Marist University

MARIST COLLEGE HIGHER EDUCATION EMERGENCY RELIEF FUND - INSTITUTIONAL PORTION

MARIST COLLEGE EMERGENCY FINANCIAL AID GRANTS UNDER CARES ACT

MARIST COLLEGE UPWARD BOUND PROGRAM

UPWARD BOUND

GATEWAY TO SUCCESS: COMBINING FINANCIAL, ACADEMIC AND PSYCHOSOCIAL SUPPORTS TO PROMOTE ACADEMIC SUCCESS OF LOW-INCOME STEM MAJORS

SPECIAL SERVICES / DISABILITY SERVICES

STUDENT SUPPORT SERVICES PROGRAM

HANCOCK TECHNOLOGY CENTER RESEARCH LABORATORY

CC*DNI INTEGRATION (AREA 4): APPLICATION AWARE SOFTWARE-DEFINED NETWORKS FOR SECURE CLOUD SERVICES (SECURECLOUD)

MRI: ACQUISITION OF AN ENTERPRISE LEVEL SYSTEM FOR RESEARCH AND RESEARCH TRAINING

AN APPROACH FOR RECRUITMENT, PERSISTENCE AND RETENTION OF CS/ITS MAJORS

COMPUTER SCIENCE AND INFORMATION TECHNOLOGY SYSTEMS (CS/ITS) COHORT SCHOLARSHIP PROGRAM

HUDSON RIVER VALLEY INSTITUTE AT MARIST COLLEGE

CPATH CB: DEVELOPING A PROFESSIONAL COMMUNITY FOR INTRODUCING THE PRINCIPLES OF ENTERPRISE COMPUTING TECHNOLOGIES INTO THE UNDERGRADUATE CURRICULUM

REU SITE: STATISTICAL MATHEMATICS AND RESEARCH TRAINING (SMART) -THE MARIST UNIVERSITY STATISTICAL MATHEMATICS AND RESEARCH TRAINING (SMART) RESEARCH EXPERIENCES FOR UNDERGRADUATES (REU) PROGRAM WILL OFFER A DISTINCTIVE AND IMMERSIVE RESEARCH OPPORTUNITY FOR NINE UNDERGRADUATE STUDENTS EACH SUMMER FOR THREE YEARS. OVER AN INTENSIVE EIGHT-WEEK PERIOD, PARTICIPANTS WILL ENGAGE IN ORIGINAL RESEARCH PROJECTS IN STATISTICS, DATA SCIENCE, AND MATHEMATICS UNDER THE MENTORSHIP OF DEDICATED FACULTY MEMBERS. WORKING IN SMALL GROUPS, STUDENTS WILL TACKLE COMPLEX AND MEANINGFUL PROBLEMS IN AREAS SUCH AS BAYESIAN STATISTICS, PROBABILITY, MACHINE LEARNING, CONTROL THEORY, MATHEMATICAL MODELING, COMBINATORICS, GRAPH THEORY, AND SIGN LANGUAGE RECOGNITION. THE PROGRAM WILL ALSO FEATURE WEEKLY TALKS BY FACULTY AND STUDENTS, COVERING TOPICS IN MATHEMATICS AND RELATED FIELDS. SMART REU PARTICIPANTS WILL BE PART OF A VIBRANT COMMUNITY OF STUDENTS AND FACULTY CONDUCTING RESEARCH AND OTHER CREATIVE AND INVESTIGATIVE ACTIVITIES OVER THE SUMMER AT MARIST UNIVERSITY. THE SMART REU AIMS TO INTRODUCE UNDERGRADUATES TO THE EXCITEMENT AND CHALLENGES OF CONDUCTING ORIGINAL RESEARCH IN STATISTICS, DATA SCIENCE, AND MATHEMATICS. THROUGHOUT THE PROGRAM, STUDENTS WILL ACQUIRE ESSENTIAL BACKGROUND KNOWLEDGE AND DEVELOP A STRONG FOUNDATION IN RESEARCH ETHICS, INCLUDING PROPER COLLABORATION PRACTICES, CREDIT ATTRIBUTION, AND SOURCE CITATION. AS THE PROGRAM PROGRESSES, PARTICIPANTS WILL PREPARE A FINAL REPORT SUMMARIZING THEIR RESEARCH FINDINGS, WHICH THEY WILL PRESENT AT A LOCAL OR NATIONAL CONFERENCE. WHEN APPROPRIATE, THEIR WORK WILL BE SUBMITTED FOR PUBLICATION IN PEER-REVIEWED JOURNALS. IN ADDITION TO STRENGTHENING THEIR RESEARCH SKILLS AND MATHEMATICAL/STATISTICAL EXPERTISE, STUDENTS WILL REFINE THEIR COMMUNICATION ABILITIES THROUGH REGULAR PRESENTATIONS AND PROJECT UPDATES, RECEIVING CONSTRUCTIVE FEEDBACK FROM FACULTY MENTORS. FOR MORE DETAILS, PLEASE VISIT: WWW.MARIST.EDU/SMART-REU THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

