Dickinson College

DEPT OF EDUCATION HEERF CARES ACT INSTITUTIONAL FUNDING - DICKINSON

DICKINSON COLLEGE : DEPT OF EDUCATION CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND

FY10 ONE-TIME GRANT COMPETITION - COMPETITION B - PROFESSIONAL CULTURAL YOUTH PROGRAMS"

DEVELOPING A SCIENCE POSSE PROGRAM

A CAMPAIGN TO IMPROVE TEACHING AND LEARNING ABOUT GLOBAL CLIMATE CHANGE WILL BE IMPLEMENTED AT DICKINSON COLLEGE, A 4-YEAR LIBERAL ARTS COLLEGE LOCAT

ORTHOGONAL SPLIT LUCIFERASES FOR IMAGING MULTIPLEXED CELLULAR BEHAVIORS - PROJECT SUMMARY DISEASE STATES ARE CHARACTERIZED BY COMPLEX INTERACTIONS THAT OCCUR BETWEEN A VARIETY OF CELL TYPES AND BIOMOLECULES IN AN ORGANISM. RESEARCHERS HAVE TURNED TO BIOLUMINESCENCE IMAGING (BLI) TO TRACK THE BEHAVIOR OF THESE CELLS AND UNDERSTAND THE UNDERPINNINGS OF DISEASE AND THE DEVELOPMENT OF EFFECTIVE TREATMENTS. BLI UTILIZES THE LIGHT-EMITTING ABILITY OF BIOLUMINESCENT ENZYMES TO SENSITIVELY ILLUMINATE INDIVIDUAL CELLS WITHOUT THE NEED FOR SURGERY. BECAUSE ORGANISMS DO NOT GLOW, BLI IS EXQUISITELY SENSITIVE, WITH THE ABILITY TO DETECT AS FEW AS ONE GLOWING CELL IN THE BODY OF A MOUSE. THIS HAS ENABLED RESEARCHERS TO STUDY THE EFCACY OF CANCER-KILLING DRUGS, THE LOCATION AND PROGRESSION OF INFECTION, AND THE SUCCESS OF STEM CELL TREATMENTS. DESPITE ITS UBIQUITY IN THE ELD, BLI OF MULTIPLE DIFFERENT CELL TYPES SIMULTANEOUSLY REMAINS DIFCULT. OUR RESEARCH SEEKS TO FURTHER EXPAND THE UTILITY OF THIS TOOL THROUGH A UNIQUE APPROACH TO MULTICOMPONENT BIOLUMINESCENCE IMAGING. TO ACCOMPLISH THIS, WE WILL REPURPOSE A SPLIT BIOLUMINESCENT PROTEIN CALLED NANOBIT. NANOBIT COMPRISES A HETERODIMER BINDING PAIR MADE UP OF A SMALL PEPTIDE, CALLED SMBIT, AND A LARGER PROTEIN SUBUNIT, CALLED LGBIT. NANOBIT IS ONLY CAPABLE OF LIGHT EMISSION WHEN SMBIT AND LGBIT BIND. IN AIM 1 OF THE PROPOSAL, WE WILL USE PROTEIN ENGINEERING AND DIRECTED EVOLUTION TECHNIQUES TO PRODUCE ORTHOGONAL SMBIT-LGBIT BINDING PAIRS. LIBRARIES OF LGBIT ENZYMES WILL BE CLONED, AND A PANEL OF SMBIT PEPTIDES WILL BE SYNTHESIZED. HIGH-THROUGHPUT TECHNIQUES WILL EVALUATE THE LIGHT EMISSION OF EACH LGBIT MUTANT IN COMBINATION WITH EACH SMBIT PEPTIDE. "WINNING" MUTANTS WILL BE SEQUENCED VIA NEXT GENERATION SEQUENCING (NGS) AND MUTATIONS WILL BE COMBINED TO FORM OPTIMIZED ORTHOGONAL PROBES. IN AIM 2 WE WILL TEST OUR NEW ORTHOGONAL NANOBIT PROBES IN MAMMALIAN CELLS, TISSUE MODELS, AND IN THE BODIES OF LIVE MICE. FIRST, TO IMPROVE THE TISSUE PENETRATION OF NANOBIT LIGHT EMISSION, WE WILL MODULATE THE COLOR OF BIOLUMINESCENCE BY APPENDING SMALL MOLECULE UOROPHORES TO OUR SMBIT PEPTIDES. STABLE MAMMALIAN CELL LINES CONTAINING OUR PROBES WILL NEXT BE TESTED WITH OUR SMBIT-UOROPHORE PROBES IN TISSUE MODELS AND IN LIVE MICE. PROBES WILL BE JUDGED BY THEIR SENSITIVITY AND SELECTIVITY. THIS WORK WILL REPRESENT THE RST EFFORT TO ADAPT NANOBIT FOR MULTICOMPONENT IMAGING. OUR PROTEIN ENGINEERING DATA WILL BE IMMEDIATELY USEFUL TO THE BIOLUMINESCENCE IMAGING COMMUNITY. FURTHER, THESE PROBES WILL BE USEFUL FOR IMAGING PROTEIN-PROTEIN, HOST-PATHOGEN, AND CANCER-IMMUNE CELL INTERACTIONS.

