Enso

DPA TITLE III - STATE-OF-THE-ART ONSHORE ADVANCED PACKAGING PRODUCTION (SOAPP)

DEVELOPMENT OF 270-280MM DEE ULTRAVIOLET LEDS

CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND - IHES

CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND - IHES

INFLATION REDUCTION ACT (IRA) – REMOTE EMISSIONS INVESTIGATION SYSTEM (REIS) THE GOAL OF THE PROJECT IS TO DEMONSTRATE THAT THE KUVA REMOTE EMISSIONS INVESTIGATION SYSTEM (REIS) CAN REDUCE IDENTIFIED, NON-ALLOWABLE METHANE EMISSIONS BY AN AVERAGE OF 95% OVER A PORTFOLIO OF 175 SITES RELATED TO OIL AND GAS PRODUCTION.

WASTEWATER SYSTEM REHAB

DISTRIBUTED SENSING TECHNOLOGIES FOR CIVIL INFRASTRUCTURE HEALTH MONITORING

ELECTROCHEMICAL PAPER-BASED ANALYTICAL DEVICES FOR METAL DETERMINATION

THE PURPOSE OF THE BIODIVERSITY CONSERVATION IN GUATEMALA (BCG) ACTIVITY IS TO CONSERVE THE BIODIVERSITY OF KEY PROTECTED AREAS IN GUATEMALA THROUGH LOCALLY LED ACTION AND THE IMPROVEMENT OF PROTECTED AREA MANAGEMENT AND GOVERNANCE.

THIS EDA INVESTMENT SUPPORTS THE TOWN OF BENSON WITH MAKING SEWER IMPROVEMENTS TO THE MINGO CREEK PUMP STATION, TO SERVE AN INDUSTRIAL AREA IN JOHNSTON COUNTY, NORTH CAROLINA. THE IMPROVEMENTS WILL SUPPORT THE EXPANSION OF THE BERRY GLOBAL MANUFACTURING FACILITY. BERRY GLOBAL, INC. IS AN ESSENTIAL BUSINESS, AND HAS PLAYED A KEY ROLE IN SUPPLYING MEDICAL AND CONSUMER PRODUCTS THROUGHOUT THE COVID-19 PANDEMIC. ONCE COMPLETED, THE PROJECT WILL PROMOTE ECONOMIC SUSTAINABILITY, EXPAND JOB OPPORTUNITIES, AND PROMOTE GROWTH AND RESILIENCY THROUGHOUT THE REGION.

PARENT-CHILD STEM LEARNING USING INTERACTIVE MEDIA.

BARCODED MAGNETIC BEADS FOR RAPID TESTS OF MRSA AND RESPIRATORY VIRAL PANELS

DESCRIPTION:THIS AGREEMENT PROVIDES FUNDING TO THE CITY OF STEVENSON, WASHINGTON TO IMPLEMENT ITS PROJECT TO UPGRADE ITS WASTEWATER TREATMENT PLANT AS DIRECTED IN THE 2022 CONSOLIDATED APPROPRIATIONS ACT.ACTIVITIES:THE ACTIVITIES TO BE PERFORMED INCLUDE THE EXECUTION AND IMPLEMENTATION OF A WASTEWATER INFRASTRUCTURE CONSTRUCTION PROJECT. WORK PLAN ACTIVITIES INCLUDING REPLACEMENT OF EXISTING HEADWORKS, SECONDARY TREATMENT EXPANSION AND ENHANCEMENTS, UV SYSTEM UPGRADES, REMODELING OF THE LAB/OPS BUILDING, AND VARIOUS CIVIL IMPROVEMENTS INCLUDING GRADING, GRAVEL AND ASPHALT SURFACING, FENCING, MINOR STORM WATER CONVEYANCE UPGRADES, AND A NON-POTABLE WATER PUMP STATION.SUBRECIPIENT:NO SUBAWARDS ARE INCLUDED IN THIS ASSISTANCE AGREEMENT.OUTCOMES:THE ANTICIPATED DELIVERABLES INCLUDE STARTUP OF NEW HEADWORKS, MIXERS, AERATION BASINS, PUMPS, DIFFUSERS, BLOWER BUILDING, UV CHANNELS 1 AND 2 AND GENERATOR. ADDITIONAL DELIVERABLES INCLUDE COMMISSIONING OF THE FINAL PLANT, COMPLETION OF THE LAB BUILDING, AND SITE IMPROVEMENTS. THESE IMPROVEMENTS WILL ALLOW THE CITY TO BE IN COMPLIANCE WITH EXISTING WATER QUALITY PERMIT REGULATIONS AND ACCOMMODATE FUTURE FLOWS TO MEET CAPACITY NEEDS OF THE RESIDENTS OF STEVENSON.

NOVEL APPROACHES FOR TAU PROTAC DRUG DISCOVERY - NOVEL APPROACHES FOR TAU PROTAC DRUG DISCOVERY ALZHEIMER’S DISEASE (AD), FRONTOTEMPORAL DEMENTIA (FTD), PROGRESSIVE SUPRANUCLEAR PALSY (PSP) ARE A GROUP OF NEURODEGENERATIVE DISEASES CHARACTERIZED BY THE PATHOLOGICAL ACCUMULATION OF HYPER-PHOSPHORYLATED TAU (P-TAU) PROTEIN, IN THE FORM OF INTRACELLULAR PAIRED HELICAL FILAMENTS (PHFS) OR NEUROFIBRILLARY TANGLES (NFTS), OR AGGREGATES, WITHIN NEURONS AND GLIA OF AFFECTED BRAIN REGIONS, LEADING TO CELL DEATH. SEVERAL APPROACHES TO REMOVE AGGREGATES OF PATHOGENIC TAU HAVE FAILED, INCLUDING ANTIBODY THERAPY. NOVEL APPROACHES TO REMOVE AGGREGATED PROTEINS ARE DESIRED. TARGETED PROTEIN DEGRADATION BY PROTEOLYSIS TARGETING CHIMERAS (PROTACS) HAS EMERGED AS NOVEL THERAPEUTIC MODALITY. PROTACS ARE HETEROBIFUNCTIONAL SMALL MOLECULES THAT SIMULTANEOUSLY BIND TO A TARGET PROTEIN AND A UBIQUITIN E3 LIGASE, THEREBY LEADING TO UBIQUITINATION AND SUBSEQUENT DEGRADATION OF THE TARGET. THEY PRESENT A NEW OPPORTUNITY TO MODULATE PROTEINS IN A MANNER INDEPENDENT OF ENZYMATIC OR SIGNALING ACTIVITY. PROTAC DRUGS OFFER MANY ADVANTAGES, SUCH AS: 1) TARGET CAN BE SELECTIVELY DEGRADED WITH CATALYTIC SPECIFICITY; 2) WEAK BINDERS CAN BE CONVERTED INTO SELECTIVE PROTAC DRUGS; 3) OVEREXPRESSED OR MUTANT TARGETS CAN BE DEGRADED; AND 4) LIMITED TARGET ENGAGEMENT CAN LEAD TO MAXIMAL DEGRADATION. ALTHOUGH MOST MISFOLDED AND AGGREGATED PROTEINS IN THE HUMAN PROTEOME CAN BE DEGRADED BY PROTEASOMAL SYSTEM, SOME NATIVE AND MUTANT PROTEINS PRONE TO AGGREGATION, SUCH AS TAU OLIGOMERS ARE RESISTANT TO ALL KNOWN PROTEOLYTIC PATHWAYS THUS SUBJECT TO AUTOPHAGIC OR LYSOSOMAL PATHWAY. DEVELOPMENT OF PROTACS THAT CAN EFFICIENTLY DEGRADE PATHOGENIC TAU AGGREGATES IS AN ATTRACTIVE AND BREAKTHROUGH THERAPY FOR AD AND FTD. NO ONE, INDUSTRY OR ACADEMIA HAS SHOWN CREDIBLE DATA FOR TAU PROTACS TO SUCCEED IN THE CLINIC. TRADITIONAL METHODS FOR PROTAC ANALYSIS, WESTERN BLOT OR REPORTER GENE ANALYSIS ARE TIME CONSUMING, CUMBERSOME, AND PRONE TO ARTIFACTS. IN THIS PROPOSAL WE DESCRIBE A HIGH THROUGHPUT METHOD FOR RAPID DEVELOPMENT OF TAU PROTACS. DEVELOPMENT OF PROTACS THAT PROMOTE TAU DEGRADATION BY LYSOSOMAL/AUTOPHAGIC MECHANISM IS CHALLENGING. THIS GRANT PROPOSES STRATEGIES TO SCREENING DIFFERENT E3 UBIQUITIN LIGASES FOR TAU PROTAC THAT WILL REMOVE PATHOGENIC (MONOMERIC) AS WELL AS AGGREGATES THROUGH AUTOPHAGIC MECHANISM. GOAL OF THE PROJECT IS TO ESTABLISH RULES THAT GOVERN PATHOGENIC TAU DEGRADATIONS, SUCH AS POLY-UBIQUITIN SIGNATURES CONJUGATED ON TAU AGGREGATES TO DIFFERENTIATE PROTEASOMAL VS LYSOSOMAL DEGRADATION. DEVELOPMENT OF THE TECHNOLOGY THAT DEGRADES TAU AGGREGATES CAN BE DIRECTLY APPLIED TO PARKINSON’S DISEASE, HUNTINGDON DISEASE AND AMYOTROPHIC LATERAL SCLEROSES.

SELF-SENSING SELF-SUSTAINING CARBON FIBER-REINFORCED POLYMER (S4CFRP) COMPOSITES FOR NEXT-GENERATION VEHICLES

WASTE DISPOSAL GRANTS - REGULAR

DEVELOPMENT OF AN OPEN SPEECH SIGNAL PROCESSING PLATFORM

COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - CONSTRUCTION

ENZYMATIC TRANSDERMAL ALCOHOL BIOSENSOR

DEVELOPMENT OF HIGH-OUTPUT, LOW-INPUT ENERGY BEETS

SBIR FAST TRACK: DEVELOPMENT OF A HIGH-THROUGHPUT MAGNETIC CYTOMETER FOR SINGLE CELL SORTING - PROJECT SUMMARY THIS SMALL BUSINESS INNOVATION RESEARCH PROJECT AIMS TO DEVELOP A HIGH-THROUGHPUT EASY-TO-USE CELL SORTER MAGICYTE™ TO RAPIDLY AND PRECISELY SORT INTACT AND VIABLE RARE CELLS AT SINGLE-CELL RESOLUTION. SINGLE-CELL SORTING FROM A HETEROGENEOUS CELL POPULATION HAS BEEN ESSENTIAL TO LIFE SCIENCE APPLICATIONS SUCH AS MONOCLONAL ANTIBODY PRODUCTION AND CELL LINE DEVELOPMENT. RECENTLY, WITH THE RAPID GROWTH OF PRECISION MEDICINE, THERE HAS ALSO BEEN A STRONG DEMAND FOR SINGLE-CELL SORTING TECHNOLOGIES FOR RARE CELLS, SUCH AS CIRCULATING TUMOR CELLS (CTCS), CIRCULATING FETAL CELLS, STEM CELLS AND ANTIGEN-SPECIFIC T- OR B-CELLS. HOWEVER, COLLECTING SUCH RARE CELLS AT SINGLE-CELL RESOLUTION TO MEET THE REQUIREMENTS OF SINGLE-CELL ANALYSIS IS NOT FEASIBLE FOR CONVENTIONAL SINGLE-CELL SORTING TECHNIQUES. MICROMANIPULATION AND SERIAL DILUTION ARE TIME CONSUMING AND LOW-THROUGHPUT, WHILE FLUORESCENT-ACTIVATED CELL SORTING (FACS) SUFFERS FROM REMARKABLE CELL LOSS AND IS INEFFICIENT IN ISOLATING RARE CELLS. IN ADDITION, MANY SUCH TECHNIQUES REQUIRE CELL FIXATION AND/OR FLUORESCENT STAINING, WHICH DECREASES CELL VIABILITY AND THUS PROHIBITS MANY DOWNSTREAM MOLECULAR ANALYSES, AS WELL AS AND CELL CULTURE. AS SUCH, THERE IS AN UNADDRESSED NEED FOR HIGH THROUGHPUT SINGLE-CELL SORTING OF RARE CELLS. WE AIM TO DEVELOP A HIGH-THROUGHPUT CHIP-BASED CYTOMETER MAGICYTE™ TO RAPIDLY ISOLATE, IDENTIFY AND SORT SINGLE INTACT AND VIABLE TARGET CELLS FROM HETEROGENEOUS CELL POPULATION. THE CORE COMPONENT OF MAGICYTE IS A SEMICONDUCTOR CHIP MAGICHIP™ WHICH IS USED FOR SINGLE CELL IDENTIFICATION AND SINGLE CELL SORTING. IN THIS FAST- TRACK PROJECT, WE WILL FIRST DEVELOP THE CONTROL SOFTWARE AND DEMONSTRATE AUTOMATED SINGLE-CELL SORTING; IN PHASE II, WE WILL DEVELOP THE NEXT-GENERATION MAGICHIP, BUILD THE MAGICYTE BETA PRODUCT AND VALIDATE THE SYSTEM ON CLINICAL SAMPLES WITH OUR COLLABORATORS.

A DRUG DISCOVERY PLATFORM TO PRIORITIZE DEVELOPMENT OF NATURAL PRODUCT NEUROMODULATORS FOR TREATING COGNITIVE IMPAIRMENT - PROJECT SUMMARY MILD COGNITIVE IMPAIRMENT (MCI) IS ONE OF THE EARLIEST AND MOST NOTICEABLE SYMPTOMS ASSOCIATED WITH ALZHEIMER’S DISEASE (AD) AND OTHER AD RELATED DEMENTIAS (ADRD). THERE IS NO CURE FOR ADRD, AND CONVENTIONAL TREATMENTS ONLY TARGET MORE DISEASE STAGES. NOTABLY, MCI ASSOCIATED WITH AD TYPICALLY OCCURS AFTER AD BIOMARKERS (RELATED TO Β-AMYLOID AND TAU PATHOLOGIES) ARE DETECTABLE IN PATIENTS, CREATING A NARROW WINDOW PRIOR TO MCI-AD ONSET AND DIAGNOSIS, TERMED PRECLINICAL AD, WHERE INTERVENTIONS SLOWING MCI ONSET HAVE THE POTENTIAL TO GREATLY IMPROVE PATIENT QUALITY OF LIFE AND DRAMATICALLY REDUCE COSTS OF AD CARE AT LARGE. HOWEVER, DEVELOPING PHARMACEUTICAL TREATMENTS FOR PRECLINICAL AD MUST MEET HIGH SAFETY MARGINS GIVEN THE DURATION OF TREATMENT, AND PAST ATTEMPTS HAVE FAILED TO SHOW EFFICACY. RECENTLY, APPROVALS OF ANTIDEPRESSANTS LIKE KETAMINE AND BREXANOLONE (BOTH 2019) AND THE RESURGENCE OF PSYCHEDELIC RESEARCH HAS HIGHLIGHTED THE POWER OF NEUROPLASTICITY MODIFIERS – COMPOUNDS DRIVING THE CREATION OR MODULATION OF SYNAPTIC CONNECTIONS WITHIN THE BRAIN – FOR MODIFYING NEUROLOGICAL FUNCTION TO IMPACT MENTAL HEALTH. ENGAGING NEUROPLASTICITY MECHANISMS THROUGH PHARMACOLOGICAL MEANS OR HOLISTIC APPROACHES (I.E. EXERCISE & DIETARY CHANGES) HAS BEEN SHOWN TO POSITIVELY ENHANCE COGNITION AND MEMORY. NOTABLY, SOME OF THE MOST POTENT NEUROPLASTICITY MODULATORS ARE NATURAL PRODUCTS (NPS) DERIVED FROM MEDICINAL PLANTS AND HERBS USED BY HUMANS FOR CENTURIES. AS SUCH, NPS HAVE BEEN THE SUBJECT OF NUMEROUS STUDIES INVESTIGATING THEIR POTENTIAL TO IMPROVE COGNITION AND PROGRESSION TO MCI IN AD. HOWEVER, INCOMPLETE DESCRIPTIONS OF NP MOLECULAR TARGETS, MECHANISMS OF ACTION, STABILITY, PURITY, POTENCY AND BIOAVAILABILITY HAVE LARGELY PREVENTED THEIR DEVELOPMENT AS CLINICAL DRUG CANDIDATES. WHAT’S MORE, THE QUANTITY OF KNOWN NPS FOUND IN BOTANICAL PRODUCTS NUMBERS IN THE TENS OF THOUSANDS. TO IDENTIFY AND DEVELOP PSYCHOACTIVE NATURAL PRODUCTS THAT IMPACT NEUROPLASTICITY AND CAN SLOW MCI ONSET, SENSORIUM THERAPEUTICS IS EXPANDING THE CAPACITY OF THEIR BIODYNAMIC DISCOVERY PLATFORMTM (BDP). OUR NOVEL BDPTM LEVERAGES AI-ASSISTED ANALYSIS OF ETHNOBOTANICAL DATA AND MEDICINAL CHEMISTRY COUPLED WITH IN VITRO HIGH-THROUGHPUT SCREENING USING HUMAN IPSCS TO PROVIDE AN EFFECTIVE DRUG DEVELOPMENT PIPELINE FOR IDENTIFYING NOVEL NPS AS MCI-AD TREATMENTS. OUR PLATFORM HAS ALREADY LED TO THE IDENTIFICATION OF A LEADING NATURAL PRODUCT DRUG CANDIDATE FOR DEPRESSION AND ANXIETY. ADDITIONALLY, WE HAVE IDENTIFIED A CLASS OF BOTANICALLY-DERIVED ALKALOID COMPOUNDS THAT HAVE FAVORABLE CNS PHARMACOLOGICAL PROFILES, EXCELLENT CHEMICAL AND IN VITRO SAFETY, AND ARE LINKED TO IMPROVING COGNITIVE FUNCTION IN HUMANS. THE OVERARCHING GOAL OF THIS FAST TRACK PROPOSAL IS TO EXPAND OUR BDPTM TO INCLUDE SCALABLE CELLULAR/NEURONAL READOUTS OF NEUROPLASTICITY WHILE INCORPORATING MCI-AD IN VITRO MODELS (PHASE I) AND IDENTIFY AND VALIDATE NP CANDIDATE EFFICACY FOR MCI-AD TREATMENT (PHASE II). SUCCESSFUL COMPLETION OF THIS FAST TRACK PROJECT WILL GENERATE NP CANDIDATES FOR FURTHER DEVELOPMENT AND DEMONSTRATE EFFICACY FOR SENSORIUM’S BIODYNAMIC DISCOVERY PLATFORMTM IN IDENTIFYING LEAD CANDIDATES FOR MCI-AD TREATMENTS.

