Bryn Mawr College

EXPANDQISE: TRACK 2: RESEARCH AND EDUCATION CENTER FOR QUANTUM MATERIALS AND SENSING AT A WOMEN'S COLLEGE -THE PROJECT AIMS TO ESTABLISH A RESEARCH AND EDUCATION CENTER FOR QUANTUM MATERIALS AND SENSING AT BRYN MAWR COLLEGE, A WOMEN?S COLLEGE WITH A SMALL CO-EDUCATIONAL GRADUATE PROGRAM. THE CENTER PLANS TO INTEGRATE RESOURCES FROM HIGHER EDUCATION, AN EXISTING NSF-FUNDED QUANTUM CENTER AT THE JOHNS HOPKINS UNIVERSITY, NATIONAL LABS, AND INDUSTRY TO ADVANCE RESEARCH IN QUANTUM MATERIALS AND QUANTUM SENSING AND TO TRANSFORM EDUCATION AND WORKFORCE DEVELOPMENT. THIS PROJECT IS EXPECTED TO DEVELOP NEW QUANTUM MATERIALS AND ENHANCE QUANTUM METROLOGY, LEADING TO POTENTIAL APPLICATIONS WITH BROAD SOCIETAL BENEFITS, SUCH AS ENERGY-EFFICIENT ELECTRONICS AND ENHANCED BIOMEDICAL IMAGING. THE DEVELOPMENT OF ATOMISTIC MODELING STRATEGIES, MACHINE LEARNING, AND QUANTUM COMPUTING ALGORITHMS CAN SIGNIFICANTLY BENEFIT OTHER SCIENCE AND ENGINEERING FIELDS. THE PROPOSED EDUCATION AND WORKFORCE DEVELOPMENT FOCUS ON BROADENING THE PARTICIPATION OF WOMEN AND OTHER UNDERREPRESENTED GROUPS IN QUANTUM INFORMATION SCIENCE AND ENGINEERING (QISE) AT ALL LEVELS AND DEVELOPING A PIPELINE FROM HIGH SCHOOL TO COLLEGE TO GRADUATE EDUCATION AND INDUSTRY. FIVE RESEARCHERS AND EDUCATORS FROM BRYN MAWR COLLEGE, ALONG WITH COLLABORATORS FROM JOHNS HOPKINS UNIVERSITY, COLORADO STATE UNIVERSITY, UNIVERSITY OF PENNSYLVANIA, AND URSINUS COLLEGE, PROPOSE TO EXPAND THE RESEARCH SCOPE OF THE EXISTING BRYN MAWR NANOMATERIALS AND SPINTRONICS LAB AND ATOMIC AND OPTICAL PHYSICS LAB AND ESTABLISH A RESEARCH AND EDUCATION CENTER FOR QUANTUM MATERIALS AND SENSING AT BRYN MAWR COLLEGE. THE CENTER?S RESEARCH IS BUILT AROUND THREE HIGHLY INTERLINKED THRUSTS: QUANTUM MATERIALS, QUANTUM SENSING, AND QISE EDUCATION RESEARCH. THE CENTER?S RESEARCH METHODOLOGY INCLUDES CLOSED-LOOP QUANTUM MATERIAL DESIGN BY COMBINING THEORETICAL CALCULATION, ATOMISTIC MODELING, AND EXPERIMENTS; STATE-OF-THE-ART FLOATING ZONE CRYSTAL GROWTH, THIN-FILM DEPOSITION, AND NANOFABRICATION METHODS; SYNCHROTRON X-RAY TECHNIQUES AND NITROGEN-VACANCY (NV) CENTER-BASED QUANTUM METROLOGY; AND EVIDENCE-BASED EDUCATION RESEARCH AND NATURAL LANGUAGE PROCESSING (NLP) TECHNOLOGIES. THE CENTER?S RESEARCH ACTIVITIES ARE EXPECTED TO (1) DEVELOP HIGH-QUALITY CRYSTALS, THIN FILMS, NANODISKS, AND DEVICES THAT HOST NANOMETER-SIZED SKYRMIONS WITH THE HELICITY DEGREE OF FREEDOM; (2) ADVANCE THE NV-QUBIT BASED CRYOGENIC NANOSCALE SPATIAL MAPPING OF SPIN STRUCTURES; (3) ENHANCE UNDERSTANDING OF FUNDAMENTAL MAGNETIC PROPERTIES OF CENTROSYMMETRIC FRUSTRATED MAGNETS, COVALENT 2D MAGNETS, AND MAGNETIC NANODISKS; (4) PROVIDE EXPERIMENTAL EVIDENCE OF THE QUANTUM NATURE OF NANOSKYRMIONS AND PAVE THE WAY FOR BUILDING A NEW TYPE OF MACROSCOPIC QUBIT -- SKYRMION QUBITS; AND (5) ADVANCE QISE EDUCATION BY INTEGRATING NLP TECHNOLOGIES AND DEVELOPING TEACHING RESOURCES WITH PAIRED ASSESSMENT TOOLS FOR UNDERGRADUATE AND K-12 EDUCATION. THIS AWARD IS CO-FUNDED BY THE ADVANCING INFORMAL STEM LEARNING PROGRAM. THIS PROJECT IS ALSO CO-FUNDED BY THE INNOVATIVE TECHNOLOGY EXPERIENCES FOR STUDENTS AND TEACHERS (ITEST) PROGRAM, WHICH SUPPORTS PROJECTS THAT BUILD UNDERSTANDINGS OF PRACTICES, PROGRAM ELEMENTS, CONTEXTS AND PROCESSES CONTRIBUTING TO INCREASING STUDENTS' KNOWLEDGE AND INTEREST IN SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS (STEM) AND INFORMATION AND COMMUNICATION TECHNOLOGY (ICT) CAREERS. SUPPORT FOR THIS PROJECT IS PROVIDED BY THE IMPROVING UNDERGRADUATE STEM EDUCATION (IUSE:EDU) PROGRAM.? THE IUSE:EDU PROGRAM SUPPORTS RESEARCH AND DEVELOPMENT PROJECTS TO IMPROVE THE EFFECTIVENESS OF STEM EDUCATION FOR ALL STUDENTS. SUPPORT IS ALSO PROVIDED BY THE DIRECTORATE FOR TECHNOLOGY, INNOVATIONS AND PARTNERSHIPS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

HIGHER EDUCATION EMERGENCY RELIEF FUND - BRYN MAWR COLLEGE

HIGHER EDUCATION EMERGENCY RELIEF FUND - BRYN MAWR COLLEGE

COLLABORATIVE: RUI: BEE: C-EVO: LINKING CARBON CYCLING TO ECO-EVOLUTIONARY RESPONSES OF A FOUNDATIONAL PLANT TO GLOBAL CHANGE

BUILDING STEM IDENTITY AND PERSISTENCE THROUGH STEM PATHWAY MENTORSHIP

FIRST IN THE WORLD

NOYCE TEACHER SCHOLARSHIP PROGRAM AT BRYN MAWR AND HAVERFORD COLLEGES

INTERACTIVE TRANSFER FOR CONTINUAL LIFELONG LEARNING

STRUCTURAL INVESTIGATION AND MANIPULATION OF KEY REGULATORY ENZYMES IN THE MEVALONATE PATHWAY OF ISOPRENOID BIOSYNTHESIS

COLLABORATIVE PROPOSAL: "THE EDGE PROGRAM"

CAREER: THE BRYN MAWR PLASMA LABORATORY---A LIBERAL-ARTS CENTERED FACILITY FOR BASIC PLASMA RESEARCH AND PLASMA SCIENCE EDUCATION

