National University

FLORIDA INTERNATIONAL UNIVERSITY CARES ACT: HIGHER EDUCATION EMERGENCY RELIEF FUND APPLICATION - INSTITUTIONAL PORTION

FLORIDA INTERNATIONAL UNIVERSITY CARES ACT: HIGHER EDUCATION EMERGENCY RELIEF FUND APPLICATION

FIU'S ENVIRONMENTAL RESEARCH, DEVELOPMENT, & TECHNOLOGY TESTING & EVALUATION FOR DOE

GAINING EARLY AWARENESS AND READINESS FOR UNDERGRADUATE PROGRAMS (GEAR UP PARTNERSHIP)

FIU CENTER FOR REDUCING HEALTH DISPARITIES IN SUBSTANCE ABUSE & HIV IN SOUTH FLORIDA

TEXAS A&M INTERNATIONAL UNIVERSITY (TAMIU) CARES ACT INSTITUTION 2020

TEXAS A&M INTERNATIONAL UNIVERSITY (TAMIU) CARE ACT FOR STUDENTS 2020

THE APPLIED RESEARCH CENTER (ARC) AT FLORIDA INTERNATIONAL UNIVERSITY (FIU) SHALL PROVIDE TECHNICAL SUPPORT TO DOE EM IN THE AREA OF ENVIRONMENTAL REMEDIATION AND WORKFORCE DEVELOPMENT. FIU-ARC’S RESEARCH AND TECHNOLOGY DEVELOPMENT, DEMONSTRATION AND TESTING OVER THE NEXT 5 YEARS WILL BE IN THE 4 MAJOR AREAS OF ENVIRONMENTAL CLEANUP OPERATIONS: RADIOACTIVE WASTE PROCESSING, SOIL & GROUNDWATER REMEDIATION, FACILITY DECONTAMINATION AND DECOMMISSIONING AND TAILORED INFORMATION TECHNOLOGY DEVELOPMENT FOR ENVIRONMENTAL MANAGEMENT. PROJECT 1: CHEMICAL PROCESS ALTERNATIVES FOR RADIOACTIVE WASTE. PROJECT 1'S SPECIFIC TASKS INCLUDE: ADVANCED TOPICS FOR HLW MIXING AND PROCESSING; TECHNOLOGY DEVELOPMENT AND INSTRUMENTATION EVALUATION; PIPELINE INTEGRITY AND ANALYSIS; AND CORROSION PROTECTION AND CHARACTERIZATION OF EM INFRASTRUCTURE. PROJECT 2: ENVIRONMENTAL REMEDIATION SCIENCE & TECHNOLOGY. PROJECT 2'S SPECIFIC TASKS INCLUDE: REMEDIATION RESEARCH AND TECHNICAL SUPPORT FOR THE HANFORD SITE; REMEDIATION RESEARCH AND TECHNICAL SUPPORT FOR SAVANNAH RIVER SITE; CONTAMINANT FATE AND TRANSPORT MODELING FOR THE SAVANNAH RIVER SITE; REMEDIATION RESEARCH AND TECHNICAL SUPPORT FOR WIP; HYDROLOGY MODELING FOR THE WASTE ISOLATION PILOT PLANT (WIPP); AND ENGINEERED MULTI-LAYER AMENDMENT TECHNOLOGY FOR HG REMEDIATION ON OAK RIDGE RESERVATION. PROJECT 3: WASTE AND D&D ENGINEERING AND TECHNOLOGY DEVELOPMENT PROJECT 3'S SPECIFIC TASKS INCLUDE: WASTE INFORMATION MANAGEMENT SYSTEM (WIMS); D&D SUPPORT TO DOE EM FOR TECHNOLOGY INNOVATION, DEVELOPMENT, EVALUATION, AND DEPLOYMENT; KNOWLEDGE MANAGEMENT INFORMATION TOOL; AI & BIG DATA ANALYTICS: STRUCTURAL HEALTH MONITORING FOR D&D; AND AI FOR EM PROBLEM SET – SOIL AND GROUNDWATER. PROJECT 4: DOE-FIU SCIENCE AND TECHNOLOGY WORKFORCE DEVELOPMENT PROGRAM. PROJECT 5: DOE-FIU SCIENCE AND TECHNOLOGY WORKFORCE DEVELOPMENT PROGRAM FOR THE OFFICE OF LEGACY MANAGEMENT.

FIU-ABCD: PATHWAYS AND MECHANISMS TO ADDICTION IN THE LATINO YOUTH OF SOUTH FLORIDA

WEST AFRICA WATER, SANITATION AND HYGIENE PROGRAM

NU CARES ACT HEERF ALLOCATION INSTITUTIONAL PORTION

THIS IS A THREE YEARS COOPERATIVE AGREEMENT WITH A CEILING OF $12,593,895 AND INITAL OBLIGATION OF $4,200,000

NEW CA AWARD FIU

RENEWAL FOR HEMISPHERIC CENTER FOR ENVIRONMENTAL TECHNOLOGY PROJECT

FLORIDA INTERNATIONAL UNIVERSITY-HEALTH DISPARITIES INITIATIVE (FIU-HDI)

FLORIDA INTERNATIONAL UNIVERSITY CARES ACT: HIGHER EDUCATION EMERGENCY RELIEF FUND APPLICATION -MINORITY SERVING INSTITUTIONS

CENTERS FOR ADVANCED STUDIES IN ENERGY CAS-EN

NU CARES ACT ALLOCATION HEERF

METABOLIC REPROGRAMMING AND PULMONARY VASCULAR DISEASE IN CONGENITAL HEART DISEASE

MID-SCALE RI-1 (M1:DP): NATIONAL FULL-SCALE TESTING INFRASTRUCTURE FOR COMMUNITY HARDENING IN EXTREME WIND, SURGE, AND WAVE EVENTS (NICHE)

CENTER FOR SUBSTANCE USE AND AIDS RESEARCH ON LATINOS IN THE UNITED STATES

GENETICS, EPIGENETICS, AND POST-TRANSLATIONAL MODIFICATIONS AND THE DEVELOPMENT OF VENTILATOR-INDUCED LUNG INJURY (VILI)

ENGAGING A NETWORK OF LOCALLY ACCESSIBLE COMMUNITY ESTABLISHMENTS AND SCHOOLS (ENLACES)

AS PART OF THE FLORIDA RISK AND RESILIENCE TECH HUB, THIS EDA INVESTMENT WILL HELP ACCELERATE NEW CEMENT/CONCRETE TECHNOLOGIES TO MARKET AND DEVELOP TRAINING AND EDUCATION PROGRAMS FOR NOVEL MATERIALS. THE PROJECT WILL LEVERAGE THE RESOURCES OF COMPONENT PROJECT PARTNERS TO PROVIDE CRITICAL SUPPORT TO HELP FLEDGING INFRASTRUCTURE COMPANIES GROW AND REMOVE BARRIERS TO ADOPTION OF NEW MATERIALS AND TECHNOLOGIES DEVELOPED IN THE COMPONENT PROJECT BY MODERNIZING POLICIES, STANDARDS, AND SPECIFICATIONS TO STREAMLINE APPROVALS AND SCALE ADOPTION. ACTIVITIES TO BE PERFORMED: VALIDATE AND DEPLOY TERNARY CEMENT, CAPTURECRETE, PORTABLE ULTRA-HIGH PERFORMANCE CONCRETE DEPLOYMENT SYSTEM, AND OTHER NEW CEMENT/CONCRETE TECHNOLOGIES. DEVELOP AND CONDUCT TRAINING CURRICULUM AND ECOSYSTEM EDUCATION WORKSHOPS. SUPPORT STARTUPS IN TECHNOLOGY TESTING AND VALIDATION, NEW BUSINESS DEVELOPMENT, INDUSTRY MENTORSHIP, AND INDUSTRY-SPECIFIC TECHNICAL ASSISTANCE. GROW AND RECRUIT LOCAL STARTUPS / SMALL BUSINESSES TO PARTICIPATE IN INNOVATION SYSTEM. DEVELOP GOVERNANCE, POLICIES, AND PROCEDURES TO SUPPORT LOCAL STARTUPS AND MARKETING MATERIALS TO RECRUIT STARTUPS. DEVELOP MODEL BUILDING CODES AND SPECIFICATIONS TO BE IMPLEMENTED LOCALLY (I.E., THE "FLORIDA STANDARD") AND REPLICATED NATIONALLY TO ACCELERATE ADOPTION OF NOVEL MATERIALS AND TECHNOLOGIES DEVELOPED AND VALIDATED THROUGH THE TECH HUB.

NEW START COOPERATIVE AGREEMENT: DOD COE: CENTER FOR INTEGRATED RENEWABLE ENERGY AND ENERGY STORAGE (CIREES)

THE NATION'S COASTLINES ARE FACING UNPRECEDENTED CHANGE DUE TO SEA LEVEL RISE. WHILE THIS MAY BE HIGHLY VISIBLE IN MANY CASES AS THE SEA SWALLOWS LAND, ROADS, BUILDINGS, AND OTHER INFRASTRUCTURE, MAJOR, POTENTIALLY DISRUPTIVE CHANGES WILL ALSO BE HAPPENING IN THE UNSEEN SUBSURFACE. THE THREAT IS MOST SIGNIFICANT IN HIGHLY DEVELOPED URBAN AREAS. AS THE SEA RISES, COASTAL WATER TABLES RISE TOO, FLOODING FOUNDATIONS, BURIED UTILITIES, AND OTHER SUBSURFACE INFRASTRUCTURE, AND INCREASING SURFACE FLOODING BY REDUCING THE AMOUNT OF INFILTRATED RAINFALL THAT CAN BE STORED. RISING SEAS WILL INCREASE SALTWATER INTRUSION INTO COASTAL AREAS, WITH POTENTIALLY DEVASTATING CORROSION IMPACTS ON FOUNDATIONS AND OTHER BURIED INFRASTRUCTURE. THE FUNDING IS ANTICIPATED TO BE SPENT DETERMINING THE OPTIMAL SITES FOR MONITORING SYSTEM INSTALLATION, CLEARING THE SITES FOR BURIED UTILITY CONFLICTS, OBTAINING NECESSARY PERMITS, PURCHASING MONITORING EQUIPMENT, INSTALLING THE SYSTEMS, PROVIDING FOR CLOUD-BASED M

COHORT STUDIES ON HIV/AIDS AND SUBSTANCE ABUSE IN MIAMI

PURPOSE/SCOPE: THE PURPOSE OF THIS PROJECT IS TO DESIGN, BUILD AND OPERATE A NEW ROBOTICS AND AUTONOMOUS SYSTEMS LABORATORY FOR COASTAL CONSERVATION AND RESTORATION (RASCAR) TO ENHANCE OUR TECHNOLOGICAL ABILITIES AND APPROACHES TO COASTAL ECOSYSTEM MONITORING, RESTORATION AND CONSERVATION. THIS PROJECT CONSISTS OF FOUR SUB-PROJECTS INCLUDING THREE EXISTING STRUCTURES THAT WILL BE RENOVATED OR IMPROVED AND A NEW BUILDING. THE COASTAL CONSERVATION AND RESEARCH LABORATORY IS 28,827 TOTAL SQUARE FEET AND IS COMPRISED OF TWO LABORATORY BUILDINGS (3,872, AND 1,366 SQUARE FEET), AN OUTDOOR RESEARCH TANK FACILITY (6,203 SQUARE FEET) AND THE NEWLY CREATED MOTION CAPTURE TANK FACILITY (1,180 SQUARE FEET). THE SECOND EXISTING FACILITY IS COMPRISED OF TWO FORMER CLASSROOMS (1,100 SQUARE FEET COMBINED) THAT WILL BE MODIFIED TO BE A COMPUTING CENTER AS WELL AS AN EDUCATION AND OUTREACH FACILITY. THE THIRD PLANNED RENOVATION WILL OCCUR IN THE NEWLY CONSTRUCTED ENGINEERING BUILDING LOCATED ON THE MODESTO MAIDIQUE CAMPUS IN MIAMI, FLORIDA. TO INCLUDE RENOVATING 2,000 SQUARE FEET TO CREATE THE ENVIRONMENTAL SENSING, COMPUTING AND ENGINEERING INNOVATION FACILITY. THE NEW BUILDING WILL CONSIST OF A 6,000 SQUARE FOOT MULTI-USE, MULTI-PURPOSE BUILDING THAT WILL INCLUDE OFFICES AND LABORATORIES FOR FACULTY AND STUDENTS ASSOCIATED WITH THIS INITIATIVE, MANUFACTURING SPACE TO CONSTRUCT LARGE-SCALE AUTONOMOUS VEHICLES AND A SPACE FOR TESTING CAPABILITIES SUCH AS A HYDROSTATIC TANK TO DETERMINE PRESSURE TOLERANCES OF MANUFACTURED SUBMERSIBLE AUTONOMOUS VEHICLES AND ROBOTS. NON-BUILDING EQUIPMENT INCLUDES COMPUTER STATIONS; 3D PRINTERS AND CUTTERS; MULTI-BEAM SONAR SYSTEMS, ACOUSTIC COMMUNICATIONS, UNDER WATER LIGHTING AND HYDROPHONES.ACTIVITIES TO BE PERFORMED: THIS WILL BE ACHIEVED THROUGH FOUR MAJOR ACTIVITIES. FIRST, WE WILL CONSTRUCT A NEW RESEARCH AND DEVELOPMENT COMPLEX. SECOND, WE WILL MODIFY AN EXISTING SPACE TO HOUSE THE COMPUTING AND DATA VISUALIZATION EQUIPMENT NECESSARY TO STORE, ANALYZE AND COMMUNICATE THE DATA OBTAINED FROM THE NEWLY DEVELOPED ROBOTS AND AUTONOMOUS VEHICLES. THIRD, WE WILL ENHANCE OUR MOTION CAPTURE FACILITY BY PROVIDING HIGH QUALITY SALT WATER NECESSARY TO TEST THE EFFICACY OF THE AUTONOMOUS VEHICLES. IN ADDITION, WE WILL PROVIDE WIRELESS INTERNET TO THIS FACILITY TO PROVIDE THE ABILITY TO DIRECTLY COMMUNICATE TO DEPLOYED ROBOTS AND AUTONOMOUS VEHICLES. FINALLY, WE WILL ESTABLISH AN ENVIRONMENT SENSING, COMPUTING AND ENGINEERING LABORATORY IN THE NEWLY CONSTRUCTED ENGINEERING BUILDING.EXPECTED OUTCOMES: ACTIVITIES AT THIS FACILITY INCLUDE THE DEVELOPMENT OF NEW ENVIRONMENTAL SENSORS, ENVIRONMENTAL ROBOTS AND AUTONOMOUS VEHICLES THAT WILL ENHANCE OUR ABILITY TO MONITOR AND MEASURE KEY COASTAL ECOSYSTEM PARAMETERS. INTENDED BENEFICIARIES:THE INTENDED BENEFICIARIES INCLUDE THE SCIENTIFIC MANAGEMENT; LOCAL; OUR NATIONAL, STATE, REGIONAL AND LOCAL COLLABORATORS SUCH AS NOAA, NPS, USGS, FLORIDA DEPARTMENT OF ENVIRONMENTAL PROTECTION, DEPARTMENT OF ENVIRONMENTAL RESOURCES MANAGEMENT; LOCAL MUNICIPALITIES AND THE BUSINESS SECTOR THAT DEPEND ON OUR COASTAL RESOURCES AND HEALTH; K-GRADUATE STUDENTS, THAT WILL BE PROVIDED WITH NEXT-GENERATION EDUCATION AND TRAINING OPPORTUNITIES.SUBRECIPIENT ACTIVITIES: NONEUSEFUL LIFE: 15 YEARS FOR RENOVATION COMPONENTS / 20 YEARS FOR NEW CONSTRUCTION COMPONENTS

RWANDA INTEGRATED WATER SECURITY PROGRAM (RIWSP)

AMLIGHT: THE NEXT FRONTIER TOWARDS DISCOVERY IN THE AMERICAS AND AFRICA -THE AMLIGHT: THE NEXT FRONTIER TOWARDS DISCOVERY IN THE AMERICAS AND AFRICA PROJECT CONTINUES ITS MISSION TO MAINTAIN A PURPOSE-BUILT INTERNATIONAL NETWORK INFRASTRUCTURE TO SUPPORT THE VERA RUBIN OBSERVATORY AND U.S. ASTRONOMY PROJECTS, MAJOR FACILITIES, SCIENTIFIC WORKFLOWS, NETWORK TESTBEDS, AND THE R&E COMMUNITIES IN THE U.S., LATIN AMERICA, AND AFRICA BY MAINTAINING CRITICAL LONG-HAUL CONNECTIVITY, COLOCATION, AND SOFTWARE SERVICES THAT DIRECTLY SUPPORT U.S.-LED GLOBAL SCIENCE INITIATIVES. THE PROJECT ENHANCES THE NETWORK OPERATION AND AUTOMATION TO GUARANTEE NEW LEVELS OF OBSERVABILITY, PROGRAMMABILITY, INTEGRATION WITH SCIENCE WORKFLOWS AND TESTBEDS, AND DATA TRANSFER PERFORMANCE. RESEARCH CONTRIBUTIONS INCLUDE NEW MODELS FOR PREDICTIVE FAULT DETECTION, TELEMETRY-DRIVEN AUTOMATION, SMART NETWORK INTERFACE-BASED MONITORING, AND MULTI-DOMAIN ORCHESTRATION. THESE INNOVATIONS SERVE AS LIVE, REPRODUCIBLE PLATFORMS FOR COMPUTER NETWORKING, CYBERSECURITY, MACHINE LEARNING, AND DISTRIBUTED SYSTEMS RESEARCH. THE PROJECT ENABLES TRANSFORMATIONAL SCIENCE AND EDUCATION BY SUPPORTING LONG-TERM DATA-INTENSIVE WORKFLOWS ACROSS LATIN AMERICA AND AFRICA, DIRECTLY BENEFITING U.S. ACCESS TO GLOBALLY DISTRIBUTED FACILITIES, SUCH AS THE VERA RUBIN OBSERVATORY, U.S. ASTRONOMY PROJECTS, THE LARGE HADRON COLLIDER, AND ENVIRONMENTAL SENSING. THE PROJECT CONTRIBUTES OPEN-SOURCE TOOLS; FINDABLE, ACCESSIBLE, INTEROPERABLE, AND REUSABLE DATASETS FOR MACHINE LEARNING AND CYBERSECURITY RESEARCH; AND OPERATIONAL TELEMETRY USED BY NATIONAL LABORATORIES AND ACADEMIC RESEARCHERS. BY SHARING LARGE-SCALE TELEMETRY DATA, AUTOMATION FRAMEWORKS, AND EXPERIMENTAL PLATFORMS, THE PROJECT ENABLES BROADER ENGAGEMENT IN REPRODUCIBLE RESEARCH AND INFRASTRUCTURE SCIENCE. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

