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SBIR PHASE II: HIGH THROUGHPUT AND ANTIGEN SPECIFIC T-CELL RECEPTOR DISCOVERY FOR SOLID TUMOR TREATMENTS -THE BROADER IMPACT OF THIS SMALL BUSINESS INNOVATION (SBIR) PHASE II PROJECT IS TO ENABLE DISCOVERY OF NEEDED T-CELL RECEPTOR (TCR) BASED THERAPEUTICS FOR LATE-STAGE CANCER PATIENTS WHO HAVE LIMITED TREATMENT OPTIONS. THESE IMMUNOTHERAPIES WORK BY LEVERAGING T-CELLS ENGINEERED WITH TCRS THAT WILL IDENTIFY AND DESTROY CANCER CELLS THAT NATURALLY PRESENT A TARGET (ANTIGEN) SPECIFIC TO THE CANCER ON THEIR SURFACE (E.G., CANCER MUTATIONS). THIS PROJECT WILL APPLY A NOVEL HIGH-THROUGHPUT PLATFORM DEVELOPED IN PHASE I TO SCREEN MILLIONS OF TCRS AGAINST A LARGE SET OF CANCER-RELATED ANTIGENS TO IDENTIFY CLINICALLY RELEVANT TCRS AND VALIDATE THE MOST PROMISING TCRS FOR CANCER-SPECIFIC IN-VITRO AND IN-VIVO KILLING. THIS PROJECT COULD IMPACT SOCIETY?S HEALTH BY DISCOVERING TCRS THAT WILL SERVE AS THE BASIS FOR TREATMENTS AGAINST CURRENTLY INCURABLE CANCERS (E.G. BREAST CANCER). THE COMMERCIAL IMPACTS ARE POTENTIALLY LARGE. THE TOTAL MARKET SIZE OF T-CELL THERAPEUTICS WAS $2.4 BILLION IN 2018 AND IS ESTIMATED TO REACH $8.5 BILLION BY 2027. THE PLATFORM DESCRIBED BY THIS PROPOSAL HAS THE POTENTIAL TO DISCOVER MANY TCR BASED THERAPEUTICS, CREATING VALUE FOR PATIENTS AND SOCIETY AT LARGE. THE PROPOSED PROJECT IS TO IDENTIFY CLINICALLY VALUABLE TCRS BY APPLYING A HIGH-THROUGHPUT TCR SCREENING PLATFORM DEVELOPED IN PHASE I. DATA GENERATED BY THIS PROJECT COULD BE CRITICAL FOR DEVELOPING NEW IMMUNOTHERAPIES AGAINST SOLID TUMORS AND FOR UNDERSTANDING THE BIOLOGY THAT UNDERLIES TCR-ANTIGEN INTERACTION. SCREENING MILLIONS OF TCRS FOR FUNCTIONAL ACTIVATION AGAINST A LARGE SET OF CLINICALLY RELEVANT CANCER ANTIGENS IS CHALLENGING, AS CONVENTIONAL SCREENING TECHNOLOGIES ARE LARGELY LIMITED TO SCREENING ONE ANTIGEN AT A TIME. IN CONTRAST, THE HIGH-THROUGHPUT SCREENING ASSAY DEVELOPED IN PHASE I IS CAPABLE OF TRACKING INTERACTIONS BETWEEN HUNDREDS OF THOUSANDS OF UNIQUE CELLS, WHERE EVIDENCE LINKING TCR INTERACTION WITH SPECIFIC ANTIGENS THAT IS CAPTURED AND READ OUT VIA SINGLE-CELL SEQUENCING. THIS PROJECT WILL GENERATE DATA DIRECTLY LINKING TCRS WITH 62 CLINICALLY IMPORTANT ANTIGEN TARGETS. THE MOST PROMISING TCRS DISCOVERED WILL THEN BE VALIDATED FOR SPECIFIC AND POTENT INTERACTION AGAINST A TARGET WITH IN-VIVO AND IN-VITRO EXPERIMENTS. THE OBJECTIVE OF THIS PROJECT IS TO DISCOVER AND VALIDATE A NUMBER OF ANTI-CANCER TCRS AND GENERATE PRE-CLINICAL DATA PACKAGES THAT ILLUSTRATE THEIR VALUE AS POTENTIAL THERAPEUTIC DRUGS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

MOBILITYCOACH: A COMPREHENSIVE TELE-REHABILITATION SYSTEM THAT IMPROVES RURAL SENIORS' RETURN TO MOBILITY AND FUNCTION AFTER ORTHOPEDIC SURGERY

