Scope Inc

SEISMOLOGICAL FACILITIES FOR THE ADVANCEMENT OF GEOSCIENCE AND EARTHSCOPE

COLLABORATIVE RESEARCH: EARTHSCOPE FACILITY OPERATION AND MAINTENANCE (FY2008-FY2013) (USARRAY)

ENABLING DISCOVERIES IN MULTISCALE EARTH SYSTEM DYNAMICS: SEISMOLOGICAL FACILITY FOR THE ADVANCEMENT OF GEOSCIENCE (SAGE) - EAR SCOPE

ENABLING DISCOVERIES IN MULTISCALE EARTH SYSTEM DYNAMICS: SEISMOLOGICAL FACILITY FOR THE ADVANCEMENT OF GEOSCIENCE (SAGE) -THE IRIS (INCORPORATED RESEARCH INSTITUTIONS FOR SEISMOLOGY) CONSORTIUM WILL DEVELOP, OPERATE, AND MAINTAIN A DISTRIBUTED, MULTI-USER FACILITY ENTITLED SEISMOLOGICAL FACILITIES FOR THE ADVANCEMENT OF GEOSCIENCE (SAGE). EXPERT PROFESSIONAL STAFF, WITH GUIDANCE PROVIDED BY THE SCIENTIFIC COMMUNITY, WILL MANAGE AND OPERATE A SET OF FOUNDATIONAL CAPABILITIES THAT ARE ESSENTIAL FOR CURRENT RESEARCH SUPPORT, AS WELL AS FRONTIER ACTIVITIES THAT WILL ENABLE FUTURE RESEARCH. THE FACILITY WILL PROMOTE ADVANCES IN OUR UNDERSTANDING OF EARTH STRUCTURE AND DYNAMICS, EARTHQUAKES AND VOLCANIC ERUPTIONS, AND INTERACTIONS BETWEEN THE SOLID EARTH, HYDROSPHERE, AND ATMOSPHERE THROUGH MANAGEMENT AND OPERATION OF: 1) GLOBAL AND REGIONAL CONTINUOUSLY OPERATING SEISMIC NETWORKS, INCLUDING THE GLOBAL SEISMOGRAPHIC NETWORK; 2) PORTABLE GEOPHYSICAL INSTRUMENTATION FOR USE IN PRINCIPAL INVESTIGATOR DRIVEN AND COMMUNITY EXPERIMENTS; 3) DATA MANAGEMENT SYSTEMS FOR THE COLLECTION, QUALITY ASSURANCE, CURATION, MANAGEMENT, AND DISTRIBUTION OF OPEN ACCESS DATA AND DATA PRODUCTS; AND 4) EDUCATION, WORKFORCE DEVELOPMENT, AND PUBLIC OUTREACH PROGRAMS DESIGNED TO BE INCLUSIVE AND ENHANCE PARTICIPATION OF TRADITIONALLY UNDERREPRESENTED GROUPS IN THE GEOSCIENCES. THE SEISMOLOGICAL FACILITIES PROVIDED THROUGH THE SAGE CONTRIBUTE TO ISSUES OF NATIONAL/GLOBAL STRATEGIC IMPORTANCE, INCLUDING GEOHAZARD ASSESSMENT AND DISASTER RESILIENCE; ENVIRONMENTAL MANAGEMENT AND ECONOMIC DEVELOPMENT; NATIONAL SECURITY; AND STEM (SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS) EDUCATION AND WORKFORCE DEVELOPMENT. DATA AND DATA PRODUCTS FROM SAGE WILL BE USED BY STATE AND FEDERAL AGENCIES INCLUDING THE UNITED STATES GEOLOGICAL SURVEY, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, NATIONAL AERONAUTICS AND SPACE ADMINISTRATION, DEPARTMENT OF ENERGY, AND DEPARTMENT OF DEFENSE, FOR MISSION AGENCY ACTIVITIES, INCLUDING EARTHQUAKE MONITORING AND CHARACTERIZATION, TSUNAMI WARNING, WEATHER FORECASTING, WATER AND ENVIRONMENTAL MANAGEMENT, AND NUCLEAR TEST MONITORING. SAGE PROGRAMS WILL ALSO SUPPORT INQUIRY-BASED SCIENCE EDUCATION, ENHANCING STUDENTS' ABILITIES TO ENGAGE DIRECTLY WITH SCIENCE AND ENGINEERING PRINCIPLES AND PRACTICE, AND ENABLING THEM TO PURSUE STEM CAREERS IN ACADEMIA, INDUSTRY, BUSINESS, AND GOVERNMENT. THE SAGE OUTREACH ACTIVITIES PROMOTE PUBLIC ENGAGEMENT AND SCIENCE LITERACY. THE SAGE FACILITY PROVIDES INSTRUMENTATION SERVICES; DATA SERVICES; AND EDUCATION, WORKFORCE DEVELOPMENT, AND COMMUNITY ENGAGEMENT ACTIVITIES IN SUPPORT OF SEISMOLOGY. RESEARCHERS USE SAGE TO GAIN VALUABLE INSIGHTS INTO FUNDAMENTAL EARTH PROCESSES, AND SAGE ALSO PROVIDES KEY DATA FOR NATIONAL SECURITY NEEDS, INCLUDING MONITORING EFFORTS OF CLANDESTINE NUCLEAR TESTS. THE SCIENTIFIC PRIORITIES OF THE NEW FACILITY WOULD ENABLE ADVANCES IN THE FOLLOWING AREAS: (1) GLOBAL EARTH STRUCTURE AND DYNAMICS: THE FACILITY WOULD ENHANCE OUR ABILITY TO RESOLVE THE THREE-DIMENSIONAL STRUCTURE OF THE EARTH'S INTERIOR AND ENABLE INVESTIGATORS TO STUDY PROCESSES THAT DRIVE PLATE TECTONICS AND NATURAL HAZARDS SUCH AS EARTHQUAKES, TSUNAMIS, AND VOLCANIC ERUPTIONS. (2) FAULT ZONES AND THE EARTHQUAKE CYCLE: OVER THE LAST DECADE, SCIENTISTS HAVE DISCOVERED A BROAD ARRAY OF FAULT ZONE SLIP BEHAVIORS THAT SPAN A WIDE VARIETY OF TEMPORAL AND SPATIAL SCALES. THE SAGE FACILITY WILL ENABLE A VARIETY OF SEISMIC AND ELECTROMAGNETIC MEASUREMENTS TO ELUCIDATE HOW THESE DIFFERENT TYPES OF BEHAVIORS START AND STOP, VARY ALONG FAULT ZONES, AND INTERACT WITH ONE ANOTHER. (3) MAGMAS AND VOLATILES IN THE CRUST AND MANTLE: GEOPHYSICAL INSTRUMENTATION IS CRITICAL FOR UNDERSTANDING VOLCANIC SYSTEMS AND MINIMIZING RISKS ASSOCIATED WITH VOLCANIC HAZARDS. THE CAPABILITIES PROVIDED BY SAGE WILL ENABLE RESEARCHERS TO STUDY MELT PRODUCTION, MONITOR ITS TRANSPORT THROUGH THE CRUST, AND MAP OUT THE PLUMBING SYSTEMS OF VOLCANOES. (4) HYDROSPHERE, CRYOSPHERE, AND ATMOSPHERE: AN AREA OF INCREASING COMMUNITY INTEREST IS UTILIZING GEOPHYSICAL MEASUREMENTS TO STUDY PROCESSES AT THE EARTH'S SURFACE. THE SAGE FACILITY WILL PROVIDE OPPORTUNITIES TO STUDY PROCESSES IN THE NEAR-SURFACE, SUCH AS HYDROLOGY, CRYOSPHERIC PROCESSES, AND GLACIER DYNAMICS. (5) EDUCATION, PUBLIC OUTREACH, AND WORKFORCE DEVELOPMENT: SAGE WILL DEVELOP A VARIETY OF EDUCATIONAL RESOURCES AND ENABLE HUNDREDS OF UNDERGRADUATE RESEARCH OPPORTUNITIES. A MAJOR FOCUS OF THE SAGE ACTIVITIES WILL BE ON BROADENING PARTICIPATION OF UNDERREPRESENTED STUDENTS THROUGH IRIS' NEW URBAN GEOSYSTEMS FOCUS. ADDITIONALLY, THE FACILITY WILL DEVELOP ANIMATIONS, SIMULATIONS, AND OTHER VISUALIZATIONS OF EARTH PROCESSES TO HELP INSTRUCTORS AT ALL LEVEL TEACH ABOUT EARTH SCIENCE. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

IRIS: CORNERSTONE FACILITIES FOR SEISMOLOGY AND EARTH SCIENCES

ENABLING DISCOVERIES IN MULTISCALE EARTH SYSTEM DYNAMICS: GEODETIC FACILITY FOR THE ADVANCEMENT OF GEOSCIENCE (GAGE) - EAR SCOPE -UNAVCO WILL DEVELOP, OPERATE, AND MAINTAIN A DISTRIBUTED, MULTI-USER GEODETIC FACILITY FOR THE ADVANCEMENT OF GEOSCIENCE (GAGE). GEODESY CHARACTERIZES THE EARTH'S TIME VARYING SHAPE, ORIENTATION IN SPACE, MASS DISTRIBUTION, AND GRAVITY FIELD. IT HAS REVOLUTIONIZED THE GEOSCIENCES, BY MEASURING EARTH CHANGES WITH UNPRECEDENTED SPATIAL AND TEMPORAL RESOLUTION. THE GAGE FACILITY EMPLOYS EXPERT PROFESSIONAL STAFF, WITH GUIDANCE PROVIDED BY THE SCIENTIFIC COMMUNITY, TO MANAGE AND OPERATE A SET OF FOUNDATIONAL GEODETIC CAPABILITIES THAT ARE ESSENTIAL FOR CURRENT RESEARCH SUPPORT, AS WELL AS FRONTIER GEODETIC ACTIVITIES THAT WILL ENABLE FUTURE RESEARCH. THE FACILITY WILL PROMOTE ADVANCES IN OUR UNDERSTANDING OF CONTINENTAL DEFORMATION; TECTONIC PLATE BOUNDARY PROCESSES; THE PROCESSES THAT DRIVE EARTHQUAKES, VOLCANIC ERUPTIONS AND LANDSLIDE HAZARDS; CONTINENTAL WATER STORAGE, ATMOSPHERIC, ICE SHEET AND GLACIER DYNAMICS; AND INTERACTIONS AMONG THESE COMPONENTS OF THE EARTH SYSTEM. THE GEODETIC CAPABILITIES PROVIDED THROUGH THE GAGE FACILITY CONTRIBUTE TO ISSUES OF NATIONAL/GLOBAL STRATEGIC IMPORTANCE, INCLUDING GEOHAZARD ASSESSMENT AND DISASTER RESILIENCE; ENVIRONMENTAL MANAGEMENT AND ECONOMIC DEVELOPMENT; AND STEM (SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS) EDUCATION AND WORKFORCE DEVELOPMENT. DATA PRODUCTS FROM GAGE WILL BE USED BY FEDERAL AGENCIES INCLUDING THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION, THE UNITED STATES GEOLOGICAL SURVEY AND THE NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, FOR MISSIONS INCLUDING SPACECRAFT POSITIONING, SATELLITE ORBIT, AND TIMING CORRECTIONS; EARTHQUAKE, TSUNAMI, AND VOLCANO EARLY WARNING; WEATHER FORECASTING; WATER RESOURCES; AND ENVIRONMENTAL MANAGEMENT. STATE DEPARTMENTS OF TRANSPORTATION WILL USE GAGE DATA TO HELP SUPPORT TRAFFIC MONITORING AND CONTROL AND INCREASINGLY GAGE DATA WILL SUPPORT COMMERCIAL SECTOR POSITIONING NEEDS INCLUDING FOR AGRICULTURE, CONSTRUCTION AND SURVEYING, TRANSPORTATION (INCLUDING AIR, RAIL, AND MARITIME), MINING AND RESOURCE EXPLORATION, AND FLEET VEHICLE TRACKING. THE GAGE FACILITY WILL MANAGE AND OPERATE: 1) GLOBAL AND REGIONAL CONTINUOUSLY OPERATING GLOBAL NAVIGATIONAL SATELLITE SYSTEMS (GNSS) AND COMPLEMENTARY GEODETIC TECHNOLOGY NETWORKS; 2) PORTABLE GEOPHYSICAL INSTRUMENTATION FOR USE IN PRINCIPAL INVESTIGATOR DRIVEN AND COMMUNITY EXPERIMENTS; 3) GEODETIC INSTRUMENTATION TESTING AND SUPPORT SERVICE; 3) DATA MANAGEMENT SYSTEMS FOR THE COLLECTION, QUALITY ASSURANCE, CURATION, MANAGEMENT, AND DISTRIBUTION OF OPEN ACCESS DATA AND DATA PRODUCTS; AND 4) EDUCATION, WORKFORCE DEVELOPMENT, AND PUBLIC OUTREACH PROGRAMS THAT FOSTER THE DEVELOPMENT OF THE NEXT GENERATION GEOSCIENCES WORKFORCE, ARE DESIGNED TO BE INCLUSIVE AND ENHANCE PARTICIPATION OF TRADITIONALLY UNDERREPRESENTED GROUPS IN THE GEOSCIENCES, AND ENGAGE THE PUBLIC BY HIGHLIGHTING ADVANCES IN GEOPHYSICAL SCIENCES AND THEIR SOCIETAL RELEVANCE. INNOVATIVE AND TRANSFORMATIVE RESEARCH THAT WILL BENEFIT FROM GAGE EXAMINES BOTH THE DYNAMICS OF INDIVIDUAL PROCESSES AND THE NONLINEAR INTERACTIONS WITHIN AND AMONG LARGER EARTH SYSTEMS. THE STUDY OF ACTIVE PROCESSES FROM GEOCENTER MOTION TO THE STUDIES OF THE LITHOSPHERE, CRYOSPHERE, HYDROSPHERE, AND ATMOSPHERE REQUIRES UNDERSTANDING OF THE COUPLING AND FEEDBACKS ACROSS A RANGE OF LENGTH AND TIME SCALES, AND BETWEEN THE SOLID EARTH AND ITS FLUID ENVELOPES, IN BOTH PHYSICAL AND BIOLOGICAL ENVIRONMENTS. UNDER NSF, AND NASA PARTNER AGENCY SUPPORT FOR GAGE, UNAVCO WILL INTEGRATE AND FEDERATE A SET OF CURRENTLY OPERATED BUT AT PRESENT INDEPENDENTLY MANAGED GNSS STATIONS TO FORM THE NETWORK OF THE AMERICAS (NOTA). UNAVCO WILL MODERNIZE NOTA STATIONS WITH STATE-OF-THE-ART, MULTI-SENSOR, MULTI-GNSS, RECEIVERS WITH REAL-TIME STREAMING DATA AND ANALYSIS. THESE ENHANCEMENTS WILL ENABLE HIGHER PRECISION POSITIONING THAN CURRENTLY POSSIBLE AND NEW APPLICATION OF GNSS DATA THAT CAN BE USED FOR GEOHAZARDS WARNING SYSTEMS, STUDY OF OCEAN AND ATMOSPHERE DYNAMICAL BEHAVIOR, AND OBSERVATION OF KEY ENVIRONMENTAL PARAMETERS SUCH AS WATER STORAGE, SOIL MOISTURE, AND SEA AND LAKE-LEVEL CHANGES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

A COMMUNITY-BASED OBSIP MANAGEMENT OFFICE

FACILITATING NEW DISCOVERIES IN SEISMOLOGY AND EXPLORING THE EARTH: THE NEXT DECADE

RESEARCH INFRASTRUCTURE: NATIONAL GEOPHYSICAL FACILITY (NGF): ADVANCING EARTH SCIENCE CAPABILITIES THROUGH INNOVATION - EAR SCOPE -GEODESY IS THE SCIENCE OF MEASURING AND UNDERSTANDING THE EARTH?S SHAPE AND ITS ORIENTATION IN SPACE, AS WELL AS THE CHANGES OF THESE PROPERTIES WITH TIME. SEISMOLOGY IS THE STUDY OF ELASTIC WAVES IN THE EARTH, THE SOURCES THAT GENERATE SUCH WAVES, AND THE EARTH STRUCTURE THROUGH WHICH THEY TRAVEL. COMBINED, GEODESY AND SEISMOLOGY PLAY CRITICAL ROLES IN UNDERSTANDING THE DEFORMATION OF THE EARTH?S SURFACE AND ADDRESSING QUESTIONS ABOUT EARTH?S STRUCTURE, EVOLUTION, AND DYNAMICS, INCLUDING PROBLEMS OF SIGNIFICANT SOCIETAL RELEVANCE, SUCH AS NATURAL HAZARDS, RESOURCES, AND NATIONAL SECURITY. ?THE NATIONAL GEOPHYSICAL FACILITY: ADVANCING EARTH SCIENCE CAPABILITIES THROUGH INNOVATION? AWARD SUPPORTS NATIONAL GEOPHYSICAL RESOURCES FOR DISCOVERIES ACROSS EARTH SCIENCE AND ADVANCING THE SCIENCE OF GEODESY AND SEISMOLOGY. THE FACILITY WILL PROVIDE SCIENTIFIC INSTRUMENTATION, DATA CAPABILITIES, AND WORKFORCE DEVELOPMENT SPANNING MANY DISCIPLINES AND APPLICATIONS, FROM EARTHQUAKE PHYSICS TO SPACE WEATHER. BY SHARING SENSORS, DATA, AND ANALYSIS TOOLS ACROSS THOUSANDS OF INVESTIGATIONS, THE NATIONAL FACILITY MAXIMIZES BOTH OPERATIONAL EFFICIENCY AND SCIENTIFIC ADVANCEMENT. THE CAPABILITIES OF THE FACILITY ARE ALSO BEING USED BEYOND THE RESEARCH DOMAIN TO MONITOR GEOPHYSICAL AND NUCLEAR THREAT DETECTION, TO ADVANCE FORECASTING AND PREPAREDNESS, AND TO PROVIDE ECONOMIC DEVELOPMENT THROUGH TECHNOLOGY TRANSFER. THE NATIONAL GEOPHYSICAL FACILITY (NGF) WILL OPERATE SEVERAL FUNCTIONAL COMPONENTS, INCLUDING A LARGE POOL OF ADVANCED GEOPHYSICAL SENSORS OF MORE THAN 40 DIFFERENT TYPES, OPERATION OF PERSISTENT GLOBAL AND REGIONAL SENSOR NETWORKS DELIVERING LOW-LATENCY DATA, A CLOUD-NATIVE DATA REPOSITORY WITH MULTIPLE POINTS OF ACCESS AND DATA ANALYSIS SERVICES AND PRODUCTS, AND A RANGE OF OUTREACH, TRAINING, AND EDUCATIONAL RESOURCES. THESE COMPONENTS SUPPORT RESEARCH AND TECHNICAL DEVELOPMENT IN EARTH SCIENCE FROM THE INNER CORE TO THE OUTERMOST ATMOSPHERE. SOME NOVEL RESEARCH DIRECTIONS AND APPLICATIONS ENABLED BY FACILITY ADVANCEMENT INCLUDE ARTIFICIAL INTELLIGENCE AND MACHINE LEARNING APPROACHES TO HAZARDS AND THEIR CASCADING IMPACTS, OCEAN-BOTTOM CAPABILITIES IN GEODESY, INTEGRATION OF NEAR-SURFACE OBSERVATIONS WITH SOLID-EARTH DATA, AND NOVEL PLATFORMS FOR INDEPENDENT AND ASYNCHRONOUS TECHNICAL TRAINING. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

CONVERGENCE: WHEN ART AND STEM MEET

USAID NON-FORMAL EDUCATION PROGRAM

COLLABORATIVE RESEARCH: EARTHSCOPE-ACQUISITION, CONSTRUCTION, AND FACILITY MANAGEMENT (USARRAY)

COLLABORATIVE RESEARCH: EARTHSCOPE-FACILITY OPERATIONS AND MAINTENANCE (USARRAY)