DEVELOPMENT OF INTERMODAL PERCEPTION OF SOCIAL EVENTS: INFANCY TO CHILDHOOD

UNIVERSITY TRANSPORTATION CENTERS

MBRS RESEARCH INITIATIVE FOR SCIENTIFIC ENHANCEMENT

IRNC-PRONET: AMERICAS LIGHTPATHS: INCREASING THE RATE OF DISCOVERY AND ENHANCING EDUCATION ACROSS THE AMERICAS

COHORT STUDIES OF HIV/AIDS AND SUBSTANCE USE IN MIAMI - THIS IS A PROPOSAL FOR THE CONTINUATION OF THE WELL-CHARACTERIZED MIAMI ADULT STUDIES ON HIV (MASH) COHORT OF MIDDLE-TO-OLD, AGED PEOPLE LIVING WITH AND WITHOUT HIV AND SUBSTANCE USE FOLLOWED BIANNUALLY, WITH A HISTORY OF MULTIDISCIPLINARY COLLABORATION. AFTER 3% YEARLY DROPOUT, MASH (N=1,439) HAS PEOPLE LIVING WITH HIV & COCAINE USE (N=231), HIV & NO COCAINE USE (N=445), NO HIV WITH COCAINE USE (N=324), AND NO HIV WITH NO COCAINE USE (N=439), FOLLOWED BIANNUALLY. THE MASH INFRASTRUCTURE HAS ACCRUED >8,000 VISITS, >500,000 BIOSPECIMENS, >900 MRI SCANS, MICROBIOME AND EPIGENETIC DATA, AND A DATABASE OF >6,000 VARIABLES ON HIV, SUBSTANCE USE, STRUCTURAL FACTORS, AND COMORBIDITIES. AS THE ONLY NIDA HIV COHORT IN THE SOUTH, OUR WORK ADDRESSES NIH-HIV RESEARCH PRIORITIES ON THE INTERSECTION OF HIV AND SUBSTANCE USE, SPECIFICALLY COCAINE, WHICH IS WIDELY USED BY PEOPLE LIVING WITH HIV (PLWH), AND COMORBIDITIES INCLUDING NEUROCOGNITIVE IMPAIRMENT (NCI) AND PHYSICAL FRAILTY, A PHENOTYPE OF PHYSIOLOGICAL DETERIORATION LINKED TO DISABILITY AND MORTALITY. WE PROPOSE TO EXPAND THE MASH COHORT TO 1,879 PEOPLE TO INCREASE REPRESENTATION OF WOMEN WHILE FOLLOWING THE PARTICIPANTS FOR HIV, SUBSTANCE USE PATTERNS, EMERGENT COMORBIDITIES, AND POLY-SOCIAL RISK. WITH THE NEW RECRUITMENT, MASH WILL BECOME A COHORT OF PREDOMINANTLY WOMEN, REPRESENTING A POPULATION LACKING AMONG NIDA COHORTS, YET REMAINS IMPACTED BY HIV AND SUBSTANCE ABUSE. THE SCIENTIFIC AIMS OF THIS PROPOSAL INVOLVE EPIGENETIC, NEUROIMAGING, AND NEUROCOGNITIVE PATTERNS OF COGNITIVE FRAILTY, AND ARE TO (1) LONGITUDINALLY INVESTIGATE DIFFERENTIAL EPIGENETIC PATTERNS IN PEOPLE LIVING WITH AND WITHOUT HIV AND COCAINE USE THAT PREDICT COGNITIVE FRAILTY. EPIGENETIC MODIFICATIONS, AN INTERFACE BETWEEN THE GENOME AND ENVIRONMENT, ARE ASSOCIATED WITH HIV, DRUG ABUSE, PHYSICAL FRAILTY, NCI, AND SOCIAL FACTORS, AND CAN PREDICT HEALTH OUTCOMES, YET REMAIN UNDERSTUDIED IN THE CONTEXT OF HIV AND SUBSTANCE USE. SCIENTIFIC AIM (2) IS TO INVESTIGATE WHETHER THE EPIGENETIC SIGNATURES PREDICT STRUCTURAL AND FUNCTIONAL NEUROIMAGING PATTERNS, WHICH THEN CAN PREDICT NEUROCOGNITIVE AND PHYSICAL COMPONENTS OF COGNITIVE FRAILTY OVER TIME, CONSIDERING SEX AND SOCIAL RISK. THIS WORK INTEGRATES THE HEALTH PROMOTION RESEARCH CENTER FRAMEWORK TO LEVERAGE EXISTING RELATIONSHIPS WITH END-USERS TO BRIDGE RESEARCH AND PRACTICE. OUR GOAL IS TO IMPLEMENT RESEARCH INTO ACTIONABLE STRATEGIES SUCH AS COLOCATION OF HIV CARE AND SUBSTANCE ABUSE TREATMENT, IDENTIFICATION OF EARLY COGNITIVE FRAILTY DIAGNOSTIC MARKERS, AND PREDICTION OF CLINICAL TRAJECTORIES. BY EMPLOYING MULTIMODAL NEUROIMAGING COMBINED WITH EPIGENETICS, NEUROCOGNITIVE, AND PHYSICAL FRAILTY ASSESSMENTS, THIS PROJECT AIMS TO ENABLE PRECISION MEDICINE APPROACHES IN THE CONTEXT OF COGNITIVE FRAILTY BY IDENTIFYING SPECIFIC PATHOLOGIES IN PLWH WITH COCAINE USE. BY LEVERAGING THE UNIQUE CHARACTERISTICS OF MASH, THIS STUDY HAS THE POTENTIAL TO GENERATE VALUABLE INSIGHTS INTO THE INTERPLAY OF HIV, COCAINE USE, AND COGNITIVE FRAILTY, WHILE THE INTEGRATION OF IMPLEMENTATION SCIENCE WILL INFORM EFFECTIVE SOLUTIONS.

UNIDOS HSI PROGRAM NETWORK RESOURCE CENTER FOR COMMUNITY COORDINATION -WITH SUPPORT FROM THE IMPROVING UNDERGRADUATE STEM EDUCATION: HISPANIC-SERVING INSTITUTIONS (HSI PROGRAM), THIS CENTER PROJECT AIMS TO COORDINATE AND AMPLIFY THE WORK OF HISPANIC SERVING INSTITUTIONS (HSIS). HISPANIC SERVING INSTITUTIONS PLAY A UNIQUE ROLE IN PROMOTING THE PARTICIPATION AND SUCCESS OF HISTORICALLY UNDERSERVED GROUPS OF STUDENTS IN STEM EDUCATION. HOWEVER, THE SUCCESSES OF INDIVIDUAL FACULTY, STAFF AND INSTITUTIONS CAN BE FURTHER EXTENDED THROUGH INCREASED INFRASTRUCTURE, NEW PARTNERSHIPS AND AMPLIFICATION OF HSI SUCCESSES AND HSI EXPERTISE. THE UNIDOS CENTER AIMS TO FURTHER STRENGTHEN THE IMPACT OF HSIS BY PROVIDING MEMBERS OF THE HSI COMMUNITY OPPORTUNITIES TO LEARN FROM AND BUILD ON EACH OTHER?S WORK AND FORM NEW PARTNERSHIPS THAT LEAD TO INNOVATIONS IN HSI EDUCATION. ADDITIONALLY, THE UNIDOS CENTER WILL IMPACT CURRENT HSI FACULTY, STAFF AND STUDENTS BY PROVIDING PROFESSIONAL LEARNING ACTIVITIES FOCUSED ON PROPOSAL DEVELOPMENT, TEACHING, AND LEADERSHIP DESIGNED TO FOSTER INCREASED STUDENT SUCCESS THROUGH IMPROVED RESEARCH, TEACHING, AND PROGRAMMATIC ACTIVITIES. UNIDOS IS A CENTER FOR HSIS BY HSIS, WITH A LEADERSHIP TEAM AND ENGAGED PARTNERS THAT REPRESENT THE DIVERSITY OF HISPANIC-SERVING INSTITUTIONS AND THE MANY GROUPS THEY SERVE. THE CENTER WILL BE LED BY EXPERTS FROM FIVE INSTITUTIONS WITH ESTABLISHED RECORDS IN HISPANIC/LATIN? STEM STUDENT SUCCESS: FLORIDA INTERNATIONAL UNIVERSITY; VALENCIA COLLEGE; CALIFORNIA STATE UNIVERSITY, SACRAMENTO; THE UNIVERSITY OF PUERTO RICO - RIO PIEDRAS; AND THE UNIVERSITY OF TEXAS AT EL PASO. THE CENTER?S LARGER LEADERSHIP TEAM ALSO INCLUDES PROFESSIONAL ORGANIZATIONS: THE HISPANIC ASSOCIATION OF COLLEGES AND UNIVERSITIES (HACU), THE SOCIETY FOR THE ADVANCEMENT OF CHICANOS/HISPANICS AND NATIVE AMERICANS IN SCIENCE (SACNAS) AND EXCELENCIA IN EDUCATION. THE GOALS OF THE UNIDOS CENTER INCLUDE: 1) BUILDING CONNECTIONS BY DEVELOPING STRONGER SYNERGIES BETWEEN HSI COMMUNITY MEMBERS THROUGH ORGANIZING THE HSI PROGRAM AWARDEE MEETING, FOMENTING PARTNERSHIPS THROUGH TECHNOLOGY AND INTENTIONAL NETWORKING, AND DEPLOYING COLLABORATIVE INNOVATION SANDBOX MEETINGS FOR PARTICIPANTS TO DISCUSS BOLD IDEAS; 2) BUILDING CAPACITY BY DEVELOPING THE COMMUNITY?S PROPOSAL DEVELOPMENT, LEADERSHIP, AND TEACHING CAPACITY THROUGH PROPOSAL WORKSHOPS AND RESOURCES, A MENTORING PROGRAM, AND FACULTY DEVELOPMENT ON TEACHING; 3) ELEVATING HSI VOICES BY HOSTING LISTENING SESSIONS WITH HSI COMMUNITY MEMBERS, CONVENE HSI COUNCILS OF EXPERTS TO PLATFORM HSIS? EXPERTISE, AND FORM WORKING GROUPS TO DESIGN TOOLKITS AND RESOURCES ON CRITICAL TOPICS OF HSIS; AND 4) FACILITATING COMMUNICATION BY AMPLIFYING THE WORK OF HSIS THROUGH A COMPREHENSIVE COMMUNICATION PLAN, INCLUDING DEPLOYMENT OF WEBSITE, SOCIAL MEDIA, NEWSLETTERS, AND A SEMINAR SERIES. ADDITIONALLY, THE SOCIAL NETWORK ANALYSES AND OTHER EXTERNAL EVALUATION WILL YIELD NEW KNOWLEDGE ON HOW HSI COMMUNITY MEMBERS CONNECT AND COLLABORATE WITH EACH OTHER. THIS PROJECT IS FUNDED BY THE HSI PROGRAM, WHICH AIMS TO ENHANCE UNDERGRADUATE STEM EDUCATION, BROADEN PARTICIPATION IN STEM, AND BUILD CAPACITY AT HSIS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

SLEEP-DEPENDENT NEGATIVE OVERGENERALIZATION IN PERI-PUBERTAL ANXIETY

NMDA RECEPTOR FUNCTION IN LEAD NEUROTOXICITY

IRNC: BACKBONE: AMLIGHT EXPRESS AND PROTECT (EXP)

TOXICANT-INDUCED NEUROTOXICITY MEDIATED BY GLIA-NEURON AND GENE-ENVIRONMENT INTERACTIONS IN PARKINSON'S DISEASE

IRNC: CORE IMPROVEMENT: ATLANTICWAVE-SDX: A DISTRIBUTED EXPERIMENTAL SDX SUPPORTING RESEARCH, EXPERIMENTAL DEPLOYMENTS, AND INTEROPERABILITY TESTING ON GLOBAL SCALES

CRRSAA EMERGENCY FINANCIAL AID GRANTS TO STUDENTS - FLORIDA NATIONAL UNIVERSITY OPEID 02547600

INTEGRATED NATURAL RESOURCE MANAGEMENT IN WATERSHED PROGRAM

LTER: FCE III - COASTAL OLIGOTROPHIC ECOSYSTEMS RESEARCH

NATURAL HAZARDS ENGINEERING RESEARCH INFRASTRUCTURE: EXPERIMENTAL FACILITY WITH TWELVE-FAN WALL OF WIND 2021-2025

PERINATAL REGULATION OF ENDOTHELIAL NOS

MARA RIVER BASIN WATER AND BIODIVERSITY PROGRAM

UNIVERSITY TRANSPORTATION CENTERS

CREST PHASE II: CENTER FOR AQUATIC CHEMISTRY AND ENVIRONMENT (CACHE)

CREST: CENTER FOR INNOVATIVE INFORMATION SYSTEMS ENGINEERING

PERIPHERAL BDZ RECEPTOR: A BIOMARKER OF NEUROTOXICITY

CONFIRMING P1 AS A STABLE BIOMARKER OF ATTENTION TO SOCIAL THREAT IN PERI-PUBERTAL YOUTH

HADRONIC PHYSICS WITH ELECTROMAGNETIC PROBES

CREST: CENTER FOR AQUATIC CHEMISTRY AND THE ENVIRONMENT

TREATMENT RESEARCH INVESTIGATING DEPRESSION EFFECTS ON NEUROIMMUNE TARGETS (TRIDENT) - PROJECT SUMMARY SINCE THE EARLY DAYS OF THE EPIDEMIC, PSYCHONEUROIMMUNOLOGY RESEARCH ESTABLISHED THAT THERE IS A BI- DIRECTIONAL RELATIONSHIP BETWEEN DEPRESSION AND HIV PATHOGENESIS. AMONG PEOPLE WITH HIV (PWH), SUBSTANTIAL DAMAGE TO THE GASTROINTESTINAL TRACT OCCURS DURING ACUTE HIV INFECTION, WHICH IS PARTIALLY RESPONSIBLE FOR DYSREGULATION OF THE GUT MICROBIOME (I.E., DYSBIOSIS) AND TRANSLOCATION OF INFLAMMATORY MICROBIAL PRODUCTS INTO THE PERIPHERY. EVEN AMONG THOSE RECEIVING EFFECTIVE ANTI-RETROVIRAL THERAPY (ART), THESE PATHOPHYSIOLOGIC ALTERATIONS IN THE GUT DRIVE PERSISTENT IMMUNE DYSREGULATION THAT PARTIALLY EXPLAINS AMPLIFIED RISK FOR DEPRESSION AND OTHER NEUROPSYCHIATRIC DISORDERS IN PWH. AN IMPORTANT GAP IS THAT NO PRIOR CLINICAL RESEARCH IN PWH RECEIVING EFFECTIVE ART HAS EXAMINED THE FUNCTIONAL CONNECTIONS BETWEEN THE MICROBIOME, GASTROINTESTINAL TRACT, IMMUNE SYSTEM, AND THE BRAIN – THE MICROBIOME-GUT-BRAIN (MGB) AXIS. TREATMENT RESEARCH INVESTIGATING DEPRESSION EFFECTS ON NEUROIMMUNE TARGETS (TRIDENT) IS A RANDOMIZED CONTROLLED TRIAL THAT LEVERAGES AN EVIDENCE-BASED COGNITIVE-BEHAVIORAL THERAPY FOR ADHERENCE AND DEPRESSION (CBT-AD) TREATMENT AS AN EXPERIMENTAL PROBE TO ADVANCE OUR UNDERSTANDING OF HOW DECREASING DEPRESSION ALTERS MGB AXIS PATHWAYS IN PWH. TRIDENT WILL ENROLL 120 DEPRESSED PWH TAKING AN INTEGRASE STRAND TRANSFER INHIBITOR (INSTI)-BASED ART REGIMEN WHO HAVE AN UNDETECTABLE VIRAL LOAD. TRIDENT WILL HAVE A BRIEF RUN-IN PERIOD (I.E., WAITING PERIOD PRIOR TO RANDOMIZATION) WHERE POTENTIALLY ELIGIBLE PARTICIPANTS WILL BE ASKED TO COMPLETE A BASELINE PSYCHOSOCIAL ASSESSMENT, PROVIDE BIOSPECIMENS, AND ATTEND A SEPARATE BASELINE FMRI ASSESSMENT. A TOTAL OF 120 PARTICIPANTS WHO COMPLETE THE RUN-IN PERIOD WILL BE RANDOMIZED TO RECEIVE EITHER: 1) CBT-AD (N = 60); OR 2) A WAIT-LIST CONTROL (WLC) CONDITION (N = 60). IMMEDIATELY FOLLOWING RANDOMIZATION, CBT-AD PARTICIPANTS WILL RECEIVE UP TO 12 INDIVIDUAL SESSIONS OVER 4 MONTHS. WLC PARTICIPANTS WILL HAVE THE OPPORTUNITY TO RECEIVE THE CBT-AD TREATMENT AFTER A 6-MONTH DELAY. DURING THE INTENT-TO-TREAT PERIOD, FOLLOW-UP ASSESSMENTS AT 2 MONTHS AND 4 MONTHS (I.E., DURING AND IMMEDIATELY FOLLOWING THE DELIVERY OF CBT-AD) WILL CHARACTERIZE CHANGES IN THE MICROBIOME, SOLUBLE IMMUNE MARKERS RELEVANT TO HIV PATHOGENESIS, AND LEUKOCYTE SIGNALING TO MEASURE THE CONSERVED TRANSCRIPTIONAL RESPONSE TO ADVERSITY (CTRA). THESE WILL BE EXAMINED AS PLAUSIBLE MEDIATORS OF CBT-AD RELATED IMPROVEMENTS IN THE PRIMARY OUTCOME – RESTING STATE ACTIVATION AND CONNECTIVITY OF THE NEGATIVE VALENCE SYSTEM AT 6 MONTHS (ASSESSED VIA FMRI). SIX MONTHS AFTER RANDOMIZATION, WLC PARTICIPANTS WILL CROSSOVER AND HAVE THE OPPORTUNITY TO RECEIVE CBT-AD, AND ALL PARTICIPANTS (BOTH CBT-AD AND WLC) WILL COMPLETE A FINAL FOLLOW-UP ASSESSMENT AT 10 MONTHS. TRIDENT WILL HAVE AN EXCEPTIONAL IMPACT BY PROVIDING AN EXPERIMENTAL MODEL TO ADVANCE OUR UNDERSTANDING OF HOW DECREASING DEPRESSION CHANGES THE MGB AXIS IN PWH. TRIDENT WILL INCLUDE MULTI-LEVEL, HIGH DIMENSIONAL DATA ON THE MGB AXIS TO CATALYZE A NEW GENERATION OF PHARMACOLOGIC AND BEHAVIORAL TREATMENTS FOR DEPRESSION AND ITS NEUROBEHAVIORAL SUBSTRATES IN PWH.