FIDDLE - FIT (FOR) INTELLECTUAL DEVELOPMENTAL DETERMINATIONS (FOR) LONG-TERM EMPLOYMENT - THE US IS EXPERIENCING WORKFORCE SHORTAGES IN SECTORS SUCH AS MANUFACTURING, HOSPITALITY, FOOD SERVICE AND HEALTH CARE. THESE ARE AREAS THAT COULD BE FILLED BY UNDER EMPLOYED JOB SEEKERS WITH INTELLECTUAL DEVELOPMENTAL DISABILITY (ID), SUCH AS THOSE WITH AUTISM SPECTRUM DISORDER, DOWN SYNDROME, AND THOSE WITH AN ACQUIRED BRAIN INJURY. NEW EVIDENCE SUPPORTS THE CONCEPT OF NEW TOOLS CAN HELP THE JOB SEEKER WITH AN ID, THEIR EMPLOYMENT-RELATED STAFF, AND POTENTIAL EMPLOYERS OF EMPLOYEES WITH AN ID. THIS STUDY EXPLORES THE BENEFITS OF WEB-BASED TOOLS TO ENHANCE KEY STEPS IN THE PRE-EMPLOYMENT AND EMPLOYMENT PROCESS. WITHOUT FIDDLE, EMPLOYMENT SPECIALISTS MUST RELY ON TRADITIONAL APPROACHES. COMBINED WITH THE CRITICAL SHORTAGE OF EMPLOYMENT SPECIALISTS AND JOB DEVELOPERS, THIS WILL EXACERBATE THE STRAIN ON SCARCE RESOURCES. PHASE I DEMONSTRATED THE TECHNICAL MERIT, FEASIBILITY, AND COST EFFECTIVENESS OF COMBINING AVAILABLE WEB-BASED TOOLS AND AN INNOVATIVE APPROACH TO CREATE THE FIDDLE SYSTEM AND TESTED WITH 10 JOB SEEKERS WITH ID AND THEIR SUPPORT STAFF. PHASE II OBJECTIVES INCLUDE: 1) COMPLETING THE WEBSITE SOFTWARE AND CLOUD-BASED DASHBOARD, 2) INTEGRATING NEW SERVICES INCLUDING AI, AND 3) ADMINISTERING AN EXTENDED FIELD EVALUATION OF FIDDLE WITH JOB SEEKERS, JOB DEVELOPERS, AND EMPLOYERS (N=40) COMPARED WITH A CONTROL GROUP (N=40).

MY SKILLS COACH BUILDING COMPETENCY PAK. A SELF-REGULATING TOOL FOR INDIVIDUALS WITH AN INTELLECTUAL DISABILITY WITH CO-OCCURRING BEHAVIORAL HEALTH ISSUES - APPROXIMATELY 50% OF THE ADULTS WITH AN INTELLECTUAL DISABILITY (ID) EXPERIENCE CO-OCCURRING BEHAVIORAL HEALTH (BH) ISSUES AND DEMONSTRATE CHALLENGING BEHAVIORS. THE EVIDENCE SUGGESTS THAT THE COMMON SOLUTIONS TO HELP CONSUMERS WITH ID/BH, INTENSIFY BEHAVIORAL DYSCONTROL, RATHER THAN REDUCE IT. ENVIRONMENTAL FACTORS, LIKE CONFLICT BETWEEN CONSUMERS AND THEIR DIRECT SUPPORT PROFESSIONALS (DSP), ARE KNOWN TO CONTRIBUTE TO CHALLENGING BEHAVIORS. INTERVENTIONS THAT HELP INDIVIDUALS WITH ID/BH IMPROVE THEIR SELF-REGULATION CAPACITIES, DECREASE ENVIRONMENTAL STRESSES BETWEEN CONSUMERS AND STAFF, AND DO NOT INCREASE THE NEED FOR ADDITIONAL STAFFING, ARE NECESSARY. TO HELP BREAK THE COSTLY VISCOUS CYCLES OF CHALLENGING BEHAVIORS, THESE INTERVENTIONS ARE NEEDED TO HELP CONSUMERS WITH ID/BH BUILD THE CORE SELF-REGULATION CAPACITIES THAT ALLOW THEM TO MAKE CHANGES IN THEIR LIVES AND REACH PERSONAL GOALS. THE MY SKILLS COACH BUILDING COMPETENCY PAK IS A MULTI-MODAL TECHNOLOGY-BASED SELF-REGULATION PROGRAM THAT OFFERS EMOTION REGULATION SKILLS INSTRUCTION AND SKILLS COACHING WITHIN SUPPORT ENVIRONMENTS THAT PROMOTE ADAPTIVE SKILLS ACQUISITION AND GENERALIZATION. PHASE I MY SKILLS COACH DEMONSTRATED THE TECHNICAL MERIT, FEASIBILITY, AND COST EFFECTIVENESS OF COMBINING COMMERCIALLY AVAILABLE TABLETS AND PROGRAMMABLE AVATARS WITH AN INNOVATIVE APPROACH FOR CONSUMERS WITH ID/BH. THE PHASE II MY SKILLS COACH BUILDING COMPETENCY PAK GIVES CONSUMERS AND STAFF ACCESS TO AN ONLINE EMOTION REGULATION SKILL LEARNING PROGRAM, AS WELL AS PROVIDES CONSUMERS WITH THE MY SKILLS COACH (MSC) APP ON A TABLET FOR THEM TO USE IN THEIR ENVIRONMENTS. THE MSC APP PORTION OF THE BUILDING COMPETENCY PAK WILL HELP CONSUMERS BUILD THEIR PERSONAL SELF-REGULATION SKILLS TOOLBOX AND OFFER IN-VIVO SKILLS COACHING SUPPORT VIA THEIR OWN AVATAR. MY SKILLS COACH WILL BE USED IN DAY PROGRAMS IN PHASE II. SPECIFIC PHASE II OBJECTIVES INCLUDE: (1) USE DATA FROM PHASE I TO DESIGN THE PHASE II PROT OTYPE; (2) ENHANCE AND EXPAND THE FEATURES AND FUNCTIONS OF THE PROTOTYPE IN PREPARATION FOR AN EXPANDED FIELD STUDY; (3) PERFORM AN EXTENDED USABILITY EVALUATION OF THE MSC IN DAY PROGRAM SETTINGS; AND (4) PREPARE FOR A SMOOTH TRANSITION TO COMMERCIALIZATION.ANTICIPATED RESULTS AND IMPLICATIONS OF THE APPROACH: MY SKILLS COACH BUILDING COMPETENCY PAK WILL HELP INDIVIDUALS WITH ID/BH INCREASE SELF-REGULATION BEHAVIORS. EVIDENCE SUPPORTS THAT THESE INDIVIDUALS ARE UNDERSERVED BY EXISTING TECHNOLOGY. THE BUILDING COMPETENCY PAK PROVIDES RESOURCES THAT PROMOTE INDEPENDENCE, ENHANCE SELF-ESTEEM, AND CREATE OPPORTUNITIES FOR SELF-REGULATION SKILL DEVELOPMENT USING RESPECTFUL, NON-INVASIVE APPROACHES. POTENTIAL COMMERCIAL APPLICATIONS: THE PRIMARY POTENTIAL COMMERCIAL MARKETS FOR MY SKILLS COACH BUILDING COMPETENCY PAK ARE 1) STATES? DEPARTMENTS OF DISABILITIES AND MANAGED CARE COMPANIES THAT FUND SERVICES FOR CONSUMERS WITH ID/BH AND CHALLENGING BEHAVIORS, 2) PUBLIC AND PRIVATE AGENCIES THAT SUPPORT CONSUMERS WITH ID/BH IN COMMUNITY-BASED SETTINGS OR MULTI-PERSON LIVING SETTINGS WHO LACK SELF-REGULATION CAPACITIES, AND 3) DAY AND VOCATIONAL PROGRAMS. A SECONDARY MARKET INCLUDES THE PRIVATE MARKET FOR INDIVIDUALS CARING FOR A LOVED ONE WITH ID/BH.

