Seton Hall University

SETON HALL UNIVERSITY HIGHER EDUCATION EMERGENCY RELIEF FUND2

SETON HALL UNIVERSITY CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND

FINE MAPPING SUSCEPTIBILITY LOCI FOR NICOTINE DEPENDENCE

NURSE EDUCATION, PRACTICE, QUALITY AND RETENTION

UPWARD BOUND PROGRAM AT SETON HALL UNIVERSITY

UPWARD BOUND PROGRAM

UPWARD BOUND

MECHANISMS OF NICOTINE'S BEHAVIORAL EFFECTS ON THE HIV-1 TRANSGENIC RAT

IMMUNOMODULATION OF NICOTINE IN HIV-1TG RAT BRAIN

METHYLATION IN BINGE ETHANOL-INDUCED SPLEEN ATROPHY IN ADOLESCENT RATS

STUDENT SUPPORT SERVICES PROGRAM

WRITING IN STUDENTS WITH LANGUAGE-BASED LEARNING DISABILITIES (WILLD)

STUDENT SUPPORT SERVICES PROGRAM AT SETON HALL UNIVERSITY

PROJECT WRITE TO LEARN: PREPARATION OF OCCUPATIONAL THERAPISTS AND SPEECH LANGUAGE PATHOLOGISTS TO IMPROVE WRITTEN EXPRESSION IN CHILDREN WITH SPECIFIC LEARNING DISABILITIES

MORPHINE ACTIONS ON THE IMMUNE SYSTEM

COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - CONSTRUCTION

TRIO - STUDENT SUPPORT SERVICES - STUDENT SUPPORT SERVICES PROGRAM

ALCOHOL'S EFFECTS ON THE ADOLESCENT: CORRELATION BETWEEN THE DOPAMINERGIC SYSTEM

PURPOSE:THE PURPOSE OF THIS GRANT IS TO ENHANCE RESEARCH CAPABILITIES AT THE ADVANCED MATERIALS SYNTHESIS AND CHARACTERIZATION LABORATORY (AMSCL) AT SETON HALL UNIVERSITY TO ENABLE RESEARCH ON LOW-TEMPERATURE PLASMAS (LTPS) THAT ARE USED IN ADVANCED MANUFACTURING. THIS EQUIPMENT WILL PROVIDE INDEPENDENT CONTROL, VARIATION, AND OPTIMIZATION OF NEUTRAL, ION, ELECTRON, AND PHOTON FLUXES WITHIN LTPS INTERACTING WITH SURFACES OF EMERGING SEMICONDUCTORS MATERIALS AND OTHER ADVANCED FUNCTIONAL MATERIALS. THESE ENHANCED CAPABILITIES WILL PROVIDE OPPORTUNITIES FOR STUDENTS TO GAIN DIRECT EXPERIENCE WITH ADVANCED ENGINEERING EQUIPMENT AND SERVE AS A PLATFORM TO DEVELOP TARGETED CURRICULA.ACTIVITIES TO BE PERFORMED:THE RESEARCHERS WILL UTILIZE THESE FACILITIES TO INVESTIGATE PROBLEMS IN SEVERAL AREAS INCLUDING NEW MATERIALS FOR SEMICONDUCTOR DEVICES AND PROCESSING AND PHOTOVOLTAIC CELLS. SPECIFICALLY, THE AMSCL WILL BE ABLE TO SYNTHESIZE THIN FILMS OF MATERIALS THROUGH PULSED-LASER DEPOSITION THAT CAN BE CHARACTERIZED AT ADVANCED FACILITIES SUCH AS THE NSLS-II SYNCHROTRON-BASED X-RAY ABSORPTION SPECTROSCOPY AT BROOKHAVEN NATIONAL LAB. AND, INVESTIGATIONS OF THE CORRELATION OF THIN FILM GROWTH, STRUCTURE, AND ELECTRICAL PROPERTIES OF PHOTOVOLTAIC THIN FILMS AND MATERIALS BASED UPON CDTE AND CIGS, CANDIDATES FOR NEXT-GENERATION PHOTOVOLTAIC THIN FILMS.EXPECTED OUTCOMES:THE INCREASED CAPABILITIES WILL EXPAND THE RANGE OF RESEARCH POSSIBLE AT THE UNIVERSITY AND ENHANCE THE RANGE OF MATERIALS THAT CAN BE INVESTIGATED AT EXTERNAL RESEARCH SITES SUCH AS BROOKHAVEN NATIONAL LABORATORY. A NUMBER OF MATERIALS SYSTEMS WILL BE AVAILABLE TO STUDY INCLUDING HF-BASED DIELECTRICS THAT ARE NEEDED IN ADVANCED TRANSISTORS, GLASS PHOTONIC FILMS BASED UPON NB, CDTE, CIGS, AND MATERIALS MODIFIED BY DIELECTRIC BARRIER DISCHARGE TECHNIQUES. THE RESEARCH OUTPUT FROM THE FACILITY IN THE FORM OR PEER-REVIEWED PAPERS AND PRESENTATIONS WILL INCREASE.INTENDED BENEFICIARIES:STUDENTS, BOTH UNDERGRADUATE AND GRADUATE LEVELS, WILL BE THE PRIMARY BENEFICIARIES OF THE ENHANCED FACILITIES WHERE ADVANCED RESEARCH CAN BE PERFORMED. STUDENTS WOULD ALSO BENEFIT FROM THE DIRECT EXPERIENTIAL LEARNING THE FUNDAMENTALS OF PLASMA PROCESSING, A TECHNIQUE WIDELY USED IN THE SEMICONDUCTOR INDUSTRY. THESE FACILITIES WOULD BE UNAVAILABLE WITHOUT THIS SUPPORT.SUBRECIPIENT ACTIVITIES:THE RECIPIENT DOES NOT INTEND TO SUBAWARD FUNDS.

