Fred Hutchinson Cancer Research Center

LEADERSHIP GROUP FOR A GLOBAL HIV VACCINE CLINICAL TRIALS NETWORK

LEADERSHIP FOR HIV/AIDS CLINICAL TRIALS NETWORKS; MICROBICIDE TRIALS NETWORK

HVTN LABORATORY PROGRAM

LEADERSHIP FOR HIV/AIDS CLINICAL TRIALS NETWORKS; HIV VACCINE TRIALS NETWORK

SOUTHWEST ONCOLOGY GROUP STATISTICAL CENTER

ELICITING VRC01-LIKE BNABS BY SPECIFICALLY DESIGNED ENV IMMUNOGENS

PERSONAL PROTECTIVE EQUIPMENT FOR RESOURCES FOR COVID-19 RELATED VACCINE AND TREATMENT CLINICAL TRIALS AND CLINICAL STUDIES

BARRETT'S ESOPHAGUS: PREDICTORS OF PROGRESSION

TARGETED MODIFICATION OF HOST AND PROVIRAL DNA TO TREAT LATENT HIV INFECTION

LEADERSHIP FOR HIV/AIDS CLINICAL TRIALS NETWORKS; HIV PREVENTION TRIALS NETWORK

CANCER IMMUNOTHERAPY TRIALS NETWORK CENTRAL OPERATIONS AND STATISTICAL CENTER

THERAPY OF LYMPHOMA/LEUKEMIA WITH MONOCLONAL ANTIBODIES

PERSONAL PROTECTIVE EQUIPMENT FOR RESOURCES FOR COVID-19 RELATED VACCINE AND TREATMENT CLINICAL TRIALS AND CLINICAL STUDIES - PROJECT SUMMARY/ABSTRACT PLANNED COVID-19 VACCINE TRIALS REQUIRE SCREENING, ENROLLING, AND FOLLOWING OVER 150,000 VOLUNTEER STUDY PARTICIPANTS OVER 24 MONTHS. THE TRIAL PARTICIPANTS WILL BE SELECTED BASED ON THEIR RISK OF COVID-19 INFECTION, WITH TRIAL PARTICIPANTS COMING FROM SETTINGS WITH HIGH RATES OF COMMUNITY TRANSMISSION, GROUPS WITH HIGHER RISK OF PROGRESSION TO SYMPTOMATIC DISEASE, OR BOTH. STUDY STAFF WORKING ON COVID-19 VACCINE TRIALS WILL NEED TO INTERACT WITH TRIAL PARTICIPANTS DURING REGULAR VISITS AS WELL AS CONDUCTING IN-PERSON ASSESSMENTS OF ALL VACCINE TRIAL PARTICIPANTS WITH SYMPTOMS THAT COULD BE DUE TO COVID-19 DISEASE. THIS WILL RESULT IN CLOSE CONTACT BETWEEN STUDY STAFF AND HIGH-RISK PARTICIPANTS OR INFECTED PARTICIPANTS. AS A RESULT, STUDY STAFF NEED TO ACCESS A REGULAR SUPPLY OF PERSONAL PROTECTIVE EQUIPMENT (PPE), INCLUDING SURGICAL MASKS, FACE SHIELDS OR GOGGLES, GOWNS, AND DISPOSABLE GLOVES, AS WELL AS THE ABILITY TO SANITIZE HANDS FREQUENTLY. THIS COMBINATION OF PPE WILL BE USED DURING ALL RISKY INTERACTIONS WITH STUDY PARTICIPANTS, SUCH AS DURING NASAL SWAB COLLECTION AND DURING EVALUATION OF PARTICIPANTS FOR POSSIBLE STUDY ENDPOINTS, INCLUDING SYMPTOMATIC COVID-19 DISEASE. IN ADDITION, ALL STAFF WILL NEED TO WEAR SURGICAL FACE MASKS DURING AND THROUGHOUT THEIR NORMAL WORKDAY IN THE HEALTH CARE SETTING OR ON SITE FOR MOBILE STUDY SATELLITE SITES. WITHOUT APPROPRIATE PPE, HEALTH CARE WORKERS ARE VULNERABLE TO INFECTION WITH COVID-19, AS WELL AS PASSIVELY TRANSMITTING TO PERSONS WITH WHOM THEY ARE IN CLOSE PHYSICAL CONTACT. ACCESS TO ADEQUATE PPE IS A CRITICAL COMPONENT OF THE SAFE AND EFFECTIVE CONDUCT OF COVID-19 VACCINE TRIALS, AND WILL ENABLE ACCURATE DETERMINATION OF THE STUDY ENDPOINTS, ESPECIALLY SYMPTOMATIC COVID- 19 DISEASE.