NGAGE: A NEUROLOGICAL GUIDANCE, ASSESSMENT, GOALS AND ENGAGEMENT SYSTEM FOR PEOPLE WITH PARKINSON?S AND OTHER DEGENERATIVE NEUROLOGICAL DISEASES

WHENWEAR ADVISOR - A CLOUD-BASED TOOL TO HELP SUPERVISORS INCREASE EMPLOYMENT OPTIONS FOR WORKERS WITH INTELLECTUAL DISABILITIES.

A UNIVERSAL HOME ENVIRONMENT FOR INDIVIDUALS WHO ARE BLIND OR HAVE VISUAL IMPAIRMENTS

SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM

SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM

RURAL-HEALTH-MATE: A TELE-MONITORING SYSTEM THAT IMPROVES RURAL SENIOR'S HEALTHCARE VIA MONITORING, COMMUNICATION & STAKEHOLDER INTERACTION

THE STRENGTHENING HEALTH AND PHYSICAL EDUCATION (SHAPE) PROJECT

NEXT GENERATION REGENERATIVE THERAPY WITH PIM-1 ENHANCED CARDIAC PROGENITOR CELLS

COMPUTATIONAL ALGORITHM TO PREDICT INTERACTING MHC ALLELES FROM TCR SEQUENCES - ABSTRACT MAJOR HISTOCOMPATIBILITY COMPLEXES (MHC) GUIDE IMMUNE RESPONSE BY PRESENTING ANTIGEN FRAGMENTS ON A CELL’S SURFACE AND INTERACTING WITH T-CELL RECEPTORS (TCRS). IN RECENT YEARS, MANY T-CELL THERAPIES HAVE SUCCESSFULLY ENGINEERED T-CELLS TO TARGET MHC-ANTIGEN COMPLEXES ASSOCIATED WITH CANCERS AND OTHER DISEASES. HOWEVER, MOST T-CELL THERAPIES REQUIRE IDENTIFYING A TCR THAT INTERACTS WITH AN MHC-ANTIGEN COMPLEX OF INTEREST, A SLOW AND EXPENSIVE SEARCH PROCESS. OUR PROPOSAL AIMS TO SPEED UP THIS SEARCH PROCESS THROUGH A COMPUTATIONAL ALGORITHM THAT WILL PREDICT WHETHER A TCR WILL INTERACT WITH AN MHC ALLELE OF INTEREST. CURRENT SCREENING ASSAYS FOR LOW FREQUENCY TCRS HAVE HIGH FALSE POSITIVE RATES. RESEARCHERS CAN USE OUR TOOL TO COMPUTATIONALLY FILTER TCR CANDIDATES FOR INTERACTION WITH A SPECIFIC MHC ALLELE BEFORE RUNNING EXPENSIVE VALIDATION EXPERIMENTS. IN THIS PROPOSAL, WE WILL FIRST VALIDATE OUR APPROACH THROUGH A PROTOTYPE ALGORITHM THAT WE WILL TRAIN ON PUBLIC TCR-MHC INTERACTION DATA. WE WILL THEN CONDUCT NEW TETRAMER STAINING EXPERIMENTS THAT ADDRESS TWO MAJOR CHALLENGES FOR DEVELOPING AN ALGORITHM ACROSS MULTIPLE MHC ALLELES: THE LACK OF INTERACTION DATA FOR ALLELES OTHER THAN A*02, AND THE LIMITED ANTIGEN DIVERSITY IN EXISTING PUBLIC DATA. THESE EXPERIMENTS WILL PROVIDE TCR-MHC DATA ACROSS 800 ANTIGENS FOR FOUR COMMON MHC ALLELES: A*01:01, A*02:01, A*11:01, AND B*07:02. FINALLY, WE WILL CONSTRUCT AND VALIDATE COMPUTATIONAL ALGORITHMS FOR EACH MHC ALLELE AND EVALUATE THE IMPORTANCE OF VARIOUS TCR COMPONENTS (E.G., ALPHA OR BETA CHAN, CDR3) IN PREDICTING TCR-MHC INTERACTION. OUR WORK WILL RESULT IN THE FIRST COMPUTATIONAL TOOL TO HELP T-CELL THERAPY DEVELOPERS FILTER TCR CANDIDATES BASED ON MHC SPECIFICITY. BEYOND CELL THERAPIES, THIS TOOL WILL ALSO HELP RESEARCHERS TRACK T-CELLS IN DISEASES WHERE MHC ALLELES PLAY A MAJOR ROLE.

