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The Ludwig Institute for Cancer Research Ltd is a global non-profit institute committed to improving the under- standing & control of cancer through laboratory and clinical research.
Source: IRS Form 990 (Tax Year 2024)
Source: IRS e-Filed Form 990 (from the IRS e-File system), Tax Year 2024
Total Revenue
▼$63M
Program Spending
84%
of total expenses go to program services
Total Contributions
$61M
Total Expenses
▼$64.3M
Total Assets
$15.6M
Total Liabilities
▼$14.6M
Net Assets
$1.1M
Officer Compensation
→$4.3M
Other Salaries
$3.9M
Investment Income
$42.7K
Fundraising
▼$0
Source: USAspending.gov · Searched by organization name
VA/DoD Awards
$648.8K
VA/DoD Award Count
1
Funding from the Department of Veterans Affairs and/or Department of Defense.
Total Federal Funding
$66.8M
Awards Found
33
Department of Health and Human Services
$16.3M
THE SAN DIEGO EPIGENOME CENTER
Department of Health and Human Services
$14.3M
CENTER FOR MAMMALIAN REGULATORY GENOMICS
Department of Health and Human Services
$9.4M
SAN DIEGO CENTER FOR 4D NUCLEOME RESEARCH
Department of Health and Human Services
$4.6M
FUNCTIONAL ANALYSIS OF T2D ASSOCIATED NON-CODING SNPS
Department of Health and Human Services
$3.1M
MAMMALIAN CENTROMERE ASSEMBLY
Department of Health and Human Services
$2.4M
NEUROFILAMENTS, SOD1 AND MOTOR NEURON DISEASES
Department of Health and Human Services
$2.3M
GENOME-WIDE MAP OF ACTIVE PROMOTERS IN THE MOUSE CELLS
Department of Health and Human Services
$2.3M
NON-CODING VARIANTS PREDISPOSING TO AGE-RELATED MACULAR DEGENERATION
Department of Health and Human Services
$1.1M
REGULATION AND FUNCTIONS OF DNA DAMAGE CHECKPOINT KINASES IN YEAST
Department of Health and Human Services
$998.1K
ALS THERAPIES AND GENOMICS FOR MUTANT TDP-43 AND TLS/FUS
Department of Health and Human Services
$780.4K
INTEGRATIVE ANALYSIS OF HAPLOTYPE-RESOLVED HUMAN EPIGENOME MAPS
Department of Defense
$648.8K
SCREENING THERAPEUTIC AGENTS TARGETING NEUROMUSCULAR JUNCTIONS IN ALS
Department of Health and Human Services
$600K
ORBITRAP FUSION MASS SPECTROMETER
Department of Health and Human Services
$189.7K
DETERMINING THE MOLECULAR ORGANIZATION OF TDP-43 IN LIQUID SPHERICAL ANNULI AND ESTABLISHING A DESIGNER GENE THERAPEUTIC STRATEGY TO DEGRADE TDP-43 AGGREGATES
Department of Health and Human Services
$182.1K
MRNA TARGETS FOR TDP-43 AND FUS/TLS: IDENTIFYING KEY RNA-PROCESSING ERRORS IN ALS
Department of Health and Human Services
$173.6K