INFLATION REDUCTION ACT EMBAJADORES DE LOS ARBOLES SEMBRANDO EL FUTURO

NEW AWARD PROJECT TITLED: "STAND ALONE BATTERY THERMAL MANAGEMENT SYSTEM"

HEAT VIZ: AN INTERACTIVE DIGITAL PLATFORM FOR HEAT ISLAND INVESTIGATIONS FOR K-12 STEM STUDENTS - PROJECT SUMMARY/ABSTRACT EXTREME HEAT IS THE LEADING CAUSE OF WEATHER-RELATED DEATHS IN THE UNITED STATES (MORE THAN HURRICANES AND TORNADOES COMBINED), AND THE HEAT ISLAND EFFECT INTENSIFIES THESE HEALTH RISKS, OFTEN IN LOW-RESOURCE URBAN AREAS. OUR RESEARCH TEAM HAS PREVIOUSLY PILOTED HEAT ISLAND MEASUREMENT PROJECTS FOR CITIZEN SCIENCE RESEARCH INVOLVING COLLEGE STUDENTS AND AS STEM LEARNING EXPERIENCES AT THE HIGH SCHOOL LEVEL. THROUGH THE PILOT PROJECTS, OUR TEAM HAS IDENTIFIED KEY USABILITY HURDLES THAT LIMIT THE WIDE-SPREAD SCALABILITY AND APPLICABILITY OF THESE ACTIVITIES. THIS SBIR FAST-TRACK PHASE I/II PROPOSAL (CALLED HEAT VIZ) AIMS TO BUILD AND TEST AN INTERACTIVE DIGITAL MEDIA PLATFORM TO ENABLE HEAT ISLAND PROJECTS TO BE IMPLEMENTABLE BY HIGH SCHOOLS ACROSS THE COUNTRY. THE GOAL OF THE PROJECT IS FOCUSED ON IMPROVEMENTS OF FOUR STUDENT OUTCOMES 1. CONTENT KNOWLEDGE OF RELEVANT DISCIPLINARY CORE IDEAS AROUND WEATHER, CLIMATE, BIOGEOLOGY, AND HUMAN IMPACTS ON THE EARTH 2. INCREASED PROFICIENCY WITH THE SCIENTIFIC AND ENGINEERING PRACTICES: PLANNING AND CARRYING OUT INVESTIGATIONS, ANALYZING AND INTERPRETING DATA, AND ARGUING FROM EVIDENCE 3. IMPROVED UNDERSTANDING OF THE HEALTH-RISKS OF HEAT ISLANDS, HOW THESE ARE INEQUITABLY DISTRIBUTED AMONG DIFFERENT GROUPS, AND WHAT MIGHT BE DONE TO ADDRESS THESE RISKS 4. INCREASED STUDENT INTEREST IN STEM AND EFFICACY ABOUT HOW STEM CAN IMPROVE THE LIVES OF THEMSELVES AND THEIR COMMUNITIES THE COMMERCIAL OUTCOME OF THE HEAT VIZ PROJECT WOULD BE TO CREATE A PROGRAM THAT INTEGRATES SENSORS, SOFTWARE, LESSON MATERIALS, AND PROFESSIONAL DEVELOPMENT INTO A MODULAR INSTRUCTIONAL UNIT THAT EDUCATORS CAN IMPLEMENT INTO THEIR BIOLOGY OR EARTH SCIENCE CURRICULUM. POCKETLAB WILL MARKET AND SELL THE HEAT VIZ PROGRAM THROUGH OUR ONLINE STORE AND THROUGH OUR NETWORK OF 30+ RESELLERS IN THE US AND INTERNATIONALLY. POCKETLAB WILL DISSEMINATE THE RESEARCH FINDINGS AND MARKET THE HEAT VIZ PROGRAM THROUGH OUR SCIENCE IS COOL LEARNING COMMUNITY WHICH HAS ENGAGEMENTS WITH 100K+ SCIENCE EDUCATORS.

LARGE-AREA PLASMA PANEL DETECTORS FOR PARTICLE BEAM RADIATION THERAPY

ULTRAFAST AND PRECISE EXTERNAL BEAM MONITOR FOR FLASH AND OTHER ADVANCED RADIATION THERAPY MODALITIES - SUMMARY/ABSTRACT FLASH RADIOTHERAPY (FLASH-RT) IS A NOVEL FORM OF RADIATION THERAPY THAT PROMISES LARGE SPARING OF NORMAL- TISSUES IN CANCER TREATMENT WHILE SHOWING NO TUMOR SPARING. IN FLASH-RT, THE RADIATION DOSE IS DELIVERED TO THE TUMOR AND NORMAL TISSUES IN MILLISECONDS RATHER THAN MINUTES. FLASH-RT IS ONLY EFFECTIVE WHEN GIVEN WITH LARGE DOSES PER FRACTION DELIVERED IN 1-3 TREATMENT SESSIONS. IT WOULD SHORTEN A STANDARD 30-DAY TREATMENT TO 1- 3 DAYS, THUS GREATLY REDUCING SIDE-EFFECTS AND RADIATION THERAPY COSTS TO BOTH THE PATIENT AND SOCIETY. THE FIRST HUMAN PATIENT WAS SUCCESSFULLY TREATED IN 2018. THE FIRST CLINICAL TRIAL WITH TEN (10) PATIENTS STARTED IN THE U.S. IN NOVEMBER 2020. ADDITIONAL CLINICAL TRIALS ARE PLANNED FOR 2021 IN THE U.S. AND IN EUROPE WITH AT LEAST 100 PATIENTS. A MAJOR LIMITATION OF FLASH-RT, PREVENTING A FAST TRANSLATION TO CLINICAL USE, IS THE LACK OF DETECTORS CAPABLE OF MEETING THE REQUIREMENTS NEEDED TO MONITOR AND TERMINATE THE FLASH-RT TREATMENT IN REAL TIME. WE PROPOSE TO DEVELOP AND DEMONSTRATE A LARGE AREA, ULTRAFAST AND PRECISE EXTERNAL BEAM MONITOR FOR FLASH-RT, UNIVERSALLY SUITABLE FOR ELECTRONS, PROTONS, PHOTONS, AND IONS, THAT CAN TERMINATE THE BEAM IN =1 MS WHILE THE PATIENT IS BEING TREATED. FOR THIS PROPOSAL, WE WILL PRIMARILY FOCUS ON DEVELOPING AND DEMONSTRATING THE SYSTEM FOR ELECTRON FLASH-RT WITH LINACS AND PROTON FLASH-RT WITH EXISTING CYCLOTRONS, BUT WILL ALSO DEMONSTRATE PERFORMANCE USING X-RAYS. UNLIKE STRIP OR WIRE IONIZATION CHAMBERS, THE PROPOSED SYSTEM IS BASED ON OUR PATENTED (JAN 2020 AND NOV 2020) IONIZING-RADIATION BEAM MONITORING SYSTEM TECHNOLOGY, WHICH CAN PROVIDE ULTRAFAST READOUT WITH CONCURRENT ANALYSIS OF THE RADIATION BEAM POSITION, PROFILE, AND FLUENCE/DOSIMETRY IN REAL TIME AT A RATE OF =10 KHZ (I.E., BEAM ANALYSIS =100 ΜS). THE PROPOSED SYSTEM PROVIDES REAL-TIME DOSIMETRY, BEAM CONTROL, AND VERIFICATION FOR FLASH-RT. IT PROVIDES AN ACCURATE 2D POSITION AND BEAM PROFILE OF RAPIDLY SCANNED BEAMS WITH A SPATIAL RESOLUTION OF A FEW MICRONS OVER AN ACTIVE BEAM MONITORING AREA OF 26 CM X 30 CM. THE BEAM MONITOR RESPONSE IS LINEAR, WITHOUT SATURATION, FOR ALL FLASH-RT BEAM LUMINOSITIES. PROTON BEAM TESTING WILL BE PRIMARILY AT THE UNIVERSITY OF MICHIGAN ION BEAM LABORATORY, AND ELECTRON BEAM TESTING AT THE NOTRE DAME RADIATION LABORATORY. THE PROPOSED PROGRAM IS FOR 3-YEARS AND WILL EVOLVE FROM FABRICATION AND TESTING OF A QUARTER-SCALE BEAM MONITOR IN YEAR 1 TO A FULL-SIZE SYSTEM WITH SELF-CALIBRATION CAPABILITY IN YEAR 3. OUR PRINCIPAL COLLABORATORS ON THIS PROGRAM INCLUDE THE UNIVERSITY OF MICHIGAN, PHYSICS DEPARTMENT, AND LOMA LINDA UNIVERSITY, SCHOOL OF MEDICINE. THE PROPOSED BEAM MONITOR CONSTITUTES A CRITICAL ENABLING TECHNOLOGY FOR ALL TYPES OF FLASH-RT. IT WILL ENSURE THE SAFETY, QUALITY, AND EFFICIENCY OF FLASH RADIATION THERAPY, ALLOWING CANCER PATIENTS TO BE SUCCESSFULLY TREATED WITH MUCH HIGHER DOSES, FEWER SIDE-EFFECTS, AND EXCELLENT TUMOR CONTROL. IT IS ALSO SUITABLE FOR SPATIALLY FRACTIONATED RADIATION THERAPY TECHNIQUES SUCH AS GRID, LATTICE, MICROBEAM RT (MRT), AND PROTON-MINIBEAM RT (PMBRT). THE PROPOSED BEAM MONITOR IS ALSO BEING DESIGNED INTO A NOVEL (PATENT PENDING) ULTRAFAST RADIOABLATION SYSTEM THAT ELIMINATES THE MOTION PROBLEM FOR TREATING CARDIAC ARRHYTHMIA (AFIB). OMB NO. 0925-0001/0002 (REV. 01/18 APPROVED THROUGH 03/31/2020) PAGE CONTINUATION FORMAT PAGE

SBIR PHASE II: DEVELOPING A CONTINUOUS, WIRELESS, INTRA-ORAL SALIVARY PH SENSOR -THE BROADER IMPACT/COMMERCIAL POTENTIAL OF THIS SMALL BUSINESS INNOVATION RESEARCH (SBIR) PHASE II PROJECT IS TO MANAGE THE RISK OF TOOTH DECAY, OR CARIES DISEASE, THE WORLD?S MOST PREVALENT CHRONIC CONDITION. TOOTH DECAY RESULTS IN SEVERE PAIN, DEVASTATING FINANCIAL ISSUES, LOST WORK, LOSS OF CONFIDENCE, EMBARRASSMENT FROM APPEARANCE AND SPEECH, AND BROAD SYSTEMIC HEALTH PROBLEMS. IT DISPROPORTIONATELY AFFECTS MINORITIES AND LOWER-INCOME INDIVIDUALS. CONTROLLING ACID LEVELS OF HIGH-RISK PATIENTS IS AN EFFECTIVE DECAY PREVENTION STRATEGY. AN ORAL ACIDITY MONITOR FOR CARIES PREVENTION WILL ALLOW PATIENTS AT HIGH RISK OF CARIES DISEASE TO RECEIVE ALERTS TO NEUTRALIZE INTRAORAL ACIDITY BEFORE IT CAUSES PERMANENT DAMAGE, AND WORK MORE EFFECTIVELY WITH THEIR DENTISTS TO FOLLOW AND EVALUATE THE EFFECTIVENESS OF PRESCRIBED CARIES PREVENTION PROTOCOLS. THIS SMALL BUSINESS INNOVATION RESEARCH (SBIR) PHASE II PROJECT FOCUSES ON THE COMMERCIALIZATION OF THE WORLD?S FIRST CONTINUOUS INTRAORAL ACIDITY MONITOR. THIS PROJECT ADVANCES SENSORS PROVIDING LONG-TERM DATA READINGS OF SALIVARY PH AND ITS RESPONSE TO ENVIRONMENTAL CONDITIONS. AS A PLATFORM TECHNOLOGY, INTRAORAL SENSORS HAVE MORE APPLICATIONS IN A BROAD RANGE OF MARKETS IN ADDITION TO DENTAL CARIES; FUTURE SENSORS INCLUDE SODIUM AND POTASSIUM MONITORS FOR HEART DISEASE, HYPERTENSION, AND RENAL FAILURE, AND GLUCOSE MONITORS FOR DIABETES. LONG-TERM PLANS INCLUDE BIOLOGIC SENSING SUCH AS ALLERGEN, VIRAL LOAD, AND DRUG COMPLIANCE MONITORS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

PERFORM FUNDING SYS

UBIQUITIN PROTEASOME SYSTEM AND MOLECULAR SIGNATURES OF ALZHEIMER'S DISEASE

STACKED MINIATURIZED AND RADIATION TOLERANT INTELLIGENT ELECTRONICS (SMARTIE)