ENHANCE TECHNICAL CAPACITIES OF THE NATIONAL POLICE TO INVESTIGATE SCIENCE-BASED EVIDENCE.

BUILDING RESEARCH ACROSS INTER-DISCIPLINARY GAPS (BRIDG) PROGRAM NCNM

REGULATION OF JUVENILE HORMONE TITERS IN MOSQUITOES

CHEPREO: AN INTER-REGIONAL GRID ENABLED CENTER FOR HIGH ENERGY PHYSICS AT FIU

FLORIDA INTERNATIONAL UNIVERSITY PROJECT TITLE: CONSORTIUM FOR RESEARCH AND EDUCATION IN POWER AND ENERGY SYSTEMS (CREPES) FOR SUSTAINABLE STEM WORKFORCE PROJECT DESCRIPTION: THE GOAL OF THE PROPOSED CONSORTIUM IS TO DEVELOP SUSTAINABLE AND HIGH CALIBER STEM WORKFORCE FROM THE MINORITIES AND UNDERREPRESENTED GROUPS BY PROVIDING AN INNOVATIVE RESEARCH AND EDUCATIONAL PLATFORM IN THE INTERSECTION OF LEGACY POWER SYSTEM ANALYSIS, NUCLEAR ENGINEERING, AND CYBER-PHYSICAL SYSTEMS. THE PROPOSED CONSORTIUM (CREPES) WILL ACHIEVE ITS GOAL THROUGH ACTIVITIES THAT OPERATE AT THE NEXUS OF FOUR THRUSTS: UG RESEARCH AND EDUCATION, GRADUATE RESEARCH AND EDUCATION, POST-DOC/FACULTY MENTORING, AND SUSTAINABILITY OF THE CONSORTIUM. SPECIFICALLY, THROUGH THE CREPES, WE WILL ACHIEVE THE FOLLOWING OBJECTIVES: • STRENGTHEN THE RESEARCH AND EDUCATION CAPABILITIES OF MINORITY SERVING INSTITUTIONS IN THE NSE RELATED TOPIC AREAS: THE CONSORTIUM WILL STRENGTHEN RESEARCH AND EDUCATION CAPABILITIES OF THREE MINORITY SERVING INSTITUTIONS (MSIS). THE CONSORTIUM WILL HELP STRENGTHEN UNDERGRADUATE CURRICULA OF A HISTORICALLY BLACK COLLEGES AND UNIVERSITIES: ALABAMA AGRICULTURAL AND MECHANICAL UNIVERSITY (AAMU) IN NUCLEAR ENGINEERING. THE CONSORTIUM WILL ESTABLISH A NEW NUCLEAR CERTIFICATE PROGRAM AT TWO HISPANIC SERVING INSTITUTIONS: FLORIDA INERT INTERNATIONAL UNIVERSITY (FIU) AND THE UNIVERSITY OF TEXAS AT EL PASO (UTEP), AND ALSO STRENGTHENS RESEARCH AND EDUCATION ON POWER, ENERGY, AND CYBER-PHYSICAL SYSTEM AT FIU AND UTEP. • ATTRACTS HIGH CALIBER UNDERGRADUATE, GRADUATE, DOCTORAL AND POSTDOCTORAL STUDENTS AND TRAINS THEM IN AREAS CRITICAL TO NNSA’S MISSION: THE CONSORTIUM HAS A WELL LAID OUT PLAN FOR K-12 OUTREACH, RECRUITMENT, RETENTION, PROFESSIONAL DEVELOPMENT PROGRAMS, MENTORING AND INTERNSHIP PROGRAMS (AT TWO NNSA LABS: SANDIA NATIONAL LABORATORIES AND LAWRENCE LIVERMORE NATIONAL LABORATORY), AND UP-TO-DATE RESEARCH TOPICS IN THE CORE AREA OF POWER, ENERGY, NUCLEAR ENGINEERING, AND CYBER-PHYSICAL SYSTEMS THAT WILL KEEP THE GRADUATES AHEAD IN THE COMPETITIVE JOB MARKET. THE CONSORTIUM WILL ENSURE THE GRADUATES EXCEL IN STEM BY PROVIDING THEM WITH PRACTICAL EXPERIENCE AND TRAINING THROUGH APPLICABLE RESEARCH PROJECTS, CAPACITY BUILDING, AND EXPERIENTIAL LEARNING. • PROVIDES FACULTY AND STUDENTS WITH EXPOSURE TO RESEARCHERS AND THE ENVIRONMENT OF THE NNSA NATIONAL LABORATORIES, MENTORS YOUNG RESEARCHERS AND PREPARES THEM FOR LEADERSHIP ROLES: THE CONSORTIUM HAS WELL ARTICULATED PLANS FOR THE MENTORING OF TWO JUNIOR FACULTIES AT MSIS (AT UTEP AND FIU) JOINTLY IN COLLABORATION WITH SENIOR SCIENTISTS FROM THE PARTNER NNSA NATIONAL LABS IN THE CORE AREA OF SMART GRID CYBER-PHYSICAL SYSTEMS. • ENSURES THE SUCCESS, INCREASE THE VISIBILITY AND SUSTAINABILITY OF THE CONSORTIUM: THE CONSORTIUM HAS WELL THOUGHT PLANS TO EVALUATE THE OVERALL SUCCESS OF THE RESEARCH AND EDUCATIONAL PROGRAMS. THE PIS ARE COMMITTED TO INCREASING THE VISIBILITY OF THE CONSORTIUM BY ALL POSSIBLE MEANS OF INFORMATION DISSEMINATION, NETWORKING, AND PRESENTATIONS AT TOP TIER CONFERENCES. PIS ENSURE SUSTAINABILITY OF THE CONSORTIUM THROUGH FOLLOW ON FUNDING FROM INTERNAL/EXTERNAL SOURCES.

OPTIMIZING PREP ADHERENCE IN SEXUAL MINORITY MEN WHO USE STIMULANTS

FLORIDA INTERNATIONAL UNIVERSITY ADVANCED SENSORS TECHNOLOGIES FOR APPLICATIONS IN ELECTRICAL ENGINEERING - RESEARCH AND INNOVATION EXCELLENCE CONSORTIUM (ASTERIX) ASTERIX CONSORTIUM AIMS TO ADDRESS THE NATION’S DIRE NEED FOR INCREASING THE PARTICIPATION OF UNDERREPRESENTED STUDENTS IN THE STEM WORKFORCE. THE CONSORTIUM INCLUDES INVESTIGATORS FROM FLORIDA INTERNATIONAL UNIVERSITY (FIU) - THE LARGEST HISPANIC SERVING INSTITUTION IN THE STATE OF FLORIDA, FLORIDA AGRICULTURAL AND MECHANICAL UNIVERSITY (FAMU) – THE ONLY HISTORICALLY BLACK INSTITUTION IN THE STATE OF FLORIDA, AND MIAMI-DADE COLLEGE – THE LARGEST HISPANIC SERVING COMMUNITY COLLEGE IN THE STATE OF FLORIDA. THE ASTERIX CONSORTIUM WILL BUILD A SUSTAINABLE PIPELINE OF TALENTED DIVERSE ENGINEERING STUDENTS WHO ARE HIGHLY PREPARED TO ENTER THE STEM WORKFORCE, ESPECIALLY IN AREAS OF INTEREST TO THE DEPARTMENT OF ENERGY/NATIONAL NUCLEAR SECURITY ADMINISTRATION (DOE/NNSA) ENTERPRISE. THE CONSORTIUM WILL LEVERAGE THE STRENGTHS OF EACH PARTNER INSTITUTION AND THE ESTABLISHED RESEARCH CONNECTIONS WITH DOE/NNSA INDUSTRY PARTNERS TO RECRUIT AND TRAIN ACADEMICALLY TALENTED K-20 MINORITY STUDENTS USING A VARIETY OF ACTIVITIES IN OUTREACH, EDUCATION AND RESEARCH. FURTHERMORE, THE FIU-FAMU-MDC ALLIANCE WILL SERVE ONE OF THE LARGEST POPULATIONS OF HISPANIC AND AFRICAN-AMERICAN STUDENTS IN THE NATION AND WILL CREATE INNOVATIVE ACADEMIC AND CAREER PATHWAYS FOR MINORITIES WHO WANT TO PURSUE ENGINEERING CAREERS. IN PARTICULAR THE CONSORTIUM WILL (A) RECRUIT WELL-QUALIFIED STEM STUDENTS TO SATISFY THE INCREASING DEMAND OF SCIENTISTS AND ENGINEERS IN AREAS OF INTEREST TO THE DOE, SPECIFICALLY IN ADVANCED SENSOR TECHNOLOGIES FOR VARIOUS APPLICATIONS IN ELECTRICAL ENGINEERING; (B) TRAIN STUDENTS IN UNDERGRADUATE AND GRADUATE RESEARCH AND PROVIDE ENRICHING EDUCATIONAL EXPERIENCES INCLUDING INTERNSHIP OPPORTUNITIES AT ASTERIX AND DOE LABORATORIES AND ENTERPRISES; (C) ATTRACT TALENTED UNDERREPRESENTED K-12 STUDENTS TO STEM DISCIPLINES THROUGH STRUCTURED OUTREACH ACTIVITIES AND EDUCATIONAL ENRICHMENT; AND (D) STRENGTHEN PARTNERSHIPS BETWEEN THE FIU, FAMU, AND MDC ELECTRICAL ENGINEERING DEPARTMENTS AND DOE ENTERPRISES TO TRAIN A CADRE OF SCIENTISTS AND ENGINEERS IN RESEARCH AREAS OF INTEREST TO DOE/NNSA.

LTER: COASTAL OLIGOTROPHIC ECOSYSTEM RESEARCH

TAS::57 3600::TAS "TRANSFORMING ANTENNAS CENTER" PROPOSAL DATED18 JAN 2019 (THE GRANTEE'S TECHNICAL PROPOSAL) IS HEREBY INCORPORATED BY REFERENCE.

TAS::57 3600::TAS 'CENTER FOR PHYSICALLY RECONFIGURABLE AND DEPLOYABLE MULTIFUNCTIONAL ANTENNAS' DATED 15 DEC 2017

THE CENTER FOR RESEARCH AND EDUCATION IN 2D OPTOELECTRONICS (CRE2DO) AT FLORIDA INTERNATIONAL UNIVERSITY (FIU) WILL BECOME A LEADING HUB FOR INNOVATIVE RESEARCH AND EDUCATION IN ALIGNMENT WITH NASA S STRATEGIC OBJECTIVE 3.3: INSPIRE AND ENGAGE THE PUBLIC IN AERONAUTICS SPACE AND SCIENCE AND RESONANT WITH NASA SCIENCE MISSION DIRECTORATE (SMD) PRIORITIES. THE CENTER WILL DEVELOP THE RESEARCH INFRASTRUCTURE ABLE TO ADDRESS SOME OF THE MOST IMPORTANT CHALLENGES OF SPACE EXPLORATION THROUGH STRONG PARTNERSHIPS WITH NASA CENTERS (GLENN JPL) AND PENN STATE 2D CRYSTAL CONSORTIUM. RECENTLY THE CLASS OF TWO-DIMENSIONAL (2D) MATERIALS FEATURING: TENSILE STRENGTHS HUNDREDS TIMES GREATER THAN STEEL HIGH FLEXIBILITY AND CONDUCTIVITY TREMENDOUS ENERGY STORAGE CAPACITY ETC. SHOWS THE POTENTIAL TO ADVANCE EVERY FIELD FROM ELECTRONICS TO ENERGY AND TO MEDICINE. NASA IS VESTED INTO HIGH PERFORMING NANOMATERIALS SUCH AS CARBON NANOTUBES IN SPACE TECHNOLOGIES THROUGH ITS GAME CHANGING DEVELOPMENT WHICH TARGETS ULTRA-LIGHTWEIGHT NANOMATERIALS. THE PROPOSAL OUTLINES A TECHNICAL AND EDUCATION PLAN THAT PROPELS THE 2D-FUNCTIONAL MATERIALS TO ENABLING NASA TECHNICAL ADVANCEMENTS WHILE PREPARING THE FUTURE STEM WORKFORCE.

THE PURPOSE OF THIS AGREEMENT IS TO FUND RESEARCH SUPPORTING THE DEFENSE ADVANCED RESEARCH PROJECTS AGENCY DARPA I2O OFFICE WIDE BROAD AGENCY ANNOUNCEMENT BAA. THIS EFFORT SHALL BE CARRIED OUT GENERALLY AS SET FORTH IN EXHIBIT B, RESEARCH DESCRIPTION DOCUMENT, DATED OCTOBER 25, 2023, AND IN THE RECIPIENTS PROPOSAL TITLED, AI-CRAFT ARTIFICIAL INTELLIGENCE CYBERSECURITY READINESS AND FUTURE TRAINING, DATED JULY 5, 2023, COPIES OF WHICH ARE IN THE POSSESSION OF BOTH PARTIES.

IMPLEMENT A PROGRAM FOR STIMULATING, STRENGTHENING, AND ANALYZING DISASTER RISK REDUCTION PROGRAMS IN THE AMERICAS

FCE LTER II: COASTAL OLIGOTROPHIC ECOSYSTEMS RESEARCH

NATURAL HAZARDS ENGINEERING RESEARCH INFRASTRUCTURE: EXPERIMENTAL FACILITY WITH TWELVE-FAN WALL OF WIND

CARES ACT RELIEF FUNDING - INSTITUTIONAL PORTION

HISPANIC-SERVING INSTITUTIONS PROGRAM (STEM)

GEAR-UP

NEW THREE YEAR DRR AWARD TO INCREASE DISASTER RISK MANAGEMENT CAPACITY ACROSS THE LAC REGION

TAS::57 3600::TAS "FIELD EMITTER ROBUST VACUUM INTEGRATED NANOELECTRONICS (FERVIN)" DATED 17 MAR 2019

UNIVERSITY TRANSPORTATION CENTER

IRNC: RXP: ATLANTICWAVE-SOFTWARE DEFINED EXCHANGE: A DISTRIBUTED INTERCONTINENTAL EXPERIMENTAL SOFTWARE DEFINED EXCHANGE (SDX)