PACIFIC OVARIAN CANCER RESEARCH CONSORITUM

MENOPAUSAL SYMPTOMS INITIATIVE-FINDING LASTING ANSWERS FOR SWEATS AND HOT FLASHES

CENTER FOR STATISTICS AND QUANTITATIVE INFECTIOUS DISEASES

DETECTION OF COLORECTAL CANCER SUSCEPTIBILITY LOCI USING GENOME-WIDE SEQUENCING

NOTCH-MEDIATED EXPANSION OF CORD BLOOD PROGENITORS FOR STEM CELL TRANSPLANT

THE PATHOGENESIS OF FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY

WOMEN'S HEALTH INITIATIVE CANCER SURVIVOR COHORT

SEATTLE CANCER CONSORTIUM BREAST SPORE

LEADERSHIP FOR HIV/AIDS CLINICAL TRIALS NETWORKS; MICROBICIDE TRIALS NETWORK

TREC COORDINATION CENTER

EPIDEMIOLOGY OF PUTATIVE GENUINE GENETIC VARIANT: THE WOMEN'S HEALTH INTIATIVE

WHOLE GENOME ASSOCIATION ANALYSIS OF HEMATOPOIETIC CELL TRANSPLANT (HCT) OUTCOME

RADIATION DOSE-DEPENDENT INTERVENTIONS

UNDERSTANDING AND PREVENTING BREAST CANCER DISPARTIES IN LATINAS

DATA CENTER CORE CONSOLIDATION

HPV: BIOLOGY, CLINICAL SIGNIFICANCE AND EPIDEMIOLOGY

MECHANISMS AND COFACTORS OF HIV TRANSMISSION TO WOMEN

STEM CELL TRANSPLANTATION: BASIC/CLINICAL RESEARCH

MOLECULAR ANALYSIS OF EUKARYOTIC TRANSCRIPTION

EXPANSION OF CARDIAC AND HEMATOPOIETIC PREGENITORS BY WNT AND NOTCH

CONTROLLING HEMATOPOIETIC LINEAGE COMMITMENT FROM ESC TO PLATELETS

BARRETT'S AND ESOPHAGEAL ADENOCARCINOMA GENETIC SUSCEPTIBILITY STUDY (BEAGESS)

LATE EFFECTS OF TREATMENT IN WILMS TUMOR SURVIVORS AND OFFSPRING

MOLECULAR CONTROL OF HEMATOPOIETIC STEM CELL FATE

GENOME-WIDE ASSOCIATION STUDY OF NONSYNONYMOUS SNPS IN COLON CANCER

PROSPR STATISTICAL COORDINATING CENTER (PSCC)

