUM DISCOIDEUM

THE MODULATION OF ADENOSINE BY TEMPERATURE, OXYGEN AND GLUCOSE

DEFENSE SECURITY COOPERATION UNIVERSITY RESEARCH GRANTS: EXPERIMENTAL ASSESSMENT OF SECURITY COOPERATION, MILITARY BEHAVIOR, AND PUBLIC TRUST IN CIVIL-MILITARY INSTITUTIONS AND SUPPLIERS

RUI: INVESTIGATIONS OF A NOVEL, BIMETALLIC RING SYSTEM FOR NUCLEATING BETA-SHEETS

THE EFFECTS OF KETOGENIC DIETS ON INFLAMMATION AND CHRONIC PAIN

RUI: SUBSTRATE REPORTERS AND MICROELECTROPHORETIC TOOLS FOR LYSATE AND SINGLE-CELL STUDIES OF PKB ACTIVITY IN DICTYOSTELIUM DISCOIDEUM

RUI: OPTICAL STUDIES OF PSEUDOELASTIC NANOPARTICLE DEFORMATION

COLLABORATIVE RESEARCH: REACTING TO THE PAST PEDAGOGY FOR SCIENCE EDUCATION

COLLABORATIVE RESEARCH: AGRICULTURAL ANTIBIOTICS AND HUMAN HEALTH: A MULTI-SCALE ECOLOGICAL APPROACH TO THE DEVELOPMENT AND SPREAD OF ANTIBIOTIC RESI

NICOP - REAL-TIME PRECISION PROPAGATION MODELING FOR MOBILE AD-HOC NETWORKS AND COGNITIVE RADIO VIA RADIO TOMOGRAPHIC IMAGING

CHP

TAS::57 3600::TAS "DETECTION AND CHARACTERIZATION OF THE PHOTOSPHERIC AND CORONAL MAGNETIC FIELDS OF SUNSPOT GROUPS IMPLICATIONS FOR FLARE FORECASTIN