RATIONAL DESIGN OF BIFUNCTIONAL PROTEIN DEGRADER DRUGS - UBIQUITIN (UB) TAGS REGULATE MULTIPLE PROPERTIES AND FUNCTIONS OF PROTEINS IN CELLS. PROTEASOMAL DEGRADATION OF TARGET PROTEINS IS A WELL-ESTABLISHED MEANS WHEREBY THE UB PROTEASOME SYSTEM (UPS) CONTROLS PROTEIN CONTENT. ENZYMES CALLED UB E3 LIGASES CONJUGATE UB TO TARGET PROTEINS BY FORMING AN ISOPEPTIDE BOND BETWEEN THE E- AMINO GROUP OF THE TARGET PROTEIN LYSINE AND THE CARBOXYLATE OF THE C-TERMINAL GLYCINE OF UB. CONJUGATION OF MULTIPLE UBS FORMS POLY-UB CHAINS AT ANY OF ITS SEVEN LYSINES (K), AND K6, K11, K27, K29, K33, K48, AND K63 UB CHAINS HAVING VARIOUS ROLES ARE PRESENT IN ALL TISSUES. RECENTLY, SEVERAL GROUPS DESIGNED SMALL MOLECULES THAT BIND TO AN E3 LIGASE AT ONE END AND A TARGET PROTEIN AT THE OTHER, PHYSICALLY FACILITATING UBIQUITYLATION OF THE TARGET PROTEIN, WHICH IS THEN DEGRADED. THIS HIJACKING OF A LIGASE TO UBIQUITYLATE A DESIRED PROTEIN HAS LAUNCHED A NEW CLASS OF DRUG CALLED PROTACS (PROTEOLYSIS TARGETING CHIMERAS). PROTAC-BASED APPROACHES FOR THERAPEUTICS OFFER SEVERAL ADVANTAGES: 1) SELECTIVE, CATALYTIC DEGRADATION OF THE TARGET; 2) CONVERSION OF WEAK BINDERS INTO SELECTIVE PROTAC DRUGS; 3) DEGRADATION OF OVEREXPRESSED OR MUTANT TARGETS; AND 4) MAXIMAL DEGRADATION FROM LIMITED TARGET ENGAGEMENT. TO DATE, CEREBLON AND VHL LIGASE BINDERS HAVE BEEN MOST COMMONLY USED AS VEHICLES TO UBIQUITYLATE TARGET PROTEINS SUCH AS NUCLEAR RECEPTORS, KINASES, TRANSCRIPTION FACTORS, AND NEURONAL PROTEINS TAU AND A-SYNUCLEIN. A MAJOR PROBLEM HAS HINDERED DEVELOPMENT OF NEW PROTAC DRUGS, HOWEVER. CHEMICAL OPTIMIZATION OF PROTAC MOLECULES DEPENDS ON RAPID EVALUATION OF SYNTHESIZED COMPOUNDS TO GUIDE THE SYNTHETIC STRATEGY FOR PRODUCING DRUG CANDIDATE MOLECULES. ASSAYS CURRENTLY AVAILABLE ARE LABOR INTENSIVE AND DO NOT PROVIDE RESULTS TO THE MEDICINAL CHEMISTS FAST ENOUGH – OFTEN, A WEEK IS REQUIRED. IN PHASE I, A FACILE IN VITRO METHOD EMPLOYING UB LIGASES CEREBLON AND HDM2 WAS DEVELOPED TO SCREEN FOR POTENTIAL PROTAC DRUGS; PROTAC-MEDIATED UBIQUITYLATION OF SELECTED PROTEINS WAS RECAPITULATED IN VITRO IN A WAY THAT MIMICS OBSERVED PROTAC-DEPENDENT UBIQUITINATION AND DEGRADATION OF THESE PROTEINS IN VIVO, ACHIEVING THE AIMS OF PHASE I. IN PHASE II, THE UTILITY OF THIS METHOD WILL BE EXPANDED TO INCLUDE REPRESENTATIVE MEMBERS OF ALL UB LIGASE FAMILIES (CULLIN FAMILIES, RING FINGER LIGASES, HECT FAMILY LIGASES, AND SUMO LIGASE), INCREASING THE BIOCHEMICAL AND CHEMICAL SPACE FOR PROTAC DRUG DISCOVERY. TO SCALE UP PROTAC SCREENS, A MICROTITER PLATE-BASED, HIGH THROUGHPUT METHOD WILL BE ESTABLISHED TO MONITOR IN VITRO PROTAC DRUG DISCOVERY, AND BIOCHEMICAL AND UB MASS SPEC PROTEOMICS WILL BE EMPLOYED TO DEMONSTRATE THAT TARGET PROTEIN LYSINES UBIQUITYLATED IN VITRO ARE CORRELATED WITH IN VIVO PROTAC MEDIATED DEGRADATION OF TARGET PROTEINS. COMMERCIALIZATION OF THE MICROTITER PLATE BASED PROTAC SYSTEM WILL HAVE A MAJOR IMPACT ON ACADEMIC RESEARCH AS WELL AS PROTAC DRUG DISCOVERY.

HIGH PERFORMANCE SCINTILLATOR AND BEAM MONITORING SYSTEM

A WEARABLE SENSOR SYSTEM FOR HAND HYGIENE COMPLIANCE TRACKING

LAB-ON-A-CHIP-BASED SYSTEM FOR DETECTION AND MONITORING OF ORAL CANCER IN DENTAL SETTINGS

SELF POWERED WIRELESS SENSOR SYSTEM FOR POWER GENERATION APPLICATIONS

NANOTECHNOLOGY BASED MAGNETIC DETECTION FOR RARE CELL ASSAYS

CLOUD-BASED HIGH-THROUGHPUT ACQUISITION AND ANALYTICS OF ZEBRAFISH ELECTROCARDIOGRAM FOR CARDIAC STUDIES AND DRUG DEVELOPMENT

DEVELOPMENT OF 230-235 DEEP ULTRAVIOLET LEDS

CITIZEN-SCIENCE TECHNOLOGY FOR HEALTHY LIVING AT HOME - ABSTRACT HUMAN EXPOSURE TO AIR POLLUTION IS THE LEADING ENVIRONMENTAL RISK FACTOR FOR PREMATURE MORBIDITY AND MORTALITY WORLDWIDE AND, IN THE UNITED STATES (U.S.), PEOPLE OF COLOR SUFFER FROM MANY DISEASES ASSOCIATED WITH EXPOSURE TO AIR POLLUTION AT HIGHER RATES THAN WHITE PEOPLE. OUR UNDERSTANDING OF HUMAN EXPOSURE TO AIR POLLUTION IS BASED LARGELY ON MEASUREMENTS OF OUTDOOR POLLUTANT CONCENTRATIONS AND A MULTITUDE OF STUDIES HAVE FOUND THAT, FOLLOWING DECADES OF DISCRIMINATORY HOUSING AND LAND-USE POLICIES, PEOPLE OF COLOR ARE MORE LIKELY TO LIVE IN U.S. NEIGHBORHOODS WITH HIGHER CONCENTRATIONS OF OUTDOOR AIR POLLUTION; HOWEVER, OUTDOOR AIR POLLUTION DATA DO NOT CAPTURE THE FULL PICTURE OF HUMAN EXPOSURE. PEOPLE LIVING IN THE U.S. SPEND MOST OF THEIR TIME INDOORS AT HOME AND PRIOR STUDIES HAVE FOUND THAT IN-HOME AIR POLLUTANT CONCENTRATIONS—WHICH, BEING A COMBINATION OF POLLUTION FROM OUTDOOR AND INDOOR SOURCES, ARE ALSO LIKELY TO BE IMPACTED BY THE AFOREMENTIONED DISCRIMINATORY POLICIES— TEND TO BE BETTER-CORRELATED WITH PERSONAL EXPOSURES THAN OUTDOOR CONCENTRATIONS. IN-HOME AIR POLLUTION IS RARELY CHARACTERIZED DUE TO THE COST AND COMPLEXITY OF SETTING UP LARGE, NOISY, FINICKY MONITORS IN PRIVATE RESIDENCES. THE GOAL OF THIS PHASE II SBIR PROJECT IS TO REDUCE THE AMOUNT OF AIR POLLUTION U.S. RESIDENTS ARE EXPOSED TO AT HOME BY MAKING CHARACTERIZATION OF IN-HOME AIR QUALITY EASY; AFFORDABLE; USEFUL TO HOME OCCUPANTS; AND WIDESPREAD ENOUGH TO INFLUENCE LOCAL-, STATE-, AND NATIONAL-LEVEL POLICIES. THE FIRST AIM OF THIS PROJECT IS TO DEVELOP A SMALL, QUIET, EASY-TO-USE “HOME HEALTH BOX” (HHB) THAT MEASURES INDOOR CONCENTRATIONS OF PARTICULATE MATTER, VOLATILE ORGANIC COMPOUNDS, CARBON DIOXIDE, AND NITROGEN DIOXIDE USING A COMBINATION OF LOW-COST SENSORS AND HIGH-FIDELITY INTEGRATED SAMPLERS. THE HHB IS DESIGNED TO ELIMINATE THE NEED FOR AN AIR QUALITY PROFESSIONAL TO GO TO THE HOME; ONCE THE HHB IS DELIVERED, AN OCCUPANT SIMPLY NEEDS TO SET IT IN A CENTRAL LOCATION, PLUG IT IN, AND SWITCH IT ON. DATA COLLECTED BY THE HHB WILL UNDERGO AUTOMATED ANALYSES, BE REVIEWED BY AN AIR QUALITY PROFESSIONAL, AND THEN BE SYNTHESIZED INTO A REPORT THAT WILL (A) COMPARE MEASURED POLLUTANT LEVELS TO GUIDELINES, (B) DESCRIBE POTENTIAL POLLUTION SOURCES, AND (C) SUGGEST AFFORDABLE ACTIONS THAT OCCUPANTS COULD TAKE TO IMPROVE THEIR IN-HOME AIR QUALITY. THE SECOND AIM OF THIS PROJECT IS TO EVALUATE WHETHER HHB SAMPLING AND SUBSEQUENT RECEIPT OF A PERSONALIZED “HOME HEALTH REPORT” (HHR) HELPS HOUSEHOLDS IMPROVE THEIR IN-HOME AIR QUALITY OVER TIME. A RACIALLY- AND ETHNICALLY-DIVERSE GROUP OF HOUSEHOLDS WILL BE RECRUITED IN PARTNERSHIP WITH HEALTHCARE PROVIDERS AND COMMUNITY ORGANIZATIONS IN DENVER AND CHICAGO. HOMES WILL BE RANDOMIZED INTO INTERVENTION AND CONTROL GROUPS. HOMES IN BOTH GROUPS WILL RECEIVE THREE, ONE-WEEK HHB DEPLOYMENTS SPACED SIX WEEKS APART. AFTER EACH OF THE FIRST TWO DEPLOYMENTS, HOMES IN THE INTERVENTION GROUP WILL RECEIVE A HHR. WE WILL (A) INVESTIGATE WHETHER AND HOW AIR QUALITY CHANGES OVER TIME IN CONTROL AND INTERVENTION HOMES AND (B) SURVEY INTERVENTION HOUSEHOLDS ON THE UTILITY OF THE HOME HEALTH REPORTS. ALL HOMES WILL RECEIVE A HHR AT THE END OF THE STUDY.

LINKAGE-SPECIFIC UBIQUITYLATION PATTERNS AS HIGHLY SENSITIVE MARKERS FOR NEURODEGENERATIVE DISEASE

AN ACCURATE, FAST, AND MINIATURIZED GLUCOSE SENSOR FOR CLOSED-LOOP DIABETES MANAGEMENT

NEXT GENERATION TOOLS FOR ONSITE MONITORING AND TREATMENT OF DRUG OF ABUSE-DEPENDENT PERSONS

DEVELOPMENT OF LINKAGE-SPECIFIC UBIQUITIN BINDING ELEMENTS

DEVELOPMENT/COMMERCIALIZATION OF A SENSING DEVICE TO DETECT VAPING

MICROFLUIDIC NITRIC OXIDE SENSOR

THIS EDA AWARD SUPPORTS THE CITY OF BENSON'S CONSTRUCTION OF NEW FLOOD PROTECTION INFRASTRUCTURE THAT WILL ENHANCE THE RELIABILITY AND RESILIENCY OF CRITICAL WASTEWATER TREATMENT SERVICES DURING FUTURE NATURAL DISASTERS LIKE THOSE THAT AFFECTED THE CITY IN 2019. THE CITY'S EXISTING WASTEWATER TREATMENT (WWTP) FACILITY SITS ON THE CHIPPEWA RIVER. IN 2019, THE CITY FLOODED, AND WHILE THE WWTP FACILITY'S PROPERTY WAS FLOODED, THE PLANT ITSELF WAS NOT AFFECTED. AFTER YEARS OF CITY INVESTMENTS TO MOVE CRITICAL INFRASTRUCTURE OUT OF HARM'S WAY, THE WWTP FACILITY IS STILL UNPROTECTED AND VULNERABLE. THE EDA-FUNDED EARTHEN BERM WILL PROVIDE CRITICAL PROTECTION TO THE FACILITY DURING FUTURE FLOOD EVENTS, AND WILL ENSURE CRITICAL SERVICES REMAIN ONLINE AND RESILIENT IN THE FACE OF FUTURE ECONOMIC SHOCKS. THE ENHANCED PROTECTION PROVIDED BY THE NEW BERM ADDRESSES CONCERNS VOICED BY BUSINESS AND INDUSTRIAL USERS WHO RELY ON THE PLANT TO KEEP OPERATIONS RUNNING DURING DISASTER EVENTS, AND THE PROJECT IS EXPECTED TO CREATE 20 NEW JOBS AND GENERATE $60,000,000 IN PRIVATE INVESTMENT.

SBIR PHASE II: IN-LINE SENSOR FOR MONITORING MONOCLONAL ANTIBODY PRODUCTION BASED ON HYDROGELS CONTAINING PEPTIDE APTAMERS

TAS::89 0222::TAS; NEW SBIR PHASE I; TITLE: HIGH-PERFORMANCE PLASMA PANEL BASED MICROPATTERN DETECTOR; P.I.: DR. PETER FRIEDMAN;

IMPROVING THE HOST RESPONSE TO IMPLANTABLE GLUCOSE SENSORS VIA NITRIC OXIDE RELEASE

SBIR PHASE II: NATURAL LANGUAGE VOICE CONTROLLED SCIENCE EQUIPMENT

MICROWAVE THERMORELECTANCE IMAGER FOR CORROSION DETECTION AND MONITORING IN REINFORCED CONCRETE

PIPELINE SAFETY PROGRAM BASE G

RURAL HEALTH NETWORK DEVELOPMENT PROGRAM

COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - CONSTRUCTION - THE BOBBY BENSON CENTER WAS AWARDED $1.2 MILLION FROM THE UNITED STATES CONGRESS UNDER THE COMMUNITY FUNDED PROJECT PROGRAM AND SUBSEQUENTLY ARE NOW APPLYING TO THE HRSA-23-117 IN ORDER TO RECEIVE THE FUNDING DESIGNATED FOR THE CONGRESSIONAL AWARD. THE PROJECT BEING FUNDED IS THE BOBBY BENSON CENTER'S FACILITY RENOVATION PROJECT. THE BOBBY BENSON CENTER IS A NON-PROFIT RESIDENTIAL TREATMENT FACILITY FOR YOUTH AGES 13-17 YEARS OLD WITH SUBSTANCE USE AND MENTAL HEALTH DISORDERS. THE FACILITY CONSISTS OF FOUR CABINS (YOUTH LIVING QUARTERS AND THERAPIST OFFICES) WITH A COMBINED 8,000 SQUARE FEET AND A 3,600 SQUARE FOOT ADMINISTRATION BUILDING WHERE YOUTH PARTICIPATE IN THE INTAKE PROCESS, MEET WITH THE NURSE/OPERATIONS MANAGER/CLINICAL DIRECTOR/INTAKE COORDINATOR, AND ALSO HOUSES OUR ACCOUNTING, HUMAN RESOURCE, QUALITY ASSURANCE, AND IT DEPARTMENTS. OUR UPMOST PRIORITY AT THE BOBBY BENSON CENTER IS THE HEALTH (BOTH PHYSICAL AND MENTAL) & SAFETY OF THE YOUTH, EMPLOYEE, VISITORS AND OTHER CUSTOMERS. BOBBY BENSON CENTER HAS BEEN IN OPERATIONS FOR 33 YEARS AND IN THAT TIME THE BUILDINGS HAVE BEEN SUBJECT TO AGING, WEAR AND TEAR AND ENVIRONMENTAL ELEMENTS THAT HAVE MADE IT NECESSARY RENOVATE THE FACILITY. THIS FUNDING WILL HELP SUPPORT THE CENTER IN MAKING THE NECESSARY RENOVATIONS OF THE FACILITY TO ENSURE THAT ALL WHO ENTER MAY ENJOY A CLEAN AND MODERN FACILITY AND MAKE AN ENVIRONMENT CONDUCIVE TO HEALING FOR THE YOUTH.

