Sphere Inc

DESCRIPTION:THE SPHERE INSTITUTE'S BAY RISE PARK PROJECT (THE PROJECT) IS THE TRANSFORMATION OF A 9.4-ACRE STATE PARCEL AT 410 AIRPORT BOULEVARD, BURLINGAME INTO A NEW PUBLIC PARK AND TIDAL MARSH HABITAT. THE OVERALL PROJECT, LOCATED ON RECLAIMED LAND ON THE EDGE OF SAN FRANCISCO BAY, WILL RESTORE TIDAL WETLANDS AND TRANSITION-ZONE HABITATS ABSENT FROM THE BURLINGAME SHORELINE, PROVIDE EDUCATIONAL AND RECREATIONAL AMENITIES, IMPROVE THE BAY TRAIL, AND DEMONSTRATE HOW GREEN INFRASTRUCTURE CAN PROTECT THE BAYFRONT. THE PROJECT TEAM WILL COLLABORATE WITH THE SAN MATEO COUNTY FLOOD AND SEA-LEVEL RISE RESILIENCY DISTRICT ('ONESHORELINE') TO INTEGRATE THE PARK DESIGN WITH THEIR EMERGING REGIONAL SOLUTION FOR FLOOD PROTECTION ALONG THE COUNTY SHORELINE. THE GRANT SUPPORTS CONSTRUCTION DRAWINGS, PLANNING CONSULTATION FOR PERMITS AND REGULATORY APPROVAL, AND INITIAL IMPLEMENTATION/CONSTRUCTION COSTS. THIS ASSISTANCE AGREEMENT PROVIDES FULL FEDERAL FUNDING IN THE AMOUNT OF $3,000,000. PREAWARD COSTS ARE APPROVED BACK TO 6/1/2023.ACTIVITIES:TO IMPLEMENT THE SAN FRANCISCO ESTUARY PARTNERSHIP COMPREHENSIVE CONSERVATION AND MANAGEMENT PLAN (CCMP), THE SPHERE INSTITUTE'S BAY RISE PARK PROJECT WILL ACCOMPLISH THE FOLLOWING ACTIVITIES: COMPLETE CONSTRUCTION DRAWINGS, PLANNING CONSULTATION FOR PERMITS AND REGULATORY APPROVAL, AND INITIAL IMPLEMENTATION/CONSTRUCTION. THESE ACTIVITIES WILL SUPPORT THE OVERALL LARGER BAY RISE PARK PUBLIC PARK AND TIDAL MARSH HABITAT PROJECT IN BURLINGAME.SUBRECIPIENT:THE SPHERE INSTITUTE WILL BE WORKING WITH THE SAN MATEO RESOURCE CONSERVATION DISTRICT AS A PROJECT PARTNER IN HELPING TO MANAGE A GENERAL CONTRACTOR TO SUPPORT THE BAY RISE PARK PROJECT.OUTCOMES:ANTICIPATED DELIVERABLES INCLUDE: COMPLETING THE PROJECT DESIGN, SECURING BUILDING PERMITS FROM THE CITY OF BURLINGAME, ACHIEVING REGULATORY MILESTONES, PREPARING A QUALITY ASSURANCE PROJECT PLAN, CONTINUING COMMUNITY OUTREACH, BEGINNING INITIAL CONSTRUCTION, AND DEVELOPING A LONG-TERM TIDAL MARSH HABITAT RESTORATION AND MONITORING PLAN AND REPORTING REQUIREMENTS. EXPECTED LONGER-TERM OUTCOMES INCLUDE: APPROXIMATELY 5 ACRES OF RESTORED TIDAL MARSH, TRANSITION ZONE, AND UPLAND HABITATS PARK AND RESTORED, HABITAT COMPLETE AND OPERATIONAL, PROVIDING IMPROVED ENVIRONMENTAL CONDITIONS, HABITAT FOR LOCAL WILDLIFE, AND ACCESSIBLE RECREATIONAL AND EDUCATIONAL AMENITIES FOR THE PUBLIC. THE INTENDED BENEFICIARIES OF THIS PROJECT ARE THE COMMUNITIES AND VISITORS WHO WOULD VISIT BAY RISE PARK IN BURLINGAME AND THE LIVING RESOURCES OF THE SAN FRANCISCO BAY AND ITS WATERSHEDS.