UNITED STATES GEOLOGICAL SURVEY SUPPLEMENTAL FUNDING FOR THE GEODETIC FACILITY FOR THE ADVANCEMENT OF GEOSCIENCE (GAGE) -UNAVCO WILL DEVELOP, OPERATE, AND MAINTAIN A DISTRIBUTED, MULTI-USER GEODETIC FACILITY FOR THE ADVANCEMENT OF GEOSCIENCE (GAGE). GEODESY CHARACTERIZES THE EARTH'S TIME VARYING SHAPE, ORIENTATION IN SPACE, MASS DISTRIBUTION, AND GRAVITY FIELD. IT HAS REVOLUTIONIZED THE GEOSCIENCES, BY MEASURING EARTH CHANGES WITH UNPRECEDENTED SPATIAL AND TEMPORAL RESOLUTION. THE GAGE FACILITY EMPLOYS EXPERT PROFESSIONAL STAFF, WITH GUIDANCE PROVIDED BY THE SCIENTIFIC COMMUNITY, TO MANAGE AND OPERATE A SET OF FOUNDATIONAL GEODETIC CAPABILITIES THAT ARE ESSENTIAL FOR CURRENT RESEARCH SUPPORT, AS WELL AS FRONTIER GEODETIC ACTIVITIES THAT WILL ENABLE FUTURE RESEARCH. THE FACILITY WILL PROMOTE ADVANCES IN OUR UNDERSTANDING OF CONTINENTAL DEFORMATION; TECTONIC PLATE BOUNDARY PROCESSES; THE PROCESSES THAT DRIVE EARTHQUAKES, VOLCANIC ERUPTIONS AND LANDSLIDE HAZARDS; CONTINENTAL WATER STORAGE, ATMOSPHERIC, ICE SHEET AND GLACIER DYNAMICS; AND INTERACTIONS AMONG THESE COMPONENTS OF THE EARTH SYSTEM. THE GEODETIC CAPABILITIES PROVIDED THROUGH THE GAGE FACILITY CONTRIBUTE TO ISSUES OF NATIONAL/GLOBAL STRATEGIC IMPORTANCE, INCLUDING GEOHAZARD ASSESSMENT AND DISASTER RESILIENCE; ENVIRONMENTAL MANAGEMENT AND ECONOMIC DEVELOPMENT; AND STEM (SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS) EDUCATION AND WORKFORCE DEVELOPMENT. DATA PRODUCTS FROM GAGE WILL BE USED BY FEDERAL AGENCIES INCLUDING THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION, THE UNITED STATES GEOLOGICAL SURVEY AND THE NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, FOR MISSIONS INCLUDING SPACECRAFT POSITIONING, SATELLITE ORBIT, AND TIMING CORRECTIONS; EARTHQUAKE, TSUNAMI, AND VOLCANO EARLY WARNING; WEATHER FORECASTING; WATER RESOURCES; AND ENVIRONMENTAL MANAGEMENT. STATE DEPARTMENTS OF TRANSPORTATION WILL USE GAGE DATA TO HELP SUPPORT TRAFFIC MONITORING AND CONTROL AND INCREASINGLY GAGE DATA WILL SUPPORT COMMERCIAL SECTOR POSITIONING NEEDS INCLUDING FOR AGRICULTURE, CONSTRUCTION AND SURVEYING, TRANSPORTATION (INCLUDING AIR, RAIL, AND MARITIME), MINING AND RESOURCE EXPLORATION, AND FLEET VEHICLE TRACKING. THE GAGE FACILITY WILL MANAGE AND OPERATE: 1) GLOBAL AND REGIONAL CONTINUOUSLY OPERATING GLOBAL NAVIGATIONAL SATELLITE SYSTEMS (GNSS) AND COMPLEMENTARY GEODETIC TECHNOLOGY NETWORKS; 2) PORTABLE GEOPHYSICAL INSTRUMENTATION FOR USE IN PRINCIPAL INVESTIGATOR DRIVEN AND COMMUNITY EXPERIMENTS; 3) GEODETIC INSTRUMENTATION TESTING AND SUPPORT SERVICE; 3) DATA MANAGEMENT SYSTEMS FOR THE COLLECTION, QUALITY ASSURANCE, CURATION, MANAGEMENT, AND DISTRIBUTION OF OPEN ACCESS DATA AND DATA PRODUCTS; AND 4) EDUCATION, WORKFORCE DEVELOPMENT, AND PUBLIC OUTREACH PROGRAMS THAT FOSTER THE DEVELOPMENT OF THE NEXT GENERATION GEOSCIENCES WORKFORCE, ARE DESIGNED TO BE INCLUSIVE AND ENHANCE PARTICIPATION OF TRADITIONALLY UNDERREPRESENTED GROUPS IN THE GEOSCIENCES, AND ENGAGE THE PUBLIC BY HIGHLIGHTING ADVANCES IN GEOPHYSICAL SCIENCES AND THEIR SOCIETAL RELEVANCE. INNOVATIVE AND TRANSFORMATIVE RESEARCH THAT WILL BENEFIT FROM GAGE EXAMINES BOTH THE DYNAMICS OF INDIVIDUAL PROCESSES AND THE NONLINEAR INTERACTIONS WITHIN AND AMONG LARGER EARTH SYSTEMS. THE STUDY OF ACTIVE PROCESSES FROM GEOCENTER MOTION TO THE STUDIES OF THE LITHOSPHERE, CRYOSPHERE, HYDROSPHERE, AND ATMOSPHERE REQUIRES UNDERSTANDING OF THE COUPLING AND FEEDBACKS ACROSS A RANGE OF LENGTH AND TIME SCALES, AND BETWEEN THE SOLID EARTH AND ITS FLUID ENVELOPES, IN BOTH PHYSICAL AND BIOLOGICAL ENVIRONMENTS. UNDER NSF, AND NASA PARTNER AGENCY SUPPORT FOR GAGE, UNAVCO WILL INTEGRATE AND FEDERATE A SET OF CURRENTLY OPERATED BUT AT PRESENT INDEPENDENTLY MANAGED GNSS STATIONS TO FORM THE NETWORK OF THE AMERICAS (NOTA). UNAVCO WILL MODERNIZE NOTA STATIONS WITH STATE-OF-THE-ART, MULTI-SENSOR, MULTI-GNSS, RECEIVERS WITH REAL-TIME STREAMING DATA AND ANALYSIS. THESE ENHANCEMENTS WILL ENABLE HIGHER PRECISION POSITIONING THAN CURRENTLY POSSIBLE AND NEW APPLICATION OF GNSS DATA THAT CAN BE USED FOR GEOHAZARDS WARNING SYSTEMS, STUDY OF OCEAN AND ATMOSPHERE DYNAMICAL BEHAVIOR, AND OBSERVATION OF KEY ENVIRONMENTAL PARAMETERS SUCH AS WATER STORAGE, SOIL MOISTURE, AND SEA AND LAKE-LEVEL CHANGES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

ENABLING DISCOVERIES IN MULTISCALE EARTH SYSTEM DYNAMICS: SEISMOLOGICAL FACILITY FOR THE ADVANCEMENT OF GEOSCIENCE (SAGE) - OPP SCOPE

CLINICAL VALIDATION OF A/LCI FOR DETECTING PRE-CANCEROUS LESIONS IN THE ESOPHAGUS

ENABLING DISCOVERIES IN MULTISCALE EARTH SYSTEM DYNAMICS: GEODETIC FACILITY FOR THE ADVANCEMENT OF GEOSCIENCE (GAGE) - OPP SCOPE -UNAVCO WILL DEVELOP, OPERATE, AND MAINTAIN A DISTRIBUTED, MULTI-USER GEODETIC FACILITY FOR THE ADVANCEMENT OF GEOSCIENCE (GAGE). GEODESY CHARACTERIZES THE EARTH'S TIME VARYING SHAPE, ORIENTATION IN SPACE, MASS DISTRIBUTION, AND GRAVITY FIELD. IT HAS REVOLUTIONIZED THE GEOSCIENCES, BY MEASURING EARTH CHANGES WITH UNPRECEDENTED SPATIAL AND TEMPORAL RESOLUTION. THE GAGE FACILITY EMPLOYS EXPERT PROFESSIONAL STAFF, WITH GUIDANCE PROVIDED BY THE SCIENTIFIC COMMUNITY, TO MANAGE AND OPERATE A SET OF FOUNDATIONAL GEODETIC CAPABILITIES THAT ARE ESSENTIAL FOR CURRENT RESEARCH SUPPORT, AS WELL AS FRONTIER GEODETIC ACTIVITIES THAT WILL ENABLE FUTURE RESEARCH. THE FACILITY WILL PROMOTE ADVANCES IN OUR UNDERSTANDING OF CONTINENTAL DEFORMATION; TECTONIC PLATE BOUNDARY PROCESSES; THE PROCESSES THAT DRIVE EARTHQUAKES, VOLCANIC ERUPTIONS AND LANDSLIDE HAZARDS; CONTINENTAL WATER STORAGE, ATMOSPHERIC, ICE SHEET AND GLACIER DYNAMICS; AND INTERACTIONS AMONG THESE COMPONENTS OF THE EARTH SYSTEM. THE GEODETIC CAPABILITIES PROVIDED THROUGH THE GAGE FACILITY CONTRIBUTE TO ISSUES OF NATIONAL/GLOBAL STRATEGIC IMPORTANCE, INCLUDING GEOHAZARD ASSESSMENT AND DISASTER RESILIENCE; ENVIRONMENTAL MANAGEMENT AND ECONOMIC DEVELOPMENT; AND STEM (SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS) EDUCATION AND WORKFORCE DEVELOPMENT. DATA PRODUCTS FROM GAGE WILL BE USED BY FEDERAL AGENCIES INCLUDING THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION, THE UNITED STATES GEOLOGICAL SURVEY AND THE NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, FOR MISSIONS INCLUDING SPACECRAFT POSITIONING, SATELLITE ORBIT, AND TIMING CORRECTIONS; EARTHQUAKE, TSUNAMI, AND VOLCANO EARLY WARNING; WEATHER FORECASTING; WATER RESOURCES; AND ENVIRONMENTAL MANAGEMENT. STATE DEPARTMENTS OF TRANSPORTATION WILL USE GAGE DATA TO HELP SUPPORT TRAFFIC MONITORING AND CONTROL AND INCREASINGLY GAGE DATA WILL SUPPORT COMMERCIAL SECTOR POSITIONING NEEDS INCLUDING FOR AGRICULTURE, CONSTRUCTION AND SURVEYING, TRANSPORTATION (INCLUDING AIR, RAIL, AND MARITIME), MINING AND RESOURCE EXPLORATION, AND FLEET VEHICLE TRACKING. THE GAGE FACILITY WILL MANAGE AND OPERATE: 1) GLOBAL AND REGIONAL CONTINUOUSLY OPERATING GLOBAL NAVIGATIONAL SATELLITE SYSTEMS (GNSS) AND COMPLEMENTARY GEODETIC TECHNOLOGY NETWORKS; 2) PORTABLE GEOPHYSICAL INSTRUMENTATION FOR USE IN PRINCIPAL INVESTIGATOR DRIVEN AND COMMUNITY EXPERIMENTS; 3) GEODETIC INSTRUMENTATION TESTING AND SUPPORT SERVICE; 3) DATA MANAGEMENT SYSTEMS FOR THE COLLECTION, QUALITY ASSURANCE, CURATION, MANAGEMENT, AND DISTRIBUTION OF OPEN ACCESS DATA AND DATA PRODUCTS; AND 4) EDUCATION, WORKFORCE DEVELOPMENT, AND PUBLIC OUTREACH PROGRAMS THAT FOSTER THE DEVELOPMENT OF THE NEXT GENERATION GEOSCIENCES WORKFORCE, ARE DESIGNED TO BE INCLUSIVE AND ENHANCE PARTICIPATION OF TRADITIONALLY UNDERREPRESENTED GROUPS IN THE GEOSCIENCES, AND ENGAGE THE PUBLIC BY HIGHLIGHTING ADVANCES IN GEOPHYSICAL SCIENCES AND THEIR SOCIETAL RELEVANCE. INNOVATIVE AND TRANSFORMATIVE RESEARCH THAT WILL BENEFIT FROM GAGE EXAMINES BOTH THE DYNAMICS OF INDIVIDUAL PROCESSES AND THE NONLINEAR INTERACTIONS WITHIN AND AMONG LARGER EARTH SYSTEMS. THE STUDY OF ACTIVE PROCESSES FROM GEOCENTER MOTION TO THE STUDIES OF THE LITHOSPHERE, CRYOSPHERE, HYDROSPHERE, AND ATMOSPHERE REQUIRES UNDERSTANDING OF THE COUPLING AND FEEDBACKS ACROSS A RANGE OF LENGTH AND TIME SCALES, AND BETWEEN THE SOLID EARTH AND ITS FLUID ENVELOPES, IN BOTH PHYSICAL AND BIOLOGICAL ENVIRONMENTS. UNDER NSF, AND NASA PARTNER AGENCY SUPPORT FOR GAGE, UNAVCO WILL INTEGRATE AND FEDERATE A SET OF CURRENTLY OPERATED BUT AT PRESENT INDEPENDENTLY MANAGED GNSS STATIONS TO FORM THE NETWORK OF THE AMERICAS (NOTA). UNAVCO WILL MODERNIZE NOTA STATIONS WITH STATE-OF-THE-ART, MULTI-SENSOR, MULTI-GNSS, RECEIVERS WITH REAL-TIME STREAMING DATA AND ANALYSIS. THESE ENHANCEMENTS WILL ENABLE HIGHER PRECISION POSITIONING THAN CURRENTLY POSSIBLE AND NEW APPLICATION OF GNSS DATA THAT CAN BE USED FOR GEOHAZARDS WARNING SYSTEMS, STUDY OF OCEAN AND ATMOSPHERE DYNAMICAL BEHAVIOR, AND OBSERVATION OF KEY ENVIRONMENTAL PARAMETERS SUCH AS WATER STORAGE, SOIL MOISTURE, AND SEA AND LAKE-LEVEL CHANGES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

AMBIENT LIGHT ACTIVATABLE OPSIN BASED THERAPY FOR AGE-RELATED MACULAR DEGENERATION

ENABLING DISCOVERIES IN MULTISCALE EARTH SYSTEM DYNAMICS: GEODETIC FACILITY FOR THE ADVANCEMENT OF GEOSCIENCE (GAGE)-NASA SCOPE -UNAVCO WILL DEVELOP, OPERATE, AND MAINTAIN A DISTRIBUTED, MULTI-USER GEODETIC FACILITY FOR THE ADVANCEMENT OF GEOSCIENCE (GAGE). GEODESY CHARACTERIZES THE EARTH'S TIME VARYING SHAPE, ORIENTATION IN SPACE, MASS DISTRIBUTION, AND GRAVITY FIELD. IT HAS REVOLUTIONIZED THE GEOSCIENCES, BY MEASURING EARTH CHANGES WITH UNPRECEDENTED SPATIAL AND TEMPORAL RESOLUTION. THE GAGE FACILITY EMPLOYS EXPERT PROFESSIONAL STAFF, WITH GUIDANCE PROVIDED BY THE SCIENTIFIC COMMUNITY, TO MANAGE AND OPERATE A SET OF FOUNDATIONAL GEODETIC CAPABILITIES THAT ARE ESSENTIAL FOR CURRENT RESEARCH SUPPORT, AS WELL AS FRONTIER GEODETIC ACTIVITIES THAT WILL ENABLE FUTURE RESEARCH. THE FACILITY WILL PROMOTE ADVANCES IN OUR UNDERSTANDING OF CONTINENTAL DEFORMATION; TECTONIC PLATE BOUNDARY PROCESSES; THE PROCESSES THAT DRIVE EARTHQUAKES, VOLCANIC ERUPTIONS AND LANDSLIDE HAZARDS; CONTINENTAL WATER STORAGE, ATMOSPHERIC, ICE SHEET AND GLACIER DYNAMICS; AND INTERACTIONS AMONG THESE COMPONENTS OF THE EARTH SYSTEM. THE GEODETIC CAPABILITIES PROVIDED THROUGH THE GAGE FACILITY CONTRIBUTE TO ISSUES OF NATIONAL/GLOBAL STRATEGIC IMPORTANCE, INCLUDING GEOHAZARD ASSESSMENT AND DISASTER RESILIENCE; ENVIRONMENTAL MANAGEMENT AND ECONOMIC DEVELOPMENT; AND STEM (SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS) EDUCATION AND WORKFORCE DEVELOPMENT. DATA PRODUCTS FROM GAGE WILL BE USED BY FEDERAL AGENCIES INCLUDING THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION, THE UNITED STATES GEOLOGICAL SURVEY AND THE NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, FOR MISSIONS INCLUDING SPACECRAFT POSITIONING, SATELLITE ORBIT, AND TIMING CORRECTIONS; EARTHQUAKE, TSUNAMI, AND VOLCANO EARLY WARNING; WEATHER FORECASTING; WATER RESOURCES; AND ENVIRONMENTAL MANAGEMENT. STATE DEPARTMENTS OF TRANSPORTATION WILL USE GAGE DATA TO HELP SUPPORT TRAFFIC MONITORING AND CONTROL AND INCREASINGLY GAGE DATA WILL SUPPORT COMMERCIAL SECTOR POSITIONING NEEDS INCLUDING FOR AGRICULTURE, CONSTRUCTION AND SURVEYING, TRANSPORTATION (INCLUDING AIR, RAIL, AND MARITIME), MINING AND RESOURCE EXPLORATION, AND FLEET VEHICLE TRACKING. THE GAGE FACILITY WILL MANAGE AND OPERATE: 1) GLOBAL AND REGIONAL CONTINUOUSLY OPERATING GLOBAL NAVIGATIONAL SATELLITE SYSTEMS (GNSS) AND COMPLEMENTARY GEODETIC TECHNOLOGY NETWORKS; 2) PORTABLE GEOPHYSICAL INSTRUMENTATION FOR USE IN PRINCIPAL INVESTIGATOR DRIVEN AND COMMUNITY EXPERIMENTS; 3) GEODETIC INSTRUMENTATION TESTING AND SUPPORT SERVICE; 3) DATA MANAGEMENT SYSTEMS FOR THE COLLECTION, QUALITY ASSURANCE, CURATION, MANAGEMENT, AND DISTRIBUTION OF OPEN ACCESS DATA AND DATA PRODUCTS; AND 4) EDUCATION, WORKFORCE DEVELOPMENT, AND PUBLIC OUTREACH PROGRAMS THAT FOSTER THE DEVELOPMENT OF THE NEXT GENERATION GEOSCIENCES WORKFORCE, ARE DESIGNED TO BE INCLUSIVE AND ENHANCE PARTICIPATION OF TRADITIONALLY UNDERREPRESENTED GROUPS IN THE GEOSCIENCES, AND ENGAGE THE PUBLIC BY HIGHLIGHTING ADVANCES IN GEOPHYSICAL SCIENCES AND THEIR SOCIETAL RELEVANCE. INNOVATIVE AND TRANSFORMATIVE RESEARCH THAT WILL BENEFIT FROM GAGE EXAMINES BOTH THE DYNAMICS OF INDIVIDUAL PROCESSES AND THE NONLINEAR INTERACTIONS WITHIN AND AMONG LARGER EARTH SYSTEMS. THE STUDY OF ACTIVE PROCESSES FROM GEOCENTER MOTION TO THE STUDIES OF THE LITHOSPHERE, CRYOSPHERE, HYDROSPHERE, AND ATMOSPHERE REQUIRES UNDERSTANDING OF THE COUPLING AND FEEDBACKS ACROSS A RANGE OF LENGTH AND TIME SCALES, AND BETWEEN THE SOLID EARTH AND ITS FLUID ENVELOPES, IN BOTH PHYSICAL AND BIOLOGICAL ENVIRONMENTS. UNDER NSF, AND NASA PARTNER AGENCY SUPPORT FOR GAGE, UNAVCO WILL INTEGRATE AND FEDERATE A SET OF CURRENTLY OPERATED BUT AT PRESENT INDEPENDENTLY MANAGED GNSS STATIONS TO FORM THE NETWORK OF THE AMERICAS (NOTA). UNAVCO WILL MODERNIZE NOTA STATIONS WITH STATE-OF-THE-ART, MULTI-SENSOR, MULTI-GNSS, RECEIVERS WITH REAL-TIME STREAMING DATA AND ANALYSIS. THESE ENHANCEMENTS WILL ENABLE HIGHER PRECISION POSITIONING THAN CURRENTLY POSSIBLE AND NEW APPLICATION OF GNSS DATA THAT CAN BE USED FOR GEOHAZARDS WARNING SYSTEMS, STUDY OF OCEAN AND ATMOSPHERE DYNAMICAL BEHAVIOR, AND OBSERVATION OF KEY ENVIRONMENTAL PARAMETERS SUCH AS WATER STORAGE, SOIL MOISTURE, AND SEA AND LAKE-LEVEL CHANGES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

ENABLING DISCOVERIES IN MULTISCALE EARTH SYSTEM DYNAMICS: SEISMOLOGICAL FACILITY FOR THE ADVANCEMENT OF GEOSCIENCE (SAGE) -THE IRIS (INCORPORATED RESEARCH INSTITUTIONS FOR SEISMOLOGY) CONSORTIUM WILL DEVELOP, OPERATE, AND MAINTAIN A DISTRIBUTED, MULTI-USER FACILITY ENTITLED SEISMOLOGICAL FACILITIES FOR THE ADVANCEMENT OF GEOSCIENCE (SAGE). EXPERT PROFESSIONAL STAFF, WITH GUIDANCE PROVIDED BY THE SCIENTIFIC COMMUNITY, WILL MANAGE AND OPERATE A SET OF FOUNDATIONAL CAPABILITIES THAT ARE ESSENTIAL FOR CURRENT RESEARCH SUPPORT, AS WELL AS FRONTIER ACTIVITIES THAT WILL ENABLE FUTURE RESEARCH. THE FACILITY WILL PROMOTE ADVANCES IN OUR UNDERSTANDING OF EARTH STRUCTURE AND DYNAMICS, EARTHQUAKES AND VOLCANIC ERUPTIONS, AND INTERACTIONS BETWEEN THE SOLID EARTH, HYDROSPHERE, AND ATMOSPHERE THROUGH MANAGEMENT AND OPERATION OF: 1) GLOBAL AND REGIONAL CONTINUOUSLY OPERATING SEISMIC NETWORKS, INCLUDING THE GLOBAL SEISMOGRAPHIC NETWORK; 2) PORTABLE GEOPHYSICAL INSTRUMENTATION FOR USE IN PRINCIPAL INVESTIGATOR DRIVEN AND COMMUNITY EXPERIMENTS; 3) DATA MANAGEMENT SYSTEMS FOR THE COLLECTION, QUALITY ASSURANCE, CURATION, MANAGEMENT, AND DISTRIBUTION OF OPEN ACCESS DATA AND DATA PRODUCTS; AND 4) EDUCATION, WORKFORCE DEVELOPMENT, AND PUBLIC OUTREACH PROGRAMS DESIGNED TO BE INCLUSIVE AND ENHANCE PARTICIPATION OF TRADITIONALLY UNDERREPRESENTED GROUPS IN THE GEOSCIENCES. THE SEISMOLOGICAL FACILITIES PROVIDED THROUGH THE SAGE CONTRIBUTE TO ISSUES OF NATIONAL/GLOBAL STRATEGIC IMPORTANCE, INCLUDING GEOHAZARD ASSESSMENT AND DISASTER RESILIENCE; ENVIRONMENTAL MANAGEMENT AND ECONOMIC DEVELOPMENT; NATIONAL SECURITY; AND STEM (SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS) EDUCATION AND WORKFORCE DEVELOPMENT. DATA AND DATA PRODUCTS FROM SAGE WILL BE USED BY STATE AND FEDERAL AGENCIES INCLUDING THE UNITED STATES GEOLOGICAL SURVEY, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, NATIONAL AERONAUTICS AND SPACE ADMINISTRATION, DEPARTMENT OF ENERGY, AND DEPARTMENT OF DEFENSE, FOR MISSION AGENCY ACTIVITIES, INCLUDING EARTHQUAKE MONITORING AND CHARACTERIZATION, TSUNAMI WARNING, WEATHER FORECASTING, WATER AND ENVIRONMENTAL MANAGEMENT, AND NUCLEAR TEST MONITORING. SAGE PROGRAMS WILL ALSO SUPPORT INQUIRY-BASED SCIENCE EDUCATION, ENHANCING STUDENTS' ABILITIES TO ENGAGE DIRECTLY WITH SCIENCE AND ENGINEERING PRINCIPLES AND PRACTICE, AND ENABLING THEM TO PURSUE STEM CAREERS IN ACADEMIA, INDUSTRY, BUSINESS, AND GOVERNMENT. THE SAGE OUTREACH ACTIVITIES PROMOTE PUBLIC ENGAGEMENT AND SCIENCE LITERACY. THE SAGE FACILITY PROVIDES INSTRUMENTATION SERVICES; DATA SERVICES; AND EDUCATION, WORKFORCE DEVELOPMENT, AND COMMUNITY ENGAGEMENT ACTIVITIES IN SUPPORT OF SEISMOLOGY. RESEARCHERS USE SAGE TO GAIN VALUABLE INSIGHTS INTO FUNDAMENTAL EARTH PROCESSES, AND SAGE ALSO PROVIDES KEY DATA FOR NATIONAL SECURITY NEEDS, INCLUDING MONITORING EFFORTS OF CLANDESTINE NUCLEAR TESTS. THE SCIENTIFIC PRIORITIES OF THE NEW FACILITY WOULD ENABLE ADVANCES IN THE FOLLOWING AREAS: (1) GLOBAL EARTH STRUCTURE AND DYNAMICS: THE FACILITY WOULD ENHANCE OUR ABILITY TO RESOLVE THE THREE-DIMENSIONAL STRUCTURE OF THE EARTH'S INTERIOR AND ENABLE INVESTIGATORS TO STUDY PROCESSES THAT DRIVE PLATE TECTONICS AND NATURAL HAZARDS SUCH AS EARTHQUAKES, TSUNAMIS, AND VOLCANIC ERUPTIONS. (2) FAULT ZONES AND THE EARTHQUAKE CYCLE: OVER THE LAST DECADE, SCIENTISTS HAVE DISCOVERED A BROAD ARRAY OF FAULT ZONE SLIP BEHAVIORS THAT SPAN A WIDE VARIETY OF TEMPORAL AND SPATIAL SCALES. THE SAGE FACILITY WILL ENABLE A VARIETY OF SEISMIC AND ELECTROMAGNETIC MEASUREMENTS TO ELUCIDATE HOW THESE DIFFERENT TYPES OF BEHAVIORS START AND STOP, VARY ALONG FAULT ZONES, AND INTERACT WITH ONE ANOTHER. (3) MAGMAS AND VOLATILES IN THE CRUST AND MANTLE: GEOPHYSICAL INSTRUMENTATION IS CRITICAL FOR UNDERSTANDING VOLCANIC SYSTEMS AND MINIMIZING RISKS ASSOCIATED WITH VOLCANIC HAZARDS. THE CAPABILITIES PROVIDED BY SAGE WILL ENABLE RESEARCHERS TO STUDY MELT PRODUCTION, MONITOR ITS TRANSPORT THROUGH THE CRUST, AND MAP OUT THE PLUMBING SYSTEMS OF VOLCANOES. (4) HYDROSPHERE, CRYOSPHERE, AND ATMOSPHERE: AN AREA OF INCREASING COMMUNITY INTEREST IS UTILIZING GEOPHYSICAL MEASUREMENTS TO STUDY PROCESSES AT THE EARTH'S SURFACE. THE SAGE FACILITY WILL PROVIDE OPPORTUNITIES TO STUDY PROCESSES IN THE NEAR-SURFACE, SUCH AS HYDROLOGY, CRYOSPHERIC PROCESSES, AND GLACIER DYNAMICS. (5) EDUCATION, PUBLIC OUTREACH, AND WORKFORCE DEVELOPMENT: SAGE WILL DEVELOP A VARIETY OF EDUCATIONAL RESOURCES AND ENABLE HUNDREDS OF UNDERGRADUATE RESEARCH OPPORTUNITIES. A MAJOR FOCUS OF THE SAGE ACTIVITIES WILL BE ON BROADENING PARTICIPATION OF UNDERREPRESENTED STUDENTS THROUGH IRIS' NEW URBAN GEOSYSTEMS FOCUS. ADDITIONALLY, THE FACILITY WILL DEVELOP ANIMATIONS, SIMULATIONS, AND OTHER VISUALIZATIONS OF EARTH PROCESSES TO HELP INSTRUCTORS AT ALL LEVEL TEACH ABOUT EARTH SCIENCE. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

