Anner Incorporated

ALZHEIMER'S PREVENTION INITIATIVE APOE4 TRIAL

ADUCANUMAB ALZHEIMER'S PREVENTION TRIAL

APOE IN THE PREDISPOSITION TO, PROTECTION FROM AND PREVENTION OF ALZHEIMER'S DISEASE

ALZHEIMER'S PREVENTION INITIATIVE ADAD COLOMBIA TRIAL PROGRAM - PROJECT SUMMARY/ABSTRACT WHEN THE API AUTOSOMAL DOMINANT ALZHEIMER'S DISEASE (ADAD) COLOMBIA TRIAL (NCT01998841) WAS ANNOUNCED IN 2012, IT LAUNCHED A NEW ERA IN AD PREVENTION RESEARCH. THE TRIAL LED US TO IDENTIFY ~6,000 PERSONS FROM THE WORLD'S LARGEST ADAD KINDRED, INCLUDING NEARLY 1,200 PRESENILIN 1 (PSEN1) E280A MUTATION CARRIERS, WHO ARE VIRTUALLY CERTAIN TO DEVELOP AD AND BECOME COGNITIVELY IMPAIRED AT 44 (SD ± 5) YEARS OF AGE; ESTABLISH THE CLINICAL TRIALS, INFUSION CAPABILITY, PET, AND MRI INFRASTRUCTURE COLOMBIA NEEDED TO CONDUCT INTERVENTIONAL STUDIES IN THE KINDRED; AND INTRODUCE PRECEDENT SETTING SCIENTIFIC, ETHICAL, SOCIAL SUPPORT, AND LOGISTICAL PARADIGMS AS WELL AS PIONEERING SAMPLE SHARING AGREEMENTS. MOREOVER, IT DEMONSTRATED THE ABILITY TO EVALUATE AN EXPERIMENTAL TREATMENT IN A VULNERABLE POPULATION FROM A DEVELOPING COUNTRY IN WAYS THAT THE PARTICIPANTS VALUED, SUCH THAT 94% OF PARTICIPANTS COMPLETED THE 5-8 YEAR TRIAL. IN RECENT LANDMARK PIVOTAL TRIALS, THE AΒ PLAQUE-CLEARING ANTIBODY (PCA) TREATMENTS LECANEMAB AND DONANEMAB WERE ASSOCIATED WITH A SIGNIFICANT CLINICAL BENEFIT IN MILDLY IMPAIRED LATE-ONSET AD (LOAD) PATIENTS, WITH DRAMATIC AΒ PET AND PLASMA PTAU REDUCTIONS, AND SIGNIFICANT EFFECTS ON OTHER AΒ, TAU, NEURODEGENERATIVE, AND INFLAMMATORY (A/T/N/I) BIOMARKERS. THESE DATA PROVIDED COMPELLING SUPPORT FOR THE ROLE OF AΒ AGGREGATES IN THE DEVELOPMENT, TREATMENT, AND PREVENTION OF AD AND SUPPORT THE USE OF BIOMARKER ENDPOINTS THAT ARE LIKELY TO BE ASSOCIATED WITH A CLINICAL BENEFIT. HERE, WE PROPOSE TO CONDUCT A TWO-PART CLINICAL TRIAL IN 200 COGNITIVELY UNIMPAIRED AND MILDLY IMPAIRED PSEN1 MUTATION CARRIERS AND 40 PLACEBO-TREATED NON-CARRIERS FROM THIS REMARKABLE KINDRED. IN PART 1, CARRIERS WILL RECEIVE UP TO 18 MONTHS OF A PLAQUE-CLEARING ANTIBODY (PCA) TREATMENT (EXEMPLAR: DONANEMAB), PERMITTING US TO COMPARE THE MAGNITUDE OF AΒ PET AND PLASMA PTAU REDUCTIONS IN THIS ADAD KINDRED TO THAT OBSERVED IN TRIALS OF THE SAME DRUG IN AΒ+ MILDLY IMPAIRED LOAD PATIENTS AND COGNITIVELY UNIMPAIRED OLDER ADULTS. IN PART 2, CARRIERS WILL BE RANDOMIZED TO RECEIVE 1) CONTINUED PCA TREATMENT, 2) AN ORAL GAMMA SECRETASE MODULATOR (GSM) TREATMENT (EXEMPLAR: RG6289) WITH THE POTENTIAL TO MINIMIZE THE RE-ACCUMULATION OF AΒ AGGREGATES IN A COMPLEMENTARY, POTENTIALLY LESS EXPENSIVE, AND MORE SCALABLE WAY, 3) COMBINED PCA/GSM TREATMENT, AND 4) PLACEBO TREATMENT FOR 18 MONTHS. THIS SEAMLESS, DOUBLE-BLIND, PLACEBO-CONTROLLED, DOUBLE-DUMMY STUDY OF A PCA AND A GSM IN COGNITIVELY UNIMPAIRED AND MCI/MILD AD PSEN1 E280A MUTATION CARRIERS WILL EFFICIENTLY ADDRESS A NUMBER OF KEY QUESTIONS INCLUDING (1) DETERMINING THE EFFICACY OF A PCA IN REDUCING BRAIN AMYLOID LEVELS IN ADAD; (2) EXAMINING THE RELATIVE EFFICACY OF COMBINATION TREATMENT FOLLOWING PCA TREATMENT VERSUS PCA MONOTHERAPY VERSUS GSM MONOTHERAPY VERSUS PLACEBO TO FURTHER LOWER OR MAINTAIN LOW BRAIN AMYLOID LEVELS AS WELL AS ON DOWNSTREAM BIOMARKERS; (3) ESTIMATING HOW LONG PLACEBO-TREATED MUTATION CARRIERS REMAIN AMYLOID NEGATIVE FOLLOWING PCA- INDUCED AMYLOID CLEARANCE; (4) PROVIDING A FOUNDATION FOR UNDERSTANDING THE LONGER TERM CLINICAL IMPACT OF THE INTERVENTIONS LEVERAGING THE COLOMBIAN API REGISTRY; AND (5) PROVIDING INVALUABLE DATA AND SAMPLES FOR THE FIELD.

PET, APOE & THE PRECLINICAL COURSE OF ALZHEIMER'S DISEASE

ALZHEIMER'S PREVENTION INITIATIVE

ALZHEIMER'S PREVENTION INITIATIVE ADAD COLOMBIA TRIAL

ESTABLISHING THE SCIENCE BEHIND ALZHEIMER'S RECRUITMENT REGISTRIES: OPPORTUNITIES FOR INCREASING DIVERSITY AND ACCELERATING ENROLLMENT INTO TRIALS