SUMO FUSIONS TO ENHANCE EXPRESSION OF MEMBRANE PROTEINS

BIOMARKER DISCOVERY: UBIQUITIN PATHWAY PROTEIN MICROARRAYS

SEE SCHEDULE

SBIR PHASE II: REAL-TIME BIOSENSOR FOR MEASURING HAZARDOUS CHEMICAL CONTAMINANTS IN GROUND WATER

NOVEL POSITION-SENSITIVE PARTICLE TRACKING GAS DETECTOR

METAMATERIAL VOID SENSOR FOR FAST TRANSIENT TESTING

A POCKET-SIZED DEVICE FOR PERSONAL EXPOSURE LEVEL ASSESSMENT

SBIR PHASE II: MEASURING AQUEOUS METAL CONCENTRATIONS WITH THE CHEMOMETER

PUBLIC AND INDIAN HOUSING

PUBLIC AND INDIAN HOUSING

PUBLIC AND INDIAN HOUSING

PURPOSE: THE PUBLIC HOUSING OPERATING FUND (PH OPFUND) PROVIDES OPERATING SUBSIDIES TO HOUSING AUTHORITIES (HAS) TO ASSIST IN FUNDING THE OPERATING AND MAINTENANCE EXPENSES OF THEIR DWELLINGS, IN ACCORDANCE WITH SECTION 9 OF THE U.S. HOUSING ACT OF 1937, AS AMENDED. THE SUBSIDIES ARE REQUIRED TO HELP MAINTAIN SERVICES AND PROVIDE MINIMUM OPERATING RESERVES. THE PH OPFUND IS A $5 BILLION DOLLAR PROGRAM PROVIDING FUNDING TO APPROXIMATELY 6,000 HAS SERVING 1,590,321 PUBLIC HOUSING RESIDENTS IN 902,436 HOUSEHOLDS (44% ARE ELDERLY AND 35% OF RESIDENTS HAVE CHILDREN). INFORMATION ON THE CURRENT OPERATING FUND GRANT PROCESSING CAN BE FOUND AT HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/PUBLIC_INDIAN_HOUSING/PROGRAMS/PH/AM/FUNDING.; ACTIVITIES TO BE PERFORMED: OPERATING FUNDS ARE USED TO FUND DAY-TO-DAY OPERATIONAL EXPENSES ASSOCIATED WITH PUBLIC HOUSING AS WELL AS THE ADMINISTRATIVE AND PROGRAM IMPLEMENTATION EXPENSES THAT PUBLIC HOUSING AGENCIES (PHAS) ARE REQUIRED TO UNDERTAKE UNDER THE 1937 HOUSING ACT AND PROGRAM REGULATIONS. SUCH ACTIVITIES INCLUDE MANAGEMENT AND OPERATIONS, ROUTINE AND PREVENTATIVE MAINTENANCE, ANTI-CRIME, ANTI-DRUG AND SECURITY ACTIVITIES, OPERATING COSTS FOR PRIVATELY OWNED PUBLIC HOUSING UNITS WITHIN MIXED-FINANCE PROJECTS, ENERGY COSTS, RESIDENT SUPPORTIVE SERVICES, INSURANCE, DEBT SERVICE AND COSTS ASSOCIATED WITH ADMINISTRATION AND PROGRAM IMPLEMENTATION. TURNKEY III PROJECTS ARE FUNDED FOR UNITS UNDER THE FINAL LEASE PURCHASE AGREEMENT FOR CLOSING OUT THE PROGRAM. TO SUPPORT THESE ACTIVITIES, THERE IS CONTINUED MODERNIZATION OF THE INFORMATION TECHNOLOGY PLATFORMS. PHAS HAVE ACCESS TO WEB-BASED PLATFORMS THAT UTILIZE REAL-TIME DATA TO PROVIDE INSIGHT INTO THEIR PORTFOLIOS. PHAS CAN OBTAIN METRICS ON THEIR FUNDING LEVELS, OCCUPANCY RATES, AND THE NUMBER OF FAMILIES SERVED THROUGH RENTAL ASSISTANCE.; EXPECTED OUTCOMES: AS A RESULT OF THE ACTIVITIES PERFORMED, THIS PROGRAM IS EXPECTED TO ASSIST IN FUNDING THE OPERATING AND MAINTENANCE EXPENSES. THIS MAY INCLUDE INCREASED OCCUPANCY IN PUBLIC HOUSING, DECREASED ENERGY COSTS THROUGH REGULAR MAINTENANCE AND ENERGY PERFORMANCE CONTRACTING AND LEVERAGE FEDERAL RESOURCES. IN ADDITION TO ADDRESSING THE DEPARTMENT’S STRATEGIC GOALS OF: • ADDRESSING THE NEED FOR QUALITY AFFORDABLE RENTAL HOMES BY MAINTAINING OR IMPROVING UPON THE 96% OCCUPANCY RATE OF HABITABLE UNITS; • PROMOTING HOUSING AS A PLATFORM TO IMPROVE QUALITY OF LIFE THROUGH SUPPORTIVE SERVICES, CRIME PREVENTION EFFORTS AND RESIDENT ENGAGEMENT ACTIVITIES; AND • HELPING TO BUILD INCLUSIVE COMMUNITIES FREE FROM DISCRIMINATION BY FACILITATING THE IMPLEMENTATION OF AFFIRMATIVELY FURTHERING FAIR HOUSING MEASURES.; INTENDED BENEFICIARIES: THE OPERATING FUND PROVIDES FOR THE OPERATION AND MAINTENANCE OF LOW-INCOME HOUSING PROJECTS TO PHAS/PROJECTS. IT WAS CREATED TO ASSIST HOUSING AUTHORITIES IN PROVIDING DECENT AND SAFE RENTAL HOUSING FOR ELIGIBLE LOW-INCOME FAMILIES OR INDIVIDUALS, THE ELDERLY, AND PERSONS WITH DISABILITIES. A HA DETERMINES ELIGIBILITY BASED ON 1) ANNUAL GROSS INCOME; 2) A PERSON ON WHO IS ELDERLY, A PERSON WITH A DISABILITY, OR AS A FAMILY; AND 3) U.S. CITIZENSHIP OR ELIGIBLE IMMIGRATION STATUS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

PERFORM FUNDING SYS

SBIR PHASE II: DEEP UV LED WITH HIGH QUALITY P-ALINGAN LAYERS BY DIGITAL DOPING CONTROL

SBIR PHASE II: BIOLOGICAL TREATMENT OF HYDROCARBONS IN SHIPBOARD EXHAUST GAS CLEANING SYSTEMS

PUBLIC AND INDIAN HOUSING

SBIR PHASE II: HIGH RESOLUTION TERAHERTZ VIDEO CAMERA FOR MEDICAL IMAGING -THIS SMALL BUSINESS INNOVATION RESEARCH PHASE II PROJECT WILL DEVELOP AND LAUNCH A NEW, COMMERCIALLY VIABLE TERAHERTZ (THZ) IMAGING TECHNOLOGY INITIALLY TARGETED AT MEDICAL IMAGING APPLICATIONS. THE PROTOTYPE INSTRUMENT USES THZ REFLECTIVE IMAGING PHENOMENOLOGY, A TECHNIQUE THAT HAS BEEN SHOWN TO EFFICIENTLY DISCRIMINATE BETWEEN HEALTHY AND DISEASED TISSUES. WITH A RESOLUTION OF MORE THAN 300X300 PIXELS, OPERATION AT BETWEEN 10-30 FRAMES PER SECOND, AND A COMPACT FORM FACTOR, THE SYSTEM IS APPROPRIATE FOR MEDICAL ENVIRONMENTS SUCH AS CANCER SURGERIES, INCLUDING GLIOBLASTOMA RESECTION. THE THZ CAMERA WILL BE A NEW ADDITION TO THE MEDICAL IMAGING MARKET THAT HAS MATURED WITH X-RAY, MRI, VISIBLE AND INFRARED TECHNOLOGIES TO REACH $45 BILLION. THIS NEW INSTRUMENT IS ENABLED BY A LARGE FORMAT SENSOR ARRAY THAT USES A LOW-COST MANUFACTURING PROCESS ALREADY IMPLEMENTED IN A HIGH-VOLUME FOUNDRY. IN ADDITION TO THE MEDICAL APPLICATION, SIMILAR IMAGING SYSTEMS CAN BE USED IN SECURITY SCREENING APPLICATIONS ($2 BILLION MARKET/YEAR) SUCH AS PASSENGER SCREENING AT AIRPORTS. MORE BROADLY, THE UNDERLYING SENSOR TECHNOLOGY CAN BE ADAPTED FOR USE ACROSS THE EXTREMELY WIDE THZ SPECTRUM, WHICH HAS IMPLICATIONS FOR MANY INDUSTRIES. THE INTELLECTUAL MERIT OF THIS PROJECT IS PRIMARILY ITS INTEGRATION OF BOTH HIGH RESOLUTION AND HIGH-SPEED ASPECTS OF THZ IMAGING, AS THESE CAPABILITIES HAVE NOT YET BEEN DEMONSTRATED IN A COMMERCIALLY VIABLE FORM. PREVIOUS DEMONSTRATIONS HAVE EITHER INVOLVED SLOW SCANNING SYSTEMS THAT PRECLUDE REAL TIME APPLICATIONS OR CAMERAS THAT TARGET MUCH HIGHER BANDS OF THE THZ SPECTRUM. THE LATTER RESTRICTION STEMS FROM AN INABILITY TO MANUFACTURE ARRAYS OF LARGE PIXELS TO IMAGE AT THE LONGER THZ WAVELENGTHS. GOING BEYOND ONE OF A KIND LABORATORY PROOF OF CONCEPT EXPERIMENTS, THE THZ CAMERA SEEKS TO PROVIDE RESOLUTION AND FRAME UPDATE RATES THAT ARE RELEVANT TO ACTUAL APPLICATIONS. THE COMMERCIAL MANUFACTURING VIABILITY OF THE SENSING ELEMENT MAY ENSURE THAT APPLICATIONS BEYOND THE INITIAL MEDICAL MARKET WILL BE PRACTICAL. THE CAMERA WILL FEATURE NOT ONLY THE HIGH-RESOLUTION THZ IMAGING NEAR THE 250-350 GHZ SPECTRUM BUT ALSO INCORPORATE HIGH-RESOLUTION VISIBLE AND NEAR-INFRARED CAMERAS THAT CAN COMPLEMENT THE THZ VIDEO, WITH TRIALS BEING PLANNED FOR HOSPITAL USAGE. IN ADDITION TO CLINICAL USAGE SCENARIOS, THE IMAGING SYSTEM CAN BE ADAPTED FOR USE IN AIRPORT SECURITY AND OTHER SCREENING APPLICATIONS, AS PORTABILITY AND EASE OF USE WILL GUIDE THE DEMONSTRATION SYSTEM DESIGN. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

N5 SENSORS, INC.: NEW SENSOR-SBIR AWARD. CONTROL NUMBER: 1738-1524 TITLE: ''A DIGITAL SYSTEM-ON-CHIP CO2 SENSOR'' THE N5 SENSORS, INC. WILL DESIGN, DEMONSTRATE AND COMMERCIALIZE A DIGITAL SYSTEM-ON-CHIP (SOC) CO2 SENSOR TECHNOLOGY THAT WILL ENABLE THE ARPA-E SENSOR PROGRAM’S GOAL OF 30% REDUCTION IN ENERGY USE IN COMMERCIAL AND RESIDENTIAL BUILDINGS. ----------

CONSOLIDATED PROGRAM FOR RESEARCH AND DEVELOPMENT OF DEFECT DETECTION/CHARACTERIZATION

DESCRIPTION:THIS ACTION PROVIDES FUNDING IN THE AMOUNT OF $1,000,000 TO THE TOWN OF BENSON, NORTH CAROLINA TO SUPPORT THE IMPLEMENTATION OF ITS SEWER TREATMENT CAPACITY PROJECT AS DIRECTED IN THE 2022 CONSOLIDATED APPROPRIATIONS ACT OR AS IDENTIFIED IN AN APPROVED TECHNICAL CORRECTION IF ONE HAS BEEN APPROVED FOR THIS PROJECT.ACTIVITIES:ACTIVITIES TO BE PERFORMED INCLUDE THE CONSTRUCTION OF THE TOWN'S SEPTAGE RECEIVING STATION.SUBRECIPIENT:NO SUBAWARDS ARE INCLUDED IN THIS ASSISTANCE AGREEMENT.OUTCOMES:THE ANTICIPATED DELIVERABLES INCLUDE THE CONSTRUCTION OF A SEPTAGE RECEIVING STATION AT THE TOWN OF BENSON'S 1.9 MGD WASTEWATER TREATMENT PLANT WITH A LOADING VOLUME OF 3,000 GALLONS/LOAD. THE EXPECTED OUTCOMES WILL INCLUDE A LOCAL SEPTAGE RECEIVING STATION TO REDUCE FOSSIL-FUEL EMISSIONS. THE INTENDED BENEFICIARIES INCLUDE THE RESIDENTS OF THE TOWN OF BENSON, NORTH CAROLINA.

LOW-COST PERSONAL SAMPLING PUMP

**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** GOLDFINCH SENSOR TECHNOLOGIES AND ANALYTICS LLC (GSTA) HAS A TECHNOLOGY SOLUTION FOR AUTOMATED, REAL-TIME ANALYSIS OF CONTAMINANT (E.G. METAL AND BONE) DETECTION APPLICABLE TO MEAT AND POULTRY SMART PROCESSING AND QUALITY CONTROL. GSTA'S TECHNOLOGY IS DESIGNED TO BE HAZARD ANALYSIS AND CRITICAL CONTROL POINTS (HACCP) COMPLIANT. IT INCLUDES ALERT MESSAGES, CALIBRATION STANDARDS, AND AUDIT TRAIL GENERATION. GSTA'S TECHNOLOGY USES A RADIO FREQUENCY (RF) DIGITAL NOSE TO DETECT CONTAMINANTS IN GROUND MEAT OR POULTRY PRODUCTS BY SPECTRAL ANALYSIS.