SBIR PHASE I: HIGH THROUGHPUT AND ANTIGEN SPECIFIC T-CELL RECEPTOR DISCOVERY THROUGH ENGINEERED MACROPHAGES -THE BROADER IMPACT OF THIS SMALL BUSINESS INNOVATION (SBIR) PHASE I PROJECT IS TO ENABLE DISCOVERY OF NEEDED T-CELL RECEPTOR (TCR) BASED THERAPEUTICS FOR LATE-STAGE CANCER PATIENTS WHO HAVE LIMITED TREATMENT OPTIONS. THESE IMMUNOTHERAPIES WORK BY LEVERAGING T-CELLS ENGINEERED WITH TCRS THAT WILL IDENTIFY AND DESTROY CANCER CELLS THAT NATURALLY PRESENT A MARKER (ANTIGEN) SPECIFIC TO THE CANCER ON THEIR SURFACE (E.G., CANCER MUTATIONS). THIS PROJECT WILL DEVELOP A HIGH-THROUGHPUT PLATFORM CAPABLE OF SCREENING MANY THOUSANDS OF TCRS AGAINST MANY THOUSANDS OF ANTIGENS TO IDENTIFY CLINICALLY RELEVANT TCRS. THIS PROJECT COULD IMPACT SOCIETY?S HEALTH BY DISCOVERING TCRS THAT WILL SERVE AS THE BASIS FOR TREATMENTS AGAINST CURRENTLY INCURABLE CANCERS. THE COMMERCIAL IMPACTS ARE POTENTIALLY LARGE. THE TOTAL MARKET SIZE OF T-CELL THERAPEUTICS WAS $2.4 BILLION IN 2018 AND IS ESTIMATED TO REACH $8.5 BILLION BY 2027. THE PLATFORM DESCRIBED BY THIS PROPOSAL HAS THE POTENTIAL TO DISCOVER MANY TCR BASED THERAPEUTICS, CREATING VALUE FOR PATIENT AND SOCIETY AT LARGE. THE PROPOSED PROJECT IS TO DEVELOP A PLATFORM FOR IDENTIFYING CLINICALLY VALUABLE TCRS. THIS PLATFORM COULD BE CRITICAL FOR DEVELOPING NEW IMMUNOTHERAPIES AGAINST SOLID TUMORS AND FOR UNDERSTANDING THE BIOLOGY THAT UNDERLIES TCR-ANTIGEN INTERACTION. SCREENING THOUSANDS OF TCRS FOR FUNCTIONAL ACTIVATION AGAINST THOUSANDS OF ANTIGENS IS CHALLENGING DUE TO THE DIFFICULTY OF TRACKING INTERACTIONS BETWEEN HUNDREDS OF THOUSANDS OF UNIQUE CELLS. THE PROPOSED PLATFORM AND METHOD LINKS T-CELL ACTIVATION WITH PHAGOCYTOSIS USING ENGINEERED T-MACROPHAGE AND ANTIGEN PRESENTING CELL (APC) LINES. T-MACROPHAGES ENGULF APCS AS DIRECTED BY TCR ACTIVATION, CAPTURING EVIDENCE OF AN INTERACTION WITHIN THE T-MACROPHAGE. THE RESULTING INTERACTIONS CAN BE READ FROM THE T-MACROPHAGES VIA SINGLE-CELL SEQUENCING. THE OBJECTIVE OF THIS PROJECT IS TO PRODUCE LARGE CELL-BASED LIBRARIES FOR TCR AND ANTIGENS AND TO IDENTIFY INTERACTING TCR-ANTIGEN PAIRS. THE ANTIGEN LIBRARY WILL INCLUDE HUNDREDS OF CLINICALLY RELEVANT CANCER TARGETS, SUCH AS KRAS AND TP53. THESE RESULTS WILL DEMONSTRATE THE FEASIBILITY OF OUR PLATFORM. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