MRI: ACQUISITION OF LABORATORY EQUIPMENT TO CHARACTERIZE SEDIMENTS AND SOILS FOR PALEOENVIRONMENTAL RECONSTRUCTIONS

PATHWAYS FROM SOCIAL DISCONNECTION TO SUICIDAL IDEATION IN LATER LIFE - ABSTRACT SUICIDE DEATHS AND SOCIAL DISCONNECTION AMONG OLDER ADULTS ARE INCREASINGLY SERIOUS PUBLIC HEALTH CONCERNS. A 'WISH TO DIE' (WTD) IS AN INDICATOR OF PASSIVE SUICIDE IDEATION WHICH REFERS TO THOUGHTS OF ONE’S OWN DEATH, THAT ONE WOULD BE BETTER OFF DEAD, OR WISHING FOR ONE’S DEATH. THE ASSOCIATION BETWEEN SOCIAL DISCONNECTION AND SUICIDE IS WIDELY RECOGNISED AND SOCIAL DISCONNECTION HAS BEEN SHOWN TO BE ASSOCIATED WITH AN INCREASED LIKELIHOOD OF WTD. IMPORTANTLY, SOCIAL DISCONNECTION IS A MULTI-FACETED CONSTRUCT AND BOTH THE QUANTITY (SOCIAL ISOLATION) AND QUALITY (LONELINESS) OF PEOPLE’S SOCIAL RELATIONSHIPS ARE STRONGLY RELATED TO BOTH SUICIDE IDEATION AND SUBSEQUENT SUICIDE ATTEMPTS. WHILE THIS ASSOCIATION IS WELL-ESTABLISHED, THE MECHANISTIC PATHWAYS TO EXPLAIN THE ASSOCIATION ARE LESS WELL UNDERSTOOD. THE MAIN PUTATIVE MECHANISMS PROPOSED ARE: BEHAVIORAL (SLEEP, PHYSICAL ACTIVITY, SMOKING, ALCOHOL CONSUMPTION), PSYCHOLOGICAL (DEPRESSION, ANXIETY, AND AGEING PERCEPTIONS), AND PHYSIOLOGICAL (NEUROENDOCRINE, IMMUNE FUNCTION, AND CARDIOMETABOLIC). THIS STUDY LEVERAGES DATA FROM THE IRISH LONGITUDINAL STUDY ON AGEING (TILDA) TO IDENTIFY THE PATHWAYS THAT EXPLAIN THE ASSOCIATION BETWEEN SOCIAL DISCONNECTION AND PASSIVE SUICIDAL IDEATION. TILDA IS A LARGE, NATIONALLY REPRESENTATIVE, PROSPECTIVE COHORT STUDY THAT EXAMINES THE SOCIAL, ECONOMIC AND HEALTH CIRCUMSTANCES OF 8,500+ COMMUNITY-DWELLING ADULTS AGED 50 YEARS AND OLDER IN IRELAND. TILDA DATA HAVE BEEN COLLECTED EVERY TWO YEARS SINCE 2009 AND INCLUDES BOTH SURVEY DATA (CAPI AND SCQ) AND A COMPREHENSIVE CLINIC-BASED HEALTH ASSESSMENT. DETAILED BIOMARKER DATA ARE AVAILABLE FROM THESE HEALTH ASSESSMENTS AND INCLUDE MARKERS FROM THE NEUROENDOCRINE, IMMUNE, CARDIOMETABOLIC, AND PARASYMPATHETIC SYSTEMS. USING THIS LONGITUDINAL DATA, THE STUDY AIMS TO: (1) IDENTIFY WHO IS AT HIGHEST RISK OF SOCIAL DISCONNECTION AND WTD AMONG OLDER ADULTS AS WELL AS WHEN INDIVIDUALS ARE MOST AT RISK; (2) EXAMINE THE NATURE OF THE ASSOCIATIONS BETWEEN SOCIAL DISCONNECTION AND WTD, INCLUDING STRENGTH, TEMPORALITY, AND DIRECTIONALITY, AMONG OLDER ADULTS; (3) IDENTIFY MECHANISTIC PATHWAYS THAT EXPLAIN THE ASSOCIATION BETWEEN SOCIAL DISCONNECTION AND WTD. TO ADDRESS THESE AIMS, FOUR WAVES OF SURVEY AND TWO WAVES OF BIOMARKER DATA WILL BE INVESTIGATED AND ADVANCED LONGITUDINAL STATISTICAL TECHNIQUES (GLMM, LATENT GROWTH CURVE, LATENT CLASS GROWTH ANALYSIS, AND SEM PATH ANALYSIS) WILL BE APPLIED. GIVEN THE COMPLEX NATURE OF THIS STUDY, WE HAVE ASSEMBLED AN OUTSTANDING MULTI-DISCIPLINARY TEAM OF CLINICAL AND ACADEMIC RESEARCHERS WITH EXPERTISE IN EACH OF THE CONSTITUENT PARTS OF THE PROJECT. BY ESTABLISHING THE CAUSAL PATHWAYS BETWEEN SOCIAL DISCONNECTION AND WTD, STUDY RESULTS WILL IDENTIFY IMPORTANT RISK AND PROTECTIVE FACTORS FOR SUICIDAL IDEATION THAT ARE AMENABLE TO INTERVENTION. IN DOING SO, THE STUDY WILL INFORM EFFECTIVE CLINICAL AND COMMUNITY-BASED INTERVENTIONS BY WHICH THE TRAIN OF THOUGHTS LEADING TO ACTIVE SUICIDAL IDEATION CAN BE STOPPED BEFORE INDIVIDUALS PROGRESS TO ACTIVE IDEATION AND SUICIDAL BEHAVIOR.

RUI: TIME-DEPENDENT INHIBITED SPONTANEOUS EMISSION

MRI-R^2: ACQUISITION OF POWDER X-RAY DIFFRACTION INSTRUMENT FOR FACULTY RESEARCH AND UNDERGRADUATE EDUCATION

MRI: ACQUISITION OF A GAS CHROMATOGRAPH-MASS SPECTROMETER (GCMS) FOR CITIZEN- AND STUDENT-DRIVEN INQUIRY IN URBAN DISTRICT OF COLUMBIA

RUI: HARMONIC ANALYSIS ON WEIGHTED LEBESGUE SPACES

CONSISTENT MULTI-SCALE TREATMENTS OF ION TRANSPORT IN BIOLOGICAL ENVIRONMENTS

COLLABORATIVE RESEARCH: COMPUTATIONAL THINKING THROUGH MOBILE COMPUTING

TAS::57 3600::TAS 'INTERNET OF COMPLEXTHINGS'

RUI: COLLABORATIVE RESEARCH: THE BERMUDA SEAWEED PROJECT

SOFTHUM: STUDENT PARTICIPATION IN THE COMMUNITY OF OPEN SOURCE SOFTWARE FOR HUMANITY

TAS::57 3600::TAS 'COMPLEX SYSTEMS SCIENCE AS A GENERAL FRAMEWORK TO MODEL AND ANALYSE FUNCTIONAL ASPECTS OF WIRELESS NETWORKS'

COLLABORATIVE RESEARCH: RUI: LANDSCAPE-LEVEL CONTROLS ON TERRESTRIAL, AQUATIC, AND WETLAND RESPONSES TO CLIMATE CHANGE IN THE SOUTHERN CANADIAN ARCTI