USAID EMPLOYMENT PATHWAYS FOR YOUTH

PURPOSE: THE PURPOSE OF THIS GRANT IS TO ENHANCE THE WINDSTORM RESEARCH INSTRUMENTATION AND TESTING (WRITE) CAPABILITIES AT FLORIDA INTERNATIONAL UNIVERSITY (FIU) BY (1) EXPANDING THE EXISTING WALL OF WIND (WOW) CAPACITY FOR FUTURE CLIMATE SCENARIO SIMULATION AND TESTING, PARTICULARLY FOR EXTREME CATEGORY 5 STORMS, THROUGH A COMPREHENSIVE INSTRUMENTATION UPGRADE AND INTEGRATION PROGRAM USING A COMPLEMENTARY WIND ONLY PHYSICAL DESIGN TESTBED (WOPDT) WITH 200 MPH WIND SPEED GENERATION AND TRANSIENT WIND SIMULATION CAPABILITY AND (2) DEVELOPING AND IMPLEMENTING A TARGETED RESEARCH AND TESTING AGENDA TO ADDRESS FUTURE BUILT ENVIRONMENT WINDSTORM RESILIENCE NEEDS, INCLUDING COST-EFFECTIVE TECHNIQUES TO IMPROVE THE RESILIENCE OF RESIDENCES, BUSINESSES, AND CRITICAL INFRASTRUCTURE.ACTIVITIES TO BE PERFORMED: THE ACTIVITIES TO BE PERFORMED ARE DIVIDED INTO TWO PARTS: INSTRUMENTATION AND TESTING ENHANCEMENTS AND RESEARCH CAMPAIGN. ENHANCEMENTS INCLUDE (1) FLOW FIELD SIMULATION AND MEASUREMENT UPGRADES (REPLACING AGING ANEMOMETERS; IMPROVING EXPERIMENTAL FACILITY (EF) SPIRES AND FLOOR ROUGHNESS TO INCREASE THE BREADTH OF SIMULATED ATMOSPHERIC BOUNDARY LAYER; IMPROVING WATER FLOW CAPACITY FOR WIND-DRIVEN RAIN (WDR) SIMULATION; AND UPGRADING WOW EF CONTROL SYSTEM); (2) EXPERIMENTAL MEASUREMENT UPGRADES (REPLACING OUTDATED PRESSURE MEASUREMENT AND DATA ACQUISITION SYSTEMS, PROCURING AND INSTALLING NEW TURNTABLE POSITION FEEDBACK TO IMPROVE CONTROL AND AUTOMATION OF TURNTABLE OPERATION, PROCURING A NEW METEOROLOGICAL PRECIPITATION SPECTROMETER TO IMPROVE PRECIPITATION MEASUREMENT, HIGH-DEFINITION (HD) CAMERA SYSTEMS, PIV DAQ COMPUTER, AND AN INFRARED (IR) CAMERA SYSTEM TO RECORD DISPLACEMENT TIME HISTORIES ON TEST SPECIMENS); (3) EF SUPPORT STRUCTURE UPGRADES (IMPROVING ATMOSPHERIC BOUNDARY LAYER WIND TUNNEL (ABLWT) TO SUPPORT WOW ACTIVITIES AND PROCURING 3D PRINTERS TO PROTOTYPE TEST ASSEMBLIES); (4) TRAINING AND MAINTENANCE ON NEW INSTRUMENTATION, AND (5) INTEGRATION OF THE WIND-ONLY PHYSICAL DESIGN TESTBED (WOPDT) TO THE EXISTING WOW INFRASTRUCTURE TO SIGNIFICANTLY ENHANCE THE WIND SPEED SIMULATION AND TESTING CAPABILITIES. THE RESEARCH CAMPAIGN FOCUSES ON FUTURE WIND RESILIENCE NEEDS FOR THE BUILT AND NATURAL ENVIRONMENTS. THE ACTIVITIES ARE TO CONDUCT RESEARCH ON (1) WIND FLOW FIELD DEVELOPMENT OF VERTICALLY SEPARATED FLOWS, (2) ESTIMATION OF THE VULNERABILITY OF BALLASTED ROOFTOP PHOTOVOLTAIC SYSTEMS, AND (3) THREE MORE PROJECTS WITH THEMES ON VULNERABILITY OF BUILDINGS AND INFRASTRUCTURE AND COMMUNITY RESILIENCE TO BE FINALIZED DURING THE FIRST YEAR OF THIS RESEARCH PROGRAM.EXPECTED OUTCOMES: THE EXPECTED OUTCOMES ARE TO LOWER THE HUMAN AND ECONOMIC IMPACTS OF WIND HAZARD EVENTS AND TO HELP CREATE SAFER AND MORE SUSTAINABLE COASTAL COMMUNITIES.INTENDED BENEFICIARIES: COMMUNITIES SUBJECT TO WINDSTORMS AND HURRICANES WILL BENEFIT FROM THIS RESEARCH WHICH WILL CREATE IMPORTANT KNOWLEDGE THAT CAN BE UTILIZED IN EMERGENCY RESPONSE TOOLS, MITIGATION STRATEGIES, AND WINDSTORM RESISTANT BUILDING CODES AND STANDARDS TO HELP PREVENT FUTURE WIND HAZARD EVENTS FROM BECOMING DISASTERS. IN ADDITION, THIS RESEARCH PROGRAM WILL PROVIDE OPPORTUNITIES TO TRAIN POST-DOCTORAL RESEARCHERS AND GRADUATE AND UNDERGRADUATE STUDENTS IN THE LARGEST HISPANIC MINORITY SERVING INSTITUTION (MSI).SUBRECIPIENT ACTIVITIES: THE RECIPIENT PLANS TO SUBAWARD FUNDS TO ASSIST THE INTEGRATION OF THE WIND-ONLY PHYSICAL DESIGN TESTBED (WOPDT) TO THE EXISTING WOW INFRASTRUCTURE TO SIGNIFICANTLY ENHANCE THE WIND SPEED SIMULATION AND TESTING CAPABILITIES.

MOLECULAR & BEHAVIORAL EFFECTS OF LOW LEVEL MN EXPOSURE

BUILDING INCLUSIVE ENVIRONMENTS PROJECT: INTEGRATING ACADEMIC, SOCIAL, AND EMOTIONAL SKILL DEVELOPMENT

THE NU PEER NAVIGATOR NETWORK

WET SEASON AQUATIC FAUNA AND PRIMARY PRODUCTION STUDY IN FLORIDA EVERGLADES. BASE PLUS 4 OPTION YEARS FOR JACKSONVILLE DISTRICT USACE.

MRI: DEVELOPMENT OF AN INTEGRATED NEUROIMAGING INSTRUMENT WITH TEMPORAL AND SPATIAL ALIGNMENTS FOR BRAIN RESEARCH

NURSE EDUCATION, PRACTICE, QUALITY AND RETENTION

FIU-2D CRYSTAL CONSORTIUM PARTNERSHIP FOR RESEARCH AND EDUCATION IN MATERIALS

SUPPORTING TREATMENT ADHERENCE FOR RESILIENCE AND THRIVING (START): A MHEALTH INTERVENTION TO IMPROVE ART ADHERENCE FOR HIV-POSITIVE STIMULANT USING MEN - DIVERSITY SUPPLEMENT

FLORIDA INTERNATIONAL UNIVERSITY MARC U*STAR PROGRAM

IRNC: CORE IMPROVEMENT: AMERICAS-AFRICA LIGHTPATHS EXPRESS AND PROTECT (AMLIGHT-EXP)

BEHAVIORAL HEALTH WORKFORCE EDUCATION AND TRAINING (BHWET) PROGRAM

INTERVENTIONS FOR ENGLISH LANGUAGE LEARNERS AT-RISK FOR ADHD

INCLUSIVE CONSORTIUM OF LEADERS IN URBAN DISABILITIES EDUCATION (PROJECT INCLUDE)

INVESTIGATING THE RISK OF HUMAN DISEASE FROM PARASITES OF SMALL MAMMALS AND BITES.

INFORMING BIOSURVEILLANCE: CONTRIBUTION OF PTEROPODID FRUIT BATS TO VIRUS SPILLOVER IN THE PHILIPPINES

PROJECT DIG: FIU-MDCPS COLLABORATIVE PARTNERSHIP TO SUPPORT SCHOOL-BASED MENTAL HEALTH PROVIDERS

ADVANCED NURSE EDUCATION-SEXUAL NURSE ASSAULT EXAMINER PROGRAM

CARES ACT STIMULUS FUNDING FOR HIGHER EDUCATION INSTITUTIONS

TAMIU HEERF MSI CARES

GENE DEREGULATION IN CORTICAL DEMENTIA

SPECIAL EDUCATION RESEARCH

PREVENTIVE INTERVENTION FOR BEHAVIOR PROBLEMS IN INFANTS FROM HIGH-RISK FAMILIES

MRI: DEVELOPMENT OF AN INSTRUMENT FOR A COMPREHENSIVE STUDY OF ALZHEIMER'S DISEASE: MULTIMODAL IMAGING, VISUALIZATION, MACHINE LEARNING AND THERAPEUTIC BRAIN STIMULATION

A DEVELOPMENTALLY-SENSITIVE MECHANISM UNDERLYING THE ESCALATION OF ADOLESCENT SOCIAL ANXIETY - ABSTRACT SOCIAL ANXIETY DISORDER (SAD) IS A CHRONIC, IMPAIRING CONDITION THAT TYPICALLY EMERGES DURING ADOLESCENCE AND AFFECTS ABOUT 10% OF THE POPULATION. TREATMENT RESPONSE RATES FOR SAD ARE MARKEDLY LOWER THAN FOR OTHER ANXIETY DISORDERS, THUS PRESENTING AN URGENT NEED TO IDENTIFY NOVEL THERAPEUTIC TARGETS THAT CAN INFORM NEW INTERVENTIONS FOR THIS DIFFICULT-TO-TREAT DISORDER. WE PROPOSE TO ADDRESS THIS NEED BY TESTING A DEVELOPMENTALLY-INFORMED, MECHANISTIC MODEL OF THE ESCALATION OF IMPAIRING SOCIAL ANXIETY SYMPTOMS (SA) IN EARLY-TO-MID ADOLESCENCE; OUR MODEL CENTERS ON FEAR OF NEGATIVE EVALUATION (FNE) AND HYPERVIGILANCE FOR ERRORS IN THE PRESENCE OF PEERS, WITH A FOCUS ON FRONTAL BRAIN OSCILLATIONS AS CENTRAL TO THIS ESCALATION. ADOLESCENCE REPRESENTS A SENSITIVE PERIOD FOR THE DEVELOPMENT OF SOCIAL COGNITION AND COGNITIVE CONTROL. AT THE PSYCHOLOGICAL LEVEL, SOCIAL FEARS AND FNE EXHIBIT NORMATIVE INCREASES ACROSS ADOLESCENCE, GIVEN THE INCREASING IMPORTANCE OF PEERS DURING THIS DEVELOPMENTAL WINDOW. AT THE NEURAL LEVEL, FRONTAL BRAIN SYSTEMS UNDERLYING SOCIAL COGNITION AND COGNITIVE CONTROL EXHIBIT PROTRACTED DEVELOPMENT ACROSS ADOLESCENCE, INCLUDING DEVELOPMENT OF THE FRONTAL CORTEX AND ASSOCIATED 4-8 HZ “THETA” OSCILLATIONS CAUSALLY IMPLICATED IN COGNITIVE CONTROL. OUR CENTRAL HYPOTHESIS IS THAT ADOLESCENT INCREASES IN FNE, ALONGSIDE DEVELOPMENT OF THE FRONTAL CORTEX, CREATE A MALADAPTIVE FEEDBACK LOOP: ADOLESCENTS BECOME HYPERVIGILANT TO ERRORS IN SOCIAL SETTINGS, FURTHER INCREASING FNE, AND ULTIMATELY, IMPAIRING SA. OUR MODEL PREDICTS (AIM 1) THAT DEVELOPMENTAL INCREASES IN FNE LEAD TO INCREASED CONCERNS OVER PERFORMANCE IN THE PRESENCE OF PEERS, WHICH IN TURN AMPLIFIES HYPERVIGILANCE FOR ERRORS (THAT IS, INCREASED STRENGTH OF ERROR-RELATED THETA OSCILLATIONS). WE FURTHER PREDICT (AIM 2) THAT INCREASED HYPERVIGILANCE FOR ERRORS LEADS TO MORE CRITICAL SELF- EVALUATIONS AND CONFIRMATIONS OF INITIAL FEARS, WHICH WORSEN FNE/SA OVER TIME. MOREOVER, WE PREDICT ADOLESCENTS WHO EXHIBIT GREATER SYNCHRONY IN THETA OSCILLATIONS ACROSS MEDIAL-LATERAL FRONTAL CORTEX ARE AT GREATEST RISK AND WILL DISPLAY THE LARGEST INCREASES IN FNE/SA. TO TEST OUR MODEL, WE WILL COLLECT AN ACCELERATED LONGITUDINAL STUDY OF 256 ADOLESCENTS, SPANNING AGES 11-15, BIOLOGICALLY MALE/FEMALE, AND RANGING IN FNE/SA. PARTICIPANTS WILL COMPLETE A MODIFIED COGNITIVE CONTROL TASK IN PEER PRESENCE/ABSENCE (VIA ZOOM) AS EEG IS RECORDED. WITH AN EYE TOWARD FUTURE TRANSLATIONAL WORK, WE WILL ALSO (AIM 3) ESTABLISH THE ECOLOGICAL VALIDITY OF OUR NEURAL MEASURES BY TESTING LINKS TO MICRO-CODED BEHAVIORS INDICATIVE OF SA WITHIN A SOCIAL INTERACTION TASK. GIVEN THAT ESCALATION OF SA OCCURS DURING PUBERTY AND WITHIN A BROADER SOCIAL CONTEXT, WE WILL ALSO MEASURE, CONTROL FOR, AND EXPLORE THE POSSIBLE MODERATING ROLES OF PUBERTY, AS WELL AS EFFECTS OF SOCIAL AND DEMOGRAPHIC VARIABLES. A KEY STRENGTH OF THIS PROPOSAL IS THAT OUR TEAM HAS A PROVEN RECORD IN DEVELOPMENTAL PSYCHOPATHOLOGY AND EXPERIMENTAL THERAPEUTICS, PROVIDING A CLEAR PATH FOR TRANSLATING FINDINGS FROM THIS PROJECT INTO NOVEL, BRAIN-BASED THERAPEUTICS AND THEREBY SHORTENING THE DISTANCE “FROM BENCH TO BEDSIDE.”

CESU- SOFL - AN AGREEMENT TO PROVIDE HIGHLY SPECIALIZED TECHNICAL AND OPERATIONAL SUPPORT TO ADVANCE EVERGLADES RESTORATION INITIATIVES

EXAMINING TOLERANCE TO CNS STIMULANTS IN ADD

ADAPTIVE RESPONSE TO INTERVENTION (RTI) FOR STUDENTS WITH ADHD

HIGHER EDUCATION - INSTITUTIONAL AID - STRENGTHENING INSTITUTIONS - HISPANIC SERVING INSTITUTIONS

STRENGTHENING INSTITUTIONS - HISPANIC SERVING INSTITUTIONS

THE DISASTER RESILIENCE AND CLIMATE IN THE AMERICAS PROGRAM

NANOTECHNOLOGY BASED GENE EDITING TO ERADICATE HIV BRAIN RESERVOIR IN DRUG ABUSERS

ADVANCE INSTITUTIONAL TRANSFORMATION AT FLORIDA INTERNATIONAL UNIVERSITY

EFFECT?OF?SOLUBLE?CORN?FIBER?SUPPLEMENTATION?FOR?1?YEAR?ON?BONE?METABOLISM?IN?ADOLESCENTS (META-BONE TRIAL)

INSTITUTIONAL PORTION OF HEERF/CARES ACT

POLYDRUG NANOCARRIER TO TREAT OPIATE ADDICTION AND HIV DISEASE

MBRS SUPPORT OF CONTINUOUS RESEARCH EXCELLENCE AT FIU

IMMUNOPROTEASOME INHIBITORS FOR THE TREATMENT OF ALZHEIMER?S DISEASE - PROJECT SUMMARY WITH THE FAILURE OF NEARLY ALL CLINICAL TRIALS FOR AD DRUGS IN THE PIPELINE TO DATE, IDENTIFICATION OF A NEW CLASS OF DRUG CANDIDATES HAS BECOME IMPERATIVE TO BRING ABOUT EFFECTIVE AD THERAPIES. A MAJOR OBSTACLE IS THE LACK OF PROMISING NEW DRUG TARGETS UNRELATED TO THE EVENTS LEADING TO THE ACCUMULATION OF THE AMYLOID-BETA (ASS) AND TAU- PROTEIN. WE RECENTLY REPORTED THAT LINEAR PEPTIDE EPOXYKETONES TARGETING THE IMMUNOPROTEASOME (IP), AN INDUCIBLE VARIANT OF THE 20S CONSTITUTIVE PROTEASOME (CP), MAY REPRESENT A NEW CLASS OF AD DRUGS THAT CAN AMELIORATE COGNITIVE DEFICITS, INDEPENDENTLY OF ASS OR TAU ACCUMULATION. WHILE DISPLAYING PROMISING EFFICACY, HOWEVER, THE PROSPECT OF THESE LINEAR PEPTIDE EPOXYKETONES FOR CLINICAL USE IN AD APPEARS LIMITED AT THIS TIME, DUE TO POTENTIAL ISSUES OF HAVING A POOR BRAIN ACCESSIBILITY, IN VIVO METABOLIC INSTABILITY, AND SHORT CIRCULATION TIME (LARGELY ATTRIBUTABLE TO THE ABCB1-MEDIATED DRUG EFFLUX AT THE BBB AND ENZYMATIC HYDROLYSIS BY PEPTIDASES AND EPOXIDE HYDROLASES). YET, THE FAMILY OF PEPTIDE EPOXYKETONES (‘SHORT PEPTIDES WITH C-TERMINAL A',SS'-EPOXYKETONE WARHEAD’) REMAIN ATTRACTIVE DRUG CANDIDATES CONSIDERING THEIR PHARMACOLOGICAL ADVANTAGES CONFERRED BY THEIR PROVEN TARGET SPECIFICITY FOR THE PROTEASOMES AND LONG-TERM SAFETY IN THE CLINIC. OUR CURRENT FINDINGS REVEAL THAT SOME OF THE PEPTIDE EPOXYKETONE FAMILY MEMBERS CONTAINING A MACROCYCLE HAVE THE ABILITY TO RESIST THE ABCB1-MEDIATED EFFLUX AND METABOLIC STABILITY SUPERIOR TO THEIR LINEAR COUNTERPARTS, AND THE POTENTIAL TO BE A MEANINGFUL NEW TREATMENT FOR PATIENTS WITH AD. OUR OBJECTIVE IN THIS APPLICATION IS TO IDENTIFY AND CHARACTERIZE ONE OF THESE MACROCYCLIC COMPOUNDS BEST SUITED FOR BRAIN IP INHIBITION IN VIVO AND PROCEED TO THE NEXT PHASE OF DRUG DEVELOPMENT. TO DO THIS, IN AIM 1 WE WILL PREPARE THE CURRENT SETS OF PROMISING MACROCYCLIC PEPTIDE EPOXYKETONES WITH DIFFERENT STRUCTURAL FEATURES THAT DISPLAYED COMPARABLE TARGET INHIBITION AND BIOLOGICAL ACTIVITY IN VITRO AND IN CELLULO ON A GRAM SCALE. IN AIM 2, WE WILL CHARACTERIZE IN VIVO PROPERTIES OF EACH MACROCYCLIC PEPTIDE EPOXYKETONE TO IDENTIFY A LEAD DRUG CANDIDATE. IN AIM 3, WE WILL VERIFY IN VIVO EFFICACY AND THE PROPOSED MECHANISM OF ACTION OF THE LEAD DRUG CANDIDATE [IP INHIBITION (NLRP3 INFLAMMASOME) SUPPRESSION OF MICROGLIAL IL-1A RELEASE BLOCKADE OF ASTROCYTES TRANSFORMATION (TO A1 SUBTYPE) NEURONAL SURVIVAL] USING TWO MOUSE MODELS OF AD (APP/PS1 AND PS19 TAU TRANSGENIC MICE). BY COMPLETING THE PROPOSED STUDY, WE WILL HAVE IDENTIFIED A LEAD CANDIDATE WITH THE BEST ATTRIBUTES FOR IND ENABLING STUDIES AND NOVEL MODE OF ACTION. THESE RESULTS ARE EXPECTED TO HAVE AN IMPORTANT POSITIVE IMPACT BY EXAMINING THE VALIDITY OF THE PREVIOUSLY UNTAPPED IP-TARGETING APPROACH FOR AD THERAPY AND POTENTIALLY OFFERING A NEW DIRECTION FOR AD DRUG DISCOVERY.