PURPOSE: TO SUPPORT SUBGRANTING TO THE NONPROFIT ARTS SECTOR IN RESPONSE TO AND RECOVERY FROM THE COVID-19 PANDEMIC.

BACTERIALLY-SECRETED GLP-1 INDUCED REPROGRAMMING OF INTESTINAL CELLS AS A TREATME

FUNDA VIDA WILL PROVIDE SUPPORT IN PARTNERSHIP WTIH CARSI EFFORTS TO COMBAT THE DRUG TRADE THROUGH COMMUNITY AND ECONOMY DEVELOPMENT.

VARIABLE PROMPTING TECHNOLOGY FOR IMPROVING THE ADL TASK PERFORMANCE OF OLDER ADU

GOALS - GOAL ORIENTED AUTOMATED LEARNING SYSTEM TO ENHANCE THE COMMUNICATION OF TASK ASSIGNMENTS FROM SUPERVISORS TO EMPLOYEES WITH AN INTELLECTUAL DISABILITY. - CREATEABILITY CONCEPTS, INC. 5058 EVANSTON AVENUE, INDIANAPOLIS, INDIANA 46205 PRINCIPAL INVESTIGATOR: STEPHEN M. SUTTER, PRESIDENT TECHNICAL ABSTRACT THE US IS EXPERIENCING WORKFORCE SHORTAGES IN SECTORS SUCH AS MANUFACTURING, HOSPITALITY, FOOD SERVICE AND LOGISTICS. IRONICALLY, THESE COULD BE FILLED BY EMPLOYEES WITH AN INTELLECTUAL DISABILITY (ID), SUCH AS THOSE WITH AUTISM, DOWN SYNDROME, AND THOSE WHO HAVE HAD A BRAIN INJURY. YET PEOPLE WITH ID ARE UNDER EMPLOYED. TO HELP FILL THE GAP LEFT BY THE SHORTAGE OF JOB COACHES, NEW EVIDENCE SUPPORTS THE CONCEPT THAT AI-ASSISTED TASK ANALYSIS TOOLS CAN HELP EMPLOYEES WITH ID BETTER UNDERSTAND THE JOB TASK TO BE PERFORMED AT THE APPROPRIATE DETAIL. WITHOUT GOALS, SUPERVISORS MUST RELY ON TRADITIONAL APPROACHES. COMBINED WITH THE CRITICAL SHORTAGE OF JOB COACHES, AND JOB TRENDS (INCREASED MOBILITY, INCREASED FLEXIBILITY AND CHANGING WORK ASSIGNMENTS) THIS WILL EXACERBATE THE STRAIN ON SCARCE RESOURCES AND THREATEN EMPLOYMENT SUSTAINABILITY OF MANY EMPLOYEES WITH AN ID. THIS PROJECT WILL DEMONSTRATE THE TECHNICAL MERIT, FEASIBILITY, AND COST EFFECTIVENESS OF COMBINING AVAILABLE WEB-BASED TOOLS, AI, AND AN INNOVATIVE APPROACH TO CREATE THE GOALS SYSTEM. SPECIFIC PHASE I OBJECTIVES INCLUDE: 1) DETERMINE END USER REQUIREMENTS, 2) DEVELOP A PROOF-OF-CONCEPT PROTOTYPE OF THE SYSTEM, AND 3) EVALUATE OF THE UTILITY OF THE PROTOTYPE WITH EMPLOYEES WITH AN ID, THEIR JOB COACHES, AND SUPERVISOR AT THEIR EMPLOYER. ANTICIPATED RESULTS AND IMPLICATIONS OF THE APPROACH EVIDENCE SUPPORTS THAT EMPLOYEES WITH AN ID ARE UNDER SERVED BY EXISTING TECHNOLOGY. GOALS WILL HELP ADULT AGED EMPLOYEES WITH AN ID TO HAVE INCREASED INFORMED CHOICE REGARDING HOW TASK ASSIGNMENTS ARE PRESENTED TO THEM. GOALS WILL RESULT IN A STANDARDIZED, COST-EFFECTIVE OPTION TO GUIDE THE EMPLOYEE THROUGH THE STEPS IN THE ACCOMPLISHMENT OF JOB GOALS, RESULTING IN BETTER UNDERSTANDING OF WHAT IS EXPECTED OF THEM, AND MORE SUSTAINABLE EMPLOYMENT. THE BUILT-IN NATURAL SUPPORT MECHANISMS WILL ENHANCE SELF-ESTEEM, REDUCE ANXIETY, INCREASE EFFICIENCIES, AND CREATE OPPORTUNITIES FOR SELF-DIRECTION USING A RESPECTFUL, AND FUN APPROACH. POTENTIAL COMMERCIAL APPLICATIONS THE PRIMARY POTENTIAL COMMERCIAL MARKETS FOR GOALS ARE 1) EMPLOYERS OF PEOPLE WITH ID, 2) EMPLOYMENT SUPPORT PROVIDERS, AND 3) STATE AGENCIES WHO WISH TO STANDARDIZE THE EMPLOYMENT SUPPORT PROCESSES AND IMPROVE EFFICIENCIES FOR INDIVIDUALS ON A MEDICAID WAIVER, OR FOR JOB SEEKERS WHO ARE APPROVED TO RECEIVE SERVICES FROM VOCATIONAL REHABILITATION.

