Siloam

PURPOSE: REHABILITATE RUNWAY. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT REHABILITATES 4,997 FEET OF THE EXISTING RUNWAY 18/36 TO MAINTAIN THE STRUCTURAL INTEGRITY OF THE PAVEMENT AND TO MINIMIZE FOREIGN OBJECT DEBRIS. THIS GRANT FUNDS THE FINAL PHASE, WHICH CONSISTS OF CONSTRUCTION. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH SILOAM SPRINGS, ARKANSAS.

VALIDATION OF ARTIFICIAL INTELLIGENCE (AI) BASED SOFTWARE AS MEDICAL DEVICE (SAMD) FOR RETINOPATHY OF PREMATURITY (ROP) - THE PURPOSE OF THIS APPLICATION IS TO PERFORM THE NECESSARY CLINICAL STUDIES TO SEEK REGULATORY APPROVAL FOR AN ARTIFICIAL INTELLIGENCE (AI) SOFTWARE AS MEDICAL DEVICE (SAMD) FOR RETINOPATHY OF PREMATURITY (ROP) DIAGNOSIS. ROP IS A LEADING CAUSE OF CHILDHOOD BLINDNESS WORLDWIDE, WITH APPROXIMATELY 50,000 BABIES GOING BLIND ANNUALLY, MOST OF WHICH IS PREVENTABLE WITH ACCURATE AND TIMELY DIAGNOSIS. THE I-ROP DL ALGORITHM WAS DEVELOPED BY THE I-ROP RESEARCH CONSORTIUM AND HAS BEEN SHOWN TO PROVIDE EXPERT-LEVEL DIAGNOSIS OF PLUS DISEASE, A COMPONENT OF SEVERE ROP, BASED ON IMAGES FROM THE RETCAM (NATUS, MIDDLETON, WI) DIGITAL FUNDUS CAMERA. THE OUTPUT IS A VASCULAR SEVERITY SCORE (VSS) THAT CORRESPONDS TO SPECTRUM OF PLUS DISEASE, AS DEFINED BY THE INTERNATIONAL CLASSIFICATION OF ROP, AND HAS BEEN ENDORSED BY THE FOOD & DRUG ADMINISTRATION (FDA) AS AN APPROPRIATE OUTPUT FOR AN ROP SAMD. IF INCORPORATED INTO A CLINICAL WORKFLOW, THIS TECHNOLOGY COULD PROVIDE AUTOMATED, IMMEDIATE, EXPERT-LEVEL DIAGNOSIS OF ROP TO THE BEDSIDE, SOLVING ONE OF THE KEY GAPS IN CARE THAT RESULTS IN PREVENTABLE BLINDNESS WORLDWIDE. THE FIRST AIM OF THIS PROJECT IS TO UPDATE AND RETRAIN THE I-ROP DL ALGORITHM TO IMPROVE SPEED AND REPEATABILITY FOR CLINICAL USE, FINALIZE THE IMAGE QUALITY AND PRE-PROCESSING PIPELINE, AND INTEGRATE IT INTO THE ITELEGEN DATA MANAGEMENT SYSTEM, AN ROP TELEMEDICINE SOFTWARE PLATFORM. THE SECOND AIM IS TO PERFORM THE NECESSARY CLINICAL STUDIES FOR THE TWO PROPOSED INDICATIONS FOR USE (IFU): THE FIRST IFU WILL BE AS AN ASSISTIVE DIAGNOSTIC STUDY TO IMPROVE THE CLINICAL DIAGNOSIS OF PLUS DISEASE WITH REGULATORY APPROVAL BASED ON A MULTI-READER MULTI-CASE STUDY WITH A PRIMARY OUTCOME OF IMPROVED DIAGNOSIS OF PLUS DISEASE, BASED ON A FIVE EXPERT REFERENCE STANDARD DIAGNOSIS, WITH THE USE OF THE VSS. THE SECOND IFU WILL BE FOR AUTONOMOUS ROP SCREENING FOR MORE THAN MILD ROP (MTMROP, DEFINED AS TYPE 2 OR WORSE ACCORDING TO THE EARLY TREATMENT FOR ROP STUDY DEFINITION). THE PIVOTAL STUDY WILL HAVE A PRIMARY OUTCOME OF 85% SENSITIVITY AND 85% SPECIFICITY FOR THE DIAGNOSIS OF MTMROP, WITH A SECONDARY OUTCOME OF GREATER THAN 95% SENSITIVITY FOR DETECTION OF TREATMENT-REQUIRING ROP. THE THIRD AIM OF THE PROPOSAL IS TO VALIDATE THE I-ROP DL ALGORITHM ON A DIGITAL FUNDUS CAMERA MADE BY FORUS HEALTH (BENGALURU, INDIA), A DIGITAL EYE CARE COMPANY, WITH ROP CAMERA DISTRIBUTION IN MORE THAN 20 COUNTRIES. IF SUCCESSFUL, THEN ONCE FDA APPROVAL IS OBTAINED ON THE RETCAM IT MAY BE EXTENDED THROUGH A 510K PROCESS TO A CAMERA THAT IS MORE AFFORDABLE THAN THE RETCAM AND WIDELY AVAILABLE IN LOW- AND MIDDLE-INCOME COUNTRIES. THIS WORK WILL BE DONE BY SILOAM VISION, A COMPANY STARTED BY TWO OF THE INVENTORS OF THE I-ROP DL ALGORITHM, IN CONJUNCTION WITH OREGON HEALTH & SCIENCE UNIVERSITY. AT THE END OF THE STUDY PERIOD, THE GOAL WILL BE TO HAVE THE NECESSARY DATA TO SUPPORT FDA APPROVAL OF THE I-ROP DL ALGORITHM FOR TWO IFUS ON TWO DIGITAL FUNDUS CAMERAS AND BEING ONE STEP CLOSER TO BRINGING THIS TECHNOLOGY TO THE BEDSIDE TO REDUCE THE NUMBER OF BABIES GOING BLIND FROM ROP WORLDWIDE.