DISASTERS, SOLAR ENERGY, AND CHRONIC DISEASE MANAGEMENT IN AGING PUERTO RICANS - PROJECT SUMMARY PUERTO RICO (PR) FACES FREQUENT POWER OUTAGES DUE TO DAMAGE CAUSED BY NATURAL DISASTERS TO ITS ELECTRIC GRID. AGING PUERTO RICANS (=50 YEARS) ARE A VULNERABLE POPULATION DURING NATURAL DISASTERS AS THEY ARE MORE LIKELY TO HAVE MULTIPLE CHRONIC HEALTH CONDITIONS WHEN COMPARED TO OTHER NON-HISPANIC WHITES AND OTHER HISPANIC GROUPS IN THE US. POWER OUTAGES CAN INCREASE THESE DISPARITIES, AND ELEVATE MORBIDITY AND MORTALITY DUE TO CO- MORBID CONDITIONS. RESEARCH HAS DEMONSTRATED THAT ENERGY INDEPENDENCE HAS POSITIVE HEALTH IMPACTS. ENERGY INDEPENDENCE THROUGH DIRECT ACCESS TO SOLAR POWER HAS BEGUN TO APPEAR IN PR THROUGH THE WORK OF THE NON- PROFIT COMMUNITY ORGANIZATION CASA PUEBLO (CP). WE PROPOSE TO EXPLORE, FROM A MULTILEVEL PERSPECTIVE, THE FACTORS THAT ENABLE LOCAL GOVERNMENT AGENCIES, COMMUNITIES AND INDIVIDUALS TO ADAPT TO ENERGY INDEPENDENCE IN THEIR SETTINGS, AND THEIR IMPLICATIONS FOR CHRONIC DISEASE MANAGEMENT VIA THESE AIMS: AIM 1 – THROUGH OUR PARTNERSHIP WITH CP, EXPLORE THE PROCESS EXPERIENCED BY COMMUNITIES AND THE AGING POPULATION (=50 YEARS) LIVING WITH CHRONIC DISEASES WHILE ADAPTING TO ENERGY INDEPENDENCE (E.G., INTRODUCTION OF THE TECHNOLOGY, TRAINING ON ITS USE, ACCESS TO ENERGIZED COMMUNAL POINTS) IN ORDER TO BETTER UNDERSTAND HOW COMMUNAL CHARACTERISTICS (E.G., COLLECTIVE IDENTITY, PERCEIVED INDIVIDUALISM) CAN HINDER OR FOSTER CDM AMONG THOSE WITH RENAL DISEASE, RESPIRATORY DISEASE, AND DIABETES. AIM 2 – SYSTEMATICALLY DOCUMENT FROM A MULTILEVEL PERSPECTIVE (I.E., INDIVIDUAL, COMMUNITY AND STRUCTURAL) THE PERCEIVED BARRIERS AND FACILITATORS FOR ADOPTING ENERGY INDEPENDENCE STRATEGIES IN PR. AIM 3 – DOCUMENT RESILIENCE RELATED VARIABLES AT THE INDIVIDUAL LEVEL (E.G., SELF-EFFICACY, POSITIVE ATTITUDES, KNOWLEDGE, ALTRUISM), COMMUNAL (E.G., EMOTIONAL CONNECTION, GROUP MEMBERSHIP), AND STRUCTURAL (I.E., POWER OUTAGES, GEOGRAPHICAL VARIABLES) LEVELS THAT CAN FOSTER EFFECTIVE CDM AMONG AGING POPULATIONS IN NEED OF ELECTRICITY-BASED TREATMENTS (I.E., RENAL DISEASE, RESPIRATORY DISEASES, DIABETES). TO ACHIEVE AIM 1 AND 2, WE WILL CONDUCT: (A) A DETAILED ETHNOGRAPHIC OBSERVATION/MAPPING OF CP, INVOLVING 30 MONTHS OF IMMERSIVE AND ONGOING INSTITUTIONAL EXCHANGE AND (B) A MULTILEVEL ANALYSIS OF THE COMMUNITY-BASED ENERGY INDEPENDENCE THROUGH 45 TIERED IN-DEPTH INTERVIEWS WITH INDIVIDUALS =50 YEARS WITH A RANGE OF ACCESS TO CP’S SOLAR INSTALLATIONS: 1) DIRECT ACCESS (N=15), INDIRECT ACCESS (N=15) AND NO ACCESS (N=15). IN ADDITION, WE WILL CONDUCT QUALITATIVE INTERVIEWS WITH INDIVIDUALS ENGAGED AT THE POLICY-, ADMINISTRATIVE- OR TECHNICAL-LEVELS WORKING WITHIN THE FIELD OF SUSTAINABLE ENERGY AND DISASTER RECOVERY (N=15). TO ACHIEVE AIM 3, WE WILL ADMINISTER A SURVEY TO A SAMPLE OF 345 AGING PERSONS IN THE TOWN OF ADJUNTAS WHO HAVE DIRECT, INDIRECT AND NO ACCESS TO INDEPENDENT ENERGY SOURCES. OUR RESEARCH WILL CONTRIBUTE TO POLICY DEVELOPMENT AND DISSEMINATION REGARDING THE ROLE OF COMMUNITY ENGAGEMENT AND ENERGY INDEPENDENCE IN MANAGING CHRONIC DISEASES AMONG AGING POPULATIONS IN AREAS OF THE UNITED STATES AND THE CARIBBEAN THAT ARE VULNERABLE TO HEALTH INEQUITIES MAGNIFIED BY DISASTERS.

HEMISPHERE CENTER FOR ENVIRONMENTAL TECHNOLOGY

MECHANISMS OF ARSENICAL TRANSPORT

ELECTROPRODUCTION OF STRANGE PARTICLES AT JEFFERSON LAB

NOVEL RORGAMMA ANTAGONISTS FOR INFLAMMATION AND AUTOIMMUNE DISEASE

A NOVEL APPROACH TO STIMULANT-INDUCED WEIGHT SUPPRESSION AND ITS IMPACT ON GROWTH

SINGLE AND COMBINED EFFECTS OF POSITIVE BEHAVIOR SUPPORT, MEDICATION AND ACADEMIC ACCOMMODATION FOR CHILDREN WITH ADHD - CHILDREN WITH ATTENTION-DEFICIT/HYPERACTIVITY DISORDER (ADHD) EXPERIENCE PROFOUND, SUSTAINED, AND SEVERE IMPAIRMENTS IN ACADEMIC FUNCTIONING AND LONG-TERM PROGRESS, MAKING THE IDENTIFICATION AND EVALUATION OF EFFECTIVE APPROACHES CRITICAL. THEREFORE, IT IS SURPRISING THAT SUCH LITTLE EMPIRICAL WORK HAS EXPLORED EFFECTIVE INTERVENTION APPROACHES RELATED TO LEARNING. THIS PROPOSAL WILL INVESTIGATE THE EFFICACY OF COMMON ACADEMIC ACCOMMODATIONS (EXTRA TIME, FREQUENT BREAKS, LOW-DISTRACTION ENVIRONMENT, AND ADAPTIVE FURNITURE) PROVIDED FOR CHILDREN WITH ATTENTION- DEFICIT/HYPERACTIVITY DISORDER (ADHD) AS WELL AS CLASSROOM BEHAVIOR MANAGEMENT POSITIVE SUPPORTS AND MEDICATION. THERE HAS NOT YET BEEN A RIGOROUS TRIAL THAT INVESTIGATES THESE INTERVENTIONS ALONE AND IN COMBINATION WITH ONE ANOTHER FOR CHILDREN WITH ADHD IN STANDARD EDUCATIONAL SETTINGS. THUS, IN THIS PROPOSED STUDY, THE EFFICACY OF COMMONLY EMPLOYED ACADEMIC ACCOMMODATIONS, BEHAVIORAL SUPPORT INTERVENTIONS, AND MEDICATION WILL BE RIGOROUSLY EVALUATED IN A WITHIN-SUBJECT DESIGN IN A CLASSROOM SETTING CONDUCTED UNDER WELL- CONTROLLED CONDITIONS IN A SUMMER TREATMENT PROGRAM SETTING. SPECIFIC AIMS FOR THE PROJECT INCLUDE AN EVALUATION OF THE SINGLE AND COMBINED EFFECTS OF BEHAVIORAL SUPPORTS, MEDICATION, AND ACADEMIC ACCOMMODATIONS. FURTHER, THE MODERATING EFFECT OF CHILD CHARACTERISTICS USING STANDARD DIAGNOSTIC PROCEDURES AS WELL AS BASELINE NEUROCOGNITIVE FUNCTIONING WILL BE EXPLORED. PARTICIPANTS WILL BE 288 CHILDREN (GRADES K-5; 72 PER YEAR FOR FOUR YEARS; 36 PER SITE), DIAGNOSED WITH ADHD. AT BASELINE, INFORMATION ON COMORBIDITIES (SPECIFIC LEARNING DISABILITY, DISRUPTIVE BEHAVIOR DISORDER) AND NEUROCOGNITIVE IMPAIRMENTS (PROCESSING SPEED, WORKING MEMORY, REACTION TIME VARIABILITY, INHIBITORY CONTROL AND ATTENTION) WILL BE MEASURED AND EVALUATED AS MODERATORS. THEN, IN A WITHIN-SUBJECT DESIGN, ALL CHILDREN WILL RECEIVE EACH LEVEL OF THE BEHAVIOR MODIFICATION ACCOMMODATIONS (I.E., NO POSITIVE BEHAVIORAL SUPPORTS, POSITIVE BEHAVIORAL SUPPORTS), EACH LEVEL OF MEDICATION (I.E., PLACEBO, .3 MG/KG METHYLPHENIDATE) AND EACH LEVEL OF THE ACADEMIC ACCOMMODATIONS (I.E., EXTENDED TIME, ADAPTIVE FURNITURE, FREQUENT BREAKS, PREFERENTIAL/LOW DISTRACTION SEATING VS. A STANDARD CLASSROOM ENVIRONMENT). MEASURES OF KEY OUTCOME WILL INCLUDE OBJECTIVE MEASURES OF BEHAVIORAL AND ACADEMIC FUNCTIONING. THESE INCLUDE OBSERVATIONS OF BEHAVIOR IN THE CLASSROOM (I.E., ON-TASK BEHAVIOR) AND ACADEMIC PRODUCTIVITY (I.E., WORK COMPLETION) IN INDEPENDENT SEATWORK AND GROUP INSTRUCTION SETTINGS.

NANO-DELIVERY OF METHANANDAMIDE ACROSS BBB TO BLOCK CANNABINOID INDUCED EFFECTS IN HIV-1 INFECTION

PARENT MEDIATION OF CHILD ANXIETY CBT OUTCOME

TAMIU ACADEMIC AND INDUSTRY READINESS IN ENGINEERING AND SCIENCE (AIRES)

ASPIRATIONAL (ALIGNING SCHOLARS AND PROFESSIONALS WITH INTERVENTIONS, RESOURCES, AND ACCESSING TRAINING AND INFORMATION FOR OPTIMIZING A NATIONAL ALLIANCE OF LEADERS) CENTER FOR TRANSFORMATION (ACT)

FLORIDA INTERNATION UNIVERSITY PROJECT TITLE: CONSORTIUM FOR RESEARCH AND EDUCATION IN CYBER MANUFACTURING APPLICATIONS FOR MODULAR NUCLEAR REACTORS (CMA-MNUR) PROJECT OBJECTIVE: RESEARCH: IN THIS PROJECT, THE RESEARCH ACTIVITIES ARE ORGANIZED IN THREE THEMES: • THEME-1 CYBER MANUFACTURING ENVIRONMENT AND SENSING TECHNOLOGY DEVELOPMENT; • THEME-2 ADVANCING THE ADDITIVE MANUFACTURING TECHNOLOGIES; • THEME-3 NUCLEAR DETECTION AND SECURITY. WE WILL LEVERAGE OUR EXPERTISE IN ADDITIVE MANUFACTURING (AM), STRUCTURAL HEALTH MONITORING (SHM), PROCESS MONITORING AND SIMULATION, ARTIFICIAL INTELLIGENCE (AI) AND MACHINE LEARNING (ML), AND MECHANICAL CHARACTERIZATION TO DEVELOP HIGH-QUALITY CYBER MANUFACTURING CAPABILITIES FOR METAL PARTS WITH AND WITHOUT SENSING OPTIONS. THE MAIN RESEARCH SCOPE INCLUDES ADVANCING THE STATE-OF-THE-ART IN 3D PRINTING PROCESS MONITORING AND MODELING; DEVELOPING SHM TECHNIQUES FOR ADDITIVELY MANUFACTURED PARTS; APPLYING AI TO ENABLE CYBER MANUFACTURING CAPABILITIES FOR HIGH-QUALITY PARTS; DEVELOP NUCLEAR DETECTION AND MONITORING CAPABILITIES FOR NUCLEAR REACTOR SECURITY.

COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - CONSTRUCTION

WATERSCAPES: SCIENCE OF COUPLED AQUATIC PROCESSES IN ECOSYSTEMS FROM SPACE IS A PROPOSED NASA GROUP 4 UNIVERSITY RESEARCH CENTER (URC) BASED AT FLORI

NETWORK FOR ENHANCING WELLNESS IN DISASTER-AFFECTED YOUTH (NEW DAY) - THE NETWORK FOR ENHANCING WELLNESS IN DISASTER-AFFECTED YOUTH (NEW DAY) BRINGS TOGETHER A NATIONAL CONSORTIUM OF LEADING EXPERTS IN DISASTER RECOVERY AND CHILDREN'S MENTAL HEALTH TO COLLABORATE WITH DISASTER-PRONE REGIONAL COALITIONS AND OTHER KEY STAKEHOLDERS TO EXPAND THE SCOPE, REACH, AND EQUITY OF EVIDENCE-BASED INTERVENTIONS FOR YOUTH EXPOSED TO DISASTERS, MASS VIOLENCE, AND PUBLIC HEALTH CRISES. DISASTERS CARRY A VERY BROAD, HEAVY, AND SUSTAINED MENTAL HEALTH BURDEN, AND YOUTH (0-21) ARE PARTICULARLY VULNERABLE. DESPITE ADVANCES IN DISASTER MENTAL HEALTH, YOUTH-SERVING PROFESSIONALS IN MOST DISASTER-AFFECTED REGIONS TYPICALLY LACK ADEQUATE TRAINING AND PREPARATION TO PROVIDE NEEDED INTERVENTION AND SUPPORT TO DISASTER-AFFECTED YOUTH. HEADQUARTERED AT FLORIDA INTERNATIONAL UNIVERSITY'S PREEMINENT CENTER FOR CHILDREN AND FAMILIES, PROJECT NEW DAY WILL ADDRESS KEY GAPS AND ADVANCE TRAINING, EDUCATION, AND TECHNICAL ASSISTANCE IN YOUTH DISASTER RESPONSE BY ACHIEVING FIVE OVERARCHING GOALS: (1) FOSTER AND MAINTAIN A STRATEGIC NETWORK AND SEVERAL COLLABORATIVE ADVISORY COALITIONS TO ADVISE PROJECT EFFORTS TO IMPROVE YOUTH DISASTER BEHAVIORAL RESPONSE; (2) INCREASE THE AVAILABILITY OF THREE EVIDENCE-BASED, TRAUMA-FOCUSED INTERVENTIONS FOR ADDRESSING YOUTH BEHAVIORAL HEALTH IN THE CONTEXT OF DISASTERS [I.E., PSYCHOLOGICAL FIRST AID (PFA)/PFA FOR SCHOOLS, SKILLS FOR PSYCHOLOGICAL RECOVERY (SPR), CHILD ADULT RELATIONSHIP ENHANCEMENT (CARE) AFTER DISASTERS]; (3) INCREASE PROFESSIONAL KNOWLEDGE, SKILL, ADOPTION AND IMPLEMENTATION OF PFA/PFA-S, SPR, & CARE AFTER DISASTERS AMONG YOUTH-SERVING PROFESSIONALS AND SYSTEMS OF CARE IN DISASTER-AFFECTED COMMUNITIES; (4) REDUCE RACIAL AND ETHNIC DISPARITIES IN CHILDREN'S DISASTER BEHAVIORAL HEALTH AND SERVICE UTILIZATION; AND (5) INCREASE THE REACH AND SUSTAINABILITY OF PFA/PFA-S, SPR, & CARE IN THE AFTERMATH OF DISASTERS BY LEVERAGING SCHOOL SYSTEMS, FAMILIES, COMMUNITY AGENCIES, AND TECHNOLOGY. THESE GOALS WILL BE ACHIEVED BY REACHING A NUMBER OF MEASURABLE OBJECTIVES INCLUDING (I) PROVIDING AT LEAST 40 ON-SITE MULTI-DAY TRAININGS IN PFA/PFA-S, SPR, AND/OR CARE AFTER DISASTERS TO AT LEAST 2500 YOUTH-SERVING PROFESSIONALS IN DISASTER-AFFECTED COMMUNITIES; (II) LEAD AT LEAST 260 VIRTUAL GROUP CONSULTATIONS FOR PFA/PFA-S, SPR, AND CARE AFTER DISASTERS IMPLEMENTATION SUPPORT; (III) HOLD WEEKLY OFFICE HOURS TO OFFER 1:1 CONSULTATION AND TECHNICAL ASSISTANCE TO LOCAL LEADERS, SUPERVISOR, AND PROFESSIONALS AS THEY WORK TO IMPLEMENT, IMPROVE, OR SUSTAIN DISASTER-RELATED YOUTH PRACTICES IN THEIR SETTINGS AND NETWORKS; (IV) DEVELOP AND DISTRIBUTE A SET OF PRACTICE GUIDELINES FOR OVERCOMING BEHAVIORAL HEALTH DISPARITIES IN DISASTER-AFFECTED COMMUNITIES, WITH PARTICULAR FOCUS ON COMMUNITIES OF COLOR; (V) PRODUCE 5 PROFESSIONAL WORKSHOPS ON KEY TOPICS IN PFA/PFA-S, SPR, AND CARE AFTER DISASTERS IMPLEMENTATION FOR YOUTH; AND (VI) PRODUCE 15 PROFESSIONAL WEBINARS PER YEAR ON KEY DISASTER-AFFECTED YOUTH TOPICS. FOR MAXIMAL REACH, PROJECT NEW DAY WILL PROVIDE TRAINING, EDUCATION, AND TECHNICAL ASSISTANCE TO MENTAL HEALTH PROVIDERS AND SYSTEMS, AS WELL AS KEY YOUTH-SERVING WORKFORCES AND SYSTEMS OUTSIDE OF MENTAL HEALTH CARE AND THOSE IN MINORITY-SERVING SETTINGS.