COLLABORATIVE RESEARCH: NETWORK CLUSTER: BEDROCK CONTROLS ON THE DEEP CRITICAL ZONE, LANDSCAPES, AND ECOSYSTEMS

COLLABORATIVE RESEARCH: LIVEPHOTO PHYSICS INTERACTIVE VIDEO VIGNETTES

THE EFFECTS OF STIGMATIZING US AND DANISH SMOKERS

THESE FUNDS WILL BE USED TO SUPPORT DEVELOPMENT OF A FOOD WASTE AND DAIRY MANURE DIGESTION SYSTEM APPROPRIATE FOR SMALL TO MID-SIZE DAIRIES (100-300 COWS). PROJECT PERSONNEL HAVE PARTNERED WITH THE CARLISLE AREA SCHOOL DISTRICT AND A LOCAL BREWERY TO INCREASE DIVERSION OF FOOD RESIDUES TO THE FARM FOR DIGESTION AND COMPOSTING. RESEARCH ACTIVITIES WILL INCLUDE ESTABLISHING THE IMPACT OF DIFFERENT FEEDSTOCK BLENDS (MANURE, CAFETERIA WASTE, BREWERY WASTE, MILK WASTE, AND COOKING OIL) ON DIGESTER PERFORMANCE AND DIGESTATE VALUE AS CROP FERTILIZER, AS WELL AS THE IMPACT OF FOOD WASTE DIGESTION ON AN EXISTING COMPOST PROGRAM. THIS PROJECT CONSISTS OF FOUR COMPONENTS: 1) THE INSTALLATION OF AN AUTOMATED ANAEROBIC DIGESTION SYSTEM FOR PROCESSING FOOD RESIDUALS AND DAIRY MANURE INTO BIOGAS FOR ELECTRICITY AND DIGESTATE PRODUCTION. 2) INCREASED DIVERSION OF FOOD RESIDUES FROM SCHOOLS AND BUSINESSES TO ANAEROBIC DIGESTION FOR ENERGY PRODUCTION. 3) RESEARCH THAT WILL SUPPORT IMPROVED DIGESTION SYSTEM PERFORMANCE AND UTILIZATION OF DIGESTATE. 4) PROVIDE OUTREACH TO FARMERS, RECYCLING PROFESSIONALS, ACADEMICS AND THE PUBLIC TO PROMOTE ANAEROBIC DIGESTION THROUGH FIELD DAYS, CONFERENCE PRESENTATIONS, VIDEOS, YOUTH CONTENT, FACT SHEETS AND A CASE STUDY. NOTE THAT THE HEADER OF THIS AWARD CAPTIONS IT AS A GRANT AGREEMENT WHEREAS IT IS A COOPERATIVE AGREEMENT. EPA IS IMPLEMENTING A NEW GRANT SYSTEM THAT WILL SOON BE UNDERGOING ENHANCEMENTS TO ALLOW FOR MORE ACCURATE DESCRIPTIONS.