STAFFING FOR ADEQUATE FIRE AND EMERGENCY RESPONSE (SAFER)

ULTRAWIDE FIELD NON-MYDRIATIC PORTABLE PEDIATRIC RETINAL IMAGING - SILOAM VISION AIMS TO REVOLUTIONIZE PEDIATRIC RETINAL IMAGING BY INTRODUCING TWO ADVANCED, LASER-BASED, ARTIFICIAL INTELLIGENCE (AI) ENABLED RETINAL IMAGING SYSTEMS. THESE INNOVATIONS ARE PRIMARILY TARGETED AT ADDRESSING AN UNMET NEED IN RETINOPATHY OF PREMATURITY (ROP), WHICH IS A LEADING CAUSE OF CHILD BLINDNESS IN EVERY PART OF THE WORLD, EVEN THOUGH BLINDNESS IS NEARLY ALWAYS PREVENTABLE WITH ACCURATE DIAGNOSIS AND TIMELY TREATMENT. CURRENT EXAMINATION METHODS FOR ROP REQUIRE EITHER IN PERSON DILATED EXAMINATION WITH OPHTHALMOSCOPY BY A SKILLED CLINICIAN, OR DIGITAL IMAGING USING AN AVAILABLE WIDEFIELD DIGITAL FUNDUS IMAGING (WDFI – UP TO 130 DEGREES) SYSTEM. BOTH OF THESE METHODS ARE STRESSFUL TO NEONATES BECAUSE THEY USE BRIGHT ILLUMINATION, AND ARE EXPENSIVE BECAUSE THEY EITHER TAKE THE LIMITED TIME OF A CLINICIAN, OR REQUIRE PURCHASE OF A WDFI SYSTEM ($50,000 – 150,000). SILOAM VISION'S NOVEL APPROACH INVOLVES AN INFRARED LASER-BASED CAMERA CAPABLE OF ULTRA-WIDEFIELD IMAGING (UWF - UP TO 165 DEGREES) USING A SCANNING LASER OPHTHALMOSCOPE (SLO) OR AN OPTICAL COHERENCE TOMOGRAPHY (OCT) SYSTEM, OFFERING 2D OR 3D IMAGING, RESPECTIVELY. THERE ARE NO COMMERCIALLY AVAILABLE HANDHELD OCT SYSTEMS ON THE MARKET, AND NONE OF THE CURRENT WDFI SYSTEMS MATCH THE FIELD OF VIEW (FOV) AND OPTICAL ADVANTAGES OF THESE SYSTEMS, WHICH DO NOT REQUIRE DILATION, CAN IMAGE THE ENTIRE RETINA IN A FEW SECONDS, AND USE INFRARED LIGHT TO REDUCE NEONATAL STRESS. OUR PROTOTYPE UWF OCT SYSTEM HAS ALREADY BEEN SUCCESSFULLY UTILIZED IN OVER 2000 ROP EXAMS, DEMONSTRATING THE POTENTIAL OF QUANTITATIVE OCT BIOMARKERS IN CLINICAL DISEASE STAGING, BUT AS BUILT IS TOO EXPENSIVE FOR COMMERCIALIZATION. TO ADDRESS THIS, AND TO BRING THIS TECHNOLOGY TO MARKET FASTER, WE ARE LEVERAGING THE EXISTING DATASET OF UWF-OCT IMAGES TO DEVELOP SUPER RESOLUTION AI ALGORITHMS THAT CAN MATCH THE RESOLUTION AND FOV OF OUR CURRENT PROTOTYPE, USING LOWER-COST COMPONENTS, A