ENANTIOSELECTIVE DESYMMETRIZING HYDROAMINATION TO SYNTHESIZE COMPLEX ALL-CARBON QUATERNARY STEREOCENTER CONTAINING SATURATED HETEROCYCLIC STRUCTURES - PROJECT SUMMARY/ABSTRACT HETEROCYCLIC RINGS AND TETRAHEDRAL CARBONS ARE COMMON COMPONENTS OF SUCCESSFUL SMALL MOLECULE DRUGS. THE POLARITY AND HYDROGEN BONDING CAPABILITY OF HETEROCYCLIC RINGS PROMOTES SOLUBILITY IN AQUEOUS SOLUTIONS AND PROVIDES OPPORTUNITIES FOR CRITICAL INTERMOLECULAR FORCE INTERACTIONS WITH PROTEIN TARGETS, THEREBY PROMOTING DRUG-PROTEIN BINDING AFFINITY. TETRAHEDRAL CARBONS IN DRUGS CREATE SELECTIVE INTERACTIONS WITH PROTEIN TARGETS THEREBY MINIMIZING UNWANTED SIDE EFFECTS DUE TO INTERACTIONS WITH NON-TARGET PROTEINS OR OTHER BIOMOLECULES. TETRAHEDRAL CARBONS ARE ALSO BELIEVED TO FACILITATE SMALL MOLECULE DISSOLUTION BECAUSE MORE THREE-DIMENSIONAL MOLECULES PACK LESS EFFICIENTLY INTO THE SOLID PHASE AND THEREFORE MORE READILY SEPARATE. ALL-CARBON QUATERNARY CARBONS ARE ONE OF THE MOST DIFFICULT TYPES OF TETRAHEDRAL CARBONS AND ARE COMMON IN BIOACTIVE MOLECULES, ESPECIALLY THOSE FOUND IN NATURE. IN FACT, STRUCTURE SEARCHES OF FUSED HETEROCYCLIC RINGS WITH QUATERNARY CARBONS AT THE BRIDGEHEAD ARE FOUND BY THE THOUSANDS IN BIOACTIVE MOLECULES, YET THERE IS NO GENERAL SYNTHETIC TOOL TO ENANTIOSELECTIVELY CONSTRUCT THESE MOLECULES. THE CURRENT PROPOSAL DESCRIBES AN EFFICIENT SYNTHETIC TOOL TO ENANTIOSELECTIVELY CONSTRUCT FUSED HETEROCYCLIC COMPOUNDS WITH BRIDGEHEAD QUATERNARY CARBONS FROM INEXPENSIVE BENZOIC ACID DERIVATIVES IN FOUR OR FIVE STEPS. THE METHOD GENERATES SYMMETRICAL CYCLOHEXADIENE STRUCTURES FROM BIRCH REDUCTION-ALKYLATION REACTIONS OF BENZOIC ACID DERIVATIVES AND THEN DESYMMETRIZES THEM THROUGH ENANTIOSELECTIVE ALKENE HYDROAMINATION REACTIONS. THE PROPOSAL WILL EXPLORE THE USE OF CHIRAL COPPER CATALYSTS TO FACILITATE THE ENANTIOSELECTIVE DESYMMETRIZING HYDROAMINATION REACTION. COPPER HAS THE ADVANTAGE OF BOTH LOW COST AND BEING ENVIRONMENTALLY BENIGN. THE RESEARCH WOULD BUILD ON THE ENANTIOSELECTIVE DESYMMETRIZING MIZOROKI- HECK REACTIONS THAT WE HAVE PREVIOUSLY REPORTED FOR BOTH PALLADIUM AND NICKEL CHIRAL CATALYSTS. IT ALSO SEEKS TO EXTEND THE IMPRESSIVE COPPER-CATALYZED HYDROAMINATION WORK BY OTHER RESEARCHERS TO ENANTIOSELECTIVE DESYMMETRIZING REACTIONS. CRITICAL TO THE REACTION DEVELOPMENT WILL BE THE USE OF COMPUTATIONAL CHEMISTRY TO MODEL THE KEY AMINO- CUPRATION STEP, WHICH IS THE LIKELY RATE AND ENANTIOSELECTIVITY DETERMINING STEP BASED ON LITERATURE PRECEDENT. LEVERAGING OUR EXPERIENCE WITH UNDERSTANDING THE BASIS OF ENANTIOSELECTIVITY IN THE ANALOGOUS 1,2-INSERTION OF THE DESYMMETRIZING NI-CATALYZED MIZOROKI-HECK REACTION, WE WILL ACCELERATE THE SEARCH FOR OPTIMAL CHIRAL LIGANDS BY MODELING THE KEY AMINO-CUPRATION STEP. MOST IMPORTANTLY, THE PROJECT WILL PROVIDE THREE UNDERGRADUATE STUDENTS AND ONE GRADUATE STUDENT WITH EXPOSURE TO AND TRAINING IN CONTEMPORARY SYNTHETIC CHEMISTRY REACTION DEVELOPMENT TO ADDRESS AN IMPORTANT DEFICIENCY IN THE ARMAMENTARIUM OF SYNTHETIC TOOLS FOR COMPLEX MOLECULE SYNTHESIS IN THE 21ST CENTURY.

BIOPHYSICAL INVESTIGATION OF BACTERIAL LIPID TRAFFICKING PROTEINS FOR NOVEL ANTIBIOTIC DEVELOPMENT - PROJECT SUMMARY/ABSTRACT GRAM-NEGATIVE BACTERIA, LIKE ESCHERICHIA COLI, GREATLY CONTRIBUTE TO THE ONGOING CRISIS OF ANTIMICROBIAL-RESISTANT INFECTIONS, WHICH IMPACT MILLIONS ANNUALLY. THESE BACTERIA HAVE A UNIQUE CELLULAR ARCHITECTURE AS THEY ARE SURROUNDED BY A DOUBLE MEMBRANE BARRIER. THE EFFICIENT FLUX OF LIPIDS BETWEEN THESE MEMBRANES IS REQUIRED FOR BACTERIAL GROWTH AND SURVIVAL; TWO CONSERVED MAMMALIAN CELL ENTRY (MCE) PROTEIN FAMILY MEMBERS HAVE BEEN IMPLICATED IN FACILITATING THIS TRANSLOCATION. THIS WORK WILL INVESTIGATE THE FUNCTIONAL MECHANISMS OF THESE MCE- PROTEINS, AS THEY ARE UNREALIZED TARGETS OF NOVEL ANTIBIOTIC DEVELOPMENT. WE WILL UTILIZE AN IN VITRO RECONSTITUTION ASSAY TO RECONSTRUCT THE LIPID-TRAFFICKING FUNCTION OF THESE PROTEINS USING SYNTHETIC MEMBRANE MIMETICS TO BETTER UNDERSTAND SUBSTRATE SPECIFICITY, LIPID TRANSLOCATION RATES, AND HOW INCLUSION OF MCE-PROTEIN BINDING PARTNERS AFFECTS ACTIVITY (SPECIFIC AIM 1). THESE EXPERIMENTS WILL BE COMPLEMENTED BY A THOROUGH INVESTIGATION OF MCE- PROTEIN MEMBRANE BINDING, WHICH WILL BE INTERROGATED USING A NOVEL MICROSCOPY-BASED ASSAY (SPECIFIC AIM 2). TOGETHER, THESE AIMS WILL IDENTIFY INTEGRAL PROTEIN REGIONS FOR FUNCTION, ALONG WITH CRITICAL PROTEIN-PROTEIN AND MEMBRANE-PROTEIN INTERFACES FOR POTENTIAL DRUG TARGETING. FINALLY, WE WILL CONSTRUCT THE FIRST COMPUTATIONAL MODEL OF MCE-MEDIATED LIPID TRAFFICKING AND VALIDATE THIS MODEL EXTENSIVELY WITH REPRODUCTION OF GENETIC EXPERIMENTS (SPECIFIC AIM 3). THIS MODEL WILL BE FUNDAMENTAL IN UNDERSTANDING HOW NEWLY DESIGNED DRUGS WILL AFFECT THE ACCUMULATION AND DEPLETION OF LIPIDS UNDER VARIOUS CONDITIONS AND WILL PREDICT HOW TO BEST TARGET LIPID TRAFFICKING FOR BACTERIAL DEATH. THESE AIMS WILL BE PRIMARILY COMPLETED BY UNDERGRADUATE STUDENT-SCIENTISTS, DIRECTLY PROVIDING THEM WITH TRANSFORMATIVE INDEPENDENT RESEARCH EXPERIENCES WHICH WILL FURTHER THEIR TECHNICAL, ANALYTICAL, AND COMMUNICATION SKILLS IN PREPARATION FOR THEIR FUTURE CAREERS IN THE BIOMEDICAL SCIENCES. THIS WORK SEAMLESSLY COMBINES BIOPHYSICAL CHARACTERIZATION OF LIPID TRAFFICKING PROTEINS WITH COMPUTATIONAL SIMULATIONS TO PROVIDE A THREE-FOLD APPROACH FOR THE IDENTIFICATION OF NOVEL ANTIBIOTIC TARGETS. ACCORDINGLY, THESE AIMS DIRECTLY ADDRESS THE VOIDS IN OUR CURRENT UNDERSTANDING OF THE MECHANISMS OF BACTERIAL LIPID TRAFFICKING AND THE ROLE OF MCE-PROTEINS IN THIS CRITICALLY IMPORTANT PROCESS, WHILE PROVIDING SEVERAL UNIQUE AVENUES FOR ANTIBIOTIC DRUG DEVELOPMENT.