U.S. COMMUNITY ACCESS TO LAS CUMBRES OBSERVATORY GLOBAL TELESCOPE NETWORK - A TIME-DOMAIN FOLLOW-UP SYSTEM

INVESTING IN INNOVATION- DEVELOPMENT

U.S. COMMUNITY ACCESS TO THE LAS CUMBRES OBSERVATORY GLOBAL TELESCOPE NETWORK - A TIME-DOMAIN FOLLOW-UP SYSTEM

MAGNET SCHOOLS ASSISTANCE

DEVELOPMENT OF PERIVASCULAR SPACE MAPPING TOOLSET AS A DIAGNOSTIC AID FOR ALZHEIMER'S DISEASE - PROJECT SUMMARY ALZHEIMER’S DISEASE (AD) IS A DEVASTATING DISEASE THAT AFFECTS MILLIONS OF AMERICANS AND IMPOSES A HUGE SOCIO- ECONOMIC BURDEN. AD-RELATED COGNITIVE DECLINE IS ASSOCIATED WITH THE ACCUMULATION OF AMYLOID PLAQUES AND TAU TANGLES, WHICH ARE INSUFFICIENTLY CLEARED BY BRAIN CLEARANCE PATHWAYS. PERIVASCULAR SPACE (PVS) CLEARANCE HEALTH PLAYS A SUBSTANTIAL ROLE IN THE NET CLEARANCE OF METABOLIC WASTE FROM THE BRAIN. HUMAN MAGNETIC RESONANCE IMAGING (MRI) STUDIES HAVE SHOWN THAT THE INTEGRITY OF THE PVS, IS A MARKER OF BRAIN CLEARANCE HEALTH AND ITS ALTERATION IS AN IMPORTANT FEATURE OF AD PATHOLOGY. ANOTHER IMPORTANT CLINICAL RELEVANCE OF PVS IN AD HAS BEEN EMERGED BY THE INTRODUCTION OF THE FIRST CLASSES OF AMYLOID CLEARING TREATMENTS (E.G., BIOGEN:ADUHELM OR EISAI:LECANEMAB). ALZHEIMER’S PATIENTS WITH CEREBRAL AMYLOID ANGIOPATHY COMORBIDITY HAVE HIGH LIKELIHOOD OF MANIFESTING AN ADVERSE EVENT CALLED, AMYLOID RELATED IMAGING ABNORMALITIES (ARIA). PVS IS A DIAGNOSTIC CRITERION FOR CEREBRAL AMYLOID ANGIOPATHY (BASED ON BOSTON CRITERIA 2.0). AD PATIENTS ARE REQUIRED TO GO THROUGH MRI BEFORE AND DURING THE TREATMENT FOR ARIA MONITORING AND PVS ASSESSMENT IS AN INTEGRAL PART OF THE MONITORING. PVS INTEGRITY IS THEREFORE AN IMPORTANT CLINICAL FEATURE IN ALZHEIMER’S DISEASE AND VASCULAR DEMENTIA. HENCE, A TOOL THAT ALLOWS NON-INVASIVE IN-VIVO MAPPING OF PVS FROM CLINICAL MRI IS OF HIGH SIGNIFICANCE TO AID AD DIAGNOSIS AND DISEASE MONITORING. SUCH TOOL, HOWEVER, DOES NOT EXIST. CURRENT CLINICAL ROUTINE TO INVESTIGATE PVS IS BASED ON COUNTING TOTAL NUMBER OF OBSERVED PVS IN MRI BY NEURO-RADIOLOGISTS, WHICH IS NON-SPECIFIC, RATER-DEPENDENT, AND DOES NOT CAPTURE THE DISTRIBUTION, WHOLE EXTENT OF PVS CHANGE NOR VOLUMETRIC FEATURES OF THE PVS. IN PRACTICE, THIS TECHNIQUE IS TIME CONSUMING AND LABORIOUS. THESE LIMITATIONS IN PART HAVE PREVENTED NEUROLOGISTS FROM ADOPTING PVS QUANTIFICATION INTO THEIR CLINICAL ROUTINE. NEUROSCOPE HAS DEVELOPED COMPUTATIONAL TECHNIQUES FOR MAPPING AND QUANTIFYING PVS MORPHOLOGY FROM MRI, WHICH ENABLES AUTOMATED AND ACCURATE QUANTIFICATION OF PVS ACROSS THE BRAIN WITHOUT THE NEED FOR TIME CONSUMING MANUAL INTERVENTION. NEUROSCOPE TOOLS WERE CLINICALLY AND TECHNICALLY VALIDATED (PHASE-I-STTR DELIVERABLES), WITH >99.8% TEST-RETEST RELIABILITY, SENSITIVITY, AND SPECIFICITY OF >98% AND >93%, RESPECTIVELY. OUR PATENT APPLICATION ON OUR TOOLS WAS ALSO SUBMITTED IN FEB 2021 AND THEIR EXECUTABLE STABLE VERSION HAVE BEEN IMPLEMENTED ON OUR CLOUD SERVER. NEUROSCOPE IS NOW READY TO BUILD THE COMMERCIAL ECOSYSTEM THAT ENABLES INTERACTION WITH POTENTIAL CUSTOMERS. THE GOAL OF THIS PROPOSAL IS TO DEVELOP THE IT INFRASTRUCTURE REQUIRED TO COMMERCIALIZE OUR PVS MAPPING TECHNOLOGIES AND TO SUBMIT FDA 510(K) APPLICATION. OUR MAIN CUSTOMERS ARE PHARMACEUTICAL COMPANIES AND HOSPITAL RADIOLOGY SECTORS. THE IT INFRASTRUCTURE IS REQUIRED TO PROVIDE SERVICE IN CLINICAL TRIALS AND THE FDA APPROVAL IS REQUIRED TO EXPAND OUR MARKET DOMAIN TO CLINICAL DIAGNOSTICS. NEUROSCOPE HAS IDENTIFIED POTENTIAL CUSTOMERS AND HAVE ALREADY MADE SIGNIFICANT PROGRESS. SEVERAL INDUSTRY LEADING COMPANIES SHOWN INTEREST IN OUR TECHNOLOGY.

SONOGENETIC RESTORATION OF VISION FOR RETINITIS PIGMENTOSA - RETINITIS PIGMENTOSA (RP) OFTEN RESULTS IN LEGAL BLINDNESS AND IS CAUSED BY MORE THAN 100 GENETIC MUTATIONS, MAKING ITS DEVELOPMENT CHALLENGING TO ADDRESS ALL CAUSES WITH GENE THERAPY. FDA APPROVAL OF GENE THERAPY FOR LCA ADDRESSING RPE65 MUTATION HAS SPARKED GREAT ENTHUSIASM AND HOPE FOR DEVELOPING GENE THERAPY. HOWEVER, CLASSICAL GENE REPLACEMENT OR GENE-EDITING-BASED SIGHT-SAVING THERAPIES ARE APPLICABLE WHEN PHOTORECEPTORS DO NOT DEGENERATE. CURRENT SYSTEMS, HOWEVER, ARE LIMITED BY POOR RESOLUTION AND RETINAL DAMAGE OVER A PERIOD. MOST CURRENT CLINICAL TREATMENTS ARE PRIMARILY FOCUSED ON SLOWING DOWN THE PROGRESSION OF THE DISEASE, AS THERE IS NEITHER A CURE THAT CAN STOP THE DEGENERATION NOR A THERAPY OTHER THAN RETINAL PROSTHESES THAT CAN IMPROVE VISION LOSS DUE TO RETINAL DEGENERATION. HOWEVER, THE ELECTRICAL STIMULATION DEVICES ARE INVASIVE AND REQUIRE COMPLEX IMPLANTATION SURGERIES. WE HAVE INVESTIGATED ULTRASOUND STIMULATION FOR THE RETINA AS A MODALITY FOR TREATING RETINAL DEGENERATIVE DISEASES. HOWEVER, SIGNIFICANT CHALLENGES IN TRANSLATING THIS TECHNOLOGY INCLUDE (I) THE REQUIREMENT OF HIGH-INTENSITY ULTRASOUND AND (II) THE LACK OF CELL-SPECIFIC STIMULATION. BY SENSITIZING SPECIFIC RETINAL CELLS (E.G., RETINAL GANGLION CELLS THAT ARE INTACT IN RP) TOWARD ULTRASOUND USING THE HETEROLOGOUSLY-EXPRESSED MECHANOSENSITIVE CHANNEL, THE SONOGENETIC STIMULATION-BASED APPROACH MAY PROVIDE AN ALTERNATIVE THERAPEUTIC MODALITY TO RESTORE VISUAL FUNCTION IN THE DEGENERATED RETINA. NANOSCOPE HAS SCREENED AND ENGINEERED MECHANOSENSITIVE CHANNELS (EMC) FROM DIFFERENT MICROBIAL SPECIES, WHICH UPON EXPRESSION IN MAMMALIAN CELLS AND RETINA, ALLOWS SONOGENETIC STIMULATION BY ULTRASOUND WITH INTENSITY ORDERS OF MAGNITUDE LOWER THAN THAT REQUIRED WITHOUT EMC SENSITIZATION. EMC IS ACTIVATED BY ANY MECHANICAL FORCE THAT CAUSES STRETCH AND DEFORMATION OF THE LIPID BILAYER, SUCH AS STRETCH, PRESSURE/SUCTION, AND ULTRASOUND, AS MEASURED BY PRESSURE CLAMP AND ELECTROPHYSIOLOGY. RGC-SPECIFIC EMC DELIVERY COMBINED WITH EXTERNAL US STIMULATION HAS GENERATED RESTORATION OF VISUAL FUNCTION IN THE RP MICE MODEL. IN THE PROPOSED PROJECT, WE AIM TO UTILIZE SONOGENETIC STIMULATION USING ULTRASOUND ARRAY TRANSDUCERS FOR ACHIEVING VISION RESTORATION IN THE PHOTORECEPTOR-DEGENERATED RETINA. THIS GOAL WILL BE ACHIEVED THROUGH THE FOLLOWING AIMS: AIM 1: IN-VITRO ASSESSMENT OF THE EFFICACY OF EMC BY USE OF FOCUSED ULTRASOUND STIMULATION, AIM 2: IN-VIVO ASSESSMENT OF LOW-POWER ULTRASOUND STIMULATION OF EMC-SENSITIZED RETINA, AIM 3: SONOGENETIC RESTORATION OF VISION IN A RABBIT MODEL OF RETINITIS PIGMENTOSA. THE SUCCESS OF THIS PROPOSED PROJECT WILL LEAD TO THE REALIZATION OF A NON-INVASIVE SONOGENETIC COMBINATION THERAPY FOR VISION RESTORATION IN RETINAL DEGENERATIVE DISEASES.

TARGETED NANO-ENHANCED OPTICAL DELIVERY OF OPSIN FOR DRY-AMD THERAPY

MRI-CONSORTIUM: DEVELOPMENT OF A GREENLAND ICE SHEET MONITORING NETWORK

BIOLUMINESCENT MULTI-CHARACTERISTIC OPSIN FOR SIMULTANEOUS OPTICAL STIMULATION AND LARGE-SCALE MONITORING OF THE VISUAL SYSTEM

AEON+: ENABLING TIME-DOMAIN AND MULTI-MESSENGER FOLLOW-UP AT ALL WAVELENGTHS -THE U.S. HAS BEEN AT THE FOREFRONT OF NEW TECHNOLOGIES THAT HAVE GIVEN US NEW WAYS TO STUDY OBJECTS IN SPACE THAT CHANGE WITH TIME. SOFTWARE CAN ALERT US TO NEW DISCOVERIES, BUT THE DISCOVERY DATA ALONE AREN'T ENOUGH FOR US TO FULLY UNDERSTAND WHAT'S GOING ON. ADDITIONAL OBSERVATIONS ARE REQUIRED, OFTEN FROM SEVERAL DIFFERENT TELESCOPES. THESE FOLLOW-UP OBSERVATIONS ARE OFTEN NEEDED AT SHORT NOTICE, TO HELP US TO UNDERSTAND OBJECTS THAT ARE CHANGING QUICKLY. THIS PROJECT WILL ENABLE ASTRONOMERS TO CONTACT TELESCOPES AND ASK FOR THE OBSERVATIONS THEY NEED USING SOFTWARE. THIS WILL MAKE IT POSSIBLE TO COORDINATE FOLLOW-UP OBSERVATIONS ACROSS OPTICAL, INFRARED AND RADIO TELESCOPES. ASTRONOMERS WILL ALSO BE ABLE TO OBSERVE X-RAY AND UV SIGNALS USING THE SWIFT SPACE TELESCOPE. THE PROJECT WILL ALSO FOSTER COLLABORATIONS BETWEEN OBSERVATORIES AND ASTRONOMERS. THE INVESTIGATORS WILL ORGANIZE A PROGRAM OF WORKSHOPS AND COLLABORATIVE VISITS. BY SHARING EXPERIENCE AND TOOLS, THEY WILL REDUCE DUPLICATION OF EFFORT, AND MAKE TOOLS DEVELOPED BY DIFFERENT TEAMS WORK TOGETHER. TO CHARACTERIZE DISCOVERIES FROM GRAVITATIONAL WAVE, NEUTRINO AND ELECTROMAGNETIC TIME DOMAIN AND MULTI-MESSENGER ASTROPHYSICS (TD/MMA) SURVEYS, IT IS ESSENTIAL TO COORDINATE TIMELY FOLLOW-UP OBSERVATIONS ACROSS THE ELECTROMAGNETIC SPECTRUM FROM MANY DIFFERENT GROUND-AND SPACE-BASED TELESCOPES. THE ASTRONOMICAL EVENT OBSERVATORIES NETWORK (AEON) HAS DEMONSTRATED HOW QUITE DIFFERENT TELESCOPE FACILITIES CAN COLLABORATE TO ENABLE OBSERVATION REQUESTS TO BE SUBMITTED THROUGH APPLICATION PROGRAMMING INTERFACES (APIS) WITH FLEXIBLE MODES OF SCHEDULING. THIS ENABLES THE SCIENCE COMMUNITY TO DIRECTLY REQUEST OBSERVATIONS THROUGH SOFTWARE, STREAMLINING OBSERVING PROGRAMS, WHICH CAN THEN BE AUTOMATED. THIS HAS PROVEN TO ENABLE HIGHLY EFFICIENT AND FLEXIBLE OBSERVATIONS THAT ARE CRITICAL TO PERFORMING TIMELY FOLLOW-UP OF TD/MMA TARGETS. HISTORICALLY, MOST OBSERVATORIES HAVE DEVELOPED THEIR OPERATING SOFTWARE INDEPENDENTLY, LEADING TO A RANGE OF PLATFORMS CUSTOMIZED FOR EACH FACILITY. INSTEAD, THIS PROJECT WILL CREATE A OPEN-SOURCE SOFTWARE LIBRARY THAT CAN SUBMIT OBSERVATIONS TO A WIDE RANGE OF AEON-COMPATIBLE FACILITIES. AS A STAND-ALONE LIBRARY, THIS CODE CAN THEN BE USED WITHIN ANY COMMUNITY-DEVELOPED PLATFORM OR SOFTWARE. IN ADDITION TO FACILITIES THAT ARE ALREADY IN AEON (LAS CUMBRES, SOAR, GEMINI), THIS PROJECT, LED BY THE LAS CUMBRES OBSERVATORY GLOBAL TELESCOPE NETWORK, WILL EXTEND THE NEW LIBRARY TO ENABLE OBSERVATIONS AT THE KECK OBSERVATORIES, THE SKYNET TELESCOPE NETWORK AND FACILITIES OPERATED BY THE NATIONAL RADIO ASTRONOMICAL OBSERVATORY. THE PROJECT WILL HOST REGULAR OBSERVATORIES FORUM WORKSHOPS, BRINGING TOGETHER OBSERVATORY STAFF AND SCIENCE COMMUNITY DEVELOPERS TO SHARE EXPERIENCE AND TOOLS, AND FOSTERING INTEROPERABILITY BETWEEN PLATFORMS. IT WILL ALSO ENABLE STAFF FROM DIFFERENT OBSERVATORIES TO COLLABORATE DIRECTLY BY CREATING A VISITING DEVELOPERS PROGRAM. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

HAG TECHNICAL ASSISTANCE

NATIONAL CENTER FOR EDUCATION RESEARCH

EARTHCUBE BUILDING BLOCKS: DEPLOYING WEB SERVICES ACROSS MULTIPLE GEOSCIENCE DOMAINS

MRI: DEVELOPMENT OF THE GLOBAL NETWORK OF ROBOTIC ECHELLE SPECTROGRAPHS - NRES

BROAD-BAND OPSIN AND TARGETED OPTICAL-DELIVERY FOR RETINITIS PIGMENTOSA TREATMENT

ASSESSING THE IMPACT OF APP-DELIVERED LIGHTING INTERVENTIONS ON FATIGUE IN THREE POPULATIONS OF CANCER PATIENTS

MECHANOSENSITIVE CHANNEL BASED PRESSURE-MODULATING GENE THERAPY FOR GLAUCOMA TREATMENT - GLAUCOMA IS RECALCITRANT TO TREATMENT AND THE RESULTING OPTIC NERVE DAMAGE IS IRREVERSIBLE. ALL DEMOGRAPHICS ARE SUSCEPTIBLE TO GLAUCOMA, ESPECIALLY THE ELDERLY, AFRICAN-AMERICANS, HISPANICS, DIABETICS AND FAMILIES WITH A HISTORY OF GLAUCOMA. ABOUT THREE MILLION AMERICANS HAVE GLAUCOMA AND THE US GOVERNMENT LOSES AN ESTIMATED 3 BILLION USD EACH YEAR IN LOST TAX REVENUE, BENEFIT PAYOUTS AND HEALTHCARE SUBSIDIES NEEDED TO SUPPORT THESE CITIZENS. THERE IS GREAT NEED FOR A LONG-LASTING TREATMENT FOR GLAUCOMA, BECAUSE VISION LOSS DUE TO GLAUCOMA IS THE SECOND LEADING CAUSE OF BLINDNESS IN AMERICA. THE CURRENTLY AVAILABLE PHARMACOLOGICAL AND SURGICAL TREATMENTS FOR GLAUCOMA HAVE SIGNIFICANT LIMITATIONS AND SIDE-EFFECTS, WHICH INCLUDE, SYSTEMIC REACTIONS TO MEDICATIONS, PATIENT NON-COMPLIANCE, EYE INFECTIONS, SURGICAL DEVICE FAILURE, AND DAMAGE TO THE EYE. PRIMARY OPEN ANGLE GLAUCOMA (POAG) IS COMMON AND IS CHARACTERIZED BY POOR DRAINAGE OF AQUEOUS HUMOR THROUGH THE CONVENTIONAL OUTFLOW PATHWAY. HERE, WE PUT FORTH A NOVEL COMMISSION FOR VIRALLY DELIVERED ENGINEERED MECHANOSENSITIVE CHANNEL (EMC) AS A PRESSURE MODULATOR IN THE IMPAIRED TM OF GLAUCOMATOUS EYES. USING THIS PATENT PENDING TECHNOLOGY, WE HAVE DEMONSTRATED THAT EMC IS: (I) FUNCTIONAL IN CULTURED TM CELLS, (II) SUCCESSFULLY TRANSDUCED IN VIVO IN TM CELLS; AND (III) EFFECTIVE IN LOWERING THE IOP IN A MOUSE MODEL OF OCULAR HYPERTENSION WITHOUT (I) NON-TARGETED EXPRESSION (MEASURED BY QPCR); (II) OCULAR DAMAGE (ASSESSED BY OCT); (III) INFLAMMATORY CYTOKINES IN PLASMA (DETECTED BY ELISA); OR (IV) IMMUNE CELL RESPONSE AND (V) LOSS OF VIABILITY OF TARGETED CELLS EXPRESSING EMC OVER LONG PERIOD. EMC IS AN ENGINEERED VERSION OF THE BACTERIAL STRETCH- ACTIVATED CHANNEL, WHICH DIRECTLY SENSES TENSION IN THE MEMBRANE LIPID BILAYER OF CELLS AND IN RESPONSE, TRANSIENTLY OPENS ITS LARGE NON-SPECIFIC PORE FOR TRANS/PARACYTOSIS. AT ITS PRESSURE THRESHOLD, EMC CAN RELEASE FLUID FROM TM CELLS TO BE CLEARED THROUGH SC. ADDITIONALLY, THE RESULTING DECREASE IN CELL VOLUME AND SIZE WILL WIDEN INTERCELLULAR SPACES AND FACILITATE THE PARACELLULAR FLOW OF AQUEOUS HUMOR. EMC ACTS AS AN IDEAL DRAINAGE VALVE FOR TM CELLS, BECAUSE IT IS A RELATIVELY SMALL HOMO-OLIGOMERIC CHANNEL AND DOES NOT NEED ANY ASSOCIATED PROTEINS OR ENERGY SOURCES TO ASSEMBLE AND FUNCTION. WE HAVE IDENTIFIED OPTIMAL EMC VARIANT THAT IS ACTIVATED AT PHYSIOLOGICALLY RELEVANT PRESSURES USING PRESSURE CLAMP. THE GOAL OF THE PROPOSED RESEARCH IS TO FURTHER DEVELOP THE PRODUCT BASED ON THE SELF-COMPLEMENTARY AAV CARRIED ENGINEERED MECHANOSENSITIVE EMC CHANNEL (SCEMC) FOR GENE THERAPY OF POAG. THE OBJECTIVE OF THIS PHASE-II SBIR PROJECT WILL BE ACCOMPLISHED THROUGH THREE SPECIFIC AIMS. AIM 1: QUANTIFY LONG-TERM STABILITY OF SCEMC AND SAFETY OF SCEMC IN WILD TYPE RATS; AIM 2: EVALUATE SCEMC-ENABLED LONG-TERM IOP LOWERING EFFICACY IN RODENT MODELS OF POAG AND AIM 3: GLP STUDY OF TOXICITY AND BIODISTRIBUTION OF INTRACAMERALLY-INJECTED SCEMC IN WILD-TYPE NHPS. THE DEVELOPMENT OF A SAFE EFFECTIVE SINGLE-DOSE LONG-LASTING TREATMENT FOR GLAUCOMA VIA THE SUCCESS OF THIS PROPOSAL WOULD IMPROVE THE LIVES OF MANY AMERICANS.