THE CLIENT OPTIMIZED VIRTUAL EQUINE THERAPY SYSTEM TO HELP CHILDREN WITH AUTISM

FIDDLE - FIT (FOR) INTELLECTUAL DEVELOPMENTAL DETERMINATIONS (FOR) LONG-TERM EMPLOYMENT

STEADYGAIT: A WEARABLE FEEDBACK DEVICE TO HELP PEOPLE WITH PARKINSON?S DISEASE REDUCE FALLS

MY SKILLS COACH, A MOBILE AND CLOUD-BASED TOOL TO HELP INDIVIDUALS WITH AN INTELLECTUAL DISABILITY WITH CO-OCCURRING BEHAVIORAL HEALTH ISSUES

NGAGE, A NEUROLOGICAL GUIDANCE, ASSESSMENT, GOALS AND ENGAGEMENT SYSTEM FOR PEOPLE WITH PARKINSONS AND OTHER DEGENERATIVE NEUROLOGICAL DISEASES

PURPOSE: TO SUPPORT CREATE CA AN ONGOING STATEWIDE COLLECTIVE IMPACT COALITION FOR ARTS EDUCATION IN CALIFORNIA SCHOOLS.

PURPOSE: TO SUPPORT CREATE CA AN ONGOING STATEWIDE COLLECTIVE IMPACT COALITION FOR ARTS EDUCATION IN CALIFORNIA SCHOOLS.

TO SUPPORT CREATE CA AN ONGOING STATEWIDE COALITION FOR COLLECTIVE IMPACT IN ARTS EDUCATION IN CALIFORNIA SCHOOLS.

TO SUPPORT CREATE CA AN ONGOING STATEWIDE COALITION FOR COLLECTIVE IMPACT IN ARTS EDUCATION IN CALIFORNIA SCHOOLS.

TO SUPPORT CREATE CA A STATEWIDE COALITION FOR COLLECTIVE IMPACT IN ARTS EDUCATION IN CALIFORNIA SCHOOLS.

TO SUPPORT CREATE CA, A COALITION FOR COLLECTIVE IMPACT IN ARTS EDUCATION.

TO SUPPORT CREATE CA, A COALITION FOR COLLECTIVE IMPACT IN ARTS EDUCATION IN CALIFORNIA SCHOOLS.

AS WE RAISE FOOD IN THE US, COMPETENT LABOR PREPARED TO MANAGE DAILY LIVESTOCK MORTALITIES AND POTENTIAL DEPOPULATION CATASTROPHES, AS AGRICULTURE FACES NOW DURING COVID-19, MAXIMIZES THE ABILITY FOR AMERICAN PRODUCERS TO PROSPER. KNOWING DEPOPULATION COULD HAPPEN AGAIN WITH FOREIGN ANIMAL DISEASE (FAD), OUR COVID-19 EXPERIENCES UNDERLINE THE IMPORTANCE OF INNOVATIVE, COMPETENCY-BASED EDUCATIONAL TECHNOLOGIES TO BEST PREPARE FARM LABOR TO CARE FOR DAILY LIVESTOCK MORTALITIES AND ALSO BE READY TO MANAGE CARCASSES DURING CATASTROPHES. EXPANDING MORTALITY MANAGEMENT TRAINING VIA TECHNOLOGIES LIKE THIS GOES BEYOND THE FARM AND CONTRIBUTES TO ENVIRONMENTAL STEWARDSHIP THUS ADDING TO SOCIETAL VALUE.PHASE I WILL PROVE TECHNOLOGY EFFICACY VIA RESEARCH AND DEVELOPMENT OF AN INNOVATIVE AND ENGAGING COMPETENCY-BASED EDUCATIONAL LAB PROTOTYPE, ALONGSIDE PRE- AND POST- TRAINING ASSESSMENT. RESULTS WILL DRIVE POTENTIAL PHASE II EDUCATIONAL RESEARCH, DEVELOPMENT, AND COMMERCIALIZATION OF COMPETENCY-BASED EDUCATIONAL TECHNOLOGY RELATED TO THE PROTECTION OF AGRICULTURAL ANIMALS IN A WAY THAT ENHANCES THE BIOSECURITY OF OUR HERDS AND FLOCKS. PRELIMINARY RESEARCH SHOWS THAT BASELINE COMPETENCIES RANGE FROM 25-60% WITH TRADITIONAL TRAINING METHODS. WE ANTICIPATE THIS INNOVATION WILL ACHIEVE BETWEEN 85-100% COMPETENCY POST TRAINING.TO COMMERCIALIZE, WE WOULD PLACE ON ONLINE LEARNING MANAGEMENT SOFTWARE AND CHARGE SUBSCRIPTIONS PER EMPLOYEE PER YEAR TO ACCESS THE TECHNOLOGY ALONGSIDE A LIBRARY OF LEARNING EXPERIENCES. AS WE DELIVER AND MARKET THE POSITIVE PROOF OF THIS INNOVATIVE LAB PROTOTYPE POST PHASE I, THIS INCREASES AND MAINTAINS SUBSCRIPTION WHILE AUGMENTING OUR ABILITY TO FURTHER COMMERCIALIZE AND REACH NEW SUBSCRIBERS. IMPROVING AMERICAN LABOR COMPETENCIES ALLOWS AMERICAN PRODUCERS TO REMAIN COMPETITIVE IN THE GLOBAL MARKETPLACE AND CONTRIBUTES TO GLOBAL FOOD SECURITY.