NATIONAL BRAIN AND TISSUE RESOURCE FOR PARKINSON'S DISEASE AND RELATED DISORDERS

CYCLOTRON PET AND MRI FACILITY IMPROVEMENT: A SCIENTIFIC RESOURCE FOR ARIZONA

OPTIMIZING RESEARCH INFRASTRUCTURE OF REGISTRIES TO ACCELERATE PARTICIPANT RECRUITMENT INTO ALZHEIMER'S FOCUSED STUDIES - PROJECT SUMMARY/ABSTRACT THE SUFFERING CAUSED BY ALZHEIMER'S DISEASE (AD) IS ONE OF THE GREATEST MEDICAL CHALLENGES OF OUR TIME. WITH A HEIGHTENED SENSE OF URGENCY, NUMEROUS AD PREVENTION TRIALS ARE BEING LAUNCHED, REQUIRING AN UNPRECEDENTED NUMBER OF HEALTHY OLDER ADULTS TO BE SCREENED TO IDENTIFY THE THOUSANDS ELIGIBLE TO PARTICIPATE. AT THE SAME TIME, THE NUMBER OF TRIALS IN AFFECTED INDIVIDUALS AND THEIR CARE PARTNERS CONTINUES TO RISE. IN 2019, THERE WERE 156 TRIALS FOR THE TREATMENT OF AD, AN INCREASE FROM 2018. NOTABLY, THIS NUMBER DOES NOT INCLUDE OBSERVATIONAL STUDIES, WHICH ARE ALSO IMPORTANT TO UNDERSTANDING AD AND DEVELOPING NEW INTERVENTIONS TO TREAT OR PREVENT IT. IMPROVING PARTICIPANT RECRUITMENT METHODS HAS BECOME A CRITICAL PRIORITY FOR THE FIELD. INITIATIVES SUCH AS THE NATIONAL PLAN TO ADDRESS AD CALL FOR GREATER ATTENTION TO INCREASING ENROLLMENT INTO CLINICAL TRIALS AND OTHER CLINICAL RESEARCH. AN OUTGROWTH OF THE NATIONAL PLAN IS THE NATIONAL STRATEGY FOR RECRUITMENT AND PARTICIPATION IN ALZHEIMER'S DISEASE CLINICAL RESEARCH WHICH ENUMERATED FOUR GOALS, ONE OF WHICH IS FOCUSED SPECIFICALLY ON THE NEED TO “BUILD AND IMPROVE RESEARCH INFRASTRUCTURE OF REGISTRIES IN ORDER TO RECRUIT AND RETAIN MORE AND MORE DIVERSE QUALIFIED STUDY PARTICIPANTS.” THE OBJECTIVE OF THIS PROPOSAL IS TO DEVELOP, DEPLOY, OPTIMIZE AND AUTOMATE NEW WEBSITE DESIGN/CONTENT, INFRASTRUCTURE AND FUNCTIONALITY TO SUPPORT AND SUSTAIN ONLINE RECRUITMENT, ENGAGEMENT, AND RETENTION OF ADULTS INTERESTED IN PARTICIPATING IN AD-FOCUSED STUDIES, CREATING A SUSTAINABLE AND ENDURING RESOURCE TO RESEARCHERS. TO ACCOMPLISH THIS, WE WILL BUILD OFF OUR SUCCESSFUL ALZHEIMER'S PREVENTION REGISTRY (APR), AN ONLINE REGISTRY LAUNCHED IN 2012 WITH >350,000 MEMBERS, INCLUDING ~90,000 ENROLLED IN ITS GENEMATCH (GM) PROGRAM LAUNCHED IN 2015 VIA THE FOLLOWING AIMS: 1) DEVELOP, DEPLOY, OPTIMIZE AND AUTOMATE A REFRESHED AND SUSTAINABLE WEBSITE PLATFORM FOR THE RECRUITMENT INTO AND ENGAGEMENT OF MEMBERS IN THE APR AND ITS GM PROGRAM; 2) DEVELOP, DEPLOY, OPTIMIZE AND AUTOMATE A REFRESHED WEBSITE PLATFORM SUPPORTING RESEARCHERS' EFFORTS TO RECRUIT APR AND GM MEMBERS; AND 3) DEVELOP, DEPLOY, OPTIMIZE AND AUTOMATE NEW FUNCTIONALITY AND PROCESSES FOR REFERRING APR AND GM MEMBERS TO AD- FOCUSED STUDIES. WE HYPOTHESIZE THAT THE A) REFRESHED WEBSITE WILL INCREASE ENROLLMENT INTO THE APR AND GM AS WELL AS ENGAGEMENT AND RETENTION OF MEMBERS; B) ENHANCED AD-RESEARCHER EXPERIENCE WILL INCREASE THE NUMBER OF RESEARCHERS / STUDY SPONSORS LEVERAGING THE APR/GM FOR THEIR PARTICIPANT RECRUITMENT NEEDS, ALLOWING THEM TO COMPLETE ENROLLMENT FASTER; AND C) NEW FUNCTIONALITY WILL INCREASE THE PERCENTAGE OF APR AND GM MEMBERS SCREENING FOR AND ENROLLING IN AD-FOCUSED STUDIES.

ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING, AND MISCELLANEOUS GRANTS

THE GE PETTRACE CYCLOTRON: A SCIENTIFIC RESOURCE FOR THE STATE OF ARIZONA

EAST ST. LOUIS HIV/AIDS SUBSTANCE ABUSE TRTMT. PROJECT FOR YOUNG AFRICAN AMERICAN MSM.

FY 2006 BJA SOLICITED AWARDS

BLINDED COMPARISON OF DIFFERENT ALPHA-SYNUCLEIN SEEDING ASSAYS AS CUTANEOUS BIOMARKERS OF LEWY BODY DEMENTIAS - ABSTRACT WITH INCREASING LONGEVITY IN OUR POPULATION, DEMENTIA IS WIDELY RECOGNIZED AS AN IMPENDING PUBLIC HEALTH CRISIS. LEWY BODY DEMENTIA (LBD), ENCOMPASSING DEMENTIA WITH LEWY BODIES (DLB) AND PARKINSON DISEASE DEMENTIA (PDD), IS THE SECOND MOST COMMON CAUSE. LBD IS CHARACTERIZED BY ABNORMAL AGGREGATION AND ACCUMULATION OF A PROTEIN, A-SYNUCLEIN (ASYN). PDD AND DLB ARE CLINICALLY SEPARATED ONLY BY THE RELATIVE TIMING OF THE ONSET OF PARKINSONISM AND DEMENTIA. AT PRESENT, ADVANCES IN THE TREATMENT OF THESE CONDITIONS ARE CRITICALLY HAMPERED BY THE LACK OF NON-INVASIVE, INEXPENSIVE BIOMARKERS THAT CAN PROVIDE ACCURATE DIAGNOSTIC AND PROGNOSTIC INFORMATION. THIS SITUATION MAY SOON BE RESOLVED, AS IN RECENT YEARS IT HAS BECOME APPARENT, THROUGH OUR OWN STUDIES AND THOSE OF OTHERS, THAT BIOPSIES OF PERIPHERAL TISSUE SITES CAN DETECT DIAGNOSTICALLY SIGNIFICANT ASYN. OUR PROJECT WILL ASSESS ASYN IN PUNCH BIOPSIES OF THE SKIN. OUR PRELIMINARY DATA FROM NEW “SEEDING ASSAY” METHODS INCLUDING REAL-TIME QUAKING-INDUCED CONVERSION (RT-QUIC) AND PROTEIN MISFOLDING CYCLIC AMPLIFICATION (PMCA), FROM AUTOPSY-CONFIRMED LBD SUBJECTS, INDICATE HIGH SENSITIVITY AND SPECIFICITY FOR PREDICTING THE PRESENCE OF ASYN IN THE SKIN OF AFFECTED SUBJECTS. FURTHER WORK IS NECESSARY TO CONFIRM THESE RESULTS IN LIVING SUBJECTS WITH THESE CONDITIONS, WHICH IS THE OBJECTIVE OF THIS PROPOSED PROJECT. WE WILL BIOPSY, TWICE DURING A FOUR YEAR PERIOD, 90 SUBJECTS WITH ASYN DISEASE, 30 EACH WITH PD, PDD AND DLB, AS WELL AS 30 NORMAL CONTROL SUBJECTS. TWO INDEPENDENT LABORATORIES WILL BLINDLY PERFORM SEPARATELY-DEVELOPED SEEDING ASSAYS, RIGOROUSLY TESTING THE INTERLABORATORY RELIABILITY AND PROVIDING ESTIMATES OF ASYN DENSITY CHANGE OVER TIME. THE SEEDING ASSAY RESULTS WILL BE COMPARED WITH THOSE OBTAINED BY THE CURRENT GOLD-STANDARD BIOPSY METHOD, IMMUNOHISTOCHEMISTRY (IHC). ALL SUBJECTS WILL RECEIVE COGNITIVE AND MOVEMENT DISORDER ASSESSMENTS AT TWO TIMEPOINTS IN THIS FOUR YEAR PROJECT, ENABLING COMPARISONS OF ASSAY MEASURES WITH COGNITIVE AND MOTOR DECLINE RATES. MANY OF THE SUBJECTS WILL BE ENROLLED IN THE ARIZONA STUDY OF AGING AND NEURODEGENERATIVE DISORDERS (AZSAND), A LONGITUDINAL CLINICOPATHOLOGICAL STUDY WITH AN AUTOPSY RATE EXCEEDING 90%. THIS WILL ALLOW, IN A SUBSTANTIAL SUBSET, EVENTUAL NEUROPATHOLOGICAL CONFIRMATION OF THE MOLECULAR CAUSE OF PARKINSONISM AND DEMENTIA IN EACH SUBJECT.