WASTE DISPOSAL GRANTS - REGULAR

DEVELOPMENT OF A NEW APPROACH TO SCREENING FOR LANGUAGE IMPAIRMENTS

OPTIMIZING A MINIATURIZED AND INTEGRATED CONTINUOUS GLUCOSE MONITORING PLATFORM - PROJECT SUMMARY THE LONG-TERM GOAL OF THIS PROJECT IS TO DEVELOP A SCALABLE, USER-FRIENDLY, CONTINUOUS GLUCOSE MONITORING (CGM) SYSTEM FOR BETTER DIABETES MANAGEMENT. IMS HAS DEVELOPED THE WORLD'S SMALLEST ELECTROCHEMICAL ANALYTE SENSING PLATFORM BASED ON AN APPLICATION-SPECIFIC INTEGRATED CIRCUIT (ASIC) USING COMPLEMENTARY METAL-OXIDE SEMICONDUCTOR (CMOS) TECHNOLOGY. THIS DESIGN OFFERS SOME UNIQUE ADVANTAGES DUE TO ITS ACTIVE DIGITAL SENSOR (COMPARED TO PASSIVE ANALOG SENSORS IN CURRENT LEADING CGMS) INCLUDING EXTREME MINIATURIZATION, ON-CHIP INTEGRATION OF MULTIPLE SENSORS AND PROCESSING ELECTRONICS, IMPROVEMENT IN SIGNAL-TO-NOISE (SNR) RATIO (THUS IMPROVING HYPOGLYCEMIA ACCURACY), AND ON-CHIP TEMPERATURE CALIBRATION (IMPROVE ACCURACY, RELIABILITY BY CONFIRMING THE SENSOR IS IN THE TISSUE, AND PERFORMING ON-SITE TEMPERATURE CALIBRATION DURING SICKNESS, EXERCISE, AND SLEEP). MOREOVER, THE SYSTEM USES EXTREMELY SCALABLE SEMICONDUCTOR AND FLEXIBLE ELECTRONICS MANUFACTURING METHODS, INCREASING LOT SIZES BY > 50,000X (SIMPLIFYING FACTORY CALIBRATION) AND REDUCING COST (IMPROVING AFFORDABILITY AND BROADENING USAGE). THE PROPOSED SYSTEM IS NAMED CGM+ SINCE IT GOES BEYOND JUST GLUCOSE MONITORING (V1 MEASURES GLUCOSE AND TEMPERATURE, V2 WILL MEASURE GLUCOSE, KETONES, TEMPERATURE, AND PH). HENCE, THE DESIGN IS HIGHLY INNOVATIVE. WE HAVE DEMONSTRATED THE FUNCTION OF THE CGM+ PLATFORM IN HUMANS IN A FIRST-IN-HUMAN (FIH) FEASIBILITY STUDY IN PHASE II. RECENTLY, WE VERIFIED THE FEASIBILITY OF SYSTEM OPERATION FOR 14 DAYS IN A SECOND HUMAN STUDY (ONGOING). OUR OBJECTIVE IN THIS CRP GRANT IS TO OPTIMIZE THE MANUFACTURING AND THE QUALITY FRAMEWORK TO ENABLE LARGER HUMAN STUDIES, PAVING THE WAY TOWARDS ENABLING AN FDA IDE FOR APPROVAL TRIALS. THIS WORK IS SIGNIFICANT AS IT WILL CATALYZE THE COMMERCIALIZATION OF THE FIRST CGM+ SYSTEM CAPABLE OF THE SMALLEST NEEDLE INSERTION (28-GAUGE NEEDLE) THAT CAN WORK FOR A LONG TIME (>14 DAYS) WITH FACTORY CALIBRATION (NO FINGER STICKS). AFTER THE FIRST APPROVAL, THIS SYSTEM CAN BE EXTENDED TO INCLUDE OTHER ANALYTES (E.G., KETONES, INSULIN, GLUCAGON) WITHOUT INCREASING ITS SIZE, OWING TO THE ON-CHIP INTEGRATION OF MULTIPLE SENSORS. THE TEAM INCLUDES ORIGINAL INVENTORS OF THE CORE TECHNOLOGY FROM THE CALIFORNIA INSTITUTE OF TECHNOLOGY (DR. NAZARI, DR. RAHMAN, MR. SENCAN), A SEASONED AND RESPECTED RESEARCHER IN ELECTROCHEMICAL SENSOR TECHNOLOGY (BILL VAN ANTWERP, FORMER CSO OF MEDTRONIC MINIMED), REGULATORY AND IP EXPERT (JOHN HEITHAUS, JD), COMMERCIALIZATION EXPERT (MR. PAUL STRASMA, FORMER CEO OF CAPILLARY BIOMEDICAL WHICH WAS RECENTLY ACQUIRED BY TANDEM DIABETES), CLINICAL EXPERT (DR. ALAN MARCUS, MD; FORMER CHIEF MEDICAL OFFICER OF MEDTRONIC DIABETES), AND A BIOSENSORS AND BIOMATERIALS EXPERT (DR. NATALIE WISNIEWSKI, PH.D., FORMER CTO OF PROFUSA, INC.).

SIMULTANEOUS ASSAY FOR MULTIPLE PATHOGENS IN BLOOD (SAMP-B)

81-1011-19 CYBER SECURE OPEN SOURCE INFO AND ANALYSIS

BENSON CANAL ENCLOSURE

STTR PHASE II: NOVEL REAL-TIME PARTICULATE MATTER (PM) SENSOR FOR AIR QUALITY MEASUREMENTS

MEAT AND POULTRY PROCESSING EXPANSION PROGRAM GRANTS - ARP

SBIR PHASE II: RAPID ASSESSMENT OF ANTIBIOTIC RESISTANCE BY MASS MEASUREMENT

A NOVEL FLUORESCENT ASSAY FOR UBIQUITIN ISOPEPTIDE BOND CLEAVAGE

SBIR PHASE II: RESOURCE-EFFICIENT REMOTE MONITORING AND DIAGNOSTICS FOR CYBER-PHYSICAL SYSTEMS

SBIR PHASE II: NUTRIENT-ENHANCED SOYBEAN FOR AQUAFEED

HIGH PRECISION ELECTRON GUN DEVELOPMENT FOR GYROTRONS

SBIR PHASE II: DEVELOPMENT OF RESONANT WAVEGUIDE-GRATING ELEMENTS FOR HIGH THROUGHPUT SCREENING OF PROTEINS

PUBLIC AND INDIAN HOUSING

DOMESTIC WATER GRANTS - REGULAR

NOVEL, LOW COST, HIGH GAIN, MICROPATTERN DETECTOR

REMOTE SENSING THROUGH IMAGING POLARIMETRY FOR NUCLEAR NON-PROLIFERATION

PUBLIC AND INDIAN HOUSING

INCREASED SEED OIL BY METABOLIC REGULATION

SBIR PHASE II: GABA-MEDIATED NITROGEN EFFICIENCY

NURSING WORKFORCE DIVERSITY

PUBLIC AND INDIAN HOUSING

SBIR PHASE II: DEVELOPING A REAL-TIME HIGH-DATA-RATE MULTICARRIER UNDERWATER ACOUSTIC MODEM

SINGLE CELL RNA AMPLIFICATION NANODROP PROCESSOR

PUBLIC AND INDIAN HOUSING

ASSISTANCE TO FIREFIGHTERS GRANT

PUBLIC AND INDIAN HOUSING

A PARALLEL HIGH-THROUGHPUT PHARMACOGENETIC PROFILING ASSAY FOR CLINICAL USE

FUND FOR THE IMPROVEMENT OF EDUCATION - CAROL M. WHITE PHYSCIAL EDUCATION PROGRAM

SEE SCHEDULE

SBIR PHASE II: PARTICLE METROLOGY AND DIAGNOSTICS USING MICROCHANNEL RESONATORS

INCREASED SEED OIL BY METABOLIC REGULATION

PURPOSE: THE PUBLIC HOUSING OPERATING FUND (PH OPFUND) PROVIDES OPERATING SUBSIDIES TO HOUSING AUTHORITIES (HAS) TO ASSIST IN FUNDING THE OPERATING AND MAINTENANCE EXPENSES OF THEIR DWELLINGS, IN ACCORDANCE WITH SECTION 9 OF THE U.S. HOUSING ACT OF 1937, AS AMENDED. THE SUBSIDIES ARE REQUIRED TO HELP MAINTAIN SERVICES AND PROVIDE MINIMUM OPERATING RESERVES. THE PH OPFUND IS A $5 BILLION DOLLAR PROGRAM PROVIDING FUNDING TO APPROXIMATELY 6,000 HAS SERVING 1,590,321 PUBLIC HOUSING RESIDENTS IN 902,436 HOUSEHOLDS (44% ARE ELDERLY AND 35% OF RESIDENTS HAVE CHILDREN). INFORMATION ON THE CURRENT OPERATING FUND GRANT PROCESSING CAN BE FOUND AT HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/PUBLIC_INDIAN_HOUSING/PROGRAMS/PH/AM/FUNDING.; ACTIVITIES TO BE PERFORMED: OPERATING FUNDS ARE USED TO FUND DAY-TO-DAY OPERATIONAL EXPENSES ASSOCIATED WITH PUBLIC HOUSING AS WELL AS THE ADMINISTRATIVE AND PROGRAM IMPLEMENTATION EXPENSES THAT PUBLIC HOUSING AGENCIES (PHAS) ARE REQUIRED TO UNDERTAKE UNDER THE 1937 HOUSING ACT AND PROGRAM REGULATIONS. SUCH ACTIVITIES INCLUDE MANAGEMENT AND OPERATIONS, ROUTINE AND PREVENTATIVE MAINTENANCE, ANTI-CRIME, ANTI-DRUG AND SECURITY ACTIVITIES, OPERATING COSTS FOR PRIVATELY OWNED PUBLIC HOUSING UNITS WITHIN MIXED-FINANCE PROJECTS, ENERGY COSTS, RESIDENT SUPPORTIVE SERVICES, INSURANCE, DEBT SERVICE AND COSTS ASSOCIATED WITH ADMINISTRATION AND PROGRAM IMPLEMENTATION. TURNKEY III PROJECTS ARE FUNDED FOR UNITS UNDER THE FINAL LEASE PURCHASE AGREEMENT FOR CLOSING OUT THE PROGRAM. TO SUPPORT THESE ACTIVITIES, THERE IS CONTINUED MODERNIZATION OF THE INFORMATION TECHNOLOGY PLATFORMS. PHAS HAVE ACCESS TO WEB-BASED PLATFORMS THAT UTILIZE REAL-TIME DATA TO PROVIDE INSIGHT INTO THEIR PORTFOLIOS. PHAS CAN OBTAIN METRICS ON THEIR FUNDING LEVELS, OCCUPANCY RATES, AND THE NUMBER OF FAMILIES SERVED THROUGH RENTAL ASSISTANCE.; EXPECTED OUTCOMES: AS A RESULT OF THE ACTIVITIES PERFORMED, THIS PROGRAM IS EXPECTED TO ASSIST IN FUNDING THE OPERATING AND MAINTENANCE EXPENSES. THIS MAY INCLUDE INCREASED OCCUPANCY IN PUBLIC HOUSING, DECREASED ENERGY COSTS THROUGH REGULAR MAINTENANCE AND ENERGY PERFORMANCE CONTRACTING AND LEVERAGE FEDERAL RESOURCES. IN ADDITION TO ADDRESSING THE DEPARTMENT’S STRATEGIC GOALS OF: • ADDRESSING THE NEED FOR QUALITY AFFORDABLE RENTAL HOMES BY MAINTAINING OR IMPROVING UPON THE 96% OCCUPANCY RATE OF HABITABLE UNITS; • PROMOTING HOUSING AS A PLATFORM TO IMPROVE QUALITY OF LIFE THROUGH SUPPORTIVE SERVICES, CRIME PREVENTION EFFORTS AND RESIDENT ENGAGEMENT ACTIVITIES; AND • HELPING TO BUILD INCLUSIVE COMMUNITIES FREE FROM DISCRIMINATION BY FACILITATING THE IMPLEMENTATION OF AFFIRMATIVELY FURTHERING FAIR HOUSING MEASURES.; INTENDED BENEFICIARIES: THE OPERATING FUND PROVIDES FOR THE OPERATION AND MAINTENANCE OF LOW-INCOME HOUSING PROJECTS TO PHAS/PROJECTS. IT WAS CREATED TO ASSIST HOUSING AUTHORITIES IN PROVIDING DECENT AND SAFE RENTAL HOUSING FOR ELIGIBLE LOW-INCOME FAMILIES OR INDIVIDUALS, THE ELDERLY, AND PERSONS WITH DISABILITIES. A HA DETERMINES ELIGIBILITY BASED ON 1) ANNUAL GROSS INCOME; 2) A PERSON ON WHO IS ELDERLY, A PERSON WITH A DISABILITY, OR AS A FAMILY; AND 3) U.S. CITIZENSHIP OR ELIGIBLE IMMIGRATION STATUS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

PUBLIC AND INDIAN HOUSING

SBIR PHASE II: HIGH RESOLUTION TUNABLE RECEIVER FOR REMOTE THZ SENSING

PUBLIC AND INDIAN HOUSING

HIGH FREQUENCY RADAR (HFR) PROVIDES ONE OF THE 30 ESSENTIAL OCEAN VARIABLES OUTLINED IN THE U.S. INTEGRATED OCEAN OBSERVING SYSTEM (IOOS) MISSION, AND IS THE ONLY INSTRUMENT SYSTEM OPERATIONALLY PROVIDING BOTH HIGH TEMPORAL AND SPATIAL RESOLUTION OBSERVATIONS OVER THE CONTINENTAL SHELF. APPROXIMATELY 85% OF THE IOOS HFRS ARE CODAR SEASONDES, WITH MEASUREMENTS CONSISTING OF RANGE, BEARING, AND VELOCITY OF A SEA SURFACE PATCH. THE SEASONDES UTILIZE ALGORITHMS ALONG WITH A COMPACT ANTENNA SYSTEM TO DETERMINE THE BEARING. RANGE AND VELOCITY ARE HIGHLY ACCURATE, WHILE THE BEARING DETERMINATION IS THE GREATEST SOURCE OF ERROR. A FURTHER ISSUE IS THAT THESE MEASUREMENTS PRESENTLY PROVIDE NO INDICATION OF MEASUREMENT UNCERTAINTY, WHICH HAS HINDERED UTILIZATION OF HFR OBSERVATIONS BY MODELERS AND FORECASTERS, AND PRESENTS A CHALLENGE FOR HFR OPERATORS PERFORMING DATA QUALITY CONTROL. TO RESOLVE THESE ISSUES, WE HAVE DEVELOPED AN ARTIFICIAL INTELLIGENCE (AI) APPROACH TO THE BEARING DE

COMMUNITY INFRASTRUCTURE

PERFORM FUNDING SYS

PUBLIC HOUSING CAPITAL FUND

ASSISTANCE TO FIREFIGHTERS GRANTS

PERFORM FUNDING SYS

IMPROVE EXISTING AIRPORT C

LEADERSHIP

SWEDAR AN AUTOMATED LOW-POWER SNOW WATER EQUIVALENT SENSOR

SBIR PHASE II: HIGH POWER DEEP UV LED-BASED LAMPS

THIS PHASE II WORK IS BROKEN DOWN INTO THREE MAIN CATEGORIES: HARDWARE AND INTEGRATION (~30%), DATA COLLECTION (~25%), AND ALGORITHM DEVELOPMENT AND DATA ANALYSIS (~45%). MUCH OF THIS WORK WILL BE HAPPENING IN PARALLEL AS EXISTING SYSTEMS ARE UPDATED AND USES AS NEXT STAGE SYSTEMS ARE UNDER DEVELOPMENT. NWB SENSORS, INC. IMPLEMENTS AN ITERATIVE SCIENTIFIC / ENGINEERING APPROACH ON ALL OUR PROJECTS. THIS APPROACH FOLLOWS THE STEPS OF 1. MODEL THE PROBLEM OR DESIGN THE SYSTEM, 2. VALIDATE THE MODEL OR SYSTEM DATA BY COLLECTING REAL WORLD DATA (TESTING), 3. REFINE THE MODEL OR SYSTEM IF DESIRED PERFORMANCE WAS NOT ACHIEVED. THROUGHOUT THE PROJECT ENGINEERING PROJECT MANAGEMENT METHODS WILL BE IMPLEMENTED. THESE METHODS INCLUDE INDUSTRY STANDARD SOFTWARE TOOLS FOR: COLLABORATIVE PROJECT MANAGEMENT; DOCUMENTATION; SOFTWARE VERSION CONTROL, AND BACKUP OF PROJECT DOCUMENTS.DEVELOPMENT ON THE IMPROVED CAMERA CONTROLLER WILL START IN FALL 2019 AND CONTINUE INTO EARLY SPRING 2020. AT THIS TIMETHE CAMERA CONTROLLER WILL BE UPDATED TO IMPLEMENT IMPROVED MOVEMENT DETECTION AND CAMERA CONTROL. DURING DEVELOPMENT THESE MOTION DETECTION AND CAMERA CONTROL ROUTINES WILL BE TESTED USING AUTOMOBILES IN SIMULATED FIELD TESTS. WORK DURING THE EARLY SPRING WILL VALIDATE THESE IMPROVEMENTS IN FARM TESTS. INITIAL WORK ON THE NVIDIA JETSON EMBEDDED MACHINE VISION PLATFORM WILL ALSO START AT THIS TIME WITH THE GOAL OF PROTOTYPE FIELD TEST DURING THE ON-FARM EXPERIMENTS IN SUMMER 2020. BASED ON THE RESULTS OF THESE TESTS THE PROTOTYPE SYSTEM WILL BE IMPROVED UPON DURING FALL AND WINTER 2020 TO BE READY FOR FIELD TESTS IN SUMMER 2021.DEVELOPMENT TO IMPROVE THE DATA PROCESSING TOOLCHAIN AND TO IMPLEMENT THE END USER DATA APPLICATION WILL HAPPEN IN PARALLEL AND WILL TAKE PLACE THROUGHOUT THE PROJECT STARTING IN FALL 2019. THE FIRST TASK OF THIS EFFORT WILL BE TO IMPLEMENT OBJECT TRACKING IN THE DATA PROCESSING TOOL CHAIN. THE ILLUMINATION CORRECTION AND IMPROVED ANOMALY DETECTION WILL UTILIZETHE OBJECT TRACKING ROUTINES. AS NEW IMAGERY IS ADDED DURING THE 2020 AND 2021 SUMMER THESE ROUTINES WILL BE IMPROVED AS NECESSARY. TESTING OF THE METHODS TO COMMUNICATE IN FIELD DATA WILL BE DEVELOPED WITH A PROTOTYPE READY FOR SUMMER 2020.CRITICAL TO THE SUCCESS OF THIS PROJECT IS THE CREATION OF TOOLS TO ALLOW FOR SYSTEM OF LEARNING FOR NEW ENVIRONMENTS. DEVELOPMENT ON THE METHODS FOR ASSISTED TRAINING USING AUTO-SORTED CLASSES CAN START IN FALL 2019. THIS WORK CAN USE OBJECT IDENTIFICATION GRAPHS TRAINED ON GRAIN CROPS BUT BEING ADAPTED TO PULSE CROPS. VALIDATION OF THESE TECHNIQUES WILL USE COMPARISONS WITH EXISTING HUMAN BUILT GRAPHS FOR PULSE CROP OBJECT IDENTIFICATION. AFTER THE MOTION TRACKING HAS BEEN INTEGRATED INTO THE TOOL CHAIN FURTHER DEVELOPMENT ON AUTOMATED NEW CROP AND OBJECT DETECTION CAN TAKE PLACE.WORK TO VALIDATE DATA PROCESSING AND TRAINING TOOL CHAINS WILL TAKE PLACE THROUGHOUT THE PROJECT USING BOTH NEWLY COLLECTED AND EXISTING DATA. VALIDATION WILL REQUIRE CLOSE WORK WITH OUR CO-OPERATING GROWERS AND LANDOWNERS TO ENSURE THE MAPPING DATA IS ACCURATE AND IN FORMATS USABLE IN THEIR OPERATIONS.

