Syracuse University

HIGHER EDUCATION EMERGENCY RELIEF FUND - INSTITUTIONAL AID

HIGHER EDUCATION EMERGENCY RELIEF FUND: STUDENT SUPPORT_CARES ACT

PURPOSE: CREATE AN INNOVATION ASSET AND INNOVATION EXPERTISE ENGAGEMENT NETWORK WITH SEMICONDUCTOR-RELEVANT FACILITIES AND EXPERTISE TO ENABLE SMALL AND MEDIUM SIZED FIRMS TO COLLABORATE WITH COLLEGES, UNIVERSITIES, AND OTHER RESEARCH AND DEVELOPMENT ASSETS. LAUNCH AN INNOVATION VOUCHER PROGRAM TO OFFSET THE COSTS OF USING PHYSICAL AND INTELLECTUAL ASSETS. ESTABLISH ARCHITECTURE TO ALLOW COLLABORATION BETWEEN THE PRIVATE SECTOR AND ACADEMIC RESEARCHERS ON TECHNOLOGY COMMERCIALIZATION. STANDARDIZE IP PROTECTION FOR THE ACADEMIC AND PRIVATE SECTORS, AND PROVIDE GREATER TRANSPARENCY ON LICENSING AGREEMENTS TO PRIVATE SECTOR. DEVELOP A COMMON INNOVATION AGENDA, SHARE KNOWLEDGE, FACILITATE COLLABORATION, AND ESTABLISH AN INTERNSHIP/CO-OP PROGRAM TO INCREASE THE COLLECTIVE CAPACITY OF NY SMART I-CORRIDOR TECH HUB. EXPECTED OUTCOMES: INNOVATION ASSET/EXPERTISE INVENTORY COMPLETED AND FULLY-STAFFED INNOVATION ENGAGEMENT NETWORK BUILT OUT. INNOVATION VOUCHERS USED BY SMALL AND MEDIUM SIZED FIRMS. ACADEMIC AND PRIVATE SECTOR ENTITIES PARTICIPATE IN IP FRAMEWORK, WITH REGULAR IP WORKSHOPS AND MEMORANDA OF UNDERSTANDING ACROSS RESEARCH INSTITUTIONS. COMMUNITY OF PRACTICE FACILITATES KNOWLEDGE SHARING AND COLLABORATION THROUGH MEETINGS AND CONFERENCES, AND UNIVERSITIES ALIGN ON INTERNSHIP PROGRAMS. INTENDED BENEFICIARIES: INNOVATION ASSET MAPPING AND INNOVATION VOUCHERS SUPPORT SMALL AND MEDIUM SIZED BUSINESSES COMMERCIALIZING TECHNOLOGIES. ACADEMIC AND PRIVATE SECTOR PARTICIPANTS IN THE HUB BENEFIT FROM CLEAR IP FRAMEWORK AND IP SUPPORT SERVICES, STREAMLINING TECHNOLOGY TRANSFER, COMMERCIALIZATION, AND LICENSING. COMMUNITY MEMBERS AND STUDENTS ACCESS INCREASE LEARNING OPPORTUNITIES, PROGRAMMING, AND INTERNSHIP / CO-OP OPPORTUNITIES. SUBRECIPIENT ACTIVITIES: ROCHESTER INSTITUTE OF TECHNOLOGY, UNIVERSITY OF ROCHESTER, CORNELL UNIVERSITY, AND UNIVERSITY OF BUFFALO WILL SUPPORT THE ACTIVITIES INCLUDED IN THIS PROJECT, INCLUDING DEVELOPING THE INNOVATION ASSET/EXPERTISE ENGAGEMENT NETWORK, BUILDING OUT KNOWLEDGE/IP COLLABORATION ARCHITECTURE, AND CREATING A FORMAL COMMUNITY OF PRACTICE IN THE TECH HUB.

LEADERS FOR DEMOCRACY FELLOWSHIPS PROGRAM IS A FOUR-MONTH PROGRAM THAT WILL PROVIDE 25 EMERGING DEMOCRACTIC REFORM LEADERS BETWEEN THE AGES OF 25 AND

NATIONAL INSTITUTE ON DISABILITY AND REHABILITATION RESEARCH - DISABILITY AND REHABILITATION RESEARCH PROJECTS

SOUTHEAST ADA CENTER HHS REGION 4

SOUTHEAST ADA CENTER - HHS REGION 4

SPIN DEPENDENT PHENOMENA IN MEDIUM ENERGY PHYSICS

REHABILITATION CONTINUING EDUCATION PROGRAM

GRANT

INTEGRATED WHOLE-BUILDING ENERGY EFFICIENCY RETROFIT SOLUTION FOR RESIDENCES IN COLD/VERY COLD CLIMATES

AWARD TYPE: PROJECT GRANT; ACTIVITIES TO BE PERFORMED: PROVIDE HIGH QUALITY SUPPORT AND TECHNICAL ASSISTANCE WITH PANDEMIC RELIEF PROGRAMS AND RECOVERY SERVICES TO SMALL BUSINESSES.; DELIVERABLES: GRANTEES WILL PROVIDE REPORTS ON ACTIVITIES AND PROGRESS TOWARD STATED GOALS TO SBA ON A QUARTERLY BASIS.; EXPECTED OUTCOMES: INCREASE AWARENESS OF AND PARTICIPATION IN PROGRAMS OF THE U.S SMALL BUSINESS ADMINISTRATION AND OTHER GOVERNMENT AGENCIES.; INTENDED BENEFICIARIES: SMALL BUSINESSES AND ENTREPRENEURS THAT FALL INTO A HISTORICALLY UNDERSERVED CATEGORY, INCLUDING MINORITY ENTREPRENEURS (BLACK, INDIGENOUS, AND PEOPLE OF COLOR), ENTREPRENEURS WITH DISABILITIES, LGBTQ ENTREPRENEURS, RURAL ENTREPRENEURS; VETERANS AND MILITARY ENTREPRENEURS (INCLUDING SPOUSES), WOMEN ENTREPRENEURS, INNOVATIVE STARTUPS, MICRO BUSINESSES, AND SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESSES; SUBRECIPIENT ACTIVITIES: GRANTEES (HUBS) AND THEIR CONTRACTORS (SPOKES) WILL PROVIDE HIGH QUALITY SUPPORT AND TECHNICAL ASSISTANCE WITH PANDEMIC RELIEF PROGRAMS AND RECOVERY SERVICES TO SMALL BUSINESSES. THIS SUPPORT TAKES THE FORM OF 1:1 COUNSELING AND GROUP TRAININGS.

TAS::89 0328::TAS RECOVERY OE - WORKFORCE TRAINING FOR THE ELECTRIC POWER SECTOR. NEW FY10 AWARD SELECTED UNDER FOA #DE-FOA-0000152

COLLABORATIVE RESEARCH: CONSTRUCTION OF THE UPSTREAM TRACKER FOR THE LHCB UPGRADE

DESCRIPTION:THE AGREEMENT PROVIDES FUNDING TO SYRACUSE UNIVERSITY TO IMPLEMENT ITS PROJECT TO PROVIDE DIRECT TECHNICAL ASSISTANCE TO HELP UNDER-RESOURCED AND UNDER-REPRESENTED MUNICIPALITIES, NATIVE NATIONS, AND WATER UTILITIES ACCESS FEDERAL AND STATE FUNDING, INCLUDING BI-PARTISAN INFRASTRUCTURE LAW (BIL) FUNDING, FOR PROJECTS THAT ADDRESS CLEAN AND SAFE WATER RESOURCES. SYRACUSE UNIVERSITY AND ITS PARTNER'S CAPACITY BUILDING AND TRAINING WILL INCREASE TECHNICAL, MANAGERIAL, AND FINANCIAL COMPETENCIES OF COMMUNITY LEADERS, AND UTILITY STAFF TO PROVIDE CLEAN AND SAFE WATER. THE EFCS PROVIDE FINANCE-RELATED TRAINING, EDUCATION, AND ANALYTICAL STUDIES TO HELP REGULATED PARTIES DEVELOP SOLUTIONS TO THE DIFFICULT 'HOW-TO-PAY' ISSUES ASSOCIATED WITH MEETING ENVIRONMENTAL STANDARDS. THE EFCS EDUCATE STATE, TRIBAL, AND LOCAL GOVERNMENTS AND BUSINESSES ON LOWERING ENVIRONMENTAL COSTS, INCREASING ENVIRONMENTAL INVESTMENTS, IMPROVING FINANCIAL CAPACITY, IDENTIFYING APPROPRIATE REVENUE GENERATING MECHANISMS, AND EVALUATING ENVIRONMENTAL FINANCING OPTIONS.ACTIVITIES:THE ACTIVITIES TO BE PERFORMED ARE IDENTIFYING AND ENGAGING COMMUNITIES IN REGION 2 TO RECEIVE TECHNICAL ASSISTANCE WITH A FOCUS ON UNDERSERVED POPULATIONS; DELIVERING DIRECT TECHNICAL ASSISTANCE TO HELP UNDERSERVED COMMUNITIES ACCESS FUNDING TO IMPLEMENT WATER INFRASTRUCTURE IMPROVEMENTS; SHARING FEEDBACK WITH STATE FINANCING PROGRAM MANAGERS TO IMPROVE ACCESS TO THEIR PROGRAMS, ESPECIALLY FOR DISADVANTAGED COMMUNITIES; DEVELOPING AND DELIVERING BROAD-REACHING CAPACITY DEVELOPMENT, TRAINING, TOOLS AND RESOURCES TO HELP COMMUNITIES ACCESS FUNDING FOR WATER INFRASTRUCTURE IMPROVEMENTS; AND FORMING AN ADVISORY COMMITTEE TO GUIDE THE TEAM'S EQUITABLE APPROACH TO IDENTIFYING AND ASSISTING HUNDREDS OF COMMUNITIES IN REGION 2.SUBRECIPIENT:THE SUBWAWARD RECIPIENTS AND THE ACTIVITIES THEY WILL BE IMPLEMENTING THROUGH THE SUBAWARDS ARE LISTED BELOW. CORNELL UNIVERSITY WILL WORK ACROSS ALL PROJECT TASKS, ENGAGE AND LEVERAGE STUDENTS IN TECHNICAL ASSISTANCE AND TRAINING ACTIVITIES, INCLUDING AGUACLARA REACH, DEVELOP NEW AND/OR SYNTHESIZE EXISTING RESOURCES SPECIFIC TO WATER INFRASTRUCTURE INVESTMENT, TRANSLATING FOR APPROPRIATE AUDIENCES, AND SUPPORT DEVELOPMENT OF TOOLS, TRAINING, AND PUBLICATIONS. RCAP SOLUTIONS NORTHEAST/RSOL WILL PROVIDE TECHNICAL ASSISTANCE DIRECTLY TO COMMUNITIES IN REGION 2. AS THE NORTHEAST AFFILIATE OF RCAP SOLUTIONS, RSOL'S TEAM WILL HELP IDENTIFY AND INITIATE PROJECTS, PROVIDE ASSISTANCE ACROSS TA CATEGORIES, AND WORK WITH SU-EFC TO COORDINATE TRAININGS AND DEPLOY TOOLS. MOONSHOT MISSIONS WILL SERVE AS IN-HOUSE ENGINEERING ADVISOR AND PROJECT MANAGER TO COMMUNITIES RECEIVING DIRECT TA, AND PROVIDE TECHNICAL OVERSIGHT AND VALUE ENGINEERING SUPPORT NEW JERSEY FUTURE (NJF) WILL ACT AS LIAISON TO NJ COMMUNITIES FOR ASSISTANCE SERVICES, PROVIDE SUPPORT AND COORDINATION FOR TRAINING EVENTS, AND FORUMS. OUTCOMES:THE ANTICIPATED DELIVERABLES ARE CUSTOMIZED TECHNICAL ASSISTANCE, TRAINING EVENTS TO ADDRESS KNOWLEDGE AND TECHNICAL GAPS IN ORDER TO ACCESS WATER INFRASTRUCTURE FUNDING, AND DEVELOPMENT OF GUIDES, PUBLICATIONS, AND CASE STUDIES THAT WILL ALSO FACILITATE THE EXCHANGE OF BEST PRACTICES AND SUCCESSFUL MODELS BETWEEN COMMUNITIES, AGENCIES, AND PRACTITIONERS. THESE DELIVERABLES ARE EXPECTED TO LEAD TO PROVIDING DIRECT ENGAGEMENT WITH COMMUNITIES SO THEY CAN MEET FUNDING REQUIREMENTS AND SUBMIT CLEAR, WELL-DEVELOPED APPLICATIONS WHICH WILL INCREASE THE NUMBER OF REGULATED COMMUNITIES APPLYING FOR INFRASTRUCTURE FUNDING, COMPLETING OR UPDATING REQUISITE PLANS, ENVIRONMENTAL REVIEWS, ENGINEERING REPORTS, AND LEAD INVENTORIES; AND COMPLYING WITH CLEAN AND SAFE WATER REGULATIONS FOR UNDERSERVED MUNICIPALITIES, NATIVE NATIONS, AND WATER SYSTEMS ACCESS FEDERAL AND STATE FUNDING FOR PROJECTS THAT ADDRESS CLEAN AND SAFE WATER WHILE PREPARING THEM FOR CLIMATE-RELATED HAZARDS. THE EXPECTED OUTCOMES IS TO ALLOW MORE COMMUNITIES TO GET ON

REHABILITATION RESEARCH & TRAINING ON EMPLOYMENT POLICY: CENTER FOR DISABILITY-INCLUSIVE EMPLOYMENT POLICY RESEARCH

THEORETICAL PARTICLE PHYSICS AND COSMOLOGY

NEW PHYSICS WITH PRECISION MEASUREMENTS OF B AND C QUARKS AT LHCB

UPSTATE NEW YORK LSAMP: STRENGTHENING THE PIPELINE BETWEEN TWO AND FOUR YEAR INSTITUTIONS

NEW INTERACTIONS AND NEW PARTICLES WITH LHCB

ENGINEERED NANOPORES FOR SINGLE-MOLECULE STOCHASTIC SENSING

DISABILITY REHABILITATION RESEARCH PROJECTS

THE LEADERS FOR DEMOCRACY FELLOWSHIP PROGRAM PROVIDES EDUCATION, EXPERIENTIAL TRAINING, AND ALUMNI NETWORKING IN THE U.S. AND MENA REGION.

THE INCLUSIVE CONNECTIVE CORRIDOR: SOCIAL NETWORKS AND THE ADVANCEMENT OF WOMEN STEM FACULTY

MICRO ENVIRONMENTAL CONTROL SYSTEM

INTENSITY FRONTIER PHYSICS STUDIES WITH B AND C QUARKS AT LHCB

NEW PERSPECTIVES ON BEAUTY AND CHARM QUARKS AT LHCB: PHYSICS STUDIES, COMPUTING, AND INSTRUMENTATION FOR A NEW CHAPTER IN FLAVOR PHYSICS -THIS AWARD WILL FURTHER EXPLORE NEW PHYSICS AT THE LHCB EXPERIMENT AT CERN. THE WORK WILL CONTINUE DEVELOPING THE DETECTOR AND ALGORITHMS THAT COULD LEAD TO NEW DISCOVERIES IN B PHYSICS THAT COULD SHED LIGHT ON FUNDAMENTAL QUESTIONS SUCH AS WHY THE UNIVERSE IS DOMINATED BY MATTER RATHER THAN ANTIMATTER. THIS WORK BUILDS ON THE ONGOING WORK OF THE SYRACUSE GROUP ON THE UPSTREAM TRACKER (UT), A KEY COMPONENT OF THE LHCB EXPERIMENT. THIS UT PLAYS A CRUCIAL ROLE IN IDENTIFYING B QUARKS IN THE COLLISIONS AT LHCB. THE GROUP IS DEVELOPING MACHINE LEARNING AND ARTIFICIAL INTELLIGENCE TO FURTHER REFINE THE IDENTIFICATION PROCESS IN THIS B-QUARK ANALYSIS. THIS AWARD WILL ALSO PROVIDE R&D FOCUSED ON THE ELECTRONICS THAT OPTIMIZE THE PERFORMANCE OF THE NEW CALORIMETER CONSIDERED FOR THE LAST CHAPTER OF LHCB TO FULLY EXPLOIT THE UNIQUE OPPORTUNITIES OF THE HL-LHC. THIS INSTRUMENTATION WORK SUPPORTS THE TECHNOLOGICAL LEADERSHIP OF THE US, WHICH ULTIMATELY IS ALSO A STRONG FACTOR IN ENSURING OUR NATIONAL SECURITY. THIS GROUP WILL ALSO WORK ON THE EDUCATION OF THE NEXT GENERATION OF STEM PROFESSIONALS, THOROUGHLY ALIGNED WITH THE GOALS OF PROMOTING NATIONAL HEALTH, PROSPERITY, AND WELFARE. THE TEAM INCLUDES UNDERGRADUATE, GRADUATE, AND POST-DOCTORAL RESEARCH ASSOCIATES. IN ADDITION, THEY WILL ENGAGE HIGH-SCHOOL STUDENTS FROM CITY SCHOOLS IN SUMMER INTERNSHIPS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

BEAUTY AT LHCB, CHARM AT CLEO-C

NRT: EDUCATION MODEL PROGRAM ON WATER-ENERGY RESEARCH (EMPOWER) AT SYRACUSE UNIVERSITY

V-WISE & OPERATION ENDURE AND GROW

RESEARCH AT THE INTENSITY FRONTIER WITH THE LHCB EXPERIMENT

LSAMP PHASE I: THE UPSTATE ALLIANCE

LEADERS FOR DEMOCRACY FELLOWSHIP

BOOTS TO BUSINESS TRAINING PROGRAM (B2B)

BOOTS TO BUSINESS TRAINING PROGRAM (B2B)

THE MBDA CAPITAL READINESS PROGRAM (PROGRAM) IS DESIGNED TO HELP CLOSE THE ENTREPRENEURSHIP GAP BETWEEN SOCIALLY AND ECONOMICALLY DISADVANTAGED INDIVIDUALS (SEDI) AND NON-SEDI. THE RECIPIENTS ARE WERE SELECTED TO: (1) HELP SEDI ENTREPRENEURS BUILD CAPACITY; (2) ATTRACT AND PROVIDE ACCESS TO CAPITAL OPPORTUNITIES; AND (3) ATTRACT AND PROVIDE ACCESS TO NETWORKS. THE PROPOSED ACTIVITIES MAY RESEMBLE THE SERVICE MODELS OF INCUBATORS (FOCUSING ON EARLY-STAGE TECHNICAL ASSISTANCE FOR NEW ENTREPRENEURS) OR ACCELERATORS (PROVIDING EMERGING-STAGE TECHNICAL ASSISTANCE TO BUSINESSES READY TO EXPAND OR SCALE), OR PROVIDE A COMBINATION OF BOTH SERVICE MODELS.

NRT-UROL: EMERGENT INTELLIGENCE RESEARCH FOR GRADUATE EXCELLENCE IN BIOLOGICAL AND BIO-INSPIRED SYSTEMS (EMIRGE-BIO) -MANY OF OUR SOCIETY?S MOST PRESSING CHALLENGES ? INCLUDING FOOD SECURITY, SUSTAINABILITY, AND SUPPORTING AGING POPULATIONS ? WILL REQUIRE BREAKTHROUGHS IN BIOTECHNOLOGY AND BIO-INSPIRED SCIENCE. THIS NATIONAL SCIENCE FOUNDATION RESEARCH TRAINEESHIP (NRT) AWARD TO SYRACUSE UNIVERSITY WILL TRAIN A NEW GENERATION OF SCIENTISTS AND ENGINEERS WHO CAN EVALUATE AND HARNESS COMPLEX SYSTEMS, SUCH AS BIOLOGICAL TISSUES OR NEXT-GENERATION MATERIALS, TO DRIVE INTELLIGENT RESPONSES SUCH AS SENSING, ACTUATING, AND LEARNING, LEADING TO BREAKTHROUGH TECHNOLOGIES. THE PROJECT ANTICIPATES TRAINING 115 PHD STUDENTS, INCLUDING 37 FUNDED TRAINEES, FROM FIELDS THAT SPAN THE LIFE AND PHYSICAL SCIENCES AND ENGINEERING. THE INNOVATIVE, TEAM-BASED CURRICULUM AND RESEARCH PROGRAM WILL BUILD STEM WORKFORCE CAPACITY BY TRAINING PEOPLE WHO THRIVE ON HIGH-PERFORMING INTERDISCIPLINARY TEAMS, WHERE EACH MEMBER OF THE TEAM CONTRIBUTES UNIQUE AND DEEP DISCIPLINARY EXPERTISE WHILE STILL COMMUNICATING THEIR KNOWLEDGE ACROSS A DIVERSE TEAM TO DRIVE DISCOVERIES NOT POSSIBLE WITHIN A SINGLE DISCIPLINE. THIS PROJECT WILL TRAIN PH.D. STUDENTS TO IDENTIFY AND CHARACTERIZE EMERGENT BEHAVIORS THROUGH SEVERAL APPLICATIONS THAT CROSS-CUT BIOLOGY AND MATERIALS DESIGN. SINCE BIOLOGICAL ORGANISMS HARNESS THE EMERGENT BEHAVIOR OF COMPONENTS AT SMALL SCALES TO GENERATE INTELLIGENT STRUCTURES THAT PERFORM TASKS AT LARGE SCALES, SIMILAR PRINCIPLES CAN BE USED TO DESIGN NEW INTELLIGENT MATERIALS AND DEVICES. THE PROGRAM CURRICULUM SUPPORTS THE INTERACTION BETWEEN BIOLOGY AND MATERIAL DESIGN FIELDS BY FIRST TRAINING STUDENTS IN CORE DISCIPLINARY COMPETENCIES, THEN PROVIDING EXPLICIT CURRICULAR TRAINING IN INTERDISCIPLINARY TEAM BUILDING VIA THE EVIDENCE-DRIVEN ?TEAM-BASED LEARNING? PARADIGM, AND ULTIMATELY ENGAGING STUDENTS ON RESEARCH TEAMS WITH WORLD-EXPERT FACULTY FROM DIVERSE DISCIPLINARY BACKGROUNDS. THESE TEAMS WILL APPROACH DIFFICULT PROBLEMS FROM NEW PERSPECTIVES AND TRANSFER USEFUL TOOLS AND TECHNIQUES BETWEEN THE LIFE SCIENCES AND MATERIALS DESIGN. THE PROJECT ALSO PROVIDES LONGITUDINAL ENTREPRENEURSHIP TRAINING SO THAT STUDENTS ARE ABLE TO COMMERCIALIZE THEIR DISCOVERIES AND WORK IN INDUSTRIAL SETTINGS. THIS TRAINING WILL HELP STUDENTS BRING THEIR RESEARCH DISCOVERIES TO MARKET TO HELP ADDRESS GRAND SOCIETAL CHALLENGES SUCH AS THOSE IN SUSTAINABILITY AND HEALTHCARE. THE PROJECT WILL ALSO HAVE IMPACT BEYOND THE LOCAL WORKFORCE, BY IMPLEMENTING, ASSESSING, AND DISSEMINATING A SUCCESSFUL CURRICULUM FOR TRAINING STUDENTS IN TEAM-BASED RESEARCH FOCUSED ON EMERGENT INTELLIGENCE. THE NSF RESEARCH TRAINEESHIP (NRT) PROGRAM IS DESIGNED TO ENCOURAGE THE DEVELOPMENT AND IMPLEMENTATION OF BOLD, NEW POTENTIALLY TRANSFORMATIVE MODELS FOR STEM GRADUATE EDUCATION TRAINING. THE PROGRAM IS DEDICATED TO EFFECTIVE TRAINING OF STEM GRADUATE STUDENTS IN HIGH PRIORITY INTERDISCIPLINARY OR CONVERGENT RESEARCH AREAS THROUGH COMPREHENSIVE TRAINEESHIP MODELS THAT ARE INNOVATIVE, EVIDENCE-BASED, AND ALIGNED WITH CHANGING WORKFORCE AND RESEARCH NEEDS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

IGERT: SOFT INTERFACES - BRIDGING THE DIVIDE IN GRADUATE EDUCATION (IBRID)

INCLUDING ADULTS WITH INTELLECTUAL DISABILITY IN PRECISION MEDICINE RESEARCH - PROJECT ENGAGE - ABSTRACT PRECISION MEDICINE RESEARCH (PMR) HOLDS POTENTIAL TO TRANSFORM HEALTH BY UNEARTHING GENETIC AND NON-GENETIC MECHANISMS OF DISEASE AND DEVELOPING TAILORED PREVENTION AND TREATMENT. PARTICIPATION OF ADULTS WITH INTELLECTUAL DISABILITY IN PMR OFFERS NEW OPPORTUNITIES TO ADDRESS THEIR SUBSTANTIAL HEALTH DISPARITIES. YET EFFORTS TO IDENTIFY THEIR UNIQUE NEEDS FOR INCLUSION AND ENGAGEMENT IN PMR HAVE BEEN LACKING. DESPITE EVIDENCE THAT MOST ADULTS WITH INTELLECTUAL DISABILITY DEMONSTRATE CONSENT CAPACITY, PRECISION MEDICINE (PM) RESEARCHERS MAY EXCLUDE THEM, FAIL TO ACCOMMODATE THEIR UNIQUE NEEDS IN DECISION-MAKING, OR USE PROXY CONSENT WITH LITTLE MEANINGFUL ASSENT. CONSENT OF ADULTS WITH INTELLECTUAL DISABILITY TO PMR FURTHER RAISES NOVEL CONCERNS, INCLUDING BEST MODELS FOR CONSENT AND HOW TO MANAGE THE RETURN OF GENETIC RESULTS WHILE ALSO ASSURING GENOMIC PRIVACY AND PROMOTING INCLUSION AND EMPOWERMENT—BELIEVED TO BE CRITICAL FOR SUCCESSFUL PMR. UNFORTUNATELY, MANY PM RESEARCHERS FEEL ILL-EQUIPPED TO RESPOND; THEY EXPRESS DESIRE FOR EDUCATIONAL AND PRACTICAL RESOURCES THAT ARE NOT CURRENTLY AVAILABLE. THESE GAPS CONTRIBUTE TO ADULTS WITH INTELLECTUAL DISABILITY BEING UNDERSTUDIED AND CREATE BARRIERS TO GENERATING KNOWLEDGE TO ADDRESS THEIR HEALTH NEEDS. THEY ALSO IMPEDE EMPOWERMENT AND ARE INCREASINGLY ETHICALLY QUESTIONABLE: ADULTS WITH INTELLECTUAL DISABILITY WANT TO BE INCLUDED IN PMR. THE PROPOSED STUDY EMPLOYS AN ACADEMIC-COMMUNITY PARTNERSHIP TO CLOSE THESE GAPS BY: (1) CONDUCTING A NATIONAL, DISABILITY-TAILORED SURVEY WITH ADULTS WITH INTELLECTUAL DISABILITY TO IDENTIFY PREFERENCES REGARDING DECISION-MAKING ROLE, COMMUNICATION OF RESULTS, GENOMIC PRIVACY, AND NEEDS FOR ENGAGEMENT IN PMR; (2) CREATING A PMR STUDY-ADAPTABLE CONSENT TOOLKIT TO SUPPORT PM RESEARCHERS IN INCLUDING ADULTS WITH INTELLECTUAL DISABILITY IN PMR AND EMPIRICALLY TEST IT VIA A TEXT COMPLEXITY STUDY AND COGNITIVE INTERVIEWS WITH ADULTS WITH INTELLECTUAL DISABILITY TO ENSURE UNDERSTANDABILITY TO THIS POPULATION; AND (3) CONDUCTING A SOCIAL VALIDITY STUDY WITH PM RESEARCHERS TO ASSESS THE TOOLKIT’S USABILITY, RELEVANCE, ACCEPTABILITY, AND COMPREHENSIVENESS. THE WEB-BASED CONSENT TO PMR TOOLKIT WILL BE FREELY AVAILABLE. WE WILL DISSEMINATE OUR FINDINGS THROUGH WORKSHOPS, WEBINARS, PEER-REVIEWED PUBLICATIONS, AND PRESENTATIONS AT PROFESSIONAL MEETINGS. PMR HAS STIRRED HOPES FOR A NEW, SCIENTIFICALLY-BASED, AND EMPOWERING HEALTHCARE MODEL THAT REACHES, AND CAN BENEFIT, THOSE WHO ARE MOST VULNERABLE AND EXPERIENCE SUBSTANTIAL HEALTH DISPARITIES. THIS PROJECT HAS THE POTENTIAL TO TRANSFORM PMR BY HELPING PM RESEARCHERS AVOID THE PITFALLS OF BIAS, UPHOLD PRINCIPLES OF HUMAN AGENCY VALUED BY COMMUNITY MEMBERS, DEPLOY STRATEGIES TO FURTHER GROW AND DIVERSIFY EXISTING PMR DATASETS. THIS WORK WILL, OVER TIME, HELP FOSTER PRACTICES IN PMR THAT PROMOTE EQUITABLE HEALTHCARE—NIH PRIORITIES. THIS RESEARCH IS THE FIRST-TIME MULTIPLE STAKEHOLDERS INCLUDING ADULTS WITH INTELLECTUAL DISABILITY WILL COLLABORATE TO USE EMPIRICAL ETHICS INQUIRY TO ADDRESS CONSENT AND OTHER CHALLENGES IN PMR AND WILL YIELD CRITICAL THEORETICAL AND PRACTICAL INSIGHTS TO PMR INCLUSIVE OF ADULTS WITH INTELLECTUAL DISABILITY.