FRAMEWORKS: TARGET AND OBSERVATION MANAGER SYSTEMS FOR MULTI-MESSENGER AND TIME DOMAIN SCIENCE -CURRENT AND NEAR-FUTURE U.S.-LED ASTRONOMY SURVEYS OFFER A REVOLUTIONARY OPPORTUNITY TO EXPLORE PHYSICAL PHENOMENA THROUGH MULTIPLE MESSENGERS AND INSTRUMENTS, ASSOCIATING GRAVITATIONAL WAVE DETECTIONS WITH NEUTRINO SIGNATURES AND ELECTROMAGNETIC COUNTERPARTS. THE COMBINATION PROVIDES POWERFUL NEW INSIGHTS RELEVANT TO A BROAD RANGE OF RESEARCH IN THE ASTROPHYSICAL AND PHYSICS COMMUNITIES. THE SCALE OF THESE SURVEYS MEANS THAT UNPRECEDENTED, PETABYTE SCALE DATA VOLUMES AND THEIR RAPID DELIVERY MUST BE MANAGED EFFECTIVELY TO FULLY REALIZE THEIR SCIENTIFIC POTENTIAL, BUT THESE DATA ALONE CANNOT FULLY CHARACTERIZE THE DISCOVERIES. ADDITIONAL OBSERVATIONS FROM FACILITIES WITH COMPLEMENTARY INSTRUMENTATION ARE NORMALLY REQUIRED, BUT OBTAINING THESE IN A TIMELY MANNER CAN PRESENT SERIOUS TECHNICAL CHALLENGES, BOTH TO RESEARCHERS TRYING TO IDENTIFY AND CHARACTERIZE TIME-SENSITIVE TARGETS OF INTEREST, AND TO THE INFRASTRUCTURE OF THESE FACILITIES. INNOVATIVE NEW SOFTWARE TOOLS ENABLE RESEARCHERS TO EASILY BUILD A DATABASE TO MANAGE ALL ASPECTS OF THEIR SCIENCE PROJECTS, INCLUDING CONDUCTING OBSERVATIONS, THROUGH A SINGLE PROGRAMMATIC INTERFACE. THE CAPABILITIES OF THESE TOOLS ARE EXPANDING TO ENSURE THAT THEY ARE SEAMLESSLY INTEGRATED WITH OTHER, RAPIDLY DEVELOPING LINCHPIN SCIENTIFIC SOFTWARE SERVICES, ESPECIALLY THE RANGE OF FACILITIES WHERE FOLLOW-UP OBSERVATIONS ARE CONDUCTED. THIS PROVIDES A CRITICAL LINK IN THE CHAIN OF DISCOVERY AND CHARACTERIZATION FOR MANY LANDMARK SURVEYS. YET HISTORICALLY, SUCH SOPHISTICATED DATABASE-DRIVEN SYSTEMS HAVE ONLY BEEN AVAILABLE TO LARGER PROJECTS AND INSTITUTIONS WITH IN-HOUSE SOFTWARE TEAMS. THIS PERPETUATES INEQUITABLE ACCESS TO THE SCIENTIFIC POTENTIAL OF MAJOR TAXPAYER-FUNDED FACILITIES. THE WELL-DOCUMENTED OPEN SOURCE SOFTWARE PACKAGE TO BE DEVELOPED IN THIS PROJECT, CALLED THE TOM (TARGET AND OBSERVATION MANAGER) TOOLKIT, AND AN ASSOCIATED COMMUNITY DEVELOPMENT PROGRAM, WILL MAKE THESE PROFESSIONAL RESEARCH TOOLS ACCESSIBLE TO EVERYONE, INCLUDING EDUCATORS AND CITIZEN SCIENTISTS. ENSURING THAT RESEARCHERS CAN RECEIVE INFORMATION ON NEW DISCOVERIES RAPIDLY, MANAGE AND EVALUATE ALL RELEVANT DATA ON TARGETS OF INTEREST, AND CONDUCT FOLLOW-UP OBSERVATIONS IN A TIMELY AND EFFECTIVE MANNER, IS ESSENTIAL TO REALIZING THE SCIENTIFIC POTENTIAL OF MODERN MAJOR ASTRONOMICAL SURVEYS AND MISSIONS. PETABYTE-SCALE DATA PRODUCTS, DELIVERED IN REAL-TIME, ARE USEFUL ONLY IF WE CAN ADEQUATELY HANDLE THE DATA RATE. RECOGNIZING THIS, MUCH EFFORT HAS BEEN INVESTED IN GENERATING THE SURVEY DATA PRODUCTS, BUT THE TOOLS USED BY MOST RESEARCHERS TO DO SCIENCE INVESTIGATIONS WITH THESE PRODUCTS ARE OFTEN AN AD HOC COMBINATION OF TEXT FILES, SPREADSHEETS AND OTHER APPLICATIONS THAT DO NOT SCALE WELL AND ARE NOT DESIGNED TO OPERATE WITH OTHER KEY SERVICES. THE BIG DATA ERA DEMANDS SCIENTIFIC PROJECT MANAGEMENT SOFTWARE THAT INTERFACE WITH EXISTING SERVICES, SUCH AS DISCOVERY ALERT BROKERS AND TELESCOPES, TO ENABLE SCIENTISTS TO EFFECTIVELY COLLATE INFORMATION RELEVANT TO THEIR INTERESTS, AND TO MANAGE ALL ASPECTS OF FOLLOW-UP OBSERVING PROGRAMS. MODERN, BROWSER-BASED DATA EXPLORATION AND VISUALIZATION TOOLS ENABLE A DIVERSE RANGE OF SCIENCE, AND WELL-DESIGNED PUBLIC SOFTWARE CAN ENSURE THAT RESEARCHERS SPEND TIME USING THESE TOOLS FOR SCIENCE INSTEAD OF REPEATEDLY RE-INVENTING THEM. A PARTNERSHIP BETWEEN RESEARCHERS AND SOFTWARE ENGINEERS ENSURES THAT SCIENCE CAN TAKE ADVANTAGE OF THE LATEST DEVELOPMENTS FROM INDUSTRIES WHERE HANDLING BIG DATA IS ALREADY STANDARD. THE TOM SOFTWARE PACKAGE PROVIDES THIS CRITICAL TOOL SET, ENSURES THAT IT REMAINS FULLY INTEGRATED WITH THE EVOLVING SERVICES IN THE FIELD, AND EXPANDS ITS CAPABILITIES TO MEET THE NEEDS OF USERS. THIS PROJECT ADVANCES THE GOALS OF THE NSF WINDOWS ON THE UNIVERSE BIG IDEA. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

REAL-WORLD TRANSLATION OF A DYNAMIC AND PERSONALIZED INTERVENTION FOR SHIFT WORKERS - PROJECT SUMMARY SHIFT WORKERS EXPERIENCE PROFOUND CIRCADIAN DISRUPTION, WHICH CAN HAVE DELETERIOUS LONG TERM EFFECTS ON THEIR HEALTH AND QUALITY OF LIFE. DUE TO THE NECESSITY OF NIGHT SHIFT WORK FOR 24-7 CONTINUOUS OPERATIONS AND SAFETY, IT IS URGENT THAT SOCIETY PRIORITIZE WAYS TO SUPPORT SHIFT WORKER HEALTH. MOOD, FATIGUE, AND PERFORMANCE CAN BE IMPROVED IN SHIFT WORKERS BY SHIFTING THE TIMING OF PRODUCTION OF THE HORMONE MELATONIN OUTSIDE THE HOURS THEY ARE EXPECTED TO WORK. THIS CAN BE ACHIEVED WITH A TARGETED LIGHTING INTERVENTION, AS LIGHT IS THE PRIMARY INPUT TO THE BODY’S CIRCADIAN CLOCK, AND SUPPORTED BY BEHAVIORAL INTERVENTIONS, INCLUDING MEAL AND EXERCISE TIMING. CRAFTING SUCH AN INTERVENTION FOR AN INDIVIDUAL, HOWEVER, REQUIRES KNOWLEDGE OF THE PERSON’S CURRENT BIOLOGICAL TIME, OR CIRCADIAN STATE, WHICH HAS TRADITIONALLY BEEN EXTREMELY CHALLENGING TO ASSESS IN SHIFT WORKERS. THE GOLD STANDARD MEASURE OF CIRCADIAN TIMING IS DIM LIGHT MELATONIN ONSET, OR DLMO. FOR DAY WORKERS, DLMO MOST COMMONLY OCCURS IN A SIX HOUR WINDOW PRIOR TO HABITUAL BEDTIME. FOR FIXED NIGHT SHIFT WORKERS, HOWEVER, DLMO CAN OCCUR ANYTIME OVER THE 24-HOUR DAY. THIS REQUIRES 24 HOURS OF MELATONIN COLLECTION IN ORDER TO ARRIVE AT A SINGLE INDICATOR OF INTERNAL TIME, WHICH IS OFTEN PROHIBITIVELY TIME CONSUMING AND EXPENSIVE. THE SMALL BUSINESS ON THIS PROPOSAL, ARCASCOPE, HAS DEVELOPED NEW TECHNIQUES FOR NONINVASIVELY PREDICTING CIRCADIAN TIMING THROUGH CONSUMER WEARABLE DEVICES (E.G. APPLE WATCH) IN COLLABORATION WITH RESEARCH PARTNER ORGANIZATION HENRY FORD. THESE TECHNIQUES CAN ACCURATELY PREDICT DLMO TIMING IN SHIFT WORKING ADULTS USING CONSUMER WEARABLE DEVICES. THE PIS OF THIS GRANT HAVE ALSO DEVELOPED MATHEMATICAL TECHNIQUES FOR GENERATING LIGHTING RECOMMENDATIONS BASED ON PREDICTED CIRCADIAN TIMING, AIMED AT SHIFTING THE PEAK CIRCADIAN DRIVE TO SLEEP OUTSIDE THE WINDOW OF WORKING HOURS. THESE TECHNIQUES HAVE BEEN EVALUATED IN A PHASE I STTR, THROUGH THE DEPLOYMENT OF AN IOS MOBILE APP, SHIFT, WHICH ACHIEVED LARGE PHASE SHIFTS IN REAL WORLD NIGHT SHIFT WORKERS, DEMONSTRATING THAT IT IS POSSIBLE TO SHIFT THEIR CIRCADIAN RHYTHMS SO THAT THE MELATONIN SECRETION OCCURS OUTSIDE THEIR WORKING HOURS. THE NEXT STEP IN THIS WORK IS TO MOVE BEYOND FEASIBILITY AND TOWARDS EFFECTIVENESS AND IMPLEMENTATION. IN PARTICULAR, IT REMAINS TO BE DEMONSTRATED THAT THE MOBILE APP CAN PRODUCE MEANINGFUL CHANGES IN STAKEHOLDER-CENTERED OUTCOMES IN LARGE, RIGOROUSLY TESTED COHORTS. THESE OUTCOMES INCLUDE NOT ONLY WORKER HEALTH OUTCOMES, SUCH AS DEPRESSION AND SLEEP HEALTH, BUT ALSO QUANTITIES OF CRITICAL IMPORT TO THEIR EMPLOYERS FINANCES, INCLUDING WORKER TURNOVER, SAFETY, AND HEALTH COVERAGE COSTS. IN THIS PHASE II PROJECT, WE PROPOSE TO EVALUATE HOW THE SHIFT APP CAN AFFECT THESE OUTCOMES, DEMONSTRATE NONINFERIORITY OF AN ANDROID VERSION, AND ASSESS KEY FACILITATORS AND BARRIERS TO ENGAGEMENT AND IMPLEMENTATION.

GREENLAND ICE SHEET MONITORING NETWORK (GLISN) OPERATIONS

SEC. 9007 REAP-RENEW ENERGY SYS GRANTS (MAN)

MRI: ACQUISITION FOR INTEGRATING GLOBAL REPORTING GEOPHYSICAL OBSERVATORIES WITHIN THE CHILEAN NATIONAL SEISMIC NETWORK (GRGOC)

RAPID RESPONSE TOXICOLOGY PREDICTION PLATFORM

INTELLIGENT BIOMETRICS TO OPTIMIZE PROLONGED EXPOSURE TREATMENT FOR PTSD (IB-PE)

COLLABORATIVE RESEARCH: OPENTOPOGRAPHY - A CYBERINFRASTRUCTURE FACILITY FOR ADVANCING GEOSCIENCE RESEARCH AND EDUCATION

CDS&E: WOU-MMA: THE TREASURE MAP -THIS PROJECT FOCUSES ON THE TREASURE MAP, A WEB SERVICE FOR COORDINATING, VISUALIZING, AND FACILITATING SEARCHES FOR THE ASTRONOMICAL SOURCES THAT CAN LEAD TO GRAVITATIONAL WAVE EVENTS. WHEN A GRAVITATIONAL WAVE TELESCOPE, SUCH AS LIGO/VIRGO, SENDS AN ALERT, IT IS IMMEDIATELY DISPLAYED ON THE TREASURE MAP, ALLOWING SCIENTISTS TO OBSERVE THE SOURCE WITH OTHER TELESCOPES AT A VARIETY OF WAVELENGTHS. THE SCIENTISTS CAN ALSO ADD INFORMATION ABOUT THEIR OWN OBSERVATIONS, SO THAT THE ASTRONOMICAL COMMUNITY KNOWS WHAT FOLLOW-UP OBSERVATIONS ARE BEING MADE. THIS PROJECT ADDRESSES THE WINDOWS ON THE UNIVERSE BIG IDEA ?CRITERION FOR COORDINATION: HARDWARE, SOFTWARE, OR OTHER INFRASTRUCTURE TO COORDINATE OBSERVATIONS INVOLVING MORE THAN ONE MESSENGER.?? A MECHANISM TO BETTER COORDINATE OBSERVATIONS ACROSS THE ELECTROMAGNETIC SPECTRUM IS CRITICAL TO THE DISCOVERY OF THE NEXT COUNTERPART TO ONE OF THESE SIGNIFICANT EVENTS.? WITH THIS PROJECT, THE AUTHORS WILL TRANSITION THE TREASURE MAP FROM A BETA VERSION TO A MORE ROBUST, MODULAR, WELL-DOCUMENTED COMMUNITY RESOURCE, AS WELL AS ADD ADDITIONAL FUNCTIONALITY. TREASURE MAP IS FREE, OPEN-SOURCED, AND WEB-BASED, AND THE PROJECT WILL RESULT IN NEW TOOLS FOR CLASSROOM ACTIVITIES AS WELL. THE TREASURE MAP IS A WEB SERVICE FOR COORDINATING, VISUALIZING, AND FACILITATING SEARCHES FOR THE ELECTROMAGNETIC COUNTERPART TO GRAVITATIONAL WAVE EVENTS. USERS SEE LOCALIZATION PROBABILITY CONTOURS PROJECTED ON A VISUALIZATION SHOWING THE ENTIRE CELESTIAL SPHERE CONSISTING OF A BASE LAYER DISPLAYING THE USER?S SURVEY OF CHOICE SPANNING X-RAYS TO INFRARED WAVELENGTHS. OBSERVERS MAY SUBMIT THEIR PLANNED OR COMPLETED TELESCOPE POINTINGS USING AN APPLICATION PROGRAM INTERFACE (API), AND THESE ARE SHOWN ON THE VISUALIZATION. A PROBABILITY CALCULATOR ALSO SHOWS THE FRACTION OF THE LOCALIZATION PROBABILITY SEARCHED OVER TIME, BROKEN DOWN BY INSTRUMENT AND BANDPASS. THE AUTHORS WILL TRANSITION THE TREASURE MAP FROM A BETA VERSION TO A MORE ROBUST, MODULAR, WELL-DOCUMENTED COMMUNITY RESOURCE, AND ADD FUNCTIONALITY: GALAXY CATALOG ANNOTATION, ELECTROMAGNETIC COUNTERPART INFORMATION, SUPPORT FOR NEUTRINO LOCALIZATIONS, TOM TOOLKIT SUPPORT, NEXT GENERATION GCN CIRCULAR SUPPORT, NEXT GENERATION KAFKA MESSAGING SUPPORT WITH HOPSKOTCH, AND BROKER SUPPORT. THE TREASURE MAP WILL LOWER THE BARRIER FOR CONTRIBUTION TO GRAVITATIONAL WAVE SCIENCE AND INCREASE INCLUSION: ANYONE CAN FOLLOW THE SEARCH IN REAL TIME. THIS PROJECT WILL PROVIDE NEW TOOLS FOR CLASSROOMS, SUCH AS AN ACTIVITY TO THE SPACEBOOK, BUILDING ON LCO?S GLOBAL SKY PROGRAM TO INCREASE COMMUNITY ENGAGEMENT WITH MULTIMESSENGER ASTRONOMY. THIS PROJECT ADDRESSES THE WINDOWS ON THE UNIVERSE BIG IDEA ?CRITERION FOR COORDINATION: HARDWARE, SOFTWARE, OR OTHER INFRASTRUCTURE TO COORDINATE OBSERVATIONS INVOLVING MORE THAN ONE MESSENGER.?? THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

EARTHCUBE BUILDING BLOCKS: COLLABORATIVE PROPOSAL: DEPLOYING MULTI-FACILITY CYBERINFRASTRUCTURE IN COMMERCIAL AND PRIVATE CLOUD-BASED SYSTEMS

SPEEDING UP THE MESSENGER: IMMEDIATE DETECTION OF MULTIMESSENGER TRANSIENTS WITH LAS CUMBRES OBSERVATORY

INTENSE PERIODS OF SPACE WEATHER MOSTLY IN THE FORM OF CHARGED PARTICLES EMANATING FROM THE SUN CAN INTERACT WITH AND PERTURB THE EARTH'S GEOMAGNETIC FIELD. THIS ACTIVITY INDUCES ELECTRIC FIELDS IN EARTH'S UPPERMOST LAYERS. THE ELECTRICAL PROPERTIES OF THE BASEMENT ROCK EXPERIENCING THESE GEOMAGNETICALLY INDUCED CURRENTS (GICS) CAN INADVERTENTLY CONDUCT THESE CURRENTS INTO HUMAN INFRASTRUCTURE (ELECTRIC POWER GRIDS PIPELINES ETC.) INSTEAD WITH POTENTIAL FOR SIGNIFICANT DAMAGE. THE VULNERABILITY OF CIVIL INFRASTRUCTURE TO GICS HAS BECOME WELL DOCUMENTED IN RECENT YEARS. FOR INSTANCE A REPEAT OF THE LARGEST SPACE WEATHER EVENT IN MODERN HISTORY THE 1859 CAR-RINGTON EVENT WITH TODAY'S INFRASTRUCTURE WOULD POTENTIALLY CAUSE TRILLIONS OF DOLLARS IN DAMAGE AND LEAVE LARGE SECTIONS OF NORTH AMERICA WITHOUT ELECTRIC POWER FOR MONTHS TO YEARS. COLLECTING MAGNETOTELLURIC OBSERVATIONS RECORDS OF THE EARTH'S AMBIENT TIME-VARYING TELLURIC (ELECTRICAL) AND GEOMAGNETIC FIELDS AT A SPECIFIC LOCATION ALLOWS INVESTIGATORS TO CHARACTERIZE THE THREE-DIMENSIONAL CONDUCTIVITY OF THE UNDERLYING EARTH S CRUST AND UPPER MANTLE TO ELECTRICAL CUR-RENTS. IF SURVEYED ON A REGIONAL SCALE THESE MEASUREMENTS CAN BE USED TO PREDICT THE MAGNITUDE OF GICS IN LARGE-SCALE INFRASTRUCTURE AND INFORM THE DEVELOPMENT OF STRATEGIES TO MITIGATE THESE EFFECTS. SINCE 2006 APPROXIMATELY TWO-THIRDS OF THE NORTHERNMOST CONTERMINOUS U.S. HAS BEEN SURVEYED AS PART OF A NATIONAL SCIENCE FOUNDATION PROGRAM CALLED EARTHSCOPE PROVIDING VALUA-BLE CONSTRAINTS FOR UNDERSTANDING GIC HAZARDS. HERE WE PROPOSE TO CONTINUE THIS EFFORT BY COL-LECTING ~52 MAGNETOTELLURIC STATION SITES IN CENTRAL AND SOUTHERN CALIFORNIA. THESE DATA WILL ALLOW FOR THE ASSESSMENT OF GIC VULNERABILITIES ALONG THE WEST COAST OF THE U.S. AND WILL BE OPENLY AVAILABLE TO ANY USERS FOR GENERAL SCIENCE APPLICATIONS IN EARTH AND GEOSPACE SCIENCE.