COMPACT THERMOELASTIC COOLING SYSTEM

AC LOAD LOCALIZATION, CHARACTERIZATION, AND ADVANCED SIGNAL PROCESSING

NITRIC OXIDE MICROFLUIDIC SENSOR

A NEW NANO-BASED DETECTOR FOR THE INDIAN MEAL MOTH, BOTH ADULT INSECTS AND LARVA

CREATING AN ADVANCED, ECONOMICAL, ECO-FRIENDLY MEASUREMENT OF SNOW WATER EQUIVALENCE USING OBSERVED GNSS SIGNALS BENEATH THE SNOW

A LOW-COST PATHOGEN DETECTION SYSTEM IS PROPOSED COMPRISING AN INCUBATOR-READER UNIT AS WELL AS A LOW-COST CONSUMABLE PAPER-BASED INDICATOR TEST STR

DOMESTIC WATER GRANTS - 09/10 MULTI-YEAR STIMULUS

RURAL HEALTH CARE SERVICES OUTREACH GRANT PROGRAM

DEVELOPMENT OF A MULTI-SAMPLE TESTING PLATFORM FOR A RAPID, FACILE IDENTIFICATION OF RALSTONIA SOLANACEARUM

ESTABLISHING AN OFFICE OF RESEARCH DEVELOPMENT AT VILLA*

PURPOSE: THE PUBLIC HOUSING CAPITAL FUND PROGRAM (CFP) WAS CREATED BY AN AMENDMENT TO THE 1937 ACT BY THE QUALITY HOUSING AND WORK RESPONSIBILITY ACT (QHWRA) IN 1998 (ADDING SECTION 9(D) TO THE 1937 ACT MERGING PREVIOUS MODERNIZATION AND DEVELOPMENT PROGRAMS). THE CFP PROVIDES FINANCIAL ASSISTANCE IN THE FORM OF GRANTS TO APPROXIMATELY 2,770 PUBLIC HOUSING AGENCIES (PHAS), SERVING NEARLY ONE MILLION UNITS, IN ALL 50 STATES AND TERRITORIES, TO CARRY OUT CAPITAL AND MANAGEMENT ACTIVITIES INCLUDING THOSE LISTED IN SECTION 9(D)(1) OF THE UNITED STATES HOUSING ACT OF 1937 (1937 ACT). THE MAIN PURPOSE OF THE CFP FORMULA GRANT IS TO FUND PUBLIC HOUSING MODERNIZATION, DEVELOPMENT, MANAGEMENT IMPROVEMENTS, AND THE OTHER ELIGIBLE ACTIVITIES DESCRIBED IN 24 CFR PART 905. ADDITIONAL INFORMATION ON THE PUBLIC HOUSING CAPITAL FUND IS LOCATED ON THE OFFICE OF CAPITAL IMPROVEMENTS WEBSITE: OFFICE OF CAPITAL IMPROVEMENTS | HUD.GOV / U.S. DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT (HUD) ADDITIONAL INFORMATION ON PUBLIC HOUSING FUNDING CAN BE FOUND BY ACCESSING THE WEBSITE BELOW AND REVIEWING THE PUBLIC HOUSING DASHBOARD LINKED UNDER THE “DATA DASHBOARD AND ANALYTICS”. PUBLIC HOUSING | HUD.GOV / U.S. DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT (HUD); ACTIVITIES TO BE PERFORMED: THE PHAS RECEIVE FEDERAL FUNDS FROM THE U.S. DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT (HUD) TO ADMINISTER THE PUBLIC HOUSING FUND. PUBLIC HOUSING CAPITAL FUNDS MAY ONLY BE USED FOR ACTIVITIES THAT ARE DESCRIBED AS ELIGIBLE ACTIVITIES IN 24 CFR 905.200 AND ARE EITHER SPECIFIED IN AN APPROVED 5-YEAR ACTION PLAN OR APPROVED BY HUD FOR EMERGENCY WORK OR WORK NEEDED BECAUSE OF A NON-PRESIDENTIALLY DECLARED NATURAL DISASTER. PUBLIC HOUSING DEVELOPMENT, MODERNIZATION, AND FINANCING ARE THE MAJOR ACTIVITIES TO BE PERFORMED. DEVELOPMENT IS ACTIVITIES AND RELATED COSTS THAT ADD TO (OR SIGNIFICANTLY RECONFIGURE) PUBLIC HOUSING UNITS IN A PHA’S INVENTORY, INCLUDING CONSTRUCTION AND ACQUISITION OF ADDITIONAL PUBLIC HOUSING UNITS, WITH OR WITHOUT REHABILITATION, AND ANY-AND-ALL UNDERTAKINGS NECESSARY FOR PLANNING, DESIGN, FINANCING, LAND ACQUISITION, DEMOLITION, CONSTRUCTION, OR EQUIPMENT OF PUBLIC HOUSING UNITS, AND RELATED BUILDINGS, FACILITIES, AND/OR APPURTENANCES (I.E., NON-DWELLING FACILITIES/SPACES). DEVELOPMENT ALSO INCLUDES ANY MIXED-FINANCE MODERNIZATION, ALL RELEVANT MODERNIZATION USES (OTHER THAN MANAGEMENT IMPROVEMENTS), FINANCING USES, AND DEVELOPMENT OF NON-DWELLING SPACE WHERE SUCH SPACE IS NEEDED TO ADMINISTER, AND IS OF DIRECT BENEFIT TO A PUBLIC HOUSING PROJECT (I.E. HOUSING DEVELOPED, ACQUIRED, OR ASSISTED BY A PHA UNDER THE 1937 ACT, AND THE IMPROVEMENT OF ANY SUCH HOUSING), INCLUDING THE RESIDENTS. FINANCING DEBT AND FINANCING COSTS (E.G., ORIGINATION FEES, INTEREST) INCURRED BY A PHA FOR DEVELOPMENT OR MODERNIZATION OF PUBLIC HOUSING PROJECTS, INCLUDING MIXED-FINANCE DEVELOPMENT, THE CAPITAL FUND FINANCING PROGRAM (CFFP), AND ANY OTHER USE AUTHORIZED UNDER SECTION 30 OF THE 1937 ACT. MODERNIZATION INCLUDES ALL ELIGIBLE ACTIVITIES EXCEPT FOR DEVELOPMENT AND FINANCING. PHYSICAL WORK IS A MAJOR ACTIVITY AND IS WORK THAT IS DONE ON THE PHYSICAL STRUCTURES, SITE, AND GROUNDS OF A PUBLIC HOUSING PROPERTY OR STRUCTURE. MAJOR PHYSICAL ACTIVITIES INCLUDE DEMOLITION, RECONFIGURATION, EMERGENCY ACTIVITIES, ENERGY EFFICIENCY, NON-ROUTINE MAINTENANCE, PLANNED CODE COMPLIANCE, AND VACANCY REDUCTION. THE MEASURABLE OUTCOME OF THIS GRANT IS THAT HUD WILL BE ABLE TO TRACK THE AMOUNT OF DOLLARS SPENT ON IMPROVEMENTS TO THE STRUCTURES, UNITS, COMMON AREAS, UTILITIES, AND OTHER ELIGIBLE ACTIVITIES. ; EXPECTED OUTCOMES: THE EXPECTED OUTCOMES FOR PUBLIC HOUSING CAPITAL FUNDS OF APPROXIMATELY $3.2 BILLION WILL BE PUT INTO THE DEVELOPMENT, MODERNIZATION, AND FINANCING OF NEARLY 1 MILLION PUBLIC HOUSING UNITS ACROSS ALL 50 STATES AND TERRITORIES. THE PUBLIC HOUSING UNITS ARE UPDATED TO BE DECENT, SAFE, SANITARY AND TO COMPLY WITH FEDERAL HOUSING STANDARDS. PHAS CAN ALSO USE A PORTION OF THE CAPITAL FUNDING FOR MANAGEMENT IMPROVEMENTS OR OPERATING ACTIVITIES INCLUDING SAFETY AND SECURITY COSTS.; INTENDED BENEFICIARIES: THE INTENDED BENEFICIARIES FOR PUBLIC HOUSING CAPITAL FUNDS ARE THE LOW-INCOME PUBLIC HOUSING RESIDENTS.; SUBRECIPIENT ACTIVITIES: THE RECIPIENT DOES NOT INTEND TO SUBAWARD FUNDS.

IMPROVE EXISTING AIRPORT

IMPROVE EXISTING AIRPORT

PUBLIC HOUSING CAPITAL FUND

PURPOSE: THE PUBLIC HOUSING CAPITAL FUND PROGRAM (CFP) WAS CREATED BY AN AMENDMENT TO THE 1937 ACT BY THE QUALITY HOUSING AND WORK RESPONSIBILITY ACT (QHWRA) IN 1998 (ADDING SECTION 9(D) TO THE 1937 ACT MERGING PREVIOUS MODERNIZATION AND DEVELOPMENT PROGRAMS). THE CFP PROVIDES FINANCIAL ASSISTANCE IN THE FORM OF GRANTS TO APPROXIMATELY 2,770 PUBLIC HOUSING AGENCIES (PHAS), SERVING NEARLY ONE MILLION UNITS, IN ALL 50 STATES AND TERRITORIES, TO CARRY OUT CAPITAL AND MANAGEMENT ACTIVITIES INCLUDING THOSE LISTED IN SECTION 9(D)(1) OF THE UNITED STATES HOUSING ACT OF 1937 (1937 ACT). THE MAIN PURPOSE OF THE CFP FORMULA GRANT IS TO FUND PUBLIC HOUSING MODERNIZATION, DEVELOPMENT, MANAGEMENT IMPROVEMENTS, AND THE OTHER ELIGIBLE ACTIVITIES DESCRIBED IN 24 CFR PART 905. ADDITIONAL INFORMATION ON THE PUBLIC HOUSING CAPITAL FUND IS LOCATED ON THE OFFICE OF CAPITAL IMPROVEMENTS WEBSITE: OFFICE OF CAPITAL IMPROVEMENTS | HUD.GOV / U.S. DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT (HUD) ADDITIONAL INFORMATION ON PUBLIC HOUSING FUNDING CAN BE FOUND BY ACCESSING THE WEBSITE BELOW AND REVIEWING THE PUBLIC HOUSING DASHBOARD LINKED UNDER THE “DATA DASHBOARD AND ANALYTICS”. PUBLIC HOUSING | HUD.GOV / U.S. DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT (HUD); ACTIVITIES TO BE PERFORMED: THE PHAS RECEIVE FEDERAL FUNDS FROM THE U.S. DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT (HUD) TO ADMINISTER THE PUBLIC HOUSING FUND. PUBLIC HOUSING CAPITAL FUNDS MAY ONLY BE USED FOR ACTIVITIES THAT ARE DESCRIBED AS ELIGIBLE ACTIVITIES IN 24 CFR 905.200 AND ARE EITHER SPECIFIED IN AN APPROVED 5-YEAR ACTION PLAN OR APPROVED BY HUD FOR EMERGENCY WORK OR WORK NEEDED BECAUSE OF A NON-PRESIDENTIALLY DECLARED NATURAL DISASTER. PUBLIC HOUSING DEVELOPMENT, MODERNIZATION, AND FINANCING ARE THE MAJOR ACTIVITIES TO BE PERFORMED. DEVELOPMENT IS ACTIVITIES AND RELATED COSTS THAT ADD TO (OR SIGNIFICANTLY RECONFIGURE) PUBLIC HOUSING UNITS IN A PHA’S INVENTORY, INCLUDING CONSTRUCTION AND ACQUISITION OF ADDITIONAL PUBLIC HOUSING UNITS, WITH OR WITHOUT REHABILITATION, AND ANY-AND-ALL UNDERTAKINGS NECESSARY FOR PLANNING, DESIGN, FINANCING, LAND ACQUISITION, DEMOLITION, CONSTRUCTION, OR EQUIPMENT OF PUBLIC HOUSING UNITS, AND RELATED BUILDINGS, FACILITIES, AND/OR APPURTENANCES (I.E., NON-DWELLING FACILITIES/SPACES). DEVELOPMENT ALSO INCLUDES ANY MIXED-FINANCE MODERNIZATION, ALL RELEVANT MODERNIZATION USES (OTHER THAN MANAGEMENT IMPROVEMENTS), FINANCING USES, AND DEVELOPMENT OF NON-DWELLING SPACE WHERE SUCH SPACE IS NEEDED TO ADMINISTER, AND IS OF DIRECT BENEFIT TO A PUBLIC HOUSING PROJECT (I.E. HOUSING DEVELOPED, ACQUIRED, OR ASSISTED BY A PHA UNDER THE 1937 ACT, AND THE IMPROVEMENT OF ANY SUCH HOUSING), INCLUDING THE RESIDENTS. FINANCING DEBT AND FINANCING COSTS (E.G., ORIGINATION FEES, INTEREST) INCURRED BY A PHA FOR DEVELOPMENT OR MODERNIZATION OF PUBLIC HOUSING PROJECTS, INCLUDING MIXED-FINANCE DEVELOPMENT, THE CAPITAL FUND FINANCING PROGRAM (CFFP), AND ANY OTHER USE AUTHORIZED UNDER SECTION 30 OF THE 1937 ACT. MODERNIZATION INCLUDES ALL ELIGIBLE ACTIVITIES EXCEPT FOR DEVELOPMENT AND FINANCING. PHYSICAL WORK IS A MAJOR ACTIVITY AND IS WORK THAT IS DONE ON THE PHYSICAL STRUCTURES, SITE, AND GROUNDS OF A PUBLIC HOUSING PROPERTY OR STRUCTURE. MAJOR PHYSICAL ACTIVITIES INCLUDE DEMOLITION, RECONFIGURATION, EMERGENCY ACTIVITIES, ENERGY EFFICIENCY, NON-ROUTINE MAINTENANCE, PLANNED CODE COMPLIANCE, AND VACANCY REDUCTION. THE MEASURABLE OUTCOME OF THIS GRANT IS THAT HUD WILL BE ABLE TO TRACK THE AMOUNT OF DOLLARS SPENT ON IMPROVEMENTS TO THE STRUCTURES, UNITS, COMMON AREAS, UTILITIES, AND OTHER ELIGIBLE ACTIVITIES. ; EXPECTED OUTCOMES: THE EXPECTED OUTCOMES FOR PUBLIC HOUSING CAPITAL FUNDS OF APPROXIMATELY $3.2 BILLION WILL BE PUT INTO THE DEVELOPMENT, MODERNIZATION, AND FINANCING OF NEARLY 1 MILLION PUBLIC HOUSING UNITS ACROSS ALL 50 STATES AND TERRITORIES. THE PUBLIC HOUSING UNITS ARE UPDATED TO BE DECENT, SAFE, SANITARY AND TO COMPLY WITH FEDERAL HOUSING STANDARDS. PHAS CAN ALSO USE A PORTION OF THE CAPITAL FUNDING FOR MANAGEMENT IMPROVEMENTS OR OPERATING ACTIVITIES INCLUDING SAFETY AND SECURITY COSTS.; INTENDED BENEFICIARIES: THE INTENDED BENEFICIARIES FOR PUBLIC HOUSING CAPITAL FUNDS ARE THE LOW-INCOME PUBLIC HOUSING RESIDENTS.; SUBRECIPIENT ACTIVITIES: THE RECIPIENT DOES NOT INTEND TO SUBAWARD FUNDS.

