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TAS::89 0328::TAS RECOVERY ACT - OE SMART GRID DEMONSTRATION AWARD TO BEACON POWER CORPORATION

SPINA BIFIDA ASSOC- NAT'L SPINA BIFIDA INITIATI: PREVENT, RESOU & QUALITY OF LIFE

THE MAIN OBJECTIVE OF THIS PROJECT IS TO DESIGN, DEVELOP, AND PILOT-DEMONSTRATE A SUPERIOR ELECTROSPUN NANOFIBER-BASED SEPARATOR FOR LIQUID ALKALINE ELECTROLYZER (LAE) SYSTEM. THIS DURABLE SEPARATOR WILL HAVE LOW THICKNESS, LOW RESISTANCE, HIGH ION TRANSPORT EFFICIENCY, LOW GAS CROSSOVER, AND HIGH MECHANICAL STRENGTH. IT WILL BE COMPETITIVELY PRICED AND WILL BE A DIRECT DROP-IN REPLACEMENT FOR ZIRFON®. THE PROJECT TEAM WILL PERFORM FIELD DEMONSTRATIONS AT A LARGE SITE WITH A UNIQUE DESIGN APPROACH. THE SUCCESSFUL COMPLETION OF THE PROJECT WILL BRING TO MARKET, NEW PRODUCT, LOCALLY MANUFACTURED IN CHATTANOOGA, TN, FOR EXPANDING HYDROGEN ECONOMY AND DECARBONIZATION OF INDUSTRIES, WHILE CREATING ROBUST MANUFACTURING BASE IN US AND PROMOTING LOCAL ECONOMIC DEVELOPMENT.

HIGH-RESOLUTION MAGNETOENCEPHALOGRAPHY USING ATOMIC MAGNETRODES

GLP TOXICOLOGY TESTING AND PHASE 2/3 DEVELOPMENT FOR A NONOPIOID, INJECTABLE DRUG PRODUCT FOR THE TREATMENT OF LUMBOSACRAL RADICULOPATHY (SCIATICA)

THE CONTINUED DEVELOPMENT AND IMPLEMENTATION OF THE SPINA BIFIDA COLLABORATIVE CARE NETWORK

SPINDLETOP CENTER CCBHC PROJECT - SPINDLETOP CENTER HAS SERVED AS THE LOCAL MENTAL HEALTH AUTHORITY FOR A FOUR-COUNTY AREA INCLUDING JEFFERSON, HARDIN, ORANGE, AND CHAMBERS COUNTIES IN SOUTHEAST TEXAS FOR OVER 45 YEARS. SINCE 2005 WHEN THE COMMUNITY WAS DEVASTATED BY HURRICANE RITA, THIS SAME SERVICE AREA HAS BEEN IMPACTED BY NINE TROPICAL STORMS AND HURRICANES, MOST NOTABLY HURRICANE HARVEY IN 2017, AS REPORTED BY THE NATIONAL HURRICANE CENTER. BASED ON A COMMUNITY NEEDS ASSESSMENT COMPLETED BY STC IN 2020, THERE ARE APPROXIMATELY 2 LOCAL BEHAVIORAL HEALTH HOSPITALS, 15 FEDERALLY QUALIFIED HEALTH CLINICS, 4 PUBLIC HEALTH DEPARTMENTS, AND A VA CLINIC IN BEAUMONT. STC HAS APPLIED TO TEXAS HEALTH AND HUMAN SERVICES COMMISSION TO PURSUE CERTIFIED COMMUNITY BEHAVIORAL HEALTH CLINIC (CCBHC) STATUS. THE CCBHC MODEL OF CARE ALIGNS WITH THE STC MISSION OF HELPING PEOPLE HELP THEMSELVES BY PROVIDING RESOURCES AND SUPPORTS. IN ADDITION TO THE NEED FOR THE COMPREHENSIVE SERVICE ARRAY WHICH A CCBHC MODEL OF CARE WILL ENSURE, THE INDIVIDUALS LIVING IN THE SERVICE AREA CLEARLY NEED THE BENEFIT OF CARE COORDINATION TO ASSIST THEM IN ACCESSING THE RIGHT CARE AT THE RIGHT TIME TO ADDRESS THE HEALTH CONCERNS OF THE WHOLE PERSON. IN FISCAL YEAR 2020, STC SERVED 12,718 UNDUPLICATED INDIVIDUALS IN ALL SERVICES COMBINED WITH 45.9% OF ADULTS UNINSURED AND 16% OF CHILDREN UNINSURED. STC PROPOSES TO UTILIZE THIS GRANT FUNDING TO INCREASE ACCESS TO CARE FOR CHILDREN AND ADULTS WITH SERIOUS MENTAL ILLNESS OR SERIOUS EMOTIONAL DISTURBANCE AND INDIVIDUALS WITH SUBSTANCE USE DISORDERS WHO ARE IDENTIFIED AS LOW-INCOME OR UNINSURED. STC PROPOSES TO SERVE APPROXIMATELY 13,650 UNDUPLICATED INDIVIDUALS OVER THE LIFE OF THE GRANT.

CONNECTED CATHETER CLINICAL VALIDATION STUDY (CVS)