EARLY INFECTION IN WOMEN EXPOSED MUCOSALLY TO HIV-1

CORE CENTER OF EXCELLENCE IN HEMATOLOGY

MSFLASH: LIVING A HEALTHY MENOPAUSE

FUNCTION OF HUMAN & MOUSE BETA-GLOBIN LOCUS CONTROL REGIONS

MAINTENANCE OF GENE EXPRESSION IN THE RED CELL LINEAGE

THE COLON CANCER FAMILY REGISTRY: SEATTLE

HIV TESTING AND TREATMENT TO PREVENT ONWARD HIV TRANSMISSION AMONG HIGH-RISK MSM

IMPROVING OUTCOME FOR HEMORRHAGIC SHOCK USING INHIBITORS OF OXIDATIVE PHOSPHORYLATION

MECHANISMS OF EUKARYOTIC TRANSCRIPTION ACTIVATION

REGULATION OF CELL GROWTH AND PROLIFERATION BY MYC

IMMUNOBIOLOGY OF TOLERANCE FOLLOWING ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATIO

MECHANISMS AND FUNCTIONS OF ATP-DEPENDENT CHROMATIN REMODELING

MOLECULAR ANALYSIS OF HOTSPOTS OF GENETIC RECOMBINATION

CONTAINING BIOTERROIST AND EMERGING INFECTIOUS DISEASES

A RANDOMZIED PHASE II TRIAL OF CMV PREVENTION IN ACUTE LUNG INJURY

MONITORING THE DEVELOPMENT OF ANTI-ENV ABS DURING HIV INFECTION

DISCOVERY AND VERIFICATION OF NOVEL BIOMARKERS OF COLORECTAL CANCER RECURRENCE

TARGETED THERAPY OF ALL WITH GENE-MODIFIED CENTRAL MEMORY T CELLS

THE ROLE OF UNCULTIVATED BACTERIA IN BACTERIAL VAGINOSIS

PROACTIVE SMOKING CESSATION FOR ADOLESCENTS

MODELING PROSTATE CANCER CONTROL: PREVENTION SCREENING TREATMENT FOLLOWUP CARE

MODELING TO IMPROVE PROSTATE CANCER OUTCOMES ACROSS DIVERSE POPULATIONS

MECHANISMS OF ENERGY BALANCE AND CANCER PREVENTION

PCPT AND SELECT COHORTS: CORE INFRASTRUCTURE SUPPORT FOR CANCER RESEARCH

HIV HOST-CELL INTERACTIONS

STATISTICAL METHODS FOR MEDICAL STUDIES

OBJECTIVE PHYSICAL ACTIVITY AND CARDIOVASCULAR HEALTH IN WOMEN AGED 80 AND OLDER

MEASUREMENT OF CANCER-ASSOCIATED BIOMARKER PROTEINS IN COMPLEX BIOLOGICAL SAMPLES

INTERACTIONS OF HPV ONCOGENES WITH THE P53 PATHWAY

EPIDEMIOLOGY OF THE FOUR MOST FREQUENT CANCERS FOLLOWING BREAST CANCER

USE OF DEPO-MEDROXYPROGESTERONE ACETATE AND RISK OF PREMENOPAUSAL BREAST CANCER

CENTER FOR HISPANIC HEALTH PROMOTION: REDUCING CANCER DISPARITIES

ROLE OF THE PERIVASCULAR MICROENVIRONMENT IN PRIMARY AND METASTATIC BRAIN TUMORS

ADVANCING OUR UNDERSTANDING OF THE ETIOLOGIES AND MUTATIONAL LANDSCAPES OF BASAL-LIKE, LUMINAL A, AND LUMINAL B BREAST CANCERS