PUBLIC HOUSING CAPITAL FUND

PURPOSE: THE PUBLIC HOUSING CAPITAL FUND PROGRAM (CFP) WAS CREATED BY AN AMENDMENT TO THE 1937 ACT BY THE QUALITY HOUSING AND WORK RESPONSIBILITY ACT (QHWRA) IN 1998 (ADDING SECTION 9(D) TO THE 1937 ACT MERGING PREVIOUS MODERNIZATION AND DEVELOPMENT PROGRAMS). THE CFP PROVIDES FINANCIAL ASSISTANCE IN THE FORM OF GRANTS TO APPROXIMATELY 2,770 PUBLIC HOUSING AGENCIES (PHAS), SERVING NEARLY ONE MILLION UNITS, IN ALL 50 STATES AND TERRITORIES, TO CARRY OUT CAPITAL AND MANAGEMENT ACTIVITIES INCLUDING THOSE LISTED IN SECTION 9(D)(1) OF THE UNITED STATES HOUSING ACT OF 1937 (1937 ACT). THE MAIN PURPOSE OF THE CFP FORMULA GRANT IS TO FUND PUBLIC HOUSING MODERNIZATION, DEVELOPMENT, MANAGEMENT IMPROVEMENTS, AND THE OTHER ELIGIBLE ACTIVITIES DESCRIBED IN 24 CFR PART 905. ADDITIONAL INFORMATION ON THE PUBLIC HOUSING CAPITAL FUND IS LOCATED ON THE OFFICE OF CAPITAL IMPROVEMENTS WEBSITE: OFFICE OF CAPITAL IMPROVEMENTS | HUD.GOV / U.S. DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT (HUD) ADDITIONAL INFORMATION ON PUBLIC HOUSING FUNDING CAN BE FOUND BY ACCESSING THE WEBSITE BELOW AND REVIEWING THE PUBLIC HOUSING DASHBOARD LINKED UNDER THE “DATA DASHBOARD AND ANALYTICS”. PUBLIC HOUSING | HUD.GOV / U.S. DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT (HUD); ACTIVITIES TO BE PERFORMED: THE PHAS RECEIVE FEDERAL FUNDS FROM THE U.S. DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT (HUD) TO ADMINISTER THE PUBLIC HOUSING FUND. PUBLIC HOUSING CAPITAL FUNDS MAY ONLY BE USED FOR ACTIVITIES THAT ARE DESCRIBED AS ELIGIBLE ACTIVITIES IN 24 CFR 905.200 AND ARE EITHER SPECIFIED IN AN APPROVED 5-YEAR ACTION PLAN OR APPROVED BY HUD FOR EMERGENCY WORK OR WORK NEEDED BECAUSE OF A NON-PRESIDENTIALLY DECLARED NATURAL DISASTER. PUBLIC HOUSING DEVELOPMENT, MODERNIZATION, AND FINANCING ARE THE MAJOR ACTIVITIES TO BE PERFORMED. DEVELOPMENT IS ACTIVITIES AND RELATED COSTS THAT ADD TO (OR SIGNIFICANTLY RECONFIGURE) PUBLIC HOUSING UNITS IN A PHA’S INVENTORY, INCLUDING CONSTRUCTION AND ACQUISITION OF ADDITIONAL PUBLIC HOUSING UNITS, WITH OR WITHOUT REHABILITATION, AND ANY-AND-ALL UNDERTAKINGS NECESSARY FOR PLANNING, DESIGN, FINANCING, LAND ACQUISITION, DEMOLITION, CONSTRUCTION, OR EQUIPMENT OF PUBLIC HOUSING UNITS, AND RELATED BUILDINGS, FACILITIES, AND/OR APPURTENANCES (I.E., NON-DWELLING FACILITIES/SPACES). DEVELOPMENT ALSO INCLUDES ANY MIXED-FINANCE MODERNIZATION, ALL RELEVANT MODERNIZATION USES (OTHER THAN MANAGEMENT IMPROVEMENTS), FINANCING USES, AND DEVELOPMENT OF NON-DWELLING SPACE WHERE SUCH SPACE IS NEEDED TO ADMINISTER, AND IS OF DIRECT BENEFIT TO A PUBLIC HOUSING PROJECT (I.E. HOUSING DEVELOPED, ACQUIRED, OR ASSISTED BY A PHA UNDER THE 1937 ACT, AND THE IMPROVEMENT OF ANY SUCH HOUSING), INCLUDING THE RESIDENTS. FINANCING DEBT AND FINANCING COSTS (E.G., ORIGINATION FEES, INTEREST) INCURRED BY A PHA FOR DEVELOPMENT OR MODERNIZATION OF PUBLIC HOUSING PROJECTS, INCLUDING MIXED-FINANCE DEVELOPMENT, THE CAPITAL FUND FINANCING PROGRAM (CFFP), AND ANY OTHER USE AUTHORIZED UNDER SECTION 30 OF THE 1937 ACT. MODERNIZATION INCLUDES ALL ELIGIBLE ACTIVITIES EXCEPT FOR DEVELOPMENT AND FINANCING. PHYSICAL WORK IS A MAJOR ACTIVITY AND IS WORK THAT IS DONE ON THE PHYSICAL STRUCTURES, SITE, AND GROUNDS OF A PUBLIC HOUSING PROPERTY OR STRUCTURE. MAJOR PHYSICAL ACTIVITIES INCLUDE DEMOLITION, RECONFIGURATION, EMERGENCY ACTIVITIES, ENERGY EFFICIENCY, NON-ROUTINE MAINTENANCE, PLANNED CODE COMPLIANCE, AND VACANCY REDUCTION. THE MEASURABLE OUTCOME OF THIS GRANT IS THAT HUD WILL BE ABLE TO TRACK THE AMOUNT OF DOLLARS SPENT ON IMPROVEMENTS TO THE STRUCTURES, UNITS, COMMON AREAS, UTILITIES, AND OTHER ELIGIBLE ACTIVITIES. ; EXPECTED OUTCOMES: THE EXPECTED OUTCOMES FOR PUBLIC HOUSING CAPITAL FUNDS OF APPROXIMATELY $3.2 BILLION WILL BE PUT INTO THE DEVELOPMENT, MODERNIZATION, AND FINANCING OF NEARLY 1 MILLION PUBLIC HOUSING UNITS ACROSS ALL 50 STATES AND TERRITORIES. THE PUBLIC HOUSING UNITS ARE UPDATED TO BE DECENT, SAFE, SANITARY AND TO COMPLY WITH FEDERAL HOUSING STANDARDS. PHAS CAN ALSO USE A PORTION OF THE CAPITAL FUNDING FOR MANAGEMENT IMPROVEMENTS OR OPERATING ACTIVITIES INCLUDING SAFETY AND SECURITY COSTS.; INTENDED BENEFICIARIES: THE INTENDED BENEFICIARIES FOR PUBLIC HOUSING CAPITAL FUNDS ARE THE LOW-INCOME PUBLIC HOUSING RESIDENTS.; SUBRECIPIENT ACTIVITIES: THE RECIPIENT DOES NOT INTEND TO SUBAWARD FUNDS.

PERFORM FUNDING SYS

WATER SYSTEM (UPGRADE)

WATER SYSTEM (NEW)

WATER SYSTEM (NEW)

BUSINESS SITE DEVELOPMENT

SBIR PHASE II: REAL-TIME ECONOMIC SAMPLING SYSTEM

STTR PHASE II: ZERO-POWER RADIO FREQUENCY IDENTIFICATION (RFID) SENSING TAGS

THE PHYTER IS A HANDHELD DEVICE THAT ACCURATELY MEASURES PH USING COLORIMETRY, COMMUNICATING WITH A CELLPHONE VIA BLUETOOTH LOW ENERGY. THE APP RECORDS LOCATION, TIME, TEMPERATURE, PH AND META-DATA. IN PHASE I, WE REDESIGNED THE INSTRUMENT USING AN 'INTERNET OF THINGS' DEVELOPMENT PLATFORM, MODIFIED THE APP TO OPERATE ON BOTH ANDROID AND IOS PHONES, AND SHOWED, THROUGH A NETWORK OF PARTNERS, THAT IT IS AN EXCELLENT TOOL FOR COASTAL PH MEASUREMENTS, EDUCATION, AND CITIZEN SCIENCE. WITH THIS TECHNOLOGY, WE HAVE THE BASIS TO DEVELOP INEXPENSIVE INSTRUMENTATION FOR CITIZEN SCIENTISTS AND STUDENTS TO MEASURE OTHER IMPORTANT WATER QUALITY PARAMETERS, SUCH AS TOTAL ALKALINITY (TA), FLUORESCENT DISSOLVED ORGANIC MATTER (FDOM), THE PARTIAL PRESSURE OF CO2 (PCO2), AND THE DIFFERENTIAL PRESSURE OF CO2 IN AIR/WATER (DCO2). WITH PHASE II FUNDING WE WILL DEVELOP INEXPENSIVE TA, FDOM, PCO2, AND DCO2 MEASUREMENT SYSTEMS, AND A 'PHYTERPRO' (HIGHER ACCURACY PHYTER), WHILE WORKING CLOSELY WITH EDUCATORS

DIRECTED GRANTS

SBIR PHASE II: UV LED LAMP BASED WATER DISINFECTION FOR POU COMPACT PURIFICATION SYSTEMS

OPTIMIZED CROP IRRIGATION USING A COST-EFFECTIVE IN-SITU NMR SOIL WATER PROBE

OPTICAL FIBER SENSOR FOR PLANT NUTRIENTS

STEVENSON CARSON SCHOOL DISTRICT IS WORKING WITH DAVID CORR, A SECURITY CONSULTANT TO BRING THE SCHOOL DISTRICT UP TO A MORE SECURE STATE THAN THE CURRENT SITUATION. THIS UPDATING BEGAN LAST SUMMER WITH SMALL, EASY UPGRADES WHILE THE BIGGER PICTURE, LARGER PROJECTS WERE DETERMINED. THERE WILL CONTINUE TO BE MORE PROJECTS AFTER THE GRANT PERIOD BUT A LARGE CHUNK OF COSTS ARE PROPOSED WITHIN THIS GRANT APPLICATION. THE APPLICATION CONTAINS REQUESTS FOR: MANY MORE CAMERAS; A BULLET PROOF LAMINATE/FILM TO APPLY TO WINDOWS; PA SYSTEM UPGRADES THAT WILL ASSIST WITH EMERGENCY SITUATIONS; THE CONSULTANT; HARDENING OF WALLS/PLATING; ADDING A LAYER TO SEVERAL SCHOOLS TO REQUIRE PERMISSIVE ACCESS AND CARD READER DOOR ACCESS POINTS; AND A CHAIN LINK FENCE AROUND A DIFFICULT PART OF THE HIGH SCHOOL TO SECURE. SOME OF THIS WILL BE PAID FOR BY OUR ENTITY AND THE REST BY THE GRANT. THIS LAST MONTH HAS BEEN VERY CHALLENGING TO OUR SCHOOL DISTRICT. WE HAVE HAD LOCK DOWNS, LOCK OUTS, WE HAD TO CANCEL ONE SCHOOL DAY BECAUSE OF THE EXHAUSTIVE ISSUES. WE EVEN MADE THE NEWS. THIS IS A SMALL SCHOOL DISTRICT (CURRENTLY 780 STUDENTS IN 4 SCHOOLS) WITH AN EVER INCREASING ARRAY OF CHALLENGES. THESE CHANGES WILL HELP THE SCHOOL DISTRICT MEET THE SECURITY GOALS DETERMINED BY THE CONSULTANT, COMMUNITY AND SCHOOL BOARD. THE 4 SCHOOLS ARE DIVIDED INTO 2 COMMUNITIES. STEVENSON IS THE CITY PROPER AND IT HOLDS THE YOUNGEST ELEMENTARY SCHOOL TTK-2ND GRADE AND THE HIGH SCHOOL 9TH-12TH GRADE. CARSON IS ON THE OUTSKIRTS OF STEVENSON WITH THE OLDER ELEMENTARY 3RD-5TH GRADE AND THE MIDDLE SCHOOL 6TH-8TH GRADE. THE PROJECTS ARE VARIED PER SCHOOL BASED ON NEEDS. THE OUTCOMES: SCHOOL BUSINESS CAN BE CONDUCTED WITHOUT ACCESS INTO SCHOOL; MORE CAMERA FOOTAGE TO DETERMINE ISSUES; INCREASED PROTECTION FROM POSSIBLE ATTACKS WITH PROTECTIVE LAYERS; LIMITED ACCESS USING CARD READERS VERSUS KEYS THAT ARE NOT RETURNED; QUICKER/CONSISTENT RESPONSE WITH UPGRADED PA SYSTEMS. THE CONSULTANT AND THE SHERIFF ARE WORKING WITH THE SCHOOL DISTRICT ON THE EMERGENCY OPERATING PROCEDURES AND UPDATING AS BOTH PLANNED DRILLS AND THE UNFORTUNATE NON-DRILLS CONTINUE TO TAKE PLACE IN THE DISTRICT.

PERFORM FUNDING SYS

IMPROVE EXISTING AIRPORT

DETECT THE LESSER GRAIN BORER IN STORED GRAIN USING AN APPLICATION OF A NEW SCIENCE AND TECHNOLOGY PHASE II

PERFORM FUNDING SYS

DEVELOPOMENT OF HERMAL HISTORY COATING TECHNOLOGY

PURPOSE: UPDATE AIRPORT MASTER PLAN. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT UPDATES THE EXISTING AIRPORT MASTER PLAN STUDY. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH BENSON, ARIZONA.