SETON HALL UNIVERSITY SCIENCE AND TEHCNOLOGY CENTER

PROJECT TRANSITIONS: AN INTERDISCIPLINARY TRAINING PROGRAM FOR OT AND SLP SCHOLARS TO SUPPORT TRANSITIONS FOR SCHOOL-AGE CHILDREN WITH AUTISM SPECTRUM DISORDER (ASD)

SETON HALL UNIVERSITY: SETON HALL LAW SCHOOL CENTER FOR SOCIAL JUSTICE COMMUNITY-BASED REENTRY AND SUPPORT SERVICES PROPOSAL ABSTRACT THE SETON HALL LAW SCHOOL CENTER FOR SOCIAL JUSTICE PROPOSES TO IMPLEMENT A REENTRY PROJECT THAT ADDRESSES THE NEEDS OF COMMUNITIES IMPACTED BY THE CRIMINAL LEGAL SYSTEM. THE PURPOSE IS TO HELP PEOPLE IN ESSEX COUNTY, NEW JERSEY ADDRESS LEGAL ISSUES RELATED TO THEIR ABILITY TO SECURE A JOB, HEALTH CARE, HOUSING, AND OTHER ESSENTIAL NEEDS UPON RETURN TO THE COMMUNITY AFTER INCARCERATION. MATERIALS WILL BE DEVELOPED, SUCH AS ONLINE TOOLS, TO HELP PEOPLE ASSESS THEIR LEGAL NEEDS AND PURSUE REMEDIES AVAILABLE TO THEM THAT FACILITATE REINTEGRATION. A KEY ASPECT OF THE PROPOSAL IS THE USE OF A MOBILE LEGAL LAB WITH LAPTOPS, PRINTERS, AND INTERNET ACCESS WHICH WILL BE AVAILABLE IN COMMUNITY CENTERS, IN HOUSES OF WORSHIP, OR AT OTHER PUBLIC GATHERING SPACES TO FACILITATE WORK IN THE COMMUNITY. IN ADDITION, PARTNERING WITH COMMUNITY AND GRASSROOTS ORGANIZATIONS, STUDENTS AND ATTORNEYS WITH THE CRIMINAL DEFENSE AND COMMUNITY ADVOCACY CLINIC WILL SUPPORT THE COMMUNITY IN DEVELOPING AN ACTIVE PARTICIPATORY DEFENSE PRACTICE. THE PROJECT FOCUSES ON DEVELOPING A STRUCTURE AND TOOLS TO SUPPORT THE BUILDING OF POWER WITHIN COMMUNITIES TO ADVOCATE INSIDE AND OUTSIDE THE CRIMINAL LEGAL SYSTEM, AND TO CREATE ENDURING AND TRANSFORMATIVE SOCIAL CHANGE ABOUT THE BROADER ISSUES THAT IMPACT COMMUNITY MEMBERS LIVES AND FUTURES. INITIAL RESEARCH WILL DETERMINE THE LEGAL AND SUPPORT SERVICES THAT WOULD HAVE THE MOST IMPACT. EXPECTED OUTCOMES INCLUDE THE DEVELOPMENT OF PARTICIPATORY DEFENSE HUBS IN NEWARK, NEW JERSEY AND THE PROVISION OF COMMUNITY EDUCATION AND LEGAL SERVICES RELATED TO REENTRY AND THE CRIMINAL LEGAL SYSTEM.

MORPHINE ACTIONS ON THE IMMUNE SYSTEM

DIRECTED GRANTS

EMERGENCY MANAGEMENT FOR HIGHER EDUCATION

CAREER: HUMAN ADAPTATIONS TO CHANGING ENVIRONMENTS: SUPPORTING STUDENT EDUCATION AND RESEARCH IN ANTHROPOLOGICAL ISOTOPIC METHODOLOGIES