METHODS FOR EVALUATING VACCINE EFFICACY

BREAST CANCER RISK AND MOLECULAR CHANGE AFTER CHERNOBYL

EDRN:DATA MANAGEMENT AND COORDINATING CENTER

TOWARDS A MORE RELEVANT MODEL OF HIV INFECTION

HPV CAPSID ANTIBODIES

TRANSLATIONAL CONTROL OF CYTOMEGALOVIRUS GENE EXPRESSION

PROFILING CANCER NEOANTIGEN REPERTOIRES AND VALIDATING IMMUNOTHERAPY TARGETS

MYC ONCOPROTEIN FUNCTION

PHYSICAL ACTIVITY TO IMPROVE CV HEALTH IN OLDER WOMEN: A PRAGMATIC TRIAL -- DCC

TARGETING TUMOR DORMANCY TO PREVENT METASTATIC RELAPSE

P3IK SIGNALING AND BIOLOGY OF THERAPEUTIC RESPONSE IN BRAIN AND PROSTATE TUMORS

AN INTEGRATED COMPUTATIONAL AND FUNCTIONAL GENOMICS DISCOVERY ENGINE FOR PRECLINI

DEFINING THE INFANT IMMUNE RESPONSE TO HIV

BIOLOGIC DETERMINANTS OF THE NATURAL HISTORY OF AIDS-DEFINING CANCERS IN UGANDA

TUMOR MAINTENANCE AND DEVELOPMENT IN MOUSE MODELS

RNA AS A HORMONE: SYSTEMIC SIGNALING IN MAMMALS VIA CIRCULATING, CELL-FREE SMALL

IMPROVING OUTCOME IN ISCHEMIA AND ISCHEMIA REPERFUSION INJURY USING ELEMENTAL REDUCING AGENTS

CENTER FOR COMPARATIVE EFFECTIVENESS RESEARCH IN CANCER GENOMICS - CANCERGEN

PHOSPHORYLATION OF GAP JUNCTION PROTEINS

LINEAGE DETERMINATION IN MUSCLE

CHLOROTOXIN AS A TARGETING AGENT FOR CANCER THERAPIES

TAMOXIFEN & SECOND BREAST CANCER: EPIDEMIOLOGY/PATHOLOGY

MECHANISM OF INCREASE GENOMIC INSTABILITY IN AGING YEAST

ENGRAFTMENT AND IN VIVO SELECTION OF HIV-PROTECTED STEM CELLS

IMMUNE MEDIATED DISORDERS AFTER ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTS (HCT)

ROLE OF THE MICROBIOME IN HIV VACCINE INDUCED HETEROGENEITY

TELEPHONE-DELIVERED ACCEPTANCE AND COMMITMENT THERAPY FOR SMOKING CESSATION

CTRIP:NOTCH-MEDIATED EXPANSION OF CORD BLOOD PROGENITORS FOR CORD BLOOD TRANSPLAN

PRECLINICAL GENE THERAPY STUDIES IN CANINE MUSCULAR DYSTROPHY

INTERNET STUDIES TO ENHANCE LONG TERM SURVIVORSHIP AFTER HEMATOLOGIC MALIGNANCY

RANDOMIZED TRIAL OF WEB-DELIVERED ACCEPTANCE THERAPY FOR SMOKING CESSATION

EVALUATION OF PLURIPOTENT STEM CELL-DERIVED BLOOD CELLS IN NONHUMAN PRIMATE MODEL

ESOPHAGEAL CANCER FROM CELLS TO POPULATION: A MULTISCALE APPROACH

IMMUNIZATION OF ORAL MUCOSA FOR INDUCTION OF RECTAL AND GENITAL MUCOSAL IMMUNITY

MOLECULAR MECHANISMS OF GENETIC RECOMBINATION

GUT MICROBIOTA AND COLONIC GENE EXPRESSION: A LIGRAN TRIAL IN HUMANS

EXONIC VARIANTS AND THEIR RELATION TO COMPLEX TRAITS IN MINORITIES OF THE WHI

BIOLOGY AND PROGNOSTIC IMPLICATIONS OF FLT3 MUTATIONS IN AML

DEEP SEQUENCING FOR MINIMAL RESIDUAL DISEASE DETECTION IN ACUTE LYMPHOBLASTIC LEU

EMPLOYING THE MYC TRANSCRIPTIONAL NETWORK TO REVEAL ONCOGENIC PATHWAYS

WHOLE GENOME SEQUENCE ANALYSIS OF ISCHEMIC STROKE IN THE WOMEN'S HEALTH INITIATIVE

AFFINITY BASED STRATEGIES TO FAST TRACK DEVELOPMENT OF COLON CANCER BIOMARKERS

LEUKOCYTE TELOMERE LENGTH AND CARDIOVASCULAR DISEASE IN JACKSON HEART STUDY

RANDOMIZED TRIAL OF AN INNOVATIVE SMARTPHONE INTERVENTION FOR SMOKING CESSATION

STIMULATION OF TUMORIGENESIS BY NKG2D

ACCEPTANCE & COMMITMENT THERAPY FOR SMOKING CESSATION

HUTCHINSON CENTER AS LEAD ACADEMIC PARTICIPATING SITE (U10)