RUI: EPIGENETIC WEAPONS IN PLANT-HERBIVORE INTERACTIONS: SULFORAPHANE AS A NATURAL HISTONE DEACETYLASE INHIBITOR IN LEPIDOPTERAN PESTS -THIS PROJECT WILL INVESTIGATE A NOVEL ?EPIGENETIC WEAPON? THAT CRUCIFEROUS PLANTS DEPLOY AGAINST DESTRUCTIVE INSECT PESTS. EPIGENETIC SYSTEMS REGULATE THE EXPRESSION OF HUNDREDS OF GENES BY TEMPORARILY OPENING OR CLOSING CHROMOSOMAL SEGMENTS SO THAT THE GENES IN THESE SEGMENTS CAN BE ACTIVATED OR DE-ACTIVATED. THESE SYSTEMS DIRECT NORMAL GROWTH AND DEVELOPMENT AND ALLOW INDIVIDUALS TO RESPOND RAPIDLY TO CHANGING ENVIRONMENTS. RECENTLY, IT HAS BEEN OBSERVED THAT SULFORAPHANE, A NATURAL SUBSTANCE FROM CRUCIFEROUS PLANTS (E.G., BROCCOLI, CAULIFLOWER), DISRUPTS THE EPIGENETIC CONTROL SYSTEMS OF INSECT LARVAE WHILE THEY EAT PLANT LEAVES. THUS, SULFORAPHANE MAY SERVE AS AN EPIGENETIC WEAPON AGAINST PEST INSECTS. THIS WOULD REPRESENT A NEW CATEGORY OF PLANT DEFENSE, ONE WITH THE POTENTIAL TO SABOTAGE INSECT DEVELOPMENT AND THEREBY PROTECT CROP PLANTS. PRELIMINARY DATA INDICATE THAT THE EFFECTIVENESS OF SULFORAPHANE AGAINST PEST CATERPILLARS DEPENDS ON THE DOSAGE, THE TEMPERATURE, AND THE PEST SPECIES. GENERALIST FEEDERS SEEM TO BE MOST SUSCEPTIBLE TO THIS SUBSTANCE. IN CONTRAST, SPECIALIST INSECTS WHICH CO-EVOLVED TO FEED UPON THESE PLANTS SEEM TO HAVE DEVELOPED PARTIAL RESISTANCE, BY SOME UNKNOWN MECHANISM. TO EXPLORE THIS MECHANISM OF RESISTANCE, THE LARVAL DEVELOPMENT OF THREE ECONOMICALLY IMPORTANT PEST SPECIES WILL BE EXAMINED AS THEY CONSUME VARIOUS DOSES OF SULFORAPHANE OVER A RANGE OF TEMPERATURES. EXPERIMENTS WILL DETERMINE THE IMPACTS OF THIS SUBSTANCE ON (1) LARVAL SURVIVAL AND DEVELOPMENT, (2) THE HEALTH OF ADULT MOTHS AND BUTTERFLIES, (3) THE EPIGENETIC CONTROL SYSTEMS OF THESE INSECTS, AND (4) THE EXPRESSION OF GENES ASSOCIATED WITH IMPORTANT METABOLIC PATHWAYS AND PROCESSES. THE POSSIBILITY THAT THE EPIGENETIC CHANGES INDUCED BY SULFORAPHANE MAY LINGER, AFFECTING FUTURE GENERATIONS WHICH MAY NOT HAVE CONSUMED THIS SUBSTANCE, WILL ALSO BE EVALUATED. THIS PROJECT MAY SUGGEST NEW METHODS FOR PROTECTING CROP PLANTS AND IMPROVE OUR UNDERSTANDING HOW PLANTS INFLUENCE INSECT POPULATIONS. IT WILL ALSO SUPPORT THE EDUCATION OF A DIVERSE GROUP OF ~20 UNDERGRADUATES OVER THREE YEARS, PREPARING THESE STUDENTS FOR GRADUATE- AND PROFESSIONAL-LEVEL WORK IN RELATED FIELDS. CRUCIFEROUS PLANTS PRODUCE SULFORAPHANE (SFN), AN INHIBITOR OF NUCLEAR HISTONE DEACETYLASES (HDACS) WHICH HAS BEEN INVESTIGATED AS A POTENTIAL DRUG AND DIETARY SUPPLEMENT. IN HUMANS, SULFORAPHANE CONSUMPTION ALTERS ENZYME ACTIVITY, DNA-HISTONE BINDING, AND GENE EXPRESSION WITHIN MINUTES. HOWEVER, THE ABILITY OF SFN TO ACT AS A HDAC INHIBITOR IN NATURE, DISRUPTING THE EPIGENETIC MACHINERY OF HERBIVOROUS INSECTS, HAS NEVER BEEN EXPLORED. IT IS PROPOSED THAT PLANTS CAN EMPLOY SFN AS AN ?EPIGENETIC WEAPON?. PRELIMINARY DATA DEMONSTRATE THAT DIETARY SFN DRAMATICALLY REDUCES THE HDAC ACTIVITY AND SLOWS DEVELOPMENT OF THE ARMY WORM (SPODOPTERA EXIGUA), SOMETIMES AFFECTING SECOND-GENERATION LARVAE. IN CONTRAST, THE CABBAGE LOOPER (TRICHOPLUSIA NI) SEEMS TO BE PARTIALLY RESISTANT TO SFN. TO EXPLORE THIS FURTHER, THE INVESTIGATORS WILL DETERMINE HOW SFN ALTERS DEVELOPMENT, HDAC ACTIVITY, HISTONE ACETYLATION, AND GLOBAL GENE EXPRESSION IN 1ST AND 2ND GENERATION LARVAE OF THREE HERBIVORES WHICH FEED ON THESE PLANTS: PIERIS RAPAE (CABBAGE WHITE), TRICHOPLUSIA NI (CABBAGE LOOPER), SPODOPTERA EXIGUA (ARMY WORM). THESE RESPONSES WILL BE EXAMINED OVER A RANGE OF TEMPERATURES. RNA-SEQ WILL BE USED TO ANALYZE DIFFERENTIAL GENE EXPRESSION, ORTHOLOGOUS GENE GROUPS WILL BE IDENTIFIED, THE PUTATIVE FUNCTION OF DIFFERENTIALLY EXPRESSED GENES WILL BE PREDICTED USING GENE ONTOLOGY CLASSIFICATIONS, AND DIFFERENTIALLY EXPRESSED GENES WILL BE MAPPED TO METABOLIC PATHWAYS. THE PROPOSED EXPERIMENTS WOULD, FOR THE FIRST TIME, TEST THE HYPOTHESIS THAT PLANT HDAC INHIBITORS CAN INTERFERE WITH THE EPIGENETIC MACHINERY OF INSECTS. THIS WOULD REPRESENT A NEW CATEGORY OF PLANT DEFENSE. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