EXPANDED INTERPROFESSIONAL MEDICATION-ASSISTED TREATMENT TRAINING PROGRAM - THIS PROJECT SEEKS TO INCREASE THE NUMBER OF NURSE PRACTITIONER (NP), PHYSICIAN ASSISTANT (PA), AND MEDICAL (MD) STUDENTS AT SETON HALL UNIVERSITY (SHU), HACKENSACK MERIDIAN SCHOOL OF MEDICINE (HMSOM), AND MONMOUTH UNIVERSITY (MU) COMPLETING THE DATA WAIVER REQUIRED TRAINING AND INCREASE THE NUMBER OF NPS, PAS AND PHYSICIANS DELIVERING MEDICATION-ASSISTED TREATMENT IN NJ BY PROVIDING AN APPROVED INTERPROFESSIONAL CURRICULUM AND TRAINING PROGRAM. THE PROJECT WILL ALSO ADDRESS HEALTH DISPARITIES AND SOCIAL DETERMINANTS OF HEALTH OF UNDERSERVED, VULNERABLE POPULATIONS, INCLUDING BLACKS LIVING IN URBAN COMMUNITIES WITH HIGH MORTALITY RATES DUE TO OVERDOSE, BY REVISING THE CURRICULUM AND PROVIDING CLINICALS AT SITES IN NEWARK, NJ INCLUDING INTEGRITY HOUSE, BROADWAY HOUSE, THE MENTAL HEALTH ASSOCIATION OF ESSEX AND MORRIS, INC., AND SAINT JAMES HEALTH. IN SUPPORT OF THESE GOALS, THE PROPOSED “EXPANDED INTERPROFESSIONAL MEDICATION-ASSISTED TREATMENT TRAINING PROGRAM” WILL SEEK TO ACHIEVE THE FOLLOWING OBJECTIVES BY: DECEMBER 2021, THE CURRICULUM BUNDLE, CONSISTING OF THE REQUIRED 24 HOURS OF DIDACTIC TRAINING MODULES FOR NP AND PA STUDENTS, WILL BE FULLY DEVELOPED; AND 160 HMSOM MD STUDENTS (COHORT 1) WILL HAVE COMPLETED THE REQUIRED DIDACTIC TRAINING; JANUARY 2022, THE REVISED CURRICULUM ADDRESSING HEALTH CARE DISPARITIES AND SOCIAL DETERMINANTS OF HEALTH AFFECTING UNDERSERVED AND VULNERABLE POPULATIONS WILL BE READY FOR IMPLEMENTATION INTO THE CURRICULUM; MAY 2022, 60 SHU PA STUDENTS (COHORT 1) WILL HAVE COMPLETED THE REQUIRED DIDACTIC TRAINING; AUGUST 2022, 70 SHU NP STUDENTS (COHORT 1) AND 10 MU NP STUDENTS (COHORT 1) WILL HAVE COMPLETED THE REQUIRED DIDACTIC TRAINING; DECEMBER 2022, 160 HMSOM MD STUDENTS (COHORT 2) AND 20 MU NP STUDENTS (COHORT 2) WILL HAVE COMPLETED THE DIDACTIC TRAINING; AND 10 MU NP STUDENTS (COHORT 1) WILL HAVE COMPLETED ALL CLINICAL TRAINING REQUIREMENTS; MAY 2023, 60 SHU PA STUDENTS (COHORT 2), 20 MU NP STUDENTS (COHORT 3), AND 30 MU PA STUDENTS (COHORT 1) WILL HAVE COMPLETED THE REQUIRED DIDACTIC TRAINING; AND 70 SHU NP STUDENTS (COHORT 1), 160 HMSOM MD STUDENTS (COHORT 1), 20 MU NP STUDENT (COHORT 2), AND 30 MU PA STUDENTS (COHORT 1) WILL HAVE COMPLETED ALL CLINICAL TRAINING REQUIREMENTS; AUGUST 2023, 70 SHU NP STUDENTS (COHORT 2) AND 10 MU NP STUDENTS (COHORT 4) WILL HAVE COMPLETED THE REQUIRED DIDACTIC TRAINING; DECEMBER 2023, 160 HMSOM MD STUDENTS (COHORT 3) AND 20 MU NP STUDENTS (COHORT 5) WILL HAVE COMPLETED THE DIDACTIC TRAINING; AND 60 SHU PA (COHORT 1), AND 30 MU NP STUDENTS (COHORTS 3 AND 4) WILL HAVE COMPLETED ALL CLINICAL TRAINING REQUIREMENTS; MAY 2024, 60 SHU PA STUDENTS (COHORT 3), 20 MU NP STUDENTS (COHORT 6), AND 30 MU PA STUDENTS (COHORT 2) WILL HAVE COMPLETED THE REQUIRED DIDACTIC TRAINING; AND 70 SHU NP STUDENTS (COHORT 2), 160 HMSOM MD STUDENTS (COHORT 2), 20 MU NP STUDENTS (COHORT 5), AND 30 MU PA STUDENTS (COHORT 2) WILL HAVE COMPLETED ALL CLINICAL TRAINING REQUIREMENTS; AND AUGUST 2024, 70 SHU NP STUDENTS (COHORT 3) AND 10 MU NP STUDENTS (COHORT 7) WILL HAVE COMPLETED THE REQUIRED DIDACTIC TRAINING.