MOBILITYCOACH: A COMPREHENSIVE TELE-REHABILITATION SYSTEM THAT IMPROVES RURAL SENIORS' RETURN TO MOBILITY AND FUNCTION AFTER ORTHOPEDIC SURGERY

RURAL-HEALTH-MATE: A TELE-MONITORING SYSTEM THAT IMPROVES RURAL SENIOR'S HEALTHCARE VIA MONITORING, COMMUNICATION AND STAKEHOLDER INTERACT

PURPOSE: TO SUPPORT A GRANT PROGRAM FOR NONPROFIT ORGANIZATIONS AND INDIVIDUAL ARTISTS IN SANTA CLARA COUNTY CALIFORNIA. 

ALERT: ACTIVITIES OF LIVING, ENGAGEMENT AND REPORTING TECHNOLOGY TO ENHANCE QUALITY OF LIFE FOR RURAL OLDER ADULTS

RBDG RURAL BUSINESS COOP RURAL ENTERPRISE GRANT

TOURISM DEVELOPMENT

SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM

SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM

SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM

SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM

MEMBRAIN: A NON-INVASIVE SAFETY NET THAT SAFEGUARDS YOUNG ADULTS WITH AUTISM TRANSITIONING TO INDEPENDENT LIVING

WHENWEAR ADVISOR: A CLOUD-BASED TOOL TO HELP SUPERVISORS INCREASE EMPLOYMENT OPTIONS FOR WORKERS WITH INTELLECTUAL DISABILITIES.

TO SUPPORT CREATE CA AN ONGOING STATEWIDE COLLECTIVE IMPACT COALITION FOR ARTS EDUCATION IN CALIFORNIA SCHOOLS.

TO SUPPORT A PLACEMAKING WORKSHOP AND A SERIES OF COMMUNITY DESIGN CHARRETTES FOCUSED ON THE RE-DESIGN OF HISTORIC CASTONGUAY SQUARE.

SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM

HEADLAMP - A TABLET AND SMART-GLASSES-BASED HOME ELECTRONIC AIDS FOR DAILY LIVING SYSTEM FOR

PURPOSE: TO SUPPORT A GRANT PROGRAM FOR NONPROFIT ORGANIZATIONS AND INDIVIDUAL ARTISTS IN SANTA CLARA COUNTY CALIFORNIA.

COMMUNITY FACILITY GRANTS

PURPOSE: TO SUPPORT ARTS INSTRUCTION FOR YOUTH AND YOUNG ADULTS IN ST. LOUIS.

PURPOSE: TO SUPPORT AN EXHIBITION OF THE WORK OF BIRMINGHAM SCULPTOR JOE MINTER.

TO SUPPORT THE COMMUNITY ARTS FUND, A SUBGRANTING PROGRAM THAT SUPPORTS ARTISTIC PROGRAMMING PRESENTED BY ARTS ORGANIZATIONS IN SANTA CLARA COUNTY.

TO SUPPORT THE COMMUNITY ARTS FUND (CAF).

RBDG RURAL BUSINESS COOP RURAL ENTERPRISE GRANT

DROPOUT PREVENTION

PURPOSE: TO SUPPORT CITYDANCE SAN JOSE A SERIES OF FREE OUTDOOR ARTS EVENTS.

PURPOSE: TO SUPPORT FREE VISUAL ARTS CLASSES FOR YOUTH.

THE GRANT WILL SUPPORT THE RECIPIENT TO BRING IN AMERICAN SPEAKER STEVE SEIDEL DIRECTOR OF PROJECT ZERO TO SINGAPORE TO CONDUCT A SERIES OF WORKSHO

PURPOSE: TO SUPPORT WORKSHOPS AND A COMMEMORATIVE ART EXHIBITION. 