COLLABORATIVE RESEARCH: BUILDING THE CONTRACTILE RING IN THE EARLY EMBRYO

PROJECT TO REDUCE SEXUAL ASSAULT, DOMESTIC VIOLENCE, DATING VIOLENCE AND STALKING AT DICKINSON COLLEGE

COLLABORATIVE RESEARCH/RUI: G PROTEIN REGULATION OF THE ACTIN CYTOSKELETON IN THE CLEAVAGE STAGE EMBRYO

OCEAN ACIDIFICATION/COLLABORATIVE RESEARCH/RUI: EFFECTS OF OCEAN ACIDIFICATION ON LARVAL COMPETENCE, METAMORPHOSIS, AND JUVENILE PERFORMANCE IN A PLA

P18AC00145

COLLABORATIVE RESEARCH: BROADENING PARTICIPATION IN COMPUTING THROUGH AUTHENTIC, COLLABORATIVE ENGAGEMENT WITH COMPUTING FOR THE GREATER GOOD

UBM-GROUP: AN INTEGRATIVE ANALYSIS OF HUMAN CANCER: EXPLOITING THE SYNERGY OF MATHEMATICAL AND MOLECULAR BIOLOGICAL APPROACHES IN STUDYING A COMPLEX

RUI: ELECTROPHILIC MODULATION OF THE HEAT SHOCK RESPONSE SYSTEM

DEVELOPMENT OF AN INTERDISCIPLINARY COURSE CHEMICAL ANALYSIS IN CHEMICAL ECOLOGY

RUI: USING THE PRODUCTS OF VOLCANO-ICE INTERACTION TO CONSTRAIN PALEO-ICE CONDITIONS II: DOCUMENTING FLUCTUATIONS IN CONTINENTAL ICE-SHEETS