ROLE OF AP-3 IN PROTEIN SORTING AND AUTOPHAGY IN MELANOSOME BIOGENESIS

CHROMATIN-MEDIATED MAINTENANCE OF GENOMIC INTEGRITY IN GERM CELLS - PROJECT SUMMARY ACCUMULATION OF DNA DAMAGE IS A THREAT TO GENOMIC INTEGRITY IN ALL ORGANISMS. DNA DAMAGE CAN RESULT FROM EXTERNAL SOURCES (E.G. RADIATION OR CERTAIN CHEMICALS) AND CAN ALSO OCCUR SPONTANEOUSLY AS A RESULT OF METABOLIC STRESS OR ERRORS IN DNA REPLICATION. THIS AREA OF STUDY IS DIRECTLY RELEVANT TO AGE-RELATED DISEASE AND REPRODUCTIVE FAILURE. TO PREVENT THESE CONDITIONS, IT IS CRUCIAL THAT DNA REPAIR PATHWAYS ARE INTACT. REPAIR OF DNA LESIONS IS CRITICALLY IMPORTANT IN GERM CELLS, THE PRECURSORS OF EGG AND SPERM. IN HUMANS, DEFECTS IN THE RECOGNITION OR RESPONSE TO DNA DAMAGE IN GERM CELLS MANIFEST AS INFERTILITY AND MISCARRIAGE AND ARE ALSO A CAUSE OF DEVELOPMENTAL DISORDERS (E.G. DOWN SYNDROME AND AUTISM SPECTRUM DISORDER). MULTIPLE REPAIR PATHWAYS HAVE BEEN IDENTIFIED THAT RESPOND TO SPECIFIC DNA LESIONS, YET WE LACK A FULL UNDERSTANDING OF THE UNDERLYING MOLECULAR MECHANISMS THAT GUIDE APPROPRIATE REPAIR PATHWAY SELECTION DEPENDING ON CELLULAR CONTEXT. THIS IS HIGHLY SIGNIFICANT, AS REPAIR PATHWAYS DIFFER IN THEIR EFFICACY. DURING SEXUAL REPRODUCTION, FOR EXAMPLE, ONLY ONE TYPE OF REPAIR PATHWAY CAN ACCOMMODATE EXCHANGES IN GENETIC MATERIAL NECESSARY FOR PROPER CHROMOSOME SEGREGATION AND GENETIC DIVERSITY IN OFFSPRING. IN ALL SCENARIOS, EFFICIENT DNA REPAIR REQUIRES A SPECIALIZED CHROMATIN ENVIRONMENT TO ENABLE ACCESS TO LESIONS AND TO RECRUIT APPROPRIATE REPAIR MACHINERY. OUR EXPERIMENTS UTILIZE THE FACILE, GENETIC MODEL CAENORHABDITIS ELEGANS TO DETERMINE THE ROLE OF CHROMATIN REMODELERS IN THE GERM LINE, A PIPELINE OF DIVIDING CELLS THAT GIVE RISE TO EGGS OR SPERM. WE DISCOVERED THAT SUCCESSFUL DNA REPAIR IN GERM CELLS REQUIRES THE NUCLEOSOME REMODELING AND DEACETYLASE (NURD) COMPLEX, ONE OF SEVERAL CONSERVED PROTEIN COMPLEXES IMPORTANT FOR DYNAMIC REGULATION OF EUKARYOTIC CHROMOSOMES. OUR LONG-TERM GOAL IS TO LEARN HOW NURD SENSES AND RESPONDS TO DNA DAMAGE AND PREVENTS THE ACCUMULATION OF HARMFUL MUTATIONS. C. ELEGANS IS IDEAL FOR THESE STUDIES DUE TO ITS SHORT (3-4 DAY) LIFE-CYCLE, PROLIFIC REPRODUCTION, AND A GERM LINE CONDUCIVE TO GENETICALLY- AND CYTOLOGICALLY-TRACTABLE STUDY OF LARGE NUMBERS OF EGG OR SPERM. THE OBJECTIVE OF THIS APPLICATION IS TO ESTABLISH HOW THE CATALYTIC SUBUNIT OF NURD, LET-418 (CHD4 IN HUMANS), ENSURES THE FIDELITY OF DNA REPAIR AND LIMITS ERRORS FROM BEING TRANSMITTED TO OFFSPRING. IN AIM 1, WE WILL USE GENETICALLY-ENGINEERED STRAINS TO PINPOINT HOW LET-418 REPAIRS DNA LESIONS IN GERM CELLS, AND WE WILL USE HIGH THROUGHPUT SEQUENCE ANALYSIS TO QUANTIFY GENOME-WIDE MUTATION RATES IN RESPONSE TO DAMAGE. IN AIM 2, WE WILL DEFINE THE ROLE OF LET-418 IN PROMOTING DNA REPAIR IN RESPONSE TO SPONTANEOUS FORMS OF DNA DAMAGE, AND WE WILL QUANTIFY DNA LESIONS FORMED BY ENDOGENOUS (INTERNAL) CELLULAR STRESS. USING REPORTER STRAINS AND HIGH-RESOLUTION MICROSCOPY, WE WILL DETERMINE THE CONSEQUENCES OF ELEVATED ENDOGENOUS STRESS IN LET-418 MUTANT GERM LINES. IT IS EXPECTED THAT OUR RESULTS WILL ALSO INFORM HOW LIMITING STRESS-INDUCED DNA DAMAGE PREVENTS MISSEGREGATION OF CHROMOSOMES IN FEMALES OF ADVANCED REPRODUCTIVE AGE. ONCE COMPLETED, OUR WORK WILL PROVIDE CRITICAL INSIGHT INTO THE MECHANISTIC CAUSES OF HUMAN REPRODUCTIVE DISORDERS AND WILL GENERATE FINDINGS THAT INFORM THERAPEUTIC STRATEGIES FOR INFERTILITY.