PURPOSE: TO SUPPORT DIGITAL MEDIA ARTS PROGRAMMING AND TRAINING FOR YOUTH.

PURPOSE: TO SUPPORT AN SVCREATES GRANT PROGRAM IN SANTA CLARA COUNTY CALIFORNIA.

TO SUPPORT THE COMMUNITY ARTS FUND (CAF), A REGRANTING PROGRAM.

TO SUPPORT THE COMMUNITY ARTS FUND (CAF).

ORGANIZATIONAL CAPACITY

PURPOSE: TO SUPPORT DIGITAL MEDIA ARTS PROGRAMMING AND TRAINING FOR YOUTH.

TO SUPPORT PROJECTARTS MENTOR-LED VISUAL ARTS EDUCATION PROGRAM.

PURPOSE: TO SUPPORT PROJECTARTS MENTOR-LED VISUAL ARTS EDUCATION PROGRAM.

PURPOSE: TO SUPPORT PROJECTARTS MENTOR-LED VISUAL ARTS EDUCATION PROGRAM.

PURPOSE: TO SUPPORT PROJECTARTS MENTOR-LED VISUAL ARTS EDUCATION PROGRAM.

TO SUPPORT THE DIGITAL MEDIA PROGRAM. 

TO SUPPORT PROJECTARTS MENTOR-LED VISUAL ARTS EDUCATION PROGRAM.

TO SUPPORT THE DIGITAL CREATION STUDIO.

TO SUPPORT PROJECTARTS MENTOR-LED VISUAL ARTS EDUCATION PROGRAM.

TO SUPPORT TEACHING ARTIST FEES AND STAFF COSTS FOR PROJECTARTS VISUAL ARTS EDUCATION PROGRAM.

TO SUPPORT A PILOT ARTIST RESIDENCY PROGRAM.

COMMUNITY FACILITY GRANTS

THIS GRANT SUPPORTS THE COSTS INCURRED TO IMPLEMENT MEASURES TO RESPOND TO THE NOVEL CORONAVIRUS 2019 (COVID-19), WHICH MAY INCLUDE WORKPLACE SAFETY, MARKET PIVOTS, RETROFITTING FACILITIES, TRANSPORTATION, WORKER HOUSING, AND MEDICAL EXPENSES. IT PROVIDES NEEDED RELIEF TO THE FOOD PROCESSORS, DISTRIBUTORS, FARMERS MARKETS, AND PRODUCERS FOR THEIR COSTS INCURRED BETWEEN JANUARY 27, 2020, THE DATE UPON WHICH THE PUBLIC HEALTH EMERGENCY WAS DECLARED BY THE U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICE (HHS) UNDER SECTION 319 OF THE PUBLIC HEALTH SERVICE ACT, AND DECEMBER 31, 2021. BENEFICIARIES INCLUDE THE EMPLOYEES OF THE FOOD PROCESSORS, DISTRIBUTORS, FARMERS MARKETS, AND PRODUCERS.

PURPOSE: TO SUPPORT MULTIDISCIPLINARY ARTS EDUCATION PROGRAMMING.

PURPOSE: TO SUPPORT DIGITAL MEDIA ARTS PROGRAMMING AND TRAINING.

TO SUPPORT POST-PRODUCTION AND OUTREACH COSTS FOR A DOCUMENTARY BY GEORGE KING ON THE LIFE AND WORK OF ALABAMA ARTIST AND MUSICIAN LONNIE B. HOLLEY.

WORKFORCE TRAINING

PURPOSE: TO SUPPORT A MULTIDISCIPLINARY ARTS FESTIVAL.

WORKFORCE TRAINING

PURPOSE: TO SUPPORT THE CHINATOWN ARTS FESTIVAL.

PURPOSE: TO SUPPORT PROFESSIONAL DEVELOPMENT PROGRAMMING FOR ARTISTS AND ARTS ORGANIZATIONS.

PURPOSE: TO SUPPORT ARTS PROGRAMMING MANAGED BY WATERVILLE CREATES AND PRESENTED AT THE NEW PAUL J. SCHUPF ART CENTER.

TO SUPPORT A PROFESSIONAL DEVELOPMENT PROGRAM FOR ARTISTS AND ARTS ORGANIZATIONS.

TO SUPPORT A STATEWIDE ANALYSIS OF THE ACCESS, EQUITY, QUANTITY, AND DIVERSITY OF ARTS EDUCATION IN CALIFORNIA SCHOOLS.

SEC 9007 REAP-RENEW ENERGY EFFICIENCY IMPROVE GRANTS, $20,000 OR LESS (MAN)

SEC 9007 REAP-RENEW ENERGY SYSTEMS GRANTS, $20,000 OR LESS (MAN)

SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM

SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM

RURAL-HEALTH-MATE: A TELE-MONITORING SYSTEM THAT IMPROVES RURAL SENIOR'S HEALTHCARE VIA MONITORING, COMMUNICATION & STAKEHOLDER INTERACTION