SETON HALL UNIVERSITY AND HACKENSACK MERIDIAN HEALTH INTERPROFESSIONAL MEDICATION-ASSISTED TREATMENT TRAINING PROGRAM

INVOLVEMENT OF MICROGLIAL ?7ACHR IN BINGE ALCOHOL MODULATION OF GUT DYSBIOSIS - BINGE ALCOHOL DRINKING IS VERY COMMON AMONG THE YOUNG PEOPLE. EXCESSIVE ALCOHOL CONSUMPTION AFFECTS INNATE IMMUNE SIGNALING IN THE GUT AND THE BRAIN BY ALTERING GENE EXPRESSION AND MOLECULAR PATHWAYS WHICH LEAD TO ALCOHOL USE DISORDER (AUD). THE BINGE ALCOHOL-MODULATED GUT-BRAIN AXIS, RETROGRADELY, IS ASSOCIATED WITH NEUROINFLAMMATION AND MICROGLIAL ACTIVATION. ON THE OTHER HAND, BINGE ALCOHOL, ANTEROGRADELY, MAY CAUSE NEUROINFLAMMATION-MEDIATED GUT DYSBIOSIS, VIA THE “MICROGLIA-GUT AXIS”. TARGETING THE NEUROIMMUNE SYSTEM IS A NEW AVENUE FOR DEVELOPING AND REPURPOSING EFFECTIVE PHARMACOTHERAPIES AND IT IS CLINICALLY RELEVANT AND HIGHLY SIGNIFICANT. THE NICOTINIC ALPHA7 ACETYLCHOLINE RECEPTOR (7ACHR), WHICH IS EXPRESSED IN MICROGLIA REGULATES NEUROINFLAMMATION THROUGH CHOLINERGIC ANTI-INFLAMMATORY PATHWAY. OUR PUBLISHED DATA AND OTHER STUDY SHOWED THAT LIPOPOLYSACCHARIDE (LPS)-INDUCED INFLAMMATION RELEASES PRO-INFLAMMATORY CYTOKINES AND UPREGULATES NON- FUNCTIONAL 7ACHR (FUTILE) IN MACROPHAGES AND MICROGLIA. STIMULATION OF FUTILE 7ACHR WITH GTS-21 (7ACHR AGONIST), DECREASES LPS-INDUCED TNF RELEASE IN MACROPHAGES, AND KNOCKDOWN OF 7ACHR WITH 7ACHR SIRNA IN LPS-INDUCED MACROPHAGES ABOLISH GTS-21 BENEFICIAL EFFECTS. OUR PRELIMINARY STUDIES DEMONSTRATED THAT MICE GIVEN BINGE ETHANOL (ETOH) SUFFER WITH GUT DYSBIOSIS AND CONTINUOUSLY EXHIBIT SIGNIFICANT DIFFERENCES IN -DIVERSITY ALONG WITH AN INCREASE IN COMMENSAL PROPORTIONS OF PREVOTELLACEAE FAMILY. TAKEN THESE PREMISES TOGETHER, WE HYPOTHESIZE THAT BINGE ETOH EXPOSURE CAUSES NEUROINFLAMMATION AND GUT DYSBIOSIS DUE TO THE RELEASE OF PROINFLAMMATORY CYTOKINES, WHICH LEAD TO MICROGLIAL ACTIVATION AND INCREASED EXPRESSION OF MICROGLIAL 7ACHR (FUTILE), AND BIOINFORMATIC ANALYSIS OF THESE FACTORS COULD ESTABLISH A FUNCTIONAL RELATIONSHIP AMONG THEM. IN IN VIVO, DISRUPTION OF MICROGLIA AND MICROGLIAL 7ACHR UTILIZING PLX-5622 (MICROGLIA DEPLETION REAGENT) AND MICROGLIAL 7ACHR CONDITIONAL KNOCKOUT (7ACHRCKO) MICE, RESPECTIVELY, WILL ELUCIDATE THE DISCRETE ROLES OF MICROGLIA AND MICROGLIAL 7ACHR AFTER BINGE ETOH EXPOSURE. THE PHARMACOLOGICAL INTERVENTION OF GTS-21 IN VIVO WILL REVERSE ETOH-INDUCED EFFECTS ON MICROGLIA ACTIVATION, NEUROINFLAMMATION AND GUT DYSBIOSIS INVOLVING 7ACHR. TO TEST THESE HYPOTHESES, WE HAVE POSITED TWO SPECIFIC AIMS. AIM 1 IS TO CHARACTERIZE ACTIVATION OF MICROGLIA, NEUROINFLAMMATION AND GUT DYSBIOSIS FOLLOWING BINGE ETOH EXPOSURE USING C57BL/6J (B6) MICE AND BIOINFORMATICS TOOLS. AIM 2 IS TO ELUCIDATE THE INVOLVEMENT OF MICROGLIAL 7ACHR AND ROLE OF MICROGLIA IN ALCOHOL- MODULATION OF NEUROINFLAMMATION AND GUT DYSBIOSIS BY UTILIZING B6 AND 7ACHRCKO MICE USING PLX-5622 AND GTS-21. OUR INNOVATIVE PROJECT WITH HIGH CLINICAL RELEVANCE, MIGHT HAVE HIGH RISK, YET VERY LIKELY HIGH REWARD. SUCCESSFUL COMPLETION OF THIS R21 PROJECT SHALL SHIFT THE PARADIGM FROM OBSERVING THE GUT-BRAIN AXIS TO UNDERSTANDING AND PHARMACOLOGICALLY TARGETING THE MICROGLIA-GUT AXIS FOLLOWING BINGE EXPOSURE TO ETOH AND WOULD ALLOW US TO DEVELOP A FULL LENGTH R01 PROJECT TO TARGET THE NEUROIMMUNE SIGNALING IN DEVELOPING AND REPURPOSING EFFECTIVE PHARMACOTHERAPIES FOR ALCOHOL DRINKERS.