CAREER: MAGNETIC BUBBLE DYNAMICS IN NANODISKS WITH PERPENDICULAR MAGNETIC ANISOTROPY

MOLYBDENUM PTERIN-DITHIOLENE COMPLEXES FOR MODEL STUDIES OF THE CATALYTIC SITE OF

STUDY OF FAST MAGNETIZED TURBULENT PLASMA FLOW PAST OBSTACLES IN A WIND-TUNNEL LABORATORY EXPERIMENT -TURBULENCE CAN BE FOUND IN SYSTEMS WITH FLUIDS FLOWING PAST OR AROUND OBJECTS EMBEDDED WITHIN THAT FLOW. THIS IS TRUE OF CONVENTIONAL FLUIDS SUCH AS LIQUIDS LIKE WATER OR GASES LIKE AIR, AND IS ALSO TRUE OF PLASMAS. THIS AWARD SUPPORTS A STUDY OF THE IMPACT DIFFERENT TYPES OF OBSTACLES MAKE ON TURBULENT, MAGNETIZED PLASMA FLOW IN A TUNNEL VACUUM CHAMBER. SINCE PLASMA CAN INTERACT WITH ELECTRIC AND MAGNETIC FIELDS, THE TARGETS IN THESE EXPERIMENTS CAN BE BOTH SOLID OBJECTS MADE OF MATERIAL SUCH AS CERAMIC, OR MAGNETIC FIELD STRUCTURES GENERATED EITHER BY PERMANENT MAGNETS OR BY DRIVING CURRENT THROUGH WIRES CROSSING THE CHAMBER. INTERPRETATION OF MEASUREMENTS MADE IN THESE EXPERIMENTS CAN BE USED TO HELP BETTER UNDERSTAND NATURALLY OCCURRING INSTANCES OF MAGNETIZED PLASMA FLOWING PAST OBSTACLES. A PRIME EXAMPLE OF SUCH PLASMA IS THE SOLAR WIND FLOWING BY BOTH NON-MAGNETIC OBJECTS LIKE THE MOON AND MAGNETIC OBSTACLES LIKE THE EARTH?S MAGNETOSPHERE, WHERE THE NEW UNDERSTANDING CAN CONTRIBUTE TO SPACE WEATHER PREDICTION BOTH HERE ON EARTH AND ON OTHER PLANETS. THIS WORK CAN ALSO BE IMPORTANT FOR BETTER CHARACTERIZATION OF THE PLASMA FLOW INTERACTIONS WITH POTENTIALLY VULNERABLE HUMAN-MADE OBJECTS SUCH AS SPACECRAFT OR SATELLITE CONSTELLATIONS. THE PROJECT WILL ALSO HAVE AN IMPORTANT WORKFORCE DEVELOPMENT COMPONENT IN ENGAGING AND TRAINING THE NEXT GENERATION OF PLASMA SCIENTISTS AT BOTH GRADUATE AND UNDERGRADUATE LEVEL TO CONTRIBUTE TO THE US NATIONAL SECURITY AND ECONOMIC PROSPERITY IN THEIR FUTURE CAREERS. THIS AWARD SUPPORTS AN EXPERIMENT WITH A COAXIAL PLASMA GUN LAUNCHING A TURBULENT MAGNETIZED PLASMA AT HIGH SPEEDS DOWN A 0.25M WIDE, 2.5M LONG CYLINDRICAL VACUUM CHAMBER. THE EXPERIMENTAL PLASMA AND FLOW PARAMETERS WILL BE VARIED FROM LOW-TO-HIGH BETA VALUES AS WELL AS FROM SUB-TO-SUPER ALFVENIC OR MACH NUMBERS. EMBEDDED WITHIN THIS FLOW WILL BE OBSTACLES WHICH CAN INTERACT WITH AND MODIFY THE FLOWING PLASMA AS WELL AS AFFECT THE CHARACTERISTICS OF THE OBSERVED TURBULENCE WITHIN THE PLASMA. THESE OBSTACLES CAN BE SOLID OBJECTS MADE OF EITHER INSULATING NON-MAGNETIC MATERIALS SUCH AS CERAMIC OR CONDUCTING NON-MAGNETIC MATERIALS SUCH AS COPPER; OR MAGNETIC FIELD CONFIGURATIONS INCLUDING AXIAL FIELD GENERATED BY PULSED CURRENT IN A STRAIGHT WIRE TRAVERSING THE DIAMETER OF THE CHAMBER OR DIPOLE FIELDS PRODUCED BY PULSED CURRENT THROUGH WIRE COILS OR WITH STRONG PERMANENT MAGNETS. DIFFERENCES IN THE RESULTING TURBULENCE CHARACTERISTICS WILL BE EXPLORED VIA SEVERAL ANALYSIS TECHNIQUES INCLUDING SPECTRAL DECOMPOSITION, CORRELATION, AND INTERMITTENCY ANALYSIS. MEASUREMENTS WILL BE MADE USING INSERTED PROBES AS WELL AS VIA NON-INVASIVE SPECTROSCOPIC METHODS, WITH COMPARISONS TO NATURALLY OCCURRING PLASMA FLOW OBSTACLE ENCOUNTERS SUCH AS BOW SHOCKS, MAGNETOTAILS, OR DEPLETION WAKES TO BE PURSUED WITHIN THE EXPERIMENTAL SYSTEM. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

REGULATION OF STREPTOMYCES DIFFERENTIATION AND ANTIBIOTIC PRODUCTION BY SOXR

BRC-BIO: NEURAL MECHANISMS UNDERLYING STABLE FLIGHT IN INSECTS -ANIMALS REQUIRE INPUT FROM THEIR SENSES TO ACHIEVE ACCURATE MOVEMENTS, SUCH AS STABLE WALKING ON ROUGH TERRAIN OR GRASPING AN OBJECT WITH APPROPRIATE STRENGTH. THIS SENSORY FEEDBACK MUST BE BOTH FAST AND ACCURATE TO EFFECTIVELY GUIDE BEHAVIORS, AND IT IS PARTICULARLY NECESSARY IN COMPLEX AND CHANGING ENVIRONMENTS. PERHAPS NO BEHAVIOR IS MORE DEMANDING OF SENSORY FEEDBACK THAN FLIGHT. FOR EXAMPLE, AN INSECT MUST MAKE RAPID ADJUSTMENTS IN FLIGHT TO A SMALL GUST OF WIND. DUE TO INSECTS? SMALL BODY SIZE RELATIVE TO OTHER FLYING ANIMALS, SENSORY PROCESSING MUST BE ACHIEVED IN SMALL NEURAL CIRCUITS COMPRISED OF FEW NEURONS. INSECT FLIGHT THEREFORE PRESENTS UNIQUE OPPORTUNITIES NOT ONLY TO ENRICH OUR UNDERSTANDING OF HOW SENSORY FEEDBACK GUIDES BEHAVIOR, BUT ALSO TO UNCOVER GENERAL STRATEGIES FOR FAST AND EFFICIENT INFORMATION PROCESSING THAT CAN INFORM THE DEVELOPMENT OF NEW BIO-INSPIRED SENSING TECHNOLOGIES. THIS PROJECT WILL INVESTIGATE SENSORY SIGNALS THAT CONVEY INFORMATION ABOUT WING BENDING DURING FLIGHT AND HOW THESE SIGNALS ARE USED TO GUIDE FLIGHT BEHAVIORS. EXPERIMENTS WILL EXAMINE FLIGHT BEHAVIORS AND NEURAL RESPONSES, AND SIMULATIONS WILL BE USED TO EXAMINE HOW INCOMING SENSORY INFORMATION MIGHT BE TRANSFORMED INTO BEHAVIORAL RESPONSES. THIS PROJECT WILL SUPPORT THE DEVELOPMENT OF A WORKSHOP SERIES, INCLUDING PUBLICLY ACCESSIBLE TRAINING MATERIALS, IN MODERN DATA ANALYSIS AND VISUALIZATION METHODS FOR UNDERGRADUATES CONDUCTING SCIENTIFIC RESEARCH. MECHANOSENSORY FEEDBACK OPERATES WITH REMARKABLE SPEED AND SENSITIVITY TO SMALL PERTURBATIONS, MAKING IT ESPECIALLY CRITICAL FOR GUIDING RAPID MOVEMENTS. PREVIOUS EXPERIMENTS HAVE SHOWN THAT PERTURBATIONS TO INSECT WINGS INDUCE COMPENSATORY STABILIZING BEHAVIORS, DEMONSTRATING THAT FEEDBACK FROM THE WINGS IS DIRECTLY INVOLVED IN BEHAVIORAL CONTROL. HOWEVER, THE SENSORY SIGNALS MEDIATING THIS BEHAVIOR REMAIN POORLY UNDERSTOOD. THIS WORK WILL CHARACTERIZE NEURAL AND BEHAVIORAL RESPONSES TO DESTABILIZING PERTURBATIONS AND WILL EXAMINE COMPUTATIONS THAT TRANSFORM SENSORY INPUT TO BEHAVIORS. THE FIRST AIM WILL QUANTIFY BEHAVIORAL RESPONSES TO PERTURBATIONS, SUCH AS WIND GUSTS AND COLLISIONS, IN A TETHERED FLIGHT PREPARATION USING HIGH SPEED 3D VIDEOGRAPHY. THE SECOND AIM WILL IDENTIFY HOW THESE PERTURBATIONS ARE ENCODED BY NEURONS, USING EXTRACELLULAR ELECTROPHYSIOLOGY TO DIRECTLY RECORD FROM PRIMARY SENSORY NEURONS. IN THE THIRD AIM, COMPUTATIONAL METHODS WILL BE USED TO IDENTIFY PLAUSIBLE CIRCUIT COMPUTATIONS THAT ARE CONSISTENT WITH OBSERVED BEHAVIORS. A FOCUS ON THIS SMALL AND WELL-DEFINED NEURAL POPULATION PROVIDES EXCEPTIONAL OPPORTUNITIES TO UNDERSTAND NEURAL FUNCTION ACROSS MULTIPLE STAGES OF PROCESSING, FROM SENSING TO MOTOR OUTPUT, AND DIRECTLY LINK NEURAL ACTIVITY TO ANIMAL BEHAVIOR. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