ROLE OF HIGHER ORDER CHROMATIN STRUCTURE IN GAMETE FORMATION

THE MEANINGS OF PROPERTY

THE DIGITAL HUMANITIES CLASS DEVELOPMENT PROJECT

LOWELL THOMAS PAPERS DIGITIZATION PROJECT

ELASTIC WAVE PROPAGATION MECHANISMS IN UNDERWATER ACOUSTIC ENVIRONMENTS

TO SUPPORT THE DIGITIZATION OF HALF A MILLION PAGES OF RADIO NEWS SHOW SCRIPTS FROM THE LOWELL THOMAS PAPERS AND MAKE THE DIGITAL IMAGES AND ASSOCIATED METADATA AVAILABLE ONLINE VIA THE COLLECTION?S FINDING AID. THOMAS (1892-1981) WAS A PIONEERING JOURNALIST WHO BECAME ONE OF THE FOREMOST RADIO BROADCASTERS DURING THE GOLDEN AGE OF RADIO. IN 1976 THOMAS RETIRED FROM HIS RADIO NEWS PROGRAM, WHICH HAD BEEN ON THE AIR FOR 46 CONTINUOUS YEARS.

ELASTIC BOTTOM PROPAGATION MECHANISMS INVESTIGATED BY PARABOLIC EQUATION METHODS

A DIGITAL PATHFINDER FOR HISTORIC SITES