COMP A-DEVELOPING THE SPINA BIFIDA COLLABORATIVE CARE NETWORK

HIGH-RISK, LOW-COST CARBON NANOFIBER MANUFACTURING PROCESS SCALE-UP

DEVELOPMENT OF A NOVEL, REGENERATIVE THERAPY TO REVERSE SYNAPSE LOSS IN ALZHEIMER'S DISEASE - PROJECT SUMMARY/ABSTRACT THE MISSION OF THE SBIR PROGRAM IS TO “ENCOURAGE DOMESTIC SMALL BUSINESSES TO ENGAGE IN FEDERAL RESEARCH/RESEARCH AND DEVELOPMENT (R/R&D) THAT HAS THE POTENTIAL FOR COMMERCIALIZATION.” A MISSION OF THE NIA IS TO “SUPPORT RESEARCH ON ALZHEIMER’S DISEASE, AND PROMOTE RESEARCH ON THE ETIOLOGY, TREATMENT, AND DIAGNOSIS OF AD”. THE PROPOSED DEVELOPMENT PROGRAM IS NECESSARY TO ENABLE THE FILING AND ACCEPTANCE OF AN IND WITH THE FDA, AN EARLY PRELUDE TO COMMERCIALIZATION. THE THREE SPECIFIC AIMS OF THIS DEVELOPMENT GRANT ARE: 1. GMP MANUFACTURE OF AN ORAL DOSAGE FORM OF SPG302, A NOVEL SYNAPTOGENIC MOLECULE. 2. CONDUCT GLP SAFETY PHARMACOLOGY STUDIES AND CONDUCT GLP IND-ENABLING TOXICOLOGY STUDIES IN RATS AND BEAGLE DOGS FOR 4 WEEKS WITH SPG302 3. PREPARE AND SUBMIT A SUCCESSFUL IND REQUEST TO THE FDA. THE PROPOSED STUDIES ARE DESIGNED TO OPTIMIZE TIME AND RESOURCES WHILE MOVING STEP WISE THROUGH SAFETY TESTS, RESULTING IN AN IND SUBMISSION (FOR PHASE 1 SINGLE ASCENDING DOSE, MULTIPLE ASCENDING DOSE AND FOOD INTERACTION STUDIES) WITHIN 24 MONTHS OF THE GRANT BEING FUNDED. SPINOGENIX WILL WORK WITH A CRO TO ASSEMBLE THE CMC, PHARMACOLOGY AND TOXICOLOGY INFORMATION AND TO PREPARE AND SUBMIT AN ELECTRONIC IND TO THE FDA.

ESPIN TECHNOLOGIES, INC. WITH NATIONAL RENEWABLE ENERGY LABORATORY - NEW OPEN 2021 COOPERATIVE AGREEMENT. CONTROL NUMBER: 2459-1604 TITLE: ''INCORPORATING RECORD-BREAKING CATALYSTS IN ELECTROSPUN BIPOLAR MEMBRANES FOR LOW-COST CARBON CAPTURE VIA SALT SPLITTING''

COMMERCIALIZATION READINESS OF WEARABLE OPTICALLY PUMPED MAGNETOENCEPHALOGRAPHY - ABSTRACT MAGNETOENCEPHALOGRAPHY (MEG) HAS ESTABLISHED ITSELF AS AN INDISPENSABLE TOOL FOR FUNCTIONAL BRAIN IMAGING, OFFERING UNPARALLELED SPATIAL AND TEMPORAL RESOLUTION WHILE BEING NON-INVASIVE. DESPITE ITS ADVANTAGES, CURRENT MEG SYSTEMS BASED ON SUPERCONDUCTING QUANTUM INTERFERENCE DEVICES (SQUIDS) ARE COST-PROHIBITIVE AND LACK ADAPTABILITY, PARTICULARLY FOR PEDIATRIC POPULATIONS. THIS PROJECT FOCUSES ON THE DEVELOPMENT OF A WEARABLE MEG SYSTEM BASED ON OPTICALLY PUMPED MAGNETOMETER (OPM) TECHNOLOGY, A NOVEL ALTERNATIVE TO TRADITIONAL SQUID MAGNETOMETERS. THIS INNOVATION ELIMINATES THE NEED FOR CRYOGENIC COOLING, THEREBY OVERCOMING SIGNIFICANT LIMITATIONS ASSOCIATED WITH TRADITIONAL MEG SYSTEMS. USING OPMS HAS ENABLED THE DEVELOPMENT OF A COST-EFFECTIVE, FLEXIBLE, AND HIGH-RESOLUTION MEG SYSTEM (OPM-MEG). OUR TECHNOLOGY AIMS TO MATCH THE SPATIAL RESOLUTION OF INVASIVE TECHNIQUES SUCH AS ELECTROCORTICOGRAPHY (ECOG), WHILE MAINTAINING THE NON-INVASIVE NATURE OF TRADITIONAL MEG. ADDITIONALLY, IT FEATURES A FLEXIBLE HELMET, ACCOMMODATING INDIVIDUALS OF ALL AGES AND ALLOWING FOR HEAD MOVEMENT DURING SCANNING—AN IMPORTANT ADVANCEMENT IN NEUROIMAGING TECHNOLOGIES. BUILDING ON OUR SUCCESSFUL PHASE IIB PROJECT, WHERE WE DEVELOPED AND DEPLOYED PROTOTYPE HIGH-DENSITY OPM-MEG SYSTEMS IN LEADING NEUROSCIENCE LABORATORIES, THE CURRENT PROJECT AIMS TO FINALIZE THE ESSENTIAL STEPS FOR THE COMMERCIALIZATION OF THIS GROUNDBREAKING TECHNOLOGY.