EARMARK SUPPORT FOR STEM EDUCATION PROGRAMS AND GALLERIES/EXHIBITS REVITALIZATION

NOVEL BROAD-SPECTRUM POINT-OF-CARE COAGULOMETER - PROJECT SUMMARY/ABSTRACT WORK UNDER THIS PROPOSAL SUPPORTS DEVELOPMENT OF A BROAD-SPECTRUM POINT-OF-CARE (POC) COAGULOMETER BY PEROSPHERE TECHNOLOGIES (THE PEROSPHERE TECHNOLOGIES POC COAGULOMETER) WITH THE INTENT TO CREATE AND OFFER AN AUTOMATED, MICROFLUIDIC VERSION OF THE MANUAL LEE/WHITE CLOTTING TIME METHOD. THE DEVICE IS BASED ON NOVEL TECHNOLOGY AND UTILIZES REAGENT-LESS, SINGLE-USE MICROFLUIDIC CUVETTES MADE OF SILICON AND GLASS FOR MEASUREMENT OF BLOOD SAMPLES. CLOT ACTIVATION OCCURS AT THE BEGINNING OF THE INTRINSIC CLOTTING PATHWAY THROUGH CONTACT OF A BLOOD SAMPLE WITH THE INNER GLASS AND SILICON SURFACES OF THE CUVETTE. THE DEVICE DETECTS CLOT FORMATION BY MONITORING THE INTENSITY OF NEAR-INFRARED LIGHT, TRANSMITTED THROUGH CUVETTE AND BLOOD SAMPLE, AND SENSING OF FIBRIN ASSEMBLY AT THE END OF THE COMMON CLOTTING PATHWAY. THE CLOT DETECTION SCHEME AFFORDS DEVELOPMENT OF TWO MAIN ASSAYS, A CLOTTING TIME ASSAY, THAT MEASURES THE TIME TO ONSET OF CLOT FORMATION AND IS CURRENTLY IMPLEMENTED ON THE COAGULOMETER PLATFORM, AND A CLOT LYSIS TIME ASSAY, THAT MEASURES THE TIME TO ONSET OF SUBSEQUENT CLOT BREAKDOWN AND IS IN DEVELOPMENT. RESEARCH INDICATES THAT THE DEVICE IS BROADLY SENSITIVE TO THE EFFECTS OF ANTICOAGULANTS ACROSS DRUG CLASS, THEIR REVERSAL AGENTS AND THROMBOLYTIC DRUGS. INITIAL MARKETING EFFORTS WILL FOCUS ON USE OF THE DEVICE WITH IMPLEMENTED CLOTTING TIME ASSAY FOR MONITORING OF THE DIRECT ORAL ANTICOAGULANTS (DOACS) AND LOW MOLECULAR WEIGHT HEPARINS (LMWHS). RESEARCH UNDER THIS PROPOSAL TARGETS ESTABLISHMENT OF CLOTTING TIME REFERENCE RANGES FOR HEALTHY VOLUNTEERS AND PATIENTS ON THE DOACS RIVAROXABAN, APIXABAN, DABIGATRAN AND EDOXABAN, IN DIRECT SUPPORT OF INITIAL MARKETING GOALS. IN SUPPORT OF FUTURE DEVICE APPLICATIONS, THE RESEARCH ALSO TARGETS ASSESSMENT OF THE DEVICE’S ABILITY TO DETECT INHERITED OR ACQUIRED COAGULOPATHIES, BASED ON ABNORMAL CLOTTING TIMES, AS WELL AS ASSESSMENT OF THE DEVICE’S SENSITIVITY TO ABELACIMAB, A NOVEL ANTICOAGULANT AND DIRECT FACTOR XI/XIA INHIBITOR, CURRENTLY IN CLINICAL DEVELOPMENT. PEROSPHERE TECHNOLOGIES INTENDS TO COMMERCIALIZE THE DEVICE THROUGH A MARKETING, SALES AND DISTRIBUTION PARTNERSHIP WITH A GLOBAL MEDICAL DEVICE COMPANY. THE DEVICE IS SIMILARLY SUITED FOR USE IN EMERGENCY SITUATIONS (E.G. EMERGENCY ROOM, EMERGENCY VEHICLE) AND FOR ROUTINE CARE IN THE INPATIENT AND OUTPATIENT SETTINGS (HOSPITALS, CLINICS, SURGICAL SUITES, DOCTOR’S OFFICES, PHARMACIES) BY HEALTHCARE PROFESSIONALS WHO CAN PERFORM OR ORDER FRESH VENOUS WHOLE BLOOD DRAWS. THE DEVICE PROMISES TO ADDRESS SEVERAL UNMET MEDICAL NEEDS, INCLUDING POINT-OF- CARE MONITORING OF DOACS, AND HAS THE POTENTIAL TO DEFINE NEW STANDARDS OF CARE. THE DEVICE IS EXPECTED TO IMPROVE PATIENT CARE, CLINICAL OUTCOME AND TO REDUCE HEALTHCARE COSTS, BY PROVIDING PHYSICIANS WITH THE MEANS TO MAKE FASTER AND BETTER-INFORMED TREATMENT DECISIONS. THE DEVELOPED CLOTTING TIME AND CLOT LYSIS TIME ASSAYS WILL PRESENT A NEW WAY TO DESCRIBE A PATIENT’S COAGULATION STATE AND ENABLE OPPORTUNITIES FOR FUNDAMENTAL RESEARCH OF DISEASE MECHANISMS AND THERAPEUTIC APPROACHES.