DEFRAY EXPENSES INCURRED BY TCF, INCLUDING LOST REVENUE, REIMBURSEMENT FOR EXPENSES ALREADY INCURRED, TECHNOLOGY COSTS ASSOCIATED WITH A TRANSITION TO DISTANCE EDUCATION, FACULTY/STAFF TRAININGS, P. E

TRAVEL: UNDERGRADUATE TRAVEL AWARDS FOR THE VISION SCIENCES SOCIETY ANNUAL MEETING -THIS AWARD WILL SUPPORT 26 U.S.-BASED STUDENTS' TRAVEL TO THE VISION SCIENCES SOCIETY (VSS) ANNUAL MEETING (10 STUDENTS IN 2025 AND 16 IN 2026), WHICH WILL BE HELD IN ST. PETERSBURG, FLORIDA. THE VSS CONFERENCE IS A PREMIER VENUE FOR SCIENTISTS WHO ARE INTERESTED IN THE FUNCTIONAL ASPECTS OF VISION. THE VSS ANNUAL MEETING BRINGS TOGETHER IN ONE FORUM SCIENTISTS FROM THE BROAD RANGE OF DISCIPLINES THAT CONTRIBUTE TO VISION SCIENCE, INCLUDING VISUAL PSYCHOPHYSICS, NEUROSCIENCE, COMPUTATIONAL VISION AND COGNITIVE PSYCHOLOGY. THE SCIENTIFIC CONTENT OF THE MEETINGS REFLECTS THE BREADTH OF TOPICS IN MODERN VISION SCIENCE, FROM VISUAL CODING TO PERCEPTION, RECOGNITION AND THE VISUAL CONTROL OF ACTION, AS WELL AS THE RECENT DEVELOPMENT OF NEW METHODOLOGIES FROM COGNITIVE PSYCHOLOGY, COMPUTER VISION AND NEUROIMAGING. STUDENT ATTENDEES WILL BE ABLE TO PRESENT THEIR IDEAS AND PROJECTS TO OTHER ATTENDEES, WHICH CAN HELP THEM DEVELOP THEIR COMMUNICATION AND PRESENTATION SKILLS, RECEIVE VALUABLE FEEDBACK ON THEIR RESEARCH FROM EXPERTS IN THE FIELD, AND EXPAND THEIR PROFESSIONAL NETWORKS WITH RESEARCHERS AND INDUSTRY PROFESSIONALS TO GET THEIR INSIGHTS ON THE LATEST THEORIES, TECHNOLOGIES AND CHALLENGES. STUDENT ATTENDANCE ALSO ENRICHES THE CONFERENCE ITSELF, BRINGING NEW IDEAS AND EXPERIENCES INTO THE COMMUNITY. THIS TRAVEL AWARD WILL PROVIDE CAREER DEVELOPMENT AND LEARNING OPPORTUNITIES IN VSS-RELATED FIELDS FOR U.S.-BASED STUDENTS WHO WOULD OTHERWISE BE LESS LIKELY TO BE ABLE TO ATTEND. CRITERIA FOR SELECTION INCLUDE A DEMONSTRATED INTEREST IN THE FIELD, AS SHOWN THROUGH RESEARCH OUTPUT, COURSEWORK, AND/OR PROJECT EXPERIENCE; NEED FOR FINANCIAL SUPPORT; AND DIVERSITY OF PERSPECTIVES AND BACKGROUNDS. THE ORGANIZING TEAM WILL WIDELY ADVERTISE THE AVAILABILITY OF FUNDING TO INCREASE THE CHANCE OF REACHING POTENTIAL ATTENDEES FROM GROUPS HISTORICALLY UNDERREPRESENTED IN THESE SCIENCES, WITH THE TWIN GOALS OF INCREASING THE BREADTH OF THOUGHTS AND PERSPECTIVES AVAILABLE TO CONFERENCE ATTENDEES AND DEVELOPING THE NEXT GENERATION OF RESEARCHERS AND PRACTITIONERS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

CONFERENCE: DYNAMICS DAYS 2020

6TH GLOBAL SYMPOSIUM ON KETOGENIC THERAPIES FOR NEUROLOGICAL DISORDERS

FIFTH GLOBAL SYMPOSIUM ON KETOGENIC THERAPIES

EUSIPSO - THE 29TH EUROPEAN SIGNAL PROCESSING CONFERENCE

CONFERENCE: DYNAMICS DAYS 2020

WATKINSON LIBRARY ALMANAC PRESERVATION

NSL - BACCALAUREATE NURSING - CLOSEOUT DOCUMENT NUMBER

NSL - ASSOCIATE NURSING - CORRECTIONS IN BUDGET PERIOD/PROJECT PERIOD

RUI: STUDYING FUNDAMENTAL LECTRON-PHOTON INTERACTIONS WITH AN ULTRAFAST ELECTRON MICROSCOPE