NEW SBIR PHASE I 2009: RADIATION HARD GAAS PHOTOMULTIPLIER CHIP(TM); PI - ERIC SPANGLER HARMON

SUSATINED-RELEASE INJECTIBLE STEROID TO REDUCE FREQUENT EPIDURAL INJECTIONS FOR BACK PAIN

TRANSFORMATION OF DORMANT SPINAL NETWORKS TO MITIGATE SYMPTOMS OF NEUROGENIC BLADDER - SUMMARY SPINAL CORD INJURY INVARIABLY LEADS TO SEVERE DYSFUNCTION OF THE LOWER URINARY TRACT; PATIENTS DEVELOP URINARY INCONTINENCE, RECURRENT URINARY TRACT INFECTIONS, INCOMPLETE BLADDER EMPTYING AND HIGH BLADDER PRESSURES. RELIANCE ON CATHETERS TO EMPTY THE BLADDER IS VIRTUALLY UNIVERSAL. ESTABLISHED THERAPIES FOR LOWER URINARY TRACT DYSFUNCTION DUE TO SPINAL CORD INJURY FOCUS ON PREVENTING AND MANAGING COMPLICATIONS RATHER THAN ON RESTORING FUNCTION. RELYING ON OUR YEARS OF EXPERIENCE IN REHABILITATION OF MOTOR FUNCTION AFTER PARALYSIS, WE ARE CONFIDENT THAT WE CAN CHANGE THE PARADIGM OF BLADDER CARE IN INDIVIDUALS WITH SPINAL CORD INJURIES AS WELL. TRANSCUTANEOUS ELECTRICAL SPINAL CORD NEUROMODULATION (TESCON) OFFERS A DIAMETRICALLY DIFFERENT APPROACH TO CLASSIC THERAPIES FOR NEUROGENIC BLADDER: BY DELIVERING LOW-INTENSITY SUB-MOTOR THRESHOLD ELECTRICAL PULSES TO THE SPINAL CORD, TESCON ACTIVATES LUMBAR NEURAL NETWORKS RENDERED DYSFUNCTIONAL BY THE SPINAL CORD INJURY AND RESTORES SOME COMMUNICATION BETWEEN THE LOWER URINARY TRACT AND HIGHER NEURAL CENTERS RESPONSIBLE FOR MICTURITION CONTROL. RESULTS FROM OUR PRELIMINARY STUDIES INDICATE THAT TESCON-MEDIATED NEUROMODULATION IMPROVES BLADDER CAPACITY, DIMINISHES URINARY INCONTINENCE AND, REMARKABLY, RESTORES BLADDER SENSATION EVEN IN INDIVIDUALS, WHOSE SPINAL CORD INJURY IS CONSIDERED CLINICALLY COMPLETE. IN THIS PHASE II APPLICATION, WE PROPOSE TO BUILD A COMMERCIAL VERSION OF THE TESCON PROTOTYPE UNDER DESIGN CONTROLS AND USE THE DEVICE IN A CLINICAL VALIDATION STUDY. WE PROPOSE A MULTICENTER RANDOMIZED CONTROL TRIAL TO DEMONSTRATE THE BENEFICIAL EFFECTS OF TESCON ON THE PARALYZED LOWER URINARY TRACT. BY RECRUITING SIXTY INDIVIDUALS WITH SPINAL CORD INJURY AND COMPARING THE EFFECTS OF SHAM AND TRUE STIMULATION ON THEIR LOWER URINARY TRACT, WE AIM TO SHOW THAT TESCON HAS A SIGNIFICANT ROLE IN MANAGING AND REHABILITATING URINARY FUNCTION IN THE CLINICAL SETTING (PRIMARY OUTCOME). THE ACADEMIC ROOTS OF OUR COMPANY AND THE TEAM WE HAVE ASSEMBLED (ENGINEERS, ENTREPRENEURS AND CLINICIANS) ENSURE THAT OUR STUDY DESIGN, IMPLEMENTATION AND ANALYSIS WILL BE BOTH IMPACTFUL AND RIGOROUS. SUCCESSFUL COMPLETION OF THIS STUDY WILL PROVIDE EVIDENCE FOR A FDA 510(K) SUBMISSION. FINALLY, IF TESCON IS SUCCESSFUL IN THE CASE OF A NEUROLOGICAL IMPAIRMENT AS DEVASTATING AS A SPINAL CORD INJURY, WE ARE CONFIDENT THAT WE WILL BE ABLE TO BRING THIS TECHNOLOGY TO A MUCH LARGER POPULATION OF PATIENTS SUFFERING FROM LOWER URINARY TRACT DYSFUNCTION DUE TO BOTH NEUROLOGICAL AND NON-NEUROLOGICAL CONDITIONS, SUCH AS STROKE, MULTIPLE SCLEROSIS, PARKINSON’S DISEASE AND IDIOPATHIC OVERACTIVE BLADDER.

SPINAL CORD INNOVATION IN PEDIATRICS TO TREAT CEREBRAL PALSY (SCIP CLINICAL STUDY) - SUMMARY CEREBRAL PALSY (CP) IS THE MOST COMMON MOTOR DISABILITY IN CHILDHOOD. POPULATION-BASED STUDIES FROM AROUND THE WORLD REPORT PREVALENCE ESTIMATES RANGING FROM 1.5 TO 4 PER 1000 INDIVIDUALS. GLOBALLY, APPROXIMATELY 17 MILLION PEOPLE HAVE CP. IT IS A DIAGNOSIS THAT INCLUDES A WIDE RANGE OF SYMPTOMS WITH HETEROGENEOUS ETIOLOGIES OF NEURAL AND CARDIOVASCULAR ORIGINS. A WIDE RANGE OF FUNCTIONAL DISORDERS TYPICALLY BECOME OBVIOUS IN CP DURING EARLY DEVELOPMENT. FOR EXAMPLE, THE MAJORITY OF CHILDREN CLASSIFIED AS GROSS MOTOR FUNCTIONAL CLASSIFICATION SCALE (GMFCS) LEVEL I ARE EXPECTED TO REACH THEIR MOTOR POTENTIAL BETWEEN 7-9 YEARS AND REMAIN STABLE AFTER THAT UNTIL AGE 21 WHERE THEY MAY DECLINE DUE TO PAIN, WEAKNESS AND STIFFNESS. WHILE MOVEMENTS SUCH AS STEPPING AND POSTURE ARE AMONGST THE MOST RECOGNIZABLE IMPAIRMENTS, ABSENCE OR ABNORMAL SENSATIONS, PERCEPTION, IMPAIRED COGNITION, COMMUNICATION SKILLS, EPILEPSY, SPASTICITY, POOR CONTROL OF FINE MOVEMENTS AND MARKED SECONDARY MUSCULOSKELETAL PROBLEMS CAN EMERGE WITH TIME. PRESENTLY, ALL AVAILABLE INTERVENTIONS ARE DESIGNED TO MINIMIZE THE SEVERITY OF SYMPTOMS RATHER THAN CORRECTING THE NEUROLOGICAL ETIOLOGY. TWO COMMONLY PREFERRED TREATMENTS, SELECTIVE DORSAL ROOT RHIZOTOMY AND REPETITIVE ADMINISTRATION OF BOTULINUM TOXIN A (BOTOX) DIRECTLY TARGET THE NEUROMUSCULAR SYSTEM TO COUNTER SPASTICITY. WHILE THESE TWO STRATEGIES MINIMIZE SOME OF THE DISRUPTIVE MOVEMENTS ASSOCIATED WITH SPASTICITY; THE LONG-TERM BENEFITS OF THESE INTERVENTIONS ARE LESS CLEAR AND BOTH CAUSE IRREVERSIBLE CHANGES TO THE NEUROMUSCULAR SYSTEM THAT MAY BE DETRIMENTAL TO FUTURE FUNCTION. IN THE PRESENT PROPOSAL WE HAVE MERGED IDEAS AND CONCEPTS DERIVED FROM BOTH RECENT CLINICAL OBSERVATIONS OF CP AND DECADES OF STUDIES OF SPINAL CORD INJURY TO ARRIVE AT A SUBJECT-SPECIFIC REHABILITATION STRATEGY DRIVEN BY ACTIVITY- BASED MECHANISMS DURING TRANSCUTANEOUS SPINAL NEUROMODULATION. THE OBJECTIVES OF OUR NEUROMODULATION PROCEDURES ARE TO AMPLIFY THE PLASTICITY OF THE NEUROMUSCULAR SYSTEM AND HELP CHILDREN GAIN THE ABILITY TO PERFORM COORDINATED MOVEMENTS THROUGH ACTIVITY-DEPENDENT PLASTICITY. WE HYPOTHESIZED THAT TRANSCUTANEOUS SPINAL NEUROMODULATION DURING ACTIVITY-BASED NEUROREHABILITATION THERAPY (ABNT) CAN TRANSFORM THE NEURAL NETWORKS IN CHILDREN DIAGNOSED WITH SPASTIC CP TO IMPROVE VOLUNTARY POSTURAL AND LOCOMOTOR ACTIVITY AS CAPTURED ON THE GMFM88 SCORES. THIS STRATEGY COULD PROVIDE A SPECIFIC PHYSIOLOGICAL TARGET OF FUNDAMENTAL SIGNIFICANCE IN THE CONTROL OF MOVEMENT THAT CAN BE USED TO IMPROVE FUNCTION AND PROVIDE NEW CARE PATHWAYS FOR CHILDREN WITH CP.