A PROSPECTIVE STUDY OF COLORECTAL CANCER: ONE-CARBON METABOLISM AND INFLAMMATION

BIOCONDUCTOR: AN OPEN COMPUTING RESOURCE FOR GENOMICS

THE STATISTICAL AND COMPUTATIONAL ANALYSIS OF FLOW CYTOMETRY DATA

PAVING THE WAY FOR A NOVEL THERAPEUTIC APPROACH TO COMBAT HIV

SINGLE-CELL METHODS FOR ANALYSIS OF CLONAL HETEROGENEITY AND EVOLUTION IN CANCER

HUMAN AND BACTERIAL MOLECULAR PATHWAYS IN CANCER RISK: MODULATION BY DIET

CD8+T CELL IMMUNITY TO CYTOMEGALOVIRUS

PROMISS - PROSTATE MODELING TO IDENTIFY SURVEILLANCE STRATEGIES

ORAL CANCER: MOLECULAR PROFILES & CLINICAL OUTCOMES

CROSS-SPECIES NETWORK APPROACH TO PREDICT EPISTATIC CANCER SUSCEPTIBILITY GENES

DEVELOPMENT OF SAFE AND EFFICIENT GENE THERAPY STRATEGIES FOR HEMOGLOBINOPATHIES

BIOMARKERS FOR EARLY DETECTION OF CLINICALLY RELEVANT PROSTATE CANCER: A MULTI-INSTITUTIONAL VALIDATION TRIAL

CHARACTERIZATION OF HIV-1 ANTIBODY RESPONSES IN CHRONICALLY INFECTED WOMEN

REGULATION OF CENTROMERIC CHROMATIN

NAIVE T CELL DEPLETION TO PREVENT GRAFT-VERSUS-HOST DISEASE

INFRASRUCTURE SUPPORT AND DATA ENHANCEMENTS FOR THE CARET BIOREPOSITORY

NOVEL BIOMARKERS TO RISK-STRATIFY AML PATIENTS WITH NPM1^POS/FLT3-IT^NEG GENOTYPE

PARTNERSHIP FOR A HISPANIC DIABETES PREVENTION PROGRAM

CELLULAR COOPERATION AND CHEATING: AN EXPERIMENTAL AND MATHEMATICAL ANALYSIS

INTEGRATED SENSOR TECHNOLOGY FOR REAL-TIME RECORDING OF FOOD INTAKE

NOVEL PATHOGEN ASSOCIATED CANCERS (PQ12)

STATISTICAL METHODS FOR MEDICAL TESTS AND BIOMARKERS

THE COLONIC MICROBIOTA AND IMMUNITY AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION

STATISTICAL METHODS FOR PROSPECTIVE EVALUATION OF BIOMARKERS

EPIDEMIOLOGIC FACTORS AND SURVIVAL BY MOLECULAR SUBTYPES OF OVARIAN CANCER

A COHORT STUDY OF SESSILE SERRATED POLYPS AND SUBSEQUENT COLORECTAL NEOPLASIA

GWAS OF HORMONE TREATMENT AND CVD AND METABOLIC OUTCOMES IN THE WHI

TOGETHER WE STRIDE (STRATEGIZING TOGETHER RELEVANT INTERVENTIONS FOR DIET AND EXERCISE)

MECHANISMS OF CELL CYCLE ASSOCIATED NEOPLASIA

IMPROVING ENGRAFTMENT OF HEMATOPOIETIC STEM CELL GENE THERAPY

MOLECULAR CORRELATES OF OUTCOMES IN CLINICAL TRIALS OF COLON CANCER

NIGHT SHIFT WORK AND HORMONE LEVELS IN MEN

LAGLIDADG DELIVERY AND GENE REPAIR IN CANINE HEMATOPOIETIC STEM CELLS (7 OF 11)

STATISTICAL METHODS FOR ADHERENCE ISSUES IN HIV PREVENTION RESEARCH

IMMUNE MEDIATED DISORDERS AFTER ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTS (HCT)

MECHANISMS OF ENVIRONMENTAL AND NUCLEAR AND MITOCHONDRIAL MUTAGENESIS

DISCOVERY AND OPTIMIZATION OF AML PROGNOSTIC BIOMARKERS

HYBRID PLASMA MARKERS THAT COMPLEMENT CT IMAGING FOR EARLY LUNG CANCER DETECTION

MICROCHIMERISM AS ALLOIMMUNITY

SEATTLE VACCINE TRIALS UNIT

THE IMPACT OF PRENATAL EXPOSURE TO PERSISTENT ORGANIC POLLUTANTS ON KINETICS OF IMMUNE RESPONSE TO VACCINES AND SERO-PROTECTION IN INFANTS