IL1 AND HYPOXIC-ISCHEMIC INSULTS

GAINING EARLY AWARENESS AND READINESS FOR UNDERGRADUATE PROGRAMS (GEAR-UP) - GEAR-UP

DISABILITY AND REHABILITATION RESEARCH PROGRAM

LSAMP MID-LEVEL: THE UPSTATE ALLIANCE

NATIONAL INSTITUTE ON DISABILITY AND REHABILITATION RESEARCH - DISABILITY AND REHABILITATION RESEARCH PROJECTS

UNDERSTANDING AND INCREASING SUPPORTED DECISION-MAKING A POSITIVE IMPACT ON COMMUNITY LIVING AND PARTICIPATION OUTCOMES

THE EFFECTS OF THE COVID-19 PANDEMIC ON LONG-TERM CARE FOR HIGH-NEED OLDER ADULTS WITH AND WITHOUT ALZHEIMER?S DISEASE AND RELATED DEMENTIAS - PROJECT SUMMARY NEARLY 20 MILLION ADULTS (38%) AGED 65 AND OLDER HAVE LIMITATIONS WITH ONE OR MORE SELF-CARE ACTIVITIES (E.G., DRESSING, GETTING OUT OF BED) AND ONE IN TEN OLDER ADULTS ARE LIVING WITH ALZHEIMER’S DISEASE AND RELATED DEMENTIAS (ADRD). TOGETHER THESE TWO OVERLAPPING GROUPS OF “HIGH-NEED” OLDER ADULTS TYPICALLY RELY ON A VARIETY OF LONG-TERM CARE (LTC) SOURCES TO ASSIST WITH DAILY ACTIVITIES, INCLUDING FAMILY AND UNPAID CARE, PAID CARE IN THE HOME, RESIDENTIAL CARE SUCH AS ASSISTED LIVING AND NURSING HOME CARE. INADEQUATE CARE MAY LEAD TO ADVERSE CONSEQUENCES IN DAILY SELF-CARE AND AVOIDABLE HEALTH CARE UTILIZATION. THE SUDDEN ONSET OF THE COVID- 19 PANDEMIC MAY HAVE PROFOUNDLY AFFECTED ACCESS TO AND USE OF LTC AND CONTRIBUTED TO FURTHER ADVERSE CONSEQUENCES FOR HIGH-NEED OLDER ADULTS, PARTICULARLY FOR THOSE LIVING WITH ADRD. THIS PROJECT WILL DRAW UPON TWO COMPLEMENTARY LONGITUDINAL, NATIONALLY REPRESENTATIVE SURVEYS OF OLDER ADULTS–THE HEALTH AND RETIREMENT STUDY (HRS) AND THE NATIONAL HEALTH AND AGING TRENDS STUDY (NHATS)–LINKED TO GEOGRAPHIC DATA AND MEDICARE CLAIMS. USING STATISTICAL APPROACHES THAT STRENGTHEN OUR ABILITY TO DRAW CAUSAL INFERENCES, WE WILL: 1) EVALUATE THE SHORT-TERM IMPACT (2018-2020) OF THE COVID-19 PANDEMIC ON THE TYPE AND AMOUNT OF LTC USE, COMPARING HIGH-NEED OLDER ADULTS WITH AND WITHOUT ADRD AND IDENTIFY ARRANGEMENTS MORE LIKELY TO BE “STABLE” WITH LOWER RISKS OF CHANGE. 2) DETERMINE WHETHER CARE TRAJECTORIES WERE DISRUPTED AFTER THE START OF THE PANDEMIC, COMPARING HIGH-NEED OLDER ADULTS WITH AND WITHOUT ADRD FROM 2016 THROUGH 2024/2025. 3) ASSESS THE IMPACT OF COVID-19 ON ADVERSE CONSEQUENCES RELATED TO CARE GAPS AMONG HIGH-NEED OLDER ADULTS WITH AND WITHOUT ADRD. WE WILL ESTIMATE THE EFFECT OF THE COVID-19 PANDEMIC ON SELF-REPORTS OF UNMET NEED (USING NHATS) AND CLAIMS-BASED MEASURES OF AVOIDABLE HOSPITALIZATIONS AND EMERGENCY DEPARTMENT VISITS (USING HRS) FOR THOSE WITH AND WITHOUT ADRD. DETAILED GEOGRAPHIC DATA WILL ALLOW US TO TAKE INTO ACCOUNT LOCAL CONDITIONS WHILE IDENTIFYING MORE “VULNERABLE” CARE ARRANGEMENTS WITH HIGHER RISKS OF ADVERSE CONSEQUENCES. THE RESULTS OF THIS PROJECT WILL PROVIDE A COMPREHENSIVE UNDERSTANDING OF THE COVID-19 PANDEMIC’S IMPACT ON LTC OUTCOMES IN THE SHORT AND LONGER TERM. THIS STUDY ALIGNS WITH NIA’S PRIORITY TO UNDERSTAND COMMUNITY SUPPORT FOR DEMENTIA CARE, IN PARTICULAR THE DETERMINANTS OF AVAILABILITY LTC, LTC UTILIZATION AND HOW THE EFFECTS OF COMMUNITY LEVEL FACTORS INCLUDING INFRASTRUCTURE AND RISK ENVIRONMENT.

MEDIUM ENERGY PHYSICS

SCALING-UP PROJECT CRITICAL: CURRICULUM RESTRUCTURING, IN-SERVICE TRAINING,IDENTIFICATION, COMPUTER APPLICATIONS, AND LEARNING OUTCOMES

ALCOHOL AND IMPLICIT PROCESS IN SEXUAL RISK BEHAVIOR IN MSM

RESEARCH PROGRAM IN ELEMENTARY PARTICLE THEORY

EFRI-MIKS: DECIPHERING AND CONTROLLING THE SIGNALING PROCESSES IN BACTERIAL MULTICELLULAR SYSTEMS AND BACTERIA-HOST INTERACTIONS

DISABILITY REHABILITATION RESEARCH PROJECTS

ESTABLISHING AN IN VITRO EMBRYOTOXICITY RISK CLASSIFICATION SYSTEM BASED ON HUMAN CARDIAC ORGANOID MODEL

SCALABLE READOUT OF SUPERCONDUCTING QUBITS WITH NOVEL SUPERCONDUCTING AMPLIFIERS AND METAMATERIALS

PROJECT IMMERSE (INCLUSIVE, MULTICULTURAL, MULTILINGUAL, EFFECTIVE AND RESPONSIVE SPECIAL EDUCATION)

DISABILITY AND REHABILITATION RESEARCH PROGRAM: THE COMMUNITY FOR ALL PROJECT

CENTER FOR AGING AND POLICY STUDIES

THE CELLULAR ENVIRONMENT AS A REGULATOR OF INTRINSICALLY DISORDERED PROTEINS

STUDENT SUPPORT SERVICES 2020 – 2025

FOUR-DIMENSIONAL PREDICTION AND QUANTIFICATION OF HOW PHYSICAL FORCES IMPACT ORGANOGENESIS IN ZEBRAFISH

ROLE OF VIMENTIN IN MAMMALIAN CELL MOTILITY - ABSTRACT CELL MIGRATION IS ESSENTIAL TO MANY FUNDAMENTAL PROCESSES, INCLUDING EMBRYONIC DEVELOPMENT, WOUND REPAIR, AND CANCER METASTASIS. CENTRAL TO THIS PROCESS IS THE CELLULAR CYTOSKELETON COMPRISED OF THREE POLYMERIC NETWORKS: F-ACTIN, MICROTUBULES, AND INTERMEDIATE FILAMENTS (IFS). VIMENTIN IS AN IF PROTEIN THAT IS ESSENTIAL TO THE MECHANICAL RESILIENCE OF CELLS AND REGULATES CROSS-TALK AMONGST THE CYTOSKELETON, BUT ITS ROLE IN HOW CELLS SQUEEZE THROUGH SMALL PORES IN TISSUES IS POORLY UNDERSTOOD. WE HAVE SHOWN THAT LOSS OF VIMENTIN ENHANCES CELL MOTILITY THROUGH THREE-DIMENSIONAL 3D MICRO-FLUIDIC CHANNELS AND PROTECTS THE NUCLEUS FROM DAMAGE DURING MIGRATION. VIMENTIN IS THOUGHT TO PLAY A DISTINCT ROLE IN THE TRANSFER OF FORCES FROM CELL SURFACE MATRIX ADHESIONS TO THE NUCLEAR SURFACE, BUT NEW EVIDENCE SUGGESTS THAT VIMENTIN MAY ALSO PLAY A MORE ACTIVE ROLE IN PERSISTENT CELL MOTILITY VIA ITS INTERACTIONS WITH ACTIN STRESS FIBER FORMATION AND MICROTUBULE POSITIONING. STILL, THE SPECIFIC MECHANISMS BY WHICH VIMENTIN ENABLES 3D MIGRATION THROUGH DENSE TISSUE REMAINS UNCLEAR. THIS PROJECT ADDRESSES THE OVERARCHING QUESTION: HOW DOES VIMENTIN INFLUENCE CYTOSKELETAL FUNCTIONS, ADHESIONS WITH THE EXTRACELLULAR MATRIX, AND CELL-CELL INTERACTIONS TO COORDINATE 3D CELL MIGRATION? TO ADDRESS THIS QUESTION, WE WILL PURSUE THREE SUB-PROJECTS. FIRST, WE WILL DETERMINE THE EFFECTS OF VIMENTIN IN CYTOSKELETAL- MEDIATED 3D CELL MOTILITY. SECOND, WE WILL IDENTIFY VIMENTIN’S ROLE IN INTEGRIN EXPRESSION AND FOCAL ADHESION ACTIVATION, AND THIRD, WE WILL IDENTIFY THE MECHANISMS BY WHICH VIMENTIN MEDIATES COLLECTIVE CELL MIGRATION THROUGH EXTRACELLULAR MATRIX NETWORKS. THESE STUDIES WILL BE CONDUCTED IN BOTH 2D AND 3D SETTINGS TO DEFINE HOW CHANGES IN THE CELLULAR ENVIRONMENT IMPACT THE CRITICAL DETERMINANTS OF CYTOSKELETAL POLYMERS IN CELL MOTILITY. WE EXPECTED THAT THESE PROJECTS WILL DETERMINE NEW FUNCTIONAL ROLES OF VIMENTIN IN CELL MIGRATION, WHICH HAS IMPORTANT IMPLICATIONS FOR UNDERSTANDING HEALTHY TISSUE MAINTENANCE AND DISEASES THAT PROGRESS BY THE MIGRATION OF CELLS THROUGH TISSUES.

THE NEUROPHYSIOLOGY OF SENSORY PROCESSING AND MULTISENSORY INTEGRATION IN ASD

INTENSIVE SPEECH MOTOR CHAINING TREATMENT AND ARTIFICIAL INTELLIGENCE INTEGRATION FOR RESIDUAL SPEECH SOUND DISORDERS - PROJECT SUMMARY/ABSTRACT SPEECH SOUND DISORDERS IMPACTING /, S, Z/ MAY BECOME CHRONIC DUE TO EITHER INEFFECTIVE OR LIMITED TREAT- MENT. THE LONG-TERM GOAL IS TO LEVERAGE THEORETICAL AND TECHNOLOGICAL ADVANCEMENTS TO ACCELERATE THE DEVELOP- MENT OF ACCESSIBLE AND EFFECTIVE TREATMENTS THAT MITIGATE REDUCED QUALITY OF LIFE DUE TO CHRONIC RESIDUAL SPEECH SOUND DISORDERS (RSSD). TO THIS END, THE VALIDATED MOTOR-BASED RSSD TREATMENT SPEECH MOTOR CHAINING GUIDES SPEECH-LANGUAGE PATHOLOGISTS (SLPS) THROUGH HIGH-FIDELITY, HIGH-TRIAL, RAPIDLY ADAPTING TREATMENT BY DOSING AND MANIPULATING SEVERAL PRINCIPLES OF MOTOR LEARNING IN REAL TIME. SLP-LED SPEECH MOTOR CHAINING HAS BEEN EFFECTIVE FOR INDIVIDUALS WHOSE ERRORS PERSIST AFTER TRADITIONAL TREATMENT. HOWEVER, AT LEAST TWO CHALLENGES REMAIN: FIRST, OPTIMAL TREATMENT INTENSITY IS UNKNOWN. SECOND, SLPS NEED VALIDATED AVENUES FOR EVIDENCE-BASED PRACTICE WHEN CASELOAD SIZE PRECLUDES OPTIMAL INTENSITY. THEREFORE, THE OVERALL OBJECTIVE OF THIS PROPOSAL IS TO OPTIMIZE A SUITE OF THEORETICALLY MOTIVATED, HIGH-FIDELITY, MOTOR-BASED TREATMENTS DELIVERED AT THE APPROPRIATE INTENSITY, DESPITE PRACTICAL BARRIERS, FOR THE SOUNDS COMPRISING 90% OF RSSD: /, S, Z/. THE CENTRAL WORKING HYPOTHESES, SUPPORTED BY OUR PRELIMINARY WORK, ARE THAT SPEECH MOTOR CHAINING IS (A) MORE EFFICACIOUS WHEN DELIVERED INTENSIVELY (I.E., CLOSELY SPACED FOR A FIXED NUMBER OF SESSIONS), AND (B) ALSO BENEFICIAL WHEN PRACTICE IS LED BY AN ARTIFICIAL INTELLI- GENCE (AI) SLP. THE THEORETICAL RATIONALE IS THAT INCREASING INTENSITY EARLY IN TREATMENT WILL MITIGATE ERRED PRAC- TICE BETWEEN SESSIONS, IMPROVING OUTCOMES RELATIVE TO MORE CUSTOMARY PRACTICE DISTRIBUTIONS, AND THAT RELIABLE AI-MEDIATED PRACTICE IS EFFECTIVE IN THE CONTEXT OF VALIDATED TREATMENTS. THERE ARE THREE AIMS: AIM 1: DETER- MINE HOW INTENSIVE/DISTRIBUTED TREATMENT AFFECTS SPEECH SOUND LEARNING IN RSSD. A RANDOMIZED CONTROLLED TRIAL (N=84) WILL TEST THE HYPOTHESIS THAT INTENSIVE SLP-LED SPEECH MOTOR CHAINING (I.E., BOOTCAMP) LEADS TO GREATER GAINS IN SPEECH SOUND ACCURACY COMPARED TO AN EQUIVALENT NUMBER OF CUSTOMARILY DISTRIBUTED SESSIONS. AIM 2: DETERMINE IMPROVEMENT IN // PRODUCTION WHEN SPEECH MOTOR CHAINING PRACTICE TRIALS ARE LED BY AN ARTIFICIAL INTELLIGENCE CLINICIAN. A MULTIPLE BASELINE SINGLE SUBJECT DESIGN WILL TEST THE HYPOTHESIS THAT CHAINING-AI, IN WHICH AN AI SLP PROVIDES CLINICAL FEEDBACK, FACILITATES CLINICALLY MEANINGFUL CHANGE IN // PRODUCTION. AIM 3: DEMONSTRATE BREADTH OF CLINICAL AI CAPABILITY BY OPTIMIZING MIS- PRONUNCIATION CLASSIFICATION ALGORITHMS FOR /S/ AND /Z/. MISPRONUNCIATION DETECTION ALGORITHMS WILL BE TRAINED TO RECOGNIZE CLINICAL SPEECH ERRORS AFFECTING /S/ AND /Z/, REPLICATING EXPERT LISTENER JUDGEMENT WITH CLINI- CALLY-ACCEPTABLE ACCURACY. THIS SIGNIFICANT RESEARCH ADDRESSES A CRITICAL NEED FOR THEORETICAL/EMPIRICAL GUIDANCE FOR TREATMENT INTENSITY, OFFERING SORELY NEEDED RECOMMENDATIONS IN A SYSTEM WHERE ~6 MILLION AMERICAN ADULTS HAVE UNRESOLVED RSSD. THIS INNOVATIVE RESEARCH ACCELERATES A PARADIGM SHIFT IN WHICH COMBINED SLP/AI SERVICE DELIVERY COULD OVERCOME BARRIERS TO EFFECTIVE, ACCESSIBLE, AND SUFFICIENTLY INTENSIVE TREATMENT, FOR 90% OF RSSD.

MECHANISMS OF LEFT RIGHT ORGANIZER DEVELOPMENT - SUMMARY STATEMENT IN VERTEBRATES, MOTILE CILIA WITHIN THE LEFT-RIGHT ORGANIZER (LRO) ARE PIVOTAL FOR A DEVELOPING ORGANISM’S LEFT RIGHT AXIS FORMATION, SUCH AS CARDIAC LEFT-RIGHT DEVELOPMENT. EVIDENCE FROM MODEL ORGANISMS, LIKE ZEBRAFISH LRO, HIGHLIGHTS CONSERVED CILIA-DRIVEN LEFTWARD FLOW CRUCIAL FOR REGULATING TARGET GENES CONTROLLING ASYMMETRIC HEART MORPHOGENESIS. LRO CELLS ARE MADE UP OF BOTH MOTILE AND NON-MOTILE CILIA WITH ONE POPULATION REQUIRED FOR FLUID FLOW GENERATION AND THE OTHER POTENTIALLY FOR FLUID SENSING. OPEN QUESTIONS THAT EXIST ARE: WHAT ARE THE MECHANISMS BY WHICH CELLS DETERMINE WHETHER TO DEVELOP MOTILE OR NON-MOTILE CILIA WITHIN AN LRO? WHAT ARE THE SPECIFIC ROLES PLAYED BY EACH OF THESE CILIA POPULATIONS IN DEVELOPMENT? HOWEVER, ANSWERING THESE QUESTIONS IN MAMMALIAN LRO DEVELOPMENT IS HINDERED BY TECHNICAL CHALLENGES, LIMITING REAL-TIME ANALYSIS OF SPATIAL CELL ARRANGEMENTS, CYTOSKELETAL CHARACTERIZATION, CILIA ASSEMBLY, AND TRANSCRIPTIONAL LANDSCAPE EXPLORATION. WE AIM TO ADDRESS THESE CHALLENGES USING DANIO RERIO (ZEBRAFISH) LRO TO TEST OUR HYPOTHESIS: SPATIAL AND TEMPORAL CELL DIVISION REGULATION GUIDES INTRACELLULAR AND CELLULAR REMODELING ESSENTIAL FOR LRO MATURATION AND FUNCTION. OUR R35 APPLICATION ENCOMPASSES TWO PROJECTS. PROJECT 1: ASSESSING THE IMPACT OF EACH LRO CELL DIVISION EVENT ON LRO DEVELOPMENT. HERE WE WILL INVESTIGATE CELL REDISTRIBUTION MECHANISMS AND THE DOMINANCE OF SPECIFIC PROGENITOR CELLS IN LRO FORMATION, ADDRESSING CELL LINEAGE AND CELL BEHAVIOR QUESTIONS. ADDITIONALLY, COMPREHENSIVE GENE EXPRESSION ANALYSIS ACROSS LRO DEVELOPMENTAL STAGES WILL IDENTIFY KEY GENES AND PATHWAYS GUIDING LRO DEVELOPMENT. WE WILL EMPLOY CELL TRACKING, MICROTUBULE LABELING WITH LASER ABLATION, AND TRANSCRIPTOMIC PROFILING TO UNDERSTAND MITOTIC EVENTS CRUCIAL FOR LRO DEVELOPMENT. PROJECT 2: CHARACTERIZING MECHANISMS INVOLVED IN MICROTUBULE PATTERN FORMATION AND REORGANIZATION DURING LRO DEVELOPMENT IN RELATION TO ACTIN REORGANIZATION, TIGHT AND ADHERENS JUNCTIONS, AND CILIA FORMATION. UTILIZING LIVE CELL IMAGING, MOLECULAR AND GENETIC MANIPULATIONS, ARRAY TOMOGRAPHY AND AI, WE WILL CHARACTERIZE LRO CILIA LOCALIZATION AND STRUCTURE AT ROSETTE AND LUMEN STAGES TO IDENTIFY MODELS FOR LRO DEVELOPMENT EVENTS AND FLUID FLOW SENSING. SUCCESS IN ADDRESSING OUR OUTLINED OBJECTIVES IN UNRAVELING THE TEMPORAL AND SPATIAL MECHANISMS COORDINATING CELL DIVISION, INTRACELLULAR REMODELING, GENE EXPRESSION, POLARITY FORMATION, JUNCTIONAL PROTEIN FORMATION, AND CILIA ULTRASTRUCTURE DURING LRO DEVELOPMENT WILL POSITION US TO DEFINE HOW AN LRO IS ASSEMBLED AND PROVIDE NOVEL MODELS THAT CAN BE TESTED FOR HOW OTHER CILIATED TISSUES DEVELOP.