ELUCIDATING AND HARNESSING THE MOLECULAR MECHANISMS OF PROTECTIVE CLEARANCE IN ENDOGENOUS AND ENGINEERED PHAGOCYTES - PROJECT SUMMARY/ABSTRACT PROTECTIVE CLEARANCE DESCRIBES THE PROCESS OF THE REMOVAL OF MEMBRANE-INTACT CELLS OR PARTS OF CELLS WITHOUT INDUCTION OF PRO-INFLAMMATORY RESPONSES; IT IS A CENTRAL MODE OF NORMAL DEVELOPMENT AND HOMEOSTASIS ACROSS TISSUES AND PHYLA. EXECUTING THIS PROCESS IN A REGULATED AND ANTI-INFLAMMATORY FASHION REQUIRES EXQUISITE ORCHESTRATION OF A COLLECTION OF ACTIVITIES INCLUDING RECEPTOR-MEDIATED PHAGOCYTOSIS, LYSOSOME FORMATION, AND INTRACELLULAR DEGRADATION. PROTECTIVE CLEARANCE PLAYS A PARTICULARLY IMPORTANT ROLE IN MAINTAINING FUNCTION AND HOMEOSTASIS IN THE CENTRAL NERVOUS SYSTEM (CNS). THE LYSOSOMAL STORAGE DISORDERS ARE A BROAD FAMILY OF DISEASES CHARACTERIZED BY DYSREGULATED PROTECTIVE CLEARANCE IN THE CNS. BATTEN DISEASE IS A CLASS OF 13 FATAL NEURODEGENERATIVE LYSOSOMAL STORAGE DISORDERS THAT USUALLY APPEAR IN CHILDHOOD AND COMPRISE THE MOST COMMON INHERITED PEDIATRIC NEURODEGENERATIVE DISEASE WORLDWIDE. THE PATHOLOGY OF BATTEN DISEASE IS LINKED TO SYNAPTIC DYSFUNCTION AND AUTO ANTIBODY DEPOSITION IN THE CNS. ALL GENETICALLY MAPPED FORMS OF THE DISEASE ARE MONOGENIC, CAUSED BY MUTATIONS IN ONE OF 13 CEROID LIPOFUSCINOSIS (CLN) GENES. DESPITE THE SUCCESS MAPPING THE CLN GENES, THE CELL BIOLOGICAL MECHANISMS GOVERNING THE CLN PROTEINS IN SPACE AND TIME REMAIN AN OPEN PROBLEM. FURTHER UNDERSTANDING OF THE FUNDAMENTAL MECHANISMS UNDERLYING CLN PROTEIN FUNCTION MAY IDENTIFY NEW AVENUES TO TREAT BATTEN DISEASE. THE GOAL OF THIS PROPOSAL IS TO ELUCIDATE THE MOLECULAR AND CELLULAR MECHANISMS UNDERLYING PROTECTIVE CLEARANCE IN ENDOGENOUS PHAGOCYTES AND ENGINEER THE PROCESS IN FOR THERAPY BY PROGRAMMING PHAGOCYTES TO ELIMINATE AUTO ANTIGEN-ANTIBODY COMPLEXES IN THE CNS IN AN ANTI-INFLAMMATORY MANNER. THIS PROJECT WILL USE THREE POWERFUL MODEL SYSTEMS COMPRISED OF LIVING PHAGOCYTES AND DEFINED TARGETS TO DEFINE THE MOLECULAR AND CELLULAR MECHANISMS UNDERLYING PROTECTIVE CLEARANCE. IN AIM 1, WE WILL USE A SIMPLIFIED CELL MODEL OF PROTECTIVE CLEARANCE TO EXPLORE A CONNECTION WE RECENTLY DISCOVERED BETWEEN A CLN PROTEIN AND A CONSERVED PHAGOCYTE RECEPTOR. IN AIM 2, WE WILL USE A NOVEL MODEL OF ENDOGENOUS PROTECTIVE CLEARANCE IN THE RETINA TO SYSTEMATICALLY DEFINE THE FUNCTIONS OF EACH CLN PROTEIN DURING PROTECTIVE CLEARANCE. IN AIM 3, WE WILL USE OUR EXPERTISE IN IMMUNE CELL PROGRAMMING TO ENGINEER PHAGOCYTES THAT ELIMINATE ANTIGEN-ANTIBODY COMPLEXES FROM THE CNS VIA PROTECTIVE CLEARANCE AND TEST THESE MOLECULES IN VIVO IN AN ADVANCED MOUSE CNS MACROPHAGE TRANSPLANT MODEL. COMPLETION OF THESE AIMS WILL CLARIFY MOLECULAR MECHANISMS UNDERLYING PROTECTIVE CLEARANCE, DEFINE HOW BATTEN DISEASE MUTATIONS DYSREGULATE THE PROCESS, AND INVESTIGATE THE THERAPEUTIC POTENTIAL OF SYNTHETIC RECEPTORS TO ELIMINATE ANTIGEN-ANTIBODY COMPLEXES FROM THE CNS IN AN ANTI-INFLAMMATORY MANNER.

COLLABORATIVE RESEARCH: QUANTUM DYNAMICS AND CONTROL WITH ULTRACOLD RYDBERG ATOMS

RUI: MECHANISMS THAT INFLUENCE DNA METHYLATION MAINTENANCE AT IMPRINTED GENES IN MOUSE

RUI: INVESTIGATION OF PHOSPHOLIPID TRAFFICKING BY BACTERIAL MEMBRANE PROTEINS -THIS RESEARCH FOCUSES ON UNDERSTANDING THE MOLECULAR DETAILS OF HOW BACTERIA MAINTAIN THE SELECTIVE PERMEABILITY OF THEIR MEMBRANES, WHICH IS ESSENTIAL TO SUPPORT LIFE, DURING GROWTH. SUCH INFORMATION CAN INFORM THE DEVELOPMENT OF NOVEL STRATEGIES TO HELP COMBAT BACTERIAL INFECTIONS. MILLIONS OF ANTIBIOTIC-RESISTANT INFECTIONS OCCUR EACH YEAR, REQUIRING THE CONSTANT DEVELOPMENT OF NEW DRUGS TO TREAT THESE AND EFFECTIVELY KILL THE BACTERIA CAUSING THEM. THIS WORK WILL ENGAGE THE STUDENT-SCIENTISTS OF BRYN MAWR COLLEGE IN GROUNDBREAKING RESEARCH AT THE INTERFACE OF BIOCHEMISTRY, BIOLOGY, AND MOLECULAR BIOPHYSICS IN BOTH RESEARCH AND ACADEMIC TEACHING LABS. OUTREACH PARTNERSHIP WORK WITH THE FRANKLIN INSTITUTE OF PHILADELPHIA WILL EXTEND THE IMPACT OF THIS WORK INTO THE GREATER COMMUNITY. THIS PROJECT AIMS TO UNDERSTAND THE ROLE OF BACTERIAL MEMBRANE PROTEINS IN THE BIOGENESIS PATHWAY OF PHOSPHOLIPIDS, A REQUIRED PROCESS FOR THE GROWTH AND PROLIFERATION OF GRAM-NEGATIVE BACTERIA. THIS WORK WILL UTILIZE A COMPLEMENTARY ARRAY OF EXPERIMENTAL TECHNIQUES, INCLUDING IN VITRO RECONSTITUTION OF THE LIPID TRAFFICKING PATHWAY AND QUANTIFICATION OF LIPID FLUX BETWEEN SYNTHETIC VESICLES ? THIS NOVEL APPROACH CREATES A PLATFORM FOR THE SYSTEMATIC INVESTIGATION OF EXPERIMENTAL CONDITIONS ON LIPID TRAFFICKING. ADDITIONAL TECHNIQUES WILL INCLUDE TRADITIONAL BIOCHEMICAL ANALYSES OF MEMBRANE PROTEINS, MUTAGENESIS AND CHARACTERIZATION OF PROTEIN VARIANTS, MOLECULAR DYNAMICS SIMULATIONS, AND SINGLE PARTICLE CRYO-ELECTRON MICROSCOPY (EM). TOGETHER, THESE EXPERIMENTS WILL DIRECTLY FILL A VOID IN OUR CURRENT UNDERSTANDING OF THE BIOGENESIS OF MACROMOLECULES REQUIRED FOR BACTERIAL SURVIVAL. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

THE ENANTIOSELECTIVE SYNTHESIS OF NEW PHENANTHRIDINONE AND CARBAZOLE ANALOGS WITH QUATERNARY AND TERTIARY CARBONS USING THE BIRCH-HECK SEQUENCE

COLLABORATIVE RESEARCH: THE EFFECTS OF DZYALOSHINSKII MORIYA INTERACTIONS ON MAGNETIZATION DYNAMICS IN LAYERED THIN FILMS

AGE EFFECTS ON EPISODIC MEMORY: NEUROPSYCHOLOGY, ELECTROPHYSIOLOGY, AND MODELING

COLLABORATIVE RESEARCH: COLD RYDBERG ATOMS

COLLABORATIVE - CS1: CREATIVE COMPUTATION IN THE CONTEXT OF ART AND VISUAL MEDIA

MCA: RUI: INVESTIGATING THE ROLE OF MICROBIALITES IN LOWER-MIDDLE ORDOVICIAN REEFS OF LAURENTIA: INTEGRATING OUTCROP, PETROGRAPHIC, AND GEOCHEMICAL APPROACHES. -CORAL REEFS ARE DECLINING RAPIDLY DUE TO RISING SEAWATER TEMPERATURES AND OCEAN ACIDIFICATION. THESE ECONOMICALLY AND ECOLOGICALLY IMPORTANT HARD REEF STRUCTURES WILL SOON BE REPLACED BY SOFTER ASSEMBLAGES OF MICROBES, ALGAE, AND SPONGES. THE FOSSIL RECORD OF REEFS CAN PROVIDE CRITICAL INSIGHTS THAT ALLOW FOR PREDICTIONS ABOUT HOW REEF ENVIRONMENTS TRANSITION AWAY FROM MICROBIAL-ALGAL-SPONGE STRUCTURES TO ROBUST REEFS BUILT BY SKELETONIZED ANIMALS LIKE CORALS. THIS PROJECT WILL INVESTIGATE SUCH A TRANSITION DURING THE ORDOVICIAN PERIOD BY QUANTIFYING TRENDS IN REEF-BUILDERS THROUGH TIME. THE ECOLOGIC IMPACT OF THE FOSSIL REEFS WILL BE COMPARED TO THAT OF MODERN CORAL REEFS TO HELP MAKE PREDICTIONS ABOUT HOW MODERN REEF ENVIRONMENTS WILL FUNCTION WITHOUT ROBUSTLY-SKELETONIZED REEF-BUILDERS. THE PRODUCTS OF THIS WORK WILL GREATLY ADVANCE THE CAREER OF TWO LATINX GEOSCIENTISTS WHO TEACH AT PREDOMINANTLY UNDERGRADUATE INSTITUTIONS. THIS WORK WILL EXPOSE NINETY FIRST-GENERATION, LOW-INCOME (FGLI) STUDENTS TO THE STUDY OF REEFS AND WILL INVOLVE SIX TO TWELVE FGLI STUDENTS IN MENTORED RESEARCH EXPERIENCES. THIS PROJECT WILL QUANTIFY FRAMEWORK BUILDERS IN REEFS OF THE EARLY-MIDDLE ORDOVICIAN SUCCESSION NEAR IBEX, UTAH USING A COMBINATION OF OUTCROP, PETROGRAPHIC, AND GEOCHEMICAL TECHNIQUES. A SPECIFIC AIM OF THIS WORK IS TO DEVELOP GEOCHEMICAL TECHNIQUES FOR UNCOVERING THE PRESENCE OF CRYPTIC MICROBIALITE FABRICS, PARTICULARLY IN MUD-MOUNDS. ANOTHER AIM IS TO DETAIL HOW THE COMBINED REEF MOUNDS WITHIN A GIVEN INTERVAL ACT AS A LARGER REEF UNIT WITH RESPECT TO IMPACTS ON THE DEPOSITIONAL SYSTEM. THIS WORK WILL INCLUDE SUMMER FIELD AND LABORATORY RESEARCH CONDUCTED BY FGLI UNDERGRADUATES PARTICIPATING IN TWO PROGRAMS AT BRYN MAWR COLLEGE: THE STEM POSSE AND STEMLA FELLOWS PROGRAMS. EACH SUMMER, RESEARCH MENTEES WILL WORK WITH THE PI TO PRESENT SHORT COURSES ON THE STUDY OF FOSSIL REEFS TO INCOMING COHORTS OF THE TWO PROGRAMS. THE PROJECT WILL INVOLVE A FIELD RESEARCH TRIP TO THE FLORIDA KEYS TO COMPARE ORDOVICIAN FOSSIL REEF DATA TO THE FLORIDA CORAL REEF SYSTEM. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