STUDYING THE MAMMALIAN REGULATORY CIRCUITS BY DEVELOPING SINGLE-CELL MULTI-OMICS TECHNOLOGIES - PROJECT SUMMARY/ABSTRACT HOW THE IDENTICAL GENOME SEQUENCE PRODUCES DIVERSE CELL TYPES DURING DEVELOPMENT REMAINS A FUNDAMENTAL QUESTION IN BIOLOGY. RECENT TECHNOLOGY ADVANCEMENTS IN SINGLE-CELL GENOMICS PROVIDED EXCELLENT OPPORTUNITIES TO STUDY THE MOLECULAR PROFILES DURING DEVELOPMENT AND IN DISEASE AT UNPRECEDENTED RESOLUTION. HOWEVER, MONITORING INDIVIDUAL MODALITIES FROM SINGLE CELLS AT A TIME RUNS THE RISK OF OBTAINING ONLY PARTIAL PICTURES FROM THE COMPLEX REGULATORY NETWORK. MULTI-MODAL SINGLE-CELL GENOMICS TOOLS WOULD BE DESIRED TO OVERCOME THIS LIMITATION. I RECENTLY INVENTED A METHOD FOR ULTRA-HIGH-THROUGHPUT JOINT ANALYSIS OF OPEN CHROMATIN AND TRANSCRIPTOME FROM THE SAME SINGLE CELLS (PAIRED-SEQ) AND DEMONSTRATED ITS POTENTIAL FOR COMPREHENSIVE INVESTIGATIONS OF THE CELL- TYPE-SPECIFIC REGULATORY PROGRAMS FROM HETEROGENOUS BRAIN TISSUES. IN THIS K99/R00 APPLICATION, I PROPOSE TO FURTHER DEVELOP A SET OF NEW SINGLE-CELL MULTI-OMICS TOOLS TO STUDY THE DYNAMIC AND CELL-TYPE-SPECIFIC REGULATORY CIRCUITS DURING MAMMALIAN DEVELOPMENT. I WILL IMPROVE THE SENSITIVITIES AND COVERAGES OF PAIRED-SEQ AND DEVELOP A COMPUTATIONAL METHOD FOR SINGLE-CELL MULTI-OMICS ANALYSIS FROM THE PHENOTYPIC LEVEL (AIM1). SUBSEQUENTLY, I WILL FURTHER DEVELOP A METHOD FOR HIGH-THROUGHPUT SINGLE-CELL JOINT ANALYSIS OF HISTONE MODIFICATIONS/TRANSCRIPTION FACTORS BINDING WITH GENE EXPRESSION (PAIRED-TAG) FOR ANALYSIS OF MOLECULAR PROGRAMS FROM THE MECHANISTIC LEVEL (AIM2). FINALLY, I WILL APPLY THESE TECHNOLOGIES TO STUDY THE DYNAMIC AND CELL-TYPE-SPECIFIC MOLECULAR PROGRAMS IN MAMMALIAN DEVELOPING GERM CELLS, AND TO IDENTIFY AND VALIDATE NOVEL REGULATORS DURING THIS PROCESS (AIM3). OVERALL, THE RESULTS FROM THIS PROPOSAL WILL PROVIDE NEW TECHNOLOGIES FOR THE STUDY OF EPIGENETIC PROGRAMS IN COMPLEX TISSUES AND DURING DEVELOPMENT AT SINGLE-CELL RESOLUTION, AND PROVIDING MORE COMPLETE VIEWS OF THE GENE REGULATORY CIRCUITS DURING MAMMALIAN GERM CELL DEVELOPMENT. MY CAREER GOAL IS TO LEAD AN INDEPENDENT RESEARCH GROUP FOCUSING ON INTEGRATING NOVEL EXPERIMENTAL AND COMPUTATIONAL TECHNOLOGIES TO UNDERSTAND THE UNDERLYING PRINCIPLES CONTROLLING MAMMALIAN DEVELOPMENT. DURING THE K99 PHASE, I WILL CONTINUE TO RECEIVE EXPERIMENTAL AND COMPUTATIONAL TRAINING FROM MY POSTDOCTORAL MENTOR DR. REN AND COLLABORATORS/ADVISORY COMMITTEE AT UC SAN DIEGO AND THE SALK INSTITUTE. THE RIGOROUS MENTORED SUPPORT AND RESULTS OBTAINED IN THE K99 PHASE WILL FACILITATE MY TRANSITION TO AN INDEPENDENT INVESTIGATOR IN THE R00 PHASE AND LAY THE FOUNDATION FOR MY FUTURE CAREER.