DISSECT HUMAN PRIMORDIAL GERM CELL DEVELOPMENT USING STEM CELL MODELS - PROJECT SUMMARY PRIMORDIAL GERM CELLS (PGCS), THE PRECURSORS OF EGGS AND SPERM, ARE ESSENTIAL FOR HUMAN REPRODUCTION. A COMPREHENSIVE UNDERSTANDING OF THE MOLECULAR MECHANISMS UNDERLYING SPECIFICATION, MATURATION AND MIGRATION OF HUMAN PRIMORDIAL GERM CELLS (HPGCS) IS CRITICAL FOR ADVANCING INFERTILITY TREATMENTS, REGENERATIVE MEDICINE, AND POTENTIAL THERAPIES FOR GENETIC DISORDERS. MOST OF OUR CURRENT KNOWLEDGE ON MAMMALIAN GERMLINE BIOLOGY IS DERIVED FROM STUDIES USING LABORATORY MICE. HOWEVER, DUE TO THE UNIQUE TRANSCRIPTIONAL NETWORKS AND DEVELOPMENTAL PATHWAYS OF HPGCS, THE KNOWLEDGE FROM OTHER SPECIES CANNOT BE DIRECTLY EXTRAPOLATED. MOREOVER, PGCS EMERGE DURING THE EARLIEST STAGE OF EMBRYOGENESIS, UNDERGOING COMPLEX MORPHOGENESIS AND MIGRATION, WHICH PRESENTS SIGNIFICANT TECHNICAL CHALLENGES FOR IN VIVO TRACKING AND STUDY. THE OVERARCHING OBJECTIVE OF MY RESEARCH IS TO DEVELOP STEM CELL-BASED MODELING SYSTEMS THAT CLOSELY RECAPITULATE THE LANDMARKS OF HUMAN EMBRYONIC DEVELOPMENTAL PROCESSES, AND TO APPLY THESE SYSTEMS TO ELUCIDATE THE FUNDAMENTAL MECHANISMS GOVERNING HUMAN DEVELOPMENT. NOTABLY, OVER THE PAST FEW YEARS, I DEVELOPED A STEM CELL-BASED MICROFLUIDIC HUMAN EMBRYOID MODEL THAT FAITHFULLY RECAPITULATES THE EARLY DEVELOPMENT OF HUMAN EMBRYONIC SAC IN A HIGHLY CONTROLLABLE AND SCALABLE FASHION, WHEREIN THE EMERGENCE OF HPGCS MIRRORS THE MOLECULAR SIGNATURES AND DEVELOPMENTAL TRAJECTORIES OBSERVED IN VIVO. I ALSO RECENTLY DEVISED A NOVEL METHOD FOR DERIVING HPGC-LIKE CELLS (HPGCLCS) USING AN EMBRYONIC-LIKE CULTURE SYSTEM. THIS METHOD SIGNIFICANTLY SIMPLIFIES HPGCLC INDUCTION PROTOCOLS AND PROVIDES INSIGHTS INTO HOW THE NATIVE CELLULAR MICROENVIRONMENT FACILITATES HPGC SPECIFICATION. THE RESEARCH OBJECTIVES FOR THIS FIVE-YEAR PROJECT ARE TO INTEGRATE APPROACHES FROM DEVELOPMENTAL AND STEM CELL BIOLOGY, MICROENGINEERING, GENOME EDITING, AND BIOINFORMATICS TO UNCOVER THE FUNDAMENTAL MECHANISMS DRIVING EARLY HPGC SPECIFICATION AND MIGRATION. SPECIFICALLY, 1) LEVERAGING THE MICROFLUIDIC EMBRYOID PLATFORM, WE WILL GENERATE A NOVEL LINEAGE REPORTER LINE TO PERFORM LINEAGE TRACING ASSAYS ON HPGCLCS. THROUGH SINGLE-CELL RNA SEQUENCING AND FUNCTIONAL GENETIC STUDIES, WE AIM TO ELUCIDATE THE ORIGIN AND LINEAGE TRAJECTORY OF HPGCS. 2) WE WILL ESTABLISH A PGC-HINDGUT CO-DEVELOPMENT MODEL TO INVESTIGATE THE MATURATION AND MIGRATION OF HPGCS AFTER SPECIFICATION. WE ANTICIPATE THIS MODEL WILL YIELD INSIGHTS INTO THE MECHANISMS GOVERNING HPGC MIGRATION AND THE CELLULAR CROSSTALK BETWEEN HPGCS AND THE HINDGUT. 3) USING THE EMBRYOID AND PGC-HINDGUT CO-DEVELOPMENT MODELS, WE WILL SYSTEMATICALLY DISSECT THE ROLES OF WNT SIGNALING IN HPGC LINEAGE COMMITMENT AND MIGRATION. SUCCESSFUL COMPLETION OF THIS PROJECT WILL DEEPEN OUR KNOWLEDGE OF HUMAN GERMLINE BIOLOGY AND FACILITATE FUTURE RESEARCH ON HEREDITARY DISEASES AND REPRODUCTIVE MEDICINE.

CHARM PHYSICS AT CLEO-C, BEAUTY PHYSICS AT LHCB

TRANSITION AND POSTSECONDARY PROGRAMS FOR STUDENTS WITH INTELLECTUAL DISABILITIES (TPSID)

RESEARCH AND MENTORING ON ALCOHOL CLINICAL AND HUMAN LABORATORY RESEARCH

EXCITOTOXICITY AND INFLAMMATION

THE ALCOHOL-PAIN CONNECTION: MECHANISMS AND GENETIC/PSYCHOLOGICAL CORRELATES

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

STATES' COVID-19 MITIGATION POLICIES AND PSYCHOLOGICAL HEALTH, DRUG OVERDOSE, AND SUICIDE AMONG U.S. ADULTS - THE COVID-19 PANDEMIC AND THE MITIGATION POLICIES IT PROMPTED MAY HAVE HAD PROFOUND CONSEQUENCES FOR THE PSYCHOLOGICAL HEALTH OF U.S. ADULTS, INCLUDING THEIR RISK OF DYING FROM DRUG OVERDOSE AND SUICIDE. TO MITIGATE THE SPREAD OF COVID-19, SOME U.S. STATES ENACTED POLICIES LIKE STAY-AT-HOME ORDERS AND BUSINESS CLOSURES. TO MITIGATE ADVERSE ECONOMIC AND HEALTH EFFECTS, SOME STATES ENACTED POLICIES LIKE EVICTION MORATORIA AND EXTENDED UNEMPLOYMENT BENEFITS. THESE POLICIES MAY HAVE AFFECTED ADULTS’ PSYCHOLOGICAL HEALTH AND RELATED MORTALITY THROUGH SOCIAL ISOLATION, WORK-FAMILY CONFLICT, INTERPERSONAL STRAIN, ECONOMIC WELLBEING, EMPLOYMENT DISRUPTIONS, AND MORE. THE OVERARCHING OBJECTIVE OF THIS PROPOSAL IS TO RIGOROUSLY ASSESS HOW STATE-LEVEL COVID-19 MITIGATION POLICIES HAVE AFFECTED PSYCHOLOGICAL HEALTH AND RELATED MORTALITY FROM DRUG OVERDOSE AND SUICIDE AMONG WORKING AGE AND OLDER ADULTS. THE PROJECT IS SIGNIFICANT AND WILL HAVE A SUSTAINED IMPACT BECAUSE IT: 1) IDENTIFIES HOW STATES’ MITIGATION POLICIES AFFECT PSYCHOLOGICAL HEALTH AND MORTALITY IN BOTH THE SHORT AND LONGER- TERMS, 2) LEVERAGES ADULTS’ SELF-REPORTS OF HOW COVID-19 AND MITIGATION POLICIES AFFECTED THEIR LIVES AND PSYCHOLOGICAL HEALTH WITH COUNTY-LEVEL ADMINISTRATIVE DATA ON DRUG OVERDOSE AND SUICIDE MORTALITY, AND 3) EMPIRICALLY DEVELOPS MEANINGFUL COMPOSITE MEASURES OF STATE MITIGATION POLICIES TO ASSESS THEIR IMPACT ON PSYCHOLOGICAL HEALTH AND MORTALITY. THE PROJECT IS INNOVATIVE IN THAT IT: 1) USES AND EXTENDS NOVEL SURVEY DATA FROM WORKING-AGE ADULTS ON HOW THE PANDEMIC AND ITS MITIGATION POLICIES AFFECTED THEIR LIVES, 2) USES RECENTLY- DEVELOPED METHODS FOR ANALYZING LARGE CONTEXTUAL DATASETS CONTAINING HIGH-DIMENSIONAL AND CORRELATED DATA AND 3) FOCUSES ON THE IMPACTS OF POLICIES ON PSYCHOLOGICAL HEALTH AND RELATED CAUSES OF DEATH, SPECIFICALLY DRUG- OVERDOSES AND SUICIDES, IN THE SHORT AND LONGER TERMS. THE PROJECT WILL ACCOMPLISH ITS OBJECTIVE THROUGH THREE SPECIFIC AIMS. AIM 1 IDENTIFIES HOW U.S. STATES’ COVID-19 POLICIES ARE ASSOCIATED WITH ADULT PSYCHOLOGICAL HEALTH. IT USES A NEW, NATIONAL SURVEY OF U.S. ADULTS AGED 18-64 (NATIONAL WELLBEING SURVEY) CONDUCTED IN FEB/MAR 2021 BY PI MONNAT. USING ITS SELF-REPORTED DATA ON HOW COVID-19 HAS AFFECTED PEOPLE’S LIVES, WE WILL ASSESS: A) HOW STATES’ COVID-19 POLICIES PREDICT INDIVIDUALS’ PSYCHOLOGICAL HEALTH APPROXIMATELY ONE YEAR AFTER COVID-19 BEGAN IN THE U.S., B) HOW ECONOMIC, SOCIAL, AND HEALTH CARE CONDITIONS HELP EXPLAIN THE ASSOCIATIONS; AND C) HOW THE ASSOCIATIONS VARY BY AGE, SEX, RACE/ETHNICITY, AND EDUCATION. AIM 2 IDENTIFIES HOW U.S. STATES’ COVID-19 POLICIES AFFECTED FATAL DRUG OVERDOSE AND SUICIDE RATES AT THE COUNTY LEVEL. USING MORTALITY DATA FROM THE NATIONAL VITAL STATISTICS SYSTEM, WE WILL ASSESS: A) THE IMMEDIATE AND LAGGED EFFECTS OF STATES’ COVID-19 POLICIES ON COUNTY-LEVEL FATAL DRUG OVERDOSE AND SUICIDE RATES AMONG ADULTS AGED 18 AND OLDER, B) HOW ECONOMIC, SOCIAL, AND HEALTH CARE CONDITIONS EXPLAIN THESE EFFECTS, AND C) VARIATION BY AGE, SEX, AND RACE/ETHNICITY. AIM 3 COLLECTS FOUR NEW ANNUAL WAVES OF THE NWS, IN CLOSE COLLABORATION WITH THE CONSORTIUM, TO IDENTIFY LONGER-TERM CONSEQUENCES OF STATES’ COVID-19 POLICIES AND INDIVIDUALS’ ADAPTATIONS ON ADULT PSYCHOLOGICAL HEALTH.

ENVIRONMENTAL TOXICANTS, RACE, AND CARDIOVASCULAR DISEASE RISK IN CHILDREN

INVESTIGATING THE ROLE OF SYSTEM XC- IN GLUTAMATE, GLUTATHIONE AND SYNAPSE HOMEOSTASIS IN VIVO

"THE SYRACUSE CENTER OF EXCELLENCE (COE) SUPPORTS A LONG-TERM VISION TO DEVELOP ""INTELLIGENT ENVIRONMENTAL QUALITY SYSTEMS"" THAT INCLUDE CAPABILITI

GENETICALLY ENCODED LIPIDATION TO MANIPULATE STRUCTURE, ASSEMBLY, AND PHASE BEHAVIOR OF PROTEINS - NEARLY ONE IN FIVE HUMAN PROTEINS ARE POST-TRANSLATIONALLY LIPIDATED, AND WHILE THE CRITICAL ROLE OF POST- TRANSLATIONAL MODIFICATION IN REGULATING DIFFERENT FACETS OF CELL BIOLOGY (E.G., SIGNALING, MEMBRANE LOCALIZATION, ETC.) HAS BEEN WELL ESTABLISHED, MANY MECHANISTIC QUESTIONS REMAIN UNANSWERED. THESE INCLUDE THE EFFECTS OF LIPIDATION ON THE ENERGETICS, CONFORMATIONS, AND FUNCTION OF LIPIDATED PROTEINS (LP) — AND ON HUMAN DISEASES. ADVANCING OUR UNDERSTANDING OF PROTEIN LIPIDATION AT THE BIOPHYSICAL LEVEL AND ELUCIDATING THE SEQUENCE– STRUCTURE–FUNCTION RULES IN VARIOUS BIOLOGICAL MILIEUS, REQUIRE STUDY OF THE CHANGES IN PROTEIN STRUCTURE AND CONFORMATION AS THE PHYSICOCHEMISTRY OF LIPID, LIPIDATION SITE, AND PROTEINS ARE SYSTEMATICALLY MODIFIED. HOWEVER, SUCH EFFORTS HAVE BEEN STYMIED BY THE CHALLENGING AND LABORIOUS METHODS TO SYNTHESIZE LIPID- MODIFIED PROTEINS. TO ADVANCE UNDERSTANDING OF PROTEIN LIPIDATION, MY PROGRAM WILL GENETICALLY ENGINEER PROKARYOTES TO INCORPORATE A DIVERSE SET OF LIPIDS INTO PROTEINS, ENABLING THE RAPID GENERATION OF COMPREHENSIVE LIBRARIES OF MODEL LPS WITH BROAD PHYSICOCHEMICAL DIVERSITY. THE OVERARCHING HYPOTHESIS OF THIS PROGRAM IS THAT THE BIOPHYSICAL CONSEQUENCES OF PROTEIN LIPIDATION IS GOVERNED BY A “MOLECULAR SYNTAX”, WHICH IS BASED ON THE INTERPLAY BETWEEN THE PHYSICOCHEMISTRY OF THE LIPID, PROTEIN, AND THE LIPIDATION SITE THAT (DE)STABILIZES FOLDING OR ASSEMBLY OF INTERMEDIATES VIA (NON)NATIVE INTERACTIONS BETWEEN LIPID, PROTEIN SIDECHAINS, AND THE AQUEOUS MILIEU. TO TEST THIS HYPOTHESIS, DIVERSE AND COMPLEMENTARY BIOPHYSICAL AND SOFT-MATTER CHARACTERIZATION TECHNIQUES WILL BE USED TO (1) STUDY THE TERTIARY STRUCTURE AND QUATERNARY ORGANIZATION OF MODEL GLOBULAR AND DISORDERED LPS ACROSS THREE DISTINCT STRUCTURAL HIERARCHIES—SINGLE PROTEIN CHAINS, LIPID-DRIVEN SUPRAMOLECULAR ASSEMBLIES, AND LIQUID-LIQUID PHASE SEPARATION-DRIVEN HIGHER-ORDER ASSEMBLIES (CONDENSATES); AND (2) QUANTIFY THE CONTRIBUTION OF THESE STRUCTURES AND THE LP’S PHYSICOCHEMISTRY TO ENCODED FUNCTIONAL/MATERIAL PROPERTIES SUCH AS BIOMOLECULAR SWITCHING, VISCOELASTICITY, AND CONTACT MECHANICS. BY ESTABLISHING PLATFORMS TO ENGINEER SEQUENCE-DEFINED LPS AND REVEALING A RIGOROUS, BIOPHYSICALLY ROOTED MOLECULAR SYNTAX UNDERLYING THEIR STRUCTURE AND ENERGETICS, THIS RESEARCH PROGRAM WILL SUBSTANTIALLY BROADEN THE DESIGN SPACE AND FUNCTIONAL LANDSCAPE OF BIOMOLECULES BEYOND PROTEIN’S AMINO ACID-BASED MOTIFS. ULTIMATELY, THIS PROGRAM WILL ENABLE A BETTER UNDERSTANDING OF THE ROLE OF LPS IN DIVERSE BIOLOGICAL MECHANISMS IN HEALTH AND DISEASE, AND THE DEVELOPMENT OF MATERIALS AND THERAPEUTICS WITH COMPLEX STRUCTURAL AND FUNCTIONAL PROPERTIES WHOSE CAPABILITIES RIVAL NATURAL BIOSYSTEMS FOR WIDE APPLICATIONS IN NANOMEDICINE AND BIOTECHNOLOGY.

THE RELATIONSHIP BETWEEN RAB11-ENDOSOMES AND THE CENTROSOME DURING DIVISION

STUDENT SUPPORT SERVICES PROGRAM

TRACING THE HEALTH CONSEQUENCES OF FAMILY SUPPORT DURING THE COVID-19 PANDEMIC - PROJECT SUMMARY THE INITIAL HEALTH IMPACTS OF THE COVID-19 PANDEMIC HAVE BEEN UNEQUAL ACROSS SOCIAL GROUPS, AND DISPARITIES IN THE ECONOMIC IMPACT OF COVID-19 HAVE AMPLIFIED EXISTING ECONOMIC INEQUALITIES AND HEALTH GAPS. WHEN FACED WITH HEALTH AND ECONOMIC CHALLENGES, AMERICANS OFTEN RELY ON FAMILY MEMBERS, INCLUDING THOSE WHO ARE NOT CORESIDENT, TO PROVIDE TIME HELP, FINANCIAL ASSISTANCE, AND SHARED HOUSING. YET, FOR MANY DISADVANTAGED AMERICANS, THE INCREASED NEED FOR HELP FROM FAMILY COMES AT A TIME WHEN THE ABILITY OF FAMILY TO PROVIDE HELP IS DIMINISHED. PUBLIC TRANSFERS DESIGNED TO ALLEVIATE ECONOMIC HARDSHIPS OF THE PANDEMIC MAY INTERACT WITH FAMILY TRANSFERS, BUT THE COMBINED EFFECTS ARE UNKNOWN. DESPITE THE INTERDEPENDENCE OF HEALTH AND ECONOMIC CHALLENGES ACROSS GENERATIONS AND THE EFFECT OF FAMILY SUPPORT ON HEALTH OUTCOMES IN THE FACE OF CHALLENGES, MOST RESEARCH ON PANDEMIC EFFECTS FOCUSES ON INDIVIDUALS AND HOUSEHOLDS. THIS PROJECT FILLS THIS GAP IN THE RESEARCH CREATING A MULTIDIMENSIONAL CONTEXTUAL DATABASE LINKED TO THE HEALTH AND RETIREMENT STUDY (HRS) AND THE PANEL STUDY OF INCOME DYNAMICS (PSID) TO EXAMINE THE EFFECTS OF THE PANDEMIC ACROSS GENERATIONS OF AMERICAN FAMILIES. THE HRS AND PSID HAVE COLLECTED DATA ON THE HEALTH AND WELL-BEING OF INDIVIDUALS AND THEIR FAMILY MEMBERS FOR DECADES, INCLUDE SUPPLEMENTS ON COVID-19 HEALTH AND ECONOMIC CHALLENGES AND ON PUBLIC AND PRIVATE TRANSFERS TO COMBAT THESE CHALLENGES, AND WILL CONTINUE INDEFINITELY TO SUPPORT AN UNDERSTANDING OF THE HEALTH IMPACTS DURING AND IN THE YEARS FOLLOWING THE PANDEMIC. THIS PROJECT ENHANCES THESE DATA BY BUILDING A CONTEXTUAL DATABASE ON THE PANDEMIC LINKABLE TO THE GENERATIONS OF FAMILIES IN THE HRS AND PSID ACROSS DIMENSIONS OF EXPOSURE TO RISK; STATE, LOCAL, AND SCHOOL POLICIES; LOCAL ECONOMIC CONDITIONS; HEALTH CARE AVAILABILITY; PREEXISTING HEALTH FACTORS; AND STRUCTURAL INEQUALITIES. THE PROPOSED PROJECT ADDRESSES FOUR AIMS: (1) BUILD AND MAINTAIN A MULTIDIMENSIONAL CONTEXTUAL DATABASE LINKED TO GENERATIONS OF HRS AND PSID FAMILIES; (2) DESCRIBE HOW PANDEMIC-RELATED HEALTH AND ECONOMIC CHALLENGES DIFFERED ACROSS GROUPS AND WERE SHARED WITHIN FAMILIES; (3) ASSESS HOW CARE, FINANCIAL SUPPORT, AND CORESIDENCE FROM FAMILY MEMBERS RESPONDED TO PANDEMIC- RELATED HEALTH AND ECONOMIC CHALLENGES AND HOW EACH INTERACTED WITH PUBLIC TRANSFER PROGRAMS; AND (4) STUDY THE PHYSICAL AND MENTAL HEALTH EFFECTS IN THE IMMEDIATE AFTERMATH AND THE YEARS FOLLOWING THE PANDEMIC AND WHETHER FAMILY SUPPORT AND PUBLIC TRANSFERS MITIGATED NEGATIVE HEALTH EFFECTS. DISPARITIES ACROSS RACE-ETHNICITY, SOCIOECONOMIC STATUS, GENDER, AGE AND RETIREMENT STATUS, AND FAMILY STRUCTURE ARE ASSESSED IN EACH AIM. CAUSAL EFFECTS OF THE IMPACT OF THE PANDEMIC WILL BE ESTIMATED USING A COMBINATION OF SUBJECTIVE ASSESSMENTS ELICITED FROM RESPONDENTS AND ANALYTIC STRATEGIES. THE RESULTS PROVIDE A COMPREHENSIVE UNDERSTANDING OF THE HEALTH AND ECONOMIC CHALLENGES THE PANDEMIC POSED TO AMERICAN FAMILIES AND HOW IT IMPACTED THEIR PHYSICAL AND MENTAL HEALTH. CONSORTIUM COLLABORATIONS WILL FACILITATE HARMONIZATION OF CONTEXTUAL FACTORS AND HEALTH OUTCOMES AND SUPPORT DISSEMINATION OF THE CONTEXTUAL DATA RESOURCE TO THE BROADER RESEARCH COMMUNITY.

EDUCATIONAL ATTAINMENT, GEOGRAPHY, AND U.S. ADULT MORTALITY RISK

MECHANISM OF CENTROSOME MATURATION IN VERTEBRATES - PROJECT SUMMARY/ABSTRACT FAITHFULLY SEGREGATING CHROMOSOMES DURING MITOSIS RELIES ON A PROPERLY ASSEMBLED SPINDLE APPARATUS WITH CENTROSOMES ANCHORING MITOTIC MICROTUBULES ON BOTH SIDES OF IT. THE CENTROSOME IS A MAJOR MICROTUBULE- ORGANIZING CENTER (MTOC) IN ANIMAL CELLS. IT CONSISTS OF A PAIR OF CENTRIOLES SURROUNDED BY THE PERICENTRIOLAR MATERIAL (PCM). THE PCM NUCLEATES AND ANCHORS MICROTUBULES AND THUS DICTATES THE MTOC ACTIVITY OF THE CENTROSOME. CENTROSOMES RAPIDLY EXPAND THEIR PCM AT THE ONSET OF MITOSIS. THIS PROCESS, TERMED CENTROSOME MATURATION, IS CRITICAL FOR SPINDLE ORGANIZATION AND CHROMOSOME SEGREGATION. HOWEVER, THERE IS A FUNDAMENTAL GAP IN UNDERSTANDING HOW THE PCM IS ASSEMBLED AND REGULATED AT THE ONSET OF MITOSIS. IN ADDITION, WHILE THE FRAMEWORK OF CENTROSOME MATURATION HAS BEEN ELUCIDATED AT THE MOLECULAR LEVEL, THE FUNDAMENTAL PRINCIPLE OF PCM ASSEMBLY REMAINS ELUSIVE AT THE ORGANELLAR LEVEL—WITHOUT AN ENCLOSING MEMBRANE, WHAT KEEPS THE CROWDED PCM PROTEINS FROM DISPERSING? WHAT GLUE HOLDS THIS MEMBRANELESS ENSEMBLE TOGETHER AS A MICRON- SIZED CENTROSOME DURING MITOSIS? IN VERTEBRATES, CENTROSOME MATURATION IS DRIVEN IN PART BY PERICENTRIN (PCNT), A LARGE PCM PROTEIN LINKED TO HUMAN DEVELOPMENTAL DISORDERS, INCLUDING PRIMORDIAL DWARSM, MICROCEPHALY, AND DOWN SYNDROME. PCNT ACTS AS A SCAFFOLD IN THE RECRUITMENT OF OTHER PCM PROTEINS DURING CENTROSOME MATURATION. OUR RECENT WORK REVEALS THAT PCNT IS DELIVERED CO-TRANSLATIONALLY TO MITOTIC CENTROSOMES AND THIS CO-TRANSLATIONAL TARGETING OF PCNT FACILITATES CENTROSOME MATURATION. OUR LONG-TERM GOAL IS TO UNDERSTAND HOW THE CENTROSOME IS ASSEMBLED AND FUNCTIONS. THE OVERALL OBJECTIVE IS TO ELUCIDATE THE ROLE OF PCNT IN REGULATING CENTROSOME MATURATION AND PCM ASSEMBLY. BASED ON OUR RECENT WORK AND PRELIMINARY STUDIES, WE HYPOTHESIZE THAT CO-TRANSLATIONAL PROTEIN TARGETING PROMOTES PCNT PHASE SEPARATION VIA PROXIMITY- DRIVEN CONDENSATION, A PROCESS THAT FACILITATES PROPER PCM ASSEMBLY, AND THAT PLK1 REGULATES THE CO- TRANSLATIONAL TARGETING PROCESS IN ADDITION TO ITS ROLE AT THE MITOTIC CENTROSOME. WE WILL TEST OUR HYPOTHESIS IN THREE SPECIC AIMS: (1) DETERMINE THE CONTRIBUTION OF PCNT CONDENSATION IN CENTROSOME MATURATION, (2) DETERMINE THE RELATIONSHIP BETWEEN CO-TRANSLATIONAL TARGETING AND PHASE SEPARATION OF PCNT, AND (3) DETERMINE THE MOLECULAR MECHANISMS THROUGH WHICH DYNEIN AND PLK1 REGULATE CO-TRANSLATIONAL TARGETING OF PCNT. THE MOLECULAR MECHANISMS UNDERLYING CENTROSOME ASSEMBLY IN VERTEBRATE CELLS REMAIN TO BE ELUCIDATED. UNDERSTANDING THESE PROCESSES IS THE KEY TO FULLY UNDERSTANDING HOW CENTROSOME FUNCTION IS NORMALLY REGULATED AND DISRUPTED IN HUMAN DISEASE.