TRACER HARMONIZATION FOR AMYLOID AND TAU PET IMAGING USING STATISTICAL AND DEEP LEARNING TECHNIQUES - PROJECT SUMMARY/ABSTRACT AMYLOID AND TAU ARE TWO HALLMARK PATHOLOGIES OF ALZHEIMER'S DISEASE (AD), WHICH START TO ACCUMULATE IN THE BRAIN LONG BEFORE CLINICAL SYMPTOM ONSET. WITH THE RECENT DEVELOPMENT OF POSITRON EMISSION TOMOGRAPHY (PET) TRACERS, IN VIVO MEASUREMENTS OF THESE TWO PATHOLOGIES BECAME POSSIBLE AND PLAY IMPORTANT ROLES IN IMPROVING OUR UNDERSTANDING OF AD PATHOGENESIS AND PROGRESSION, AND PROVIDE CRITICAL DIAGNOSTIC AND PROGNOSTIC INFORMATION THAT CAN FACILITATE THE TREATMENT DEVELOPMENT EFFORT NOW AND IMPROVE PATIENT OUTCOME WHEN EFFECTIVE TREATMENTS BECOME AVAILABLE. HOWEVER, MULTIPLE PET TRACERS EXIST FOR BOTH AMYLOID AND TAU IMAGING AND GENERATE IMAGES THAT HAVE DIFFERENT VISUAL APPEARANCES AND QUANTITATIVE CHARACTERISTICS. THESE DIFFERENCES LEAD TO DIFFICULTIES IN COMPARING DIFFERENT STUDIES, LEVERAGING THE LARGE VOLUME OF DATA THAT HAVE BEEN COLLECTED TO DATE, AND DEFINING A COMMON CRITERION FOR POSITIVITY. IN THIS PROJECT, WE WILL FOCUS ON THE DEVELOPMENT OF NOVEL TECHNIQUES THAT CAN HARMONIZE PET IMAGING DATA AND GENERATE HIGHLY COMPATIBLE IMAGING DERIVED MEASUREMENTS. WE ARGUE THAT BY ADOPTING ADVANCED STATISTICAL AND DEEP LEARNING TECHNIQUES AND DEVELOPING NOVEL QUANTIFICATION STRATEGIES THAT TAKE FULL USE OF THE AVAILABLE INFORMATION IN IMAGING DATA, SUCCESSFUL HARMONIZATION CAN BE ACHIEVED VIA GENERALIZABLE APPROACHES. SEVERAL LINES OF RESEARCH SUPPORT THIS ARGUMENT: 1) WE RECENTLY DEMONSTRATED THAT USING PARTIAL VOLUME CORRECTION TECHNIQUE TO REDUCE WHITE MATTER SIGNAL CONTAMINATION, IMPROVED AGREEMENTS IN AMYLOID BURDEN MEASUREMENTS DERIVED FROM PIB AND FLORBETAPIR CAN BE OBTAINED; 2) IN OUR PRELIMINARY ANALYSIS, USING MACHINE LEARNING TECHNIQUE, WE CAN SUBSTANTIALLY IMPROVE BETWEEN-TRACER AGREEMENTS IN GLOBAL AMYLOID BURDEN; 3) RECENT ADVANCEMENT IN DEEP LEARNING RESEARCH DEMONSTRATED THE ABILITY TO “IMPUTE” ONE IMAGING MODALITY FROM ANOTHER BY TAKING ADVANTAGE OF THE INHERENT INFORMATION IN LARGE IMAGING DATASETS, AND OUR PRELIMINARY RESULTS DEMONSTRATED ITS POTENTIAL IN IMAGE HARMONIZATION TASKS. IN THIS PROJECT, WE WILL CONTINUE THIS RESEARCH AND DEVELOP A SET OF TECHNIQUES THAT CAN BE USED TO HARMONIZE AMYLOID IMAGING DATA FROM DIFFERENT TRACERS AND EXTENT THIS APPROACH FOR TAU PET HARMONIZATION. OUR SPECIFIC AIMS ARE 1) TO DEVELOP DEEP LEARNING MODELS THAT CAN GENERATE IMPUTED AMYLOID PET IMAGES FROM ONE TRACER BASED ON THE IMAGES FROM ANOTHER TRACER; 2) TO DEVELOP STATISTICAL LEARNING APPROACHES THAT CAN GENERATE HARMONIZED AMYLOID BURDEN MEASUREMENTS; 3) TO ACQUIRE HEAD-TO-HEAD COMPARISON TAU PET IMAGING DATA AND EXAMINE STATISTICAL AND DEEP LEARNING APPROACHES TO THE HARMONIZATION OF TAU PET IMAGING DATA.