THIS EDA INVESTMENT SUPPORTS THE TOWN OF SPINDALE WITH MAKING WATER AND SEWER SYSTEM IMPROVEMENTS NEEDED TO HELP BUSINESS GROWTH AND JOB CREATION IN RUTHERFORD COUNTY, NORTH CAROLINA. THE PROJECT WILL PROVIDE WATER AND SEWER SYSTEM UPGRADES NEEDED TO SUPPORT THE EXPANSION OF A LOCAL TRUCKLOAD CARRIER COMPANY, WHILE ATTRACTING OTHER BUSINESSES TO THE REGION, INCLUDING A TRAVEL PLAZA. ONCE COMPLETED, THE PROJECT WILL HELP IMPROVE EXISTING SUPPLY CHAIN ISSUES IN AN AREA IMPACTED BY FLUCTUATIONS IN THE ENERGY ECONOMY, WHICH WILL PROMOTE ECONOMIC GROWTH AND RESILIENCY THROUGHOUT THE REGION.

AUTOMATIC QUANTIFICATION AND LABELING OF CEREBRAL MICROBLEEDS, OXYGEN SATURATION AND SOURCES OF ABNORMAL SUSCEPTIBILITY

SUPPORTIVE HOUSING FOR PERSONS WITH DISABILITIES

KY-SPIN PARENT TRAINING AND INFORMATION CENTER PTI FOR THE STATE OF KENTUCKY

ADJUSTABLE HELMET ARRAY FOR NEONATAL MAGNETOENCEPHALOGRAPHY

VALIDATION OF ADVANCED URINARY PROSTHESIS FOR IMPROVED UROLOGIC MANAGEMENT AND OUTCOMES OF URINARY RETENTION DISORDERS

NON-PFSA MEMBRANES FROM SULFONATED POLYPHENYLENE COMPOSITES FOR ELECTROLYZERS AND FUEL CELLS

PARENT TRAINING AND INFORMATION CENTER

REVERSING ISONIAZID RESISTANCE BY ISOTOPIC SUBSTITUTION

MONODISPERSED MAGNETIC NANOPARTICLES FOR IMPROVED DIAGNOSTIC IMAGING. PHASE II: S

FETAL MAGNETOCARDIOGRAPHY USING NON-CRYOGENIC MAGNETIC FIELD SENSORS

PARENT TRAINING AND INFORMATION CENTER

GAAS PHOTOMULTIPLIER CHIP(TM) FOR TOF-PET

SBIR PHASE II: HIGH-YIELD PLATFORM PROCESS FOR FABRICATION OF UNIQUE NANOFIBER MATERIALS -THE BROADER IMPACT OF THIS SMALL BUSINESS INNOVATION RESEARCH (SBIR) PHASE II PROJECT ADDRESSES THE NEED FOR SCALABLE NANOFIBER MANUFACTURING THROUGH THE DEVELOPMENT AND REFINEMENT OF A PRODUCTION METHOD CAPABLE OF ACHIEVING OUTPUTS OF UTILITARIAN SPECIES OF NANOFIBERS IN QUANTITIES SUFFICIENT TO SERVE INDUSTRIAL APPLICATIONS. THIS PROJECT WILL CREATE NEW OPPORTUNITIES FOR NANOFIBER INTEGRATION INTO A WIDE VARIETY OF APPLICATIONS AS THE TECHNOLOGY WILL ENABLE THE COST-EFFICIENT PRODUCTION OF NANOFIBERS AT COMMERCIALLY ACCEPTABLE RATES, AND THE DEVELOPMENT OF UNIQUE NANOFIBER MATERIALS WITH PROPERTIES COMPATIBLE WITH SPECIFIC INDUSTRY USES. THIS NOVEL SYSTEM CAN PRODUCE A WIDE VARIETY OF ORGANIC, INORGANIC, AND POLYMER FIBER COMPOSITIONS ON DEMAND TO CREATE A VARIETY OF MATERIALS FOR NUMEROUS INDUSTRIES, INCLUDING WATER FILTRATION, AIR TREATMENT, THERMAL INSULATION, WOUND DRESSING, TISSUE ENGINEERING, CELL SCAFFOLDING, TEXTILES, AND BATTERY ENERGY STORAGE. THIS SMALL BUSINESS INNOVATION RESEARCH (SBIR) PHASE II PROJECT WILL DEVELOP A PLATFORM PROCESS TO MANUFACTURE CUSTOM NANOFIBERS USING ALTERNATING CURRENT ELECTROSPINNING, A SCALABLE AND COST-EFFICIENT METHOD THAT SUPPORTS OUTPUT EFFICIENCIES THOUSANDS OF TIMES HIGHER THAN STANDARD DIRECT CURRENT ELECTROSPINNING METHODS WHILE ALLOWING EASIER HANDLING OF THE FIBERS. THE ALTERNATIVE CURRENT ELECTROSPINNING METHOD CAN BE EMPLOYED TO PRODUCE UNIQUE NANOFIBERS IN QUANTITIES SUFFICIENT TO SERVE INDUSTRIAL APPLICATIONS. PHASE II WORK SEEKS TO FURTHER DEVELOP AND REFINE THE NANOFIBER PRODUCTION PLATFORM FOCUSING ON THE CONTROL AND CHARACTERIZATION OF NANOFIBER COMPOSITION AND ASSOCIATED MATERIAL PROPERTIES WHICH WILL INFORM THE DEVELOPMENT AND VALIDATION OF APPLICATION-SPECIFIC NANOFIBERS IN KEY MARKET ENTRY POINTS. IN OBJECTIVE 1, AN EXPANDED PORTFOLIO OF ALTERNATIVE CURRENT ELECTROSPINNING-PRODUCED NANOFIBERS WILL BE PURSUED BY DEVELOPING A CLASS OF ALUMINA NANOFIBERS. IN OBJECTIVE 2, PROCESS SCALEUP WILL BE EXPLORED TO ACHIEVE COMMERCIALLY RELEVANT YIELDS. NANOFIBERS WILL BE TESTED FOR TENSILE STRENGTH, ELASTIC MODULUS, PERMEABILITY, AND FLEXURAL MODULUS. OBJECTIVE 3 WILL FOCUS ON DEVELOPING AND VALIDATING APPLICATION-TAILORED NANOFIBERS FOR DELIVERY OF HIGH-PERFORMANCE PROPERTIES IN KEY MARKET ENTRY POINTS, INCLUDING WATER FILTRATION AND HYALURONIC ACID APPLICATIONS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