COLLABORATIVE RESEARCH: COHERENT CONTROL OF INTERACTIONS AMONG ULTRACOLD RYDBERG ATOMS

RUI: ANALYSIS OF CHROMATIN-LEVEL MECHANISMS REGULATING GENOMIC IMPRINTING IN MOUSE

RUI: SPECIFICATION AND EVOLUTION OF REPRODUCTIVE FATE IN THE PEA APHID

SHF: MEDIUM: COLLABORATIVE RESEARCH: THE THEORY AND PRACTICE OF DEPENDENT TYPES IN HASKELL

PHILADELPHIA REGIONAL NOYCE PARTNERSHIP NEW TEACHER SUPPORT PROGRAM

PHILADELPHIA REGIONAL NOYCE PARTNERSHIP

ENGINEERED SAMPLES OF ULTRACOLD RYDBERG ATOMS

RUI: ANALYSIS OF EPIGENETIC MODIFICATIONS REGULATING GENOMIC IMPRINTING IN MOUSE

RUI: PATTERNING DIVERGENT DEVELOPMENT IN THE PEA APHID

RUI: FURTHER EXPANSION OF SULFONE IMINIUM REAGENTS AND THEIR USE IN FLUORINATION AND CYANATION METHODOLOGIES -WITH THE SUPPORT OF THE CHEMICAL SYNTHESIS PROGRAM IN THE DIVISION OF CHEMISTRY, PATRICK MELVIN OF BRYN MAWR COLLEGE IS STUDYING THE DEVELOPMENT OF HIGHLY REACTIVE MOLECULES CAPABLE OF INTRODUCING A FLUORINE ATOM INTO VARIOUS COMPOUNDS. FLUORINE, AN ELEMENT ON THE PERIODIC TABLE, HAS RISEN IN PROMINENCE OVER THE LAST SEVERAL DECADES, LARGELY DUE TO A HOST OF BENEFICIAL PROPERTIES THAT IT CAN IMPART ON ORGANIC MOLECULES. THIS HAS LED TO FLUORINE ATOMS BEING INTRODUCED TO MANY OF THE LEADING PHARMACEUTICALS ON THE MARKET, OFTEN IMPROVING THE ACTIVITY OF EXISTING DRUGS WHILE ALSO PAVING THE WAY FOR NEW THERAPEUTICS. GIVEN THESE IMPORTANT ENHANCEMENTS, THE MELVIN LABORATORY HAS DEVISED A NEW CLASS OF REAGENTS, CALLED SULFONE IMINIUM FLUORIDES (SIFS), WHICH ARE CAPABLE OF INCORPORATING FLUORINE IN THE MOST EFFICIENT AND EXPEDIENT WAYS POSSIBLE. RESEARCH PLANS HERE AIM TO EXPAND THE UTILITY OF SIFS TO TACKLE EVEN MORE CHALLENGING FLUORINATION REACTIONS, SUCH AS THE FORMATION OF CRITICAL PHOSPHORUS ? FLUORINE BONDS. ADDITIONALLY, DR. MELVIN IS INVESTIGATING HOW THIS REAGENT CLASS CAN BE ALTERED TO NOT ONLY IMPROVE FLUORINATION REACTIONS, BUT TO ALSO ENHANCE THE CREATION OF NITRILES, A MUCH SOUGHT-AFTER FUNCTIONAL GROUP ON MEDICINALLY RELEVANT ORGANIC MOLECULES. BEYOND THE LABORATORY, DR. MELVIN IS BRINGING HIS RESEARCH ON SULFONE IMINIUM FLUORIDES TO THE CLASSROOM IN AN UPPER-LEVEL, RESEARCH-INSPIRED LABORATORY COURSE AT BRYN MAWR COLLEGE. FINALLY, TO INCREASE CHEMISTRY ENGAGEMENT AMONGST THE ALL-FEMALE UNDERGRADUATE POPULATION, DR. MELVIN IS DEVELOPING A WEEK-LONG ?NOBEL PRIZE-WINNING CHEMISTRY TUTORIAL?, WHICH OFFERS STUDENTS A CHANCE TO ACTIVELY CONNECT WITH CURRENT, CUTTING-EDGE SCIENCE. IN THIS RESEARCH, PATRICK MELVIN OF BRYN MAWR COLLEGE IS FURTHER PROBING THE INFLUENCE OF SULFONE IMINIUM FLUORIDES (SIFS) ON VARIOUS ORGANIC METHODOLOGIES. RECENTLY, THE MELVIN LABORATORY HAS DEVELOPED A HIGHLY REACTIVE CLASS OF SIFS AND DEMONSTRATED THEIR REMARKABLE PROPENSITY FOR THE DEOXYFLUORINATION OF ALCOHOL AND CARBOXYLIC ACIDS AND THEIR ENGAGEMENT IN SULFUR FLUORIDE EXCHANGE (SUFEX) CHEMISTRY. THE ENHANCED REACTIVITY OF SIFS LEADS TO RAPID AND EFFICIENT TRANSFORMATIONS FOR REACTIONS THAT HAVE TRADITIONALLY BEEN CHALLENGING AND SLOW. USING THESE REAGENTS, THE MELVIN LABORATORY IS INVESTIGATING THEIR EFFECTIVENESS ON THE SYNTHESIS OF HETEROATOM ? FLUORINE BONDS, NAMELY PHOSPHORUS-FLUORINE AND SULFUR-FLUORINE BONDS, WHICH HAVE A GROWING IMPORTANCE IN BOTH MEDICINAL AND SYNTHETIC CHEMISTRY. FURTHERMORE, CLASSIC DEOXYFLUORINATION REACTIONS OF CARBONYL FUNCTIONAL GROUPS WILL BE EXAMINED USING THESE REAGENTS WITH AN EYE TOWARD CIRCUMVENTING THE NEED FOR REACTIVE FLUORIDE SOURCES. EFFORTS ARE ONGOING TO MODIFY THE SIF STRUCTURE TO ENABLE EXTERNAL BASE-FREE DEOXYFLUORINATION REACTIONS, WHICH WOULD FURTHER ELEVATE THE UTILITY OF THIS METHODOLOGY. FINALLY, THE MELVIN LABORATORY IS EXPLORING MORE EXTENSIVE ALTERATIONS TO THE SULFONE IMINIUM CORE STRUCTURE TO EMPLOY THIS REAGENT CLASS IN CYANATION REACTIONS VIA NUCLEOPHILIC AND ELECTROPHILIC PATHWAYS. THIS RESEARCH DEMONSTRATES THAT FLUORINATION METHODOLOGIES CAN BE SIGNIFICANTLY IMPROVED THROUGH CAREFUL REAGENT DESIGN AND SHOWS REAL PROMISE FOR DEVELOPING NEW PATHWAYS TO THE INSTALLATION OF IMPORTANT ORGANIC FUNCTIONALITY; MOST NOTABLY VIA THE CRAFTING OF C-F AND C-CN BONDS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