POISON CONTROL STABILIZATION AND ENHANCEMENT PROGRAM

SUPPORT TRAINING ON PREVENTION (STOP)

DNA METHYLATION IN ALZHEIMER?S DISEASE AND NORMALLY AGED BRAIN

POISON CONTROL STABILIZATION AND ENHANCEMENT PROGRAM

SOCIALLY RELEVANT KNOWLEDGE BASED TELEMEDICINE

STUDY ON THALIDOMIDE AS BACE1 INHIBITOR IN ALZHIEMER'S DISEASE

APP/ABETA CHEMISTRY IN TRANSGENIC, FAMILIAL AND SPORADIC AD

GET HEALTHY, LIVE WELL

AGING EFFECTS ON CELLULAR THERAPY FOR HEART FAILURE

QUENCH DETECTION METHOD FOR LARGE SUPERCONDUCTING MAGNETS USING ROBUST MEMS ACOUSTIC SENSOR ARRAYS

GET HEALTHY WEST GEORGIA

SEC. 9007 REAP-RENEW ENERGY SYS GRANTS (MAN)

GET HEALTHY, LIVE WELL

TAS::57 3600::TAS"HIGHER-ORDER MOTION INPUTS FOR VISUAL FIGURE TRACKING: CONTROL ALGORITHMS AND NEURAL CIRCUITS"

HEAAL COALITION DRUG FREE COMMUNITIES PROGRAM

SEE NOTICE OF AWARD, ATTACHMENT 1 - TERMS AND CONDITIONS, ATTACHMENT D, STATEMENT OF WORK, ABSTRACT

HUMAN SPINAL CORD GLIAL CYTOKINES AND CHRONIC PAIN

TRACER HARMONIZATION FOR AMYLOID AND TAU PET IMAGING USING STATISTICAL AND DEEP LEARNING TECHNIQUES - PROJECT SUMMARY/ABSTRACT AMYLOID AND TAU ARE TWO HALLMARK PATHOLOGIES OF ALZHEIMER'S DISEASE (AD), WHICH START TO ACCUMULATE IN THE BRAIN LONG BEFORE CLINICAL SYMPTOM ONSET. WITH THE RECENT DEVELOPMENT OF POSITRON EMISSION TOMOGRAPHY (PET) TRACERS, IN VIVO MEASUREMENTS OF THESE TWO PATHOLOGIES BECAME POSSIBLE AND PLAY IMPORTANT ROLES IN IMPROVING OUR UNDERSTANDING OF AD PATHOGENESIS AND PROGRESSION, AND PROVIDE CRITICAL DIAGNOSTIC AND PROGNOSTIC INFORMATION THAT CAN FACILITATE THE TREATMENT DEVELOPMENT EFFORT NOW AND IMPROVE PATIENT OUTCOME WHEN EFFECTIVE TREATMENTS BECOME AVAILABLE. HOWEVER, MULTIPLE PET TRACERS EXIST FOR BOTH AMYLOID AND TAU IMAGING AND GENERATE IMAGES THAT HAVE DIFFERENT VISUAL APPEARANCES AND QUANTITATIVE CHARACTERISTICS. THESE DIFFERENCES LEAD TO DIFFICULTIES IN COMPARING DIFFERENT STUDIES, LEVERAGING THE LARGE VOLUME OF DATA THAT HAVE BEEN COLLECTED TO DATE, AND DEFINING A COMMON CRITERION FOR POSITIVITY. IN THIS PROJECT, WE WILL FOCUS ON THE DEVELOPMENT OF NOVEL TECHNIQUES THAT CAN HARMONIZE PET IMAGING DATA AND GENERATE HIGHLY COMPATIBLE IMAGING DERIVED MEASUREMENTS. WE ARGUE THAT BY ADOPTING ADVANCED STATISTICAL AND DEEP LEARNING TECHNIQUES AND DEVELOPING NOVEL QUANTIFICATION STRATEGIES THAT TAKE FULL USE OF THE AVAILABLE INFORMATION IN IMAGING DATA, SUCCESSFUL HARMONIZATION CAN BE ACHIEVED VIA GENERALIZABLE APPROACHES. SEVERAL LINES OF RESEARCH SUPPORT THIS ARGUMENT: 1) WE RECENTLY DEMONSTRATED THAT USING PARTIAL VOLUME CORRECTION TECHNIQUE TO REDUCE WHITE MATTER SIGNAL CONTAMINATION, IMPROVED AGREEMENTS IN AMYLOID BURDEN MEASUREMENTS DERIVED FROM PIB AND FLORBETAPIR CAN BE OBTAINED; 2) IN OUR PRELIMINARY ANALYSIS, USING MACHINE LEARNING TECHNIQUE, WE CAN SUBSTANTIALLY IMPROVE BETWEEN-TRACER AGREEMENTS IN GLOBAL AMYLOID BURDEN; 3) RECENT ADVANCEMENT IN DEEP LEARNING RESEARCH DEMONSTRATED THE ABILITY TO “IMPUTE” ONE IMAGING MODALITY FROM ANOTHER BY TAKING ADVANTAGE OF THE INHERENT INFORMATION IN LARGE IMAGING DATASETS, AND OUR PRELIMINARY RESULTS DEMONSTRATED ITS POTENTIAL IN IMAGE HARMONIZATION TASKS. IN THIS PROJECT, WE WILL CONTINUE THIS RESEARCH AND DEVELOP A SET OF TECHNIQUES THAT CAN BE USED TO HARMONIZE AMYLOID IMAGING DATA FROM DIFFERENT TRACERS AND EXTENT THIS APPROACH FOR TAU PET HARMONIZATION. OUR SPECIFIC AIMS ARE 1) TO DEVELOP DEEP LEARNING MODELS THAT CAN GENERATE IMPUTED AMYLOID PET IMAGES FROM ONE TRACER BASED ON THE IMAGES FROM ANOTHER TRACER; 2) TO DEVELOP STATISTICAL LEARNING APPROACHES THAT CAN GENERATE HARMONIZED AMYLOID BURDEN MEASUREMENTS; 3) TO ACQUIRE HEAD-TO-HEAD COMPARISON TAU PET IMAGING DATA AND EXAMINE STATISTICAL AND DEEP LEARNING APPROACHES TO THE HARMONIZATION OF TAU PET IMAGING DATA.

THE PROJECT WILL ADDRESS IMPROVING THE INDOOR AIR QUALITY IN SCHOOL FACILITIES THROUGH INFORMATION DISSEMINATION, TRAINING SESSIONS, AND EDUCATIONAL

AN AUTONOMOUS ROBOT FOR FIELD TRANSPORT OF STRAWBERRIES

ALZHEIMER'S DISEASE: A BLOOD DIAGNOSTIC AND BIOMARKER OF DISEASE PROGRESSION

RURAL HEALTH CARE SERVICES OUTREACH GRANT PROGRAM

SUPPORT TRAINING ON PREVENTION (STOP)

THE PURPOSE OF THE COPS OFFICE SCHOOL VIOLENCE PREVENTION PROGRAM (SVPP) IS TO IMPROVE SECURITY AT SCHOOLS AND ON SCHOOL GROUNDS THROUGH SCHOOL SAFETY PROGRAMS AND TECHNOLOGY. FUNDING UNDER THIS AWARD PROGRAM WILL BE USED BY THE SCHOOL JURISDICTION TO IMPLEMENT EVIDENCE-BASED PROGRAMS TO IMPROVE SCHOOL SECURITY AND PROMOTE A POSITIVE LEARNING ENVIRONMENT FOR ALL STUDENTS.