PROJECT TO FUND YESHIVA GEDOLAH IMREI YOSEF D'SPINKA TO PROVIDE EMERGENCY FINANCIAL AID GRANTS TO STUDENTS WHOSE LIVES HAVE BEEN DISRUPTED DUE FROM COVID 19 PANDEMIC

A 13 WEEK GLP TOXICOLOGY STUDY WITH SPG302 IN BEAGLE DOGS

PROJECT TO FUND YESHIVA GEDOLAH IMREI YOSEF D'SPINKA TO PROVIDE EMERGENCY FINANCIAL AID GRANTS TO STUDENTS WHOSE LIVES HAVE BEEN DISRUPTED DUE FROM COVID 19 PANDEMIC

CONTINUUM OF CARE PROGRAM

PHASE 2 STUDY OF THE HEMIBRIDGE SYSTEM FOR THE TREATMENT OF IDIOPATHIC SCOLIOSIS

STTR PHASE II: INTRAVENTRICULAR COOLING CATHETER

SPINDLETOP CENTER MHMR AND ORANGE COUNTY SEEK TO COLLABORATIVELY ADDRESSING THE NEEDS OF INDIVIDUALS EXPERIENCING SYMPTOMS OF MENTAL ILLNESS AND/OR SUBSTANCE USE DISORDERS. LAW ENFORCEMENT, JAIL ADMINISTRATION, THE JUDICIAL SYSTEM, THE LOCAL MENTAL HEALTH AUTHORITY, AND OTHER COMMUNITY ORGANIZATIONS WILL WORK WITH THESE INDIVIDUALS WITH MENTAL ILLNESS TO ENSURE EFFICIENT AND APPROPRIATE LINKAGE OF MENTAL HEALTH/SUBSTANCE ABUSE SERVICES.

SPECIAL EDUCATION-TRAINING AND INFORMATION FOR PARENTS OF CHILDREN WITH DISABILITIES - PARENT TRAINING AND INFORMATION CENTER

SMA EDUCATION AND OUTREACH IN THE NORTHEAST

SBIR PHASE II: STRUCTURES FOR REDUCED CRITICAL CURRENT TO ENABLE SPIN TORQUE MAGNETORESISTIVE RANDOM ACCESS MEMORY

A WEARABLE MAGNETOCARDIOGRAPHY IMAGING SYSTEM - PROJECT SUMMARY RECENT STUDIES HAVE SHOWN RADIATION THERAPY (RT) ABLATION TO BE A HIGHLY PROMISING ALTERNATIVE THERAPY FOR PATIENTS WITH DRUG-REFRACTORY VT WHO ARE UNABLE TO UNDERGO CATHETER-BASED ABLATION. IDEALLY, RT ABLATION IS PERFORMED IN CONJUNCTION WITH NONINVASIVE ELECTROPHYSIOLOGY (EP) IMAGING, SUCH AS ECG IMAGING (ECGI), SO THAT THE ENTIRE PROCEDURE IS NONINVASIVE; HOWEVER, CURRENTLY NONINVASIVE EP IMAGING IS MUCH LESS ACCURATE THAN RT AND NEEDS TO BE SIGNIFICANTLY IMPROVED TO REALIZE THE FULL POTENTIAL OF RT ABLATION. IN THIS PROJECT, WE PROPOSE TO UTILIZE MAGNETOCARDIOGRAPHY (MCG) TO DEVELOP AN MCG IMAGING (MCGI) SYSTEM. IN COMPARISON TO ECG, MCG PROVIDES FUNDAMENTAL ADVANTAGES FOR SOURCE LOCALIZATION AND IMAGING DUE TO THE FAVORABLE TRANSMISSION PROPERTIES OF MAGNETIC SIGNALS. FROM A PRACTICAL STANDPOINT, MCG IS MORE CONVENIENT BECAUSE IT IS A CONTACTLESS TECHNIQUE, WHEREAS ECGI REQUIRES APPLICATION OF A LARGE ARRAY OF ELECTRODES. THE PROPOSED SYSTEM WILL BE BASED ON A REVOLUTIONARY TYPE OF MAGNETIC SENSOR, KNOWN AS AN OPTICALLY-PUMPED MAGNETOMETER (OPM), WHICH WAS FIRST BROUGHT TO MARKET BY OUR COMPANY. OPMS ARE FAR MORE PRACTICAL THAN SQUID MAGNETOMETERS BECAUSE THEY ARE SMALLER, LESS EXPENSIVE, AND OPERATE AT ROOM TEMPERATURE. THIS WILL ENABLE CONSTRUCTION OF AN MCGI SYSTEM WITH A CONFORMAL SENSOR ARRAY THAT COVERS THE ENTIRE TORSO. THE OVERALL GOAL IS TO CONSTRUCT AN MCGI SYSTEM WITH IMPROVED ACCURACY AND EASE-OF-USE, COMPARED TO CURRENT ECGI/MCGI SYSTEMS. THE PHASE I AIMS ARE TO 1) DETERMINE AN OPTIMAL SENSOR CONFIGURATION FOR THE MCGI SYSTEM BASED ON ANALYSIS OF THE SPATIAL PROPERTIES OF THE SIGNAL, 2) DESIGN A COMPACT MAGNETIC SHIELD THAT IS PATIENT-FRIENDLY AND MINIMIZES THE SPACE REQUIREMENTS OF THE SYSTEM, 3) DEVISE A STRATEGY FOR RAPID, ACCURATE DIGITIZATION OF THE SENSOR LOCATIONS, AND 4) DEMONSTRATE THE FEASIBILITY OF KEY ASPECTS OF THE PROPOSED TECHNIQUES IN A SMALL STUDY OF NORMAL SUBJECTS.