TELOMERES AND LUNG CANCER INCIDENCE AND SURVIVAL

SHWACHMAN-DIAMOND SYNDROME: MOLECULAR PATHOGENESIS

EPIGENOMIC PROFILING OF HISTONE TURNOVER KINETICS IN MAMMALIAN CELLS

STATISTICAL METHODS FOR COMBINATION HIV PREVENTION APPROACHES

USE OF SELENIDE TO IMPROVE OUTCOME IN REPERFUSION INJURY

IMPROVING OUTCOMES ASSESSMENT IN CHRONIC GVHD

DISCOVERING TISSUE-SPECIFIC BIOMARKERS OF RADIATION INJURY IN SILAC-LABELED MICE

ESTIMATING OVERDIAGNOSIS IN CANCER SCREENING STUDIES

NORMAL AND NEOPLASTIC REGULATION OF CYCLIN E

SRC FAMILY KINASES AND CELL GROWTH REGULATION

DEVELOPMENT OF NOVEL AIDS GENE THERAPY STRATEGIES IN THE MACAQUE SHIV MODEL

INVESTIGATING CREBBP AS A TUMOR SUPPRESSOR IN SMALL CELL LUNG CANCER

MYC-DEPENDENT LOSS OF SPLICING FIDELITY IN GLIOBLASTOMA MULTIFORME

MINIMIZING MASS PANIC WITH SALIVA TESTS FOR RADIATION EXPOSURE

GENETIC ANALYSIS OF AIRFLOW OBSTRUCTION AFTER STEM CELL TRANSPLANTATION

MECHANISMS OF ORGANELLE DETERIORATION

STATINS FOR PREVENTION OF GVHD

ALPHA-CATENIN IN REGULATION OF TISSUE HOMEOSTASIS AND CANCER

REGULATORY T CELL MODULATION OF IMMUNITY TO MUCOSAL VIRAL INFECTIONS

CYTOTOXIC T-CELL RESPONSES TO HSV IN HIV-INFECTED PERSONS

T CELL MODULATION BY NKG2D

ELUCIDATION OF A BACTERIAL CELL SHAPE GENERATING PROGRAM AND PATHOGENIC FUNCTIONS

TILLING THE ZEBRAFISH GENOME: A REVERSE GENETIC APPROACH

ADOPTIVE T CELL THERAPY OF MELANOMA TARGETING NY-ESO-1

MECHANISMS OF TANGENTIAL NEURON MIGRATION

DYNAMICS OF GRADIENT SENSING IN SINGLE CELLS

"NEUTROPHIL ELASTASE LINKS IDIOPATHIC PULMONARY FIBROSIS AND LUNG CANCER"

DISSECTING THE MECHANISM OF INCREASED GENOMIC INSTABILITY IN AGING YEAST

POPULATION PHARMACOKINETICS/PHARMACODYNAMICS IN NONABLATIVE STEM CELL RECIPIENTS

NOVEL CULTIVATION METHODS FOR THE DOMESTICATION OF VAGINAL BACTERIA

FFPE VALIDATION OF A SURVIVAL GENE SIGNATURE IN HPV-NEGATIVE ORAL CAVITY CANCER

NORMAL AND CANCER STEM CELLS OF THE MAMMARY GLAND

INTERROGATION OF MLL2 AS A TUMOR SUPPRESSOR GENE IN LUNG CANCER

HIGH-PERFORMANCE COMPUTE CLUSTER FOR COMPREHENSIVE CANCER AND INFECTIOUS DISEASES RESEARCH

IRS-1 REGULATES INFLAMMATORY CELL RECRUITMENT IN LUNG CANCER

CHEMOPROTECTION AGAINST AMINOGLYCOSIDE-INDUCED OTOTOXICITY

PREVENTING TUMOR RELAPSE WITH BIOMATERIAL-SUPPORTED LYMPHOCYTE IMPLANTS

CELL-STRESS INDUCED IMMUNE RESPONSES

USING GENETICALLY ENGINEERED MOUSE MODELS OF BRAIN TUMORS TO DEVELOP THERAPEUTIC NANOPARTICLES & BIOMATERIALS