EFFECTS OF BINGE ETHANOL ON NEUROINFLAMMATION AND NEURODEGENERATION WITH HIGH FAT DIETS - ABSTRACT: OBESITY HAS BEEN ASSOCIATED WITH NEUROINFLAMMATION AND NEURODEGENERATION. BINGE DRINKING (BD) HAS ALSO BEEN REPORTED TO LEAD TO NEUROINFLAMMATION AND BRAIN ATROPHY. MOREOVER, OUR BIOINFORMATICS ANALYSIS USING INGENUITY PATHWAY ANALYSIS (IPA) LICENSED FROM QIAGEN CONFIRMED THAT ETHANOL (ETOH) AND OBESITY INDUCE NEUROINFLAMMATION. STUDIES HAVE SUGGESTED ALCOHOL AND OBESIT DISEASE (AD) WITH NEUROINFLAMMATION AND NEURODEGENERATION AS THE CENTRAL LINK. WE ALSO CONDUCTED IPA ANALYSIS TO EXAMINE THE PATHS FROM ALCOHOL AND OBESITY TO AD. BOTH ALCOHOL AND OBESITY WERE LINKED TO AD WITH ALCOHOL EXHIBITING AN OVERALL ACTIVATION OF AD DEVELOPMENT. THESE STUDIES ALSO REVEALED A CRITICAL KNOWLEDGE GAP ON BINGE ETOH (BE) AUGMENTATION OF OBESITY-INDUCED NEUROINFLAMMATION AND NEURODEGENERATION. AS ESSENTIAL NUTRIENTS AND FUNDAMENTAL COMPONENTS OF NEURONAL AND GLIAL CELL MEMBRANES, N-3 POLYUNSATURATED FATTY ACIDS (PUFAS) HAVE BEEN REPORTED WITH ANTI-INFLAMMATORY PROPERTIES AND BENEFICIAL EFFECTS IN ELDERLY WITH MILD COGNITIVE IMPAIRMENT. OUR LABORATORY USED 5-WEEK 3-DAY EACH WEEK BE TO MIMIC BD OVER THE WEEKENDS AND FOUND THAT DOCOSAHEXAENOIC ACID (DHA; 22:6N-3), A PUFA, AMELIORATES BE-INDUCED INFLAMMATION IN HIV-1 TRANSGENIC RATS, AN ANIMAL MODEL FOR HIV/AIDS PATIENTS ON COMBINATION ANTIRETROVIRAL THERAPY. USING IPA, WE FOUND THAT N-3 PUFAS MAY DECREASE THE PRODUCTION OF AMYLOID PRECURSOR PROTEIN (APP), A KEY MOLECULE ASSOCIATED WITH THE ONSET AND PROGRESSION OF AD. TAKEN THESE SOLID PREMISES TOGETHER, WE HYPOTHESIZE THAT BE MAY AUGMENT OBESITY-INDUCED NEUROINFLAMMATION AND NEURODEGENERATION WHILE N-3 PUFAS MAY ATTENUATE BE-INDUCED NEUROINFLAMMATION AND NEURODEGENERATION. TO TEST THESE HYPOTHESES, WE WILL USE A DIET-INDUCED-OBESITY MOUSE MODEL BY FEEDING C57BL/6J MICE WITH CONTROL 10 KCAL% FAT DIET (CD), DHA-SUPPLEMENTED CD (DCD), 45% KCAL% HIGH FAT DIET (HFD), DHA-SUPPLEMENTED 45 KCAL% HIGH FAT DIET (DHFD) AND PROPOSE TWO AIMS. AIM 1 IS TO EXAMINE THE EFFECTS OF BE ON NEUROINFLAMMATION AND NEURODEGENERATION AT THE CELLULAR LEVEL IN THE BRAIN OF MICE FED WITH CD, DCD, HFD, OR DHFD WITH OR WITHOUT BE USING IMMUNOFLUORESCENCE STAINING AND FLUORO-JADE B STAINING. AIM 2 IS TO EXAMINE THE EFFECTS OF BE ON NEUROINFLAMMATION AND NEURODEGENERATION AT THE MOLECULAR LEVEL IN THE BRAIN OF MICE FED WITH CD, DCD, HFD, OR DHFD WITH OR WITHOUT BE USING RNA-SEQUENCING, ANTIBODY ARRAYS, AND BIOINFORMATIC ANALYSIS. THESE STUDIES ARE HIGHLY SIGNIFICANT WITH CLINICAL RELEVANCE. SUCCESSFUL COMPLETION OF THESE STUDIES WILL SHED LIGHT ON WHETHER AND HOW BE MAY AUGMENT OBESITY-INDUCED NEUROINFLAMMATION AND NEURODEGENERATION AND ON WHETHER AND HOW N-3 PUFAS MAY AFFECT BE-INDUCED NEUROINFLAMMATION AND NEURODEGENERATION. THE STUDY OUTCOMES SHALL SHIFT THE PARADIGM REGARDING INTERACTION BETWEEN BD AND DIET-MEDIATED PATHOLOGIES INCLUDING CHARACTERIZATION OF N-3 PUFAS IN PREVENTING THE ONSET AND PROGRESSION OF AD PATHOLOGIES.