BRIEF INTERVENTION FOR SUBSTANCE USING NATIVE YOUTH

MULTISENSORY DEVELOPMENT: NEW MEASURES AND A COLLABORATIVE DATABASE

FIU-ARC'S RESEARCH AND TECHNOLOGY DEVELOPMENT, DEMONSTRATION AND TESTING WILL BE IN THE 4 MAJOR AREAS OF ENVIRONMENTAL CLEANUP OPERATIONS: RADIOACTIVE WASTE PROCESSING, SOIL & GROUNDWATER REMEDIATION, FACILITY DECONTAMINATION AND DECOMMISSIONING AND TAILORED INFORMATION TECHNOLOGY DEVELOPMENT FOR ENVIRONMENTAL MANAGEMENT.

STUDY ON NEURODEGENERATION USING TDP-43 TRANSGENIC RATS

STUDY ON PFN1 PATHOBIOLOGY USING RAT MODELS

CARES ACT EMERGENCY FINANCIAL AID GRANTS TO STUDENTS - FLORIDA NATIONAL UNIVERSITY OPEID 02547600

MRI-R2: DEVELOPMENT OF AN INSTRUMENT FOR INFORMATION SCIENCE AND COMPUTING IN NEUROSCIENCE

CONTROL OF DNA TOPOLOGY

NRT-QISE: QUANTUM SCIENCE, TECHNOLOGY AND APPLIED RESEARCH AT FLORIDA INTERNATIONAL UNIVERSITY (Q-STAR) -THE SECOND QUANTUM REVOLUTION IS PAVING THE WAY FOR A FUTURE WITH UNPRECEDENTED TECHNOLOGICAL CAPABILITIES. THE NATIONAL QUANTUM INITIATIVE ACT CATALYZED THE DEMAND FOR A SKILLED AND DIVERSE WORKFORCE BY IDENTIFYING QUANTUM TECHNOLOGIES AS A NATIONAL PRIORITY. THE PRACTICAL REALIZATION OF EACH OF THESE TECHNOLOGIES CANNOT BE ACCOMPLISHED WITHOUT A TOOLBOX OF MATERIALS BUILDING BLOCKS THAT DISPLAY CONTROLLABLE QUANTUM PROPERTIES DEMANDED BY EACH APPLICATION. THIS NATIONAL SCIENCE FOUNDATION RESEARCH TRAINEESHIP (NRT) AWARD TO THE FLORIDA INTERNATIONAL UNIVERSITY WILL PROVIDE A COHERENT RESEARCH AND EDUCATION FRAMEWORK TO ADDRESS THESE IMPERATIVE NEEDS IN QUANTUM INFORMATION SCIENCE AND ENGINEERING (QISE) BY TRAINING GRADUATE STUDENTS FOR THE QUANTUM WORKFORCE. THE PROJECT ANTICIPATES TRAINING ONE HUNDRED AND NINETY (190) M.S. AND PH.D. STUDENTS, INCLUDING THIRTY (30) FUNDED TRAINEES, FROM MATERIALS SCIENCE AND ENGINEERING, CHEMISTRY, AND PHYSICS PROGRAMS. THE RESEARCH FOCUS OF THE NRT Q-STAR PROJECT IS ON NOVEL QUANTUM MATERIALS DISCOVERY, SYNTHESIS, MODELING, AND VALIDATION OF THEIR QUANTUM BEHAVIOR. THE EDUCATIONAL COMPONENT INVOLVES A 360-DEGREE STUDENT-CENTERED GRADUATE EDUCATION MODEL ENCOMPASSING ELEMENTS THAT DELIVER: A. TECHNICAL EXPERTISE TRAINING: THESE ELEMENTS ARE TEAM-RESEARCH PROJECTS, INTERNSHIPS AT PARTNER INSTITUTIONS, AND A DESIGNED COURSEWORK; AND B. CAREER-SUCCESS TRAINING INCLUDING THE ABILITY TO LEAD PROJECTS, WORK IN TEAMS, COMMUNICATE SCIENCE TO PUBLIC AND POLICYMAKERS, AND MAKE ETHICAL DECISIONS. SPECIFIC ELEMENTS INCLUDE TRAINING MECHANISMS TO PROMOTE LEARNING OF SCIENCE COMMUNICATION, ETHICS, AND TEAMWORK, AND A WORKSHOP ON TRANSFERABLE SKILLS INCLUDING LEADERSHIP AND ENTREPRENEURSHIP IS INCLUDED. THE PROGRAM WILL PROVIDE ALL TRAINEES A PATHWAY TOWARD TECHNICAL AND LEADERSHIP ROLES IN QISE ACROSS THE NATION. THE CONVERGENT RESEARCH WILL BRIDGE THE CHEMISTRY AND MATERIALS SCIENCE THAT WILL ENABLE NOVEL QUANTUM MATERIALS, WITH THE PHYSICS OF THE QUANTUM PHENOMENA THAT WILL RENDER THESE MATERIALS USEFUL IN FUTURE QUANTUM TECHNOLOGIES. THE DISCOVERY PROCESS WILL BE DATA-DRIVEN, USING MACHINE LEARNING AND DENSITY FUNCTIONAL THEORY (DFT) TO GUIDE EXPERIMENTS. THE SCIENTIFIC ADVANCEMENTS ANTICIPATED BY EXPLORING NOVEL NON-CENTROSYMMETRIC CHALCOGENIDE MATERIALS FOR QUANTUM FREQUENCY CONVERTERS, 2D AND 3D SEMICONDUCTOR QUBITS, AND MATERIALS FOR QUANTUM BATTERY TECHNOLOGIES WILL BE COMPLEMENTED BY NEW KNOWLEDGE GAINED THROUGH THE IMPLEMENTATION OF A 360-STUDENT TRAINING MODEL. AT THE CORE OF THE PROGRAM ARE PROVEN STRATEGIES TO ENHANCE RECRUITMENT, RETENTION, AND PERSISTENCE IN STEM OF WOMEN AND UNDERREPRESENTED MINORITIES, INCLUDING THE COHORT MODEL, TEAM-TRAINING, AND A COMPREHENSIVE, INDIVIDUAL DEVELOPMENT PLAN-BASED MENTORING PROGRAM. THIS PROJECT WILL STRIVE TO EXTEND THE PROFESSIONAL DEVELOPMENT AND CAREER-CHOICE PROGRAM ELEMENTS TO ALL PARTICIPANTS, THEREBY BENEFITING A LARGE POPULATION OF FIU GRADUATE STUDENTS, ESPECIALLY THROUGH THE QISE CONCENTRATION TO BE DEVELOPED. THE PROJECT WILL FOSTER COLLABORATIVE EFFORTS WITH INDUSTRY, GOVERNMENT LABORATORY PARTNERS, AND OTHER ACADEMIC INSTITUTIONS, OFFERING TRAINEES A WIDE RANGE OF OPPORTUNITIES FOR INTERNSHIPS. THE TRAINING MODEL OUTCOMES WILL BE EVALUATED AND DISSEMINATED TO ENABLE ITS FACILE IMPLEMENTATION TO OTHER DEPARTMENTS AT FIU AND OTHER INSTITUTIONS, ESPECIALLY MINORITY SERVING INSTITUTIONS (MSIS). THE PROGRAM WILL ADVANCE TRANSFORMATIVE RESEARCH IN QISE WHILE TRAINING A DIVERSE POPULATION OF GRADUATE STUDENTS IN THIS AREA OF HIGH PRIORITY TO THE NATION. THE NSF RESEARCH TRAINEESHIP (NRT) PROGRAM IS DESIGNED TO ENCOURAGE THE DEVELOPMENT AND IMPLEMENTATION OF BOLD, NEW POTENTIALLY TRANSFORMATIVE MODELS FOR STEM GRADUATE EDUCATION TRAINING. THE PROGRAM IS DEDICATED TO EFFECTIVE TRAINING OF STEM GRADUATE STUDENTS IN HIGH PRIORITY INTERDISCIPLINARY OR CONVERGENT RESEARCH AREAS THROUGH COMPREHENSIVE TRAINEESHIP MODELS THAT ARE INNOVATIVE, EVIDENCE-BASED, AND ALIGNED WITH CHANGING WORKFORCE AND RESEARCH NEEDS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

TAMIU ADVANCED RESEARCH AND CURRICULUM (TAMIU ARC)

FLORIDA REGISTRY FOR AGING STUDIES

FIRST PRINCIPLES IN PRACTICE: TEACHING THE AMERICAN POLITICAL TRADITION

INTERVENTION FOR TEENS WITH ADHD AND SUBSTANCE USE

CAMELS AS BIOSURVEILLANCE SENTINELS: RISK AT THE HUMAN-CAMEL INTERFACE

STRENGTHENING INSTITUTIONS - HISPANIC SERVING INSTITUTIONS

MULTIMODAL RETINAL FUNCTIONAL IMAGING FOR DIABETIC RETINOPATHY

ADVANCING STUDENT PROGRESS THROUGH AN INNOVATIVE RESIDENCY EXPERIENCE (ASPIRE) PROJECT

GLYCOMICS LABORATORY FOR THE DEVELOPMENT OF OVARIAN CANCER BIOMARKERS

ANALYSIS OF E-SELECTIN LIGANDS OF HUMAN ACUTE LEUKEMIA CELLS AND THEIR BIOLOGY IN LEUKEMOGENESIS

INTERVENING WITH HIV+ ALCOHOL ABUSERS: INFLUENCE OF NEURO-BEHAVIORAL FACTORS

BIOSIGNATURES OF EXECUTIVE FUNCTION AND EMOTION REGULATION IN YOUNG CHILDREN WITH ADHD

UNDERSTANDING THE EFFECTS OF SUBSTANCE USE ON MALE COUPLES' RISK FOR HIV

EARLY CHILDHOOD BEHAVIORAL AND NEUROBIOLOGICAL PROFILES IN THE PREDICTION OF OBESITY: THE ROLE OF SELF-REGULATION AND THE CAREGIVING ENVIRONMENT

DEVELOPING HISPANIC-SERVING INSTITUTIONS PROGRAM

THIS AGREEMENT PROVIDES FUNDING IN THE AMOUNT OF $500,0000 SUPPORT FL INTERNATIONAL UNIVERSITY WATER QUALITY MONITORING WITHIN THE SOUTH FLORIDA AREA FOR THE FLORIDA KEYS NATIONAL MARINE SANCTUARY AND WILL DIRECTLY BENEFIT CITIZENS IN FLORIDA. THE OUTCOMES, OUTPUTS, AND DELIVERABLES INCLUDED WATER QUALITY MONITORING SAMPLING AND ANALYSIS TO COMPARE TRENDS AND POTENTIAL IMPACTS TO THE SANCTUARY'S WATER QUALITY. DELIVERABLES INCLUDES QUALITY ASSURANCE PROJECT PLAN, SEMI-ANNUAL REPORTING, PRESENTING AT CONFERENCES, ATTENDING BOARD MEETINGS, AND PROVIDE A PROJECT SUMMARY FOR EPA REVIEW AND DETERMINATION ON ADDRESSING THE SANCTUARY'S WATER QUALITY.

NEURAL-ENABLED PROSTHESIS WITH SENSORIMOTOR INTEGRATION

PARTNER: AN AI/ML COLLABORATIVE FOR SOUTHEAST FLORIDA COASTAL ENVIRONMENTAL DATA AND MODELING CENTER -THIS PROJECT IS AN EXPANDAI PARTNERSHIP BETWEEN THE FLORIDA INTERNATIONAL UNIVERSITY (FIU), NORTH CAROLINA STATE UNIVERSITY (NCSU), TEXAS A&M CORPUS CHRISTI (TAMU-CC), AND THE AI INSTITUTE FOR RESEARCH ON TRUSTWORTHY AI IN WEATHER, CLIMATE, AND COASTAL OCEANOGRAPHY (AI2ES). IN THIS PROJECT, A MINORITY-SERVING INSTITUTION LEADS A NEW COLLABORATION WITH TWO OTHER MSIS AND AN AI INSTITUTE FOCUSED ON SCALING UP ALREADY-ESTABLISHED RESEARCH AND EDUCATION PROGRAMS AT THEIR INSTITUTIONS AND TO PURSUE SHARED, COMPLEMENTARY GOALS AROUND DEVELOPING AI WITH USE FOR SOCIETY IN MIND AND FOR DEVELOPING THE NEXT GENERATION OF AI EDUCATION AND WORKFORCE TALENT. THE COLLABORATIVE RESEARCH FOCUSES ON THE DEVELOPMENT OF AI TO MANAGE THREATS OF FLOOD DAMAGE AND OTHER ENVIRONMENTAL STRESSES FACED BY AREAS WITH HIGH COASTAL POPULATION, WITH AN EMPHASIS ON ENVIRONMENTAL IMPACTS IN SOUTHEAST FLORIDA. THE PROJECT WILL ALSO BUILD COMMUNITY AROUND THIS NEW CENTER OF EXCELLENCE IN AI WHERE SUCH ACTIVITIES WERE NOT PREVIOUSLY WELL DEVELOPED. THIS PROJECT ESTABLISHES THE SOUTH FLORIDA COASTAL ENVIRONMENTAL DATA AND MODELING CENTER AT FLORIDA INTERNATIONAL UNIVERSITY (FIU), PROMOTING INTEGRATED RESEARCH AND EDUCATION EFFORTS TO DEVELOP ARTIFICIAL INTELLIGENCE AND MACHINE LEARNING TECHNIQUES FOR UNDERSTANDING AND PREDICTING THE KEY PROCESSES AFFECTING OCEAN, URBAN, AGRICULTURAL, AND NATURAL SYSTEMS, AND FOR STUDYING COASTAL ENVIRONMENTAL ISSUES IMPORTANT TO SOUTH FLORIDA. THIS REGION ENCOMPASSES ECOLOGICALLY SENSITIVE AND ECONOMICALLY IMPORTANT AREAS, SUCH AS BISCAYNE BAY, URBANIZED CORRIDORS, TRIBUTARY WATERSHEDS BORDERING THE BAY, AND THE SURFACE AND GROUNDWATER SYSTEMS IN REGIONAL WATERSHEDS. DUE TO HIGH PROPERTY VALUES, DENSE POPULATION, AND VULNERABLE LOW-LYING AREAS, THE REGION IS HIGHLY SUSCEPTIBLE TO FLOOD DAMAGE AND OTHER ENVIRONMENTAL STRESSES SUCH AS SEA-LEVEL RISE, URBAN FLOODING, WATER QUALITY MONITORING, AND HARMFUL ALGAE BLOOM DETECTION. THE PROJECT FOCUSES ON FOUR AREAS. FIRSTLY, THE CENTER MANAGES AND MAKES CURATED DATASETS AI-READY AND PUBLICLY AVAILABLE FOR TESTING AI/ML TECHNIQUES AND DEVELOPING SOLUTIONS. SECONDLY, THE RESEARCHERS COLLABORATE ON TRUSTWORTHY AI FOR UNDERSTANDING AND PREDICTING COASTAL ENVIRONMENTAL PHENOMENA, INCLUDING DEVELOPING PHYSICS-INFORMED AI MODELS, RELIABLE AI SYSTEMS, AND EXPLAINABLE AI METHODS. THIRDLY, THE RESEARCHERS APPLY AI/ML TO STUDY SOUTH FLORIDA COASTAL ENVIRONMENTAL PROBLEMS, SUCH AS SEA-LEVEL VARIABILITY, COMPOUND COASTAL FLOODING, AND HARMFUL ALGAE BLOOMS. LASTLY, FIU AND AI2ES PROVIDE EDUCATION, TRAINING, AND WORKFORCE DEVELOPMENT OPPORTUNITIES FOR DIVERSE UNDERGRADUATE AND GRADUATE STUDENTS AT FIU IN AI/ML AND ENVIRONMENTAL SCIENCE, INCLUDING DEVELOPING AN UNDERGRADUATE INTERDISCIPLINARY PROGRAM, STRENGTHENING PATHWAY PROGRAMS FOR STUDENTS FROM 2-YEAR COLLEGES, SHARING EDUCATION MATERIALS, AND FACILITATING RESEARCH EXCHANGE AND BUILDING ALLIANCES AMONG INSTITUTIONS VIA SITE VISITS, INTERNSHIP OPPORTUNITIES, AND CROSS-INSTITUTION WORKSHOPS AND SEMINARS. THE PROJECT IS PARTIALLY FUNDED BY NSF?S LOUIS STOKES ALLIANCES FOR MINORITY PARTICIPATION (LSAMP) PROGRAM WITHIN THE DIVISION OF EQUITY FOR EXCELLENCE IN STEM.? THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