STUDENT SUPPORT SERVICES PROGRAM

QUALITATIVE DATA REPOSITORY 2018-2021

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

JAVITS GIFTED AND TALENTED STUDENTS EDUCATION GRANT PROGRAM - JAVITS GIFTED AND TALENTED STUDENTS EDUCATION ACT

BEHAVIORAL HEALTH WORKFORCE EDUCATION AND TRAINING PROGRAM- AMERICAN RESCUE PLAN

RESTORATION OF HOMEOSTASIS OF DOWNSTREAM TARGETS OF MECP2 AS A POTENTIAL THERAPEUTIC AVENUE FOR RETT SYNDROME

THE GENOMIC BASIS AND MOLECULAR MECHANISMS OF SPECIATION - PROJECT SUMMARY ONE OF THE FUNDAMENTAL PROBLEMS IN EVOLUTIONARY BIOLOGY IS TO UNDERSTAND THE MOLECULAR GENETIC BASIS OF SPECIATION. RECENT ADVANCES IN SPECIATION RESEARCH HAVE IMPROVED OUR UNDERSTANDING OF INTERSPECIC DIVERGENCE, BUT WE STILL LACK A COMPREHENSIVE UNDERSTANDING OF THE MOLECULAR PROCESSES THAT DIVERGE AMONG INCIPIENT SPECIES. IN THE HANDFUL OF CASES WHERE THE GENETIC MECHANISMS OF REPRODUCTIVE ISOLATION HAVE BEEN ELUCIDATED, THESE INVARIABLY TACKLE LATE-EVOLVING AND/OR HYBRID DYSFUNCTION. THIS MEANS THAT WE STILL LACK A GENERAL UNDERSTANDING OF THE MOLECULAR PROCESSES THAT GOVERN PRE-ZYGOTIC REPRODUCTIVE BARRIERS, EVEN THOUGH THESE ARE OFTEN IMPORTANT EARLY IN THE SPECIATION PROCESS. MY LAB WILL TACKLE THIS PROBLEM BY IDENTIFYING THE MOLECULAR GENETIC BASIS OF PRE-ZYGOTIC AND POST-ZYGOTIC RE- PRODUCTIVE ISOLATION BETWEEN MEMBERS OF THE DROSOPHILA VIRILIS SPECIES SUB-GROUP. THIS SPECIES GROUP PROVIDES AN ESPECIALLY UNIQUE OPPORTUNITY TO DISSECT THE GENETIC AND MOLECULAR MECHANISMS OF PRE-ZYGOTIC BARRIERS, AS MEMBERS OF THIS GROUP ARE PRONE TO EVOLVE THESE TYPES OF BARRIERS QUICKLY BETWEEN SPECIES AND EVEN AMONG POPULATIONS OF THE SAME SPECIES. OUR OVERALL APPROACH INTEGRATES SEVERAL STRATEGIES TO ANSWER THE FOLLOWING QUESTIONS: WHAT ARE THE GENETIC MECHANISMS THAT CAUSE REPRODUCTIVE ISOLATION BETWEEN SPECIES? WHICH MOLEC- ULAR AND CELLULAR PROCESSES ARE AFFECTED BY DIVERGENCE OF THESE GENETIC MECHANISMS? WHAT ARE THE EVOLUTIONARY FORCES THAT DRIVE DIVERGENCE OF THE RELEVANT GENES BETWEEN SPECIES? WHAT IS THE LANDSCAPE OF NATURAL GENETIC VARIATION WITHIN AND BETWEEN SPECIES THAT FACILITATES EVOLUTIONARY DIVERGENCE OF THESE GENES? THE RST PROJECT WITHIN THIS PROPOSAL WILL FOCUS ON POST-MATING PRE-ZYGOTIC BARRIERS (I.E., GAMETIC INCOMPATIBIL- ITIES). I HAVE PREVIOUSLY SHOWN THAT GAMETIC INCOMPATIBILITIES ARE RAMPANT IN THE D. VIRILIS SUB-GROUP, AND THAT THE GENETIC BASIS IS MODERATELY COMPLEX BUT HIGHLY TRACTABLE USING A COMBINATION OF MOLECULAR GENETICS TECHNIQUES COUPLED WITH TRANSCRIPTOMIC AND PROTEOMIC ANALYSES OF REPRODUCTIVE TRAITS. THE SECOND PROJECT WILL TACKLE THE MECHANISMS OF HYBRID MALE STERILITY THAT ARE CAUSED BY INCOMPATIBILITIES BETWEEN THE Y AND X CHROMOSOMES. THE DROSOPHILA Y CHROMOSOME CARRIES SEVERAL MALE FERTILITY FACTORS, BUT IT HAS SELDOM BEEN DIRECTLY IMPLICATED IN INTERSPECIC HYBRID STERILITY BETWEEN CLOSELY RELATED SPECIES. OUR PRELIMINARY DATA SHOW THAT THE Y CHROMOSOME IS NECESSARY AND SUFCIENT TO CAUSE STERILITY IN HYBRIDS. THE RESEARCH IN THIS PROPOSAL WILL BE INNOVATIVE BECAUSE WE WILL DEPLOY CUTTING EDGE TOOLS IN CREATIVE WAYS THAT WILL ALLOW US TO DISSECT COMPLEX GENETIC MECHANISMS IN A NEWLY ESTABLISHED MODEL SYSTEM.

SPECIFICATION OF FUNCTIONAL CHARACTERISTICS OF SPINAL CORD INTERNEURONS

ACCEPTANCE AND COMMITMENT THERAPY FOR HIV+ HAZARDOUS DRINKERS: A RANDOMIZED CLINICAL TRIAL - PROJECT SUMMARY/ABSTRACT ALCOHOL CONSUMPTION AT HAZARDOUS LEVELS IS ASSOCIATED WITH NEGATIVE CONSEQUENCES AT NEARLY EVERY STEP OF THE HIV CARE CONTINUUM. IT IS A CRITICAL FACTOR IN HIV TREATMENT THAT SIGNIFICANTLY CONTRIBUTES TO POOR TREATMENT-RELATED OUTCOMES. RANDOMIZED CLINICAL TRIALS (RCTS) OF ALCOHOL INTERVENTIONS FOR PEOPLE WITH HIV (PWH) HAVE HAD LIMITED SUCCESS, PERHAPS DUE TO AN INCREASINGLY RECOGNIZED SYNDEMIC OF CO-OCCURRING HAZARDOUS ALCOHOL USE AND OTHER MENTAL HEALTH-RELATED PROBLEMS AMONG PWH. UP TO 63% OF PWH MEET CRITERIA FOR BOTH A SUBSTANCE USE DISORDER AND ANOTHER PSYCHIATRIC DISORDER—NECESSITATING A SHIFT IN THE LITERATURE TOWARDS TRANSDIAGNOSTIC APPROACHES THAT TARGET CORE PSYCHOLOGICAL PROCESSES THAT UNDERLIE MULTIPLE MENTAL HEALTH AND SUBSTANCE- RELATED PROBLEMS. ONE TRANSDIAGNOSTIC MECHANISM THAT IS PARTICULARLY RELEVANT TO ALCOHOL AND OTHER SUBSTANCE USE IS EXPERIENTIAL AVOIDANCE (EA)— I.E., REPEATED, AND MALADAPTIVE, USE OF SUBSTANCES AND/OR OTHER BEHAVIORS TO ESCAPE OR AVOID UNWANTED THOUGHTS, FEELINGS, AND/OR URGES. ACCEPTANCE AND COMMITMENT THERAPY (ACT) IS A PROMISING TRANSDIAGNOSTIC INTERVENTION FOR PWH THAT TARGETS EA. ACT IS AN EMPIRICALLY SUPPORTED TREATMENT FOR MULTIPLE PSYCHOLOGICAL AND BEHAVIORAL HEALTH-RELATED OUTCOMES; HOWEVER THERE HAVE NOT BEEN ANY FULL-SCALE RCTS OF ACT FOR ALCOHOL USE AMONG ANY POPULATION, INCLUDING PWH. WE RECENTLY ADAPTED A TELEPHONE- DELIVERED ACT INTERVENTION ORIGINALLY DEVELOPED FOR SMOKING CESSATION, INTO AN INTERVENTION FOR PWH WHO DRINK AT HAZARDOUS LEVELS (NIH/NIAAA; R34AA026246). WITH A MULTIDISCIPLINARY TEAM, AND WITH TWO ROUNDS OF INPUT FROM PWH, WE DEVELOPED A SIX-SESSION, TELEPHONE-DELIVERED ACT INTERVENTION FOR ALCOHOL USE AND SUBSEQUENTLY CONDUCTED A PILOT FEASIBILITY/ACCEPTABILITY RCT. WE FOUND HIGH ACCEPTABILITY OF THE ADAPTED ACT INTERVENTION, AND EVIDENCE OF FEASIBILITY FOR CONDUCTING A FULL-SCALE, REMOTE, RCT. THE OVERALL OBJECTIVE OF THIS APPLICATION IS THEREFORE TO DETERMINE THE RELATIVE EFFICACY OF ACT, COMPARED TO A STANDARD BRIEF ALCOHOL INTERVENTION (BI), FOR REDUCING ALCOHOL USE AND COMORBID SYMPTOMS OF DEPRESSION, ANXIETY, AND STRESS AMONG ADULT PWH WHO ARE HAZARDOUS DRINKERS. THE SPECIFIC AIMS ARE: TO DETERMINE THE RELATIVE EFFICACY OF ACT, COMPARED TO BI, FOR REDUCING ALCOHOL USE AMONG PWH (AIM 1) AND TO DETERMINE IF ACT HAS AN EFFECT ON TRANSDIAGNOSTIC PROCESSES THAT IN TURN AFFECT ALCOHOL USE AND OTHER PSYCHOLOGICAL AND FUNCTIONAL OUTCOMES (AIM 2). WE WILL ACCOMPLISH THESE AIMS BY: CONDUCTING A FULLY REMOTE, RELATIVE EFFICACY RCT IN WHICH WE RANDOMLY ASSIGN 300 PWH WHO ARE HAZARDOUS DRINKERS TO EITHER THE ACT INTERVENTION WE DEVELOPED (N = 150), OR A BI INTERVENTION (N = 150) PREVIOUSLY SHOWN TO REDUCE ALCOHOL USE AMONG PWH. WE WILL ASSESS ALCOHOL-RELATED OUTCOMES—VIA SELF-REPORT AND A BIOMARKER (PHOSPHATIDYLETHANOL) – AT BASELINE, POST-TREATMENT, AND AGAIN 3-, 6-, AND 12-MONTHS POST-RANDOMIZATION. WE WILL ALSO MEASURE EA TO DETERMINE IF IT MEDIATES TREATMENT EFFECTS FOR ALCOHOL USE AND OTHER PSYCHOLOGICAL (I.E., SYMPTOMS OF DEPRESSION, ANXIETY, AND STRESS) AND FUNCTIONAL OUTCOMES, MEASURED AT ALL TIMEPOINTS.

DEVELOPMENT OF A FEDERAL CYBERFORCE AT SYRACUSE UNIVERSITY: 2010-2014 SCHOLARSHIP PROGRAM

THE ROLE AND MECHANISMS OF UBQLN2-MEDIATED PHASE TRANSITIONS IN THE ASSEMBLY AND DISASSEMBLY OF BIOMOLECULAR CONDENSATES

FY 17 BOOTS TO BUSINESS

CHARACTERIZATION OF ENDOCRINE SIGNALING AND RNAI PATHWAYS AS MECHANISMS REGULATING ENVIRONMENTAL PROGRAMMING IN C. ELEGANS

RACIAL DIFFERENCES IN DEVELOPMENTAL AND DAILY SLEEP-ALCOHOL ASSOCIATIONS IN YOUTH

QUALITATIVE DATA REPOSITORY 2021-2024

CONTROLLING CATHETER-ASSOCIATED URINARY TRACT INFECTIONS USING SMART CATHETERS WITH RATIONALLY DESIGNED ACTIVE TOPOGRAPHIES - CATHETER ASSOCIATED URINARY TRACT INFECTION (CAUTI) IS ONE OF THE MOST COMMON HEALTHCARE-ASSOCIATED INFECTIONS (HAIS), WITH A PREVALENCE OF 13 – 15% IN THE UNITED STATES. CAUTIS ARE ALSO BLAMED FOR INCREASED MORBIDITY AND MORTALITY OF AFFECTED PATIENTS WITH AN ESTIMATED 13,000 DEATHS ANNUALLY. IT IS WELL KNOWN THAT THE ABIOTIC CATHETER MATERIALS ARE PRONE TO COLONIZATION OF MICROBES, WHICH THEN ASCEND THE CATHETER VIA MOTILITY AND BIOFILM FORMATION, CAUSING INFECTIONS IN THE URINARY TRACT. DUE TO THE PROTECTION OF THE BIOFILM MATRIX AND SLOW GROWTH OF ATTACHED CELLS, BIOFILM CELLS ARE UP TO 1,000 TIMES MORE RESISTANT TO ANTIMICROBIALS THAN THE PLANKTONIC CELLS OF THE SAME SPECIES. THUS, CAUTIS ARE DIFFICULT TO TREAT AND BLOCKAGE OF THE CATHETER LUMEN CAN OCCUR ESPECIALLY DURING LONG-TERM USE, LEADING TO STONE FORMATION AND INFECTIONS OF THE BLADDER AND EVEN KIDNEY. TREATMENT OF CAUTIS WITH HIGH DOSES OF ANTIMICROBIAL AGENTS CAN ALSO ADVERSELY PROMOTE THE DEVELOPMENT OF MULTIDRUG RESISTANT BACTERIA. DESPITE EXTENSIVE RESEARCH TO DATE, NO CURRENT TECHNOLOGY CAN PROVIDE LONG-TERM (>30 DAYS) FOULING CONTROL. THIS UNMET CHALLENGE MOTIVATED US TO ENGINEER SMART CATHETERS TO ULTIMATELY ERADICATE CAUTI. RECENTLY, THE PI’S LAB DEVELOPED A NEW ANTIFOULING STRATEGY BASED ON ACTIVE TOPOGRAPHY THAT DRIVES MAGNETICALLY RESPONSIVE MICRON-SIZE PILLARS TO BEAT WITH A TUNABLE FREQUENCY AND FORCE LEVEL. THIS WAS ACHIEVED BY LOADING FE3O4 NANOPARTICLES ON THE TIP OF EACH PILLAR AND GENERATING AN ELECTROMAGNETIC FIELD USING AN INSULATED COPPER COIL EMBEDDED IN THE CATHETER WALL (THUS DOES NOT CHANGE THE CATHETER PROFILE). THIS NOVEL DESIGN DEMONSTRATED UNPRECEDENTED STRONG ANTIFOULING ACTIVITIES THAT CAN INHIBIT BIOFILM FORMATION OF MULTIPLE SPECIES BY UP TO 3.6 LOGS (99.98%) FOR 48 HOURS AND REMOVE MATURE BIOFILMS BY UP TO 3.5 LOGS (99.97%) ON DEMAND WITH A STRONGER FORCE, COMPARED TO THE FLAT CONTROL. A PROTOTYPE CATHETER WITH MICRON-SIZE PILLARS ON THE INNER WALL WAS ENGINEERED AND REMAINED CLEAN FOR MORE THAN 30 DAYS UNDER THE FLOW OF ARTIFICIAL URINE AND THE CHALLENGE OF UROPATHOGENIC ESCHERICHIA COLI (UPEC), WHILE BOTH FLAT AND STATIC CONTROLS WERE COMPLETELY BLOCKED BY UPEC BIOFILMS WITHIN 5 DAYS. THESE RESULTS MOTIVATED THE TEAM TO FURTHER DEVELOP THIS TECHNOLOGY TO ALSO CONTROL BIOFOULING OF THE OUTER CATHETER WALL, WHICH IS COVERED BY URETHRAL MUCOSA AND INVOLVED IN TWO THIRDS OF CAUTIS. INTEGRATED SIMULATION AND EXPERIMENTAL STUDIES WILL BE CONDUCTED TO UNDERSTAND THE MECHANISM OF BIOFOULING CONTROL BY ACTIVE TOPOGRAPHY AND THE DESIGN PRINCIPLES FOR ANTIFOULING TOPOGRAPHIES ON BOTH SIDES OF THE CATHETER WALL. THE BEST DESIGN WILL BE FURTHER TESTED IN VIVO USING A RABBIT MODEL OF CAUTI INDUCED BY UPEC. BOTH CAUTI PREVENTION (UP TO 30 DAYS) AND REMOVAL OF ESTABLISHED BIOFILMS WILL BE EVALUATED.

INVESTIGATING THE MEANINGFULNESS OF PRESERVICE PROGRAMS ACROSS THE CONTINUUM OF TEACHING (IMPPACT) IN SCIENCE EDUCATION

HOMELESS VETERANS (HVRP)

PRE-FRONTAL TDCS AS A NOVEL INTERVENTION TO REDUCE EFFECTS OF POST-STROKE FATIGUE WHILE IMPROVING LANGUAGE AND ATTENTION IN APHASIA - PROJECT SUMMARY FATIGUE IS HIGHLY PREVALENT IN THE STROKE POPULATION, AND IT IS OFTEN REPORTED AS ONE OF THE MOST DEBILITATING POST- STROKE SYMPTOMS. UNFORTUNATELY, POST-STROKE FATIGUE IS NOT EFFECTIVELY MANAGED, PRIMARILY BECAUSE LITTLE EVIDENCE EXISTS SUPPORTING POST-STROKE FATIGUE TREATMENT. TRANSCRANIAL DIRECT CURRENT STIMULATION (TDCS) IS A TYPE OF NEUROMODULATION THAT HAS BEEN SHOWN TO IMPROVE TREATMENT RESPONSE IN PERSONS WITH APHASIA (PWA) AND IS A PROMISING TREATMENT APPROACH FOR REDUCING POST-STROKE FATIGUE. CONSIDERING THE POTENTIAL IMPACT OF FATIGUE ON APHASIA RECOVERY, THERE IS AN URGENT AND CRITICAL NEED TO ASSESS INTERVENTIONS THAT CAN ALLEVIATE THE CONSEQUENCES OF POST-STROKE FATIGUE, BOOST COGNITION AND LANGUAGE, AND MAXIMIZE THE BRAIN’S NEUROPLASTICITY. STUDIES HAVE SHOWN THAT TDCS APPLIED TO DORSOLATERAL PREFRONTAL CORTEX (DLPFC) CAN IMPROVE ATTENTION AND LANGUAGE COMPREHENSION AFTER STROKE. HOWEVER, IT REMAINS UNKNOWN IF TDCS ADMINISTERED TO DLPFC CAN SIMULTANEOUSLY ENHANCE ATTENTION TASK PERFORMANCE, IMPROVE LANGUAGE COMPREHENSION, AND REDUCE POST-STROKE FATIGUE. THE LONG-TERM GOAL OF THIS RESEARCH IS TO INCREASE THE EFFECTIVENESS OF SPEECH AND LANGUAGE TREATMENTS FOR APHASIA BY ACCOUNTING FOR INDIVIDUAL AND COGNITIVE FACTORS THAT COULD NEGATIVELY AFFECT RECOVERY. THIS PROJECT WILL ADVANCE THE NIDCD’S MISSION BY DIRECTLY ADDRESSING ONE OF THESE FACTORS TO IMPROVE STROKE AND APHASIA REHABILITATION. THE PROPOSED PROJECT IS A CRITICAL STEP TOWARDS ADVANCING THE CLINICAL SCIENCE OF APHASIA TREATMENT THROUGH TWO SPECIFIC AIMS: 1) TO CONDUCT A RIGOROUS CLINICAL TRIAL IMPLEMENTING NEUROMODULATION IN COMBINATION WITH BEHAVIORAL ATTENTION-FOCUSED LANGUAGE TREATMENT TO IMPROVE ATTENTION, LANGUAGE, AND FATIGUE OUTCOMES FOR PWA, AND 2) TO COMPREHENSIVELY IDENTIFY MECHANISTIC INTERRELATIONSHIPS AMONG POST-STROKE FATIGUE, COGNITIVE DEFICITS, AND LANGUAGE DEFICITS IN PWA. USING A 2X2 FACTORIAL DESIGN, PARTICIPANTS WILL FIRST BE RANDOMIZED TO TDCS CONDITION (ACTIVE OR SHAM) AND THEN RANDOMIZED TO A BEHAVIORAL SENTENCE COMPREHENSION CONDITION (+ATTENTION OR - ATTENTION). PARTICIPANTS WILL UNDERGO 10 SESSIONS OF TREATMENT AND OUTCOME MEASURES WILL BE ADMINISTERED AT 3 TIME POINTS (BASELINE, POST-TRAINING, 3-MONTH FOLLOW-UP). ATTENTION PERFORMANCE WILL BE MEASURED USING SUSTAINED, ALERTING, ORIENTING, AND EXECUTIVE ATTENTION TASKS. SENTENCE COMPREHENSION WILL BE MEASURED USING A TREATMENT- BASED AND A FUNCTIONAL SENTENCE COMPREHENSION TASK. FATIGUE WILL BE MEASURED USING AN APHASIA-ADAPTED VERSION OF THE FATIGUE SEVERITY SCALE, A COMMONLY USED FATIGUE MEASUREMENT TOOL. WE WILL ADDRESS OUR STUDY AIMS BY COMPARING PERFORMANCE ON THESE TASKS ACROSS ALL COMBINATIONS OF TREATMENT (+/- TDCS; +/- ATTENTION- FOCUSED LANGUAGE TREATMENT). AT THE CONCLUSION OF THIS CLINICAL TRIAL, WE EXPECT TO PROVIDE EVIDENCE THAT ACTIVE ANODAL TDCS TO DLPFC IN COMBINATION WITH BEHAVIORAL ATTENTION-FOCUSED LANGUAGE TREATMENT CAN ENHANCE ATTENTION ABILITY, IMPROVE SENTENCE COMPREHENSION, AND REDUCE POST-STROKE FATIGUE. WE ALSO EXPECT TO SHOW THAT LANGUAGE AND ATTENTION DEFICITS ARE ASSOCIATED WITH CLINICALLY SIGNIFICANT FATIGUE AND THAT CLINICALLY SIGNIFICANT FATIGUE IS ASSOCIATED WITH POORER TREATMENT OUTCOMES.

DE-EE0002121 -- ENVIRONMENTAL SYSTEM CENTER AT SYRACUSE UNIVERSITY

GEOGRAPHIC TRENDS AND DISPARITIES IN PSYCHOSOCIAL WELLBEING, HEALTH BEHAVIORS, AND MORTALITY IN MIDLIFE - THE RISE IN U.S. MIDLIFE MORTALITY IN RECENT DECADES HAS BEEN SUBSTANTIAL, ENDING THE INCREASE IN LIFE EXPECTANCY AROUND 2010 AND TRIGGERING ITS DECLINE AFTER 2014. THE TREND HAS BEEN EXACERBATED BY THE COVID-19 PANDEMIC. ONE OF THE MOST TELLING FEATURES OF THE RISE IS ITS GEOGRAPHIC PATTERN. IT HAS BEEN PRONOUNCED IN MIDWESTERN AND SOUTHERN STATES AND IN RURAL AREAS AND SMALL CITIES. EXPLAINING THESE GROWING GEOGRAPHIC DISPARITIES IS A NECESSARY STEP TOWARD IDENTIFYING THE ETIOLOGIES OF RISING MIDLIFE MORTALITY OVERALL. THE OVERARCHING OBJECTIVE OF THIS PROJECT IS TO ASSESS HOW STATE POLICY CONTEXTS AND COUNTY ECONOMIC CONTEXTS COLLECTIVELY PREDICT GROWING GEOGRAPHIC DISPARITIES IN 1) ALL-CAUSE MIDLIFE MORTALITY, 2) MAJOR TREND-DRIVING CAUSES OF DEATH FOR MIDLIFE MORTALITY: SUICIDE, DRUG OVERDOSE, ALCOHOL-INDUCED CAUSES, AND CARDIOMETABOLIC DISEASES, AND 3) PSYCHOSOCIAL AND HEALTH BEHAVIOR RISK FACTORS FOR THOSE CAUSES OF DEATH THE PROJECT ANSWERS KEY UNRESOLVED QUESTIONS ABOUT THE GROWING GEOGRAPHIC DISPARITIES IN MIDLIFE MORTALITY THAT HAVE BEEN MAJOR OBSTACLES TO UNDERSTANDING THEM. ONE QUESTION REGARDS THE COLLECTIVE INFLUENCE OF STATE AND LOCAL CONTEXTS. STUDIES TEND TO FOCUS ON STATE OR LOCAL CONTEXTS, PROVIDING AN INCOMPLETE EXPLANATION. WE ADVANCE THIS WORK BY EXAMINING STATE AND LOCAL CONTEXTS CONCOMITANTLY, WHICH IS CRITICAL BECAUSE THEY MAY AFFECT MORTALITY VIA INDEPENDENT AND SYNERGISTIC PROCESSES. A SECOND QUESTION CONCERNS THE INFLUENCE OF STATES’ POLICY “CONTEXTS”. STATES HAVE ENACTED HIGHLY CORRELATED, OR “BUNDLED”, POLICIES WHICH NECESSITATES NEW APPROACHES FOR UNDERSTANDING THEIR INFLUENCE ON MORTALITY. WE ADVANCE THIS WORK BY USING INNOVATIVE METHODS TO DEVELOP ANNUAL SCORES FOR INTERPRETABLE POLICY BUNDLES. A THIRD QUESTION CONCERNS THE DEGREE TO WHICH STATE AND LOCAL CONTEXTS COLLECTIVELY PREDICT INDIVIDUAL-LEVEL PSYCHOSOCIAL WELLBEING AND HEALTH BEHAVIORS—I.E., THE PROXIMATE DETERMINANTS OF THE FOUR MAJOR CAUSES OF DEATH BEHIND RISING MIDLIFE MORTALITY. DEINDUSTRIALIZATION, DECLINES IN GOOD JOBS, AND CONCOMITANT DISRUPTIONS TO FAMILIES AND COMMUNITIES IN SOME PLACES MAY HAVE HARMED THE PSYCHOSOCIAL WELLBEING OF MIDLIFE ADULTS, PARTICULARLY THOSE WITHOUT A 4-YEAR COLLEGE DEGREE, LEADING TO CONSUMPTION OF DRUGS, ALCOHOL, AND UNHEALTHY FOOD. WE ADVANCE THIS WORK BY EXAMINING HOW STATE AND LOCAL CONTEXTS COLLECTIVELY PREDICT PSYCHOSOCIAL AND HEALTH BEHAVIOR RISK FACTORS FOR THE FOUR MAJOR CAUSES OF DEATH. THE PROJECT WILL ACCOMPLISH ITS OBJECTIVE THROUGH THREE SPECIFIC AIMS. AIM 1 IDENTIFIES HOW STATE POLICY AND COUNTY ECONOMIC CONTEXTS COLLECTIVELY PREDICT COUNTY-LEVEL MORTALITY (FROM ALL CAUSES AND THE FOUR SPECIFIC CAUSES) FROM 1990-2025 FOR ALL MIDLIFE ADULTS AND BY AGE, SEX, RACE-ETHNICITY, EDUCATION, AND METRO STATUS. AIM 2 IDENTIFIES HOW STATE POLICY AND COUNTY ECONOMIC CONTEXTS COLLECTIVELY PREDICT INDIVIDUAL-LEVEL PSYCHOSOCIAL AND HEALTH BEHAVIOR RISK FACTORS FROM 2021-2025, AND EXAMINES HYPOTHESIZED PATHWAYS, AMONG ALL MIDLIFE ADULTS AND BY AGE, SEX, RACE/ETHNICITY, EDUCATION, AND METRO STATUS. AIM 3 MERGES THE 100+ ANNUAL STATE AND COUNTY MEASURES INTO MULTIPLE GEOCODED SURVEYS AVAILABLE VIA THE UM’S VIRTUAL DATA ENCLAVE. WE WILL ALSO DISSEMINATE THE DATA, DOCUMENTATION, AND CODE VIA ICPSR AND OFFER WORKSHOPS ON THESE RESOURCES.