400 MHZ NMR ACQUISITION

COLLEGE WOMEN: DOCUMENTING THE STUDENT EXPERIENCE AT THE SEVEN SISTERS COLLEGES

PERSONAL ROBOTS FOR CS1: NEXT STEPS FOR AN ENGAGING PEDAGOGICAL FRAMEWORK

LEAPS-MPS: INVESTIGATION OF MONOMIAL IDEALS AND PARKING FUNCTIONS -SOLVING POLYNOMIAL EQUATIONS WITH MULTIPLE VARIABLES IS A COMMON PROBLEM ACROSS THE SCIENCES, WITH APPLICATIONS RANGING FROM ROBOTICS TO MATHEMATICAL BIOLOGY. IN THIS PROJECT, THE PI WILL EXAMINE SUCH PROBLEMS IN THE REALM OF COMMUTATIVE ALGEBRA THROUGH THE STUDY OF MINIMAL FREE RESOLUTIONS OF IDEALS IN A POLYNOMIAL RING. SPECIFICALLY, THE PI WILL FOCUS ON MONOMIAL IDEALS, WHICH ARE KEY TO UNDERSTANDING THE STRUCTURE OF ANY IDEAL, A CENTRAL TOPIC IN COMMUTATIVE ALGEBRA AND ALGEBRAIC GEOMETRY. THE SECOND PART OF THIS PROJECT IS THE STUDY OF PARKING FUNCTIONS, A CONCEPT ORIGINATING IN COMPUTER SCIENCE. THE PI WILL EXAMINE TWO NOVEL VARIATIONS OF PARKING FUNCTIONS: STIRLING PERMUTATIONS AND TIERED PARKING FUNCTIONS. THE LAST PART OF THIS PROJECT IS THE PI?S ONGOING WORK MEET A MATHEMATICIAN, A VIDEO SERIES AIMED AT BROADENING THE PARTICIPATION OF HISTORICALLY EXCLUDED AND UNDERREPRESENTED GROUPS IN THE MATHEMATICAL SCIENCES. THE PI?S WORK ON MONOMIAL IDEALS WILL FOCUS ON THEIR ALGEBRAIC INVARIANTS THAT ARISE FROM MINIMAL FREE RESOLUTIONS. SPECIFICALLY, THE PI WILL INVESTIGATE ALGEBRAIC INVARIANTS OF MONOMIAL IDEALS ASSOCIATED TO GRAPHS AND EXPRESS THESE INVARIANTS IN TERMS OF COMBINATORIAL DATA OF GRAPHS. THE PI?S WORK ON PARKING FUNCTIONS WILL FOCUS ON DEVELOPING A FRAMEWORK TO STUDY STIRLING PERMUTATIONS AND TIERED PARKING FUNCTIONS. A SPECIAL FOCUS WILL BE GIVEN TO THE ENUMERATION OF THESE PARKING FUNCTIONS AND THE GEOMETRY OF THEIR ASSOCIATED POLYTOPES. LASTLY, THE PI WILL WORK ON INITIATIVES RELATED TO MEET A MATHEMATICIAN,? WITH THE GOAL OF BROADENING PARTICIPATION IN THE MATHEMATICAL SCIENCES FROM LOCAL TO INTERNATIONAL LEVELS. SPECIFICALLY, THE PI WILL CONTINUE THE MEET A MATHEMATICIAN? VIDEO SERIES, ORGANIZE AN ANNUAL INCLUSIVE MATH CONFERENCE AT BRYN MAWR COLLEGE FOR STUDENTS IN THE PHILADELPHIA AREA, AND HOST STORYTELLING EVENTS AT NATIONAL MATH CONFERENCES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

MRI: ACQUISITION OF A UHV MULTI-SOURCE SPUTTERING SYSTEM FOR MULTIDISCIPLINARY MATERIAL RESEARCH

COLLABORATIVE RESEARCH: RUI: KNOTTING PHENOMENA IN CONTACT AND SYMPLECTIC TOPOLOGY

MULTIRESONANT SPECTROSCOPY OF LONG-RANGE STATES OF MOLECULAR HYDROGEN

SYNTHETIC TOOLS FOR NEW ANTIBIOTICS

COLLABORATIVE RESEARCH: NEW CHEMO- AND BIOSTRATIGRAPHIC FRAMEWORK FOR THE LOWER TRIASSIC OF THE WESTERN U.S.: TOWARDS A HIGH-RESOLUTION UNDERSTANDING

DISTRIBUTION AND ANALYTIC ASPECTS OF CUSP FORMS

MRI: STABLE ISOTOPE ANALYSES IN A LIBERAL ARTS COLLEGE SETTING: TEACHING AND RESEARCH OPPORTUNITIES FOR UNDERGRADUATES AND FACULTY

RUI: HARNESSING ELECTROANALYTICAL CHEMISTRY FOR THE EXPLORATION OF PHOTOCATALYTIC ELECTRON TRANSFER PROCESSES

COLLABORATIVE RESEARCH: FRAMEWORKS: AN OPEN SOURCE SOFTWARE ECOSYSTEM FOR PLASMA PHYSICS

COLLABORATIVE RESEARCH: ECOSYSTEM EVOLUTION AND SUSTAINABILITY OF NUTRIENT ENRICHED COASTAL SALTMARSHES

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP) -THE NATIONAL SCIENCE FOUNDATION (NSF) GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP) IS A HIGHLY COMPETITIVE, FEDERAL FELLOWSHIP PROGRAM. GRFP HELPS ENSURE THE VITALITY AND DIVERSITY OF THE SCIENTIFIC AND ENGINEERING WORKFORCE OF THE UNITED STATES. THE PROGRAM RECOGNIZES AND SUPPORTS OUTSTANDING GRADUATE STUDENTS WHO ARE PURSUING RESEARCH-BASED MASTER'S AND DOCTORAL DEGREES IN SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS (STEM) AND IN STEM EDUCATION. THE GRFP PROVIDES THREE YEARS OF FINANCIAL SUPPORT FOR THE GRADUATE EDUCATION OF INDIVIDUALS WHO HAVE DEMONSTRATED THEIR POTENTIAL FOR SIGNIFICANT RESEARCH ACHIEVEMENTS IN STEM AND STEM EDUCATION. THIS AWARD SUPPORTS THE NSF GRADUATE FELLOWS PURSUING GRADUATE EDUCATION AT THIS GRFP INSTITUTION. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

COLLABORATIVE RESEARCH: INTERRELATIONS BETWEEN FORELAND DEFORMATION AND FLAT-SLAB SUBDUCTION: INTEGRATED ANALYSIS OF THE SIERRAS PAMPEANAS TO CORDIL

STRING COMPACTIFICATION, GENERALIZED GEOMETRY, AND 4D PHYSICS

COLLABORATIVE RUI: QUADRILATERAL SURFACE MESHES WITH PROVABLE QUALITY GUARANTEES

AUTOMATA IN SCIENCE

COLLABORATIVE RESEARCH: ANALYSIS OF WAVE MODE CONTENT IN FULLY TURBULENT,MODERATELY COLLISIONAL PLASMA THROUGH LABORATORY EXPERIMENT AND KINETIC SIMULATION

COLLABORATIVE RUI: URANIUM-SERIES CONSTRAINTS ON MELTING IN THE JAN MAYEN REGION

ARITHMETIC MANIFOLDS, AUTOMORPHIC FORMS, EXPONENTIAL SUMS, AND L-FUNCTIONS

COLLABORATIVE RESEARCH: EAGER-NEON: USING INTRASPECIFIC TRAIT VARIATION TO UNDERSTAND PROCESSES STRUCTURING CONTINENTAL-SCALE BIODIVERSITY PATTERNS

COLLABORATIVE RESEARCH: DETERMINING THE 3D KINEMATIC EVOLUTION OF THE WYOMING LARAMIDE IMPLICATIONS FOR PROCESSES OF FORELAND DEFORMATION

INVESTIGATING THE MECHANISM BY WHICH OREXINS CONTRIBUTE TO SEX DIFFERENCES IN COGNITIVE FLEXIBILITY AFTER STRESS - PROJECT SUMMARY AND ABSTRACT STRESS-RELATED PSYCHIATRIC DISORDERS, SUCH AS POST-TRAUMATIC STRESS DISORDER (PTSD) AND DEPRESSION, ARE SERIOUS MENTAL ILLNESSES THAT OCCUR TWICE AS FREQUENTLY IN WOMEN COMPARED TO MEN. DESPITE THIS DISPARITY, WE DO NOT UNDERSTAND THE BIOLOGICAL BASIS OF THESE SEX DIFFERENCES. A KEY FEATURE OF STRESS-RELATED DISORDERS SUCH AS PTSD IS HYPERAROUSAL, WHICH CONTRIBUTES TO COGNITIVE FLEXIBILITY DEFICITS. THE NEUROPEPTIDES OREXINS, KNOWN TO PROMOTE AROUSAL AND THE STRESS RESPONSE, ARE ALTERED IN PTSD PATIENTS; INCREASED OREXIN EXPRESSION HAS BEEN REPORTED IN WOMEN COMPARED TO MEN IN POSTMORTEM CLINICAL POPULATIONS. MY PREVIOUS RESEARCH DEMONSTRATES THAT FEMALE RATS EXHIBIT HIGHER LEVELS OF OREXINS COMPARED WITH MALE RATS, CONTRIBUTING TO IMPAIRED HABITUATION TO REPEATED STRESS AND SUBSEQUENT COGNITIVE FLEXIBILITY DEFICITS. HOWEVER, THE BRAIN AREAS AND SPECIFIC RECEPTORS THAT OREXINS TARGET TO CAUSE SEX-SPECIFIC COGNITIVE DEFICITS AFTER STRESS ARE UNCLEAR. IMPORTANTLY, THE ORBITOFRONTAL CORTEX (OFC) IS KNOWN TO PLAY A ROLE IN COGNITIVE FLEXIBILITY, AND BOTH THE OREXIN 1 AND 2 RECEPTORS (OX1R AND OX2R) ARE PRESENT IN THIS BRAIN AREA. ANOTHER IMPORTANT QUESTION THAT REMAINS UNANSWERED IS THE MECHANISM BY WHICH OREXINS ARE UPREGULATED IN FEMALES COMPARED WITH MALES. THE GONADAL HORMONE ESTROGEN IS A LIKELY CANDIDATE, AS OUR PREVIOUS DATA INDICATE THAT ESTROGEN AND OREXIN LEVELS ARE POSITIVELY CORRELATED AND FEMALES IN PROESTRUS (WHEN ESTROGEN LEVELS PEAK) SHOW HIGHER OREXIN SYSTEM ACTIVITY AND COGNITIVE DEFICITS AFTER STRESS. THUS, THE PROPOSED RESEARCH AIMS TO UNDERSTAND HOW OREXINS CONTRIBUTE TO SEX-SPECIFIC COGNITIVE DEFICITS AFTER STRESS AND THE MECHANISM BEHIND SEX DIFFERENCES IN THE OREXIN SYSTEM. SPECIFICALLY, AIM 1 OF THIS PROPOSAL WILL USE A NEWLY DEVELOPED OREXIN SENSOR PAIRED WITH FIBER PHOTOMETRY TO EXAMINE REAL TIME OREXIN BINDING IN THE OFC TO UNDERSTAND HOW OREXINS LEAD TO SEX-SPECIFIC COGNITIVE DEFICITS AFTER STRESS. AIM 2 WILL EXAMINE THE MECHANISM BEHIND SEX DIFFERENCES IN THE OREXIN SYSTEM BY MANIPULATING ESTROGEN LEVELS AND ASSAYING OREXIN MEASURES AND COGNITIVELY FLEXIBILITY AFTER STRESS. WE WILL ALSO TEST WHETHER ESTROGEN EXERTS ITS ACTIONS VIA THE G PROTEIN COUPLED ESTROGEN RECEPTOR (GPER), WHICH IS HIGHLY EXPRESSED IN OREXIN NEURONS. THESE FINDINGS WILL HAVE IMMEDIATE IMPLICATIONS FOR TREATMENT, AS OREXIN ANTAGONISTS ARE CURRENTLY USED TO TREAT INSOMNIA, SO IT IS CRUCIAL WE UNDERSTAND HOW THIS NEUROPEPTIDE SYSTEM DIFFERS BETWEEN MALES AND FEMALES, AS THERE MAY BE A FUTURE NEED TO DEVELOP SEX-SPECIFIC GUIDELINES IN DOSING. MOREOVER, OREXINS REGULATE STRESS RESPONSES, FOOD INTAKE, AUTONOMIC RESPONSES, AND EMOTIONAL MEMORY AND THEREBY CONTRIBUTE TO A VARIETY OF PSYCHIATRIC SYMPTOMS. IN THIS WAY, TARGETING OREXINS MAY TREAT A BROAD RANGE OF PSYCHIATRIC SYMPTOMS IN A SEX-SPECIFIC MANNER.