BACTERIAL CELL KILLING BY TOPOISOMERASE I MEDIATED DNA LESION

PERSONALIZED PREVENTION FOR COUPLES - 1 SUMMARY / ABSTRACT 2 3 BETWEEN ONE TO TWO-THIRDS OF NEW HIV INFECTIONS AMONG MSM ARE ATTRIBUTABLE TO SEX WITH MAIN PARTNERS (I.E., 4 MALE COUPLES).1,2 48% OF HIV-POSITIVE MSM IN 5 US CITIES WHO WERE HIV TESTED IN CDC'S NHBS PROJECT WERE 5 UNAWARE OF THEIR STATUS,3 SUGGESTING THE POTENTIAL FOR HIGH LEVELS OF UNKNOWN SERO-DISCORDANCE AMONG MALE 6 COUPLES. RESEARCH HAS ALSO ILLUSTRATED THE ROLE THAT RELATIONSHIP DYNAMICS (E.G., HIV-SPECIFIC SOCIAL SUPPORT, 7 CONSTRUCTIVE COMMUNICATION, SEXUAL AGREEMENTS) HAVE IN SHAPING MALE COUPLES' RISK FOR HIV4-41; THIS HAS ALSO 8 BEEN SHOWN LONGITUDINALLY, STRONGLY SUGGESTING THAT PROMOTING POSITIVE RELATIONSHIP DYNAMICS IS A SIGNIFICANT 9 INTERVENTION POINT FOR REDUCING HIV TRANSMISSION AMONG MALE COUPLES.42-44 THERE IS ALSO EVIDENCE AT-RISK MALE 10 COUPLES CAN WORK TOGETHER TOWARDS SHARED HIV PREVENTION AND CARE-RELATED GOALS, INCLUDING PREP AND U=U/TASP 11 THAT RELY ON ADHERENCE AND RESULTANT VIRAL SUPPRESSION, LEADING TO INCREASED HEALTH AND REDUCED LIKELIHOOD OF 12 ONWARD HIV TRANSMISSION.45-55 INNOVATIVE AND TAILORED SOLUTIONS ARE NEEDED TO MEET THE HIV PREVENTION AND CARE 13 NEEDS OF AT-RISK MALE COUPLES. OUR SOLUTION IS TO LEVERAGE OUR STRONG FINDINGS FROM THE PRELIMINARY WORK WE 14 CONDUCTED IN THE US (R34 PILOT RCT & MIXED METHOD ACCEPTABILITY PROJECT)59-62 TO PROPOSE A HIGHLY NOVEL, 5-YEAR 15 PROJECT TO REVISE AND UPDATE AN EXISTING, EHEALTH COUPLES-BASED HIV/STI PREVENTION TOOLKIT INTERVENTION THAT 16 SHOWED PROMISE FOR REDUCING COUPLES' HIV RISK. THE INTERVENTION IS THEORETICALLY GROUNDED IN COUPLES 17 INTERDEPENDENCE THEORY FOR HEALTH BEHAVIOR CHANGE.63,64 WE WILL FIRST APPLY THE REMAINING STAGES OF THE ADAPT- 18 ITT MODEL65 WITH ELEMENTS OF HUMAN-CENTERED DESIGN66-69 TO INCORPORATE AT-RISK, SERO-CONCORDANT NEGATIVE AND 19 SERO-DISCORDANT MALE COUPLES' PREVENTION AND RELATIONSHIP NEEDS WHILE ALSO INCLUDING THE LATEST SCIENCE IN 20 HIV/STI PREVENTION. WE WILL THEN CONDUCT A 16-MONTH RCT WITH 300 AT-RISK MALE COUPLES USING A DELAYED, 21 EDUCATIONAL CONTROL CONDITION OF 8 MONTHS. OUR SPECIFIC AIMS ARE TO: 1) EXAMINE EFFICACY OF THE INTERVENTION ON 22 COUPLES' A) FORMATION AND ADHERENCE TO A RISK-REDUCTION PLAN AND AGREEMENT, B) RELATIONSHIP FUNCTIONING, C) SELF- 23 REPORTED AND BIOMARKER CONFIRMED INDICATORS OF RISK (SEXUAL BEHAVIOR AND STI), AND ENGAGEMENT IN HIV 24 PREVENTION (PREP ADHERENCE) AND CARE (ART ADHERENCE); 2) EVALUATE USE OF THE INTERVENTION OVER TIME BY USING 25 THREE DIFFERENT DATA SOURCES; 3) EXPLORE MODERATING AND MEDIATING EFFECTS ON COUPLES' OUTCOMES A-C. OUR PROPOSAL 26 HAS HIGH PUBLIC HEALTH SIGNIFICANCE GIVEN THE HIV DISPARITIES AND IMPORTANCE OF ATTENDING TO COUPLES' UNIQUE 27 RELATIONSHIP AND PREVENTION NEEDS. OUR INNOVATIVE, ACCESSIBLE, AND TAILORED INTERVENTION WILL FILL A GAP IN CURRENT 28 PREVENTION SERVICES BY OFFERING COUPLES A PERSONALIZED PROGRAM. WE BELIEVE RESULTS FROM THE FULLY POWERED RCT 29 WILL SHOW EFFICACY TOWARD IMPROVING SUSTAINED HIV PREVENTION OUTCOMES AMONG AT-RISK MALE COUPLES IN THE US. 30 THE SCIENTIFIC PREMISE AND RIGOR WILL FURTHER ALLOW US TO UNDERSTAND THE PROCESSES THAT COUPLES WORK TOGETHER 31 TO MANAGE HIV/STIS IN THEIR RELATIONSHIPS. OUR NEXT STEPS MAY INCLUDE CONDUCTING A TYPE 1 HYBRID TRIAL TO ASSESS 32 FOR EFFECTIVENESS AND EXPLORE BEST PRACTICES FOR FUTURE IMPLEMENTATION.70

MRI: DEVELOPMENT OF AN INSTRUMENT FOR STUDENT AND FACULTY RESEARCH ON MULTIMODAL ENVIRONMENTAL OBSERVATIONS

MECHANISMS OF DEFECTIVE MITOPHAGY AND CELLULAR SENESCENCE IN HIV ASSOCIATED COPD

HSI INSTITUTIONAL TRANSFORMATION PROJECT VOCES (VOICES FOR ORGANIZING CHANGE IN EDUCATIONAL SYSTEMS) -WITH SUPPORT FROM THE IMPROVING UNDERGRADUATE STEM EDUCATION: HISPANIC-SERVING INSTITUTIONS (HSI PROGRAM), THIS TRACK 3 PROJECT AIMS TO TRANSFORM UNIVERSITY PRACTICES BY INTEGRATING STUDENT-GENERATED STRATEGIES AND ACTIONS INTO FACULTY PROFESSIONAL DEVELOPMENT AND UNIVERSITY OPERATIONS, THUS, IMPROVING STUDENT LEARNING AND GRADUATION SUCCESS ACROSS ALL STEM DISCIPLINES. STUDENTS AT HSIS BRING A WEALTH OF EXPERIENCES AND COME THROUGH NUMEROUS EDUCATIONAL PATHWAYS. HOWEVER, THE RICHNESS OF THEIR EXPERIENCES IS GENERALLY AN UNDERUTILIZED RESOURCE AND NOT INTEGRATED INTO INSTITUTIONAL DECISIONS. THIS PROJECT WILL UTILIZE STUDENTS' EXPERIENCES TO SUSTAINABLY IMPROVE FLORIDA INTERNATIONAL UNIVERSITY'S (FIU) STUDENT SUCCESS THROUGH THE ESTABLISHMENT OF A STEM VOCEROS PROGRAM, CREATION OF FACULTY PROFESSIONAL DEVELOPMENT WITH STUDENTS AS PARTNERS, AND INSTITUTION PRACTICES AND POLICIES THAT INTEGRATE STUDENTS' PERSPECTIVES. THE EXPECTED OUTCOMES OF THIS WORK INCLUDE NEW STUDENT-LED EDUCATIONAL IMPROVEMENT MODELS THAT CAN BE ADAPTED AND IMPLEMENTED AT HSIS ACROSS THE NATION AND HAVE THE POTENTIAL TO TRANSFORM EDUCATIONAL SYSTEMS TO BETTER SERVE STUDENTS' NEEDS. THE SPECIFIC AIMS OF THE PROJECT INCLUDE CREATING A RESILIENT INSTITUTIONAL CHANGE MOVEMENT THAT ADVANCES STEM OPPORTUNITIES FOR FIU'S HISTORICALLY UNDERREPRESENTED STUDENT BODY. CENTRAL TO THE PROJECT IS THE ESTABLISHMENT OF THE STEM VOCEROS PROGRAM THAT WILL DEVELOP AND DEPLOY UNDERGRADUATES ACROSS ALL STEM DISCIPLINES TO IMPROVE INSTRUCTIONAL PRACTICE AND POLICIES SYSTEMICALLY AT THE INSTITUTION. STEM VOCEROS (LITERALLY, THE ONE THAT SPEAKS ON BEHALF OF OTHERS) WILL BE STUDENTS ENGAGED IN FACULTY PROFESSIONAL DEVELOPMENT, THROUGH MULTIPLE ORGANIZED WORKSHOPS AS WELL AS DEPLOYED IN STEM CLASSROOMS, CO-FACILITATING AND CO-DESIGNING EVIDENCE-BASED CURRICULUM THAT ENGAGES OUR HIGHLY DIVERSE STUDENT BODY AND LEADS TO IMPROVED FACULTY PRACTICE AND STUDENT OUTCOMES. VOCEROS WILL BE ENGAGED IN THE PROJECT?S RESEARCH ENTERPRISE TO EXAMINE INSTITUTION-LEVEL OUTCOMES AS WELL AS BRING THEIR STUDENT-FOCUSED PERSPECTIVE TO GUIDE THE RESEARCH. THE VOCEROS? INSTRUCTIONAL AND RESEARCH ROLES WILL INTENTIONALLY PREPARE THEM FOR STEM POLICY ENGAGEMENT, THEIR THIRD MAJOR ROLE. THEY WILL 1) CONDUCT STEM DEGREE PROGRAM REVIEWS ACROSS STEM DEPARTMENTS TO PROMOTE STUDENT NEEDS IN PROGRAM DESIGN, 2) ESTABLISH A STUDENT COMPASS, A YEARLY ACCOUNTABILITY REVIEW TO PROMOTE THE EDUCATIONAL OUTCOMES OF ALL STUDENTS, AND 3) ESTABLISH A STUDENT STEERING COMMITTEE TO GUIDE THE VOCES PROJECT. THIS MULTI-LAYERED DESIGN WILL INTEGRATE OUR DIVERSE STEM STUDENTS? VOICE AND EXPERIENCES THROUGHOUT THE INSTRUCTIONAL PRACTICES, RESEARCH MISSION AND INSTITUTIONAL POLICIES AND PRACTICES. FACULTY AND UNIVERSITY LEADERSHIP WILL BECOME RELIANT ON STUDENT VOICE AND CREATE THE OPPORTUNITY TO RE-ENVISION THE DECISION-MAKING NORMS AND THEREBY ESTABLISH SUSTAINED SYSTEMIC CHANGE AT FIU. VOCES WILL GENERATE NEW KNOWLEDGE ON THE EFFECTIVENESS OF STUDENT-LED INSTITUTIONAL CHANGE MODELS, AS WELL AS INCREASE OUR UNDERSTANDING OF ITS IMPACT ON STUDENTS' AGENCY, FACULTY PRACTICES, AND INSTITUTIONAL STRUCTURES AND PROCESSES AT AN HSI. THE STRATEGIES AND OUTCOMES WILL BE DISSEMINATED LOCALLY TO PARTNER INSTITUTIONS AS WELL AS NATIONALLY THROUGH ESTABLISHED NETWORKS AND PROFESSIONAL MEETINGS. THE HSI PROGRAM AIMS TO ENHANCE UNDERGRADUATE STEM EDUCATION AND BUILD CAPACITY AT HSIS. PROJECTS SUPPORTED BY THE HSI PROGRAM WILL ALSO GENERATE NEW KNOWLEDGE ON HOW TO ACHIEVE THESE AIMS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

CEREBRAL MICROVASCULAR SIGNALING AND NEUROVASCULAR COUPLING: AN INTEGRATED APPROACH TO INVESTIGATE VCID - SUMMARY NEURONAL ACTIVITY LEADS TO INCREASES IN LOCAL CEREBRAL BLOOD FLOW (CBF) TO ALLOW ADEQUATE SUPPLY OF O2 AND NUTRIENTS TO ACTIVE NEURONS. THIS PROCESS, TERMED NEUROVASCULAR COUPLING (NVC), IS ESSENTIAL FOR SURVIVAL AND ITS DISRUPTION IS ASSOCIATED WITH COGNITIVE DECLINE AND DEMENTIA. DESPITE SIGNIFICANT FINDINGS, WE ARE STILL FAR FROM REACHING A COMPREHENSIVE UNDERSTANDING OF NVC. THIS PROHIBITS US FROM A THOROUGH UNDERSTANDING OF NORMAL BRAIN FUNCTION AND FROM IDENTIFYING CRITICAL FAILURES IN DISEASE AND HINDERS INVESTIGATIONS INTO THE VASCULAR ORIGINS OF COGNITIVE IMPAIRMENT. THE OBJECTIVE OF THIS APPLICATION IS TO INVESTIGATE HOW K+-MEDIATED LOCAL CBF CONTROL EMERGES FROM THE INTEGRATION OF NEURONAL INPUTS AND AUTOREGULATORY FEEDBACK. THIS WILL BE ACCOMPLISHED BY PURSUING TWO SPECIFIC AIMS: IN AIM 1, MODELS OF ENDOTHELIAL AND SMOOTH MUSCLE CELLS WILL BE DEVELOPED AND EXAMINE K+-MEDIATED ELECTRICAL SIGNALING IN CAPILLARIES AND ARTERIOLES. WE PROPOSE THAT THE INWARD RECTIFYING K+ CHANNEL ACTS AS BISTABLE, “ON-OFF”, SWITCH TO HYPERPOLARIZE CELL MEMBRANES WHEN EXTRACELLULAR K+ INCREASES. MULTI- CELLULAR MODELS OF MICROVASCULAR NETWORKS WILL EXAMINE COMMUNICATION BETWEEN CAPILLARIES AND THEIR FEEDING ARTERIOLE, AND THE SIGNIFICANCE OF CAPILLARY-LEVEL NVC FOR LOCAL CBF CONTROL. WE PROPOSE THAT REGENERATIVE SIGNAL PROPAGATION ENABLES THIS COMMUNICATION AND WE WILL TEST THIS HYPOTHESIS USING MODELING AND AN EX-VIVO INTACT ARTERIOLE-CAPILLARY PREPARATION. IN AIM 2, SIMULATIONS IN A GEOMETRICALLY ACCURATE VASCULAR NETWORK WILL PREDICT MACROSCOPIC CHANGES IN BLOOD FLOW FOLLOWING FUNCTIONAL ACTIVATION. WE WILL INTEGRATE THEORY AND EXPERIMENTS TO ANALYZE CHANNELOPATHY-LIKE DEFECTS, IN ANIMAL MODELS OF CEREBRAL SMALL VESSEL AND ALZHEIMER'S DISEASE. WE WILL TEST THE HYPOTHESIS THAT IMPAIRED CAPILLARY-ARTERIOLE COMMUNICATION AND ALTERED MYOGENIC RESPONSE LEAD TO A NVC DEFICIT AND PROPOSE OPTIMAL STRATEGIES FOR RESTORING THIS DEFICIT. THE PROPOSED WORK WILL PROVIDE A PARADIGM FOR COMPREHENSIVE EXAMINATIONS OF CEREBRAL BLOOD FLOW CONTROL, FOR INTERPRETING ALTERED CELLULAR SIGNALING IN DISEASE AND FOR ELUCIDATING VASCULAR UNDERPINNINGS IN COGNITIVE IMPAIRMENT.

RULE OF LAW

BEYOND SABOR: A BORDER EMBEDDED HEALTH PROMOTION

ABERRANT MICRO-MANAGING OF THE AIRWAY EPITHELIAL TRANSCRIPTOME IN HIV-ASSOCIATED COPD - PROJECT SUMMARY THE LONG-TERM GOAL OF THIS PROPOSAL IS TO IDENTIFY THE PATHOPHYSIOLOGY UNDERLYING HIV ASSOCIATED COPD. PEOPLE LIVING WITH HIV (PLWH) SHOW INCREASED INCIDENCE OF COPD EVEN WHEN COMPENSATED FOR SMOKING STATUS. MICRORNAS MANAGE THE CELLULAR TRANSCRIPTOME AND PLAY IMPORTANT ROLES IN HEALTH AND DISEASE. WE HAVE SHOWN THAT HIV TAT AND TRANSFORMING GROWTH FACTOR-BETA (TGF-SS) SIGNALING DYSREGULATE THE AIRWAY MICRORNAOME. DYSREGULATION OF THE MICRORNAOME CAN EFFECT MULTIPLE SIGNALING PATHWAYS AND THIS CAN AFFECT CELLULAR HOMEOSTASIS. COPD IS A MULTIFACTORIAL PATHOLOGY AND INVOLVES DYSREGULATION OF DIVERSE SIGNALING PATHWAYS THAT CONVERGE TOWARDS AIRWAY MITOCHONDRIAL DISFUNCTION, CIRCADIAN DYSREGULATION, REMODELING, INFLAMMATION, ETC. TGF- SS SIGNALING IS INDUCED BY BOTH HIV TAT AND CIGARETTE SMOKE AND THIS IS SIGNIFICANT SINCE A SIGNIFICANT PROPORTION OF PLWH ARE ADDICTED TO NICOTINE AND SMOKE TOBACCO/CIGARETTES, POSSIBLY EXACERBATING THEIR PROGRESSION TO COPD. HENCE, TAT AND TGF-SS-INDUCED ABERRANT MICRORNAOME AND ITS EFFECTS ON THE AIRWAY TRANSCRIPTOME CAN SERVE AS AN INITIATING EVENTS WITH DOWNSTREAM CONSEQUENCES ON CRITICAL SIGNALING NODES AND PATHWAYS. IDENTIFYING THESE PATHWAYS AND THESE CRITICAL SIGNALING NODES CAN HELP TAILOR INTERVENTIONS TO IMPROVE LONG-TERM PULMONARY OUTCOMES IN PLWH. LUNGS ARE IMPORTANT HIV RESERVOIRS AND WE, AND OTHERS HAVE SHOWN THAT AIRWAY EPITHELIAL CELLS EXPRESS CANONICAL HIV RECEPTORS AND CAN BE INFECTED WITH HIV. A RECENT STUDY SHOWS THAT THE BULK OF HIV RESERVOIRS ARE TRANSCRIPTIONALLY ACTIVE EVEN WITH SUPPRESSIVE CART. HENCE, SILENCING HIV TRANSCRIPTION CAN DECREASE HIV PROTEINS LIKE TAT IN THE AIRWAY. GENE EDITING USING CRISPR/CAS9 HAS TREMENDOUS POTENTIAL IN ELIMINATING HIV RESERVOIRS AND REPORTS HAVE SHOWN EXCISION OF HIV FROM INFECTED CELLS. HOWEVER, CRISPR BASED HIV EXCISION IS VULNERABLE TO VIRAL ESCAPE AS WELL AS OFF-TARGET EFFECTS. CYCLIN T1, A COMPONENT OF P-TEFB, (HETERODIMER OF CYCLINT1 AND CDK9) IS BOUND BY HIV TAT AND PLAYS A PIVOTAL ROLE HIV TRANSCRIPTION AND ITS INHIBITION ABOLISHES HIV TRANSCRIPTION. HENCE CRISPR MEDIATED CYCLINT1 INACTIVATION WILL COMPLETELY BLOCK HIV TRANSCRIPTION, LOCKING THE HIV PROVIRAL DNA IN AN INACTIVE FORM. WE WILL USE OUR PATENTED POL II HIV LTR-DROSOPHILA HSP70 FUSION MONOPROMOTER TO CO-EXPRESS CYCLINT1 GRNA AND CAS9 (AND EFFECT CYCLINT1 INACTIVATION) ONLY IN HIV INFECTED CELLS. EXPRESSION IS SELF-LIMITING AS OUR FUSION PROMOTER ALSO REQUIRES CYCLINT1 THEREBY MINIMIZING OFF- TARGET EFFECTS. AIM 1 WILL DETERMINE THE MECHANISM BY WHICH HIV TAT AND TGF-SS DYSREGULATE THE AIRWAY MICRORNAOME AND ITS EFFECTS ON THE TRANSCRIPTOME TO IDENTIFY SIGNALING PATHWAYS INVOLVED IN HIV ASSOCIATED COPD. AIM 2 WILL USE AN INDUCIBLE CRISPR SYSTE TO INACTIVATE CYCLINT1 ONLY IN HIV INFECTED CELLS AND LOCK THE PROVIRAL DNA IN A TRANSCRIPTIONALLY INACTIVE STATE. UNDERSTANDING THE SIGNALING PATHWAYS THAT PROMOTE HIV- ASSOCIATED COPD AND SILENCING HIV TRANSCRIPTION IN RESERVOIRS WILL PREVENT LUNG FUNCTION DECLINE AND DEVELOPMENT OF COPD IN PLWH.