NATIONAL FOLIC ACID PROGRAM

SMA EDUCATION AND OUTREACH IN THE NORTHEAST

2/2-PREVENTING PERINATAL DEPRESSION (PRE-D): DEVELOPING TOOLS AND INTERVENTIONS

KY-SPIN PARENT TRAINING AND INFORMATION (PTI) CENTER FOR THE STATE OF KENTUCKY

NOVEL SMALL MOLECULES THAT TARGET ALZHEIMER'S DISEASE BY INCREASING SPINOGENESIS AND DECREASING A-BETA TOXICITY

FREE-BREATHING DYNAMIC CARDIOPULMONARY FUNCTION IMAGING SYSTEM TO USE WITH XENON MRI - ABSTRACT THIS PROJECT SEEKS TO BUILD, QUALIFY AND EVALUATE CLINICAL FEASIBILITY OF A NOVEL CARDIOPULMONARY IMAGING DEVICE FOR CONTINUOUS ADMINISTRATION OF THE GASEOUS MAGNETIC RESONANCE IMAGING CONTRAST AGENT HYPERPOLARIZED XENON-129 (HPX), RECENTLY APPROVED BY THE FDA. PAIRED WITH A CLINICALLY PRACTICAL SET OF PHYSIOLOGICAL MONITORING MEASUREMENTS, WE INTEND THIS DEVELOPMENT TO SUPPORT A NEW PARADIGM FOR FUNCTIONAL LUNG IMAGING THAT IS ACCESSIBLE TO ALL PATIENTS REGARDLESS OF AGE OR DISEASE STATE, REMOVES SOURCES OF IRREPRODUCIBILITY AND BIAS ASSOCIATED WITH IMAGES ACQUIRED DURING EXTENDED BREATH-HOLD, AND OFFERS NEW OPPORTUNITIES FOR CONTRAST ASSOCIATED WITH THE DYNAMIC ASPECTS OF GAS- AND BLOOD-FLOW IN AN ORGAN THAT DURING NORMAL FUNCTIONING IS ALWAYS IN MOTION. WE PURSUE THIS GOAL BY FIRST DESIGNING AND BUILDING AN AUTOMATIC, MRI-COMPATIBLE, PISTON-BASED SET OF SYRINGE PUMPS THAT RESPOND TO SUBJECT BREATHING DYNAMICS BY INJECTING SUPPLEMENTAL HPX OR OXYGEN (OR ANY OTHER DESIRED AGENT) INTO THE INHALED GAS STREAM. BASED ON AN EXISTING PRODUCT USED FOR HPX IN VENTILATED SMALL-ANIMAL STUDIES, THIS DEVICE WILL ACCUMULATE AND RESPOND TO PASSIVELY-OBTAINED PNEUMOTACH MEASURES OF AIRFLOW, ALLOWING BOLUS OR CONSTANT- CONCENTRATION DELIVERY AS DESIRED, AS WELL AS SYNCHRONIZATION WITH THE MR IMAGING DATA, THE HEARTBEAT, AND EXHALED GAS CONCENTRATIONS, WITHOUT THE NEED FOR PATIENT COMPLIANCE WITH BREATHING MANEUVERS. THE COMBINED DATASET WILL SUPPORT IDENTIFICATION OF ABNORMAL VENTILATION, PERFUSION OR GAS DIFFUSION DURING PHYSIOLOGICALLY RELEVANT CONDITIONS. SUBSEQUENTLY SYNCHRONOUS MONITORING AND CAPTURING OF INHALED AND EXHALED O2, CO2 AND XENON CONCENTRATIONS IS INCORPORATED THROUGHOUT THE BREATHING CYCLE. THIS PROJECT ALSO AIMS TO DEMONSTRATE FEASIBILITY OF THE DYNAMIC LUNG HPX MRI IN A SMALL PILOT STUDY. IDENTIFYING KEY DESIGN ISSUES, EVALUATING PATIENT TOLERANCE AND COLLECTING PRELIMINARY FEEDBACK FROM CLINICAL SUPPORT STAFF ARE ESSENTIAL AT THIS DESIGN STAGE IN ORDER TO INFORM KEY DEVICE VALIDATION ACTIVITIES IN PHASE II INCLUDING DEVICE VALIDATION AND HUMAN FACTORS.