DEVELOPMENT OF MODULAR SYNTHETIC SENSORS FOR PROTEIN BIOMARKER DETECTION - PROJECT SUMMARY PROTEIN DETECTION AND BIOMARKER PROFILING HAVE WIDE-RANGING SIGNIFICANCE IN MANY AREAS OF DISEASE PROGNOSTICS, DIAGNOSTICS, AND THERAPEUTICS. FOR EXAMPLE, THE PROGRESSION AND DEVELOPMENT OF VARIOUS CANCERS ARE ACCOMPANIED BY ALTERATIONS IN SPECIFIC PROTEIN EXPRESSIONS. THESE VARIATIONS IN DIFFERENT BIOFLUIDS ARE INDICATIVE OF DISEASE-LIKE CONDITIONS. A LONG-STANDING DIFFICULTY OF EXISTING METHODS IS THE DETECTION OF MULTIPLE PROTEINS IN A COMPLEX BIOLOGICAL SAMPLE WITH HIGH SENSITIVITY AND A BROAD DYNAMIC RANGE. IN ADDITION, SCALABLE PROTEIN IDENTIFICATION AND QUANTIFICATION TECHNIQUES ARE USUALLY CREATED WITH SACRIFICED SENSITIVITY, SO THEIR APPLICABILITY IN CLINICAL SETTINGS REMAINS LIMITED. TO OVERCOME THESE FUNDAMENTAL AND TECHNICAL SHORTCOMINGS, WE WILL DEVELOP, OPTIMIZE, AND VALIDATE A NEXT-GENERATION CLASS OF SENSING ELEMENTS FOR TARGETED PROTEIN BIOMARKER DETECTION AT SINGLE-RECOGNITION EVENT PRECISION. THESE PROPOSED STUDIES AIM TO ENGINEER SYNTHETIC SENSORS MADE OF A SINGLE-POLYPEPTIDE CHAIN PROTEIN NANOSTRUCTURE. THIS PROTEIN NANOSTRUCTURE ENCOMPASSES A MEMBRANE PROTEIN PORE AND A PROGRAMMABLE PROTEIN BINDER. THE PROTEIN PORE IS A REPORTER THAT GENERATES AN OUTPUT SIGNATURE, WHICH DEPENDS ON THE IDENTITY AND QUANTITY OF THE BIOMARKER. A PROGRAMMABLE BINDER IS A SMALL ANTIBODY- MIMETIC SCAFFOLD, SUCH AS A MONOBODY OR AN AFFIBODY, SAMPLING THE TARGETED BIOMARKER IN SOLUTION. HENCE, A GENERIC BINDER CAN BE MODIFIED FOR MULTIPLE PROTEIN ANALYTES. THIS WAY, SUCH A MODULAR DESIGN SIGNIFICANTLY EXPANDS THE UTILITY OF THESE SENSING ELEMENTS FOR NUMEROUS BIOMARKERS WHILE PRESERVING THEIR HIGH SENSITIVITY AND SPECIFICITY USING THE RESISTIVE-PULSE TECHNIQUE. THIS CRITICAL BENEFIT IS FACILITATED BY THE GENETICALLY ENCODED NATURE OF THESE SENSORS SO THAT THEY CAN FORM COMBINATORIAL LIBRARIES OF TETHERED BINDERS. THESE MANIPULATIONS OF MODULAR PORE-BASED DETECTORS EQUIPPED WITH ANTIBODY-MIMETIC BINDERS HAVE NOT BEEN CONDUCTED PREVIOUSLY. THEY ARE INTENDED FOR USE IN CHALLENGING BIOFLUIDS, WHERE SPECIFIC BINDER-BIOMARKER INTERACTIONS WILL BE UNAMBIGUOUSLY DISTINGUISHED FROM NONSPECIFIC INTERACTIONS OF THE MEDIUM CONSTITUENTS. FURTHER ADVANTAGES OF THIS REAL-TIME AND LABEL-FREE TECHNOLOGY INCLUDE MAINTAINING AN AMPLIFIED SIGNAL-TO-NOISE RATIO IN A WIDE DYNAMIC RANGE DUE TO THE SUPERIOR BANDWIDTH OF TIME-RESOLVED ELECTRICAL RECORDINGS. THE EXPECTED IMMEDIATE OUTCOMES OF THESE PROPOSED STUDIES WILL BE THE FOLLOWING: (I) DEVELOPMENT, OPTIMIZATION, AND VALIDATION OF MONOBODY- AND AFFIBODY-BASED SENSORS FOR PROTEIN DETECTION; (II) PROTEIN BIOMARKER DETECTION IN MULTIPLEXED AND HIGH- THROUGHPUT FORMULATIONS; (III) PROTEIN BIOMARKER DETECTION IN HETEROGENEOUS SOLUTIONS. THESE RESULTS WILL REPRESENT A PLATFORM FOR FINGERPRINTING PANELS OF MULTIPLE PROTEIN TARGETS IN BIOFLUIDS WITHOUT IMPAIRING THE SENSITIVITY OF THESE DETERMINATIONS. THIS PROPOSED RESEARCH WILL IMPACT QUANTITATIVE PROTEOMICS AND BIOSENSOR TECHNOLOGY BY PROVIDING A FUNDAMENTAL BASIS AND TOOLS FOR ULTRASENSITIVE BIOMARKER DETECTION.

TRIO - STUDENT SUPPORT SERVICES - STUDENT SUPPORT SERVICES PROGRAM

CENTER FOR AGING AND POLICY STUDIES

SYRACUSE UNIVERSITY INDUSTRIAL ASSESSMENT CENTER (SU-IAC)

PERSONALIZED FEEDBACK INTERVENTION TO ADDRESS HAZARDOUS DRINKING AND ALCOHOL-OPIOID INTERACTIONS AMONG ADULTS WITH CHRONIC PAIN

FY 2018 B2B OPTION YEAR AWARD

AGONISTIC STRESS AND CVD RISK IN YOUNG ADULTS

COLLABORATIVE RESEARCH: HOW IS RIFTING EXHUMING THE YOUNGEST HIGH-PRESSURE AND ULTRAHIGH-PRESSURE (HP/UHP) ROCKS ON EARTH?

THROUGH THIS PROJECT, THE RECIPIENT WILL PROVIDE ENVIRONMENTAL FINANCE EXPERTISE AND OUTREACH TO STATES, TRIBES, LOCAL GOVERNMENTS AND THE PRIVATE SE

DISENTANGLEMENT OF THE MLL-WDR5 PROTEIN-PROTEIN RECOGNITION EVENTS

SYRACUSE UNIVERSITY RONALD E. MCNAIR POST-BACCALAUREATE ACHIEVEMENT PROGRAM

COMBINED PRIORITY FOR PERSONNEL DEVELOPMENT

COLLABORATIVE RESEARCH: UNDERSTANDING THE IMPACTS OF ICE STORMS ON FOREST ECOSYSTEMS OF THE NORTHEASTERN UNITED STATES

MRI: TRACK I: DEVELOPMENT OF ULTRAFAST HIGH GRANULARITY MODULES FOR TIMING LAYERS FOR THE LHCB UPGRADE 2 AND FUTURE COLLIDER CALORIMETER APPLICATIONS -THIS PROJECT IS FOCUSED ON DEVELOPING MODULES THAT PROVIDE PRECISE TIMING AND SPACE INFORMATION FOR THE CONSTRUCTION OF A HIGH-GRANULARITY TIMING-LAYER TO BE INTEGRATED INTO THE LHCB UPGRADE II CALORIMETER AT THE CERN LABORATORY IN SWITZERLAND AND FUTURE HIGH-LUMINOSITY COLLIDERS. THE DEVELOPMENT OF THIS INSTRUMENT WILL BE AN ESSENTIAL ELEMENT OF AN AMBITIOUS PHYSICS PROGRAM RICH IN DISCOVERY POTENTIAL THAT WILL ADVANCE OUR UNDERSTANDING OF ELEMENTARY PARTICLES AND THEIR INTERACTIONS. HIGH SPATIAL RESOLUTION COMBINED WITH A PRECISE TIME STAMP HAS BROAD APPLICATIONS TO FUTURE COLLIDERS AND INDUSTRIAL INSTRUMENTS, FOR EXAMPLE MEDICAL DEVICES. THE GROUP WILL DEVELOP FULL-SIZE MODULES COMPRISING A SENSOR AND ITS PROCESSING ELECTRONICS, INTEGRATED INTO AN OPTIMIZED PACKAGE WITH ELECTRICAL AND MECHANICAL PROPERTIES SUITABLE FOR SCALABILITY INTO LARGE PLANES. ITS COMPONENTS COMPRISE NOVEL ULTRAFAST SENSORS WITH FINE SPACE SEGMENTATION AND COMPLEX ELECTRONICS THAT COMBINE SOPHISTICATED SIGNAL MANIPULATION AND DATA PROCESSING. THIS R&D PROJECT IS SYNERGISTIC WITH THE SEMICONDUCTOR INDUSTRY IN THE UNITED STATES AND THE MANY EFFORTS OF APPLYING ARTIFICIAL INTELLIGENCE TECHNIQUES TO ADVANCED TECHNOLOGY. THE GOAL OF THE EFFORT IS TO INTEGRATE THIS DETECTOR IN THE LHCB UPGRADE II AT THE CERN LHC COLLIDER FOLLOWING THE HIGH-LUMINOSITY UPGRADE (HL-LHC). THE HL-LHC ERA OFFERS THE POSSIBILITY OF UNPRECEDENTED REACH IN MANY LANDMARK MEASUREMENTS. THE HIGH LUMINOSITY, COMBINED WITH INCREASED EFFICIENCY FOR PHOTONS, PIONS, ELECTRONS, AND POSITRONS, WILL BE A FORMIDABLE COMBINATION THAT, THANKS TO THE FLEXIBLE SOFTWARE TRIGGER, WILL ALLOW THE GROUP TO OPTIMIZE THE DATA TAKING TO SPECIFIC INTERESTING DECAYS. IN ADDITION, THIS INSTRUMENT IS ALIGNED WITH BASIC RESEARCH NEEDS IN CALORIMETRY FOR FUTURE COLLIDER APPLICATIONS. IT CAN ALSO BE ADAPTED TO CONSTRUCT HADRON IDENTIFICATION DEVICES FOR FUTURE E+E- COLLIDERS. THE STRINGENT SPECIFICATIONS INVOLVE SENSOR AND MICROELECTRONICS FEATURES THAT ARE AT THE EDGE OF CURRENT TECHNOLOGIES. CHALLENGING REQUIREMENTS ON THE SPEED AND RADIATION RESISTANCE ON THE SENSORS, SPEED AND LOW NOISE PERFORMANCE OF THE ANALOG PROCESSING, COMPLEXITY OF THE DIGITAL SECTION, AND ENCOMPASSING ALGORITHMS POSSIBLY OPTIMIZED WITH MACHINE-LEARNING TECHNIQUES HAVE FAR-REACHING IMPLICATIONS FOR ADVANCEMENT IN MICROELECTRONICS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

GENERALIZABLE NANOSENSORS FOR PROBING HIGHLY SPECIFIC INTERACTIONS OF PROTEIN KINASES - PROJECT SUMMARY DEVELOPING NOVEL TECHNOLOGIES FOR IDENTIFYING AND QUANTIFYING TRANSIENT PROTEIN-PROTEIN INTERACTIONS IS CRITICAL IN BASIC RESEARCH AND MEDICAL BIOTECHNOLOGY. PROTEIN KINASES REPRESENT A FOCAL GROUP AMONG STRATEGIC DRUG TARGETS FOR TREATING NUMEROUS HEMATOLOGICAL MALIGNANCIES AND SOLID TUMORS. YET, CREATING HIGH-RESOLUTION SENSORS TO DETECT, QUANTIFY, AND ANALYZE THE PLASTICITY OF DIVERSE KINOME MEMBERS IN A BROAD DYNAMIC RANGE OF INTERACTIONS REMAINS DIFFICULT. THIS CHALLENGE IS EXACERBATED BECAUSE THE KINASE SUPERFAMILY MEMBERS VARY DRASTICALLY IN THEIR COMPLEXITY. TO ADDRESS THIS LONG-STANDING TECHNOLOGICAL SHORTCOMING, WE WILL FORMULATE, DEVELOP, AND VALIDATE A NEW CLASS OF GENERALIZABLE AND HIGHLY SPECIFIC NANOPORE SENSORS (NANOSENSORS) FOR KINASE ANALYTICS. THE KEY INNOVATING ASPECT OF THIS DESIGN IS FUSING A GENERIC PROTEIN RECOGNITION LIGAND WITH A TRANSMEMBRANE PROTEIN NANOPORE. THIS APPROACH WILL EMPLOY A ROBUST NANOSTRUCTURE MADE OF A SINGLE POLYPEPTIDE ENTITY WITH NO REQUIREMENT FOR AN ADDITIONAL TAIL OR OTHER EXOGENOUS TAGS. THE BINDING INTERFACE OF THE PROTEIN RECOGNITION LIGAND IS INTERCHANGEABLE TO ACCOMMODATE THE REQUIRED SPECIFICITY FOR A TARGETED KINASE, WHEREAS THE NANOPORE FACILITATES THE GENERATION OF A REPORTING ELECTRICAL SIGNAL. A PROTEIN KINASE ANALYTE IN SOLUTION PRODUCES A UNIQUE ELECTRICAL SIGNATURE THAT VARIES WITH ITS IDENTITY AND QUANTITY. THE REPORTING SIGNAL IS MEDIATED BY THE LIGAND-KINASE ASSEMBLY AT THE NANOPORE TIP. IN THESE STUDIES, KINASE RECOGNITION EVENTS WILL BE DISCRIMINATED AT SINGLE-MOLECULE PRECISION WITHOUT THE NECESSITY OF USING COMPLEX DATA ANALYSIS ALGORITHMS. THIS ENGINEERING STRATEGY SUBSTANTIALLY BROADENS THE SPECTRUM OF APPLICATIONS OF THESE NANOSENSORS TO VARIOUS KINASES AND THEIR INTERACTIONS. OUR PRELIMINARY STUDIES PROVE THE POWER OF THIS APPROACH BY CREATING A SINGLE- MOLECULE NANOSENSOR PLATFORM THAT PROBES AND QUANTIFIES STRUCTURALLY AND FUNCTIONALLY DIVERSE PROTEINS BEYOND THE FUNDAMENTAL LIMIT OF SENSING INSIDE THE NANOPORE. IN ADDITION, SUCH A TACTIC WILL ENABLE THE DETECTION OF COMPETING BINDING INTERACTIONS OF KINASE ISOFORMS AGAINST THE SAME RECOGNITION LIGAND. THESE GENERALIZABLE NANOSENSORS PERMIT INTEGRATION INTO SCALABLE DEVICES, REPRESENTING VERSATILE ELEMENTS FOR SMALL-MOLECULE INHIBITOR SCREENING AND DRUG DISCOVERY PIPELINES. FURTHER PROJECT DEVELOPMENTS WILL BE AIMED AT MAINTAINING A HIGH PERFORMANCE OF THESE NANOSENSORS IN A COMPLEX BIOFLUID. THEREFORE, THEY CAN BE UTILIZED USING REALISTIC SAMPLES, HAVING PROSPECTS IN MOLECULAR DIAGNOSTICS. THE EXPECTED IMMEDIATE OUTCOMES OF THIS PROJECT WILL BE THE FOLLOWING: (I) THE DEVELOPMENT OF HIGH-AFFINITY NANOSENSORS FOR ULTRASENSITIVE ANALYSIS OF RECEPTOR TYROSINE KINASES (RTKS); (II) THE CREATION OF GENETICALLY-ENCODED NANOSENSORS FOR PROBING SERINE-THREONINE KINASES (STKS); (III) THE DETECTION AND ANALYSIS OF KINASES IN MULTIPLEXED SETTINGS AND BIOFLUIDS. THESE STUDIES WILL IMPACT HEALTHCARE BY PROVIDING TOOLS AND A FUNDAMENTAL FRAMEWORK IN BIOSENSOR TECHNOLOGY, SYNTHETIC BIOLOGY, AND SINGLE-MOLECULE ENZYMOLOGY.

CELL CYCLE DEPENDENT MECHANISMS TRIGGERING LUMEN FORMATION IN VIVO - SUMMARY STATEMENT: IN HUMANS AND OTHER VERTEBRATES, MOTILE CILIA LOCATED IN AN ORGAN OF ASYMMETRY PLAY AN IMPORTANT ROLE IN CARDIAC LEFT-RIGHT DEVELOPMENT. EVIDENCE FROM MODEL ORGANISMS, SUCH AS IN ZEBRAFISH ORGAN OF ASYMMETRY, (KUPFFER’S VESICLE, KV) INDICATES THAT CONSERVED CILIA-DRIVEN LEFTWARD FLOW ESTABLISHES LEFT- RIGHT SIGNALS TO REGULATE TARGET GENES TO CONTROL ASYMMETRIC HEART MORPHOGENESIS. WHILE EVENTS DOWNSTREAM OF LEFTWARD FLOW HAVE RECEIVED MUCH ATTENTION, LITTLE IS KNOWN ABOUT HOW THE ORGAN OF ASYMMETRY IS FORMED AND THE BIOLOGY OF THE CILIATED CELLS THAT GENERATE FLUID FLOW. THIS PROJECT ADDRESSES THE BROAD QUESTION: HOW DO CILIATED CELLS DEVELOP INTO A FUNCTIONAL POLARIZED ORGAN? TO ADDRESS THIS QUESTION WE ARE BRINGING TOGETHER CELL BIOLOGY AND DEVELOPMENTAL BIOLOGY TO INVESTIGATE HOW THE CYTOKINETIC BRIDGE ESTABLISHES APICAL POLARITY AND A LUMEN IN VIVO. WE PROPOSE THAT THIS OCCURS THROUGH A SEQUENTIAL PROCESS THAT STARTS WITH CELL DIVISION AND PLACEMENT OF THE CYTOKINETIC MIDBODY, WHICH MARKS A SITE FOR WHERE THE APICAL MEMBRANE SHOULD BE PLACED. CYTOKINETIC BRIDGE RESOLUTION (A.K.A. ABSCISSION) RESULTS IN THE SEPARATION OF TWO DAUGHTER CELLS FOLLOWING MITOSIS ALLOWING FOR THE CELL TO INITIATE CILIOGENESIS. THIS PROCESS HAS IMPORTANT IMPLICATIONS IN EMBRYOGENESIS, AND BROAD IMPLICATIONS IN THE ROLE OF CYTOKINESIS IN DEVELOPING CELLULAR DIVERSITY. WHILE ABSCISSION HAS BEEN EXAMINED IN VITRO, LITTLE HAS BEEN DONE TO EXAMINE THE ROLE OF CYTOKINESIS/ABSCISSION IN EPITHELIAL ESTABLISHMENT AND DE NOVO LUMEN FORMATION IN VIVO. THUS, OUR WORK WILL TEST THE OVERALL HYPOTHESIS THAT CELL DIVISION IS AN ESSENTIAL PROCESS THAT INITIATES LUMEN FORMATION, CILIOGENESIS, AND SUBSEQUENTLY TISSUE MORPHOGENESIS. HERE WE PROPOSE TO EXAMINE IN THE ZEBRAFISH KV A REQUIREMENT FOR ABSCISSION IN THE TRANSITION OF PROGENITOR-MESENCHYMAL-LIKE MIGRATORY CELLS TO EPITHELIAL-CILIATED CELLS (TESTED IN AIM 1). FOR INSTANCE, DOES CELL DIVISION TRIGGER KV-SPECIFIC APICAL POLARITY PROTEIN EXPRESSION AND DOES DIVISION CONTRIBUTE TO HOW CELLS ARE PATTERNED TO FORM A KV? WE PROPOSE THAT FOLLOWING CYTOKINESIS, DAUGHTER CELLS STAY INTERCONNECTED BY A CYTOKINETIC BRIDGE WHILE APICAL POLARITY IS ESTABLISHED. THIS PROCESS REQUIRES TARGETED MEMBRANE TRAFFIC INTO THE CYTOKINETIC BRIDGE. DURING THIS TIME, THE TWO DAUGHTER CELLS POSITION THEMSELVES SO THAT THE CYTOKINETIC BRIDGE IS PLACED WHERE AN APICAL MEMBRANE AND LUMEN WILL FORM. ONCE THE BRIDGE IS CLEAVED, A LUMEN IS INITIATED (AIM 2) AND KV CELLS CAN FORM PRIMARY CILIA (AIM 3). WE WILL USE PHOTOCONVERSION TO TRACK CELL FATE FOLLOWING DIVISION, AND LASER ABLATION OR OPTOGENETICS TO DETERMINE WHETHER ABSCISSION TIMING IS IMPORTANT FOR APICAL POLARITY, CILIA FORMATION, AND LUMENOGENESIS. THESE STUDIES WILL IDENTIFY IMPORTANT MECHANISMS FOR DE NOVO TISSUE MORPHOGENESIS.

SYRACUSE UNIVERSITY: NEW SENSOR AWARD. CONTROL NUMBER: 1737-1570 TITLE: “MICROCAM: A LOW POWER AND PRIVACY PRESERVING MULTI-MODAL PLATFORM FOR OCCUPANCY DETECTION AND COUNTING.”