STRATEGY THAT HAS BEEN USED SUCCESSFULLY IN RADIOLOGY. THUS, THERE ARE TWO KEY INNOVATIONS THAT WE ARE DEVELOPING: A WIDER FOV CAMERA DESIGN THAT CAN BE PAIRED WITH EITHER AN SLO OR OCT, AND SUPER-RESOLUTION AI TO MAKE UWF-OCT COMMERCIALLY VIABLE. THE PROJECT IS STRUCTURED AROUND TWO SPECIFIC AIMS: AIM 1: OPTIMIZE THE PERFORMANCE AND COST OF THE OCT DEVICE USING SUPER-RESOLUTION TECHNIQUES, LIKE GENERATIVE ADVERSARIAL NETWORKS, TO IMPROVE IMAGE QUALITY WHILE REDUCING COSTS. THIS INVOLVES COMPARING IMAGES FROM 100 KHZ AND 400 KHZ LASERS, AIMING TO ACHIEVE SIMILAR CLINICAL UTILITY WITH CHEAPER COMPONENTS. AIM 2: DEVELOP COMMERCIAL READY SLO AND OCT SYSTEMS, READY FOR REGULATORY APPROVAL. THIS INCLUDES REFINING THE DESIGN TO REDUCE COST, SIZE, AND WEIGHT, AND CONDUCTING A FEASIBILITY STUDY FOR NON-MYDRIATIC IMAGING. FOR THE ROP MARKET, THE ULTIMATE GOAL IS TO COMBINE THESE INNOVATIVE DEVICES WITH SILOAM VISION'S EXISTING AI SOFTWARE FOR ROP, CURRENTLY IN CLINICAL TRIALS, TO AN INTEGRATED AI-CAMERA SYSTEM FOR ROP SCREENING AND DIAGNOSIS. LONG-TERM, BOTH THE SLO AND OCT SYSTEMS ARE CLINICALLY SUPERIOR TO ANY EXISTING TECHNOLOGY ON THE MARKET AND MAY HAVE WIDESPREAD IMPACT IN IMPROVE THE CARE OF PEDIATRIC PATIENTS WITH RETINAL DISEASE.

IMPROVE EXISTING AIRPORT

ASSISTANCE TO FIREFIGHTERS GRANT

STAFFING FOR ADEQUATE FIRE AND EMERGENCY RESPONSE (SAFER)

RURAL HEALTH CARE SERVICES OUTREACH GRANT PROGRAM

IMPROVE EXISTING AIRPORT

HIGH-THROUGHPUT PLASTIC MICROFABRICATION TECHNOLOGIES FOR SMART LAB-ON-A-CHIPS

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IMPROVE EXISTING AIRPORT

RURAL HEALTH NETWORK DEVELOPMENT PROGRAM

PURPOSE: REHABILITATE RUNWAY LIGHTING. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT REHABILITATES THE EXISTING RUNWAY 18/36 LIGHTING SYSTEM THAT HAS REACHED THE END OF ITS USEFUL LIFE AND REQUIRES REHABILITATION TO ENHANCE SAFE AIRFIELD OPERATIONS DURING LOW VISIBILITY CONDITIONS. THIS GRANT FUNDS THE FINAL PHASE, WHICH CONSISTS OF CONSTRUCTION. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH SILOAM SPRINGS, ARKANSAS.