AIRBORNE NANOPARTICLES FOR THERAPEUTIC APPLICATIONS

REAL-TIME CHARACTERIZATION OF INHALER DOSES

COLLABORATIVE RESEARCH: SUSTAINED RESOURCES: OPENTOPOGRAPHY - AN AI-READY CYBERINFRASTRUCTURE FACILITY FOR ADVANCING OUR UNDERSTANDING OF A CHANGING EARTH -THIS PROJECT WILL CONTINUE THE DEVELOPMENT AND OPERATIONS OF THE OPENTOPOGRAPHY (OT) CYBERINFRASTRUCTURE PLATFORM TO PROVIDE SEAMLESS WEB-BASED ACCESS TO TOPOGRAPHIC DATA FROM TECHNOLOGIES SUCH AS LIDAR, ALONG WITH PROCESSING TOOLS AND EDUCATION AND TRAINING RESOURCES. WITH THE MOST COMPREHENSIVE COLLECTIONS OF TOPOGRAPHIC DATA ON THE INTERNET, OT ENABLES FUNDAMENTAL GEOSCIENCE DISCOVERIES AND INNOVATIVE APPLICATIONS WITH SOCIETAL VALUE ADDRESSING HAZARDS, RESILIENCE, AND EDUCATION. CENTRALIZED ACCESS TO HIGH RESOLUTION TOPOGRAPHIC DATA PROVIDES A BASELINE OF THE EARTH?S SURFACE, VEGETATION, AND BUILT ENVIRONMENT, AND FURTHERS GEOSCIENTIFIC KNOWLEDGE, ADVANCES EDUCATION, AND BROADENS SOCIETAL IMPACTS. OPEN-ACCESS TOPOGRAPHIC DATA OFFER GREAT POTENTIAL TO INCREASE RESILIENCY IN COMMUNITIES THAT LACK RESOURCES TO MITIGATE NATURAL HAZARDS. OT?S EDUCATION, COMMUNITY ENGAGEMENT, WORKFORCE DEVELOPMENT, AND GOVERNANCE ARE DESIGNED TO ENSURE BROAD AND ACTIVE PARTICIPATION. OT WILL ADVANCE SCIENCE AND EDUCATION FOR THE BROADER ACADEMIC COMMUNITY AND PROVIDE A COMPREHENSIVE PLATFORM FOR FAIR (FINDABLE, ACCESSIBLE, INTEROPERABLE, REUSABLE) TOPOGRAPHY DATA MANAGEMENT, PUBLICATION, AND CITATION. THE OT PLATFORM WILL SUPPORT NEW ARTIFICIAL INTELLIGENCE AND MACHINE LEARNING USE CASES AS WELL AS ADDITIONAL CAPABILITIES FOR FACILITATING TRUSTWORTHY AND REPRODUCIBLE SCIENCE. OT WILL ENABLE NEW TOPOGRAPHIC DATA PROCESSING CAPABILITIES OVER LARGER SPATIAL AREAS AND ACROSS BROADER TIME SPANS, ENABLING WIDE USE OF OT ACROSS EARTH SCIENCE DOMAINS AND EDUCATIONAL LEVELS. OT WILL EXPAND KNOWLEDGE OF TOPOGRAPHY DATA TO NEW COMMUNITIES AND SUPPORT WORKFORCE DEVELOPMENT VIA A MULTI-TIERED PLAN INCLUDING COLLABORATION WITH COMMUNITY COLLEGE FACULTY. EDUCATION AND OUTREACH ACTIVITIES INCLUDE WEBINARS, EDUCATIONAL VIDEOS ON TOPOGRAPHY, IN-PERSON SHORT COURSES AT NATIONAL MEETINGS, AND ENTRY-LEVEL UNDERGRADUATE CURRICULUM DEVELOPED IN COLLABORATION WITH COMMUNITY COLLEGE FACULTY. THIS AWARD BY THE GEOINFORMATICS PROGRAM IN THE DIVISION OF EARTH SCIENCES IS JOINTLY SUPPORTED BY THE NATIONAL DISCOVERY CLOUD FOR CLIMATE INITIATIVE WITHIN THE DIRECTORATE FOR COMPUTER AND INFORMATION SCIENCE AND ENGINEERING. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

REU SITE: IRIS UNDERGRADUATE SUMMER RESEARCH IN SEISMOLOGY

COLLABORATIVE MRI: DEVELOPMENT OF GEOPHYSICAL EARTH OBSERVATORY FOR ICE COVERED ENVIRONMENTS (GEOICE)

REU SITE: IRIS UNDERGRADUATE SUMMER RESEARCH IN SEISMOLOGY

LAS CUMBRES OBSERVATORY (LCO) HAS BEEN OPERATING THE FIRST PHASE OF A DISTRIBUTED TELESCOPE NETWORK FOR NEARLY THREE YEARS. THE TELESCOPE NETWORK NOW CONSISTS OF TWO 2-METER TELESCOPES ONE EACH AT A SITE IN EACH HEMISPHERE NINE 1-METER TELESCOPES WITH ONE TELESCOPE AT ONE LOCATION IN THE NORTHERN HEMISPHERE AND EIGHT TELESCOPES AT THREE LOCATIONS IN THE SOUTHERN HEMISPHERE. THE GLOBAL COVERAGE OF THE NETWORK AND THE APERTURES OF TELESCOPE AVAILABLE MAKE THE LCO NETWORK IDEAL FOR FOLLOW-UP AND CHARACTERIZATION OF A WIDE RANGE OF SOLAR SYSTEM OBJECTS (E.G. ASTEROIDS KUIPER BELT OBJECTS COMETS) AND IN PARTICULAR NEAR-EARTH OBJECTS (NEOS). WE HAVE BEEN UTILIZING THE TWO 2-METER TELESCOPES AND NINE 1-METER TELESCOPES AS PART OF THE 'LCOGT/LCO NEO FOLLOW-UP NETWORK' SINCE 2013 AND THIS PROGRAM WAS GREATLY ENHANCED WITH THE RECEIPT OF A NASA NEOO GRANT FROM THE ROSES2013 PROGRAM. THE COMBINATION OF ALL-SKY ACCESS LARGE APERTURE RAPID RESPONSE ROBOTIC OPERATION AND GOOD SITE CONDITIONS HAVE ALLOWED US TO PROVIDE TIME-CRITICAL FOLLOW-UP ASTROMETRY AND PHOTOMETRY ON NEWLY DISCOVERED OBJECTS AND FAINT OBJECTS ALLOWING THE ORBITAL ARC TO BE EXTENDED AND PREVENTING LOSS OF OBJECTS. THE LCO NEO FOLLOW-UP NETWORK IS NOW PROVIDING IMPORTANT NEO FOLLOW-UP FOR THE SURVEYS PARTICULARLY IN THE SOUTHERN HEMISPHERE WHERE LCO HAS A LARGE CONCENTRATION OF TELESCOPES AND OTHER RESOURCES ARE SCARCE. DURING THE PREVIOUS NASA NEOO GRANT WE HAVE BUILT AND DEPLOYED A NEW OBSERVING PORTAL (NEOEXCHANGE) WHICH COLLECTS AND AGGREGATES DATA FOR A VARIETY OF SOLAR SYSTEM OBJECTS FROM THE MPC AND THE PLANETARY RADAR AND NASA TARGET LISTS. NEOEXCHANGE ALLOWS THE PLANNING AND SCHEDULING OF TELESCOPIC OBSERVATIONS AND THE ANALYSIS AND REPORTING OF THE DATA FOR MULTIPLE USERS RUNNING DIFFERENT OBSERVING PROGRAMS ON THE LCO NETWORK. WE WISH TO CONTINUE OUR SUCCESSFUL PROGRAM OF ROBOTIC OBSERVATIONS OF NEOS AND OTHER SOLAR SYSTEM OBJECTS THAT ARE BEING CARRIED OUT WITH THE LCO NEO FOLLOW-UP NETWORK AND ITS NEOEXCHANGE PORTAL AND EXTEND IT TO ALLOW FASTER AND MORE AUTOMATED RESPONSES AND TO FURTHER INCREASE THE THROUGHPUT OF CANDIDATES THAT ARE CONFIRMED. IN ADDITION WE WISH TO MAKE PHOTOMETRIC CHARACTERIZATION AND ANALYSIS OF HIGH VALUE NEOS AUTOMATIC AND ROUTINE. THESE HIGH VALUE NEOS ARE THOSE THAT ARE SCHEDULED FOR RADAR OBSERVATION COULD BECOME POTENTIAL MISSION DESTINATIONS FOR SPACECRAFT OR THAT HAVE POTENTIAL CLOSE-APPROACHES TO THE EARTH. WE CAN ACCOMPLISH THIS THROUGH THE AUTOMATED SCHEDULING AND ANALYSIS OF MULTI-COLOR (INCLUDING QUASI-SIMULTANEOUS OBSERVATIONS MAKING USE OF LCO'S MULTIPLE TELESCOPES AT ONE SITE) AND TIME-SERIES OBSERVATIONS. THIS PROPOSAL IS HIGHLY RESPONSIVE TO THE GOALS OF THE NEOO PROGRAM BY HELPING TO INVENTORY AND CHARACTERIZE NEOS DOWN TO SMALL SIZES. THIS DIRECTLY ADDRESSES THE CONGRESSIONALLY-MANDATED GOAL OF TRACKING AND CHARACTERIZING 90% OF THOSE NEOS THAT ARE GREATER THAN 140 METERS IN DIAMETER. COMBINING THE ASTROMETRY WITH ENHANCED DATA SUCH AS COLORS ROTATION RATES AND SPECTRA WILL ALLOW BETTER CHARACTERIZATION OF POTENTIALLY DANGEROUS EARTH-CROSSING OBJECTS AND POTENTIAL NEAR-EARTH NASA SPACECRAFT MISSION TARGETS. ENHANCEMENT AND STREAMLINING OF THE OBSERVATION PLANNING SCHEDULING AND DATA ANALYSIS WILL ALLOW US TO ABLE TO RAPIDLY RESPOND TO THE SHORT WINDOW OF OBSERVATIONAL OPPORTUNITY FOR TARGETS SMALLER THAN 100 METERS WILL ALSO ENHANCE THE RESPONSE TO THE HAZARD POSED BY CLOSE-PASSING SMALL OBJECTS.

EARLY ROBOTIC SPECTRA OF SUPERNOVAE WITH FLOYDS

PREPARING FOR SCIENCE WITH THE RUBIN OBSERVATORY: GROUNDWORK TO EXPLORE THE GALACTIC POPULATION OF EXOPLANETS -A TEAM LED BY THE UNIVERSITY OF CALIFORNIA-SANTA CRUZ WILL TEST IDEAS OF PLANET, STAR AND BLACK HOLE FORMATION TO COMPARE PREDICTIONS WITH MEASUREMENTS OF REAL-WORLD DISCOVERIES. THE VERA C. RUBIN OBSERVATORY'S LEGACY SURVEY OF SPACE AND TIME (LSST), WILL PRODUCE A GROUNDBREAKING SET OF DISCOVERIES. IT WILL FIND PLANETS, STARS, AND BLACK HOLES AT GREATER DISTANCES ACROSS THE GALAXY THAN HAS EVER BEEN PROBED BEFORE. BUT THE SURVEY DATA ALONE CANNOT FULLY CHARACTERIZE THESE DISCOVERIES. THIS PROJECT WILL MAKE SURE THAT SCIENTISTS ARE READY TO RESPOND TO LSST DISCOVERIES IN REAL-TIME. THE TEAM WILL BUILD THE SOFTWARE NEEDED TO CHARACTERIZE THE DISCOVERIES AND UNDERSTAND THE POPULATIONS OF PLANETS, STARS AND BLACK HOLES. THE SOFTWARE THEY PRODUCE WILL BE PUBLICLY AVAILABLE TO BENEFIT EVERYONE. THE TEAM WILL UPGRADE THEIR FREE EDUCATIONAL WEBSITE, TO HELP STUDENTS LEARN ABOUT THESE FASCINATING DISCOVERIES. CHARACTERIZING RAPIDLY EVOLVING TRANSIENT PHENOMENA LIKE MICROLENSING EVENTS REQUIRES A DEMANDING, RAPID-RESPONSE PROGRAM TO IDENTIFY CANDIDATES FROM THE FLOOD OF SURVEY DATA IN REAL-TIME. THIS PROJECT WILL BUILD THE OBSERVATIONAL AND THEORETICAL INFRASTRUCTURE NECESSARY TO CHARACTERIZE A LARGE SAMPLE OF EVENTS DISCOVERED BY THE VERA C. RUBIN LSST, AND MAKE THE RESULTING TOOLS AVAILABLE TO THE WHOLE COMMUNITY. THE TEAM WILL EXTEND OUR ALGORITHM TO PRIORITIZE MICROLENSING EVENTS IN REAL-TIME BASED ON DISCOVERY ALERTS FROM LOW-CADENCE SURVEYS LIKE LSST, ALLOWING CHARACTERIZATION OBSERVATIONS TO BE MADE IN A TIMELY MANNER. THEY WILL DEVELOP THE ANALYTICAL AND SOFTWARE FRAMEWORK NECESSARY TO MODEL THE LARGE SAMPLE OF EVENTS EXPECTED FROM RUBIN, UNDERSTAND THE SELECTION BIASES, AND INTERPRET THE SAMPLE OF DETECTED EVENTS IN TERMS OF THE UNDERLYING POPULATIONS. IN THE PROCESS, THE TEAM WILL EVALUATE THE LSST SURVEY STRATEGY TO DETERMINE WHERE ADDITIONAL OBSERVATIONS WILL PRODUCE THE GREATEST SCIENTIFIC YIELD AND THEREBY OPTIMIZE OUR FOLLOW-UP STRATEGY. THIS WILL BE PARTICULARLY IMPORTANT IN COORDINATING RUBIN'S SURVEY STRATEGY TO COMPLEMENT THAT OF THE NANCY ROMAN SPACE TELESCOPE'S CONTEMPORANEOUS EXOPLANET SURVEY. ALL OF THE TEAM'S SOFTWARE TOOLS WILL BE OPEN SOURCE AND PUBLICLY AVAILABLE TO BENEFIT THE WHOLE COMMUNITY, AND THE TEAM WILL EXTEND THE TRAINING MATERIALS AVAILABLE FROM OUR EDUCATIONAL WEBSITE TO MAKE THIS SUBJECT MORE ACCESSIBLE TO THE NEXT GENERATION OF STUDENTS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

LAS CUMBRES OBSERVATORY GLOBAL TELESCOPE NETWORK (LCOGT) IS COMPLETING THE DEPLOYMENT OF A DISTRIBUTED TELESCOPE NETWORK THAT WILL CONSIST OF OVER 35

REVEALING SUPERNOVA PROGENITORS WITH LAS CUMBRES OBSERVATORY

IN TRYING TO UNDERSTAND PLANET FORMATION ONE OF THE MOST POWERFUL TOOLS WE HAVE IS TO COMPARE THE DISTRIBUTIONS OF THE PHYSICAL AND ORBITAL PROPERTIES OF THE PLANETS DISCOVERED WITH THOSE PREDICTED BY FORMATION AND EVOLUTIONARY MODELS. FOR THIS TO BE EFFECTIVE WE NEED A COMPLETE CENSUS OF PLANETARY SYSTEMS AT ALL MASSES AND ORBITAL SEPARATIONS. BUT NO ONE SURVEY TECHNIQUE IS SENSITIVE TO THE WHOLE PARAMETER SPACE. KEPLER PROVIDED A LANDMARK CATALOG OF PLANETS AT SMALL ORBITAL RADII AROUND THEIR HOST STARS COMPLEMENTING THE RESULTS OF OTHER MOSTLY GROUND-BASED PROJECTS BUT THERE IS A SIGNIFICANT GAP IN THE DETECTED POPULATION OF LOW-MASS PLANETS AT SEPARATIONS OF FEW-10 AU WHERE MOST DETECTION TECHNIQUES SUFFER A DRAMATIC DROP IN EFFICIENCY AND/OR SENSITIVITY. MICROLENSING OFFERS A WAY TO BRIDGE THIS GAP AND SO IS ONE OF THE GOALS OF THE FORTHCOMING WFIRST MISSION. PREPARATORY WORK FOR THE WFIRST MICROLENSING SURVEY IS ALREADY UNDERWAY. A MAJOR ELEMENT OF IT WILL BE TO DEVELOP TOOLS CAPABLE OF ANALYZING THE LARGE RESULTING DATASET AND DETECTING MICROLENSING EVENTS WITHIN WHILE CAREFULLY DISTINGUISHING BETWEEN FALSE POSITIVES AND SYSTEMATICS. THIS PRESENTS A NUMBER OF CHALLENGES SINCE THE ANALYSIS OF JUST ONE BINARY LENSING EVENT CAN BE COMPUTATIONALLY INTENSIVE AND THERE IS A MARKED SHORTAGE OF PEOPLE (~10) IN THE US WHO SPECIALIZE IN THIS SUBJECT. EXISTING SOFTWARE TOOLS FOR THIS TASK ARE MOSTLY PROPRIETARY AND HAVE LIMITATIONS WHICH MEAN THEY WILL NOT SCALE TO PROCESS THE WFIRST DATASET IN A TIMELY MANNER. WE WILL ADDRESS THIS CHALLENGE BY DEVELOPING A TWO-STAGE DETECTION AND CLASSIFICATION SYSTEM FOR THE WFIRST BULGE SURVEY DATA USING A COMBINATION OF MACHINE LEARNING TECHNIQUES. THE FIRST STAGE BUILDS ON PROTOTYPE RANDOM-FOREST MICROLENSING/VARIABLE STAR DETECTION SOFTWARE ALREADY DEVELOPED BY OUR TEAM TO DISTINGUISH ASTROPHYSICAL SIGNALS FROM SYSTEMATICS OR FALSE POSITIVE DETECTIONS. WE PROPOSE TO COMBINE THIS WITH A SECOND STAGE WHICH WILL LEVERAGE RECENT PROGRESS IN DEEP LEARNING SOFTWARE TO ANALYZE THE LIGHTCURVES OF BINARY LENSING EVENTS AND IDENTIFY ALL POSSIBLE MODELS WHICH ARE CONSISTENT WITH THE DATA. THIS WILL ADDRESS A LONG-STANDING PROBLEM IN THE MODELING OF BINARY LENSES FOR WHICH THERE ARE A NUMBER OF KNOWN DEGENERACIES. THE EFFECTIVENESS OF MACHINE LEARNING SYSTEMS DEPENDS CRITICALLY ON THE QUALITY AND QUANTITY OF THE DATA USED TO TRAIN THE SYSTEM. WE WILL TO LEVERAGE A NUMBER OF PUBLIC PHOTOMETRIC CATALOGS TO HELP TO TRAIN THE SYSTEM AND APPLY IT TO ANALYZE DATA FROM THE ONGOING MICROLENSING KEY PROJECT AT LCO ROME/REA A HIGH CADENCE TRI-BAND OPTICAL SURVEY FOR MICROLENSING EVENTS IN THE GALACTIC BULGE. OUR TEAM WAS AWARDED 2650 HRS/YR FOR 3YRS STARTING IN 2017 FOR THIS SURVEY WHICH IS CURRENTLY IN ITS SECOND OBSERVING SEASON. WE WILL RELEASE A COMPLETE CATALOG OF THE IMAGING AND PHOTOMETRY FROM ROME/REA FOR COMMUNITY USE THROUGH A NASA ARCHIVE. WE WILL ALSO CONDUCT SIMULATED-EVENT INJECTION TESTS TO EVALUATE THE ALGORITHM'S PERFORMANCE AND DETECTION STATISTICS. ONCE THE ALGORITHM IS APPLIED TO WFIRST DATA THIS ANALYSIS WILL ENABLE US TO CALCULATE THE TRUE PLANET FREQUENCY. ALL SOFTWARE DEVELOPED THROUGH THIS PROPOSAL WILL BE THOROUGHLY TESTED AND DOCUMENTED AHEAD OF ITS PUBLIC RELEASE FOR COMMUNITY USE. THIS PROPOSAL IS HIGHLY RESPONSIVE TO THE AIMS OF THE EXOPLANETS RESEARCH PROGRAM SINCE IT WILL DISCOVER AND CHARACTERIZE PLANETARY SYSTEMS AND ADVANCE PREPARATIONS FOR THE WFIRST MISSION. IT WILL ALSO PROVIDE A VALUABLE RESOURCE FOR A WEALTH OF STELLAR ASTROPHYSICS.

THE PURPOSE IS TO REACH, EDUCATE, AND SUPPORT HISTORICALLY UNDERSERVED PRODUCERS, INCLUDING SOCIALLY DISADVANTAGED, LIMITED RESOURCE, AND BEGINNING FARMERS IN LA, MO, AND MS.