MORALIZATION, RISK PERCEPTIONS, AND SMOKING CESSATION IN THE U.S. AND DENMARK

UNDERGRADUATE INTERNATIONAL STUDIES AND FOREIGN LANGUAGE

INTEGRATING PHOTON QUANTUM MECHANICS IN THE UNDERGRADUATE CURRICULUM

BRC-BIO: TRADE-OFFS IN LOCOMOTOR PERFORMANCE: COMPARING HOPPERS AND JUMPERS IN VARIABLE ENVIRONMENTS -THE WAY AN ORGANISM NAVIGATES AN ENVIRONMENT OR HABITAT CAN BE INFLUENCED BY AN INDIVIDUAL?S PHYSIOLOGY AND THE PHYSICAL PROPERTIES OF ITS ENVIRONMENT. MORE SPECIFICALLY, THE SUBSTRATE AN ORGANISM INTERACTS WITH CAN POSE VARIOUS CHALLENGES DURING LOCOMOTOR MOVEMENTS THAT CAN IMPACT PERFORMANCE. ADAPTATIONS IN MOVEMENT REQUIRE A DYNAMIC INTERPLAY BETWEEN AN ORGANISMS? NERVOUS SYSTEM, ANATOMY, AND MUSCLE PHYSIOLOGY, WHICH TOGETHER DRIVE WHOLE-BODY MOVEMENTS. HOWEVER, THE PHYSIOLOGICAL STRATEGIES THAT ONE ANIMAL USES MAY NOT BE IDEALLY SUITED FOR A DIFFERENT HABITAT OR SUBSTRATE TYPE. THIS RESEARCH AIMS TO UNDERSTAND HOW SPECIALIZED WAYS OF MOVEMENT, MORE SPECIFICALLY, HOW HOPPING AND JUMPING MAY CONSTRAIN HOW AN ORGANISM RESPONDS TO INSTANTANEOUS CHANGES IN THE ENVIRONMENT. FROGS AND TOADS PROVIDE A UNIQUE MODEL TO UNDERSTAND VARIATION IN MOVEMENT STRATEGIES. THIS PROJECT WILL INVESTIGATE WHOLE-BODY MOVEMENT AND NERVOUS SYSTEM CONTROL OF MUSCLE RECRUITMENT IN RESPONSE TO CHANGES IN SUBSTRATE STIFFNESS. IN ADDITION, THE PROJECT WILL INVESTIGATE THE MECHANICS AND ORGANIZATION OF TENDON TISSUE TO BETTER UNDERSTAND THE ROLE OF TENDON STIFFNESS IN SPECIALIZED FORMS OF MOVEMENT. SUCH UNIQUE ADAPTATIONS IN MUSCLE AND TENDON PHYSIOLOGY CAN INFORM THE IMPACTS OF CHANGING ENVIRONMENTS ACROSS HABITATS ON LOCOMOTION, AS WELL AS DESIGN PARAMETERS IN ENGINEERED SYSTEMS DEALING WITH ENVIRONMENTAL DISTURBANCE. THE BROADER IMPACTS OF THIS RESEARCH WILL INCREASE RESEARCH OPPORTUNITIES AND MENTORSHIP OF UNDERGRADUATE STUDENTS HISTORICALLY UNDERREPRESENTED IN STEM, AS WELL AS ENABLE THE DEVELOPMENT OF EDUCATIONAL WORKSHOP-BASED TRAININGS AND RESOURCES TO INCREASE ACCESS TO STEM RESEARCH OPPORTUNITIES ACROSS THE HOME INSTITUTION. THROUGHOUT HISTORY THE EMERGENCE OF NEW MODES OF LOCOMOTION HAS PLAYED A CRUCIAL ROLE IN AN ANIMAL?S ABILITY TO NAVIGATE NEW HABITATS. FOR EXAMPLE, BEHAVIORAL TRANSITIONS BETWEEN MICROHABITATS MAY RESULT IN MORE SUBTLE SHIFTS IN AN ANIMAL?S LOCOMOTOR STRATEGY. IN SOME CASES, THE LOCOMOTOR SYSTEM MAY BE FLEXIBLE ENOUGH TO ACCOMMODATE CHANGES IN THE PHYSICAL PROPERTIES OF THE ENVIRONMENT. THE PROPOSED WORK AIMS TO UNDERSTAND HOW SPECIALIZED WAYS OF MOVEMENT HAVE UNIQUELY CONSTRAINED MOTOR CONTROL STRATEGIES AND MUSCLE-TENDON PROPERTIES. TO ADDRESS THIS, THE FIRST AIM WILL QUANTIFY AND COMPARE INTERSPECIFIC KINEMATIC VARIATION BETWEEN THE LONG DISTANCE, ENDURANCE HOPPING OF CANE TOADS, AND THE FAST, POWERFUL JUMPS OF CUBAN TREE FROGS, IN RESPONSE TO ENVIRONMENTAL PERTURBATIONS IN SUBSTRATE STIFFNESS. THE SECOND AIM MEASURES IN VIVO HINDLIMB MUSCLE LENGTH AND MOTOR PATTERNS IN RESPONSE TO SUBSTRATE STIFFNESS TO CHARACTERIZE THE MOTOR CONTROL MECHANISMS USED BY LONG DISTANCE ENDURANCE HOPPERS. THE THIRD AIM SEEKS TO CHARACTERIZE TENDON ULTRASTRUCTURE BY QUANTIFYING COLLAGEN FIBRIL ORGANIZATION USING TECHNIQUES IN TRANSMISSION ELECTRON MICROSCOPY AND SERIAL BLOCK-FACE SCANNING ELECTRON MICROSCOPY. LASTLY, TENDON MATERIAL PROPERTIES WILL BE QUANTIFIED USING IN VITRO TENDON TISSUE STRESS AND STRAIN TESTS TO DETERMINE THE ROLE OF TISSUE STIFFNESS ACROSS SPECIES SPECIALIZED FOR DIFFERING MODES OF LOCOMOTION AND POWER OUTPUT. THE PROPOSED RESEARCH WILL ADVANCE UNDERSTANDING OF HOW SPECIALIZATION IN DIFFERENT LOCOMOTOR MODES CAN PROVIDE ROBUST BENEFITS OR LIMITATIONS AT VARIOUS LEVELS OF PHYSIOLOGICAL ORGANIZATION. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