MRI CONSORTIUM: TRACK 1: DEVELOPMENT OF SPECTRUM: AN EVOLUTIONARY RAPID-PROTOTYPING TESTBED FOR LOW LATENCY MULTI-DOMAIN COMPUTING -AS ARTIFICIAL INTELLIGENCE (AI) EXPANDS INTO FIELDS SUCH AS HEALTHCARE, ROBOTICS, AND ENERGY DISTRIBUTION, THERE IS GROWING DEMAND FOR FASTER, COST-EFFECTIVE WAYS TO PROTOTYPE AI HARDWARE. GRAPHICS PROCESSING UNITS (GPUS) OFFER HIGH THROUGHPUT BUT OFTEN STRUGGLE TO MEET THE LOW LATENCY NEEDED FOR REAL-TIME DECISIONS. FIELD-PROGRAMMABLE GATE ARRAYS (FPGAS) PROVIDE LOWER LATENCY BUT CAN SUBSTANTIALLY SACRIFICE THROUGHPUT. THE KEY CHALLENGE IS MAPPING AI ALGORITHMS TO THE RIGHT ACCELERATOR. THE SPECTRUM PROJECT ESTABLISHES A TESTBED THAT COMBINES GPUS AND FPGAS, BOTH EQUIPPED WITH EMBEDDED TENSOR PROCESSING CORES, TO HELP REDUCE LATENCY. USING THE CHARM TOOL, DEVELOPERS CAN USE THE SPECTRUM TESTBED TO QUICKLY TEST HARDWARE SETUPS FOR REAL-TIME AI SYSTEMS LIKE AUTONOMOUS VEHICLES. SPECTRUM ADVANCES THE STATE OF AI SYSTEM PROTOTYPING, PARTICULARLY FOR LOW LATENCY DESIGNS, THROUGH THE DEVELOPMENT OF ITS RECONFIGURABLE TESTBED COMPOSED OF FPGAS (E.G., AMD VERSAL ACAPS) AND GPUS (E.G, NVIDIA HOPPER/BLACKWELL GPUS), WHICH CONTAIN EMBEDDED TENSOR CORES. THE CHARM FLOW AUTOMATICALLY PARTITIONS THE AI COMPUTATION BETWEEN THE TRADITIONAL ACCELERATOR HARDWARE AND THE EMBEDDED TENSOR CORES. THE WORK IS ORGANIZED INTO THREE THRUSTS: (1) ACQUISITION AND INTEGRATION OF HYBRID ACCELERATORS SUPPORTING BOTH EDGE AND DATA-CENTER CONFIGURATIONS; (2) EXTENSION OF THE CHARM HW/SW FRAMEWORK TO ENABLE AUTOMATED, DOMAIN-SPECIFIC ACCELERATOR SYNTHESIS ACROSS HETEROGENEOUS PLATFORMS; AND (3) CREATION OF A USER-FACING SPECTRUM APPLICATION INTERFACE FOR DEPLOYMENT AND EVALUATION. THE INFRASTRUCTURE ENABLES SCALABLE, LOW-LATENCY (<10MS), END-TO-END AI ACCELERATOR DESIGN, SIGNIFICANTLY LOWERING THE BARRIER TO ENTRY FOR DOMAIN EXPERTS IN REAL-TIME, SAFETY-CRITICAL APPLICATIONS. SPECTRUM HAS SO FAR DEVELOPED AN INTERESTED USER BASE FROM RESEARCH EFFORTS ACROSS 26 GROUPS AT 16 INSTITUTIONS, DELIVERING CRITICAL NATIONAL INFRASTRUCTURE FOR REAL-TIME AI SYSTEM DESIGN. ACCESS WILL BE PROVIDED DIRECTLY FROM THE LEAD SITE AT SYRACUSE UNIVERSITY AND INTEGRATION IS PLANNED INTO THE FABRIC NETWORK. A KEY OUTREACH STRATEGY INCLUDES HANDS-ON WORKSHOPS AND TUTORIALS AT MAJOR CONFERENCES IN SUPERCOMPUTING, COMPUTER SYSTEMS, DESIGN AUTOMATION, AND FPGAS TO TRAIN A BROAD USER BASE. ONLINE COURSES WILL SUPPORT WORKFORCE DEVELOPMENT ACROSS SKILL LEVELS. THE TESTBED WILL BE INTEGRATED INTO UNDERGRADUATE AND GRADUATE CURRICULA AT SYRACUSE, BROWN UNIVERSITY, AND UNIVERSITY OF PITTSBURGH, AND WILL SUPPORT INTERDISCIPLINARY COLLABORATIONS AND K?12 OUTREACH INITIATIVES FOCUSED ON AI HARDWARE AND REAL-TIME COMPUTING. TO SUPPORT LONG-TERM COMMUNITY ENGAGEMENT AND REPRODUCIBILITY, THE PROJECT TEAM WILL DEVELOP AND MAINTAIN A PUBLIC-FACING WEBSITE AT HTTPS://SPECTRUM-AI.ORG, WHICH WILL SERVE AS THE CENTRAL HUB FOR DOCUMENTATION, DATASETS, TUTORIALS, BENCHMARK RESULTS, AND APPLICATION DEPLOYMENT WORKFLOWS. ALL SOFTWARE TOOLS, INCLUDING THE CHARM FRAMEWORK, WILL BE HOSTED ON GITHUB AND LINKED FROM THE MAIN SITE. THE PROJECT TEAM WILL ENSURE THAT THE WEBSITE AND REPOSITORIES REMAIN ACCESSIBLE AND MAINTAINED FOR AT LEAST FIVE YEARS BEYOND THE OPERATIONAL LIFETIME OF THE PHYSICAL TESTBED, SUPPORTING CONTINUED USE BY RESEARCHERS, EDUCATORS, AND STUDENTS IN REAL-TIME AI SYSTEM DESIGN. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

THE IMPACT OF SCHOOL FOOD POLICY ON CHILDHOOD OBESITY

INDUSTRIAL ASSESSMENT CENTER AT SYRACUSE UNIVERSITY

RONALD E. MCNAIR POSTBACCALAUREATE ACHIEVEMENT

RONALD E. MCNAIR POST-BACCALAUREATE ACHIEVEMENT

INVESTIGATION OF LONG-RANGE CHARGE TRANSFER AND EXCITED STATE PROCESSES IN BIOCHEMICAL SYSTEMS - PROJECT SUMMARY/ABSTRACT IN THIS MIRA PROGRAM, WE AIM TO GAIN ATOMIC-LEVEL INSIGHTS INTO COMPLEX BIOLOGICAL SYSTEMS SUCH AS BACTERIAL MEMBRANE PROTEINS AND LIGHT-SENSITIVE PROTEINS WITH PARTICULAR EMPHASIS ON THEIR NATIVE PROTEIN AND LIPID ENVIRONMENTS. WE WILL TEST THE IMPACT OF SUCH BIOCHEMICAL ENVIRONMENTS IN TWO DISTINCT PROJECTS. A WIDE VARIETY OF TOXIC CHEMICALS, INCLUDING TOXIC METAL OXIDES AND HYDROXIDES, POLLUTE OUR ENVIRONMENT, POSING AN IMMINENT THREAT TO HUMAN LIFE. ONE CAN LEVERAGE THE UNIQUE RESPIRATION MECHANISM IN MARINE MICROBES LIKE SHEWANELLA TO REVOLUTIONIZE BIOREMEDIATION AND WASTEWATER TREATMENT TECHNOLOGY. MOLECULAR MODELING AND COMPUTATIONS WILL PROVIDE AN ATOMIC-SCALE COMPREHENSION OF THE MECHANISM THAT WILL AUGMENT MACROSCALE EXPERIMENTAL OBSERVABLES. IN THE FIRST PROJECT, WE WILL MODEL THE OUTER MEMBRANE CYTOCHROME-PORIN COMPLEX OF SHEWANELLA ONEIDENSIS IN ITS NATIVE ENVIRONMENT AND OBTAIN MOLECULAR INSIGHTS INTO THE CHARGE-TRANSFER NETWORK EMPLOYED IN ITS RESPIRATION. ELECTRONICALLY EXCITED-STATE PROCESSES ARE UBIQUITOUS IN NATURE AND BIOTECHNOLOGY. FOR EXAMPLE, BLUE-LIGHT-SENSITIVE PROTEINS ARE USED IN THE OPTOGENETIC CONTROL OF CELLULAR PROCESSES. FLUORESCENT PROTEINS WITH EMISSIONS SPANNING THE ENTIRE VISIBLE REGION ARE OFTEN UTILIZED FOR IN VIVO IMAGING. IN THESE APPLICATIONS, SUBTLE STRUCTURAL CHANGES IN AN ELECTRONICALLY EXCITED MOLECULE INDUCE PRONOUNCED CONFORMATIONAL CHANGES IN THE NEARBY PROTEIN ENVIRONMENT OR FURTHER FROM ITS LOCATION (ALLOSTERY). THEREFORE, THE BIOCHEMICAL ENVIRONMENT RELAYS THE INFORMATION AT THE PHOTON-ABSORPTION SITE TO ANOTHER SITE. MOST CONFORMATIONAL CHANGES OCCUR WELL BEYOND A FEW NANOSECONDS, MAKING THEM INACCESSIBLE TO MODERN MULTI-SCALE QUANTUM MECHANICS/MOLECULAR MECHANICS (QM/MM) TECHNIQUES. THEREFORE, IN THE SECOND PROJECT, WE WILL BUILD A TOOL TO MODEL EXCITED STATES OF BIOMOLECULES USING FORCE FIELD PARAMETERS AND THEN VALIDATE THOSE PARAMETERS USING A FEW CASE STUDIES WITH FLUORESCENT PROTEINS. FURTHERMORE, WE WILL USE THOSE PARAMETERS TO DECIPHER PHOTOINDUCED ALLOSTERIC PATHWAYS IN BLUE-LIGHT-SENSITIVE PROTEINS.

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

TAS::89 0331::TAS RECOVERY EERE NEW AWARD DE-EE0003844 WITH SYRACUSE UNIVERSITY FOR A PROJECT TITLED, "RECOVERY ACT: DEVELOPMENT OF AN INTEGRATED COM

PREPARATION OF LEADERSHIP PERSONNEL

B2B-2024 SYRACUSE UNIVERSITY IVMF

ANTIMICROBIAL SHAPE MEMORY POLYMER FOAMS FOR RAPID HEMORRHAGE CONTROL AND INFECTION PREVENTION IN TRAUMATIC WOUNDS

RONALD E. MCNAIR POST BACCALAUREATE ACHIEVEMENT PROGRAM 2022 GRANT APPLICATION

PHASE I IUCRC SYRACUSE UNIVERSITY: CENTER FOR ALTERNATIVE SUSTAINABLE AND INTELLIGENT COMPUTING (ASIC)

GERMLINE SILENCING OF UNPAIRED CHROMATIN

B2B-2025 SYRACUSE UNIVERSITY IVMF

RELATIONSHIPS AMONG INTERPERSONAL STRESS, AFFECT REGULATION, AND ALCOHOL LAPSE

CIF21 DIBBS: DOMAIN-AWARE MANAGEMENT OF HETEROGENEOUS WORKFLOWS: ACTIVE DATA MANAGEMENT FOR GRAVITATIONAL-WAVE SCIENCE WORKFLOWS

NEUTRINO RESEARCH AT SYRACUSE UNIVERSITY -ONE OF THE MAJOR INTELLECTUAL ACHIEVEMENTS OF THE 20TH CENTURY WAS THE DEVELOPMENT OF THE STANDARD MODEL (SM) OF PARTICLE PHYSICS. THIS MODEL SUCCEEDED IN CLASSIFYING ALL OF THE ELEMENTARY PARTICLES KNOWN AT THE TIME INTO A HIERARCHY OF GROUPS HAVING SIMILAR QUANTUM PROPERTIES. THE VALIDITY OF THIS MODEL TO DATE WAS CONFIRMED BY THE DISCOVERY OF THE HIGGS BOSON AT THE LARGE HADRON COLLIDER AT CERN. HOWEVER, THE STANDARD MODEL AS IT CURRENTLY EXISTS LEAVES OPEN MANY QUESTIONS ABOUT THE UNIVERSE, INCLUDING SUCH FUNDAMENTAL QUESTIONS AS TO WHY THE HIGGS MASS HAS THE VALUE IT HAS AND WHY THERE IS NO ANTIMATTER IN THE UNIVERSE. ONE OF THE PRIMARY AREAS TO SEARCH FOR ANSWERS TO THESE AND OTHER OPEN QUESTIONS ABOUT THE UNIVERSE, HOW IT CAME TO BE AND WHY IT IS THE WAY IT IS, IS TO FOCUS ON A STUDY OF THE PROPERTIES OF NEUTRINOS AND TO USE WHAT WE KNOW AND CAN LEARN ABOUT NEUTRINOS AS PROBES OF SCIENCE BEYOND THE STANDARD MODEL. NEUTRINOS ARE THOSE ELEMENTARY PARTICLES THAT INTERACT WITH PRACTICALLY NOTHING ELSE IN THE UNIVERSE. THEY HAVE NO ELECTRIC CHARGE AND WERE ONCE THOUGHT TO BE MASSLESS. WE NOW KNOW THERE ARE THREE KINDS OF NEUTRINOS THAT ARE DISTINGUISHABLE THROUGH THE DIFFERENT INTERACTIONS THAT THEY UNDERGO WHENEVER THERE IS AN INTERACTION. WE ALSO KNOW THAT NEUTRINOS DO HAVE A MASS AND BECAUSE THEY DO, THEY CAN ACTUALLY CHANGE FROM ONE TYPE TO ANOTHER. DETAILED MEASUREMENTS OF THESE CHANGES, ALONG WITH OTHER CURRENT NEUTRINO EXPERIMENTS, FORM ONE OF THE MOST PROMISING WAYS TO PROBE FOR NEW PHYSICS BEYOND THE STANDARD MODEL. SUCH MEASUREMENTS LIE AT THE HEART OF THIS PROJECT WHICH INCLUDE ACTIVITIES OF THE SYRACUSE UNIVERSITY NEUTRINO GROUP ON THE MICROBOONE, NOVA, SBND, AND DUNE EXPERIMENTS. THESE ACTIVITIES INCLUDE MEASUREMENTS WITH NOVA?S TEST BEAM THAT WILL IMPACT THE EXPERIMENT?S ABILITY TO RESOLVE THE NEUTRINO MASS HIERARCHY; ON THE MICROBOONE EXPERIMENT, ANALYSES OF LOW-ENERGY ACTIVITY THAT HAS RELEVANCE FOR SUPERNOVA PHYSICS AND BASIC NEUTRINO INTERACTION STUDIES, AND ON THE DUNE EXPERIMENT THE GROUP WILL MAKE SIGNIFICANT CONTRIBUTIONS TO THE CONSTRUCTION OF THE ANODE PLANE ASSEMBLIES NEEDED TO REALIZE THIS ENORMOUS DETECTOR. THERE IS CURRENTLY A LARGE INTEREST IN EXPERIMENTAL PARTICLE PHYSICS IN LIQUID ARGON TIME PROJECTION CHAMBERS (LARTPC) SPURRED IN PART BY THE DUNE PROJECT AT FERMI NATIONAL ACCELERATOR LABORATORY (FNAL) AND IN NEUTRINO PHYSICS IN GENERAL. THIS AWARD SUPPORTS WORK THAT REFINES LARTPC TECHNOLOGY, USING A TEST BEAM AND AT THE MICROBOONE EXPERIMENT AT FNAL. LARTPC DETECTOR TECHNOLOGY IS SCALABLE TO THE VERY LARGE MASSES (PERHAPS 10 KILOTONS) NEEDED BY NEXT GENERATION NEUTRINO EXPERIMENTS AND IS CAPABLE OF RECORDING THREE-DIMENSIONAL DIGITAL IMAGES OF PARTICLE TRAJECTORIES. MICROBOONE IS MAKING A VARIETY OF INTERESTING PHYSICS MEASUREMENTS, AS WELL AS SERVING AS A PROVING GROUND FOR NEW HARDWARE TECHNIQUES RELEVANT FOR FUTURE EXPERIMENTS. ANOTHER ASPECT OF THE WORK IN THIS AWARD IS THE ANALYSIS OF DATA FROM A LARGE LARTPC DETECTOR AT CERN CALLED PROTODUNE. THE LESSONS LEARNED HERE WILL INFORM THE FUTURE DUNE DETECTOR DESIGN. THE BROADER IMPACT OF THIS WORK WILL INVOLVE UNDERGRADUATES, GRADUATE STUDENTS, AND POSTDOCTORAL RESEARCHERS, ALL OF WHOM WILL RECEIVE VALUABLE EXPERIENCE AND TRAINING IN EXPERIMENTAL RESEARCH THAT WILL BE APPLICABLE IN THEIR FUTURE CAREER TRAJECTORIES. THE SYRACUSE GROUP WILL CONTINUE WITH SEVERAL OUTREACH EFFORTS AS PART OF THIS AWARD. THE PUBLIC WILL BE INFORMED ABOUT THE EXCITING RESEARCH IN PARTICLE PHYSICS VIA THE HOSTING OF IN-PERSON MASTERCLASS ACTIVITIES. FINALLY, THE GROUP WILL TAKE ADVANTAGE OF SYRACUSE UNIVERSITY?S UNIQUE COMMITMENT TO THE EDUCATION OF VETERANS OF THE U.S. ARMED SERVICES AND ENGAGE THIS POPULATION OF STUDENTS IN THE DUNE HARDWARE EFFORTS ON CAMPUS, PROVIDING VALUABLE TECHNICAL AND SCIENTIFIC TRAINING. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

DEFINING THE MOLECULAR ARCHITECTURE FOR TRANSMEMBRANE ACYLATION BY A MEMBRANE BOUND O-ACYLTRANSFERASE

RESEARCH PROGRAM IN ELEMENTARY PARTICLE THEORY

DESCRIPTION:THIS AGREEMENT PROVIDES FUNDING TO SUPPORT THE ENVIRONMENTAL FINANCE CENTER (EFC) AT SYRACUSE UNIVERSITY TO IMPLEMENT ITS PROJECT TO LEAD A DIVERSE TEAM OF PARTNERS TO EFFECTIVELY DELIVER TRAINING, ASSISTANCE, AND CAPACITY BUILDING ACTIVITIES ACROSS EPA REGION 2. SYRACUSE UNIVERSITY WILL ALSO ASSIST COMMUNITIES BY PROVIDING TECHNICAL SERVICES AND ENGINEERING, TRAINING AND EVENT COORDINATION, AND COMMUNITY ENGAGEMENT SUPPORT. THE EFCS PROVIDE FINANCE-RELATED TRAINING, EDUCATION, AND ANALYTICAL STUDIES TO HELP REGULATED PARTIES DEVELOP SOLUTIONS TO THE DIFFICULT 'HOW-TO-PAY' ISSUES ASSOCIATED WITH MEETING ENVIRONMENTAL STANDARDS. THE EFCS EDUCATE STATE, TRIBAL, AND LOCAL GOVERNMENTS AND BUSINESSES ON LOWERING ENVIRONMENTAL COSTS, INCREASING ENVIRONMENTAL INVESTMENTS, IMPROVING FINANCIAL CAPACITY, IDENTIFYING APPROPRIATE REVENUE GENERATING MECHANISMS, AND EVALUATING ENVIRONMENTAL FINANCING OPTIONS. ACTIVITIES:THE ACTIVITIES TO BE PERFORMED ARE DELIVERING INNOVATIVE TRAINING AND CAPACITY BUILDING IN FOUR OVERARCHING PROGRAM AREAS: A. WATER INFRASTRUCTURE AND EQUITY PLANNING PROGRAM (WIEPP), B. RESOURCE CONSERVATION AND SUSTAINABLE MATERIALS MANAGEMENT COMMUNITY ASSISTANCE (SMMCA), C. AQUATIC DEBRIS PREVENTION PROGRAM (ADPP), AND D. COLLABORATIVE CLIMATE CHANGE PLANNING (C3P). THERE WILL ALSO BE A FIFTH PROGRAM AREA, E. COMMUNITY GRANTS TECHNICAL ASSISTANCE, BASED ON ADDITIONAL AVAILABLE FUNDING. SUBRECIPIENT:THERE WILL BE A SUBAWARD FOR UNIVERSITY OF PUERTO RICO - RIO PIEDRAS TO PROVIDE WATER QUALITY RESEARCH AND TECHNICAL ASSISTANCE. THEY WILL ALSO WORK WITH SYRACUSE UNIVERSITY TO PROVIDE CAPACITY-BUILDING SERVICES TO THE COMMUNITY OF LAS CURIAS, PUERTO RICO TO PROTECT AND RESTORE LOCAL WATER RESOURCES IN THE LAS CURIAS SUBWATERSHED. OUTCOMES:THE ANTICIPATED DELIVERABLES ARE INDIVIDUALIZED TECHNICAL ASSISTANCE, PARTNERSHIP BUILDING, NETWORK DEVELOPMENT, AND DEVELOPMENT OF SCIENCE-DRIVEN DECISION-SUPPORT TOOLS, WHICH ARE EXPECTED TO LEAD TO THE ENHANCEMENT OF ACCESS TO INFRASTRUCTURE FUNDING, THE IMPLEMENTATION OF BEST PRACTICES IN RESOURCE CONSERVATION, AND THE PROTECTION OF PUBLIC HEALTH FOR COMMUNITIES IN REGION 2, ESPECIALLY FOR DISADVANTAGED, RURAL AND/OR NATIVE COMMUNITIES.

QUANTITATIVE MODELING OF CELL SHAPE CHANGES DURING ORGANOGENESIS

FY24 CONGRESSIONAL COMMUNITY PROJECT FUNDING- SYRACUSE UNIVERSITY

LOUIS STOKES RENEWAL STEM PATHWAYS AND RESEARCH ALLIANCE: NEW YORK STATE'S UPSTATE LSAMP (ULSAMP) -THE OVERALL GOAL OF THE LOUIS STOKES ALLIANCES FOR MINORITY PARTICIPATION (LSAMP) PROGRAM IS TO ASSIST UNIVERSITIES AND COLLEGES IN DIVERSIFYING THE NATION'S SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS (STEM) WORKFORCE BY INCREASING THE NUMBER OF STEM BACCALAUREATE AND GRADUATE DEGREES AWARDED TO PERSONS FROM LSAMP POPULATIONS LSAMP POPULATIONS ARE DEFINED AS PERSONS FROM GROUPS UNDERREPRESENTED IN THE STEM ENTERPRISE: BLACKS AND AFRICAN-AMERICANS, HISPANIC AND LATINO AMERICANS, AMERICAN INDIANS, ALASKA NATIVES, NATIVE HAWAIIANS, AND PACIFIC ISLANDERS. THE UPSTATE LOUIS STOKES ALLIANCE FOR MINORITY PARTICIPATION (ULSAMP) IS LED BY SYRACUSE UNIVERSITY. SIX PARTNER INSTITUTIONS IN NEW YORK PARTICIPATE IN THE ALLIANCE: CLARKSON UNIVERSITY, CORNELL UNIVERSITY, MONROE COMMUNITY COLLEGE (MCC), ONONDAGA COMMUNITY COLLEGE (OCC), RENSSELAER POLYTECHNIC INSTITUTE (RPI), AND ROCHESTER INSTITUTE OF TECHNOLOGY (RIT). THE PROJECT GOALS ARE TO 1) INSTITUTIONALIZE PROMISING PRACTICES FOR INCREASING THE NUMBER OF STUDENTS FROM LSAMP POPULATIONS IN STEM MAJORS; 2) EXPAND AND REFINE PRACTICES TO INCREASE THE NUMBER OF UNDERREPRESENTED STUDENTS ENTERING STEM CAREERS OR GRADUATE-LEVEL PROGRAMS; AND 3) CONDUCT AND DISSEMINATE SCHOLARLY RESEARCH TO ASSESS THE IMPACT OF RESEARCH EXPERIENCES FOR UNDERGRADUATES (REUS) ON GRADUATE ENROLLMENT AND COMPLETION. SEVERAL INDUSTRIES WILL COLLABORATE WITH THE ALLIANCE OVER THE NEXT FIVE YEARS TO PROVIDE RESEARCH OPPORTUNITIES INCLUDING MICRON TECHNOLOGY, NATIONAL RENEWABLE ENERGY LABORATORY, REGENERON PHARMACEUTICALS AND NATIONAL GRID, AMONG OTHERS. ULSAMP WILL MEET THESE GOALS BY OFFERING STUDENT SUPPORTS AND RESEARCH OPPORTUNITIES IN THREE CATEGORIES: 1) BRIDGE INITIATIVES; 2) RETENTION AND GRADUATION INITIATIVES; AND 3) GRADUATE SCHOOL ENROLLMENT INITIATIVES. ULSAMP WILL STRENGTHEN ITS ALLIANCE BY IMPROVING ITS SHARED ACTIVITIES, PROVIDING RESOURCES AND INCORPORATING BEST PRACTICES TO INSTITUTIONALIZE ALLIANCE PRACTICES AND ACTIVITIES. IN ADDITION TO BRIDGE PROGRAMS, RECRUITMENT AND RETENTION ACTIVITIES INCLUDE THE COMMUNITY COLLEGE RESEARCH SCHOLARS PROGRAM, SUMMER MATH INSTITUTES, POWER LABS, STUDENT RESEARCH CONFERENCES, GRADUATE SCHOOL EXAMINATION AND APPLICATION SUPPORT AND GRADUATE SCHOOL FAIRS AND VISITS. THE PROJECT WILL GENERATE NEW KNOWLEDGE RELATED TO THE RECRUITMENT, ACADEMIC SUCCESS, AND PERSISTENCE OF LSAMP POPULATIONS, PARTICULARLY THE PATHWAY TO STEM GRADUATE STEM PROGRAMS IN ITS INVESTIGATION OF ASPIRATIONS, PATHWAYS AND OUTCOMES OF ALLIANCE PARTICIPANTS PREPARING FOR ENTRY INTO STEM GRADUATE PROGRAMS. ULSAMP WILL CONTRIBUTE INNOVATIVE METHODS AND APPROACHES TO MEET THE CRISIS OF EDUCATING MORE STEM WORKERS FROM DIVERSE POPULATIONS AT CRITICAL JUNCTURES IN STEM EDUCATION. PROJECT FINDINGS FROM EXTERNAL EVALUATION AND OUTCOMES OF THE RESEARCH STUDY WILL BE DISSEMINATED BROADLY THROUGH STEM JOURNALS, CONFERENCES, SOCIAL MEDIA AND WEBSITES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

SPECIAL EDUCATION-PERSONNEL PREPARATION TO IMPROVE SERVICES AND RESULTS FOR CHILDREN WITH DISABILITIES - PREPARATION OF LEADERSHIP PERSONNEL

THE STRATEGIC UNDERGRADUATE STEM TALENT ACCELERATION INITIATIVE (SUSTAIN)

TAS::89 0321::TAS - ENERGY INNOVATIONS FOR HEALTHY BUILDINGS.