METHAMPHETAMINE ACTIONS ON RECOVERY OF THE BBB DAMAGE RELATED TO HIV

USING THE COLLABORATIVE CROSS FOR MODEL STUDIES OF INTESTINAL CANCER

UNDERSTANDING THE VOICE CONTROL SYSTEM IN PARKINSON'S DISEASE

ALCOHOL-INDUCED IMPAIRMENT OF ENDOTHELIAL CELL RECOVERY

GLIAL-NEURONAL INTERACTIONS UNDERLYING THE MOLECULAR FEEDBACK BETWEEN HIV VIRAL P

INVOLVEMENT OF TRP CHANNELS IN ETHANOL CONCENTRATION-DEPENDENT EFFECTS ON IMMUNE

NURSE FACULTY LOAN PROGRAM

IL-1?? AS A MEDIATOR OF MATERNAL INFECTION-INDUCED EFFECTS ON OFFSPRING NEUROINFL

NURSE FACULTY LOAN PROGRAM

13TH-17TH CONFERENCES: DRUG ABUSE, IMMUNE MODULATION AND AIDS

STUDENT SUPPORT SERVICES PROGRAM AT SETON HALL UNIVERSITY

DEVELOPMENT OF TRANSCRIPTOME-BASED BIOMARKERS FROM MELANOMA IN HYBRID FISH

LEAPS-MPS: DEVELOPMENT OF NEW PHOTOACID CATALYZED REACTIONS FOR ORGANIC SYNTHESIS

CRII: SHF: SYSTEMATIC CONSTRUCTION OF TEACHING LANGUAGE PROGRESSIONS FOR EMBEDDED DOMAIN-SPECIFIC LANGUAGES -THE PROJECT EXPLORES THE DEVELOPMENT OF TEACHING LANGUAGE PROGRESSIONS FOR EMBEDDED DOMAIN-SPECIFIC LANGUAGES (EDSLS), FOCUSING ON MAKING PROGRAMMING MORE ACCESSIBLE TO NOVICE LEARNERS. IT ADDRESSES THE CHALLENGING TRANSITION FROM BASIC PROGRAMMING TO ADVANCED EDSLS. THE PROJECT'S NOVELTIES ARE ITS APPROACH TO SIMPLIFY EDSLS INTO STARTER VERSIONS, GRADUALLY INTRODUCING COMPLEXITY, AND ITS METHODOLOGY TO CONSTRUCT THESE TEACHING LANGUAGES BY REPURPOSING EXISTING EDSL COMPONENTS. THE PROJECT'S IMPACTS ARE SIGNIFICANT, AIMING TO DEMOCRATIZE PROGRAMMING EDUCATION AND ENHANCE LEARNERS' GRASP OF COMPLEX PROGRAMMING LANGUAGES, ULTIMATELY CONTRIBUTING TO A MORE INCLUSIVE AND SKILLED PROGRAMMING COMMUNITY. IN A MORE TECHNICAL SCOPE, THE PROJECT EMPLOYS A STRUCTURED APPROACH TO CREATE TWO TAILORED TEACHING EDSLS (TEDSLS), SPECIFICALLY FOR ALGEBRAIC PATTERN MATCHING AND CONSTRAINT LOGIC PROGRAMMING. THESE TEDSLS ARE DESIGNED TO EVOLVE IN COMPLEXITY, ALIGNING WITH THE LEARNERS' GROWING PROFICIENCY. THE INVESTIGATOR WILL CONDUCT A PILOT STUDY WITH NOVICE STUDENTS TO EVALUATE THE EFFECTIVENESS OF THESE TEDSLS, ASSESSING BOTH LEARNING OUTCOMES AND ENGAGEMENT LEVELS. THIS ENDEAVOR IS EXPECTED TO YIELD SIGNIFICANT ADVANCES IN PROGRAMMING LANGUAGE DESIGN AND COMPUTER SCIENCE EDUCATION, FOSTERING AN EASIER TRANSITION FOR LEARNERS TO MASTER EXPERT-LEVEL EDSLS AND POTENTIALLY SHAPING FUTURE PEDAGOGICAL STRATEGIES IN PROGRAMMING EDUCATION. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