TAS::89 0309::TAS MODERNIZATION OF INSTRUMENTATION AT NINE GLOBAL SEISMOGRAPHIC NETWORK (GSN) STATIONS CONTRACT SPECIALIST - LUANN GADBERRY, PH: 50

COLLABORATIVE RESEARCH: SZ4D CATALYST -DESPITE THE GLOBAL URGENCY TO MITIGATE THE RISK FROM GEOHAZARDS, WE STILL HAVE LIMITED UNDERSTANDING OF THE FUNDAMENTAL DRIVERS BEHIND EARTHQUAKES, TSUNAMIS, VOLCANIC ERUPTIONS, AND LANDSLIDES, AND THUS THEIR PREDICTABILITY IN TIME AND SPACE. THE SZ4D (SUBDUCTION ZONES IN FOUR DIMENSIONS) INITIATIVE IS A COMMUNITY-DRIVEN EFFORT THAT STRIVES TO ADDRESS THIS NEED DIRECTLY BY COORDINATING AND ENABLING FUNDAMENTAL RESEARCH ON THE UNDERLYING PHYSICAL AND CHEMICAL CHARACTERISTICS AND PROCESSES SPECIFICALLY IN SUBDUCTION ZONES. SZ4D SEEKS TO ANSWER THE FOLLOWING QUESTIONS: WHEN AND WHERE DO LARGE DAMAGING EARTHQUAKES HAPPEN? HOW DO TRANS-CRUSTAL PROCESSES INITIATE ERUPTIONS AT ARC VOLCANOES? HOW DO EVENTS WITHIN EARTH?S ATMOSPHERE, HYDROSPHERE, AND SOLID EARTH GENERATE AND TRANSPORT SEDIMENT ACROSS SUBDUCTION ZONE LANDSCAPES AND SEASCAPES? WHAT FRACTION OF A SUBDUCTION ZONE?S ENERGY BUDGET GOES INTO BUILDING AND SHAPING SUBDUCTION ZONE LAND- AND SEASCAPES? HOW CAN WE TRANSFORM THE MINDSET OF OUR GEOSCIENCE COMMUNITY TO EMBRACE EDUCATION, OUTREACH, ACCESSIBILITY, CAPACITY BUILDING, DIVERSITY, EQUITY, INCLUSION, AND SOCIAL JUSTICE AS CRITICAL COMPONENTS FOR THE SUCCESS OF THE SZ4D AND FUTURE SCIENTIFIC ENDEAVORS BY THE GEOSCIENCES COMMUNITY? ANSWERING THESE QUESTIONS WILL REQUIRE A SUBSTANTIAL INFRASTRUCTURE INVESTMENT IN THE FORM OF INSTRUMENTAL ARRAYS ACCOMPANIED BY SUPPORT FOR FIELD, MODELING AND LABORATORY SCIENCE. THE EXPANSIVE VISION OF SZ4D NEEDS COST ESTIMATES, TIME PHASING AND PROJECT PLANNING IN ORDER TO PREPARE FOR FULL SUBMISSION TO THE FOUNDATION AND ANY PARTNERING AGENCIES. THIS PROPOSAL LAYS OUT A PLAN TO ACCOMPLISH THIS DEVELOPMENT QUICKLY. THE MAJOR COMPONENTS OF THIS PROPOSED SZ4D CATALYST EFFORT ARE: 1) A STAFFED CENTER THAT WILL ORGANIZE THE WORK AND BUILD EQUITY AND CAPACITY IN THE GEOSCIENCES (BECG) FOLLOWING A COLLECTIVE IMPACT MODEL. 2) TECHNICAL PROJECT MANAGEMENT TO REALISTICALLY EVALUATE COSTS AND TRADE-OFFS OF THE INSTRUMENTATION OPTIONS. 3) PREPARATORY WORK FOR THE GEOLOGICAL, MODELING AND LABORATORY FACILITIES WHICH INCLUDE WORKSHOPS AND MODEST ENGINEERING DESIGN WORK. ALL OF THESE SPECIFIC ACTIVITIES WERE STRATEGICALLY SELECTED BECAUSE THEY DIRECTLY AFFECT HIGH-PRIORITY ELEMENTS OF THE DRAFT IMPLEMENTATION PLAN AND HAVE IDENTIFIABLE, TRACTABLE DEVELOPMENT NEEDS THAT SHOULD BE ADDRESSED PRIOR TO LAUNCH OF A FULL SZ4D PROGRAM. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

KEPLER AND OTHER EXOPLANET SURVEYS HAVE OPENED A WINDOW INTO OUR GALAXY S POPULATION OF WARM EXOPLANETS WITH ORBITAL SEPARATIONS OUT TO ~1AU. TO PICK

DEVELOPMENT OF PERIVASCULAR SPACE MAPPING TOOLSET AS A DIAGNOSTIC AID FOR ALZHEIMER'S DISEASE - PROJECT SUMMARY ALZHEIMER’S DISEASE (AD) IS A DEVASTATING DISEASE THAT AFFECTS MILLIONS OF AMERICANS AND IMPOSES A HUGE SOCIO- ECONOMIC BURDEN. AD-RELATED COGNITIVE DECLINE IS ASSOCIATED WITH THE ACCUMULATION OF ASS (AMYLOID BETA) PLAQUES AND NEUROFIBRILLARY TANGLES OF HYPERPHOSPHORYLATED TAU PROTEIN, WHICH ARE INSUFFICIENTLY CLEARED AND DEGRADED BY MECHANISMS SUCH AS THE GLIA-LYMPHATIC SYSTEM OR BY TRANSPORT ACROSS THE BLOOD-BRAIN BARRIER (BBB). ANIMAL RESEARCH HAS SHOWN THAT THE GLIA-LYMPHATIC PATHWAY PLAYS A SUBSTANTIAL ROLE IN THE NET CLEARANCE OF ASS. IN ADDITION, REDUCTION OF INTERSTITIAL FLUID EFFLUX TO THE CEREBROSPINAL FLUID, OR REDUCTION OF TRANSPORT ACROSS THE BBB, COULD LESSEN THE ASS CLEARANCE. HUMAN MAGNETIC RESONANCE IMAGING (MRI) STUDIES HAVE ALSO SHOWN THAT THE INTEGRITY OF THE PERIVASCULAR SPACE (PVS), THE PATHWAY OF GLIA-LYMPHATIC SYSTEM, IS A MARKER OF GLIA-LYMPHATIC BRAIN HEALTH AND ITS ALTERATION IS AN IMPORTANT FEATURE OF AD PATHOLOGY. PVS ALTERATION IN AD HAS BEEN SHOWN TO BE INDEPENDENT OF AMYLOID UPTAKE, IMPLICATING ASTROGLIAL INVOLVEMENT SPECIFIC TO AD. INFORMATION ABOUT PVS INTEGRITY COULD ASSIST CLINICIANS WITH MAKING SPECIFIC DIAGNOSIS ABOUT PATIENTS AD STATUS AND MECHANISM. THEREFORE, A TOOL THAT ALLOWS NON-INVASIVE IN-VIVO MAPPING OF PVS FROM CLINICAL MRI IS OF HIGH SIGNIFICANCE TO AID AD DIAGNOSIS AND DISEASE MONITORING BUT DOES NOT YET EXIST. CURRENT CLINICAL ROUTINE TO INVESTIGATE PVS IS A RELATIVELY CRUDE APPROACH BASED ON COUNTING TOTAL NUMBER OF OBSERVED PVS IN MRI BY NEURO-RADIOLOGISTS, WHICH IS NON-SPECIFIC, RATER-DEPENDENT, AND DOES NOT CAPTURE THE DISTRIBUTION, WHOLE EXTENT OF PVS CHANGE NOR VOLUMETRIC FEATURES OF THE PVS. FROM A PRACTICAL POINT OF VIEW, THIS TECHNIQUE IS TIME CONSUMING AND LABORIOUS. THESE LIMITATIONS IN PART HAVE PREVENTED NEUROLOGISTS FROM ADOPTING PVS QUANTIFICATION INTO THEIR CLINICAL ROUTINE. WE HAVE DEVELOPED COMPUTATIONAL TECHNIQUES FOR MAPPING AND QUANTIFYING PVS MORPHOLOGY FROM MRI, WHICH ENABLES AUTOMATED AND ACCURATE QUANTIFICATION OF PVS ACROSS THE BRAIN WITHOUT THE NEED FOR TIME CONSUMING MANUAL INTERVENTION. THESE TECHNIQUES WERE DEVELOPED ON RESEARCH DATA, WHICH HAD SLIGHTLY HIGHER RESOLUTION THAN CLINICAL MRI. THE GOAL OF THIS PROPOSAL IS TO VALIDATE AND OPTIMIZE THIS TECHNOLOGY ON CLINICAL MRI DATA, WHICH CAN BE VARIABLE IN QUALITY AND RESOLUTION. WE ALSO AIM TO DEVELOP A SCANNER- AND HARDWARE-AGNOSTIC DEPLOYABLE ANALYTICAL SOLUTION FOR AUTOMATED PVS QUANTIFICATION, SO THAT PVS MAPPING CAN BE PERFORMED INDEPENDENT OF THE RADIOLOGY/IMAGING IT INFRASTRUCTURE. IF SUCCESSFUL, WE WILL HAVE A FULLY DEVELOPED AND VALIDATED BACKEND SOFTWARE THAT ENABLES AUTOMATED ASSESSMENT OF PVS AND AIDS SPECIFIC AD DIAGNOSIS AND DISEASE MONITORING. UPON THE COMPLETION OF THIS GOAL, OUR PHASE II WILL FOCUS ON TRANSLATION OF THE TECHNOLOGY VIA IMPLEMENTATION AND TESTING OF THE TECHNOLOGY IN COLLABORATION WITH OUR STRATEGIC PARTNERS IN CLINIC (NEURORADIOLOGY DIVISION OF KECK SCHOOL OF MEDICINE), INDUSTRY (BIOGEN INC.) AND RESEARCH (MARKVCID AND NASA). OUR ULTIMATE GOAL WILL BE TO INTEGRATE PVS MEASURES INTO CLINICAL DIAGNOSIS, DISEASE MONITORING AND INTERVENTION EFFICACY ASSESSMENT, AS A SPECIFIC NON-INVASIVE AND IN-VIVO IMAGING MARKER OF AD PATHOLOGY THAT CAN BE AUTOMATICALLY AND RELIABLY MEASURED.

USA SKY PARTNERS: EXPANDING ACCESS TO AUTHENTIC RESEARCH EXPERIENCES FOR UNDERGRADUATES -A PROGRAM CALLED USA SKY PARTNERS, MANAGED BY THE LAS CUMBRES OBSERVATORY (LCO), WILL PROVIDE ASTRONOMY RESEARCH OPPORTUNITIES FOR STUDENTS AT US UNDERGRADUATE INSTITUTIONS, ESPECIALLY THOSE WHO ARE HISTORICALLY UNDERREPRESENTED IN ASTRONOMY AND WHO DO NOT HAVE EASY ACCESS TO PROFESSIONAL ASTRONOMICAL FACILITIES. THE PROGRAM PROVIDES THE CURRICULUM MATERIALS, TRAINING AND MENTORING FOR FACULTY, AND ACCESS TO A PROFESSIONAL TELESCOPE NETWORK. THE PROGRAM BUILDS RESEARCH CAPACITY, AND FOSTERS A DIVERSE, INCLUSIVE, AND EQUITABLE ENVIRONMENT FOR RESEARCH AND EDUCATION. OVER THE NEXT THREE YEARS, THE PROJECT WILL GROW THE PROGRAM DEVELOPED DURING A TWO-YEAR PILOT PHASE TO ADD UP TO 25 FACULTY MEMBERS PARTICIPATING AT CAMPUSES ON THE US MAINLAND AND IN PUERTO RICO. THE USA SKY PARTNERS RESEARCH EXPERIENCE TO ENGAGE STUDENTS IS CALLED THE ASTRONOMY RESEARCH SEMINAR. THE FIRST SEMINAR TOPIC FOR THE PROGRAM IS DOUBLE STAR ASTROMETRY. THE 8-WEEK RESEARCH PROGRAM CAN BE DONE SEPARATELY OR IN CONJUNCTION WITH AN INTRODUCTORY ASTRONOMY COURSE. THE CURRICULUM MATERIALS ARE ALL AVAILABLE ONLINE. THE OBSERVING EXPERIENCE UTILIZES THE TEN 0.4M TELESCOPES IN THE LCO GLOBAL ROBOTIC TELESCOPE NETWORK. THESE TELESCOPES ARE DEDICATED ALMOST ENTIRELY TO EDUCATION. ALL THAT IS REQUIRED TO OBSERVE WITH LCO TELESCOPES IS A COMPUTER WITH ACCESS TO THE INTERNET AND AN ALLOCATION OF TELESCOPE TIME, WHICH IS PROVIDED THROUGH THIS AWARD. THE MATERIALS ARE OPEN SOURCE AND PROVIDED IN ENGLISH AND SPANISH, THUS EXPANDING ACCESS. A KEY COMPONENT OF THE PROGRAM IS TO PROVIDE A FRAMEWORK FOR DEVELOPING PARTNERSHIPS BETWEEN INTERESTED INSTITUTIONS TO SHARE MATERIALS AND OTHER SUCCESSFUL INTERNAL PROGRAMS. THESE INTERACTIONS HELP BUILD A MORE DIVERSE AND INCLUSIVE COMMUNITY. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

DEVELOPMENT OF A PRE-OPTICS MODULE FOR SPECTROSCOPIC WAVELENGTH SPLITTING AND PUPIL SLICING -THIS PROJECT SEEKS TO DEVELOP A NEW TOOL FOR ASTRONOMERS TO STUDY THE SPECTRUM OF LIGHT FROM OBJECTS IN SPACE. SPECTROSCOPY ALLOWS SCIENTISTS TO DETERMINE CHARACTERISTICS OF AN OBJECT -- SUCH AS TEMPERATURE, DISTANCE, AND MOTION -- AND POTENTIALLY TO DISCOVER DISTANT EXOPLANETS. CURRENT TECHNOLOGY USES FIBER OPTIC CABLES TO FEED LIGHT INTO SPECTROGRAPHS. EXISTING SPECTROGRAPHS ARE LARGE, COMPLICATED INSTRUMENTS. THE PRINCIPAL INVESTIGATOR WILL DEVELOP NEW TECHNOLOGY THAT WILL MAKE SPECTROGRAPHS CAN BE SMALLER, MORE EFFICIENT, AND LESS COSTLY. HE WILL ALSO EXPLORE USING A SPECIAL SURFACE TREATMENT ON THE LENSES TO REDUCE UNWANTED REFLECTIONS. THESE TECHNOLOGICAL ADVANCEMENTS WILL BENEFIT NOT ONLY ASTRONOMY, BUT ALSO AND OTHER APPLICATIONS OF SPECTROSCOPY. THE COMMUNITY OUTREACH INITIATIVES WILL ENGAGE STUDENTS AND PROMOTE STEM ACTIVITIES RELATED TO THE PROJECT'S OBJECTIVES. THIS STUDY WILL ADVANCE A CONCEPT FOR SEPARATING THE WAVELENGTH CHANNELS OF A SPECTROGRAPH INTO SIMPLER AND SMALLER SPECTROGRAPHS THAT WOULD ALLOW MORE COMPACT INSTRUMENTS. THIS IS USEFUL FOR MASSIVELY MULTIPLEXED SPECTROSCOPIC FACILITIES, WHERE THE NUMBER OF SPECTROGRAPHS IS QUITE LARGE AND SPACE TO LOCATE THE SPECTROGRAPHS LIMITED. SUCH WAVELENGTH SPLITTING IN A PRE-OPTICS MODULE RATHER THAN IN THE SPECTROGRAPH REDUCES THE SIZE AND RISK ASSOCIATED WITH WAVELENGTH BEAM SPLITTERS. IT ALSO ALLOWS FOR LOCATING BLUE CHANNELS CLOSER TO THE TELESCOPE TO SIGNIFICANTLY IMPROVE THE TRANSMITTED LIGHT SHORTWARD OF 500 NM. ADDITIONALLY, THE STUDY WILL EXPLORE THE USE OF NANOSTRUCTURES FOR ANTIREFLECTION PURPOSES AND INVESTIGATE MASS PRODUCTION TECHNIQUES FOR FUTURE SCALABILITY. THESE UNITS ALSO ALLOW THE IMPLEMENTATION OF PUPIL SLICING, WHICH CAN FURTHER SIMPLIFY SPECTROGRAPH COMPLEXITY. THE PROJECT'S INTELLECTUAL MERIT LIES IN ADVANCING THE DESIGN ASPECTS OF WAVELENGTH SPLITTING AND PUPIL SLICING, BENEFITING THE FIELD OF ASTRONOMICAL SPECTROSCOPY AND OTHER SPECTROSCOPIC APPLICATIONS. FURTHERMORE, COMMUNITY OUTREACH INITIATIVES WILL ENGAGE STUDENTS AND PROMOTE STEM ACTIVITIES RELATED TO THE PROJECT'S OBJECTIVES. THIS PROJECT IS JOINTLY FUNDED BY THE DIVISION OF ASTRONOMICAL SCIENCES IN MPS AND THE ESTABLISHED PROGRAM TO STIMULATE COMPETITIVE RESEARCH (EPSCOR). THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

NANOPARTICLE GENERATOR FOR ANIMAL INHALATION EXPERIMENTS

COLLABORATIVE RESEARCH: NEAR-TRENCH COMMUNITY GEODETIC EXPERIMENT -COLLABORATIVE RESEARCH: NEAR-TRENCH COMMUNITY GEODETIC EXPERIMENT THE LARGEST EARTHQUAKES (AND THE RESULTING TSUNAMIS) OCCUR OFFSHORE, BUT THE INSTRUMENTS TRADITIONALLY USED TO STUDY THE GROUND DEFORMATION ASSOCIATED WITH THESE EVENTS CAN ONLY BE USED ON LAND. THEREFORE, TRADITIONAL SURVEYING CANNOT QUANTIFY THE OFFSHORE SEISMIC HAZARDS. STUDYING THESE HAZARDS REQUIRES TOOLS DESIGNED TO COLLECT DATA OFFSHORE. ONE SUCH TOOL IS THE GNSS-ACOUSTIC METHOD, AN OFFSHORE GPS (GLOBAL POSITIONING SYSTEM) METHOD WITH SETS OF INSTRUMENTS SET UP ON THE SEAFLOOR IN CIRCULAR GROUPINGS. THESE INSTRUMENTS ARE POSITIONED RELATIVE TO A REMOTE-CONTROLLED SEA SURFACE ROBOT USING SOUND PULSES. THIS ?WAVE GLIDER? CAN USE GPS TO DETERMINE ITS POSITION, ALLOWING THE SEAFLOOR INSTRUMENTS TO BE LOCATED WITH CM-LEVEL ACCURACY. TRACKING THESE POSITIONS OVER TIME ALLOWS RESEARCHERS TO LEARN HOW THE DEFORMING SEAFLOOR BUILDS UP STRESS THAT ULTIMATELY RESULTS IN EARTHQUAKES. THIS PROJECT FOLLOWS RECOMMENDATIONS BY A LARGE GROUP OF SCIENTISTS WHO ARE INTERESTED IN KNOWING HOW SEAFLOOR DEFORMS IN SUBDUCTION ZONES AS THE SEAFLOOR CRUST GRADUALLY SLIDES BENEATH THE CONTINENTAL CRUST. THE PROJECT AIMS TO DETECT THE MOTIONS OF THE SEAFLOOR AT SIX STATIONS IN THE OFFSHORE CASCADIA REGION AND SIX IN THE OFFSHORE ALASKA REGION. THIS WILL AID THE SCIENTIFIC COMMUNITY IN ASSESSING THE SEISMIC AND TSUNAMI HAZARDS IN THESE REGIONS. THE DATA WILL ALL BE OPEN ACCESS AND THE PROJECT WILL CONTRIBUTE TO TRAINING THE NEXT GENERATION OF GEODETIC SCIENTISTS. THE 2011 TOHOKU EARTHQUAKE DEMONSTRATED THAT COSEISMIC RUPTURE CAN EXTEND TO SHALLOW DEPTHS ALONG A SUBDUCTION MEGATHRUST, WHERE LARGE VERTICAL DISPLACEMENTS OF THE SEAFLOOR CAN GENERATE DAMAGING TSUNAMIS. THIS PROJECT WILL CLARIFY WHETHER A SIMILAR EVENT CAN HAPPEN IN THE OFFSHORE CASCADIA AND ALASKA REGIONS BY USING SEAFLOOR GEODETIC OBSERVATIONS TO INFER THE LEVEL OF ELASTIC STRAIN STORED IN THE ACCRETIONARY PRISMS OF CASCADIA AND ALASKA SUBDUCTION ZONES. THE RESEARCHERS WILL DEPLOY GNSS-ACOUSTIC INSTRUMENTS FROM THE SEAFLOOR GEODESY COMMUNITY POOL, WHICH CONSISTS OF 51 GNSS-ACOUSTIC TRANSPONDERS (ENOUGH FOR 17 NEW GNSS-ACOUSTIC SITES) AND 3 WAVE GLIDERS, FOLLOWING RECOMMENDATIONS FROM 165 SCIENTISTS AND STUDENTS WHO ATTENDED A SEAFLOOR GEODESY COMMUNITY WORKSHOP ON HOW BEST TO MAKE USE OF THE INSTRUMENT POOL. TWELVE NEW GNSS-ACOUSTIC SITES WILL BE ESTABLISHED DURING THIS EXPERIMENT, WITH SIX ALONG EACH OF THE CASCADIA AND ALASKA SUBDUCTION ZONE TRENCHES, WHICH WERE IDENTIFIED BY WORKSHOP ATTENDEES AS HIGH-VALUE SCIENCE TARGETS. THE RESEARCHERS WILL SURVEY THESE NEW SITES AS WELL AS THE SEVEN SITES ALREADY ESTABLISHED IN THESE REGIONS ANNUALLY THROUGHOUT THE FIVE YEARS OF THE PROJECT. THESE POSITIONS WILL BE USED TO INFER INTERSEISMIC VELOCITIES FROM WHICH THE RATE OF ELASTIC STRAIN BUILDUP IN THE ACCRETIONARY PRISMS CAN BE DETERMINED, WITH IMPLICATIONS FOR THE EARTHQUAKE AND TSUNAMI HAZARD IN ALASKA AND THE PACIFIC NORTHWEST. THE DATA WILL ALL BE OPEN ACCESS AND THE PROJECT WILL CONTRIBUTE TO TRAINING THE NEXT GENERATION OF GEODETIC SCIENTISTS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