FROM DETECTOR HARDWARE TO ASTROPHYSICS: AN OPEN CONTROL AND ANALYSIS ARCHITECTURE FOR COSMIC EXPLORER -THIS AWARD SUPPORTS THE DESIGN OF AN OPEN CONTROL AND ANALYSIS ARCHITECTURE FOR COSMIC EXPLORER, THE CONCEPT FOR A NEXT-GENERATION GRAVITATIONAL-WAVE OBSERVATORY IN THE U.S. COSMIC EXPLORER WILL PUSH THE REACH OF GRAVITATIONAL-WAVE ASTRONOMY TO THE EDGE OF THE OBSERVABLE UNIVERSE, ENABLING TRANSFORMATIVE DISCOVERIES ACROSS PHYSICS, ASTRONOMY, AND COSMOLOGY. THE OPEN CONTROL AND ANALYSIS ARCHITECTURE IS A CRITICAL SYSTEM THAT SITS BETWEEN THE HARDWARE SENSING GRAVITATIONAL WAVES AND THE SCIENTIFIC OUTPUT OF THE DETECTOR. THE DESIGN OF COSMIC EXPLORER?S DIGITAL SYSTEMS WILL DRIVE ADVANCEMENTS IN TECHNOLOGIES RELEVANT TO OTHER FIELDS OF SCIENCE AND INDUSTRY, INCLUDING CONTROL SYSTEMS FOR LARGE-SCALE EXPERIMENTS; ARCHITECTURES FOR LARGE-SCALE SCIENTIFIC COMPUTING; AND INVESTIGATION, ADOPTION, AND IMPROVEMENT OF OPEN-SOURCE AND INDUSTRIAL HARDWARE AND SOFTWARE SYSTEMS. THIS AWARD WILL HELP RECRUIT AND TRAIN STUDENTS AND PROFESSIONALS WHO WILL BECOME MEMBERS OF THE U.S. STEM WORKFORCE. COSMIC EXPLORER WILL DELIVER NEW DISCOVERIES, DRAMATICALLY INCREASE THE NUMBER OF OBSERVATIONS, AND BEGIN THE ERA OF PRECISION GRAVITATIONAL-WAVE SCIENCE. THE OPEN CONTROL AND ANALYSIS ARCHITECTURE WILL BE RESPONSIBLE FOR RUNNING THE HIGH-BANDWIDTH, HIGH-PERFORMANCE CONTROL LOOPS THAT KEEP THE DETECTORS OPERATING, SYNCHRONIZING THE DETECTOR AS PART OF A GLOBAL NETWORK WITH EXQUISITE TIMING PRECISION, TRANSLATING THE MEASURED ELECTRICAL SIGNALS INTO TO VARIOUS KINDS OF ASTROPHYSICALLY RELEVANT OUTPUTS, AND ALLOWING HUMAN INSIGHT AND CONTROL INTO THE DETECTOR?S OPERATION AND PERFORMANCE. TWO KEY ASPECTS OF THE PROPOSED DESIGN ARE TO MAKE THE ARCHITECTURE INTEGRATED SO THAT ASTROPHYSICS IS INTEGRATED WITH THE OPERATION OF THE DETECTOR AND OPEN SO THAT THE SCIENTIFIC COMMUNITY CAN CONTRIBUTE TO AND EXTEND COSMIC EXPLORER'S SCIENCE GOALS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

EXPLORATIONS: QUANTUM AND SEMICONDUCTOR UPSKILLING FOR CAREER CHANGE THROUGH EXPERIENTIAL EDUCATION DEPLOYMENT IN CENTRAL NEW YORK (Q-SUCCEED-CNY) -THE RAPID GROWTH OF SEMICONDUCTOR MANUFACTURING, QUANTUM TECHNOLOGIES, AND OPTICS OFFERS A VITAL OPPORTUNITY TO STRENGTHEN REGIONAL ECONOMIC DEVELOPMENT AND WORKFORCE CAPACITY IN CENTRAL NEW YORK. YET MANY ADULTS FACE BARRIERS TO ENTERING THESE HIGH-DEMAND FIELDS DUE TO LIMITED EXPOSURE, FINANCIAL CONSTRAINTS, AND UNCLEAR PATHWAYS INTO EDUCATION AND TRAINING. THIS PROJECT EXPANDS ACCESS TO THESE EMERGING TECHNOLOGIES BY PROVIDING FLEXIBLE, HANDS-ON LEARNING OPPORTUNITIES THAT BUILD TECHNICAL SKILLS, CAREER NAVIGATION STRATEGIES, AND INDUSTRY CONNECTIONS. BY OPENING PATHWAYS INTO THESE HIGH-TECH INDUSTRIES, THE PROJECT ADVANCES STEM EDUCATION, ENHANCES ECONOMIC RESILIENCE, AND SUPPORTS THE PROGRESS OF SCIENCE BY PREPARING INDIVIDUALS FOR MEANINGFUL CAREERS. THIS INITIATIVE BENEFITS SOCIETY BY HELPING LOCAL RESIDENTS PURSUE NEW OPPORTUNITIES IN ADVANCED TECHNOLOGY SECTORS OF SEMICONDUCTORS AND QUANTUM, ENSURING THAT THE REGION CAN FULLY CONTRIBUTE TO THE NATION?S SCIENTIFIC AND ECONOMIC GROWTH. THE PROJECT WILL DEVELOP AND DELIVER A HYBRID CURRICULUM INTRODUCING ADULT LEARNERS TO EMERGING FIELDS IN SEMICONDUCTORS, QUANTUM TECHNOLOGIES, AND OPTICS THROUGH EXPERIENTIAL, PROBLEM-BASED LEARNING. INSTRUCTION WILL INCORPORATE FOUNDATIONAL TECHNICAL CONCEPTS, HANDS-ON LABORATORY EXPERIENCES, AND EXPOSURE TO INDUSTRY-RELEVANT PROCESSES AND TOOLS. RECRUITMENT WILL FOCUS ON ADULT LEARNERS THROUGH PARTNERSHIPS WITH COMMUNITY ORGANIZATIONS AND WORKFORCE AGENCIES, PROVIDING FLEXIBLE, IN-PERSON AND VIRTUAL ENGAGEMENT OPPORTUNITIES. PARTICIPANTS WILL RECEIVE FINANCIAL SUPPORT, PERSONALIZED MENTORING, AND CAREER NAVIGATION ASSISTANCE TO PROMOTE PARTICIPATION AND COMPLETION. A MULTI-YEAR EVALUATION PLAN WILL TRACK GROWTH IN TECHNICAL SKILLS, CONFIDENCE IN STEM LEARNING, AND PARTICIPANT ENGAGEMENT WITH INDUSTRY PATHWAYS. ACTIVE COLLABORATION WITH INDUSTRY PARTNERS WILL GUIDE CURRICULUM UPDATES AND ENSURE ALIGNMENT WITH EVOLVING WORKFORCE NEEDS WHILE OFFERING MENTORSHIP AND NETWORKING OPPORTUNITIES. OUTCOMES AND INSTRUCTIONAL RESOURCES WILL BE SHARED THROUGH AN OPEN-ACCESS PLATFORM TO ENCOURAGE BROADER ADOPTION OF EFFECTIVE, HANDS-ON STEM LEARNING MODELS FOR NON-TRADITIONAL LEARNERS. THE EXLENT PROGRAM, SUPPORTED BY THE NSF TIP AND EDU DIRECTORATES, SEEKS TO SUPPORT EXPERIENTIAL LEARNING OPPORTUNITIES FOR INDIVIDUALS TO INCREASE THEIR INTEREST IN AND ACCESS TO CAREER PATHWAYS IN EMERGING TECHNOLOGY FIELDS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

TAS::57 3600::TAS "NEW SYNTHETIC AND ASSEMBLY METHODOLOGY FOR GUIDING NANOMATERIAL ASSEMBLY WITH HIGH FIDELITY INTO ID CLUSTERS AND 3D CRYSTALS USING

B2B IVMF SYRACUSE UNIV.

EXPLORATIONS: SYRACUSE UNIVERSITY PHYSICS EMERGING RESEARCH TECHNOLOGIES SUMMER HIGH SCHOOL INTERNSHIP PROGRAM (SUPER-TECH SHIP) -THE HIGH-TECH INDUSTRIES OF THE FUTURE NEED TRAINED WORKERS WHO ARE EXCITED ABOUT SCIENCE AND TECHNOLOGY. SYRACUSE IS A CITY THAT IS RIPE FOR OPPORTUNITIES, AND RECENT ECONOMIC DEVELOPMENTS IN THE TECHNOLOGY SECTOR LOCALLY INDICATE THAT THE CITY NEEDS A WELL-TRAINED TECHNOLOGICAL WORKFORCE TO MEET THE FUTURE DEMAND. THE PHYSICS DEPARTMENT AT SYRACUSE UNIVERSITY HAS AN EPIC GOAL TO BECOME A TOUCHSTONE FOR HISTORICALLY EXCLUDED GROUPS IN PHYSICS, FOCUSING ON BLACK, LATINO, INDIGENOUS, AND WOMEN STUDENTS. TO ACHIEVE THAT GOAL, THE PROPOSED SYRACUSE UNIVERSITY PHYSICS EMERGING RESEARCH TECHNOLOGIES SUMMER HIGH SCHOOL INTERNSHIP PROGRAM (SUPER-TECH SHIP) WILL CONNECT STUDENTS TO THE EXPOSURE, KNOWLEDGE, AND SKILLS THEY NEED FOR THE QUANTUM, SEMICONDUCTOR, AND BIOTECH OPPORTUNITIES THAT ARE GROWING LOCALLY. SUPER-TECH SHIP IS A PAID SUMMER HIGH SCHOOL RESEARCH INTERNSHIP PROGRAM FOR STUDENTS FROM LOCAL AREA HIGH SCHOOLS IN THE CITY OF SYRACUSE AND SURROUNDING AREAS OF CENTRAL NEW YORK. THE PROGRAM WILL MEET STUDENTS WHERE THEY ARE AND INVITE AND WELCOME THEM INTO OUR RESEARCH COMMUNITY TO HELP THEM SEE THEMSELVES IN THESE ROLES. THE SUPER-TECH SHIP PROGRAM IS AN ESSENTIAL COMPONENT FOR FACILITATING STUDENTS? FIRST STEP FROM HIGH SCHOOL INTO TECHNOLOGICAL CAREERS THROUGH DIRECT EXPOSURE TO SEVERAL EMERGENT TECHNOLOGY FIELDS. THE SYRACUSE AREA HAS A RAPIDLY EXPANDING INDUSTRIAL FOOTPRINT FOR THESE EMERGING FIELDS, AND THESE HIGH-TECH SECTORS WILL NEED A WORKFORCE THAT UNDERSTANDS TECHNOLOGY. SYRACUSE PHYSICS IS UNIQUELY POSITIONED TO BUILD A DIVERSE WORKFORCE FOR EMERGING TECHNOLOGIES BECAUSE OUR REGION HAS A HIGH POPULATION OF HISTORICALLY EXCLUDED GROUPS, THERE IS AN OUTSTANDING RESEARCH UNIVERSITY WITH EXCELLENT SCIENTISTS WORKING IN EMERGING TECHNOLOGICAL FIELDS, THERE IS A WONDERFUL TOWN-GOWN RELATIONSHIP, AND THERE ARE LOCAL INDUSTRIES AND RESEARCH LABS IN NEED OF MANY TECHNICAL WORKERS. LEVERAGING ALL THIS, SUPER-TECH SHIP WILL CREATE THE PIPELINE FOR A DIVERSE FUTURE WORKFORCE TO THE BENEFIT OF THE INDUSTRIES AND THE LOCAL COMMUNITY. THIS IS AN EXLENT EXPLORATIONS PROPOSAL TO EXPOSE HIGH SCHOOL STUDENTS TO THE SKILLS AND CONCEPTS OF EMERGING TECHNOLOGY FIELDS FOUND IN THE SYRACUSE UNIVERSITY PHYSICS DEPARTMENT INCLUDING: QUANTUM INFORMATION, SEMICONDUCTORS, AND BIOTECHNOLOGY. THIS PROJECT IS A MAJOR PARTNERSHIP WITH SYRACUSE CITY SCHOOL DISTRICT (SCSD), AN INNER-CITY DISTRICT WITH HIGH NUMBERS OF STUDENTS FROM GROUPS HISTORICALLY EXCLUDED FROM PHYSICS. THE NEW PROGRAM, SUPER-TECH SHIP, WILL HAVE THE FOLLOWING ELEMENTS (1) RECRUITMENT BY SYRACUSE PHYSICS FACULTY VISITING ALL SYRACUSE CITY SCHOOL DISTRICT SCIENCE CLASSROOMS, (2) AN APPLICATION PROCESS FOCUSED ON STUDENT PERSISTENCE, (3) INITIAL BOOTCAMPS TO ORIENT AND READY THE STUDENTS FOR ALL THE INTERNSHIPS IN RESEARCH LABS, (4) A LONGER-TERM RESEARCH EXPERIENCE IN A LAB, AND (5) AN END OF THE PROGRAM POSTER SESSION AND CELEBRATION WITH FRIENDS, FAMILY, AND TEACHERS. THE SUPER-TECH SHIP WILL INCLUDE BRINGING BACK PRIOR PARTICIPANTS TO SERVE AS NEAR-PEER MENTORS TO THE HIGH SCHOOL PARTICIPANTS. NEW PARTNERS FROM INDUSTRY AND NATIONAL LABS ARE BEING INCORPORATED TO GIVE MORE ROLE-MODELS WITH WHOM STUDENT PARTICIPANTS WILL NETWORK. EXTENSIVE COHORT BUILDING, ASSERTIVE MENTORING, AND BELONGING INTERVENTIONS WILL BE IMPLEMENTED THROUGH THE SUPER-TECH SHIP. IN LABS, PARTICIPANTS WILL WORK IN PAIRS TO HAVE A LOCAL PEER MENTOR. STUDENT PAIRS WILL MIX DURING ORIENTATION BOOTCAMPS TO EXPAND THEIR PEER NETWORK. NEAR-PEER MENTORS (UNDERGRADS AND PRIOR COHORT PARTICIPANTS) WILL BE INVOLVED IN RESEARCH WITH THE PARTICIPANTS. WEEKLY FUN ACTIVITIES WILL EXPLORE THE CAMPUS TO ACCLIMATE HIGH SCHOOL PARTICIPANTS. WITHIN THE SYRACUSE PHYSICS DEPARTMENT, A DEDICATED SPACE WILL BE CREATED FOR THESE STUDENTS FOR THE DURATION OF THE 6-WEEK PROGRAM. A SCSD TEACHER WILL CHECK IN WITH STUDENTS WEEKLY AND GIVE FEEDBACK TO THE DEPARTMENT ON REAL-TIME CHANGES. STUDENTS WILL ALSO HAVE WEEKLY SCIENCE SEMINARS AND LUNCH WITH SPEAKERS FROM THE FACULTY, INDUSTRY, AND A LOCAL AIR FORCE RESEARCH LAB. FINALLY, THE PROGRAM WILL HAVE A DEDICATED GRADUATE STUDENT ADMINISTRATIVE STAFF MEMBER FROM THE SAME NEIGHBORHOODS AS THE HIGH SCHOOL PARTICIPANTS TO SERVE AS A RESOURCE AND MENTOR. SYSTEMIC BARRIERS TO INTERNSHIPS EXIST FOR SYRACUSE CITY STUDENTS. TO RECRUIT STUDENTS AND ELIMINATE BARRIERS, THE INTERNSHIP PROVIDES EACH STUDENT WITH A SIGNIFICANT STIPEND, DAILY TRANSPORTATION TO AND FRONT THE UNIVERSITY, AND DAILY BREAKFAST AND LUNCH AT A DINING HALL ON CAMPUS. THESE MECHANISMS ARE NEEDED TO (1) ENTICE STUDENTS TO THIS OPPORTUNITY, (2) MAKE IT WORTH THEIR WHILE FINANCIALLY COMPARED TO OTHER JOBS IN THE SUMMER, (3) REDUCE BARRIERS OF TRANSPORTATION IN THE CITY, AND (4) INCREASE FOOD SECURITY OF THE STUDENTS WHILE IN OUR PROGRAM. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

QUALITATIVE DATA REPOSITORY 2016-2018

NEUTRINO RESEARCH AT SYRACUSE UNIVERSITY

TOWARD DETECTION OF GRAVITATIONAL WAVES WITH ENHANCED LIGO AND ADVANCED LIGO

PROJECT IMPRESS (INTERDISCIPLINARY MASTER’S PREPARATION OF URBAN AND RURAL EDUCATORS IN SPECIAL EDUCATION AND SCHOOL COUNSELING)

NEURAL MECHANISMS UNDERLYING BEHAVIORAL VARIABILITY IN UNI- AND MULTI-SENSORY CONTEXTS - PROJECT SUMMARY/ABSTRACT DECISIONS AN ANIMAL MAKES ON THE BASIS OF MULTI-SENSORY INPUT ARE CRUCIAL TO ITS SURVIVAL. HOW DO NEURAL CIRCUITS RESOLVE CONFLICTS TO CHOOSE AMONG AVAILABLE BEHAVIORS WHILE RECEIVING MULTIPLE AND VARIABLE INPUTS? THE NAVIGATIONAL BEHAVIORS OF LARVAL DROSOPHILA FORM A PROMISING MODEL IN WHICH TO RELATE NEURAL ACTIVITY AND BEHAVIOR. POWERFUL GENETIC REAGENTS ARE AVAILABLE IN DROSOPHILA TO TARGET NEARLY ARBITRARY SUBSETS OF 10,000 NEURONS THAT MAKE UP THE LARVA’S CENTRAL NERVOUS SYSTEM (~3, 000 IN THE BRAIN HEMISPHERES), AND AN EM RECONSTRUCTION OF THIS NETWORK IS ALMOST COMPLETE. THE LARVA’S CUTICLE IS SEMI-TRANSPARENT, AND THE ENTIRETY OF ITS REPRESENTATIVE INSECT BRAIN IS OPTICALLY ACCESSIBLE FOR IN VIVO INTERROGATION OR MANIPULATION. EVEN A SIMPLE ORGANISM LIKE THE LARVA RESPONDS VARIABLY TO SEEMINGLY IDENTICAL STIMULUS PRESENTATIONS. WHAT IS THE ORIGIN OF THIS VARIABILITY? THIS QUESTION CAN BE PHRASED USING THE LANGUAGE OF INFORMATION THEORY. IF I REPEATEDLY PRESENT THE SAME STIMULUS AND OBSERVE DIFFERENT BEHAVIORS, THEN THE STIMULUS DOES NOT CONTAIN FULL INFORMATION ABOUT THE BEHAVIOR. BUT DIRECTLY MEASURING THE ACTIVITIES OF THE MOTOR NEURONS THAT CONTROL MOVEMENT WOULD ALWAYS ALLOW ONE TO PREDICT THE BEHAVIOR; THESE NEURONS HAVE MORE INFORMATIONABOUT THE BEHAVIOR THAN IS PRESENT IN THE STIMULUS, AND THIS EXTRA INFORMATION ORIGINATES SOMEWHERE IN THE NERVOUS SYSTEM. THE TASK OF FINDING WHERE AND HOW VARIABILITY ORIGINATES IN LARVA’S TRACTABLE NERVOUS SYSTEM REQUIRES AN INTEGRATED APPROACH IN DESCRIBING A BEHAVIOR, IDENTIFYING WHICH NEURONS ARE INVOLVED, RESOLVING HOW CIRCUIT ACTIVITY ENCODES THOSE BEHAVIORS, AND DISCOVERING THE MECHANISMS GENERATING THESE NEURAL TRANSFORMATIONS. TO ACHIEVE THIS TASK, I HAVE DEVELOPED TWO TECHNIQUES OF NEURAL CIRCUIT INTERROGATION: AN OPTOGENETIC REVERSE-CORRELATION BEHAVIORAL ASSAY THAT CAN DETERMINE THE ROLE OF ANY TARGETED NEURON IN DECISION MAKING, AND A FIRST EVER TWO-PHOTON TRACKING MICROSCOPE THAT CAN RECORD THE NEURAL ACTIVITY AS LARVA FREELY NAVIGATES ITS SENSORY ENVIRONMENTS. IN THIS PROJECT, I WILL DECODE THE CIRCUITRY UNDERLYING THE LARVA’S NAVIGATIONAL RESPONSES TO UNI- AND MULTI-SENSORY INPUT. IN MANY NEUROLOGICAL AND PSYCHIATRIC DISORDERS, SUCH AS SCHIZOPHRENIA, AUTISM SPECTRUM DISORDER, DYSLEXIA, AND ADHD, THE PROCESSING OF MULTISENSORY INFORMATION IS COMPROMISED, PERHAPS FROM ABNORMALITIES IN THE NEURAL CIRCUITS THAT ARE RESPONSIBLE FOR INTEGRATING SENSORY INFORMATION. THIS RESEARCH WILL ADVANCE OUR UNDERSTANDING OF THE NEURAL BASIS OF MULTISENSORY DECISION-MAKING, WHICH WILL ALLOW US TO BETTER UNDERSTAND THE DEFECTS IN INFORMATION PROCESSING THAT OCCUR DURING DISEASE.

NITROGEN FIXATION AND CARBON STORAGE BY HERBIVORE-GRASS-MUTUALIST INTERACTION WEBS IN THE SERENGETI

SYRACUSE UNIVERSITY INDUSTRIAL ASSESSMENT CENTER

THIS IS THE FOURTH (AND FINAL) YEAR FOR THE BOOTS TO BUSINESS GRANT PROGRAM TO PROVIDE ENTREPRENEURSHIP TRAINING, CURRICULUM UPDATES, AND PROGRAM MANAGEMENT SUPPORT SERVICES FOR GLOBAL DELIVERY OF THE B2B TWO-DAY CLASSROOM AND B2B FOLLOW-ON TRAINING.

SHAPE MEMORY POLYMER FOAMS FOR HEMORRHAGE CONTROL IN TRAUMATIC WOUNDS - PROJECT SUMMARY/ABSTRACT UNCONTROLLED HEMORRHAGE IS THE PRIMARY CAUSE OF TRAUMA-RELATED DEATH, AND APPROXIMATELY HALF OF HEMORRHAGE DEATHS OCCUR BEFORE THE PATIENT REACHES THE HOSPITAL. CURRENT TECHNIQUES FOR HEMORRHAGE CONTROL ARE INSUFFICIENT FOR A LARGE NUMBER OF WOUNDS AND DO NOT ADEQUATELY ADDRESS NON-COMPRESSIBLE HEMORRHAGES. THUS, THERE IS A CRITICAL NEED FOR IMPROVED HEMOSTATIC DRESSING MATERIALS THAT ARE INEXPENSIVE, EASY TO APPLY, EFFECTIVE, AND SAFE TO USE OVER PROLONGED TIME FRAMES. IN THE ABSENCE OF SUCH TREATMENT OPTIONS, TRAGIC DEATHS FROM UNCONTROLLED BLEEDING WILL CONTINUE. THE LONG-TERM GOAL OF THE PROPOSED WORK IS TO PROVIDE AN ACCESSIBLE OPTION FOR HEMORRHAGE CONTROL THAT CAN BE USED WITH MINIMAL TRAINING IN REMOTE SITUATIONS. THE OVERALL OBJECTIVES IN THIS APPLICATION ARE TO CHARACTERIZE EFFICACY OF A PROMISING BIOMATERIAL PLATFORM, SHAPE MEMORY POLYMER (SMP) FOAMS, IN CLINICALLY-RELEVANT HEMORRHAGE MODELS AND TO DEVELOP EASY-TO-USE STORAGE AND DELIVERY DEVICES. IN PRELIMINARY WORK IN A PORCINE GRADE V LIVER INJURY, SMP FOAM TREATMENT PROVIDED FASTER HEMOSTASIS, REDUCED TOTAL BLOOD LOSS, AND IMPROVED SURVIVAL RELATIVE TO TREATMENT WITH CLINICAL CONTROLS. THE RATIONALE FOR THE PROPOSED WORK IS THAT FUTURE CLINICAL TRANSLATION EFFORTS WILL BE ENABLED BY AN IMPROVED UNDERSTANDING OF HOW FOAM PROPERTIES AFFECT HEMORRHAGE CONTROL AND EXPANDED PRE-CLINICAL CHARACTERIZATION OF THIS PROMISING PLATFORM. TO ACHIEVE THESE OBJECTIVES, THE FOLLOWING SPECIFIC AIMS WILL BE PURSUED: SPECIFIC AIM 1: EVALUATE EFFECTS OF SMP FOAM ARCHITECTURES ON HEMORRHAGE CONTROL IN IN VITRO WOUND MODELS, AND DESIGN STORAGE AND DELIVERY DEVICES FOR NON-COMPRESSIBLE TORSO WOUNDS AND COMPRESSIBLE EXTREMITY WOUNDS. SPECIFIC AIM 2: CHARACTERIZE SMP FOAM EFFICACY IN VIVO IN A NON-COMPRESSIBLE GRADE V LIVER INJURY. SPECIFIC AIM 3: CHARACTERIZE SMP FOAM APPLICATION, EFFICACY, REMOVAL, AND SAFETY IN VIVO IN A COMPRESSIBLE FEMORAL ARTERY INJURY. AT THE COMPLETION OF THESE STUDIES, THE EXPECTATION IS TO HAVE CLINICALLY-RELEVANT SMP FOAM- BASED HEMOSTATIC DEVICE DESIGNS FOR USE IN COMPRESSIBLE AND NON-COMPRESSIBLE TRAUMATIC WOUNDS. THE PRIMARY POSITIVE IMPACT OF THESE STUDIES WILL BE A HEMOSTATIC DRESSING THAT IS EASY- TO-USE AND EFFECTIVE IN A RANGE OF HEMORRHAGIC WOUND TYPES.