FROM LOCAL TO GLOBAL: LANGUAGES FOR PROFESSIONAL SUCCESS AND THE COMMON GOOD

NURSE FACULTY LOAN PROGRAM

MOLECULAR BASIS OF MU-OPIOID RECEPTOR GENE REGULATION

NURSE FACULTY LOAN PROGRAM

INVESTIGATION OF COLD PLASMA FOR HEALING ALCOHOL-INDUCED TISSUE INJURY - ABSTRACT: BINGE DRINKING OF ALCOHOL BEVERAGES HINDERS TISSUE REPAIR AND AMPLIFIES THE SUSCEPTIBILITY TO INFECTION. THE PREVALENCE AS WELL AS THE RISKS ASSOCIATED WITH BINGE DRINKING POSES A SIGNIFICANT CONCERN IN THE UNITED STATES. BINGE DRINKING IMPAIRS THE THREE KEY PHASES OF WOUND HEALING: INFLAMMATION, PROLIFERATION, AND REMODELING. SPECIFICALLY, DURING THE INFLAMMATION PHASE, BINGE DRINKING DIMINISHES THE FUNCTION OF PRO-INFLAMMATORY CYTOKINES, NEUTROPHILS, AND MACROPHAGES, THUS COMPROMISING THE INNATE IMMUNE SYSTEM'S ABILITY TO COMBAT PATHOGENS. THE EFFICACY OF CURRENT WOUND HEALING METHODS IS CONSTRAINED BY THE VULNERABILITY TO WOUND INFECTION WHICH IS EXACERBATED BY CONCURRENT BINGE DRINKING. COLD PLASMA (CP) HAS RECENTLY GAINED SUBSTANTIAL ATTENTION IN CLINICAL PRACTICE DUE TO ITS REGENERATIVE PROPERTIES AND ITS ABILITY TO PREVENT INFECTION. PREVIOUS STUDIES HAVE SHOWN THAT CP TREATMENT IS INVOLVED IN THE WOUND HEALING MEDIATED BY THE NRF2 PATHWAY AND WNT/Β‑CATENIN SIGNALING PATHWAY. TAKEN THESE SOLID PREMISES TOGETHER, WE HYPOTHESIZE THAT CP WILL IMPROVE IMPAIRED WOUND HEALING AND MITIGATE THE INCREASED VULNERABILITY TO INFECTION CAUSED BY BINGE DRINKING. TO SUBSTANTIATE THESE HYPOTHESES, WE HAVE PROPOSED TWO FOLLOWING SPECIFIC AIMS USING F344 RAT MODEL AND HUMAN SKIN ORGANOID MODEL, RESPECTIVELY. AIM 1 IS TO CHARACTERIZE WOUND HEALING PROPERTIES OF CP IN F344 RATS FOLLOWING BINGE EXPOSURE TO ALCOHOL. THIS AIM IS TO EXAMINE WOUND CLOSURE PROPERTIES OF CP AND TO REVEAL MOLECULAR MECHANISMS UNDERLYING CP MODULATION OF WOUND HEALING IN BINGE ETOH INTOXICATED F344 RATS. AIM 2 IS TO GENERATE AN IN-VITRO WOUND HEALING MODEL USING HIPSC DERIVED SKIN ORGANOIDS AND TO INVESTIGATE THE POTENTIAL WOUND HEALING PROPERTIES OF CP IN THESE SKIN ORGANOIDS GIVEN BINGE LEVEL OF ETOH. THIS AIM REPRESENTS THE TRANSLATIONAL ASPECT OF OUR STUDIES. WE FIRST WILL DEVELOP AND CHARACTERIZE 3D SKIN ORGANOIDS USING HUMAN INDUCED PLURIPOTENT STEM CELLS (HIPSC) AND THEN IDENTIFY THE POTENTIAL WOUND HEALING PROPERTIES OF CP IN ALCOHOL-TREATED HUMAN SKIN ORGANOIDS. IN ADDITION, WE WILL STUDY MOLECULAR MECHANISMS AND SIGNAL PATHWAYS UNDERLYING CP MODULATION OF WOUND HEALING IN ALCOHOL TREATED SKIN ORGANOIDS USING BOTH IMMUNOFLUORESCENCE AND GENE EXPRESSION ANALYSIS. THESE STUDIES ARE HIGHLY SIGNIFICANT BECAUSE 1) WE ARE TO DEMONSTRATE THE MEDICAL USE OF CP IN WOUND HEALING ASSOCIATED WITH ETOH INTOXICATION, AND 2) WE ARE TO ADDRESS THE TRANSLATIONAL VALUE OF THE PROPOSED STUDIES USING F344 RAT MODEL AND HUMAN CULTURE OF SKIN ORGANOIDS. SUCCESSFUL COMPLETION OF THIS SMALL R03 GRANT AWARD WILL PROVIDE VALUABLE THERAPEUTIC CLUES IN CP MODULATION OF THE WOUND HEALING DURING ETOH INTOXICATION. THE STUDY OUTCOMES SHALL SHIFT THE PARADIGMS REGARDING THE INTERPLAY BETWEEN WOUND HEALING PROPERTIES OF CP AND ALCOHOL- INDUCED IMPAIRMENT OF WOUND HEALING, EVENTUALLY LEADING TO CLINICAL APPLICATION OF CP IN WOUND HEALING DURING ETOH INTOXICATION. WE EXPECT A FULL R01 PROJECT TO BE DEVELOPED IN CONCLUSION OF THIS SMALL R03 PROJECT.

NK CELL-DEPENDENT CANCER IMMUNOTHERAPY WITH SEMI-SYNTHETIC PEPTIDE-PROTEIN BIO-CONJUGATES

BUSINESS HUMANITIES MINOR [SETON HALL UNIVERSITY?S (SHU) PROPOSED INTERDISCIPLINARY BUSINESS HUMANITIES MINOR AND SEVEN NEWLY DEVELOPED COURSES AIMS TO OVERCOME WHAT HAS BEEN IDENTIFIED AND DISCUSSED BY SCHOLARS FOR OVER A CENTURY, THAT THE SEPARATION OF THE HUMANITIES FROM BUSINESS IS ARTIFICIAL AND DETRIMENTAL.]