REAP RENEWABLE ENERGY SYSTEM (RES) GRANT UNRESTRICTED AMOUNT

PERIPHERAL BIOMARKERS IN FAMILIAL ALZHEIMER'S DISEASE

HEALTH CARE AND OTHER FACILITIES

RESIDENTS IN WEST GEORGIA CONTINUE TO SUFFER DISPROPORTION BURDENS OF POVERTY, FOOD INSECURITY AND CHRONIC DISEASE THAN OTHER PARTS OF THE STATE AND COUNTRY, AND MANY LOW-INCOME CONSUMERS LACK KNOWLEDGE OF WHERE TO ACCESS HEALTHY, AFFORDABLE FOODS AND HOW TO USE THEM NUTRITIOUSLY. SEEKING TO ADVANCE REGIONAL FOOD SECURITY AND COMMUNITY HEALTH IN CARROLL, HARALSON AND HEARD COUNTIES AND FURTHER ADDRESS IDENTIFIED COMMUNITY GAPS AND NEEDS, TANNER MEDICAL CENTER, INC. AND THE WEST GEORGIA REGIONAL FOOD SYSTEM COLLABORATIVE (WITH MORE THAN 30 REPRESENTATIVES FROM THE LOCAL FOOD INDUSTRY, AGRICULTURAL SECTOR, SCHOOLS AND SOCIAL AGENCIES) MOBILIZED MEMBERS TO CREATE SOLUTIONS TO ADDRESS THE CHALLENGES REGARDING LOCAL FOOD ACCESS, FARM AND NUTRITION ISSUES. THE ENSUING FOUR-YEAR CFPCGP PROJECT WORK PLAN WAS DESIGNED TO BUILD UPON THE STRENGTHS OF THE WEST GEORGIA REGIONAL FOOD SYSTEM COLLABORATIVE, LOCAL NETWORKS AND COMMUNITY ORGANIZATIONS IN ORDER TO: INCREASE ACCESS TO LOCAL HEALTHY FOODS, PARTICULARLY FOR VULNERABLE POPULATIONS; INCREASE AWARENESS ABOUT FOOD SECURITY AND INCREASE FOOD KNOWLEDGE AND SKILLS; AND INCREASE KNOWLEDGE AND RESOURCES FOR LOCAL FARMERS TO DEVELOP AND SUSTAIN SUCCESSFUL AGRICULTURAL ENTERPRISES. PROJECT ACTIVITIES INCLUDE: THE DEVELOPMENT OF A NEW FARMERS' MARKET PAVILION, CENTRALLY LOCATED AT THE INTERSECTION OF FIVE FOOD DESERT CENSUS TRACTS IN CARROLL COUNTY; WORKING WITH AREA FOOD PANTRIES TO IMPROVE THE QUALITY OF FOOD PROVIDED; IMPLEMENTING COMMUNITY-WIDE NUTRITION EDUCATION PROGRAMMING, TARGETING LOW-INCOME INDIVIDUALS; AND PROVIDING COMPREHENSIVE TRAINING PROGRAMS TO HELP LOCAL FARMERS STRENGTHEN THEIR BUSINESS SKILLS AND MANAGERIAL CAPACITY TO ESTABLISH, IMPROVE AND SUSTAIN THEIR OPERATIONS.

BETA-AMYLOID PEPTIDES IN THE OLDEST-OLD: A BIOCHEMICAL PROFILE OF SUCCESSFUL AGIN

ARE THE SUPPRESSORS OF CYTOKINE SIGNALING INVOLVED IN ALZHEIMER'S DISEASE?

THE COUNCIL OF EDUCATIONAL FACILITY PLANNERS (CEFPI) REPRESENTS SCHOOL DISTRICT FACILITY MANAGERS PLANNERS AND STATE SCHOOL FACILITY DIRECTORS -- TH

AFFORDABLE CARE ACT (ACA) GRANTS FOR SCHOOL-BASED HEALTH CENTERS CAPITAL PROGRAM

TANNER MEDICAL CENTER, INC. "NOW IS THE TIME" PROJECT AWARE-COMMUNITY

BLACK FARMERS UNITE TO ELIMINATE URBAN FOOD DESERT

POISON CONTROL AND STABILIZATION AND ENHANCEMENT PROGRAM

SUPPORT YSEALI URBAN PLANNING AND SMART GROWTH WORKSHOP

TANNER COMMUNITY DEVELOPMENT CORPORATION (TCDC)HELP ENRICH AFRICAN AMERICAN LIVES (HEAAL) COALITION DRUG FREE COMMUNITIES PROGRAM

COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - CONSTRUCTION - FLANNER HOUSE SERVES A HISTORICALLY DISADVANTAGED REGION OF INDIANAPOLIS WITH THE AREA POPULATION FACING SIGNIFICANT BARRIERS SUCH AS LACK OF CHILDCARE, COMPUTER ACCESS AND EXPERTISE, TRANSPORTATION, INADEQUATE HOUSING, FOOD, AND SOFT SKILLS AS WELL AS MENTAL HEALTH ISSUES, SUBSTANCE ABUSE PROBLEMS, CRIMINAL HISTORY, LANGUAGE BARRIERS, AND POOR SELF-IMAGE. 75% OF OUR ADULT CLIENTS ARE SINGLE FEMALE HEAD OF HOUSEHOLD WITH CHILDREN AT 200% OR LESS OF POVERTY. 92% OF THE TOTAL POPULATION ARE UNEMPLOYED OR UNDEREMPLOYED. MOST OF THESE FAMILIES HAVE A NEGATIVE NET WORTH. OVER HALF ARE TECHNICALLY HOMELESS. ONLY ONE-THIRD HAVE A GED EQUIVALENT OR HS DIPLOMA. RESEARCH SHOWS THAT EXPOSURE TO VIOLENCE, INCARCERATION, AND INVOLVEMENT IN THE FOSTER CARE SYSTEM CAN INCREASE THE CHANCES OF DEVELOPING A MENTAL ILLNESS. CONSEQUENTLY, THE BLACK COMMUNITY, IN PARTICULAR, IS AT SIGNIFICANTLY INCREASED RISK OF DEVELOPING A MENTAL HEALTH ISSUE DUE TO THESE BARRIERS AND HISTORICAL, ECONOMIC, SOCIAL, POLITICAL INFLUENCES THAT SYSTEMICALLY EXPOSE THE BLACK COMMUNITY TO PSYCHOLOGICALLY AND PHYSICALLY DAMAGING FACTORS. FURTHERMORE, ENVIRONMENTAL CONDITIONS DO LITTLE TO HELP, AS STIGMA AND JUDGMENT OFTEN STOP BLACK/AFRICAN-AMERICANS FROM SEEKING TREATMENT FOR THEIR MENTAL ILLNESSES. MANY BELIEVE THAT DISCUSSIONS ABOUT MENTAL ILLNESS WOULD NOT BE APPROPRIATE EVEN AMONG FAMILY AND THAT EXPRESSION OF MENTAL DISTRESSES WOULD MAKE THEM BE CONSIDERED “CRAZY” IN THEIR SOCIAL CIRCLES. WITH THE LACK OF QUALITY OF MENTAL HEALTHCARE IN COMMUNITIES OF COLOR HAVING BEEN A LONG-UNRESOLVED ISSUE, WE BELIEVE THAT CULTURALLY-RESPONSIVE MENTAL HEALTH TREATMENT IS ONE WAY OF ADDRESSING THE DISPARITIES IN PSYCHOLOGICAL WELLBEING IN THE BLACK COMMUNITY. FLANNER HOUSE, WORKING WITH URBAN MINISTRIES, HAS GAINED APPROVAL TO BILL MEDICAID FOR AFFORDABLE AND FREE COUNSELING SERVICES TO OUR CLIENTS. OUR GOAL TO IS PROVIDE AN ESTABLISHED SITE WITH ON-SITE LICENSED COUNSELORS AND THERAPY SO THAT I NDIVIDUALS AND FAMILIES ARE COMFORTABLE IN A SETTING THAT IS FAMILIAR TO THEM AND COUNSELORS AND THERAPY THAT CAN BRING RELATABLE EXPERIENCES AND STEPS IN THE CONTEXT IN WHICH THEY LIVE. FURTHER DEVELOPMENT WILL PROCEED IN TWO PHASES: - IN PHASE ONE, FLANNER HOUSE WILL OFFER THE FOLLOWING SERVICES NECESSARY FOR THE EXPANSION OF THE COMMUNITY MENTAL HEALTH AND WELLNESS CENTER. THIS INCLUDES OUTREACH ACTIVITIES TO RECRUIT AND ENGAGE PARTICIPANTS, PROPER CASE COORDINATION AND SERVICE DELIVERY, DATA TRACKING AND POST-PROGRAM FOLLOW-UP. PHASE TWO INCLUDES OUR TEAM IMPLEMENTING A SYSTEM FOR MONITORING, AND THE EVALUATION AND PILOTING OF PROMISING PRACTICES WITH BOTH QUANTITATIVE AND QUALITATIVE OUTCOMES. THIS PHASE WILL INVOLVE OUR MORNINGSTAR TEAM EVALUATING DOCUMENTED BEST PRACTICES FOR TREATING BLACK PATIENTS. BASED ON CURRENT DEMAND, WE ANTICIPATE OFFERING 5 COUNSELING SESSIONS PER HOUR FOR 5 DAYS PER WEEK OR 125 HOURS PER WEEK WHEN THE CENTER IS FULLY STAFFED. THE SERVICES PROVIDED WILL BE ONE-ON-ONE SESSIONS IN A COMFORTABLE AND CONFIDENTIAL SETTING. GROUP THERAPY OPTIONS WILL ENGAGE THE FAMILY AS A WHOLE, OR PEERS. STAFF WILL ALSO DEVELOP PLANS FOR HOME-BASED INTERVENTIONS. THIS INVESTMENT IS ALIGNED WITH OUR QUALITY OF LIFE PLAN FOR KING COMMONS AS IT SUPPORTS THE WELL-BEING OF INDIVIDUALS IN THE COMMUNITY AND CREATES SERVICES THAT ARE PLACE BASED AND CULTURALLY CONTEXTUALIZED. WE WILL SUPPORT THE CREATION OF NEW JOBS, INCLUDING MORNINGSTAR COMMUNITY MENTAL HEALTH CENTER (CMHC) PROGRAM MANAGER AND CMHC FACILITY MANAGER.