SBIR PHASE II: BIOPARTICLE DELIVERY OF DSRNA: A NOVEL PEST MANAGEMENT SOLUTION FOR CONTROL OF FALL ARMYWORM

NATIONAL TRAINING AND TECHNICAL ASSISTANCE

DEVELOPMENT OF THE POST ACUTE CARE SUPPLEMENT (PACS) RESEARCH FILES

AN ASSISTANCE AWARD TO DEFINE, PROMOTE AND APPLY HUMANITARIAN PRINCIPLES AND MINIMUM STANDARDS TO ENSURE LIFESAVING, PROTECTIVE AND ACCOUNTABLE RESPONSE TO CRISIS. FOCUS WILL BE ON THE HUMANITARIAN POLICY, STUDIES, ANALYSIS, OR APPLICATIONS SECTOR, WITH INTENT TO IMPROVE AND SUSTAIN CONSISTENCY IN BOTH QUALITY AND ACCOUNTABILITY OF HUMANITARIAN ACTION THROUGHOUT THE WORLD.

LOST RIVER PRESERVE - FISHERIES HABITAT RESTORATION PROJECT

A GRANT PROPOSAL BY THE COSMOSPHERE INTERNATIONAL SCIED CENTER AND SPACE MUSEUM (THE COSMOSPHERE) FOR STEM PROGRAMMING AND OUTREACH TO BUILD ON THE LESSONS LEARNED DURING THE APOLLO-ERA FROM THE MISSION CONTROL PERSPECTIVE OF MAKING INFORMED DECISIONS WHEN UNDER STRESS AND WITH LIMITED TIME. THIS PROJECT WILL BRING AUTHENTIC APOLLO-ERA MISSION CONTROL CONSOLES OUT OF STORAGE AND INTO CLASSROOMS MUSEUMS AND CHALLENGER LEARNING CENTERS (CLCS) AROUND THE COUNTRY AND BEYOND. IF THE CONSOLES COULD TELL THEIR STORY WHAT THEY DID THE LIVES OF THOSE WHO USED THEM THE IMPORTANCE OF THE THOUSAND OR MORE PEOPLE WHO WORKED TOGETHER TO GET THE FIRST MEN TO THE MOON AND BACK SAFELY IT WOULD BE A FASCINATING TALE FOR CERTAIN! MEN AND WOMEN WHO WERE INVOLVED IN APOLLO SHUTTLE AND NOW INTERNATIONAL SPACE STATION MISSIONS CAN TELL THE STORY. WE HAVE HISTORIC EQUIPMENT THAT CAN TRAVEL TELL ITS STORIES AND ALLOW THE VISITOR OR STUDENT TO INSERT THEMSELVES INTO A REAL MISSION. IN THE APOLLO REDUX PROJECT PARTICIPANTS WILL NEED TO TRAIN AND UNDERSTAND THE MISSION THEIR ROLE IN IT AND THE IMPORTANCE OF THOSE WORKING WITH THEM. ONLY THEN WILL THEY BE READY TO FLY A MISSION AND TEST THEIR KNOWLEDGE TEAMWORK LEADERSHIP AND PROBLEM-SOLVING SKILLS. UPON COMPLETION OF THEIR MISSION THEY WILL HAVE A NEW APPRECIATION OF NASA HISTORICAL SUCCESSES AND FUTURE MISSIONS BACK TO THE MOON TO MARS OR EVEN TO AN ASTEROID.