MRI: ACQUISITION OF A BENCH-TOP FLOW CYTOMETER FOR MULTI-DISCIPLINARY RESEARCH AND EDUCATION AT SETON HALL UNIVERSITY

RUI - THE POLITICAL ECONOMY OF IMF SURVEILLANCE

NURSE FACULTY LOAN PROGRAM

I-CORPS: ANTIFUNGAL INHIBITORS -THE BROADER IMPACT OF THIS I-CORPS PROJECT IS TO PROVIDE TECHNOLOGY TO COMBAT THE DEVELOPMENT OF ANTIMICROBIAL RESISTANCE IN FUNGI. THERE ARE ONLY THREE MAIN CLASSES OF ANTIFUNGAL DRUGS USED TO TREAT THE MOST COMMON FUNGAL INFECTIONS. SPECIES SUCH AS CRYPTOCOCCUS NEOFORMANS HAVE RESISTANCE TO A LARGE PORTION OF ONE OR MORE CLASSES OF ANTIFUNGALS. THIS MEANS THAT MUCH HIGHER DOSES OF THESE DRUGS ARE NEEDED THAN USUAL. CLINICAL MANAGEMENT OF THESE CASES CAN BE DIFFICULT, CAUSING EXTREME HEALTH DIFFICULTIES AS WELL AS ECONOMIC HARDSHIPS FOR VULNERABLE POPULATIONS LIKE PEOPLE WHO ARE ELDERLY OR WHO ARE IMMUNOCOMPROMISED WITH HIV/AIDS. THE ISSUES ARE FURTHER EXACERBATED BY POOR ANTIMICROBIAL STEWARDSHIP IN AGRICULTURE WHERE OVERUSE OF THESE SAME ANTIFUNGALS IS LEADING TO A RISE IN DRUG RESISTANCE EVEN OUTSIDE OF THE CLINIC. TECHNOLOGY IS NEEDED TO IMPROVE THE ACTIVITY OF EXISTING ANTIMICROBIAL DRUGS AND MAKE THEM SAFE AND EFFECTIVE FOR USE AGAINST EVEN THE MOST CHALLENGING DRUG-RESISTANT STRAINS. THIS PROJECT SEEKS TO IDENTIFY THE MARKET POTENTIAL FOR TECHNOLOGY THAT CAN LOWER THE DOSES OF DRUGS NEEDED TO TREAT RESISTANT FUNGI. THIS TECHNOLOGY HAS THE POTENTIAL TO IMPACT A MULTI-BILLION-DOLLAR INDUSTRY AND KEEP THE EXISTING CLASSES OF ANTIFUNGALS USEFUL FOR MANY YEARS TO COME. THE PROJECT IS BASED ON THE DEVELOPMENT OF ANTIMICROBIAL PEPTIDES FROM THE OUTER LOOP REGION OF THE C. NEOFORMANS P4-ATPASE ENZYME. THE ENZYME CONTROLS THE MOVEMENT OF LIPIDS FROM THE OUTER SURFACE OF THE CELL TO THE INSIDE OF THE CELL. THE FUNGUS C. NEOFORMANS IS RESISTANT TO THE DRUG CASPOFUNGIN. IT WAS FOUND THAT REMOVING CDC50 MAKES TREATMENT WITH CASPOFUNGIN EASIER. PREVENTING THE MOVEMENT OF LIPIDS LEAVES THE FUNGAL CELLS VULNERABLE TO ATTACK FROM CASPOFUNGIN AND SOME OF THE MAIN CLASSES OF ANTIFUNGAL DRUGS. THE ANTIMICROBIAL PEPTIDES BLOCK THE MOVEMENT OF THE LIPIDS, AND THEY CAN THEREFORE BE USED IN A COMBINATION TREATMENT WITH OTHER ANTIFUNGAL DRUGS. TO THIS END, A PATENT HAS BEEN FILED TO SUPPORT THE DEVELOPMENT OF THE TECHNOLOGY. SEVERAL PAPERS HAVE BEEN PUBLISHED AND/OR ARE IN PREPARATION RELATED TO THIS TECHNOLOGY. WORK WILL CONTINUE TO BE DONE TO IMPROVE THE PEPTIDE ACTIVITY AND MAKE THE MOST EFFECTIVE TREATMENT POSSIBLE. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

ADVANCED EDUCATION NURSING TRAINEESHIP

TO SUPPORT A PROJECT TO PROCESS COLLECTIONS OF PAPERS OF FIVE PATHBREAKING NEW JERSEY POLITICIANS: ARTHUR A. QUINN (1856-1957), STATE LEGISLATOR AND LABOR LEADER, BERNARD MICHAEL SHANLEY (1903-1992) WHO SERVED ON THE WHITE HOUSE STAFF DURING THE EISENHOWER ADMINISTRATION, RICHARD JOSEPH HUGHES (1909-1992), NEW JERSEY?S FIRST CATHOLIC GOVERNOR (1962-1970), BRENDAN BYRNE (1924-2018), GOVERNOR OF NEW JERSEY FROM 1974 TO 1982, AND DONALD PAYNE (1934-2012), FIRST AFRICAN AMERICAN MEMBER OF THE U.S. HOUSE OF REPRESENTATIVES FROM NEW JERSEY (1989-2012)

A BUSINESS HUMANITIES INITIATIVE

EFFECTS OF ETHANOL CONCENTRATION IN BINGE DRINKING DURING HIV-1 INFECTION

PARTIAL ORGANIZATIONAL SUPPORT FOR THE 3RD SUMMER INSTITUTE ON COMPLEX PLASMAS. CONFERENCE TO BE HELD JULY 30TH - AUG 8, 2012 AT SETON HALL IN NEW JE

PARTIAL ORGANIZATIONAL SUPPORT FOR THE 4TH SUMMER INSTITUTE ON COMPLEX PLASMAS TO BE HELD JULY 30TH TO AUGUST 8TH, 2014 AT SETON HALL UNIVERSITY IN S

PARTIAL SUPPORT FOR THE 3RD SUMMER INSTITUTE ON COMPLEX PLASMAS

ORGANIZATIONAL SUPPORT FOR THE 3RD SUMMER INSTITUTE ON COMPLEX PLASMAS, JULY 30-AUGUST 8, 2012

EAGER: HETEROGENIZED FLUOROPHTHALOCYANINE CATALYSTS

NASA STEM EDUCATION AND ACCOUNTABILITY PROJECTS (SEAP))SCHOLARSHIP PROGRAM - 2015

NURSE FACULTY LOAN PROGRAM

SETON HALL UNIVERSITY SCIENCE AND TECHNOLOGY CENTER (NJ)