COLLABORATIVE RESEARCH: BEE: ECOLOGICAL AND COEVOLUTIONARY FEEDBACKS IN MULTI-MUTUALIST COMMUNITIES -MUTUALISMS ARE BENEFICIAL INTERACTIONS BETWEEN SPECIES THAT ARE IMPORTANT IN NATURAL COMMUNITIES AND AGRICULTURAL SYSTEMS BECAUSE THEY GENERATE CRITICAL RESOURCES AND SERVICES NEEDED FOR SPECIES TO PERSIST. FOR EXAMPLE, POLLINATION MUTUALISMS ARE ESSENTIAL FOR FRUIT PRODUCTION IN MANY CROP PLANTS, AND POLLINATORS ARE DEPENDENT ON THE FOOD THEY OBTAIN FROM THOSE FLOWERS. MUTUALISMS, IN GENERAL, USUALLY INVOLVE MANY SPECIES INTERACTING WITH ONE ANOTHER IN COMPLEX COMMUNITIES, YET WE KNOW RELATIVELY LITTLE ABOUT THE FACTORS THAT GOVERN THEM. THUS, AS GLOBAL CHANGE CONTINUES TO ALTER ECOSYSTEMS ON EARTH, THERE IS A STRONG NEED TO UNDERSTAND HOW SPECIES THAT FORM MUTUALISMS CHANGE IN RESPONSE TO THE ENVIRONMENT AND TO ONE ANOTHER. FOR INSTANCE, THE PRESENCE OF COMPETITIVE SPECIES THAT USE THE RESOURCES MADE BY MUTUALISTS COULD ALTER THE WAY IN WHICH THE MUTUALISTS CHANGE IN RESPONSE TO ONE ANOTHER. THIS RESEARCH WILL EXAMINE HOW LARGE GROUPS OF MUTUALIST SPECIES CHANGE IN RESPONSE TO EACH OTHER ACROSS DIFFERENT ENVIRONMENTS AND HOW OTHER COMPETITIVE SPECIES CAN INFLUENCE THESE CHANGES. THE PROJECT USES AN EXPERIMENTAL SYSTEM BASED ON BREWER?S YEAST TO UNDERSTAND HOW SPECIES CHANGE IN RESPONSE TO ONE ANOTHER IN COMPLEX MUTUALISMS INVOLVING MANY SPECIES. IN ADDITION TO TESTING HOW MUTUALISMS CHANGE IN SPECIES RICH COMMUNITIES, AN ENGAGING VIDEO GAME WILL BE DEVELOPED TO TEACH HIGH SCHOOL STUDENTS ABOUT THE ECONOMIC VALUE OF MUTUALISMS AND HOW THEY CHANGE OVER TIME. THE PROJECT WILL USE A LABORATORY-BASED NUTRITIONAL MUTUALISM COMPOSED OF STRAINS OF BUDDING YEAST THAT EXCHANGE NUTRIENT RESOURCES WITH EACH OTHER, THUS SIMULATING MUTUALISTIC SPECIES. USING THIS SYSTEM, THE RESEARCHERS WILL MANIPULATE THE NUMBER OF MUTUALIST SPECIES IN THE COMMUNITIES AND THE AMOUNT OF ENVIRONMENTALLY-AVAILABLE RESOURCES TO ADDRESS THE FOLLOWING GOALS: 1) EVALUATE HOW RECIPROCAL TRAIT CHANGES (I.E., COEVOLUTION) VARY IN COMPLEX MUTUALIST COMMUNITIES WITH AND WITHOUT TRADED RESOURCES ADDITIONALLY AVAILABLE FROM THE LOCAL ENVIRONMENT, 2) TEST HOW COEVOLUTION INFLUENCES THE ESTABLISHMENT OF NEW MUTUALISTS IN SPECIES-RICH MUTUALIST COMMUNITIES, 3) TEST HOW A COMPETITIVE SPECIES ALTERS THE COEVOLUTION OF MUTUALISTS AND HOW COEVOLUTION IMPACTS MUTUALISM RESISTANCE TO THESE COMPETITORS. RESULTS FROM THE PROPOSED STUDY WILL IDENTIFY THE ECOLOGICAL CONTEXTS THAT AFFECT COEVOLUTION IN MUTUALISMS, THE EVOLUTIONARY CONTEXTS THAT ALLOWS ESTABLISHMENT OF NONRESIDENT SPECIES, AND HOW COEVOLUTION IMPACTS ECOLOGICAL PERSISTENCE OF MUTUALISTS AND COMPETITIVE SPECIES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

A QUANTITATIVE ANALYSIS OF PHENOTYPE IN A MULTICELLULAR PROKARYOTE

B2B-2022 SYRACUSE UNIVERSITY IVMF_ OCONUS

CENTER ON DISABILITY EMPLOYMENT POLICY (DEP) - THE BURTON BLATT INSTITUTE (BBI) AT SYRACUSE UNIVERSITY, IN PARTNERSHIP WITH CORNELL, HARVARD, AND RUTGERS UNIVERSITIES, MATHEMATICA, AND KNOWLEDGE DISSEMINATION PARTNERS WILL INFORM CURRENT AND FUTURE EMPLOYMENT POLICY AND PROGRAMS FOR PEOPLE WITH DISABILITIES. OVER THE NEXT FIVE YEARS, THE GOAL OF DEP RRTC IS TO IMPLEMENT A COMPREHENSIVE RESEARCH AGENDA THAT ESTABLISHES A FORWARD-LOOKING DISABILITY EMPLOYMENT POLICY FRAMEWORK TO REALIZE THE POTENTIAL OF PEOPLE WITH DISABILITIES ACROSS THE FULL ARC OF THE EMPLOYMENT CYCLE. THE CENTER’S OBJECTIVE IS TO CONDUCT A COHESIVE SET OF RANDOMIZED CONTROLLED TRIALS, QUASI-EXPERIMENTS, AND QUALITATIVE STUDIES TO EXAMINE FEDERAL, REGIONAL, STATE, AND INDUSTRY POLICIES AND PROGRAMS. THIS RESEARCH WILL IDENTIFY AND ENHANCE OUTCOMES RELATED TO EMPLOYMENT ENTRY, WAGE AND INCOME LEVELS, JOB RETENTION AND QUALITY, AND CAREER PATHS TO ECONOMIC STABILITY, IN CONSIDERATION OF THE CURRENT LABOR MARKET FRONTIER AND NEW TECHNOLOGIES SUCH AS AI. ANTICIPATED OUTCOMES FOR THE TARGET POPULATIONS INCLUDE STATE-OF-THE-ART EVIDENCE FOR: POLICYMAKERS TO ENHANCE EMPLOYMENT POLICY DEVELOPMENT; VR AND WORKFORCE DEVELOPMENT PROFESSIONALS TO SUPPORT JOB SEEKERS; BUSINESSES, HR PROFESSIONALS, AND EMPLOYMENT PROVIDERS TO IMPROVE JOB RETENTION, QUALITY, AND CAREER PATHS; RESEARCHERS, SCHOLARS, PRACTITIONERS, AND STUDENTS TO ADVANCE CURRENT AND NEXT-GENERATION POLICY RESEARCH THAT PROMOTES EMPLOYMENT AND ECONOMIC SELF-SUFFICIENCY FOR WORKING-AGE ADULTS WITH DISABILITIES. THE DEP RRTC WILL PROVIDE COMPREHENSIVE AND ACCESSIBLE KNOWLEDGE TRANSLATION CUSTOMIZED FOR SPECIFIC AND ACROSS TARGET AUDIENCES. PRODUCTS WILL INCLUDE PEER-REVIEWED ARTICLES, BOOKS, PRESENTATIONS, POLICY BRIEFS, NEWSLETTERS, AND ONLINE AND IN-PERSON TECHNICAL ASSISTANCE FOR POLICYMAKERS, PEOPLE WITH DISABILITIES, BUSINESS LEADERS, AND VR PROFESSIONALS, AS WELL AS WEBINARS AND VIRTUAL ACADEMIES FOR COLLECTIVE LEARNING AND ACTION.

CONTINUING PROFESSIONAL EDUCATION PROGRAM IN FORENSIC ANTHROPOLOGY BY SYRACUSE UNIVERSITY

SYRACUSE UNIVERSITY BUILDING, TRAINING AND ASSESSMENT CENTER (BTAC)

MOVING TOWARD GRAVITATIONAL WAVE DETECTION IN ADVANCED LIGO

SYRACUSE UNIVERSITY NOYCE SCHOLARS PROGRAM FOR SCIENCE AND MATHEMATICS TEACHERS

TAS::57 3600::TAS "FUNDAMENTALS TURBULENCE MECHANISMS IN MULTI-STREAM FLOWS: A COMPREHENSIVE JOINT EXPERIMENTAL, THEORETICAL AND COMPUTATIONAL STUDY"

QUALITATIVE DATA REPOSITORY 2015-2016

ARCHITECTURE AND FUNCTION OF CONDENSATES FORMED BY UBIQUITIN-BINDING SHUTTLE PROTEINS AND PROTEIN QUALITY CONTROL COMPONENTS - PROJECT SUMMARY/ABSTRACT: EFFICIENT AND EFFECTIVE PROTEIN QUALITY CONTROL (PQC) IS ESSENTIAL TO PROPER CELL FUNCTION. DESPITE EXTENSIVE RESEARCH, MECHANISMS UNDERLYING PQC REMAIN INCOMPLETELY UNDERSTOOD. CONSEQUENTLY, DEVELOPMENT OF NEW THERAPIES TO TREAT CONDITIONS WITH DYSREGULATED PQC SUCH AS PROTEINOPATHIES AND NEURODEGENERATIVE DISORDERS IS IMPEDED. THIS MIRA RESEARCH PROGRAM TARGETS THE UBIQUITIN (UB)-MEDIATED PQC PATHWAYS, AND SPECIFICALLY UB-CONTAINING BIOMOLECULAR CONDENSATES. THESE CONDENSATES ARE MEMBRANELESS ASSEMBLIES COMPRISING UB-BINDING SHUTTLE PROTEINS (E.G., UBQLNS, RAD23S) THAT PREFERENTIALLY CONDENSE WITH SPECIFIC TYPES OF POLYUB CHAINS AND PQC COMPONENTS; THE CONDENSATES ARE INVOLVED IN A WIDE RANGE OF PHYSIOLOGICAL PROCESSES INCLUDING STRESS RESPONSE, PROTEASOMAL DEGRADATION, AUTOPHAGY, AND IMMUNE SYSTEM ACTIVATION. MY LAB’S WORK IS GROUNDED IN THE HYPOTHESIS THAT DYSREGULATION OF THESE CONDENSATES LEADS TO UB-CONTAINING INCLUSIONS CHARACTERISTIC OF PROTEINOPATHIES AND NEURODEGENERATIVE DISORDERS, AND SPECIFICALLY AMYOTROPHIC LATERAL SCLEROSIS (ALS) AND FRONTOTEMPORAL DEMENTIA. WE RECENTLY DETERMINED THAT ALS-LINKED UBQLN2 FORMS STRESS-INDUCED BIOMOLECULAR CONDENSATES IN CELLS AND THAT THE FULL-LENGTH UBQLNS (1/2/4) ALL UNDERGO PHASE SEPARATION IN VITRO TO FORM CONDENSATES UNDER PHYSIOLOGICAL CONDITIONS. IMPORTANT TO THE PREMISE GUIDING OUR PROJECTS IS THE OBSERVATION THAT INTERACTIONS WITH POLYUB CHAINS (IN LENGTH- AND LINKAGE- DEPENDENT MANNERS) TUNE CONDITIONS FOR CONDENSATE ASSEMBLY AND DISASSEMBLY. WE PREDICT THAT OTHER PQC COMPONENTS FURTHER TUNE THE ASSEMBLY/DISASSEMBLY AND STRUCTURE OF THESE CONDENSATES. IN THIS FIVE-YEAR MIRA PROGRAM, MY LAB WILL USE MOLECULAR BIOPHYSICS AND CELL BIOLOGY-BASED APPROACHES TO ACHIEVE A MECHANISTIC UNDERSTANDING OF HOW UB-BINDING SHUTTLE PROTEINS (UBQLNS, RAD23S, DDIS) REGULATE FUNCTION OF BIOMOLECULAR CONDENSATES IN STRESS RESPONSE AND PQC. OUR PRELIMINARY DATA FROM RECONSTITUTION EXPERIMENTS SUGGEST THAT CONDENSATES DRIVE DISTINCT PQC OUTCOMES (E.G., PROTECTING SUBSTRATES FROM DEGRADATION OR DRIVING SUBSTRATE DEGRADATION). WE SURMISE THAT THESE DIFFERENT OUTCOMES STEM FROM DIFFERENT CONDITIONS DRIVING CONDENSATE FORMATION AND/OR THE VARIED MOLECULAR ARCHITECTURES OF CONDENSATES COMPOSED OF DIFFERING COMPOSITIONS OF SHUTTLE PROTEINS AND UBIQUITINATED SUBSTRATES. OUR PROJECTS WILL DETERMINE (1) THE PHYSIOLOGICAL FUNCTIONS OF UBQLN CONDENSATE FORMATION IN CELLS UNDER A MYRIAD OF CELL STRESS CONDITIONS, (2) THE MOLECULAR RULES BY WHICH POLYUB CHAINS MODULATE CONDENSATION OF SHUTTLE PROTEINS AND PQC COMPONENTS (E.G., FULL PROTEASOMES, DEUBIQUITINASES, LIGASES), AND (3) THE EMERGENT FUNCTIONS OF SHUTTLE PROTEIN PQC CONDENSATES IN REGULATING SUBSTRATE DEGRADATION, PROTECTION FROM DEGRADATION, AND SUBSTRATE UBIQUITINATION/DEUBIQUITINATION. THE RESULTS FROM THESE PROJECTS WILL UNCOVER THE ROLE OF CONDENSATES IN MEDIATING PQC UNDER PHYSIOLOGICAL AND STRESS CONDITIONS.

BRIEF ACCEPTANCE AND COMMITMENT THERAPY FOR HIV-INFECTED AT-RISK DRINKERS

IDENTIFICATION AND CHARACTERIZATION OF IN-THE-MOMENT COGNITIVE ANTECEDENTS TO ALCOHOL USE AMONG DRINKERS WITH PTSD - ABSTRACT POSTTRAUMATIC STRESS DISORDER (PTSD) CO-OCCURS FREQUENTLY WITH HAZARDOUS ALCOHOL OUTCOMES, PRESENTING CONSIDERABLE PUBLIC HEALTH BURDENS AND CHALLENGING TRADITIONAL TREATMENT APPROACHES. ALTHOUGH ACCESSIBLE INTERVENTIONS ABLE TO ADAPT TO INDIVIDUALS’ FLUCTUATING INTERNAL RISKS WITHIN THEIR NATURAL ENVIRONMENTS ARE EMERGING, THESE JUST-IN-TIME ADAPTIVE INTERVENTIONS HAVE LARGELY NOT YET CONSIDERED THE ROLE OF TRAUMA SEQUALAE IN ALCOHOL USE. TO DO SO, RESEARCH NEEDS TO IDENTIFY THE ACUTE RISKS FOR DRINKING OPERATING IN-THE-MOMENT AS INDIVIDUALS EXPERIENCE PTSD SYMPTOMS IN THEIR DAILY LIVES. THERE IS A CRITICAL NEED TO DEFINE AND OPERATIONALIZE ACUTE COGNITIVE PROCESSES UNDERLYING PTSD-RELATED DRINKING (AIM 1), EXAMINE VARIABILITY IN SUCH COGNITIONS AMID PTSD SYMPTOMS IN REAL-WORLD SETTINGS (AIM 2), AND ESTABLISH WHICH OF THESE ACUTE COGNITIONS ARE LINKED TO ACTUAL DRINKING EVENTS AND MEDIATE PTSD-RELATED DRINKING (AIM 3). DURING THE K99 PHASE, AIM 1 COMPRISES A FINE-GRAINED QUALITATIVE EXAMINATION INTO ACUTE RISK COGNITIONS AMONG FREQUENT DRINKERS WITH PTSD, UTILIZING FOCUS GROUPS TO IDENTIFY KEY ACUTE COGNITIONS AND COGNITIVE INTERVIEWING APPROACHES TO OPERATIONALIZE MEASURES OF SUCH COGNITIONS. AIM 2 FIELD-TESTS THESE COGNITIVE ASSESSMENTS BY EXAMINING WHETHER THEY VARY ACROSS DRINKERS’ DAILY LIVES AND ARE ACTIVE AMID PTSD SYMPTOMS WITHIN A 14-DAY ECOLOGICAL MOMENTARY ASSESSMENT (EMA) STUDY. DURING THE R00 PHASE, AIM 3 CONSIDERABLY EXTENDS SUCH WORK TO TEST WHETHER THESE ACUTE COGNITIONS ARE LINKED TO ACTUAL DRINKING EVENTS AS WELL AS WHETHER THEY ARE MECHANISMS OF PTSD-RELATED DRINKING ACROSS ANOTHER 14-DAY EMA. COLLECTIVELY, THIS MIXED METHODS INVESTIGATION WILL IDENTIFY PROXIMAL COGNITIVE MECHANISMS OF PTSD-RELATED DRINKING THAT CAN BE TARGETED IN FUTURE JUST-IN-TIME INTERVENTIONS. AS A K99/R00 NIH PATHWAY TO INDEPENDENCE AWARD, THESE RESEARCH EFFORTS WOULD SUPPORT THE EMERGENCE OF A DEDICATED EARLY CAREER RESEARCHER (DR. ZASO) WITH UNIQUE EXPERTISE IN ACUTE COGNITIVE TRAUMA-RELATED DRINKING PROCESSES. THIS K99/R00 ALSO WOULD AFFORD DR. ZASO INSTRUMENTAL DEVELOPMENT IN ACUTE PTSD-RELATED DRINKING PROCESSES, MOMENTARY ASSESSMENT OF AFFECTIVE ALCOHOL COGNITIONS, AND THE METHODOLOGICAL/STATISTICAL TECHNIQUES NECESSARY TO CHARACTERIZE MOMENTARY, REAL-WORLD DRINKING PROCESSES. THE MENTORSHIP TEAM OFFERS EXPERTISE IN THE INTERSECTION OF TRAUMA AND ALCOHOL USE (DR. JENNIFER READ), WITH COLLABORATION SUPPORT ON DAILY PROCESSES IN PTSD-RELATED DRINKING (DR. TRACY SIMPSON), ACUTE ACTIVATION OF ALCOHOL COGNITIONS (DR. ROBERT DVORAK), OPTIMIZATION OF MOBILE ALCOHOL ASSESSMENT AND INTERVENTION (DR. TAMMY CHUNG), AND STATISTICAL MODELING OF MULTILEVEL ALCOHOL ETIOLOGIES (DR. CRAIG COLDER). DR. ZASO’S CAREER DEVELOPMENT WILL OCCUR WITHIN THE DEPARTMENT OF PSYCHOLOGY AND CLINICAL AND RESEARCH INSTITUTE ON ADDICTIONS AT THE UNIVERSITY AT BUFFALO, WHICH COMPRISE A RICH INTELLECTUAL ENVIRONMENT WITH A NETWORK OF PRODUCTIVE ADDICTIONS RESEARCHERS. OVERALL, THIS K99/R00 WILL PROPEL DR. ZASO’S EMERGENCE AS AN INDEPENDENT TRAUMA-RELATED ALCOHOL RESEARCHER WITH THE SKILLS NECESSARY TO MAINTAIN A CLINICALLY IMPACTFUL RESEARCH PROGRAM AIMED AT CURTAILING ALCOHOL HARMS.

SPREADING SEEDS: LARGE-SCALE DISSEMINATION OF HANDS-ON LABS FOR SECURITY EDUCATION

CAREER: DETECTOR TECHNOLOGY AND SCIENCE EDUCATION IN THE ERA OF GRAVITATIONAL WAVE ASTROPHYSICS

NEUTRINO PHYSICS AT SYRACUSE UNIVERSITY

DEVELOPMENT OF A FEDERAL CYBER FORCE AT SYRACUSE UNIVERSITY - SCHOLARSHIP TRACK

MRI: ACQUISITION OF AN ELECTRON MICROPROBE AT SYRACUSE UNIVERSITY: A CENTRAL NEW YORK REGIONAL USER FACILITY

A PROSPECTIVE MODEL OF MEDICARE COST TRAJECTORIES

DISABILITY AND REHABILITATION RESEARCH PROJECTS

MEETING THE GRADUATE 10K+ CHALLENGE: ENHANCING THE CLIMATE FOR PERSISTENCE AND SUCCESS IN ENGINEERING (ECLIPSE)

CAREER: DECIPHERING MOLECULAR MECHANISMS UNDERLYING LIQUID-LIQUID PHASE SEPARATION OF UBIQUILIN PROTEINS

ALCOHOL USE AND HIGH RISK BEHAVIOR AMONG HIV-POSITIVE MEN

COLLABORATIVE RESEARCH: CHARACTERIZING QUATERNARY FAULT BEHAVIOR AND SURFACE PROCESSES OF AN ACTIVE RIFT: THE LAKE MALAWI (NYASA) RIFT, EAST AFRICA

CAREER: CHEMICAL TOOLS FOR BIO-ORTHOGONAL NEUROMODULATION -WITH THE SUPPORT OF THE CHEMISTRY OF LIFE PROCESSES PROGRAM IN THE DIVISION OF CHEMISTRY, RACHEL STEINHARDT OF SYRACUSE UNIVERSITY WILL DEVELOP CHEMICAL TOOLS TO UNDERSTAND HOW INDIVIDUAL CELLS COMMUNICATE TO CREATE BRAIN ACTIVITY. DECODING THIS COMMUNICATION PROMISES TO ENABLE NEW INSIGHTS INTO PHENOMENA SUCH AS LEARNING, MOOD, AND SLEEP. THE RESEARCH FOCUSES ON THE CHEMICAL SYNTHESIS OF PROBES AND OPTIMIZATION OF THEIR CHEMICAL AND BIOCHEMICAL PROPERTIES. THEY WILL THEN BE TESTED IN ASSAYS THAT DETERMINE THE ABILITY OF THE PROBE TO INTERACT WITH A TARGET IN A SPATIALLY- OR TEMPORALLY DEFINED MANNER, WHICH CAN THEN BE CORRELATED TO A BIOCHEMICAL OR NEURONAL EVENT. THE INTERDISCIPLINARY NATURE OF THIS PROGRAM WILL ALLOW GRADUATE STUDENTS AND UNDERGRADUATES TO GAIN EXPERTISE IN MODERN RESEARCH TECHNIQUES. THE PROJECT ALSO INTEGRATES AN OUTREACH PROGRAM TO TEACH CHEMISTRY IN AN AFTER SCHOOL PROGRAM AT MIDDLE SCHOOLS SYRACUSE CITY SCHOOL DISTRICT. ONE OF THE MOST PERPLEXING CHALLENGES IN NEUROSCIENCE IS HOW TO EXPLAIN THE BRAIN?S ABILITY TO LEARN AND CHANGE ITSELF, CREATING SEEMINGLY INFINITE BEHAVIORS AND STATES (SLEEPING, WAKEFULNESS, ATTENTION) WHILE USING A FIXED ANATOMICAL CONNECTIVITY. TO ANSWER THESE QUESTIONS, IT IS NECESSARY TO DEFINE THE LINK BETWEEN MEMBRANE-BOUND RECEPTOR BINDING EVENTS AND THE ENSEMBLE ACTIVITY OF NEURONS. UNFORTUNATELY, THERE IS A PAUCITY OF CHEMICAL TOOLS TO ADEQUATELY PROBE NEURAL ACTIVITY VIA STIMULATION OF THE NATIVE RECEPTORS. THE STEINHARDT LAB WILL ADDRESS THIS NEED BY SYNTHESIZING PROBES FOR SPATIALLY DEFINED NATIVE RECEPTOR CONTROL AND TEMPORALLY DEFINED NEUROCHEMICAL SIGNALING,THAT WILL THEN BE USED IN BIOCHEMICAL AND PRIMARY CELL-BASED ASSAYS. THESE PROBES ARE SMALL MOLECULE METHODS FOR RESEARCHERS TO CONTROL NATIVE CHEMICAL SYNAPSES WITH LIGHT. SUCH PROBES ARE EXPECTED TO FACILITATE BOTTOM-UP EXPERIMENTS (I.E., CELL TO NEURAL NETWORK) TO DETERMINE THE MECHANISTIC RELATIONSHIP BETWEEN LEARNING AND NEURAL STATE FLEXIBILITY AND MODULATION OF NATIVE DOPAMINE AND SEROTONIN RECEPTOR SUBTYPES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

PFI: WIRELESS GRID INNOVATION TESTBED

THIS PROJECT SEEKS TO APPLY A FULLY INTEGRATED COUPLED HYDROLOGICAL AND BIOGEOCHEMICAL MODEL (PNET-BGC) TO EVALUATE THE EFFECTS OF CLIMATE CHANGE AT

CAREER: NON-EQUILIBRIUM PHYSICS OF BIOLOGICAL INTERFACES

MECHANISTIC UNDERSTANDING OF SILVER SORBENT AGING PROCESSES IN OFF-GAS TREATMENT

TAS::57 3600:: TAS "DYNAMIC DATA DRIVEN INFORMATION FUSION FOR SITUATIONAL AWARENESS, DATED 17 JUN 2014" (THE GRANTEE'S TECHNICAL PROPOSAL)

MRI: DEVELOPMENT OF A HIGH-THROUGHPUT COMPUTING CLUSTER FOR GRAVITATIONAL-WAVE DATA ANALYSIS AND HIGH-ENERGY PHYSICS

SOCS: SOCIALLY INTELLIGENT COMPUTING FOR CODING OF QUALITATIVE DATA

COLLABORATIVE RESEARCH: TECTONIC AND MAGMATIC PROCESSES DURING EARLY-STAGE RIFTING: AN INTEGRATED STUDY OF NORTHERN LAKE MALAWI, AFRICA

IUCRC PHASE I: SYRACUSE UNIVERSITY: CENTER FOR SOLID-STATE ELECTRIC POWER STORAGE (CEPS)

A MULTILEVEL HIV PREVENTION STRATEGY FOR HIGH-RISK YOUTH

ACTIVE FLOW CONTROL OF A COMPLEX 3D SUPERSONIC MULT-STREAM NOZZLE FLOW

THE MOLECULAR LIFE HISTORY OF MALE GAMETES

CAREER: ULTRATHIN SHEETS ON CURVED LIQUID SURFACES: STRESS FOCUSING AND INTERFACIAL ASSEMBLY

COLLABORATIVE RESEARCH: FW-HTF-RM: AUGMENTATION FOR TOMORROW: EXPANDING THE FUTURE CAPACITIES OF INDEPENDENT WORKERS

ADAPTIVE MODELS AND FUSION ALGORITHMS FOR INFORMATION EXPLOITATION