UNDERGRADUATE SUMMER RESEARCH IN SEISMOLOGY - REU SITE

A BREAKTHROUGH MOBILE PHONE TECHNOLOGY THAT AIDS IN EARLY DETECTION OF COPD - PROJECT SUMMARY / ABSTRACT COPD IS THE FOURTH LEADING GLOBAL KILLER, IN PART, BECAUSE OF THE FAILURE OF FRONTLINE MEDICINE TO DETECT THE DISEASE. POOR EARLY DETECTION LEADS TO UNFAVORABLE OUTCOMES AND HIGH HEALTHCARE COSTS. TELE-STETHOSCOPE* OR “TS” IS NOVEL TECHNOLOGY THAT ALLOWS ACOUSTIC DATA CAPTURED FROM ORDINARY MOBILE PHONES TO PERFORM ROBUST ANALYSIS OF HEMODYNAMICS AND PNEUMODYNAMICS. TS IS INTENDED TO BE USED IN PRIMARY CARE PARTICULARLY IN TELE-HEALTH AND BEFORE SCHEDULED PHYSICAL EXAMINATION. ITS PURPOSE IS TO ALERT PRIMARY CARE PHYSICIANS TO THE NEED FOR PHYSICAL EXAMINATION AND POSSIBLY REFERRAL. IN THESE SITUATIONS, THERE ARE NO OTHER COMPARABLE TESTING OPTIONS. TS HAS THREE IMPORTANT INNOVATIONS. FIRST, IS A CLINICAL USE INNOVATION WHICH BRINGS REMOTE, IMPROMPTU PATIENT EVALUATION TO ANYONE WITH A SMARTPHONE. CUSTOMER DISCOVERY HAS VALIDATED BOTH A WORKFLOW AND REIMBURSEMENT STRATEGY CONSISTENT WITH COMMERCIAL SUCCESS. FURTHER, FDA GUIDANCE SUGGESTS VIABILITY OF AGENCY CLEARANCE. SECOND IS TS’S NOVEL APPROACH TO MAKING AI ALGORITHMS. TS USES ACOUSTIC DATA, CAPTURED BY OEM PHONE MICROPHONES, INTO RIGOROUS, PHYSICS-BASED FEATURES THAT DESCRIBE ORGAN HEMODYNAMICS AND PNEUMODYNAMICS. THE FEATURES OR INDEPENDENT VARIABLES ARE THEN USED TO CREATE BINARY CLASSIFICATION MODELS WITH LOGISTIC REGRESSION. BY RELYING ON PHYSICS, TS NEVER HAS TO USE NEURAL NETWORKS OR OVERFITTING STRATEGIES THAT HAVE RAISED CONCERNS ABOUT DATA INTENSITY, MODEL STABILITY, REGULATORY TRANSPARENCY AND UNKNOWN RELIABILITY. THE THIRD INNOVATION IS THAT, BY RELYING ON PASSIVE ACOUSTIC DATA, TS CLASSIFIES ORGAN FUNCTION BY OBSERVING ORGAN DYNAMICS DIRECTLY RATHER THAN FROM FORCED AIR CAPACITY. TS USES MANY IDEAS FROM PHYSICS THAT WERE NOT AVAILABLE UNTIL FAIRLY RECENTLY. BY RELYING ON DYNAMICS, TS OFFERS A NOVEL APPROACH TO FORCED AIR THAT MAY EVENTUALLY BE ADDITIVE TO OUR UNDERSTANDING OF RESPIRATORY CONDITIONS EVEN IN PFT LABS. THIS WILL BE THE THIRD LARGE SCALE HUMAN STUDY THAT DEMONSTRATES CLASSIFICATION OF CARDIO - PULMONARY FUNCTIONALITY. IT FOLLOWS A PUBLISHED STUDY ON COVID DETECTION AS WELL AS SOON TO BE PUBLISHED STUDY ON THE ABILITY OF TS TO REPRODUCE ECHOCARDIOGRAM ESTIMATES OF EJECTION FRACTION. ANALYSIS OF STETHOSCOPE RECORDINGS SUGGESTS THAT THE COPD DIAGNOSTIC WILL RELY ON A COMBINATION OF RIGHT HEART SIDE HEMODYNAMICS AND LOW FREQUENCY LUNG PNEUMODYNAMICS. A SIGNIFICANT BODY OF RESEARCH IS PRESENTED WHICH VALIDATES THE USE OF MOBILE PHONES AS AN AUSCULTATION DEVICE WITH THE ABILITY TO DETECT AND DIAGNOSIS COPD. THE AIM OF THIS STUDY IS TO DEVELOP, EVALUATE, AND TEST AN ALGORITHM THAT ALLOWS ORDINARY MOBILE PHONES TO DETECT COPD. OUR HYPOTHESIS IS THAT TS TECHNOLOGY CAN DETECT COPD BY MATCHING PHONE ACOUSTIC RECORDINGS TO DIAGNOSIS. DIAGNOSIS WILL BE DETERMINED BY A PHYSICIAN AFTER CONSIDERING GOLD STANDARD TESTING. PERFORMANCE OF THE MODELS WILL BE EVALUATED BY USING COMMON STATISTICAL APPROACHES SUCH AS AREA UNDER THE RECEIVER OPERATING CURVE AUC, SENSITIVITY, SPECIFICITY, ACCURACY. THE RESEARCH WILL HAVE 3 MILESTONES BASED ON RECRUITMENT OF 30, 60 AND 100 PATIENTS RESPECTIVELY. OUR APPROACH IS BASED ON RECRUITMENT FROM PATIENTS ASSIGNED TO A HOSPITAL PFT LAB SO THAT RECORDINGS AND GOLD STANDARD TESTING ARE DONE CONCURRENTLY. OUR TEAM CONSISTS OF A BROAD RANGE OF TALENT INCLUDING THE INVENTOR OF TS, PULMONOLOGY EXPERTISE, THE RESEARCH DIRECTOR OF EMERGENCY MEDICINE FOR THE HOSPITAL RUNNING THE TESTS, STATISTICAL EXPERTISE, AND PROJECT MANAGEMENT. * TELE-STETHOSCOPE OR "TS" IS PATENT PENDING TECHNOLOGY DEVELOPED BY FLEMING SCIENTIFIC.

FEASIBILITY OF APP-DELIVERED CIRCADIAN SYNCHRONIZATION THERAPY WITH LIGHT IN A COHORT OF PREGNANT WOMEN - PROJECT SUMMARY CIRCADIAN RHYTHMS PLAY A VITAL ROLE IN PROMOTING MATERNAL HEALTH AND MANAGING PREGNANCY OUTCOMES, INCLUDING GESTATIONAL DIABETES, PRETERM BIRTH, AND POSTPARTUM DEPRESSION. HOWEVER, INTERVENTIONS TO MITIGATE CIRCADIAN RHYTHMS DISRUPTION DURING PREGNANCY ARE LACKING, DESPITE READILY AVAILABLE NON-PHARMACOLOGICAL CIRCADIAN INTERVENTIONS. THE CIRCADIAN TIMEKEEPING SYSTEM IS STRENGTHENED AND ALIGNED TO THE 24-HOUR DAY BY LIGHT, AND ENVIRONMENTAL LIGHT MANIPULATIONS CAN SHIFT THE PHASE AND ALTER THE AMPLITUDE OF CIRCADIAN RHYTHMS WHEN BASED ON CAREFUL TIMING AND COMBINED WITH OTHER BEHAVIORS. THIS PHASE I STTR PROJECT AIMS TO EVALUATE THE FEASIBILITY OF CIRCADIAN SYNCHRONIZATION THERAPY WITH LIGHT (CST-L) IN A SOCIOECONOMICALLY DIVERSE POPULATION OF PREGNANT WOMEN. THE INTERVENTION INVOLVES BRIGHT LIGHT EXPOSURE AT SPECIFIC TIMES TO PHASE ADVANCE, DELAY, OR BOOST THE AMPLITUDE OF THE CIRCADIAN CLOCK, DIM LIGHT AT OTHER TIMES, AS WELL AS THE USE OF A DIARY TO TRACK THE CAUSES OF CIRCADIAN DISRUPTION. TO EVALUATE THE SUCCESS OF THE TRIAL, WE WILL COLLECT SUBJECTIVE FEEDBACK FROM 20 PREGNANT WOMEN USING THE APP AND BLUE-BLOCKING GLASSES FOR FOUR WEEKS, AND WILL MAKE ITERATIVE UPDATES TO THE APP IN RESPONSE TO USER FEEDBACK. THE ULTIMATE GOAL IS TO DEVELOP A MOBILE APPLICATION FOR BOTH IOS AND ANDROID THAT DELIVERS CST-L AND HELPS IMPROVE MATERNAL MOOD AND HEALTH, AS WELL AS INFANT SLEEP TRAINING. IF SUCCESSFUL, THIS INTERVENTION COULD HELP REDUCE THE RISK OF PRETERM BIRTH, POSTPARTUM DEPRESSION, AND OTHER POOR OUTCOMES DURING AND AFTER PREGNANCY.

A NOVEL MOBILE PHONE TECHNOLOGY TO IMPROVE ACCESS FOR PREECLAMPSIA AND HYPERTENSION DETECTION - PROJECT SUMMARY / ABSTRACT PREECLAMPSIA IS A COMPLICATION AFFECTING 2 – 8% OF ALL PREGNANCIES AND RESULTS IN SIGNIFICANT MATERNAL AND NEONATAL MORBIDITY AND MORTALITY. THE INVENTION TO BE RESEARCHED IN THIS GRANT DETECTS PREECLAMPSIA AND HYPERTENSION IN PATIENTS WITH THE PHONES THAT THEY ALREADY OWN. IT IMPROVES OUTCOMES BY INCREASING ACCESS TO CARE AMONG UNDERSERVED POPULATIONS AND MONITORING FREQUENCY AMONG HIGH RISK PATIENTS. PATIENTS RECORD THEMSELVES USING THEIR OWN PHONES WHICH TAKES ONLY A FEW MINUTES. THE LONG TERM OBJECTIVE IS TO COMMERCIALIZE A PRODUCT WHICH ENABLES ANY OF 7 BILLION PHONES TO ASSIST IN PREECLAMPSIA OR GESTATIONAL HYPERTENSION DETECTION. THE INVENTION IS INTENDED TO BE USED AT HOME BY PATIENTS VIA A PHONE APP WITH RESULTS SENT TO THE PRESCRIBING OBSTETRICIAN (OB). THE PURPOSE IS TO ALERT THE OB IF IMMEDIATE PHYSICAL EXAMINATION IS NEEDED AND TO INITIATE POSSIBLE PREECLAMPSIA MANAGEMENT PROTOCOL. IN THESE SITUATIONS, THERE ARE NO OTHER COMPARABLE TESTING OPTIONS. THE INVENTION INCLUDES BOTH IMPROVEMENTS TO CLINICAL PRACTICE AND TO SCIENCE. CURRENT CLINICAL PRACTICE STANDARD OF CARE REQUIRES PATIENTS TO BE EXAMINED IN AN OB OFFICE. THE INVENTION ALLOWS PREECLAMPSIA AND HYPERTENSION TO BE DETECTED VIA PATIENT SELF-EXAMINATION FROM LOCATIONS OUTSIDE THE OB OFFICE. THIS IMPROVES UPON CURRENT TECHNOLOGY SUCH AS HOME BLOOD PRESSURE CUFFS AND IN-OFFICE DIPSTICK URINALYSIS. IN TERMS OF IMPROVEMENTS TO SCIENCE, THE INVENTION CONSISTS OF BOTH A UNIVERSAL TRANSLATOR (UT) AND DEDUCTIVE INTELLIGENCE (DI). UT ALLOWS FOR ANY MOBILE PHONE TO CAPTURE BODY ACOUSTIC DATA. DI IS A NOVEL PHYSICS BASED APPROACH TO CREATING CLASSIFIER ALGORITHMS FROM PASSIVELY RECEIVED TIME SERIES DATA, SUCH AS MOBILE PHONE RECORDINGS RECEIVED FROM THE UT. THE INVENTION ANALYZES HEMODYNAMICS AND EXTRACTS PERTINENT PHYSICS BASED FEATURES FROM WHICH A CLASSIFIER ALGORITHM IS BASED. THIS WILL BE THE THIRD LARGE SCALE HUMAN STUDY THAT DEMONSTRATES CLASSIFICATION OF CARDIO - PULMONARY FUNCTIONALITY. IT FOLLOWS A PUBLISHED STUDY ON COVID DETECTION AS WELL AS A STUDY UNDER PEER REVIEW ON THE ABILITY TO REPRODUCE ECHOCARDIOGRAM ESTIMATES OF EJECTION FRACTION. THE ECHOCARDIOGRAM STUDY ESTABLISHES THE PROTOCOL TO BE USED IN THE PROPOSED RESEARCH. IN A RECENT PRELIMINARY STUDY, 46 PREGNANT WOMEN WERE RECORDED AT THE AORTIC SITE. THE RESULTING MODEL WAS ABLE TO DETERMINE WHICH PATIENTS HAD HIGH BLOOD PRESSURE AND TO ACCURATELY DETERMINE WHICH PATIENTS HAD COMPLICATIONS. THESE STUDIES SUPPORT OUR HYPOTHESIS THAT ACOUSTIC HEMODYNAMIC DATA CAPTURED BY OEM PHONE MICROPHONES, AT THE AORTIC AUSCULTATION SITE AND AT THE UPPER ARM, CAN BE USED TO IDENTIFY PATIENTS WHO HAVE PREECLAMPSIA AND/OR HYPERTENSION. THE STUDY HAS TWO PRIMARY AIMS. THE FIRST IS TO DEMONSTRATE PROOF OF CONCEPT THAT THE INVENTION ENABLES ORDINARY MOBILE PHONES TO REPRODUCE PHYSICIANS’ DIAGNOSIS OF PRE-ECLAMPSIA. THE SECOND AIM IS TO DEMONSTRATE PROOF OF CONCEPT THAT THE INVENTION ENABLES ORDINARY MOBILE PHONES TO REPRODUCE CUFF MEASUREMENTS OF BLOOD PRESSURE AND TO DETECT HYPERTENSION. THE APPROACH IS BASED ON RECRUITMENT FROM BOTH OUTPATIENT CLINICS AND INPATIENT HOSPITAL SETTINGS. PATIENTS ALREADY LABELED WITH PREECLAMPSIA OR HIGH BLOOD PRESSURE WILL BE ENROLLED AS WELL AS CONTROL PATIENTS WITHOUT DISEASE CONDITIONS. PATIENTS WILL BE RECORDED BY CLINICIANS WITH A CUSTOM PHONE APP. ALGORITHMS WILL BE DEVELOPED BASED ON THESE RECORDINGS USING UT AND DI. RESULTS WILL BE TESTED AND ANALYZED USING AUC, SENSITIVITY/SPECIFICITY, ACCURACY AS WELL ADJ RSQ FOR THE LINEAR REGRESSION ANALYSIS. THE TEAM CONSISTS OF A BROAD RANGE OF TALENT INCLUDING THE INVENTOR OF THE TECHNOLOGY, THE MATERNAL FETAL MEDICINE DIVISION DIRECTOR AT THE HOSPITAL, THE RESEARCH DIRECTOR OF EMERGENCY MEDICINE FOR THE HOSPITAL RUNNING THE TESTS, STATISTICAL EXPERTISE, AND PROJECT MANAGEMENT.

PRODUCTION AND DEPLOYMENT OF ENVIRONMENT-CONTROLLED ENCLOSURES FOR THE NETWORK OF ROBOTIC ECHELLE SPECTROGRAPHS

SIGNALS: UNVEILING STAR-FORMING REGIONS IN NEARBY GALAXIES

FEASIBILITY OF A MOBILE APPLICATION FOR SLEEP AND CIRCADIAN RHYTHMS IN PEDIATRIC PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA AND THEIR CAREGIVERS - ABSTRACT LONG-TERM SURVIVAL RATES FOR CHILDREN DIAGNOSED WITH ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) CURRENTLY EXCEED 90%. HOWEVER, PROLONGED ALL CHEMOTHERAPY, WHICH LASTS TWO TO THREE YEARS ON AVERAGE, IS ASSOCIATED WITH SIGNIFICANT FATIGUE AND SLEEP DISTURBANCES IN BOTH CHILDREN AND THEIR CAREGIVERS. IN FACT, PATIENTS AND CAREGIVERS OFTEN IDENTIFY EXCESS FATIGUE AND SLEEP DISTURBANCES AS THE MOST DISTRESSING SYMPTOMS EXPERIENCED DURING ALL TREATMENT. IN ADDITION TO ADVERSELY IMPACTING QUALITY OF LIFE DURING TREATMENT, FATIGUE AND SLEEP PROBLEMS MAY ALTER MOOD, RESULT IN LONG-TERM COGNITIVE DYSFUNCTION, AND POTENTIALLY COMPROMISE TREATMENT EFFICACY. DESPITE UNFAVORABLE FATIGUE AND SLEEP BEING A PERVASIVE PROBLEM IN CHILDREN WITH ALL AND THEIR CAREGIVERS, EFFECTIVE INTERVENTION OPTIONS ARE LIMITED. THEREFORE, THERE IS A SIGNIFICANT UNMET CLINICAL NEED TO IDENTIFY EVIDENCE-BASED, MINIMALLY INVASIVE STRATEGIES TO INTERVENE AND RESTORE CIRCADIAN RHYTHMICITY IN PEDIATRIC PATIENTS WITH ALL AND THEIR CAREGIVERS. BUILDING UPON OUR PREVIOUS SUCCESS DEVELOPING MOBILE APPLICATIONS TO ADDRESS CANCER-RELATED FATIGUE IN ADULT ONCOLOGY POPULATIONS, THIS PROPOSAL SEEKS TO ADAPT A PILOT MOBILE APPLICATION TO TRACK SLEEP AND CIRCADIAN RHYTHMS IN PATIENTS WITH ALL AND THEIR CAREGIVERS. WHILE MANY EXISTING RESOURCES PROVIDE INFORMATION ON THE IMPORTANCE OF SLEEP DURATION, FEW HIGHLIGHT THE ROLE OF CIRCADIAN RHYTHMS AND LIGHT EXPOSURE. IN PARTICULAR, WHILE NUMEROUS COMMERCIAL WEARABLES EXIST THAT CAN TRACK SLEEP, FEW IF ANY GIVE PERSONALIZED RECOMMENDATIONS FOR HOW LIGHT EXPOSURE AND OTHER BEHAVIORS CAN BE USED TO IMPROVE SLEEP, ESPECIALLY IN POPULATIONS THAT ARE LIKELY TO HAVE HIGHLY DISRUPTED SLEEP. THE PROPOSED PROJECT WILL LEVERAGE CONSUMER WEARABLE TECHNOLOGY TO CONDUCT SLEEP AND CIRCADIAN ANALYSIS FOR CHILDREN WITH ALL FOR THE PURPOSES OF PRESCRIBING LIGHTING AND BEHAVIORAL RECOMMENDATIONS TO HELP IMPROVE SLEEP IN THESE PATIENTS. MOREOVER, WE PROPOSE TO EXTEND THE ANALYSIS AND THE PRESCRIPTIONS BEYOND THE PATIENTS THEMSELVES, TO THEIR CAREGIVERS, IMPROVING OUTCOMES FOR THE ENTIRE FAMILY. SPECIFICALLY, THIS PHASE I STTR PROPOSES TWO AIMS: 1) WE WILL DESIGN A MOBILE APP FOR REDUCING CANCER-RELATED FATIGUE IN PEDIATRIC PATIENTS WITH ALL AND THEIR CAREGIVERS USING A PATIENT-CENTERED APPROACH REFINED WITH FEEDBACK FROM PATIENT-CAREGIVER DYADS, AND 2) WE WILL CONDUCT A USABILITY STUDY IN A POPULATION OF 16 PATIENT-CAREGIVER DYADS TO ASSESS THE FEASIBILITY OF AN APP-DELIVERED LIGHT AND BEHAVIOR-BASED INTERVENTION IN THIS POPULATION. THE RESULTS OF THIS PHASE I APPLICATION WILL PROVIDE THE FOUNDATION NECESSARY TO CONDUCT A PHASE II TRIAL TO ASSESS THE EFFICACY OF THE NEW APP TO REDUCE FATIGUE AND IMPROVE SLEEP QUALITY AND DURATION IN A LARGE POPULATION OF PEDIATRIC ALL PATIENTS AND THEIR CAREGIVERS. ULTIMATELY, WE ANTICIPATE THIS LINE OF RESEARCH WILL LEAD TO THE IDENTIFICATION OF A FEASIBLE, MINIMALLY INVASIVE, EFFECTIVE INTERVENTION TO ADDRESS FATIGUE AND SLEEP ISSUES IN THIS VULNERABLE POPULATION, LEADING TO IMPROVEMENTS IN QUALITY OF LIFE AND OUTCOMES.

AMBIENT LIGHT ACTIVATABLE OPSIN BASED THERAPY FOR AGE-RELATED MACULAR DEGENERATION

IN MISSISSIPPI, EMPOWERING A NEW GENERATION OF AGRICULTURISTS BY ENRICHING THEIR LEARNING EXPERIENCES WITH A MIX OF SCIENTIFIC KNOWLEDGE AND PRACTICAL SKILLS.