MANGROVE/SALTERN RESTORATION ACTIVITIES AT MACDILL AFB

THIS AGREEMENT SUPPORTS THE SHORELINE PARK RESTORATION PLANNING PROJECT TO PREPARE THE DESIGNS, PERMITS, AND PLANNING DOCUMENTS NECESSARY TO RESTORE APPROXIMATELY FIVE ACRES OF TIDAL MARSH HABITAT AND TRANSITION ZONE ALONG SAN FRANCISCO BAY. THIS PROJECT IMPLEMENTS WETLANDS, WATER QUALITY AND HABITAT ACTIONS LISTED UNDER THE SAN FRANCISCO ESTUARY PROGRAM, COMPREHENSIVE CONSERVATION MAMANGEMENT PLAN AND WILL BENEFIT THE FISH, WILDLIFE, AND HUMANS THAT DEPEND ON A THRIVING, HEALTHY SAN FRANCISCO BAY. THIS AGREEMENT PROVIDES FULL FEDERAL FUNDING IN THE AMOUNT OF $500,000. PREAWARD COSTS ARE APPROVED BACK TO 9/1/2020.

SBIR PHASE II: SUB-DECADAL WEATHER AND CLIMATE FORECAST SYSTEM TO MITIGATE RISK FOR ENERGY AND NATURAL RESOURCE APPLICATIONS -THE BROADER/COMMERCIAL IMPACT OF THIS SMALL BUSINESS INNOVATION RESEARCH (SBIR) PHASE II PROJECT IS IN POTENTIALLY REDUCING THE DETRIMENTAL IMPACTS OF WEATHER AND CLIMATE ON THE UNITED STATES ENERGY AND INSURANCE MARKETS. TO HELP THE AMERICAN ECONOMY PREPARE FURTHER IN ADVANCE FOR IMPACTFUL WEATHER AND CLIMATE EVENTS, THIS PROJECT WILL DEVELOP A FORECAST SYSTEM THAT CAN TRANSLATE CLIMATE FORECASTS INTO LIKELIHOODS OF IMPACTFUL WEATHER EVENTS. THIS INFORMATION WILL BE USED TO INFORM THE ENERGY AND INSURANCE MARKETS OF FINANCIAL RISK, PARTICULARLY WITHIN THE RENEWABLE ENERGY SECTOR WHERE WEATHER AND CLIMATE CONTROL THE AMOUNT OF ENERGY PRODUCED. RENEWABLE ENERGY IS PRODUCED LOCALLY WITHIN THE UNITED STATES, WHICH MEANS THIS PROJECT WILL IMPROVE THE NATION?S ENERGY SECURITY BY INFORMING WHEN AND WHERE RENEWABLE ENERGY WILL BE MOST AVAILABLE. CONSERVATIVE ESTIMATES OF THE TECHNOLOGY?S POTENTIAL INCLUDE A $2.5 MILLION PER YEAR BENEFIT TO THE RENEWABLE ENERGY INDUSTRY, WITH A SIMILAR MULTI-MILLION DOLLAR IMPACT TO THE MORE GENERAL PARAMETRIC INSURANCE MARKET. THIS PROJECT WILL ENHANCE A CLIMATE FORECAST SYSTEM DEVELOPED DURING THE COMPANY'S NSF SBIR PHASE I AWARD THAT ISSUES CLIMATE FORECASTS UP TO A DECADE INTO THE FUTURE. THE ENHANCEMENTS INCLUDE INCREASED FORECAST ACCURACY THROUGH AUTOMATED MACHINE LEARNING MODEL PARAMETER TUNING, FORECAST POST-PROCESSING, AND THE TRANSLATION OF THE CLIMATE FORECASTS INTO REALISTIC WEATHER PATTERNS. THE TECHNOLOGY USES MACHINE LEARNING TO IDENTIFY PATTERNS IN THE LAND, ATMOSPHERE, AND OCEAN THAT HELP DETERMINE HOW THE CLIMATE SYSTEM WILL EVOLVE ON TIMESCALES OF ONE MONTH TO ONE DECADE. THESE CLIMATE FORECASTS WILL THEN BE TRANSLATED INTO REALISTIC POSSIBILITIES OF FUTURE WEATHER PATTERNS ON DAILY TIMESCALES. THESE DAILY WEATHER PATTERNS CAN THEN BE USED TO INFORM RENEWABLE ENERGY POWER PRODUCTION FORECASTS AND EXTREME WEATHER EVENT RISK FOR NUMEROUS INDUSTRIES, INCLUDING THE ENERGY SECTOR AND THE GENERAL INSURANCE INDUSTRY. A KEY TECHNICAL BENEFIT TO THE PROPOSED FORECAST SYSTEM IS ITS HIGH COMPUTATIONAL SCALABILITY, WHICH ENABLES THE RAPID CREATION OF CLIMATE FORECASTS THAT ARE TYPICALLY PRODUCED USING SUPERCOMPUTERS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