COLLABORATIVE RESEARCH/RUI: TESTING HYPOTHESES ON PILLOW LAVA PRODUCTION DURING GLACIOVOLCANIC ERUPTIONS

COLLABORATIVE RESEARCH/RUI: IDENTIFICATION OF CIS-ACTING SEQUENCE AND STRUCTURAL ELEMENTS REQUIRED FOR REPLICATION OF A VIRAL RNA

NPS FINANCIAL ASSISTANCE AGREEMENT PROJECT ABSTRACTCOMPETITIVE AWARD AGREEMENT REQUIREMENTSFUNDING OPPORTUNITY NUMBER N AFUNDING OPPORTUNITY GOALS TEXT N AREQUIREMENTS FOR ALL AGREEMENTSA PROJECT TITLE PREPARE SPECIAL HISTORY OF KENTUCKY SLAVE STAMPEDES AT CAMP NELSON NATIONAL MONUMENT B PERFORMANCE GOALS THE OVERALL GOAL OF THIS PROJECT IS TO DEVELOP A BETTER UNDERSTANDING OF THE PHENOMENON OF SLAVE STAMPEDES TO SUPPORT THE MANAGEMENT AT CAMP NELSON NM IT WILL ALSO EXPLORE THE RELATIONSHIP BETWEEN SINGLE PERSON ESCAPES AND MULTI PERSON ESCAPES C AWARD PURPOSE DICKINSON COLLEGE WORKING IN CONJUNCTION WITH NPS TO PRODUCE A SPECIAL HISTORY OF KENTUCKY SLAVE STAMPEDES AT CAMP NELSON MODERN SCHOLARSHIP ON THE UNDERGROUND RAILROAD HAS NOT EMPHASIZED THE HISTORICAL IMPACT OF MASS ESCAPES SUCH AS SLAVE STAMPEDES WHILE THE PROJECT IS REGIONALLY FOCUSED, IT WILL PROVIDE A CONTEXT FOR LOOKING MORE BROADLY AT SUCH INCIDENTS HELPING TO BETTER UNDERSTAND SLAVERY AND FREEDOM D ACTIVITIES TO BE PERFORMED DICKINSON BEGINS ORGANIZING KENTUCKY MATERIAL FROM MISSOURI BORDERLANDS PROJECT AND CONSULTS WITH NPS STAFF ON RESEARCH PRIORITIESDECEMBER 2022LAUNCH OF ONLINE RESEARCH JOURNAL, PUBLICATION OF INITIAL STAMPEDE NARRATIVES AND VIDEOS, CONTINUATION OF ONLINE RESEARCH, DRAFT OF INTRODUCTORY ESSAYAUGUST 2023DRAFT OF KENTUCKY REPORT SHARED WITH NPS, EXPANSION OF GIS MAPS, VIDEOS, NARRATIVES AND DATABASE RECORDS INITIAL PRESENTATION OF SITE CANDIDATES FOR ADDITION TO NPS NETWORK TO FREEDOMAUGUST 2024SPECIALIZED CONSULTANT REPORTS ON SELECT CANDIDATE SITES REVISED KENTUCKY REPORT AND REVIEW OF ONLINE REPORT PRESENTATIONAUGUST 2025LAUNCH OF DATABASE AND ONLINE REPORT REVISED APPLICATION PACKETS SHARED WITH NPSDECEMBER 2025