Department of Health and Human Services
$165K
CELL DIVISION ERRORS AS A MECHANISM DRIVING MASSIVE GENOMIC REARRANGEMENTS
Department of Health and Human Services
$162.5K
DISSECTING THE CIS-REGULATORY ROLES OF TRANSPOSABLE ELEMENTS IN HUMAN CANCERS
Department of Health and Human Services
$150.4K
MECHANISMS OF GLIOMA RESISTANCE TO EGFR INHIBITION
Department of Health and Human Services
$133K
MECHANISMS OF MISMATCH REPAIR MEDIATED CELL DEATH AFTER ALKYLATING AGENT EXPOSURE
Department of Health and Human Services
$117.6K
THE ROLE OF S. CEREVISIAE MLH1-PMS1 DURING MMR STRAND DISCRIMINATION
Department of Health and Human Services
$115K
MECHANISMS OF C9ORF72 HEXANUCLEOTIDE REPEAT EXPANSION CAUSED NEURODEGENERATION IN ALS AND FTD
Department of Health and Human Services
$114.4K
DETERMINE HOW LOSS-OF-FUNCTION OF THE TBK1 KINASE CAUSES AGE-DEPENDENT DEGENERATION IN FRONTOTEMPORAL DEMENTIA
Department of Health and Human Services
$113.1K
THE ROLE OF CENP-A AND CENTROMERE COMPONENTS IN DNA REPAIR
Department of Health and Human Services
$103.8K
EXPLORATION OF GENOME STABILITY AS A THERAPEUTIC TARGET IN CANCER
Department of Health and Human Services
$101.4K
UNDERSTANDING THE ROLE OF PCNA IN DNA MISMATCH REPAIR SUBPATHWAYS
Department of Health and Human Services
$100.2K
ROLES FOR TDP-43 AND FUS IN ALS USING MOTOR NEURONS FROM EMBRYONIC STEM CELLS
Department of Health and Human Services
$96.9K
TRANSCRIPTIONAL REGULATION OF THE DNA DAMAGE RESPONSE BY SWI4/6 PHOSPHORYLATION
Department of Health and Human Services
$74.2K
GENETIC ANALYSIS OF EGFRVIII-INDEPENDENT GLIOBLASTOMA MAINTENANCE
Department of Health and Human Services
$73.1K
A NOVEL APPROACH TO TREATING GLIOBLASTOMA THROUGH ACTIVATION OF THE LIVER X RECEP
Department of Health and Human Services
$61K
DETERMINING HOW THE CHROMOSOME PASSENGER COMPLEX AND POLO-LIKE KINASE 1 CONTROL CYTOKINESIS
Department of Health and Human Services
$53.3K
PATHOGENIC MECHANISMS OF C9ORF72 GGGGCC REPEAT EXPANSIONS IN AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORALDEMENTIA AND DEVELOPMENT OF THERAPEUTIC
Source: Federal Audit Clearinghouse (fac.gov)
Total Audits
8
Clean Audits
8
Material Weakness
No
Noncompliance Issues
No
| Year | Status | Financial Report | Federal Expenditure | Low Risk | Accepted |
|---|---|---|---|---|---|
| 2023 | Clean | Unmodified (Clean) | $792.6K | Yes | 2024-05-24 |
| 2022 | Clean | Unmodified (Clean) | $3.3M | Yes | 2023-05-10 |
| 2021 | Clean | Unmodified (Clean) | $4.7M | Yes | 2022-05-10 |
| 2020 | Clean | Unmodified (Clean) | $5.9M | Yes | 2021-05-04 |
| 2019 | Clean | Unmodified (Clean) | $9.3M | Yes | 2020-05-06 |
| 2018 | Clean | Unmodified (Clean) | $9M | Yes | 2019-06-10 |
| 2017 | Clean | Unmodified (Clean) | $11.8M | Yes | 2018-05-17 |
| 2016 | Clean | Unmodified (Clean) | $11.7M | Yes | 2017-08-01 |
Financial Report
Unmodified (Clean)
Federal Expenditure
$792.6K
Financial Report
Unmodified (Clean)
Federal Expenditure
$3.3M
Financial Report
Unmodified (Clean)
Federal Expenditure
$4.7M
Financial Report
Unmodified (Clean)
Federal Expenditure
$5.9M
Financial Report
Unmodified (Clean)
Federal Expenditure
$9.3M
Financial Report
Unmodified (Clean)
Federal Expenditure
$9M
Financial Report
Unmodified (Clean)
Federal Expenditure
$11.8M
Financial Report
Unmodified (Clean)
Federal Expenditure
$11.7M
Tax Year 2024 · Source: IRS e-Filed Form 990Schedule J available
Individuals serving as officers, directors, or trustees of the organization.