VIVOSPHERES: TISSUE-ENGINEERED SPHEROIDAL MODELS FOR HIGH-THROUGHPUT SCREENING - ABSTRACT THE DEVELOPMENT OF THREE-DIMENSIONAL (3D) DISEASE MODELS HAS PAVED THE WAY FOR ACCELERATED DESIGN, DISCOVERY, AND VALIDATION OF POTENTIAL TARGETS AND DRUG COMPOUNDS, THEREBY SIGNIFICANTLY REDUCING THE TIME, COST, AND LABOR INVOLVED IN THE DRUG DISCOVERY PIPELINE. 3D SPHEROIDAL CELL AGGREGATE MODELS HAVE BEEN ESTABLISHED AS MORE ACCURATE AND PREDICTIVE THAN TWO-DIMENSIONAL (2D) MODELS FOR DRUG SCREENING. HOWEVER, CURRENT COMMERCIAL TECHNIQUES FOR SPHEROIDAL TISSUE FORMATION RELY HEAVILY ON THE SELF-AGGREGATION OF SINGLE CELLS AND HAVE SUBSTANTIAL LIMITATIONS CONCERNING PRODUCTION CONSISTENCY, CONTROL, AND FLEXIBILITY. THAT MAKES VIVOSPHERE A BREAKTHROUGH PRODUCT. VIVOSPHERES ARE CELL-LADEN HYDROGEL MICROSPHERES THAT ARE PRODUCED RAPIDLY USING OUR MICROFLUIDIC PLATFORM. COMPARED TO SELF-AGGREGATION SYSTEMS, INCORPORATION OF HYDROGEL MATRICES IN VIVOSPHERES CAN IMPROVE THE CONSISTENCY OF TISSUES IN SIZE AND SHAPE, WHICH IS CRITICAL IN GETTING HIGH-QUALITY RESULTS IN HIGH-THROUGHPUT SCREENING (HTS), AND PROVIDE THE ABILITY TO MANIPULATE THE CELLULAR MICROENVIRONMENT, WHICH IS AN IMPORTANT DRIVER OF APPROPRIATE CELL PHENOTYPE AND FUNCTION. THE CELL TYPES WILL NO LONGER BE LIMITED TO SELF-AGGREGATING CELLS. INSTEAD, THERE WILL BE GREAT FLEXIBILITY IN SELECTING EITHER AGGREGATING OR NON-AGGREGATING CELLS, AND EVEN MULTIPLE CELL TYPES FOR CO-ENCAPSULATION. THIS PROJECT WILL USE CANCER CELLS TO DEMONSTRATE THE HIGH CONSISTENCY OF VIVOSPHERES AS MORE SUITABLE FOR HTS COMPARED TO SELF-AGGREGATION SYSTEMS, ESTABLISH THE ABILITY TO FORM VIVOSPHERES USING NON-AGGREGATING CANCER CELLS, AND OPTIMIZE KEY ASSAYS USED IN HTS. THE OUTCOME OF THIS PROJECT WILL REMOVE POTENTIAL ROADBLOCKS TO BUILDING DISEASE-SPECIFIC MODELS FOR HTS. VIVOSPHERE IS VIVOSPHERE LLC’S FIRST PRODUCT AND IS PROTECTED BY NON-PROVISIONAL PATENTS.

THE AIM OF THIS AWARD IS TO PROMOTE AWARENESS, UNDERSTANDING, ACCESSIBILITY, LOCALIZATION, OWNERSHIP, APPLICATION AND REVIEW OF SPHERE STANDARDS ACROSS DIVERSE CONTEXTS GLOBALLY.

TO SUPPORT AND EXPAND THE APPLICATION OF GLOBAL HUMANITARIAN STANDARDS FOR LOCAL ACTION AND PREPAREDNESS FOR CRISIS-AFFECTED COMMUNITIES.