IMPROVE EXISTING AIRPORT

IMPROVE EXISTING AIRPORT

PURPOSE: EXTEND/EXPAND TAXILANE. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT EXTENDS EXISTING NORTH HANGAR TAXILANE AN ADDITIONAL 1,100 FEET IN LENGTH TO PROVIDE AIRFIELD ACCESS TO A NON-EXCLUSIVE HANGAR DEVELOPMENT AREA TO BRING THE AIRPORT INTO CONFORMITY WITH CURRENT STANDARDS. THIS GRANT FUNDS PHASE 1, WHICH CONSISTS OF DESIGN. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH SILOAM SPRINGS, ARKANSAS.

PURPOSE: REHABILITATE RUNWAY LIGHTING; REHABILITATE RUNWAY. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT REHABILITATES 4,997 FEET OF THE EXISTING RUNWAY 18/36 TO MAINTAIN THE STRUCTURAL INTEGRITY OF THE PAVEMENT AND TO MINIMIZE FOREIGN OBJECT DEBRIS. THIS PROJECT REHABILITATES THE EXISTING RUNWAY 18/36 LIGHTING SYSTEM THAT HAS REACHED THE END OF ITS USEFUL LIFE AND REQUIRES REHABILITATION TO ENHANCE SAFE AIRFIELD OPERATIONS DURING LOW VISIBILITY CONDITIONS. THIS GRANT FUNDS THE DESIGN PHASE. THIS GRANT FUNDS THE SECOND DESIGN PHASE, WHICH CONSIST OF REHABILITATION OF 4,997 FEET. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH SILOAM SPRINGS, ARKANSAS.

IMPROVE EXISTING AIRPORT C

ASSISTANCE TO FIREFIGHTERS GRANTS

IMPROVE EXISTING AIRPORT

RURAL HEALTH NETWORK DEVELOPMENT PROGRAM

ASSISTANCE TO FIREFIGHTERS GRANT

IMPROVE EXISTING AIRPORT

IMPROVE EXISTING AIRPORT

ASSISTANCE TO FIREFIGHTERS GRANTS

DIRECT COMMUNITY FACILITY LOANS

PURPOSE: AMERICAN RESCUE PLAN ACT AWARDED AS ECONOMIC ASSISTANCE TO ELIGIBLE U.S. AIRPORTS AND ELIGIBLE CONCESSIONS AT THOSE AIRPORTS TO PREVENT, PREPARE FOR, AND RESPOND TO THE COVID-19 PANDEMIC. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS GRANT PROVIDES ECONOMIC RELIEF FUNDS FOR COSTS RELATED TO OPERATIONS, PERSONNEL, CLEANING, SANITIZATION, JANITORIAL SERVICES, DEBT SERVICE PAYMENTS, AND COMBATING THE SPREAD OF PATHOGENS AT THE AIRPORT. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH SILOAM SPRINGS, ARKANSAS.

ASSISTANCE TO FIREFIGHTERS GRANTS

NARCOTICS INTERDICTION EQUIPMENT FUNDING

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IMPROVE EXISTING AIRPORT

THIS GRANT SUPPORTS THE COSTS INCURRED TO IMPLEMENT MEASURES TO RESPOND TO THE NOVEL CORONAVIRUS 2019 (COVID-19), WHICH MAY INCLUDE WORKPLACE SAFETY, MARKET PIVOTS, RETROFITTING FACILITIES, TRANSPORTATION, WORKER HOUSING, AND MEDICAL EXPENSES. IT PROVIDES NEEDED RELIEF TO THE FOOD PROCESSORS, DISTRIBUTORS, FARMERS MARKETS, AND PRODUCERS FOR THEIR COSTS INCURRED BETWEEN JANUARY 27, 2020, THE DATE UPON WHICH THE PUBLIC HEALTH EMERGENCY WAS DECLARED BY THE U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICE (HHS) UNDER SECTION 319 OF THE PUBLIC HEALTH SERVICE ACT, AND DECEMBER 31, 2021. BENEFICIARIES INCLUDE THE EMPLOYEES OF THE FOOD PROCESSORS, DISTRIBUTORS, FARMERS MARKETS, AND PRODUCERS.

COMMUNITY FACILITY GRANTS