ASSESSMENT OF MOBILE APPLICATION-DELIVERED LIGHTING INTERVENTIONS FOR REDUCING CIRCADIAN DISRUPTION IN SHIFT WORKERS - PROJECT SUMMARY SHIFT WORKERS EXPERIENCE PROFOUND CIRCADIAN DISRUPTION, WHICH CAN HAVE DELETERIOUS LONG TERM EFFECTS ON THEIR HEALTH AND QUALITY OF LIFE. MOOD, FATIGUE, AND PERFORMANCE CAN BE IMPROVED IN SHIFT WORKERS BY MOVING THE TIMING OF THEIR PEAK CIRCADIAN DRIVE TO SLEEP OUTSIDE THE HOURS THEY ARE EXPECTED TO WORK. THIS CAN BE ACHIEVED WITH A TARGETED LIGHTING INTERVENTION, AS LIGHT IS THE PRIMARY INPUT TO THE BODY’S CIRCADIAN CLOCK. CRAFTING SUCH AN INTERVENTION FOR AN INDIVIDUAL, HOWEVER, REQUIRES KNOWLEDGE OF THE PERSON’S STARTING CIRCADIAN STATE, WHICH HAS TRADITIONALLY BEEN HARD TO ASSESS IN SHIFT WORKERS. THE GOLD STANDARD MEASURE OF CIRCADIAN TIMING IS DIM LIGHT MELATONIN ONSET, OR DLMO. FOR DAY WORKERS, DLMO MOST COMMONLY OCCURS IN A SIX HOUR WINDOW PRIOR TO HABITUAL BEDTIME. FOR FIXED NIGHT SHIFT WORKERS, HOWEVER, DLMO CAN OCCUR ANYTIME OVER THE 24-HOUR DAY. THIS REQUIRES 24 HOURS OF MELATONIN COLLECTION IN ORDER TO ARRIVE AT A SINGLE INDICATOR OF INTERNAL TIME, WHICH IS OFTEN PROHIBITIVELY TIME CONSUMING AND EXPENSIVE. RECENTLY, WE HAVE DEVELOPED NEW TECHNIQUES FOR NONINVASIVELY PREDICTING CIRCADIAN TIMING THROUGH CONSUMER WEARABLE DEVICES (E.G. APPLE WATCH). THESE TECHNIQUES CAN PREDICT DLMO TIMING TO WITHIN 2 HOURS FOR MORE THAN THREE-QUARTERS OF SHIFT WORKERS WORKING NIGHT SHIFTS. THE PIS OF THIS GRANT HAVE ALSO DEVELOPED MATHEMATICAL TECHNIQUES FOR GENERATING LIGHTING RECOMMENDATIONS BASED ON PREDICTED CIRCADIAN TIMING, AIMED AT SHIFTING THE PEAK CIRCADIAN DRIVE TO SLEEP OUTSIDE THE WINDOW OF WORKING HOURS. IN THIS PHASE I STTR, WE PROPOSE TO DEVELOP AN IOS MOBILE APPLICATION FOR SHIFT WORKERS, TO BOTH TRACK THEIR CIRCADIAN STATE AND TO MAKE RECOMMENDATIONS FOR HOW THEY CAN EXPOSE THEMSELVES TO LIGHT TO FEEL BETTER AND REDUCE THE LONG TERM NEGATIVE HEALTH IMPACTS OF SHIFT WORK. WE WILL DESIGN THE APP BASED ON INTERVIEWS WITH SHIFT WORKERS IN AN ITERATIVE PROCESS. TWENTY-FIVE SHIFT WORKERS WILL BE RECRUITED TO BE IN A USABILITY TRIAL ASSESSING THE APP. WE WILL HAVE THEM WEAR AN APPLE WATCH FOR ONE WEEK PRIOR TO THE START OF THE USABILITY TRIAL TO COLLECT BASELINE DATA, AND WE WILL COLLECT DLMO AT THE CONCLUSION OF THAT WEEK. FOR TWO WEEKS AFTER COLLECTION OF DLMO, WE WILL HAVE THEM INTERACT WITH THE MOBILE APP, INCLUDING FOLLOWING THE RECOMMENDATIONS IT MAKES AND DOCUMENTING THEIR COMPLIANCE WITH THE RECOMMENDATIONS. AT THE CONCLUSION OF THE TRIAL, WE WILL ASK FOR THEIR FEEDBACK ON THE APP IN ORDER TO IMPROVE THE ALGORITHMS AND MAKE UPDATES TO THE DESIGN. ULTIMATELY, AN APP OF THIS KIND COULD INTERFACE WITH HOME AND WORKPLACE SMART LIGHTING SYSTEMS, COULD INFORM EMPLOYER SCHEDULING DECISIONS, AND COULD BE USED TO INCREASE RETENTION IN CRITICAL SHIFT WORK PROFESSIONS WHILE REDUCING THE NEGATIVE HEALTH IMPACTS OF NIGHT SHIFTS ON WORKERS.

SAVI: BUILDING A FRAMEWORK BETWEEN THE EU AND THE USA TO HARMONIZE DATA PRODUCTS RELEVANT TO GLOBAL RESEARCH INFRASTRUCTURES IN THE ENVIRONMENTAL FIE

USA SKY PARTNERS: EXPANDING ACCESS TO AUTHENTIC RESEARCH EXPERIENCES FOR UNDERGRADUATES -THIS AWARD IS FUNDED IN WHOLE UNDER THE AMERICAN RESCUE PLAN ACT OF 2021 (PUBLIC LAW 117-2). AN IMPORTANT MISSION FOR PROFESSIONAL ASTRONOMERS IS TO PROVIDE AN AUTHENTIC ASTRONOMY RESEARCH EXPERIENCE FOR US UNDERGRADUATES, WHERE THEY COMPLETE THE PROGRAM FEELING THAT THE ABILITY TO DO SCIENCE IS PART OF THEIR IDENTITY. TO ACHIEVE THIS, LAS CUMBRES OBSERVATORY (LCO) WILL CREATE A NEW USA SKY PARTNERS PROGRAM WHERE LCO PROVIDES ACCESS TO THEIR GLOBAL ROBOTIC TELESCOPE NETWORK AND PARTNERS WITH US COLLEGES AND UNIVERSITIES THAT REACH STUDENTS FROM GROUPS THAT ARE UNDERREPRESENTED IN ASTRONOMY. THE GOALS OF THIS PILOT PROJECT ARE THREE-FOLD: (1) FULLY DEVELOP PARTNERSHIPS BETWEEN LCO, OCCIDENTAL COLLEGE, AND THE UNIVERSITY OF PUERTO RICO-R?O PIEDRAS THAT PROVIDE REAL ASTRONOMY RESEARCH EXPERIENCES FOR UNDERGRADUATES AT A HISPANIC-SERVING UNIVERSITY AND A SMALL LIBERAL ARTS COLLEGE IN LOS ANGELES WITH A DIVERSE STUDENT POPULATION. (2) DEVELOP THE ONLINE VIDEO AND WRITTEN MATERIALS REQUIRED TO IMPLEMENT THE PILOT STUDENT RESEARCH PROGRAM, IN ENGLISH AND SPANISH, AND RUN THE PROGRAM AT BOTH UNIVERSITY PARTNER INSTITUTIONS. (3) RECRUIT ADDITIONAL INSTITUTIONAL PARTNERS THAT REACH UNDERSERVED COMMUNITIES TO JOIN THE PARTNERSHIP FOR A FUTURE PROPOSAL FOR A LONG-TERM FULL PARTNERSHIP. THE STUDENT RESEARCH PROGRAM IS AN EIGHT-WEEK WORKSHOP THAT CAN BE DONE SEPARATELY OR IN CONJUNCTION WITH AN INTRODUCTORY ASTRONOMY COURSE. THE OBSERVING EXPERIENCE UTILIZES THE TEN 0.4M TELESCOPES IN THE LCO NETWORK. ALL THAT IS REQUIRED TO OBSERVE WITH LCO TELESCOPES IS A COMPUTER WITH ACCESS TO THE INTERNET AND AN ALLOCATION OF TELESCOPE TIME. OBSERVATIONS ARE REQUESTED FROM A WEB BROWSER AND PIPELINE PROCESSED DATA ARE RETURNED VIA THE WEB-BASED ARCHIVE WHEN THE OBSERVATIONS ARE COMPLETE. THE OBSERVATORY SCHEDULING IS AUTOMATED. WITH TEN 0.4M TELESCOPES DEDICATED ALMOST ENTIRELY TO EDUCATION, STUDENTS HAVE A HIGH SUCCESS RATE IN OBTAINING OBSERVATIONS, REGARDLESS OF WHERE THEY ARE PHYSICALLY LOCATED. STUDENTS WILL SELECT TARGETS TO STUDY, LEARN HOW TO USE LCO TELESCOPES, WRITE A BRIEF PROPOSAL FOR THEIR TARGET, MAKE OBSERVATIONS, AND LEARN HOW TO WRITE A PAPER AS PART OF THEIR RESEARCH PROCESS. THIS SEMINAR HAS BEEN DEVELOPED AND SUCCESSFULLY USED IN HIGH SCHOOL ENVIRONMENTS AS PART OF LCO?S GLOBAL SKY PARTNERS PROGRAM. THE SEMINAR ADAPTED FOR UNDERGRADUATES WILL GIVE STUDENTS SUCCESS DOING SCIENCE EVEN IF THEY HAVE NO PREVIOUS EXPERIENCE OR ACCESS TO TELESCOPE FACILITIES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

SBIR PHASE I: IMMERSIVE AUGMENTED REALITY LANDSCAPE VIEWER FOR PUBLIC SPACE DEPLOYMENT

SBIR PHASE I: GRADING 10X FASTER WITH AI ASSISTANCE

TARGETED NANO-ENHANCED OPTICAL DELIVERY OF OPSIN FOR DRY-AMD THERAPY

DEVELOPING A MOBILE APPLICATION FOR CIRCADIAN WELLNESS IN CANCER PATIENTS

INCREASE AJLOUN YOUTH'S ACCESS TO EMPLOYMENT AND SELF-EMPLOYMENT IN IN THE TOURISM AND HOSPITALITY SECTORS

SERVICE BASED INTEGRATION PLATFORM FOR EARTHCUBE (SBIP-E)

AS PART OF THE NATIONAL SCIENCE FOUNDATION EARTHSCOPE PROGRAM, IRIS WILL INSTALL AND MAINTAIN ~260 SEISMIC STATIONS WITH REAL-TIME TELEMETRY IN A GRI

THIS PROJECT AIMS TO IMPROVE THE ECONOMIC PARTICIPATION OF 350 VULNERABLE FEMALE YOUTH IN THREE UNDERSERVED GOVERNORATES IN JORDAN THROUGH STABLE EMPLOYMENT IN THE PRIVATE SECTOR OR THROUGH SELF-EMPLOYMENT.

JOURNEY TO PLANET EARTH: AN ANNUAL REPORT

WE REQUEST SWIFT UV PHOTOMETRY OF 60 SUPERNOVAE (SNE) OVER 2 YEARS TO BE TAKEN IN CONJUNCTION WITH OPTICAL AND IR DATA FROM THE GLOBAL SUPERNOVA PROJECT (GSP).

COLLABORATIVE RESEARCH: COLLECTION OF OPEN DATA FOR BROADBAND SEISMOLOGICAL OBSERVATIONS OF AFTERSHOCKS OF THE FEBRUARY 27 2010 CHILEAN EARTHQUAKE

INVESTIGATING ONGOING EVOLUTION OF THE DIDYMOS SYSTEM FOR THE HERA MISSION FROM GROUND-BASED TELESCOPES

STTR PHASE I: TEST METHODOLOGY FOR MIMO OVER THE AIR TESTING IN A SMALL ANECHOIC CHAMBER

TO SUPPORT LGBTI PACIFIC YOUTH FORUM

US-LATIN AMERICA WORKSHOP: GEOPHYSICAL HAZARDS AND PLATE BOUNDARY PROCESSES; SAN JOSE COSTA RICA OCTOBER 2010

SUBDUCTION ZONE OBSERVATORIES WORKSHOP

SBIR PHASE I: LARGE AREA SCANNING ANGLE-RESOLVED LOW COHERENCE INTERFEROMETRY (A/LCI) FOR ENDOSCOPIC PRECANCER DETECTION

RAPID RESPONSE TOXICOLOGY PREDICTION PLATFORM

COMPUTATIONAL PLATFORM FOR GREEN CHEMISTRY

MARINE SEISMOLOGY SYMPOSIUM 2020

EAGER: COLLABORATIVE RESEARCH: SHALLOW CASED DRILLING CAPABILITIES IN EXTREME ENVIRONMENTS

SBIR PHASE I: INNOVATION FOR AN EASY TO USE CLINICAL A/LCI SYSTEM FOR IN VIVO DETECTION OF PRECANCER

PAN-AMERICAN ADVANCED STUDIES INSTITUTE ON NEW FRONTIERS IN SEISMOLOGICAL RESEARCH: SUSTAINABLE NETWORKS EARTHQUAKE SOURCE PARAMETERS AND EARTH STR

PAN AMERICAN ADVANCED SCIENCES INSTITUTE ON GEOPHYSICAL RESEARCH: NEW TOOLS AND TECHNIQUES FOR EARTHQUAKE HAZARD ANALYSIS & MITIGATION; SANTO DOMINGO

PROJECT TITLE INVESTIGATING ACCESS AND BARRIERS TO USE OF THE SAN DIEGO EMERGENCY APP FOR SHAKEALERT THROUGH A MULTI METHODS APPROACH COLLABORATIVE RESEARCH WITH MIAMI UNIVERSITY AND THE EARTHSCOPE CONSORTIUMPERIOD OF PERFORMANCE 3 15 2023 THROUGH 3 14 2024PLAIN LANGUAGE SUMMARY TO DEVELOP MUTUALLY BENEFICIAL RELATIONSHIPS WITH LIMITED ENGLISH PROFICIENCY (LEP) INDIVIDUALS AND COMMUNITIES AROUND THE SHAKEALERT EARTHQUAKE EARLY WARNING (EEW) SYSTEM. LEP HOUSEHOLDS HAVE NO MEMBER AGED 14 THAT SPEAKS ONLY ENGLISH OR SPEAKS ENGLISH VERY WELL . ACTIVITIES PROJECT ACTIVITIES INCLUDE THE FORMULATION OF FOCUS GROUPS AND SURVEY QUESTIONS IN COLLABORATION WITH THE SDC OES AND THE USGS SHAKEALERT SOCIAL SCIENCE WORKING GROUP. AFTER THE QUESTIONS HAVE BEEN VETTED BY THE WORKING GROUP AND UNDERGONE INSTITUTIONAL REVIEW BOARD APPROVAL AT MIAMI UNIVERSITY, THE PIS WILL CONDUCT SEVERAL FOCUS GROUP MEETINGS IN SAN DIEGO WITH THE PARTNER RELAY COMMUNICATION NETWORK. ONCE DATA COLLECTION IS COMPLETE, WE WILL USE QUALITATIVE CODING TECHNIQUES, SUCH AS CONTENT ANALYSIS, TO ANALYZE THE DATA AND DISSEMINATE OUR RESULTS AT PROFESSIONAL CONFERENCES, COMMUNITY FORUMS, AND IN ACADEMIC PUBLICATIONS.DELIVERABLES AND EXPECTED OUTCOMES TO IDENTIFY AND ADDRESS BARRIERS AND CHALLENGES TO BOTH RECEIPT AND COMPREHENSION OF SHAKEALERT POWERED ALERTS, WITH A FOCUS ON LIMITED ENGLISH PROFICIENCY (LEP) COMMUNITIES IN SAN DIEGO COUNTY. THE GOAL OF THIS WORK IS TO IMPROVE ADOPTION RATES OF THE SD EMERGENCY APP FOR USE AND DISSEMINATION OF SHAKEALERT EEW. IN WORKING WITH PARTNER RELAY, WE WILL DEVELOP AN UNDERSTANDING OF POTENTIAL ACCESS, LANGUAGE, CULTURAL, AND TECHNOLOGICAL BARRIERS TO EEW BROADLY. WE WILL SHARE OUR FINDINGS WITH OTHER SHAKEALERT APP PROVIDERS AND THE USGS JOINT COMMITTEE FOR COMMUNICATION, EDUCATION, OUTREACH AND TECHNICAL ENGAGEMENT TO INFORM FUTURE EFFORTS FOR INCREASING INCLUSIVITY OF EEW.INTENDED BENEFICIARIES SAN DIEGO COUNTY IS HOME TO A DIVERSE POPULATION OF OVER 3.3 MILLION PEOPLE (SERVING 6 OF THE POPULATION COVERED BY SHAKEALERT EEW) THAT IS 34 HISPANIC LATINX AND OVER 12 ASIAN, AND 37 OF THE POPULATION ARE NON ENGLISH SPEAKERS AS A FIRST LANGUAGE (U.S. CENSUS BUREAU, 2021). GIVEN THE DEMOGRAPHICS, SDC PROVIDES AN IDEAL LOCATION IN WHICH TO TEST THE EFFICACY OF SHAKEALERT POWERED ALERTS WITH A DIVERSE GROUP OF PEOPLE. ALERTS PROVIDED THROUGH THE SD EMERGENCY APP ARE CURRENTLY AVAILABLE IN ENGLISH, SPANISH, AMERICAN SIGN LANGUAGE, AND ENGLISH AUDIO TRANSLATIONS. THIS PROJECT INTENDS TO PROVIDE THE USGS WITH KEY INFORMATION ON HOW BEST TO INCREASE THE IMPACT OF SHAKEALERT EEW AND BROADEN THE REACH OF SHAKEALERT WITHIN SAN DIEGO COUNTY AND CALIFORNIA.SUBRECIPIENT ACTIVITIES THE SDC OES IS A SUBRECIPIENT (SUBCONTRACTOR) AND WILL INCORPORATE SILENT ALERT TESTING TO ASSESS ENGAGEMENT AND CONNECTION WITH APP USERS. SILENT ALERT TESTING WILL PING USER PHONES BEHIND THE SCENES TO GATHER INFORMATION ABOUT WHO RECEIVED AN ALERT AND WHERE. SILENT ALERT TESTING WILL ENABLE US TO 1) ASSESS ATTRITION RATES THROUGH APP DOWNLOAD AND DELETION STATISTICS 2) MORE CLEARLY IDENTIFY GEOGRAPHIC GAPS IN ALERTING AND 3) COMPARE THE RESULTS WITH DEMOGRAPHIC INFORMATION TO BETTER UNDERSTAND AND CHARACTERIZE COMMUNITIES WHERE THE APP IS LESS UTILIZED. WE WILL SEEK TO USE SURVEYS AND FOCUS GROUPS IN COMMUNITIES WITH LOW APP UTILIZATION TO BETTER UNDERSTAND USAGE GAPS WITH EEW APPS AND ANY BARRIERS TO APP RETENTION, WHICH WOULD LIMIT THE USEFULNESS OF SHAKEALERT POWERED ALERTS.

SAGAN: SCALABLE ADAPTABLE GRAPH ANALYSIS

THE ROSES FUNDING OPPORTUNITY GOALS ARE: EXECUTE A BALANCED SCIENCE PROGRAM BASED ON DISCIPLINE-SPECIFIC GUIDANCE FROM THE NATIONAL ACADEMIES OF SCIENCES ENGINEERING AND MEDICINE ADMINISTRATION PRIORITIES AND DIRECTION FROM CONGRESS. PARTICIPAT

COLLABORATIVE RESEARCH: CATALYZING EARLY CAREER PARTNERSHIPS TO PROMOTE DISCIPLINE-BASED EDUCATION RESEARCH IN THE GEOSCIENCES

DEVELOPMENT OF ENVIRONMENT-CONTROLLED ENCLOSURES FOR THE NETWORK OF ROBOTIC ECHELLE SPECTROGRAPHS

APPLICATION FOR SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

OUT OF AFRICA: GEOPHYSICAL MONITORING AND CAPACITY BUILDING AROUND THE WORLD, BOSTON MASSACHUSETTS WORKSHOP, FEBRUARY 18-19, 2008

THE PHENOMENON OF MICROLENSING OFFERS US A GLIMPSE OF DARK AND OTHERWISE UNEXPLORED POPULATIONS WITHIN OUR GALAXY. IT IS CAPABLE OF FINDING AND CHARA

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SRSA APPLICATION

COLLABORATIVE RESEARCH: THE EARTH SCIENCE LITERACY INITIATIVE WORKSHOPS

REAP UNDERUTILIZED TECHNOLOGY 24/31

DIRECT COMMUNITY FACILITY LOANS

TO RAISE THE PUBLIC'S AWARENESS OF ARMENIA'S CHALLENGING HUMAN RIGHTS SITUATION AND PROMOTE CITIZEN ADVOCACY TO ADDRESS VIOLATIONS OF HUMAN RIGHTS.

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

KALEIDOSCOPE REAP GRANT AND PROJECT

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

APPLICATION FOR SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

EXPLOSION MECHANISMS AND ENERGY SOURCES POWERING SUPERLUMINOUS SUPERNOVAE

WE PROPOSE TO STUDY A NEW TOOL IN THE QUEST TO UNDERSTAND THE NATURE OF SUPERMASSIVE BLACK HOLES (SMBHS). SMBHS, WITH MASSES ABOVE ONE MILLION TIMES

COLLABORATIVE RESEARCH: USING TUTORIAL-BASED ACTIVE E-LEARNING TO BROADEN PARTICIPATION AND ENHANCE SCIENTIFIC COMPUTING SKILLS IN A SEISMOLOGY CONTEXT

COLLABORATIVE RESEARCH: BRINGING SEISMOLOGY'S GRAND CHALLENGES TO THE UNDERGRADUATE CLASSROOM

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

COLLABORATIVE RESEARCH: COMMUNITY PLANNING FOR SCALABLE CYBERINFRASTRUCTURE TO SUPPORT MULTI-MESSENGER ASTROPHYSICS

TRAVEL PROPOSAL: PROVIDING IRIS UNDERGRADUATE INTERNS WITH A 2018 AGU FALL MEETING EXPERIENCE

PURPOSE: TO SUPPORT TWO BLACK VOICES A COLLABORATIVE PROJECT TO PRESENT TEACH AND STUDY TWO BLACK DANCE VOCABULARIES.

PURPOSE: TO SUPPORT A PERFORMANCE OF NEW AND EXISTING DANCE WORKS.

LPTV - KALEIDOSCOPE FOUNDATION, INC.

EAGER: COLLABORATIVE RESEARCH: SHALLOW CASED DRILLING CAPABILITIES IN EXTREME ENVIRONMENTS

LPTV - KALEIDOSCOPE FOUNDATION, INC.

TO SUPPORT COMMISSIONS OF NEW WORKS FOR CHAMBER ORCHESTRA.

TO SUPPORT A CHOREOGRAPHIC RESIDENCY THAT WILL RESULT IN THE CREATION OF A NEW WORK FOR DANCE KALEIDOSCOPE.

TO SUPPORT THE CREATION AND PRESENTATION OF A NEW WORK, CHOREOGRAPHED BY ARTISTIC DIRECTOR DAVID HOCHOY.

TO SUPPORT THE PRESENTATION OF "REMEMBRANCES," A BALLET IN MEMORY OF VICTIMS OF THE HOLOCAUST.

TO SUPPORT THE "MODERN AMERICAN GRAFFITI" DANCE TOUR IN LOCATIONS IN INDIANA.

UNDERSTANDING THE EFFECTS OF REGIONAL ATTENUATION ON GROUND MOTION MODELS.

THE OCCURRENCE RATE OF PLANETS AS A FUNCTION OF PLANETARY MASS AND ORBITAL PERIOD AND OF STELLAR MASS PROVIDES POWERFUL CONSTRAINTS UPON MODELS OF PLANET FORMATION MIGRATION AND EVOLUTION.

COMMUNITY FACILITY GRANTS

RESEARCH INFRASTRUCTURE: NATIONAL GEOPHYSICAL FACILITY (NGF): ADVANCING EARTH SCIENCE CAPABILITIES THROUGH INNOVATION -- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

ENABLING DISCOVERIES IN MULTISCALE EARTH SYSTEM DYNAMICS: SEISMOLOGICAL FACILITY FOR THE ADVANCEMENT OF GEOSCIENCE (SAGE)

DE-OE0000901 TITLED “AUTOMATED CONFIGURATION ANALYSIS TOOL FOR THE OIL AND NATURAL GAS ENVIRONMENT”

ENABLING DISCOVERIES IN MULTISCALE EARTH SSYSTEM DYNAMICS: GEODETIC FACILITY FOR THE ADVANCEMENT OF GEOSCIENCE (GAGE)

HOME TECHNICAL ASSISTANCE

HOMLES TECH ASST CONT