TO SUPPORT AND EXPAND THE APPLICATION OF GLOBAL HUMANITARIAN STANDARDS FOR LOCAL ACTION AND PREPAREDNESS FOR CRISIS AFFECTED COMMUNITIES

MASSIVELY MULTIPLEXED RESPIRATORY VIRUS DETECTION SYSTEM

SBIR PHASE I: SUB-DECADAL WEATHER AND CLIMATE FORECAST SYSTEM TO MITIGATE RISK FOR ENERGY AND NATURAL RESOURCE APPLICATIONS

STTR PHASE I: A NOVEL TISSUE-ENGINEERED PLATFORM FOR CANCER MODELING AND DRUG SCREENING -THE BROADER IMPACT OF THIS SMALL BUSINESS TECHNOLOGY TRANSFER PHASE I PROJECT LIES PRIMARILY IN PROVIDING MORE EFFECTIVE DRUG SCREENING MODELS TO ELIMINATE INEFFECTIVE DRUG CANDIDATES AT AN EARLY STAGE. THIS MAY EXPEDITE THE ANTI-CANCER DRUG DEVELOPMENT PROCESS AND REDUCE EXCESSIVE EXPENSES DURING CLINICAL TRIALS, WHICH MAY INCREASE THE R&D RETURNS FOR PHARMACEUTICAL COMPANIES AND REDUCE HEALTHCARE COSTS FOR THE CUSTOMERS. FURTHERMORE, THE SOONER THAT AN EFFICACIOUS ANTI-CANCER DRUG CAN BE BROUGHT TO THE MARKET, THE SOONER THAT PATIENTS CAN DIRECTLY EXPERIENCE IMPROVED HEALTH OUTCOMES. CANCER HAS BEEN ONE OF THE LEADING CAUSES OF DEATH IN THE UNITED STATES AND WORLDWIDE. DEVELOPMENT OF SAFER AND MORE EFFECTIVE ANTICANCER DRUGS CAN PROVIDE PATIENTS THE OPPORTUNITY FOR BOTH A LONGER AND POTENTIALLY BETTER QUALITY OF LIFE. THE PROPOSED TECHNOLOGY MAY ALSO HAVE IMMENSE VALUE FOR PHARMACEUTICAL COMPANIES. IN DRUG DEVELOPMENT, RESEARCHERS SCREEN NUMEROUS COMPOUNDS TO UNDERSTAND DRUG EFFICACY AND DISCARD INEFFECTIVE ONES. 90% OF DRUG CANDIDATES IN THE PIPELINE WILL FAIL, IN PART DUE TO POOR CLINICAL TRANSLATION. THE PRODUCT AIMS TO HELP COMPANIES ELIMINATE INEFFICACIOUS DRUGS EARLIER BEFORE MILLIONS OF DOLLARS ARE SPENT ON THEIR DEVELOPMENT. THE PROPOSED PROJECT WILL DEVELOP A MORE PHYSIOLOGICALLY RELEVANT, CONSISTENT, AND VERSATILE HIGH-THROUGHPUT SCREENING (HTS) MODEL TO IMPROVE THE TRANSLATION RATE BETWEEN PRECLINICAL AND CLINICAL TESTING. CURRENT DRUG SCREENING APPROACHES, WHICH RELY ON TWO-DIMENSIONAL (2D) CELL CULTURES AND THREE-DIMENSIONAL (3D) CELL AGGREGATES, FAIL TO PROVIDE THE NECESSARY MICROENVIRONMENTAL CUES FOR ACCURATELY REPLICATING HUMAN PATIENT DRUG RESPONSES. THEREFORE, THE PROPOSED TECHNOLOGY HAS BEEN DEVELOPED, AIMING TO STRIKE A BALANCE BETWEEN THROUGHPUT, WHICH INCLUDES SCALABILITY AND UNIFORMITY, AND PHYSIOLOGICAL RELEVANCE, SUCH AS THE ABILITY TO MODULATE KEY ATTRIBUTES OF THE TUMOR MICROENVIRONMENT. UTILIZING A TISSUE ENGINEERING TOOLSET, THE 3D HYDROGEL SCAFFOLD OFFERS A MORE PHYSIOLOGICALLY PERTINENT MICROENVIRONMENT FOR CELL GROWTH AND DRUG RESPONSE. MEANWHILE, A PATENTED MICROFLUIDIC CELL ENCAPSULATION PLATFORM ALLOWS FOR THE RAPID AND CONSISTENT PRODUCTION OF THE PRODUCTS, WHICH ARE ESSENTIAL FOR HTS APPLICATIONS. THIS PROJECT AIMS TO 1) TEST ADDITIONAL CANCER CELL TYPES TO DEMONSTRATE THE PLATFORM'S BROAD APPLICABILITY, 2) EXPLORE CRYOPRESERVATION TO REDUCE RESPONSE TIME, AND 3) TRANSITION TO COMMERCIALLY AVAILABLE GMP-GRADE HYDROGEL PRECURSORS TO IMPROVE REPRODUCIBILITY AND SCALABILITY. THESE R&D EFFORTS ARE CRUCIAL FOR DEVELOPING ASSAY-READY KITS AND SERVICES FOR MORE EFFICIENT DRUG SCREENING. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