ASSISTANCE TO FIREFIGHTERS GRANT

ASSISTANCE TO FIREFIGHTERS GRANT

SBIR PHASE I: INTEREST-ALIGNED COLLEGE DEGREE PLANNING WITHIN AN OPTIMIZED MULTIPLAN FRAMEWORK

ASSISTANCE TO FIREFIGHTERS GRANT

DISPOSABLE MEMS-BASED RAMAN MICRO-SPECTROMETER FOR IMPROVED CHARACTERIZATION OF WASTE IN TANKS AND ANCILLARY PIPING

ASSISTANCE TO FIREFIGHTERS GRANTS

"MECHANISMS FOR VISUAL DETECTION OF SMALL TARGETS IN INSECTS"

CARDIOVASCULAR GENOTYPE AND APOE ?4 CARRIER STATUS INTERACTION EFFECTS ON AMYLOID LOAD IN PRE-CLINICAL ALZHEIMER'S DISEASE - PROJECT SUMMARY RESEARCH AND TREATMENT APPROACHES IN PRE-CLINICAL ALZHEIMER'S DISEASE (AD) HAVE FOCUSED PRIMARILY ON THE DEPOSITION AND CLEARANCE OF BETA-AMYLOID WHICH LEADS TO THE FORMATION OF CORTICAL PLAQUES AND NEUROFIBRILLARY TANGLES, A HALLMARK OF AD PATHOLOGY. HOWEVER, THE ROLE THAT VASCULAR FACTORS MAY HAVE IN THE DEVELOPMENT OF THESE PATHOLOGIES IS NOT CLEAR. EPIDEMIOLOGICAL STUDIES HAVE SUGGESTED THAT RISK FACTORS SUCH AS HIGH CHOLESTEROL, HYPERTENSION, TYPE 2 DIABETES, AND INFLAMMATION ARE ASSOCIATED WITH AN INCREASED RISK OF DEVELOPING AD. SEVERAL STUDIES HAVE DEMONSTRATED THAT CERTAIN CARDIOVASCULAR GENETIC MARKERS ARE ASSOCIATED WITH CLINICAL AD AND ITS PATHOLOGICAL HALLMARKS. SPECIFIC POLYMORPHISMS OF THE CRP GENE (RS3091244, AND RS3093075) ARE ASSOCIATED WITH GREATER PLAQUE LOAD WHILE THE RS1205 AND RS2794521 POLYMORPHISMS APPEARS TO PROTECT AGAINST AMYLOID DEPOSITION. THE METHYLENETETRAHYDROFOLATE REDUCTASE (MTHFR) GENE HAS BEEN IMPLICATED AS A SUSCEPTIBILITY MARKER FOR AD AND IS ALSO RECOGNIZED AS AN IMPORTANT FACTOR IN CARDIOVASCULAR DISEASE DUE TO ITS ROLE IN REGULATING HOMOCYSTEINE. THE MTHFR C677T (RS1801133) POLYMORPHISM IS A MARKER OF INTEREST IN BOTH THE AD AND CARDIOVASCULAR CONTEXTS AND IT IS NOTED THAT THIS POLYMORPHISM INTERACTS WITH APOE CARRIER STATUS ON CARDIOVASCULAR OUTCOMES. THERE IS ALSO EVIDENCE THAT THE RS1801131 POLYMORPHISM INFLUENCES THE RISK OF AD AND HAS SHOWN TO MODERATE THE EFFECT OF APOE ON AD RISK. VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) HAS ALSO BEEN IMPLICATED IN AD AS THE C2578A ALLELE (RS699947) HAS BEEN ASSOCIATED WITH AN INCREASED RISK FOR AD IN WHICH A SIGNIFICANT VEGF BY APOE INTERACTION MAY PLAY A ROLE. THE G1154A (RS1570360) POLYMORPHISM OF VEGF HAS SHOWN TO HAVE A PROTECTIVE EFFECT FOR AD. THE KINESIN FAMILY MEMBER 6 (KIF6) GENE'S 719ARG POLYMORPHISM (RS20455) HAS BEEN STRONGLY IMPLICATED IN THE RISK FOR CARDIOVASCULAR EVENTS, BUT ITS POSSIBLE ROLE IN AD HAS NOT BEEN FULLY INVESTIGATED. THE RS3025039 POLYMORPHISM HAS ALSO SHOWN CONSISTENT ASSOCIATIONS WITH CARDIOVASCULAR DISEASE HOWEVER ITS LINK WITH AD RISK OR PATHOLOGY IS UNKNOWN. THE AIM OF THIS STUDY WILL BE TO EXAMINE THE EFFECTS OF THESE CARDIOVASCULAR GENE MARKERS ON IMAGING-BASED MEASURES OF AMYLOID IN COGNITIVELY UNIMPAIRED OLDER ADULTS. THIS STUDY WILL ALSO EXPLORE WHETHER THE INTERACTIONS BETWEEN APOE E4 CARRIER STATUS AND THESE ALLELES ARE ASSOCIATED WITH IN VIVO PLAQUE AND TANGLE LOAD.