EDUCATION FOR SUSTAINABILITY - PHILLY: INSPIRING STUDENT STEM ENGAGEMENT AND SUCCESS BY HARNESSING REGIONAL RESOURCES AND DEVELOPING TEACHER LEADERSHIP

COLLABORATIVE RESEARCH: NEURONAL CONTROL OF ANIMAL MOVEMENTS

GOALS AND OBJECTIVES BACKGROUND: OVER THE PAST DECADE, THE PLANETARY SCIENCE COMMUNITY HAS FOUND ABUNDANT EVIDENCE OF ANCIENT LOW-TEMPERATURE AQUEOUS

LONG-TERM EFFECTS OF FOOD STAMP RECEIPT DURING CHILDHOOD ON ADULT OUTCOMES

A VISUAL PORTFOLIO-BASED APPROACH TO CS1 USING PROCESSING

CONFERENCE: DISTRIBUTED RD--BUILDING A NATIONAL NETWORK OF ENTERPRISE RESEARCH SUPPORT FOR PRIMARILY UNDERGRADUATE INSTITUTIONS (BANNERS-PUI) -THIS WORKSHOP-BASED PROJECT AIMS TO DEVELOP A SUITE OF PRACTICAL RECOMMENDATIONS TO MITIGATE THE CHALLENGES OF GRANT SUBMISSION AT THE NATION?S APPROXIMATELY 1700 PRIMARILY UNDERGRADUATE INSTITUTIONS (PUIS) THAT GRANT 4-YEAR OR HIGHER DEGREES. BY EXAMINING IN-DEPTH THE ROLES OF CAMPUS ADMINISTRATIONS, PROFESSIONAL ORGANIZATIONS, AND INFORMAL NETWORKS THAT CONTRIBUTE TO THIS PROCESS, THE PROJECT IS UNIQUELY POSITIONED TO IDENTIFY BARRIERS AND SOLUTIONS. A PILOT STUDY INDICATES THAT A FEW STAFF IN EACH GRANT-ACTIVE PUI PERFORM THE SAME CORE RESEARCH DEVELOPMENT (RD) FUNCTIONS AS A MUCH LARGER AND MORE SPECIALIZED RD STAFF AT LARGE RESEARCH UNIVERSITIES. YET, THESE FUNCTIONS ARE UNDER EXTENSIVE STRAIN DUE TO COMPETING PRIORITIES AND LIMITED RESOURCES. THE PROJECT TEAM USES RECENT DATA FROM SMALL AND LARGE DATA COLLECTIONS, EARLIER LITERATURE, AND EXPERT CONSULTATIONS TO DEVELOP CONCISE BACKGROUND MATERIALS AND AGENDAS TO BETTER UNDERSTAND THE NATURE AND VARIATIONS OF RD AMONG PUIS. BY CONVENING A SERIES OF REGIONAL TWO-DAY WORKSHOPS, APPROXIMATELY 16 PARTICIPANTS (PER WORKSHOP) REPRESENTATIVE OF PUI TYPES AND RD PERSONNEL, MATERIALS WILL BE REVIEWED AND SPECIFIC IDEAS AND PRIORITIES DEVELOPED. SUBSEQUENT PUBLIC WEBINARS AND RELATED CHANNELS ADD TO THE BASIS FOR A REPORT WITH NATIONAL RECOMMENDATIONS FOR EVIDENCE DEVELOPMENT, DEMONSTRATION PROGRAMS, AND EVALUATION TO PROMOTE SYSTEMIC LONG-TERM ENHANCEMENT OF THE PUI RESEARCH ENTERPRISE. BY CRYSTALLIZING KNOWLEDGE OF UNIQUE ASPECTS OF PUI RD CHALLENGES, PROMOTING STRENGTH-BASED RATHER THAN DEFICIT-BASED MODELING OF PUI NEEDS, CAPACITIES, AND GROWTH PATHS, AND BROADENING THE PARTICIPATION OF CURRENTLY LESS ACTIVE SEGMENTS OF THE PUI UNIVERSE, THE PROJECT WILL PROVIDE CONCRETE, INDEPENDENT, EXPERT SUGGESTIONS ON HOW TO ENHANCE NATIONAL NETWORKS OF COMMUNICATION AND SERVICE TO MORE EFFECTIVELY SUPPORT PUI RESEARCH ACTIVITIES, THUS SPREADING RESEARCH EXPERIENCE, KNOWLEDGE, AND RESOURCES TO NEW AND POTENTIALLY UNDERSERVED COMMUNITIES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

COLLABORATIVE RESEARCH: SCIENCE OF INFORMATION: BRINGING MANY DISCIPLINES TOGETHER

MACROSYSTEMS BIOLOGY AND NEON ENABLED SCIENCE INVESTIGATOR MEETING

COLLABORATIVE PROPOSAL: MRA: LOCAL- TO CONTINENTAL-SCALE DRIVERS OF BIODIVERSITY ACROSS THE NATIONAL ECOLOGICAL OBSERVATORY NETWORK (NEON)

COLLABORATIVE RESEARCH: HOLLOW NANOPARTICLE SYNTHESIS - TEMPLATING ELECTROCHEMICALLY EVOLVED HYDROGEN NANOBUBBLES

NUVUK: THULE CEMETERY AND CONTACT VILLAGE

COLLABORATIVE RESEARCH: RECONSTRUCTING AN EARLY URBAN LANDSCAPE -THIS RESEARCH FOCUSES ON ONE OF THE UNITED STATE?S EARLIEST CITIES WHICH EVEN AFTER DECADES OF PROFESSIONAL FIELDWORK AND ANALYSIS SOME OF THE MOST FUNDAMENTAL FACTS OF ITS GROWTH AND ORGANIZATION REMAIN UNCLEAR. CURRENT MODELS SUGGEST THAT IN LITTLE MORE THAN A CENTURY IT ATTRACTED LARGE NUMBERS OF IMMIGRANTS FROM ELSEWHERE IN THE MIDCONTINENT AND BECAME THE PREEMINENT CENTER IN ALL NORTH AMERICA. DRAWING ON THEORETICAL APPROACHES THE PROJECT SEEKS TO EXPLORE ITS TRAJECTORY OF GROWTH AS THE MAKING OF AN URBAN LANDSCAPE. YET UNDERSTANDING URBANISM REQUIRES LARGE-SCALE SPATIAL DATA ON THE GROWTH OF SUCH CENTERS IN THE EARLY YEARS OF THEIR DEVELOPMENT. TO ADDRESS THIS PROBLEM, THE RESEARCH TEAM WILL PERFORM HIGH-RESOLUTION MAGNETOMETRY OVER THE SITE. THIS MASSIVE SUBSURFACE SURVEY WILL COVER MORE THAN 5.5 KM2 OF URBAN LANDSCAPE, MAKING IT THE LARGEST SUCH SURVEY EVER CONDUCTED IN THE AMERICAS OF AN ARCHAEOLOGICAL SITE. THIS PROJECT WILL PROVIDE THE FIRST NEAR-TOTAL GEOPHYSICAL SURVEY OF THE SUBSURFACE. DATA FROM THE MAGNETOMETER SURVEY, COMBINED WITH RIGOROUS GIS AND GEOSPATIAL ANALYSES, WILL ALLOW US TO FINALLY ?SEE? BENEATH THE SURFACE FROM A BIRDS-EYE VIEW, THUS AFFORDING AN UNPARALLELED OPPORTUNITY TO COMPARE GROWTH WITH OTHER EARLY CASES OF URBAN FORMATION AROUND THE WORLD. THIS PROJECT WILL INCLUDE NOT ONLY THE FIRST SITE-WIDE MAP OF THE BURIED LANDSCAPE BUT WILL ALSO PROVIDE INSIGHTS INTO THE WAYS THAT INDIGENOUS PEOPLES COALESCED TO FORM THE LARGEST PRECOLONIAL COMMUNITY IN THE US. THE INVESTIGATION WILL ALSO PROVIDE A DATASET OF INCALCULABLE VALUE FOR FUTURE PLANNING AT THE SITE WHICH IS VISITED BY A QUARTER-MILLION VISITORS EACH YEAR. AFTER THE PROJECT, THESE DATA WILL BE MADE AVAILABLE TO OTHER SCHOLARS AND STUDENTS VIA THE DIGITAL ARCHAEOLOGICAL RECORD (TDAR) AND A WEB PORTAL HOSTED BY THE UNIVERSITY OF MICHIGAN. THE DIGITAL ATLAS WILL BECOME THE BASIS FOR FUTURE INVESTIGATIONS WITHIN THE SITE?S CENTRAL CORE, FORMING A FOUNDATION FOR MULTI-YEAR RESEARCH PROJECTS, PH.D. DISSERTATIONS AND M.A. THESES, AND EVEN PROJECTS THROUGH WHICH MIDDLE AND HIGH SCHOOL STUDENTS LEARN GIS TECHNIQUES WHILE EXPLORING AMERICA?S FIRST CITY. THROUGH CONSULTATION WITH THE ILLINOIS HISTORIC PRESERVATION AGENCY (SHPO), AND ACROSS TRIBAL HISTORIC PRESERVATION OFFICERS (THPOS), THE PROJECT ALSO PROMISES SUSTAINED COLLABORATION WITH INDIGENOUS TRIBES WHO CLAIM THE SITE AS AN ANCESTRAL HOMELAND. THIS WILL ENSURE THAT THE OPPORTUNITY AND RESPONSIBILITY TO SERVE AS STAKEHOLDERS IN STEWARDSHIP OF THESE SENSITIVE DATA ARE WIDELY SHARED. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