BIOLOGICAL SUPER-RESOLUTION IMAGING USING HIGH-INDEX MICROSPHERES FOR CANCER RESEARCH APPLICATION

STTR PHASE I: BIOPARTICLE DELIVERY OF DSRNA: A NOVEL PEST MANAGEMENT SOLUTION FOR CONTROL OF WESTERN FLOWER THRIPS

DROPLET-BASED ANALYSIS OF SECRETION AND SORTING (DASS) FOR CHARACTERIZATION AND SELECTION OF INDIVIDUAL IMMUNE CELLS

SBIR PHASE I: LOW COST SPECTROMETER FOR METHANE SENSING

MIXED-PHASE CLOUD CHARACTERIZATION SENSOR

MUSEUMS FOR AMERICA

F18AC00207

SOD MANAGEMENT & MONITORING IN BAY AREA

TO SUPPORT AND EXPAND THE APPLICATION OF GLOBAL HUMANITARIAN STANDARDS FOR LOCAL ACTION AND PREPAREDNESS FOR CRISIS-AFFECTED COMMUNITIES.

FIRE FREE AGRICULTURE ECUADOR

THE AGRICELL: A NOVEL, BIODEGRADABLE DELIVERY TECHNOLOGY FOR ENHANCED CROP PROTECTION WITH MINIMIZED ENVIRONMENTAL TOXICITY

SOD MANAGEMENT & MONITORING IN BAY AREA

CASCADE HEAD BIOSPHERE COLLABORATIVE WILL PROVIDE FIELD BASED AND CLASSROOM-INTEGRATED MEANINGFUL WATERSHED EDUCATIONAL EXPERIENCES (MWEES) FOR ELEMENTARY SCHOOL STUDENTS FROM SOUTH TILLAMOOK AND LINCOLN COUNTIES, OREGON. FIELD EXPERIENCES WILL TAKE PLACE IN THE FORESTED UPLANDS, AND SALMON RIVER AND ESTUARY WITHIN THE UNESCO CASCADE HEAD BIOSPHERE REGION. THE PROJECT WILL PROVIDE THREE TARGETED MODULES FOR STUDENTS ACROSS GRADES 1 TO 6 THAT WILL GIVE THEM KNOWLEDGE OF WORKINGS OF WATERSHED AND ESTUARY FUNCTIONS AND ADDRESS THE DRAMATIC CHANGES IN CLIMATE THAT ARE AFFECTING BOTH THE TERRESTRIAL AND MARINE ENVIRONMENTS ALONG THE COAST, AS WELL AS HUMAN COMMUNITIES. STUDENTS WILL COMPLETE BOTH THEIR CLASSROOM AND FIELD JOURNALING, AND ACTION PROJECTS. THIS TWO-YEAR PROJECT WILL BENEFIT APPROXIMATELY 748 STUDENTS, SOME FROM LOW INCOME FAMILIES.

SEC. 9007 REAP-ENERGY EFFICIENCY IMPROVEMENTS GRANTS (MAN)

TO SUPPORT PERSONNEL AND FACILITIES COSTS IN RESPONSE TO THE COVID-19 PANDEMIC.

HABITAT RESTORATION FOR BLACK RAIL

SOD MANAGEMENT IN CENTRAL CA PHYTOSPHERE

SOD MANAGEMENT & MONITORING IN BAY AREA

SUDDEN OAK DEATH MANAGEMENT AND MONITORING IN THE BAY AREA

PURPOSE: TO SUPPORT A SERIES OF CONCERTS AND A WORKSHOP RECITAL IN RECOGNITION OF AMERICAS 250TH ANNIVERSARY.

CONSERVATION EFFORTS FOR PAGOSA SKYROCKET

THOMAS TRACT HABITAT RESTORATION PROJECT

UPDATING A FIELD GUIDE TO INSECTS AND DISEASES OF CALIFORNIA OAKS AND THE CALIFORNIA OAK DISEASE AND ARTHROPOD DATABASE

PAGOSA SKYROCKET (IPOMOPSIS POLYANTHA) CONSERVATION (MONITORING, PUBLIC OUTREACH, AND PRIORITIZATION OF PROPERTIES FOR CONSERVATION).