STTR PHASE I: HIGH-YIELD PLATFORM PROCESS FOR FABRICATION OF UNIQUE NANOFIBER MATERIALS

SBIR PHASE I: DEVELOPMENT OF TRANSCUTANEOUS ELECTRICAL SPINAL CORD NEUROMODULATOR FOR HOME USE

X-RAY VISUALIZED INTERBODY SPACER INDICATING BIOMECHANICAL LOAD (X-VISIBL) FUSION DEVICE - ABSTRACT SPINE DISORDERS, PRIMARILY CAUSED BY DEGENERATIVE SPINE CONDITIONS, DEFORMITY, TUMORS, AND TRAUMA, AFFECT APPROXIMATELY HALF OF THE POPULATION AGED OVER 40. TO ADDRESS THESE DISORDERS, OVER 457,000 SPINE FUSIONS WERE PERFORMED IN THE US IN 2011 (6% ANNUAL GROWTH), INCLUDING ABOUT 290,000 ANTERIOR CERVICAL DISCECTOMY AND FUSIONS (ACDF). ACDF SURGERY REMOVES 1-4 INTERVERTEBRAL DISCS AND REPLACES THEM WITH INTERBODY SPACERS FILLED WITH BONE GRAFT. THIS DISTRACTS AND DECOMPRESS THE NERVE ROOTS WHILE FUSING THE ADJACENT VERTEBRAE. POSTOPERATIVELY, IT IS CRITICAL TO RECOGNIZE WHEN THE VERTEBRAE HAVE FUSED, AN OUTCOME THAT DETERMINES SAFE RETURN TO ACTIVITY; CONVERSELY, DELAYED FUSION MAY INDICATE NEED FOR ADDITIONAL INTERVENTIONS (E.G., PROLONGED COLLAR USAGE, MODIFIED PHYSICAL THERAPY, ELECTRICAL STIMULATION, AND INJECTIONS SUCH AS RHPTH). IMPROPER MANAGEMENT CAN LEAD TO POOR OUTCOMES, WORSE PAIN, SURGICAL REVISION AND NEUROLOGICAL DEFICITS. UNFORTUNATELY, PATIENTS HEAL AT RATES THAT VARY GREATLY, AND SOME PATIENTS WILL NOT HEAL PROPERLY WITH 7% NEEDING COSTLY REVISION SURGERY ($123,000 HOSPITAL CHARGES). WE PROPOSE TO DEVELOP AN X-RAY VISIBLE INTERBODY SPACER INDICATING BIOMECHANICAL LOAD (X-VISIBL) FUSION DEVICE TO ASSIST CLINICIANS IN TRACKING AND DETECTING BONY FUSION. IF SUCCESSFUL, THIS PROJECT WILL VALIDATE A SIMPLE INDICATOR THAT REPORTS LOAD ON THE DEVICE TO ASSESS FUSION OF THE ADJACENT BONES. MEASUREMENTS ARE MADE USING FLEXION/EXTENSION RADIOGRAPHY WHICH IS ALREADY ROUTINELY USED IN PATIENT FOLLOW-UP BUT IS CURRENTLY INSUFFICIENTLY SENSITIVE TO DETECT DELAYED FUSION AND NON-UNION. MONITORING IMPLANT LOAD WILL PROVIDE THE PATIENT AND MEDICAL TEAM CRITICAL INFORMATION TO SELECT EARLY TARGETED INTERVENTIONS INCLUDING PROLONGED BRACE OR COLLAR USAGE, MODIFIED PHYSICAL THERAPY AND RETURN-TO-WORK PROTOCOLS, ULTRASOUND OR ELECTRICAL STIMULATION, MEDICATIONS OR INJECTIONS SUCH AS RHPTH, AND INFORM LONG TERM CARE TO AVOID DEVICE FAILURE AND ASSOCIATED PAIN, DISABILITY AND REOPERATIONS. THIS PHASE I SMALL BUSINESS TECHNOLOGY TRANSFER PROJECT AIMS TO ASSESS TECHNICAL FEASIBILITY FOR A LOAD INDICATING CERVICAL INTERBODY SPACER. THE APPROACH IS INNOVATIVE IN PROVIDING A SENSOR TO CLEARLY MEASURE LOAD DURING FUSION WITH X-RAY READOUT THAT IS ALREADY PART OF THE STANDARD OF CARE. TO SHOW FEASIBILITY, WE MUST DEVELOP PROTOTYPES WITH MECHANICAL PROPERTIES THAT ALLOW/ENCOURAGE FUSION (ESPECIALLY STIFFNESS AND YIELD) AND THE PRECISION TO DETECT PHYSIOLOGICAL LOAD CHANGES DURING FUSION. THIS WILL BE ACCOMPLISHED WITH COMPUTER SIMULATIONS, MECHANICAL PROTOTYPE FABRICATION AND TESTING, AND RADIOGRAPHY IN CADAVERIC MODELS. THE RESEARCH IS RELEVANT TO PUBLIC HEALTH BECAUSE, IT PROVIDES AN OBJECTIVE NON-INVASIVE MEANS TO ASSESS BIOMECHANICAL FUSION AND ASSIST PHYSICIANS PRESCRIBING REHABILITATION PROTOCOLS AND ADJUNCTIVE THERAPIES.

THE FY25 COPS HIRING PROGRAM (CHP) PROVIDES FUNDING TO LAW ENFORCEMENT AGENCIES TO HIRE AND/OR REHIRE ADDITIONAL CAREER LAW ENFORCEMENT OFFICERS IN AN EFFORT TO INCREASE THEIR COMMUNITY POLICING CAPACITY AND CRIME PREVENTION EFFORTS. ANTICIPATED OUTCOMES OF CHP AWARDS INCLUDE ENGAGEMENT IN PLANNED COMMUNITY PARTNERSHIPS, IMPLEMENTATION OF PROJECTS TO ANALYZE AND ASSESS PROBLEMS, IMPLEMENTATION OF CHANGES TO PERSONNEL AND AGENCY MANAGEMENT IN SUPPORT OF COMMUNITY POLICING, AND INCREASED CAPACITY OF AGENCY TO ENGAGE IN COMMUNITY POLICING ACTIVITIES

PET DETECTOR

A NOVEL COMBINATORIAL APPROACH FOR TREATING HPV-ASSOCIATED MALIGNANCIES

SBIR PHASE I: NOVEL METHOD TO QUANTITATIVELY ASSESS SPINAL ALIGNMENT INTRAOPERATIVELY WITH REDUCED RELIANCE ON RADIATION-BASED IMAGING