BOLD AND PERFUSION FMRI OF ALZHEIMER'S DISEASE RISK

STAFFING FOR ADEQUATE FIRE AND EMERGENCY RESPONSE (SAFER)

ASSISTANCE TO FIREFIGHTERS GRANT

HEAAL COALITION DRUG FREE COMMUNITIES PROGRAM

RURAL HEALTH NETWORK DEVELOPMENT PLANNING GRANT PROGRAM

AN AUTONOMOUS PALLET-STACKING ROBOT FOR FIELD USE

AN AUTONOMOUS ROBOT FOR FIELD TRANSPORT OF STRAWBERRIES

RURAL HEALTH NETWORK DEVELOPMENT PLANNING GRANT PROGRAM

REAP ENERGY EFFICIENCY IMPROVEMENT (EEI) GRANT UNRESTRICTED AMOUNT

PURPOSE: TO SUPPORT THE CREATION OF TEMPORARY PUBLIC ART AND RELATED COMMUNITY ENGAGEMENT PROGRAMMING IN NEIGHBORHOODS ACROSS INDIANAPOLIS, INDIANA.

PARKLINE LOFTS AND YARD

CARES FUNDING FOR POISON CENTERS

SRSA APPLICATION

TO PROVIDE SUPPORT COSTS TO INSTITUTE OF TOWN PLANNERS SRI LANKA TO CARRY OUT A PROJECT SUPPORTED BY THE U.S. AMBASSADORS FUND FOR CULTURAL PRESERVAT

SEC. 9007 REAP-RENEW ENERGY SYS GRANTS (MAN)

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SEC. 9007 REAP-RENEW ENERGY SYS GUAR. LOAN & GRANT COMBO (MAN)

SEC. 9007 REAP-ENERGY EFFICIENCY IMPROVEMENTS GRANTS (MAN)

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SEC. 9007 REAP-ENERGY EFFICIENCY IMPROVEMENTS GRANTS (MAN)

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

COMMUNITY FACILITY GRANTS

SEARCH GRANTS - WATER ONLY

APPLICATION FOR SMALL RURAL SCHOOL ACHIEVEMENT PROGRAM

SEC. 9007 REAP-RENEW ENERGY SYS GRANTS (MAN)

SRSA APPLICANT

THE STAR-SPANGLED BANNER FLAG HOUSE WILL CRAFT A NEW INTERPRETIVE PLAN USING RESEARCH AND VISITOR EXPERIENCE DATA TO INCLUDE MORE EQUITABLE, DIVERSE, AND INCLUSIVE STORIES IN THE BROADER NARRATIVE OF INTERPRETATION SURROUNDING THE CREATION OF THE STAR-SPANGLED BANNER FLAG AND BALTIMORE, MARYLAND, HISTORY. THE FLAG HOUSE WILL GATHER STORIES OF FEMALE APPRENTICES, FREE AND ENSLAVED AFRICAN AMERICAN WOMEN AND CHILDREN, AND EASTERN EUROPEAN AND ITALIAN IMMIGRANTS WHO LIVED AND WORKED IN THE HISTORIC FLAG HOUSE FROM 1807 UNTIL 1927. THE VISITOR EXPERIENCE WILL CONNECT AUDIENCES WITH MORE DIVERSE STORIES AND THEMES THAT PROMOTE CRITICAL THINKING.

APPLICATION FOR SMALL RURAL SCHOOL ACHIEVEMENT PROGRAM

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

MARYLAND'S AMERICA: 250 YEARS OF AMERICAN HISTORY THROUGH MARYLANDER EYES [THE FLAG HOUSE IS CREATING A NEW, TWO-YEAR EXHIBIT WHICH WILL ENGAGE COMMUNITY ARTISTS FROM ACROSS THE STATE AS THEY CREATE A UNIQUE PIECE OF WORK HIGHLIGHTING MARYLANDER CONTRIBUTIONS TO AMERICAN HISTORY. THE ARTISTS SELECTED WILL REPRESENT THE MULTICULTURAL AND DEMOGRAPHICALLY BLENDED COMMUNITIES FROM ACROSS THE STATE AND HAVE A CHANCE TO CREATE A NEW PIECE OF WORK TO ENGAGE IN CHALLENGING HISTORICAL CONVERSATIONS. PARTNERING WITH THE PRIDE OF BALTIMORE II AND FORT MCHENRY, THE ARTISTS SELECTED WILL HAVE THE OPPORTUNITY TO RECREATE FRANCIS SCOTT KEY?S INSPIRATION AS THEY SAIL OUT TO THE SAME LOCATION AND WITNESS THE STAR-SPANGLED BANNER FLAG HOISTED OVER FORT MCHENRY. THEN, WITH THIS SHARED EXPERIENCE, THEY WILL BE ASKED TO INDIVIDUALLY CREATE A UNIQUE PIECE OF WORK THAT REFLECTS THE EMOTIONS EVOKED WHILE WITNESSING THE FLAG AND SIMULTANEOUSLY HIGHLIGHTING 250 YEARS OF MARYLAND-AMERICAN EXPERIENCES WHICH WILL BE DISPLAYED IN A NEW FLAG HOUSE EXHIBIT.]

BRUSH MANAGEMENT ON 158 ACRES OF UPLAND HABITAT TO THIN ASHE JUNIPER AND OTHER WOODY PLANTS INVADING GRASSLAND AND WOODLAND HABITATS AT UNDESIRABLE DENSITIES BRUSH MANAGEMENT WILL INVOLVE CUTTING TREES WITH A SKID STEER LOADED EQUIPPED WITH A HYDRAULIC SHEARING DEVICE, BY MULCHING WITH A FORESTRY MULCHER, BY USE OF AN EXCAVATOR AND INDIVIDUAL PLANT TREATMENT, OR BY HAND WITH POWER SAWS, BUT NOT BY PUSHING WITH A BULLDOZER TO AVOID ADVERSELY AFFECTING NESTING ACTIVITIES OF THE ENDANGERED GOLDEN CHEEKED WARBLER, MECHANICAL TREATMENTS SHOULD BE IMPLEMENTED ONLY DURING THE NON BREEDING SEASON SEPTEMBER THROUGH FEBRUARY ONLY SINGLE STEM TRUNK TREES THAT ARE 5 INCH DBH OR THAT ARE MULTI SPROUTING FROM THE BASE CAN BE REMOVED THE END GOAL OF THIS PROJECT IS TO REMOVE UP TO 75 OF JUNIPER IN THE PROJECT SITE WHILE NOT ENTERING DRAINAGE AREAS OR STEEP SLOPES TO MAINTAIN HABITAT DIVERSITY, SELECTED JUNIPER MOTTS THROUGHOUT THE SITE WILL NOT BE REMOVED

TO ENHANCE 186 ACRES OF ASHE JUNIPER ENCROACHED WOODLAND IN EDWARDS COUNTY.