SEC 9007 REAP-RENEW ENERGY SYSTEMS GRANTS, $20,000 OR LESS (MAN)

TO RESTORE ESTUARINE AND FRESHWATER HABITAT IN THE TAMPA BAY AREA.

TO SUPPORT THE PRODUCTION OF A VIDEO SERIES EXPLORING SOUNDS AND TECHNIQUES OF CONTEMPORARY PIANO MUSIC. 

EFH FRANKEL PHYTOSPHERE RESEARCH NEW $19647 SPCH39 SPFH39

SEC 9007 REAP-RENEW ENERGY EFFICIENCY IMPROVE GRANTS, $20,000 OR LESS (MAN)

THIS GRANT SUPPORTS THE COSTS INCURRED TO IMPLEMENT MEASURES TO RESPOND TO THE NOVEL CORONAVIRUS 2019 (COVID-19), WHICH MAY INCLUDE WORKPLACE SAFETY, MARKET PIVOTS, RETROFITTING FACILITIES, TRANSPORTATION, WORKER HOUSING, AND MEDICAL EXPENSES. IT PROVIDES NEEDED RELIEF TO THE FOOD PROCESSORS, DISTRIBUTORS, FARMERS MARKETS, AND PRODUCERS FOR THEIR COSTS INCURRED BETWEEN JANUARY 27, 2020, THE DATE UPON WHICH THE PUBLIC HEALTH EMERGENCY WAS DECLARED BY THE U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICE (HHS) UNDER SECTION 319 OF THE PUBLIC HEALTH SERVICE ACT, AND DECEMBER 31, 2021. BENEFICIARIES INCLUDE THE EMPLOYEES OF THE FOOD PROCESSORS, DISTRIBUTORS, FARMERS MARKETS, AND PRODUCERS.

THIS GRANT SUPPORTS THE COSTS INCURRED TO IMPLEMENT MEASURES TO RESPOND TO THE NOVEL CORONAVIRUS 2019 (COVID-19), WHICH MAY INCLUDE WORKPLACE SAFETY, MARKET PIVOTS, RETROFITTING FACILITIES, TRANSPORTATION, WORKER HOUSING, AND MEDICAL EXPENSES. IT PROVIDES NEEDED RELIEF TO THE FOOD PROCESSORS, DISTRIBUTORS, FARMERS MARKETS, AND PRODUCERS FOR THEIR COSTS INCURRED BETWEEN JANUARY 27, 2020, THE DATE UPON WHICH THE PUBLIC HEALTH EMERGENCY WAS DECLARED BY THE U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICE (HHS) UNDER SECTION 319 OF THE PUBLIC HEALTH SERVICE ACT, AND DECEMBER 31, 2021. BENEFICIARIES INCLUDE THE EMPLOYEES OF THE FOOD PROCESSORS, DISTRIBUTORS, FARMERS MARKETS, AND PRODUCERS.

TO SUPPORT THE COMMISSIONING AND PRESENTATION OF A NEW SOLO PIANO WORK BY AMERICAN COMPOSER STEVEN STUCKY.

DETERMINE IF ULTRA LOW COLUME FOLIAR APPLICATION OF POTASSIUM PHOSPHITE CAN STOP PHYTOPHTHORA CINNAMOMI ROOT ROT PROGRESS

CONSERVATION AND DEVELOPMENT OF THE NATURAL, CULTURAL, AND ECONOMIC RESOURCES OF THE SOUTHERN APPALACHIAN REGION.

PURPOSE: TO SUPPORT A SERIES OF MULTIDISCIPLINARY ARTS ACTIVITIES AT NOOSPHERE ARTS.

PURPOSE: TO SUPPORT A PERFORMANCE AND COMMUNITY ENGAGEMENT PROJECT FEATURING NEW MUSIC FOR THE PIANO.

TO SUPPORT A PERFORMANCE AND COMMUNITY ENGAGEMENT PROJECT FEATURING NEW MUSIC FOR THE PIANO.

TO SUPPORT WORKSHOPS AND PERFORMANCES AS PART OF THE SATELLITE SERIES  A PROJECT FEATURING NEW MUSIC FOR THE PIANO.

TO SUPPORT THE SATELLITE SERIES PROJECT FEATURING PERFORMANCES OF NEW PIANO WORKS BY YOUNG EMERGING MUSICIANS.

SEC 9007 REAP-RENEW ENERGY SYSTEMS GRANTS, $20,000 OR LESS (MAN)