SBIR PHASE I: HISTOMAPR-BREAST: COMPUTATIONAL DIAGNOSTIC GUIDES FOR BREAST PATHOLOGIES

ADVANCED URINARY CATHETER FOR REDUCTION OF URINARY TRACT INFECTIONS AND IMPROVED UROLOGIC MANAGEMENT

SUSTAINED RELEASE STEROID TO REDUCE FREQUENT EPIDURAL INJECTIONS FOR BACK PAIN

SBIR PHASE I: IMPROVING BEHAVIORAL ASSESSMENT OF CHILDREN DIAGNOSED WITH AUTISM SPECTRUM DISORDER THROUGH ENHANCED DATA ACQUISITION

MONODISPERSED BIOCOMPATIBLE MAGNETIC NANOPROBES FOR IMPROVED DIAGNOSTIC IMAGING

HOMELESS ASSISTANCE

NANOFIBER WIPES FOR DECONTAMINATION OF EQUIPMENT/STRUCTURES

NANOSTRUCTURED PROTON EXCHANGE MEMBRANE

RIFAMPIN POTENTIATION IN NTM

PHOTOMULTIPLIER CHIP(TM) FOR ULTRA-FAST TOF-PET

ADJUSTABLE HELMET ARRAY FOR NEONATAL MAGNETOENCEPHALOGRAPHY

FETAL MAGNETOCARDIOGRAPHY USING NON-CRYOGENIC MAGNETIC FIELD SENSORS

STAFFING FOR ADEQUATE FIRE AND EMERGENCY RESPONSE (SAFER)

PROJECT TO FUND YESHIVA GEDOLAH IMREI YOSEF D'SPINKA TO PROVIDE FINANCIAL AID TO STUDENTS THAT SUFFER FINANCIALLY AS A RESULT OF THE COVID 19 PANDEMIC.

SIPM ARRAY DETECTOR FOR 50 PS CTR

MANUFACTURE OF SELF-REPORTING, DRUG LOADED POROUS SILICON NANOMATERIALS FOR TREAT

RADIATION HARD GAINP PHOTOMULTIPLIER CHIP (TM)

SBIR PHASE I: LASER-ENHANCED HYPERSENSITIVE BENCH-TOP NMR SYSTEM

STTR PHASE I: NANOFIBER BASED LITHIUM ION BATTERY SEPARATOR WITH REVERSIBLE THERMAL SHUTDOWN CAPABILITY

RADIATION-TOLERANT, HIGH-DENSITY GAINP SPAD ARRAYS

SBIR PHASE I: SURFACE MODIFICATION OF NONWOVENS VIA PLASMA PROCESSING

SBIR PHASE I: BIOCOMPATIBLE TRACERS OPTIMIZED FOR MAGNETIC PARTICLE IMAGING

RADIATION HARD TIGHT PITCH GAINP SPAD ARRAYS FOR HIGH ENERGY PHYSICS

SBIR PHASE I: STRUCTURES FOR REDUCED CRITICAL CURRENT TO ENABLE SPIN TORQUE MRAM

OVERCOMING ISONIAZID RESISTANCE IN TUBERCULOSIS WITH NEW CHEMICAL ENTITITES

STTR PHASE I: INTRAVENTRICULAR COOLING CATHETER

ASSISTANCE TO FIREFIGHTERS GRANT

CONTINUUM OF CARE PROGRAM

RURAL HOUSING PRESERVATION GRANTS

ASSISTANCE TO FIREFIGHTERS GRANTS

REAP RENEWABLE ENERGY SYSTEM (RES) GRANT UNRESTRICTED AMOUNT - IRA 24/31

ASSISTANCE TO FIREFIGHTERS GRANT

CONTINUUM OF CARE PROGRAM

FIRST WORLD CONGRESS ON SPINA BIFIDA RESEARCH AND CARE

RURAL BUSINESS ENTERPRISE GRANTS

REAP RENEWABLE ENERGY SYSTEM (RES) GRANT UNRESTRICTED AMOUNT

ASSISTANCE TO FIREFIGHTERS GRANT

ASPINWALL S NURSERY AND PRODUCE - PANDEMIC RESPONSE AND SAFETY GRANTS PROGRAM APPLICATION

ASSISTANCE TO FIREFIGHTERS GRANT

THIS GRANT SUPPORTS THE COSTS INCURRED TO IMPLEMENT MEASURES TO RESPOND TO THE NOVEL CORONAVIRUS 2019 (COVID-19), WHICH MAY INCLUDE WORKPLACE SAFETY, MARKET PIVOTS, RETROFITTING FACILITIES, TRANSPORTATION, WORKER HOUSING, AND MEDICAL EXPENSES. IT PROVIDES NEEDED RELIEF TO THE FOOD PROCESSORS, DISTRIBUTORS, FARMERS MARKETS, AND PRODUCERS FOR THEIR COSTS INCURRED BETWEEN JANUARY 27, 2020, THE DATE UPON WHICH THE PUBLIC HEALTH EMERGENCY WAS DECLARED BY THE U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICE (HHS) UNDER SECTION 319 OF THE PUBLIC HEALTH SERVICE ACT, AND DECEMBER 31, 2021. BENEFICIARIES INCLUDE THE EMPLOYEES OF THE FOOD PROCESSORS, DISTRIBUTORS, FARMERS MARKETS, AND PRODUCERS.

PURPOSE: TO SUPPORT THE WORLD PREMIERE PRODUCTION OF A PLAY ABOUT YOUTH WITH AUTISM.

SEC 9007 REAP-RENEW ENERGY SYSTEMS GRANTS, $20,000 OR LESS (MAN)

FIRST WORLD CONGRESS ON SPINA BIFIDA RESEARCH AND CARE

PURPOSE: TO SUPPORT A PRODUCTION OF THE COUNTRY OF THE BLIND BY FRANK HIGGINS AND RELATED ACTIVITIES. 

ASSISTANCE TO FIREFIGHTERS GRANT

SEC 9007 REAP-RENEW ENERGY EFFICIENCY IMPROVE GRANTS, $20,000 OR LESS (MAN)

SEC. 9007 REAP-ENERGY EFFICIENCY IMPROVEMENTS GRANTS (MAN)

PLANT MATERIALS CENTER

PLANT MATERIALS CENTER

ASSISTANCE TO FIREFIGHTERS GRANT

2010 TECHNICAL ASSISTANCE GRANTS

REAP RENEWABLE ENERGY SYSTEM (RES) GRANT UNRESTRICTED AMOUNT

ASSISTANCE TO FIREFIGHTERS GRANT