CC* STRATEGY-CAMPUS: COLLABORATIVE DEVELOPMENT OF CI PLAN FOR BRYN MAWR COLLEGE -BRYN MAWR COLLEGE IS DEVELOPING A COMPREHENSIVE STRATEGIC PLAN FOR BUILDING THE RESEARCH COMPUTING INFRASTRUCTURE AND SERVICES NEEDED TO SUPPORT COMPUTATIONAL RESEARCH AND TEACHING ACROSS THE CURRICULUM. WITH SUPPORT FROM OUTSIDE CONSULTANTS WITH RESEARCH COMPUTING FACILITATION AND CYBERINFRASTRUCTURE EXPERTISE, THE INFORMATION TECHNOLOGY STAFF, FACULTY RESEARCHERS, AND ADMINISTRATIVE STAKEHOLDERS ARE ASSESSING CURRENT AND EMERGING RESEARCH NEEDS, TRANSLATING THEM INTO CONCRETE CYBERINFRASTRUCTURE AND SERVICE REQUIREMENTS, AND DEVELOPING A PLAN FOR MEETING THOSE REQUIREMENTS USING A COMBINATION OF NATIONAL, REGIONAL AND LOCALLY BUILT CYBERINFRASTRUCTURE AND SERVICES. BUILDING MODERN RESEARCH COMPUTING AND DATA SUPPORT SERVICES AND INFRASTRUCTURE FURTHERS BRYN MAWR COLLEGE?S LONG-STANDING ACHIEVEMENTS IN SCIENTIFIC RESEARCH AND PREPARING STUDENTS FOR GRADUATE STUDY AND CAREERS IN STEM. THESE SERVICES AND INFRASTRUCTURE WILL PROVIDE A MORE SECURE AND SUSTAINABLE FRAMEWORK FOR FACULTY WHOSE RESEARCH AND TEACHING ALREADY INVOLVES BIG DATA OR HIGH-PERFORMANCE COMPUTING. SUPPORTING MODERN FACULTY RESEARCH NEEDS IN TURN ENSURE THAT STUDENTS GAIN EXPERIENCE WITH THE COMPUTATIONAL METHODS AND MODERN COMPUTATIONAL ECOSYSTEMS NEEDED TO WORK IN FACULTY LABS AND PREPARE FOR GRADUATE STUDY AND CAREERS IN STEM AND BEYOND. RESEARCH COMPUTING ITSELF IS ALSO A GROWING FIELD WITH ACUTE STAFFING NEEDS. BRYN MAWR COLLEGE HAS A STRONG HISTORY OF DEVELOPING STUDENT EMPLOYMENT PROGRAMS THAT GIVE STUDENTS MEANINGFUL CAREER-EXPLORATION OPPORTUNITIES WHILE PROVIDING TECHNICAL SUPPORT FOR FACULTY AND STAFF, AND WILL USE THIS STRATEGIC PLANNING PROCESS TO EXPLORE THE FEASIBILITY OF DEVELOPING A SIMILAR PROGRAM AS PART OF A RESEARCH COMPUTING AND DATA SUPPORT MODEL. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

CONFERENCE ON STEM TEACHER PREPARATION AT LIBERAL ARTS INSTITUTIONS

PHILADELPHIA REGIONAL PRE- AND IN-SERVICE TEACHER CONFERENCE SERIES ON INTEGRATING STEM IN EVERYDAY LIFE

STARTER GRANT: TESTING SIMULATION MODELS OF ANIMAL MOVEMENT UNDER THERMOREGULATORY CONSTRAINT

PRESERVATION STUDY FOR SPECIAL COLLECTIONS AT BRYN MAWR COLLEGE

HISTORY OF WOMEN'S EDUCATION OPEN ACCESS PORTAL PROJECT

COLLABORATIVE RESEARCH: SEA-LEVEL RISE AND SALT-MARSH RESPONSE: A PALEO PERSPECTIVE

COLLABORATIVE RESEARCH: FOLD FORM, STRAIN, AND MECHANICS AT THE WHALEBACK ANTICLINE: NEW APPROACHES TO A CLASSIC FIELD LOCALITY

CONFERENCE: COMBINATORIAL ALGEBRA MEETS ALGEBRAIC COMBINATORICS -THIS AWARD SUPPORTS US-BASED PARTICIPANTS AT THE CONFERENCE ?COMBINATORIAL ALGEBRA MEETS ALGEBRAIC COMBINATORICS? (CAAC) IN 2026 AND 2027. INITIATED IN 2004, CAAC IS AN ANNUAL CONFERENCE HELD IN CANADA THAT BRINGS TOGETHER RESEARCHERS SPECIALIZING IN COMBINATORIAL ALGEBRA AND ALGEBRAIC COMBINATORICS TO SHARE RECENT ADVANCES ON THE INTERFACE OF THE TWO FIELDS. CAAC 2026 AND 2027 WILL EACH FEATURE INVITED LECTURES BY LEADING RESEARCHERS SPECIALIZING IN A VARIETY OF TOPICS ACROSS COMBINATORIAL ALGEBRA AND ALGEBRAIC COMBINATORICS. EACH CONFERENCE PROGRAM WILL ALSO INCLUDE CONTRIBUTED TALKS, A POSTER SESSION, AND TIME FOR INFORMAL MATHEMATICAL DISCUSSIONS. THESE MEETINGS AIM TO FOSTER CROSS-DISCIPLINARY COLLABORATIONS, AND TO SUPPORT EARLY-CAREER RESEARCHERS BY EXPOSING THEM TO IDEAS FROM ADJACENT FIELDS AND GIVING THEM THE OPPORTUNITY TO ENGAGE WITH THE GLOBAL MATHEMATICAL COMMUNITY. THE 2026 AND 2027 CAAC MEETINGS WILL INCLUDE LECTURES BY EXPERTS IN ALGEBRAIC, ENUMERATIVE, AND GEOMETRIC COMBINATORICS, AS WELL AS IN COMMUTATIVE AND NON-LINEAR ALGEBRA, AND IN ALGEBRAIC GEOMETRY. EACH PROGRAM WILL BE DESIGNED TO INCLUDE RECENT RESEARCH RESULTS, WITH PARTICULAR EMPHASIS ON CONNECTIONS BETWEEN FIELDS. MORE INFORMATION CAN BE FOUND ON MEETING WEBSITES; THE CURRENT CAAC WEBSITE IS HTTPS://SITES.GOOGLE.COM/VIEW/CAAC2025. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

EMERGENCY RECOVERY AND PRELIMINARY STUDY OF CATARRHINE PRIMATE FOSSILS FROM THE YONGLE LIGNITE MINE ZHAOTONG YUNNAN PROVINCE CHINA

METABOLIC SCALING THEORY (MST) EXPLAINS THE ABUNDANCE AND DISTRIBUTION OF LIFE ON EARTH THROUGH A GENERAL ENERGETIC FRAMEWORK.

RAPID: EMERGENCY EXCAVATION OF ERODING STRUCTURE, WALAKPA, ALASKA

RAPID: SALVAGE AND PROCESSING OF SAMPLES FROM UTQIAGVIK, BARROW, ALASKA

COLLABORATIVE PROPOSAL: CCLI PHASE II: DIVERSE PARTNERSHIP FOR TEACHING QUANTUM MECHANICS AND MODERN PHYSICS WITH PHOTON COUNTING INSTRUMENTATION

COLLABORATIVE RESEARCH: MRA: MODELING AND FORECASTING PHENOLOGY ACROSS SPATIOTEMPORAL AND TAXONOMIC SCALES USING ECOLOGICAL OBSERVATORY AND MOBILIZED DIGITAL HERBARIUM DATA

FY 2014 SUMMER UNDERGRADUATE RESEARCH FELLOWSHIP - PML/PL

DISSERTATION IMPROVEMENT GRANT: THE ARCHAEOLOGY OF HITTITE IMPERIALISM AND CERAMIC PRODUCTION IN LATE BRONZE AGE CILICIA

FY 2016 SUMMER UNDERGRADUATE RESEARCH FELLOWSHIP PML- PL