EXECUTE A BALANCED SCIENCE PROGRAM BASED ON DISCIPLINE-SPECIFIC GUIDANCE FROM THE NATIONAL ACADEMIES OF SCIENCES ENGINEERING AND MEDICINE ADMINISTRATION PRIORITIES AND DIRECTION FROM CONGRESS. PARTICIPATE AS A KEY PARTNER AND ENABLER IN THE AGE

COLLABORATIVE RESEARCH: RECONSTRUCTING DOMESTICATION AND LANDSCAPE MANAGEMENT PROCESSES

COLLABORATIVE RESEARCH: COMPETING SINKS AS CONSTRAINTS ON PLANT DEFENSE RESPONSES

COLLABORATIVE RESEARCH: ICE FORCING IN ARC MAGMA PLUMBING SYSTEMS (IF-AMPS)

COLLABORATIVE RESEARCH/RUI: QUANTIFYING WEATHERING RIND FORMATION RATES USING U-SERIES ISOTOPES ALONG STEEP GRADIENTS OF PRECIPITATION, BEDROCK AGES,

COLLABORATIVE RESEARCH: USING THE PRODUCTS OF VOLCANO-ICE INTERACTION TO CONSTRAIN PALEO-ICE CONDITIONS

TWO-WAY SCHOLAR EXCHANGE: BEST PRACTICES IN LIBERAL ARTS TEACHING

SECURING STAFF TO SUPPORT TWO HUMANITIES ARCHIVAL OUTREACH PROJECTS AT DICKINSON COLLEGE DURING COVID-19

TO SUPPORT A PROJECT TO ENHANCE PUBLIC ENGAGEMENT, DISCOVERY, AND GATHER CONTRIBUTIONS TO THE CARLISLE INDIAN SCHOOL DIGITAL RESOURCE CENTER. DICKINSON COLLEGE HAS DIGITIZED MORE THAN 225,000 PAGES OF RECORDS FROM THE CARLISLE INDIAN SCHOOL (1879-1918), WHICH WAS DESIGNED TO ASSIMILATE NATIVE CHILDREN INTO MAINSTREAM EURO-AMERICAN SOCIETY. THE PROJECT WILL OFFER A CURRICULUM DEVELOPMENT WORKSHOP FOR 12 HIGH SCHOOL TEACHERS TO DEVELOP LESSON PLANS USING THE CENTER?S MATERIALS; AND WORKSHOPS IN FIVE NATIVE COMMUNITIES TO SHARE CURRICULAR MATERIALS, SOLICIT EVALUATION OF THE CENTER, AND ENCOURAGE COMMUNITY MEMBERS TO CONTRIBUTE MATERIALS TO THE CENTER.