| Name | Title | Hrs/Wk | Compensation | Related Orgs | Other |
|---|
Source: IRS Publication 78, Auto-Revocation List & e-Postcard Data
Tax-deductible contributions: Yes
Deductibility code: PC
Sources: IRS e-Filed Form 990 (XML) & ProPublica Nonprofit Explorer
Scroll →
| Year | Revenue | Contributions | Expenses | Assets | Net Assets |
|---|---|---|---|---|---|
| 2024IRS e-File | $63M | $61M | $64.3M | $15.6M | $1.1M |
| 2023IRS e-File | $72.9M | $70.2M | $71.4M | $19.3M | $2.7M |
| 2022 | $102.4M | $90.7M | $107.9M | $21.6M | $2M |
| 2021 | $89.3M |
Sources: ProPublica Nonprofit Explorer & IRS e-File Index
| Tax Year | Form Type | Source | Documents |
|---|---|---|---|
| 2024 | 990 | IRS e-File | PDF not yet published by IRSView Filing → |
| 2023 | 990 | DataIRS e-File | PDF not yet published by IRSView Filing → |
| 2022 | 990 | DataIRS e-File |
Financial data: IRS e-Filed Form 990 (Tax Year 2024)
Leadership & compensation: IRS e-Filed Form 990, Part VII (Tax Year 2024)
Federal grants: USAspending.gov (live)
Organization info: IRS Business Master File
Tax-deductibility: IRS Publication 78
| Total |
|---|
| Dr Chi Van Dang | Dir, Sci. Dir, CEO (from 7/24) | 50 | $1.1M | $0 | $73.6K | $1.2M |
| Dr Jonathan Skipper | President (from 7/24) | 45 | $789.2K | $0 | $73.6K | $862.8K |
| Edward A Mcdermott Jr | Dir, Board Chair (from 7/24) | 44 | $14.8K | $604.1K | $51.8K | $670.7K |
| Thomas Baenninger | Chief Financial Officer | 40 | $546.1K | $0 | $116.7K | $662.8K |
| Patrice Morin | Deputy Scient. Dir. | 45 | $406.2K | $0 | $75.3K | $481.5K |
Dr Chi Van Dang
Dir, Sci. Dir, CEO (from 7/24)
$1.2M
Hrs/Wk
50
Compensation
$1.1M
Related Orgs
$0
Other
$73.6K
Dr Jonathan Skipper
President (from 7/24)
$862.8K
Hrs/Wk
45
Compensation
$789.2K
Related Orgs
$0
Other
$73.6K
Edward A Mcdermott Jr
Dir, Board Chair (from 7/24)
$670.7K
Hrs/Wk
44
Compensation
$14.8K
Related Orgs
$604.1K
Other
$51.8K
Thomas Baenninger
Chief Financial Officer
$662.8K
Hrs/Wk
40
Compensation
$546.1K
Related Orgs
$0
Other
$116.7K
Patrice Morin
Deputy Scient. Dir.
$481.5K
Hrs/Wk
45
Compensation
$406.2K
Related Orgs
$0
Other
$75.3K
Highest compensated employees who are not officers or directors.
| Name | Title | Hrs/Wk | Compensation | Related Orgs | Other | Total |
|---|---|---|---|---|---|---|
| Yang Shi | Group Leader | 10 | $467.7K | $0 | $62.9K | $530.6K |
| George Coukos | Branch Director | 40 | $416.5K | $0 | $85.3K | $501.8K |
| Xin Lu | Branch Director | 10 | $408.3K | $0 | $54.7K | $463K |
Yang Shi
Group Leader
$530.6K
Hrs/Wk
10
Compensation
$467.7K
Related Orgs
$0
Other
$62.9K
George Coukos
Branch Director
$501.8K
Hrs/Wk
40
Compensation
$416.5K
Related Orgs
$0
Other
$85.3K
Xin Lu
Branch Director
$463K
Hrs/Wk
10
Compensation
$408.3K
Related Orgs
$0
Other
$54.7K
Members of the governing board. Board members often serve without compensation.