UNKNOWN TITLE

INTERVENING WITH HAITIAN HIV+ ALCOHOL ABUSERS: AN ENVIRONMENTAL PSYCHOSOCIAL FRAM

GLOBAL WATER FOR SUSTAINABILITY (GLOWS)

PRESYNAPTIC MECHANISMS OF LEAD NEUROTOXICITY

EFFICACY OF AN MHEALTH + E-NAVIGATOR STEPPED CARE INTERVENTION FOR ART ADHERENCE AMONG LATINO MSM - PROJECT SUMMARY APPROXIMATELY 40% OF LATINO MSM WITH HIV DO NOT ACHIEVE VIRAL SUPPRESSION—AN ESTIMATE THAT HAS LIKELY WORSENED DUE TO COVID-19 PANDEMIC STRESSORS SUCH AS UNEMPLOYMENT, LOSS OF HEALTH INSURANCE, HOMELESSNESS, AND EXACERBATED MENTAL HEALTH AND SUBSTANCE USE DISORDERS CAUSED BY THE COVID-19 PANDEMIC. ANTIRETROVIRAL THERAPY (ART) ADHERENCE IS ASSOCIATED WITH DECREASED VIRAL LOAD, INCREASED CD4 COUNTS, FEWER HOSPITAL DAYS, SLOWER DISEASE PROGRESSION, AND LONGER SURVIVAL. ADHERENCE ALSO HELPS PREVENT DRUG RESISTANCE AND REDUCES HIV TRANSMISSION RISK. THE PRIMARY OBJECTIVE OF THIS STUDY IS TO EVALUATE THE EFFICACY OF STEPPED CARE STRATEGIES TO IMPROVE ART ADHERENCE AMONG ADULT LATINO MSM WITH HIV USING A SEQUENTIAL, MULTIPLE ASSIGNMENT, RANDOMIZED TRIAL (SMART). THE TRIAL WILL COMPARE A STEPPED CARE STRATEGY OF DELIVERING TXTXT FIRST AND STEPPING UP TO REMOTE PATIENT NAVIGATION FOR NON-RESPONDERS VS. A STEPPED CARE STRATEGY OF DELIVERING TXTXT + E-NAVIGATION FIRST AND STEPPING UP TO EMA-SUPPORTED E-NAVIGATION FOR NON- RESPONDERS. BOTH, TXTXT (“TREATMENT TEXT”) AND THE FOUNDATIONS OF THE E-NAVIGATION INTERVENTIONS ARE CDC EVIDENCE-BASED INTERVENTIONS (EBI). WE PROPOSE TO USE A SMART DESIGN WHICH EXPLICITLY ALLOWS BUILDING, TESTING, AND OPTIMIZING STEPPED CARE STRATEGIES WITHOUT COMPROMISING RIGOR OR RANDOMIZATION. WE PROPOSE THREE SPECIFIC AIMS: AIM 1. COMPARE THE IMMEDIATE (6-MONTH) AND SUSTAINED (9- AND 12-MONTH) EFFICACY OF TWO STATIC (NON-STEPPED) TREATMENT REGIMENS (TXTXT ALONE VS. TXTXT + E-NAVIGATION) ON ART ADHERENCE AND VIRAL SUPPRESSION AMONG LATINO MSM WITH HIV. AIM 2. COMPARE THE IMMEDIATE (6-MONTH) AND SUSTAINED (9- AND 12-MONTH) EFFICACY OF TWO STEPPED CARE STRATEGIES (TXTXT WITH ADDED E-NAVIGATION FOR NON-RESPONDERS VS. TXTXT + E-NAVIGATION WITH ADDED EMA SUPPORT FOR NON-RESPONDERS) ON ART ADHERENCE AND VIRAL SUPPRESSION AMONG LATINO MSM WITH HIV. AIM 3. IDENTIFY BASELINE AND TIME-VARYING MODERATORS ON THE ASSOCIATION BETWEEN STEPPED CARE STRATEGY AND ART ADHERENCE AND VIRAL SUPPRESSION AMONG LATINO MSM WITH HIV. THE PROPOSED STUDY IS INNOVATIVE BY CULTURALLY ADAPTING AND COMBINING TWO EBIS, USING A STEPPED CARE APPROACH, REMOTE PATIENT NAVIGATORS, ADAPTIVE EMA COMPONENTS, AND A SMART DESIGN. THE PROPOSED STUDY IS SIGNIFICANT BECAUSE IT PROVIDES DATA ON THE EFFICACY OF TWO SCALABLE EBIS IN ONE EFFICIENT DESIGN AND PROVIDES DATA ON ENHANCED TREATMENT OPTIONS FOR NON-RESPONDERS. THE STUDY IS ALSO SIGNIFICANT BECAUSE IT TARGETS AN NIH HEALTH DISPARITY POPULATION (LATINO MSM) AND ADDRESSES MULTIPLE DOMAINS AND LEVELS OF INFLUENCE ON HEALTH AND HEALTH DISPARITIES. IT ALSO TARGETS PEOPLE LIVING IN AN ENDING THE HIV EPIDEMIC GEOGRAPHIC FOCUS AREA WITH THE HIGHEST HIV DIAGNOSIS RATE IN THE NATION (SOUTH FLORIDA), THEREBY SUPPORTING THE OBJECTIVES OF REDUCING HIV DISPARITIES IN POPULATIONS AT HIGH RISK AND LIVING IN THE SOUTHERN US.

AWARD TYPE: PROJECT GRANT; ACTIVITIES TO BE PERFORMED: PROVIDE HIGH QUALITY SUPPORT AND TECHNICAL ASSISTANCE WITH PANDEMIC RELIEF PROGRAMS AND RECOVERY SERVICES TO SMALL BUSINESSES.; DELIVERABLES: GRANTEES WILL PROVIDE REPORTS ON ACTIVITIES AND PROGRESS TOWARD STATED GOALS TO SBA ON A QUARTERLY BASIS.; EXPECTED OUTCOMES: INCREASE AWARENESS OF AND PARTICIPATION IN PROGRAMS OF THE U.S SMALL BUSINESS ADMINISTRATION AND OTHER GOVERNMENT AGENCIES.; INTENDED BENEFICIARIES: SMALL BUSINESSES AND ENTREPRENEURS THAT FALL INTO A HISTORICALLY UNDERSERVED CATEGORY, INCLUDING MINORITY ENTREPRENEURS (BLACK, INDIGENOUS, AND PEOPLE OF COLOR), ENTREPRENEURS WITH DISABILITIES, LGBTQ ENTREPRENEURS, RURAL ENTREPRENEURS; VETERANS AND MILITARY ENTREPRENEURS (INCLUDING SPOUSES), WOMEN ENTREPRENEURS, INNOVATIVE STARTUPS, MICRO BUSINESSES, AND SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESSES; SUBRECIPIENT ACTIVITIES: GRANTEES (HUBS) AND THEIR CONTRACTORS (SPOKES) WILL PROVIDE HIGH QUALITY SUPPORT AND TECHNICAL ASSISTANCE WITH PANDEMIC RELIEF PROGRAMS AND RECOVERY SERVICES TO SMALL BUSINESSES. THIS SUPPORT TAKES THE FORM OF 1:1 COUNSELING AND GROUP TRAININGS.

CENTER FOR AGILE AND INTELLIGENT POWER SYSTEMS (CAIPS): CYBERSECURITY RESEARCH, DEVELOPMENT, AND WORKFORCE TRAINING THE GOAL OF THIS PROPOSAL IS TO ESTABLISH A REGIONAL CYBERSECURITY CENTER LEVERAGING PARTNERSHIPS BETWEEN REGIONAL UNIVERSITIES AND ENERGY UTILITIES, NATIONAL LABORATORIES, AND SYSTEM VENDORS TO PERFORM APPLIED RESEARCH AND DEVELOPMENT IN ADDITION TO CURRICULUM AND WORKFORCE DEVELOPMENT.

PROMOTING POSTBACCALAUREATE OPPORTUNITIES FOR HISPANIC AMERICANS (PPOHA)

INTERNET TREATMENT FOR BEHAVIOR PROBLEMS IN PRESCHOOLERS WITH DEVELOPMENTAL DELAY

PHYSICIAN MIGRATION AND ITS IMPLICATIONS FOR PUERTO RICO'S HEALTH CARE SYSTEM

PROMOTING POSTBACCALAUREATE OPPORTUNITIES FOR HISPANIC AMERICANS (PPOHA)

SALEM UNIVERSITY UPWARD BOUND WILL SERVE AN AREA THAT IS RURAL, THE TARGET AREA'S INCOME LEVEL IS LOW, WITH A LARGE AMOUNT OF FIRST GENERATION, LOW-INCOME STUDENTS WITH ACADEMIC NEED

FUNGAL METABOLITES BLOCK MALARIA TRANSMISSION

MECHANISM OF GENE ENVIRONMENT INTERACTIONS IN ALZHEIMER'S DISEASE

DEVELOPING AND TESTING HEALTH WARNING LABELS ON THE ENDS DEVICE - DEVELOPING AND TESTING HEALTH WARNINGS FOR ENDS PROJECT SUMMARY THE USE OF ELECTRONIC NICOTINE DELIVERY SYSTEMS (ENDS OR E-CIGARETTES) HAS REACHED EPIDEMIC LEVELS AMONG YOUNG PEOPLE IN THE UNITED STATES (US). ENDS EMIT TOXIC SUBSTANCES, INCLUDING NICOTINE THAT IRREVERSIBLY AFFECTS YOUTH’S DEVELOPING BRAIN LEADING TO DEPENDENCE AND INCREASED RISK OF CIGARETTE SMOKING INITIATION, YET MISPERCEPTIONS ABOUT THEIR SAFETY ARE WIDESPREAD. THEREFORE, HEALTH COMMUNICATION OF ENDS-RELATED RISKS THROUGH HEALTH WARNING LABELS (HWLS) HAS BEEN CONSIDERED AS A PRIORITY BY LEADING HEALTH AND REGULATORY BODIES IN THE US TO REDUCE ENDS USE AMONG YOUNG PEOPLE. WE HAVE DEVELOPED AND PILOT-TESTED A CLINICAL LAB MODEL TO EXAMINE THE POTENTIAL EFFECTS OF PICTORIAL HWLS ON YOUNG (21-29 YRS) ENDS USERS’ EXPERIENCES. IN THIS PROPOSAL, WE WILL USE THIS MODEL COUPLED WITH A SYSTEMATIC DEVELOPMENT OF ENDS PICTORIAL HWLS TO TEST THEIR EFFECT WHEN THEY ARE PLACED ON THE DEVICE ON A VARIETY OF SUBJECTIVE (E.G. SATISFACTION, HARM PERCEPTION, NICOTINE DEPENDENCE, INTENTION TO QUIT) AND OBJECTIVE OUTCOMES (E.G. PLASMA NICOTINE, PUFF TOPOGRAPHY). THIS WILL BE DONE IN THREE STAGES. FIRST, WE WILL REVIEW THE LITERATURE AND DEVELOP CANDIDATE MESSAGES AND THEIR ASSOCIATED PICTURES FOR THE HWLS (N=45). THIS INITIAL SET OF HWLS WILL THEN BE REVISED AND RANKED THROUGH A DELPHI STUDY AMONG TOBACCO CONTROL, REGULATION, AND HEALTH COMMUNICATION EXPERTS. SECOND, WE WILL CONDUCT FOCUS GROUPS WITH YOUNG ENDS (21-29 YRS) USERS TO ADAPT THE CANDIDATE HWLS TO OUR TARGET POPULATION AND DEVICE ITSELF. THIRD, WE WILL TEST HWLS ON THE ENDS DEVICE IN A CLINICAL LAB CROSS-OVER STUDY, WHERE EACH SUBJECT USES ENDS IN 2 SESSIONS; 1) THEIR PREFERRED PRODUCT WITHOUT HWL (CONTROL), AND 2) THEIR PREFERRED PRODUCT WITH PICTORIAL HWL ON THE ENDS DEVICE. THIS DESIGN WILL ALLOW US TO TEST OUR MAIN HYPOTHESIS; COMPARED TO CONTROL, USING ENDS WITH THE HWLS IS ASSOCIATED WITH DECREASED SATISFACTION, DEPENDENCE SUPPRESSION, AND PUFFING BEHAVIOR, BUT INCREASED KNOWLEDGE ABOUT HARM AND INTENTION TO QUIT. THIS PROJECT WILL GUIDE POLICYMAKERS INTO THE APPLICATION OF EFFECTIVE HWLS FOR ENDS AND WILL DEVELOP WARNING MESSAGES AND PICTORIALS THAT NATIONAL AND STATE STAKEHOLDERS CAN USE THROUGH DIFFERENT MODALITIES IN COUNTER-MARKETING CAMPAIGNS TO PROTECT YOUNG PEOPLE AND DISCOURAGE HARMFUL ENDS USE.

WOMEN-CENTERED HIV CARE PRACTICES THAT FACILITATE HIV CARE RETENTION AND VIRAL SUPPRESSION IN THE PRESENCE OF ADVERSE SOCIOCULTURAL FACTORS

HIV AND HIV/HCV-INFECTION, DISEASE PROGRESSION, OXIDATIVE STRESS AND ANTIOXIDANTS

SCI/IRNC: WHREN (WESTERN HEMISPHERE RESEARCH AND EDUCATION NETWORKS): INCREASING THE RATE OF DISCOVERY AND ENHANCING EDUCATION ACROSS THE AMERICAS

ADVANCED NURSE EDUCATION-SEXUAL NURSE ASSAULT EXAMINER PROGRAM

FUNDS TO BE USED FOR SUPPORTING RELATED TRINITY INTERNATIONAL UNIVERSITY ENTITIES AFFECTED BY COVID-19.

LTER: DRIVERS OF ABRUPT CHANGE IN THE FLORIDA COASTAL EVERGLADES

UNIVERSITY-ASSISTED COMMUNITY SCHOOL NETWORK (U-ACSN)

ANALYSIS OF GLYCOMIC REGULATORS IN MELANOMA PROGRESSION

CHILDREN'S RESPONSES TO SIBLING DEATH IN NICU/PICU IN 3 RACIAL/ETHNIC GROUPS

GAINING EARLY AWARENESS AND READINESS FOR UNDERGRADUATE PROGRAMS (GEAR-UP) - GEAR-UP

SCHOLARSHIPS FOR DISADVANTAGED STUDENTS

ALCOHOL & ANTIRETROVIRALS IN HIV INFECTION, OXIDATIVE STRESS AND LIVER DISEASE

THIS ACTION PROVIDES ADDITIONAL FUNDING IN THE AMOUNT OF $450,000 TO FLORIDA INTERNATIONAL UNIVERSITY TO CONTINUE TO SUPPORT THE FLORIDA KEYS NATIONA

PIRE: A GLOBAL LIVING LABORATORY FOR CYBERINFRASTRUCTURE APPLICATION ENABLEMENT

CARES ACT: HIGHER EDUCATION EMERGENCY RELIEF FUND/INSTITUTION

PROVIDE SPECIALIZED SUPPORT SERVICES TO THE OFFICE OF EVERGLADES RESTORATION INITIATIVES

ADVANCED RESEARCH COOPERATION IN ENVIRONMENTAL HEALTH RESEARCH

TARGETING INFLAMMASOME WITH STABLE ENDOCANNABINOID LIGAND AMG315. CRISPR/CAS9 AND NANOTECHNOLOGY STUDY IN THE CONTEXT OF HIV AND CANNABINOID