AGRICULTURAL PESTICIDES POSE A RISK TO THE WILD AND MANAGED POLLINATORS ESSENTIAL TO FOOD PRODUCTION AND THE FUNCTION OF NATURAL ECOSYSTEMS. WE PROPOSE LEVERAGING RECENTLY GENERATED NOVEL DATASETS DESCRIBING PESTICIDE USE BY ACTIVE INGREDIENT (KG 1997 THROUGH 2017 AND POTENTIALLY MORE RECENT DATA IF AVAILABLE) AND AGGREGATE INSECTICIDE LOAD (KG AND HONEY BEE TOXICITY THRESHOLDS 1997 THROUGH 2014 AND POTENTIALLY OTHER NATIVE BEE TOXICITY DATA SOURCES) FOR STATE AND CROP COMBINATIONS IN THE STATES ASSOCIATED WITH THE GREAT LAKES BASIN TO PREDICT HAZARD FACED BY INSECT POLLINATORS IN THE REGION. THESE DATA ALLOW MAPPING OF PESTICIDE INDICATORS AT FINE SPATIAL SCALES RELEVANT TO POLLINATOR RESEARCH AND CONSERVATION. COUPLED WITH INFORMATION ON PESTICIDE FATE AND SPECIES OCCURRENCE WE CAN PROVIDE THE FOLLOWING INSIGHTS TO POLLINATOR CONSERVATION DECISION MAKING IN THE GREAT LAKES BASIN (1) WHERE AND HOW ARE PESTICIDE HAZARDS TO POLLINATORS DISTRIBUTED OVER THE LANDSCAPE AND (2) WHERE AND HOW CAN PESTICIDE MITIGATION MOST EFFECTIVELY AID POLLINATOR CONSERVATION. THESE INSIGHTS WILL AID IN (1) PLANNING FOR POLLINATOR HABITAT RESTORATION AND ENHANCEMENT (LOW CHEMICAL HAZARD AREAS) (2) HABITAT PROTECTION (LOW CHEMICAL HAZARD ENVIRONMENTS IN HIGH QUALITY POLLINATOR HABITAT) AND (3) PESTICIDE MITIGATION (HIGH HAZARD ENVIRONMENTS OTHERWISE SUITABLE FOR POLLINATORS).

RAPID: RUI: CONSTRAINTS ON FRAGMENTATION AND LAVA-ICE CONTACT FROM ONGOING 2010 EYJAFJALLAJOKULL ERUPTION SOUTHCENTRAL ICELAND

ANALYSIS AND REPORTING OF EXISTING DATA ON LOW-DENSITY DETECTION OF BROWN TREESNAKES ON GUAM

COLLABORATIVE RESEARCH: GP-UP: A NEAR SURFACE GEOPHYSICS FIELD EXPERIENCE TO IMPROVE THE RECRUITMENT AND RETENTION OF UNDER-REPRESENTED MINORITY STUDENTS IN THE GEOSCIENCES

RAPID: RUI: COLLABORATIVE RESEARCH: RAPID RESPONSE TO ONGOING TOLBACHIK ERUPTION

AGRICULTURAL PESTICIDES POSE A RISK TO THE WILD AND MANAGED POLLINATORS ESSENTIAL TO FOOD PRODUCTION AND THE FUNCTION OF NATURAL ECOSYSTEMS WE PROPOSE LEVERAGING RECENTLY GENERATED NOVEL DATASETS DESCRIBING PESTICIDE USE BY ACTIVE INGREDIENT AND AGGREGATE INSECTICIDE LOAD FOR STATE CROP COMBINATIONS IN THE STATES ASSOCIATED WITH THE GREAT LAKES BASIN TO PREDICT HAZARD FACED BY INSECT POLLINATORS IN THE REGION THESE DATA ALLOW MAPPING OF PESTICIDE INDICATORS AT FINE SPATIAL SCALES RELEVANT TO POLLINATOR RESEARCH AND CONSERVATION COUPLED WITH INFORMATION ON PESTICIDE FATE AND SPECIES OCCURRENCE, WE CAN PROVIDE INSIGHTS TO POLLINATOR CONSERVATION DECISION MAKING IN THE GREAT LAKES BASIN 1 WHERE AND HOW ARE PESTICIDE HAZARDS TO POLLINATORS DISTRIBUTED OVER THE LANDSCAPE, AND 2 WHERE AND HOW CAN PESTICIDE MITIGATION MOST EFFECTIVELY AID POLLINATOR CONSERVATION ADDRESSING THESE QUESTIONS WILL AID IN PLANNING FOR POLLINATOR HABITAT RESTORATION AND ENHANCEMENT LOW CHEMICAL HAZARD AREAS , HABITAT PROTECTION LOW CHEMICAL HAZARD ENVIRONMENTS IN HIGH QUALITY POLLINATOR HABITAT AND PESTICIDE MITIGATION HIGH HAZARD ENVIRONMENTS OTHERWISE SUITABLE FOR POLLINATORS

CHESAPEAKE BAY WATERSHED AGROFORESTRY

FY 2018 SUMMER UNDERGRADUATE RESEARCH FELLOWSHIP Ý STANDARDS COORDINATION OFFICE

TO SUPPORT A PILOT CURATORIAL ARTS EDUCATION PROGRAM FOR MIDDLE SCHOOL STUDENTS.