| Name | Title | Hrs/Wk | Compensation | Related Orgs | Other | Total |
|---|---|---|---|---|---|---|
| Alexandra Johnson | Director | 2 | $11.3K | $30K | $0 | $41.3K |
| Dr Nancy Ellen Davidson | Director | 2 | $11.3K | $30K | $0 | $41.3K |
| Jedd Wolchok | Director | 2 | $11.3K | $85K | $0 | $96.2K |
| John D Gordan Iii | Director | 2 | $11.3K | $85K | $0 | $96.2K |
| John L Notter | Dir, Board Chair (end 6/24) | 8 | $15.4K | $100K | $0 | $115.3K |
| Judge Barbara S Jones |
Alexandra Johnson
Director
$41.3K
Hrs/Wk
2
Compensation
$11.3K
Related Orgs
$30K
Other
$0
Dr Nancy Ellen Davidson
Director
$41.3K
Hrs/Wk
2
Compensation
$11.3K
Related Orgs
$30K
Other
$0
Jedd Wolchok
Director
$96.2K
Hrs/Wk
2
Compensation
$11.3K
Related Orgs
$85K
Other
$0
| $60.9M |
| $90M |
| $25.8M |
| $3.9M |
| 2020 | $77.6M | $74.5M | $72.9M | $31.5M | $5M |
| 2019 | $80.5M | $73.4M | $81.5M | $32.1M | $1.8M |
| 2018 | $66.6M | $63.4M | $83.7M | $36M | $5.1M |
| 2017 | $101.4M | $96.4M | $95.4M | $56.1M | $22.9M |
| 2016 | $95.8M | $89.6M | $99.3M | $51.3M | $15.3M |
| 2015 | $95.6M | $85.6M | $96.2M | $51.1M | $20.1M |
| 2014 | $107.4M | $96.8M | $101M | $45.5M | $22.3M |
| 2013 | $106.8M | $98.8M | $108.1M | $44.1M | $16.2M |
| 2012 | $123.2M | $114.8M | $114M | $46.8M | $17.4M |
| 2011 | $124.8M | $115.7M | $121.1M | $46.8M | $8.1M |
PDF not yet published by IRSView Filing → |
| 2021 | 990 | Data |
| 2020 | 990 | Data |
| 2019 | 990 | Data |
| 2018 | 990 | Data |
| 2017 | 990 | Data |
| 2016 | 990 | Data |
| 2015 | 990 | Data |
| 2014 | 990 | Data |
| 2013 | 990 | Data |
| 2012 | 990 | Data |
| 2011 | 990 | Data |
| 2010 | 990 | — |
| 2009 | 990 | — |
| 2008 | 990 | — |
| 2007 | 990 | — |
| 2006 | 990 | — |
| 2005 | 990 | — |
| 2004 | 990 | — |
| 2003 | 990 | — |
| 2002 | 990 | — |
| 2001 | 990 | — |
| Michael Macaranas | Branch Administrator(end 4/24) | 40 | $387.2K | $0 | $23.1K | $410.2K |
| Alexander Borissov | Sec. To Board, Internal Audit | 37 | $287.4K | $0 | $76.2K | $363.5K |
| Richard White | Group Leader | 10 | $272.4K | $0 | $78K | $350.4K |
| Gerd Ritter | Technology Development Manager | 40 | $268K | $0 | $65.6K | $333.6K |
Michael Macaranas
Branch Administrator(end 4/24)
$410.2K
Hrs/Wk
40
Compensation
$387.2K
Related Orgs
$0
Other
$23.1K
Alexander Borissov
Sec. To Board, Internal Audit
$363.5K
Hrs/Wk
37
Compensation
$287.4K
Related Orgs
$0
Other
$76.2K
Richard White
Group Leader
$350.4K
Hrs/Wk
10
Compensation
$272.4K
Related Orgs
$0
Other
$78K
Gerd Ritter
Technology Development Manager
$333.6K
Hrs/Wk
40
Compensation
$268K
Related Orgs
$0
Other
$65.6K
| Director |
| 2 |
| $11.3K |
| $30K |
| $0 |
| $41.3K |
| Nicolas Killen | Director | 2 | $11.3K | $30K | $0 | $41.3K |
| Xing Chen | Director (from 7/24) | 1 | $0 | $1M | $186.5K | $1.2M |
John D Gordan Iii
Director
$96.2K
Hrs/Wk
2
Compensation
$11.3K
Related Orgs
$85K
Other
$0
John L Notter
Dir, Board Chair (end 6/24)
$115.3K
Hrs/Wk
8
Compensation
$15.4K
Related Orgs
$100K
Other
$0
Judge Barbara S Jones
Director
$41.3K
Hrs/Wk
2
Compensation
$11.3K
Related Orgs
$30K
Other
$0
Nicolas Killen
Director
$41.3K
Hrs/Wk
2
Compensation
$11.3K
Related Orgs
$30K
Other
$0
Xing Chen
Director (from 7/24)
$1.2M
Hrs/Wk
1
Compensation
$0
Related Orgs
$1M
Other
$186.5K