DOMESTIC WATER GRANTS - REGULAR

CAPITAL AND MANAGEMENT ACTIVITIES (FORMULA)

COMMUNITY INFRASTRUCTURE

ASSISTANCE TO FIREFIGHTERS GRANT

SBIR PHASE II: DEVELOPMENT AND COMMERCIALIZATION OF NITRATE-SELECTIVE SENSORS FOR PRECISION AGRICULTURE

DOMESTIC WATER GRANTS - REGULAR

PUBLIC HOUSING CAPITAL FUND

NOVEL, LOW COST, HIGH GAIN, MICROPATTERN DETECTORS

PUBLIC HOUSING CAPITAL FUND

IMPROVE EXISTING AIRPORT

SBIR PHASE II: METAMATERIALS FOR GIANT DIELECTRICS AND ENERGY STORAGE SOLUTIONS

FORENSIC STUDIES AND TRAINING PROGRAM

NEW COOPERATIVE AGREEMENT: 3D TERRAIN MAPPING USING COORDINATED UAV PLATFORMS

A SMART SEMICONDUCTOR BASED INTEGRATED CONTINUOUS DIABETES MONITORING PLATFORM - PROJECT SUMMARY THE LONG-TERM GOAL OF THIS PROJECT IS TO DEVELOP A SCALABLE, USER-FRIENDLY, CONTINUOUS DIABETES MONITORING (CDM) SYSTEM TO MINIMIZE THE RISK OF DIABETIC KETOACIDOSIS (DKA) FOR MILLIONS OF DIABETES PATIENTS, ESPECIALLY THOSE WITH TYPE I DIABETES BY ADDING CONTINUOUS KETONE MONITORING (CKM) TO THE IMS CONTINUOUS GLUCOSE MONITOR (CGM). IMS HAS DEVELOPED THE WORLD'S SMALLEST WIRELESS ELECTROCHEMICAL CGM USING A NOVEL SEMICONDUCTOR (CMOS) PLATFORM. THIS DESIGN OFFERS SOME UNIQUE ADVANTAGES DUE TO ITS SMART SENSOR (COMPARED TO PASSIVE SENSORS IN COMPETITOR DESIGNS) INCLUDING EXTREME MINIATURIZATION (SYSTEM IS SMALLER THAN HALF A SESAME SEED), ON-CHIP INTEGRATION OF MULTIPLE SENSORS, IMPROVEMENT IN SIGNAL-TO-NOISE RATIO (THUS IMPROVING HYPOGLYCEMIA ACCURACY), DECREASE IN SENSOR CAPACITANCE AND MEMBRANE THICKNESS (THUS IMPROVING RESPONSE SPEED), AND ON-CHIP TEMPERATURE CALIBRATION. THIS SYSTEM CAN ENABLE AUTOMATIC CLOSED-LOOP GLUCOSE CONTROL WITHOUT MEAL ANNOUNCEMENTS AND CARBOHYDRATE COUNTING AND WITHOUT THE FEAR OF MISSED HYPOGLYCEMIC EVENTS; GREATLY SIMPLIFYING PATIENT EXPERIENCE AND IMPROVING SAFETY. WE HAVE DEMONSTRATED THE FUNCTION OF OUR CGM PLATFORM IN THE LAB, IN ANIMALS, AND RECENTLY IN HUMANS. THE ADDITION OF CKM CAN SIGNIFICANTLY IMPROVE THE VALUE OF THE SYSTEM TO DETECT IMPENDING DKA THAT GOES UNNOTICED WITH THE CURRENT CGM SYSTEMS, CAUSING SIGNIFICANT HARM TO THE AT-RISK PATIENTS. THEREFORE, OUR OBJECTIVE IN THE ORIGINAL PROPOSAL WAS TO DEVELOP A MULTI-ANALYTE SENSING PLATFORM THAT CAN SENSE BOTH GLUCOSE AND KETONE IN THE INTERSTITIAL FLUID (ISF) USING A SINGLE DEVICE. THE SENSING PLATFORM WOULD BE TESTED IN THE LAB. THIS RESEARCH IS SIGNIFICANT AS IT WILL ENABLE THE FIRST CDM SYSTEM WITH A SMALL, PAIN-FREE NEEDLE- INSERTION (26-GAUGE NEEDLE) THAT CAN WORK FOR A LONG TIME (>30 DAYS). ONCE PROVEN, THIS SYSTEM CAN BE EXTENDED TO INCLUDE OTHER IMPORTANT ANALYTES (E.G., INSULIN, GLUCAGON) WITHOUT INCREASING ITS SIZE OR COMPLEXITY, OWING TO ON-CHIP INTEGRATION OF MULTIPLE SENSORS ON A SINGLE MICROSCALE DEVICE. DURING OUR WORK, WE DISCOVERED AN UNFORESEEN ISSUE WITH THE KETONES SENSING CHEMISTRY THAT PREVENTS LONG-TERM STABILITY. WE HAVE DISCOVERED A POTENTIAL SOLUTION TO THAT BY USING A CONJUGATED ENZYME. WE NEED ADDITIONAL SUPPORT VIA THIS SUPPLEMENT TO ENABLE US TO TEST THIS SOLUTION. THE TEAM INCLUDES ORIGINAL INVENTORS OF THE CORE TECHNOLOGY FROM CALIFORNIA INSTITUTE OF TECHNOLOGY (DR. NAZARI, DR. RAHMAN, MR. SENCAN), SEASONED AND RESPECTED RESEARCHER IN GLUCOSE SENSOR TECHNOLOGY (BILL VAN ANTWERP, FORMER CSO OF MEDTRONIC MINIMED), SURGERY AND BIOMATERIALS EXPERT (DR. JONATHAN LAKEY OF UC IRVINE), REGULATORY AND IP EXPERT (JOHN HEITHAUS, JD), COMMERCIALIZATION EXPERT (MR. PETER RULE; FORMER PRESIDENT OF MINIMED, CHAIRMAN OF THERASENSE, AND OPTISCAN), AND CLINICAL EXPERT (DR. ALAN MARCUS, MD; FORMER CHIEF MEDICAL OFFICER OF MEDTRONIC DIABETES). THE PROJECT IS SUPPORTED BY PATIENT ADVOCACY GROUPS LIKE JDRF AND PRACTICING ENDOCRINOLOGISTS LIKE DR. ANNE PETERS.

THIS AWARD PROVIDES FUNDING TO CONDUCT BROWNFIELD HAZARDOUS SUBSTANCES AND PETROLEUM ASSESSMENTS AT POTENTIAL BROWNFIELD SITES. THE RECIPIENT WILL C

AUTOMATED TAG LIBRARY GENERATION FOR SEQUENCING-BASED GENE EXPRESSION PROFILING

NOVEL APPROACHES FOR PROTAC DRUG DISCOVERY

PUBLIC HOUSING CAPITAL FUND

RURAL HEALTH CARE SERVICES OUTREACH GRANT PROGRAM

IMPROVE EXISTING AIRPORT

IMPROVE EXISTING AIRPORT

PUBLIC HOUSING CAPITAL FUND

STAFFING FOR ADEQUATE FIRE AND EMERGENCY RESPONSE (SAFER)

A MINIATURIZED AND INTEGRATED CONTINUOUS METABOLIC MONITORING PLATFORM - PROJECT SUMMARY THE LONG-TERM GOAL OF THIS PROJECT IS TO DEVELOP A SCALABLE, USER-FRIENDLY, CONTINUOUS METABOLIC MONITORING (CMM) SYSTEM TO IMPROVE THE PERFORMANCE AND RELIABILITY OF HORMONE REPLACEMENT THERAPY FOR MILLIONS OF DIABETES PATIENTS. IMS HAS DEVELOPED THE WORLD'S SMALLEST WIRELESS ELECTROCHEMICAL ANALYTE SENSING PLATFORM BASED ON AN APPLICATION-SPECIFIC INTEGRATED CIRCUIT (ASIC) USING COMPLEMENTARY METAL-OXIDE SEMICONDUCTOR (CMOS) TECHNOLOGY. THIS DESIGN OFFERS SOME UNIQUE ADVANTAGES DUE TO ITS ACTIVE DIGITAL SENSOR (COMPARED TO PASSIVE ANALOG SENSORS IN COMPETITOR DESIGNS) INCLUDING EXTREME MINIATURIZATION, ON-CHIP INTEGRATION OF MULTIPLE SENSORS, IMPROVEMENT IN SIGNAL-TO- NOISE (SNR) RATIO (THUS IMPROVING HYPOGLYCEMIA ACCURACY), DECREASE IN SENSOR CAPACITANCE AND MEMBRANE THICKNESS (THUS IMPROVING RESPONSE SPEED), UNIVERSAL INTERFERENCE REJECTION (USING A BACKGROUND REFERENCE SENSOR AND SUBTRACTING ITS SIGNAL FROM ALL SENSORS), AND ON-CHIP TEMPERATURE CALIBRATION (IMPROVE ACCURACY, RELIABILITY BY CONFIRMING THE SENSOR IS IN THE TISSUE AND MEASURING THE CORRECT TEMPERATURE). THE PROPOSED CMM WILL ENABLE USERS TO BENEFIT FROM USEFUL DRUGS (E.G., METFORMIN, SGLT2 INHIBITORS), EXERCISE, AND AUTOMATED INSULIN DELIVERY SYSTEMS WITHOUT MEAL ANNOUNCEMENTS, CARBOHYDRATE COUNTING, AND THE RISK OF ADVERSE SIDE EFFECTS. HENCE, THE DESIGN IS HIGHLY INNOVATIVE. WE HAVE DEMONSTRATED THE FUNCTION OF THE FIRST-GENERATION PLATFORM FOR CONTINUOUS GLUCOSE MONITORING (CGM) IN HUMANS. CONTINUOUS LACTATE MONITORING (CLM) CAN SIGNIFICANTLY IMPROVE THE SYSTEM'S VALUE TO DETECT IMPENDING LACTIC ACIDOSIS THAT GOES UNNOTICED WITH THE CURRENT CGM SYSTEMS. WE HAVE DEMONSTRATED THE CLM IN ANIMALS AND A MULTIPLEXED CGM-CLM AT THE PROPOSED SIZE SCALE IN THE LAB. OUR OBJECTIVE IN THIS PROPOSAL IS TO DEVELOP A CMM THAT CAN SENSE GLUCOSE, LACTATE, AND TEMPERATURE IN THE INTERSTITIAL FLUID (ISF) USING A SINGLE WIRELESS SENSOR SMALLER THAN HALF A SESAME SEED. THE SMALL AND FLEXIBLE (20UM THICK WITH POLYMER COATINGS) SENSOR MINIMIZES THE FOREIGN BODY RESPONSE (FBR). THIS RESEARCH IS SIGNIFICANT AS IT WILL ENABLE THE FIRST CMM SYSTEM CAPABLE OF A SMALL, PAIN-FREE NEEDLE INSERTION (26-GAUGE NEEDLE) THAT CAN WORK FOR A LONG TIME (>30 DAYS) WITH FACTORY CALIBRATION (NO FINGER STICKS). ONCE PROVEN, THIS SYSTEM CAN BE EXTENDED TO INCLUDE OTHER IMPORTANT ANALYTES (E.G., KETONES, INSULIN, GLUCAGON) WITHOUT INCREASING ITS SIZE, OWING TO THE ON-CHIP INTEGRATION OF MULTIPLE SENSORS. THE TEAM INCLUDES ORIGINAL INVENTORS OF THE CORE TECHNOLOGY FROM THE CALIFORNIA INSTITUTE OF TECHNOLOGY (DR. NAZARI, DR. RAHMAN, MR. SENCAN), A SEASONED AND RESPECTED RESEARCHER IN ELECTROCHEMICAL SENSOR TECHNOLOGY (BILL VAN ANTWERP, FORMER CSO OF MEDTRONIC MINIMED), BIOMATERIALS EXPERT (DR. JONATHAN LAKEY OF UC IRVINE), REGULATORY AND IP EXPERT (JOHN HEITHAUS, JD), COMMERCIALIZATION EXPERT (MR. PETER RULE; FORMER PRESIDENT OF MINIMED, CHAIRMAN OF THERASENSE, AND OPTISCAN), CLINICAL EXPERTS (DR. ALAN MARCUS, MD; FORMER CHIEF MEDICAL OFFICER OF MEDTRONIC DIABETES), AND IMPLANTABLE BIOSENSORS AND LACTATE MONITORING EXPERT (DR. NATALIE WISNIEWSKI, PH.D., FORMER CTO OF PROFUSA, INC.).

A NEW NANO BASED REAL-TIME AFLATOXIN DETECTOR PHASE II

PUBLIC AND INDIAN HOUSING

PUBLIC AND INDIAN HOUSING

PUBLIC AND INDIAN HOUSING

IMPROVE EXISTING AIRPORT C

CAPITAL FUND PROGRAM

CAPITAL FUND PROGRAM

CAPITAL FUND PROGRAM

PURPOSE: THE PUBLIC HOUSING OPERATING FUND (PH OPFUND) PROVIDES OPERATING SUBSIDIES TO HOUSING AUTHORITIES (HAS) TO ASSIST IN FUNDING THE OPERATING AND MAINTENANCE EXPENSES OF THEIR DWELLINGS, IN ACCORDANCE WITH SECTION 9 OF THE U.S. HOUSING ACT OF 1937, AS AMENDED. THE SUBSIDIES ARE REQUIRED TO HELP MAINTAIN SERVICES AND PROVIDE MINIMUM OPERATING RESERVES. THE PH OPFUND IS A $5 BILLION DOLLAR PROGRAM PROVIDING FUNDING TO APPROXIMATELY 6,000 HAS SERVING 1,590,321 PUBLIC HOUSING RESIDENTS IN 902,436 HOUSEHOLDS (44% ARE ELDERLY AND 35% OF RESIDENTS HAVE CHILDREN). INFORMATION ON THE CURRENT OPERATING FUND GRANT PROCESSING CAN BE FOUND AT HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/PUBLIC_INDIAN_HOUSING/PROGRAMS/PH/AM/FUNDING.; ACTIVITIES TO BE PERFORMED: OPERATING FUNDS ARE USED TO FUND DAY-TO-DAY OPERATIONAL EXPENSES ASSOCIATED WITH PUBLIC HOUSING AS WELL AS THE ADMINISTRATIVE AND PROGRAM IMPLEMENTATION EXPENSES THAT PUBLIC HOUSING AGENCIES (PHAS) ARE REQUIRED TO UNDERTAKE UNDER THE 1937 HOUSING ACT AND PROGRAM REGULATIONS. SUCH ACTIVITIES INCLUDE MANAGEMENT AND OPERATIONS, ROUTINE AND PREVENTATIVE MAINTENANCE, ANTI-CRIME, ANTI-DRUG AND SECURITY ACTIVITIES, OPERATING COSTS FOR PRIVATELY OWNED PUBLIC HOUSING UNITS WITHIN MIXED-FINANCE PROJECTS, ENERGY COSTS, RESIDENT SUPPORTIVE SERVICES, INSURANCE, DEBT SERVICE AND COSTS ASSOCIATED WITH ADMINISTRATION AND PROGRAM IMPLEMENTATION. TURNKEY III PROJECTS ARE FUNDED FOR UNITS UNDER THE FINAL LEASE PURCHASE AGREEMENT FOR CLOSING OUT THE PROGRAM. TO SUPPORT THESE ACTIVITIES, THERE IS CONTINUED MODERNIZATION OF THE INFORMATION TECHNOLOGY PLATFORMS. PHAS HAVE ACCESS TO WEB-BASED PLATFORMS THAT UTILIZE REAL-TIME DATA TO PROVIDE INSIGHT INTO THEIR PORTFOLIOS. PHAS CAN OBTAIN METRICS ON THEIR FUNDING LEVELS, OCCUPANCY RATES, AND THE NUMBER OF FAMILIES SERVED THROUGH RENTAL ASSISTANCE.; EXPECTED OUTCOMES: AS A RESULT OF THE ACTIVITIES PERFORMED, THIS PROGRAM IS EXPECTED TO ASSIST IN FUNDING THE OPERATING AND MAINTENANCE EXPENSES. THIS MAY INCLUDE INCREASED OCCUPANCY IN PUBLIC HOUSING, DECREASED ENERGY COSTS THROUGH REGULAR MAINTENANCE AND ENERGY PERFORMANCE CONTRACTING AND LEVERAGE FEDERAL RESOURCES. IN ADDITION TO ADDRESSING THE DEPARTMENT’S STRATEGIC GOALS OF: • ADDRESSING THE NEED FOR QUALITY AFFORDABLE RENTAL HOMES BY MAINTAINING OR IMPROVING UPON THE 96% OCCUPANCY RATE OF HABITABLE UNITS; • PROMOTING HOUSING AS A PLATFORM TO IMPROVE QUALITY OF LIFE THROUGH SUPPORTIVE SERVICES, CRIME PREVENTION EFFORTS AND RESIDENT ENGAGEMENT ACTIVITIES; AND • HELPING TO BUILD INCLUSIVE COMMUNITIES FREE FROM DISCRIMINATION BY FACILITATING THE IMPLEMENTATION OF AFFIRMATIVELY FURTHERING FAIR HOUSING MEASURES.; INTENDED BENEFICIARIES: THE OPERATING FUND PROVIDES FOR THE OPERATION AND MAINTENANCE OF LOW-INCOME HOUSING PROJECTS TO PHAS/PROJECTS. IT WAS CREATED TO ASSIST HOUSING AUTHORITIES IN PROVIDING DECENT AND SAFE RENTAL HOUSING FOR ELIGIBLE LOW-INCOME FAMILIES OR INDIVIDUALS, THE ELDERLY, AND PERSONS WITH DISABILITIES. A HA DETERMINES ELIGIBILITY BASED ON 1) ANNUAL GROSS INCOME; 2) A PERSON ON WHO IS ELDERLY, A PERSON WITH A DISABILITY, OR AS A FAMILY; AND 3) U.S. CITIZENSHIP OR ELIGIBLE IMMIGRATION STATUS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

SUMO FUSION TECHNOLOGY FOR EUKARYOTIC PROTEIN EXPRESSION SYSTEMS

PUBLIC AND INDIAN HOUSING

PUBLIC AND INDIAN HOUSING

PUBLIC HOUSING CAPITAL FUND

CAPITAL FUND PROGRAM

PUBLIC AND INDIAN HOUSING