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

APPLICATION FOR SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

REAP RENEWABLE ENERGY SYSTEM (RES) GRANT UNRESTRICTED AMOUNT

APPLICATION FOR SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

REAP RENEWABLE ENERGY SYSTEM (RES) GRANT UNRESTRICTED AMOUNT

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

APPLICATION FOR SMALL RURAL SCHOOL ACHIEVEMENT PROGRAM

THIS PROJECT WILL PROVIDE TRUST RESOURCE PUBLIC BENEFITS THROUGH IMPROVING UPLAND WOODLAND HABITAT FOR THE BENEFIT OF MULTIPLE FEDERAL TRUST SPECIES, INCLUDING THE ENDANGERED GOLDEN-CHEEKED WARBLER, MIGRATORY BIRDS, MONTEZUMA QUAIL, AND POLLINATORS, INCLUDING THE MONARCH BUTTERFLY.BRUSH MANAGEMENT ON 140 ACRES (REFERENCE MAP ATTACHED) OF UPLAND HABITAT TO THIN ASHE JUNIPER AND OTHER WOODY PLANTS INVADING GRASSLAND AND WOODLAND HABITATS AT UNDESIRABLE DENSITIES. BRUSH MANAGEMENT WILL INVOLVE CUTTING TREES WITH A SKID-STEER LOADED EQUIPPED WITH A HYDRAULIC SHEARING DEVICE, BY MULCHING WITH A FORESTRY MULCHER, OR BY HAND WITH POWER SAWS, BUT NOT BY PUSHING WITH A BULLDOZER. TARGETED JUNIPER DENSITY AFTER TREATMENT IS 50 PERCENT IN A MOSAIC PATTERN. MECHANICAL TREATMENT MAY BE MODIFIED WITH USFWS PROJECT OFFICER APPROVAL. ASHE JUNIPER (CEDAR) CAN SIMPLY BE CUT AND ALLOWED TO LAY IN PLACE. MESQUITE AND RED-BERRY JUNIPER AND OTHER BRUSH (SPROUTING SPECIES) WILL NEED TO BE CUT AND IMMEDIATELY TREATED WITH AN APPROPRIATE HERBICIDE (BASAL-BARK CUT-STUMP TREATMENT IS RECOMMENDED).

THIS PROJECT WILL PROVIDE TRUST RESOURCE PUBLIC BENEFITS THROUGH IMPROVING UPLAND WOODLAND HABITAT FOR THE BENEFIT OF MULTIPLE FEDERAL TRUST SPECIES, INCLUDING THE FEDERALLY PROPOSED MONARCH BUTTERFLY, MIGRATORY BIRDS, AND OTHER POLLINATORS.THE OBJECTIVE OF THIS PROJECT IS TO RESTORE AND ENHANCE SOME OF THE HISTORIC SAVANNA GRASSLAND COMMUNITIES THAT CURRENTLY EXIST AS JUNIPER SCRUBLAND BY MECHANICALLY TREATING INVADING JUNIPER AND OTHER WOODY SPECIES, CONCOMITANTLY STIMULATING HERBACEOUS GRASSES, FORBS, AND SHRUBS. UPLAND HABITAT ENHANCEMENT HAS BEEN DESIGNED TO IMPROVE COVER OF DESIRABLE HERBACEOUS SPECIES INCLUDING WARM-SEASON PERENNIAL GRASSES THAT SHOULD IMPROVE RAINWATER RETENTION, PROMOTE SOIL CONSERVATION, AND OTHERWISE PROVIDE FOR IMPROVED WATERSHED HEALTH, ALL OF WHICH ARE SHOWING BENEFITS FROM PAST HABITAT WORK.ADDITIONALLY, IMPROVED GRASSLAND HEALTH AND CONCOMITANT WATERSHED ENHANCEMENT COULD ULTIMATELY BENEFIT WATER QUALITY AND QUANTITY FOR THE BENEFIT OF NUMEROUS FISH AND WILDLIFE SPECIES.

SRSA APPLICATION

APPLICATION FOR SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

APPLICATION FOR SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

APPLICATION FOR SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

APPLICATION FOR SMALL RURAL SCHOOL ACHIEVEMENT PROGRAM

APPLICATION FOR SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SRSA APPLICATION

APPLICATION FOR SMALL RURAL SCHOOL ACHIEVEMENT PROGRAM

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SRSA APPLICATION

APPLICATION FOR SMALL RURAL SCHOOL ACHIEVEMENT PROGRAM

APPLICATION FOR SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SRSA APPLICATION

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

APPLICATION FOR SMALL RURAL SCHOOL ACHIEVEMENT PROGRAM

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SRSA APPLICATION

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

APPLICATION FOR SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SRSA APPLICATION

SEC. 9007 REAP-RENEW ENERGY SYS GRANTS (MAN)

APPLICATION FOR SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

APPLICATION FOR SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

APPLICATION FOR SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

APPLICATION FOR SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SEC. 9007 REAP-RENEW ENERGY SYS GRANTS (MAN)

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

APPLICATION FOR SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

TO SUPPORT A MULTIDISCIPLINARY SERIES OF ACTIVITIES EXPLORING THE HISTORY OF VANPORT, OR.

SEC. 9007 REAP-RENEW ENERGY SYS GRANTS (MAN)

SEC 9007 REAP-RENEW ENERGY SYSTEMS GRANTS, $20,000 OR LESS (MAN)

SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

INDIAN EDUCATION FORMULA GRANTS TO LEAS

APPLICATION FOR SMALL, RURAL SCHOOL ACHIEVEMENT PROGRAM

IN SUPPORT OF THE RECIPIENT'S PARTICIPATION IN THE ROLL-OUT OF POST'S SPEAKER PROGRAM ON URBAN PLANNING AND DISASTER MITIGATION. SPECIFICALLY THE RE

FORMULA GRANTS TO LEAS

INDIAN EDUCATION FORMULA GRANTS TO LEAS

SEC. 9007 REAP-RENEW ENERGY SYS GRANTS (MAN)

FORMULA GRANTS TO LEAS

INTEGRATIVE ONCOLOGY: FROM RESEARCH TO PRACTICAL APPLICATIONS

INDIAN EDUCATION FORMULA GRANTS TO LEAS

FORMULA GRANTS TO LEAS

SEC 9007 REAP-RENEW ENERGY SYSTEMS GRANTS, $20,000 OR LESS (MAN)

FORMULA GRANTS TO LEAS

UNKNOWN TITLE

UNKNOWN TITLE

UNKNOWN TITLE

INDIAN EDUCATION FORMULA GRANTS TO LEAS

FORMULA GRANTS TO LEAS

FORMULA GRANTS TO LEAS

FORMULA GRANTS TO LEAS

SEC 9007 REAP-RENEW ENERGY EFFICIENCY IMPROVE GRANTS, $20,000 OR LESS (MAN)

FORMULA GRANTS TO LEAS

SEC. 9007 REAP-RENEW ENERGY SYS GRANTS (MAN)

PET APOE & THE PRECLINICAL COURSE OF ALZHEIMER DISEASE

EAST ST. LOUIS HIV/AIDS SUBSTANCE ABUSE TRTMT. PROJECT FOR YOUNG AFRICAN AMERICAN

TANNER MEDICAL CENTER, INC. "NOW IS THE TIME" PROJECT AWARE-COMMUNITY

HEALTHY TOMORROWS PARTNERSHIP FOR CHILDREN PROGRAM

RURAL HEALTH CARE SERVICES OUTREACH GRANT PROGRAM

REAP RENEWABLE ENERGY SYSTEM (RES) GRANT UNRESTRICTED AMOUNT