Haft Inc

ADVANCED HYDROGEN TURBINE FOR FUTUREGEN

MODIFICATION 023 - NCE, FUNDING, REVISE PO

COAL GAS FUELED SOFC HYBRID POWER SYSTEMS WITH CO2 SEPARATION

NAVISTAR SUPERTRUCK II DEVELOPMENT AND DEMONSTRATION

TAS::89 0211::TAS RECOVERY NEW AWARD ENTITLED, "RECOVERY ACT:SLIPSTREAM DEVELOPMENT AND TESTING OF SIEMENS POSTCAP CAPTURE AND SEPARATION TECHNOLOGY

DEVELOPMENT OF SMALL SCALE, LOW COST SOLID OXIDE FUEL CELL POWER SYSTEM UNDER THE SOLID-STATE ENERGY CONSERVA- TION ALLIANCE(SECA)

THE DEVELOPMENT OF DIRECTION SELECTIVITY IN VISUAL CORTEX

PLUG & PLAY SOLAR PV FOR AMERICAN HOMES

NEURONAL INTRACELLULAR SIGNALING UNDERLYING SYNAPTIC, CIRCUIT AND BEHAVIORAL PLASTICITY

SECA COAL BASED SYSTEMS - SIEMENS ENERGY

NOVEL APPROACHES TO BREAST CANCER PREVENTION AND INHIBITION OF METASTASES

THE SGSS PROJECT (NASA/GSFC CODE 458) IS TASKED WITH DEVELOPING, IMPLEMENTING, AND SUPPORTING THE TRANSITION TO OPERATIONS OF A MODERNIZED GROUND SEG

MECHANISMS OF RAS SIGNALING IN SINGLE SYNAPSES

THE PURPOSE OF THE LUANGWA AND LIVELIHOOD AND CONSERVATION ACTIVITY IS TO ENHANCE THE RESILIENCE AND HEALTH OF NATURAL RESOURCE-DEPENDENT ECOLOGICAL AND HUMAN COMMUNITIES IN THE LUANGWA VALLEY (LV) OF ZAMBIA THROUGH STRONG PUBLIC-PRIVATE-COMMUNITY PARTNERSHIPS AND ENTERPRISE, IN ORDER TO MAINTAIN AND IMPROVE THE STATE OF NATURAL RESOURCES, SUCH AS THE POPULATION SIZE OF KEY SPECIES, OR THE AREA OF LAND UNDER EFFECTIVE MANAGEMENT. LOCAL COMMUNITY MEMBERS WILL, IN TARGET AREAS, BENEFIT FROM IMPROVED NUTRITION AND ACCESS TO SAFE WATER, EDUCATIONAL SERVICES AS WELL AS DIVERSIFIED AND SUSTAINABLE CONSERVATION-COMPATIBLE LIVELIHOODS.

OPTIMIZATION OF GENETICALLY ENCODED VOLTAGE AND NEUROTRANSMITTER INDICATORS FOR MULTIWAVELENGTH IN VIVO ANALYSIS OF BRAIN CIRCUITS - THE BRAIN IS REMARKABLY DYNAMIC, ADAPTIVE, AND FLEXIBLE IN RESPONSE TO ENVIRONMENTAL CHANGES. THESE CAPACITIES ARE ENABLED BY DIVERSE CELL TYPES WHICH COMMUNICATE WITH AN ARRAY OF CHEMICAL NEUROTRANSMITTERS (NTS) OR NEUROMODULATORS (NMS) AND RECEPTORS. NEUROCHEMICAL INPUTS HAVE A WIDE-RANGING AND DRAMATIC INFLUENCE ON NEURONAL ACTIVITY AND CIRCUIT DYNAMICS. TO UNDERSTAND THE LOGIC BY WHICH MULTIPLE CONVERGENT INPUTS SHAPE NEURONAL ACTIVITY, IT IS ESSENTIAL TO RECORD THE TIMING AND LOCATION OF NT AND NM RELEASE AND THE DYNAMIC CHANGES IN MEMBRANE VOLTAGE THAT RESULT. OUR TEAM HAS DEVELOPED GENETICALLY ENCODED INDICATORS, AS WELL AS HIGH-SPEED AND RESOLUTION MICROSCOPY, TO ALLOW SIMULTANEOUS OPTICAL MEASUREMENT OF VARIOUS NT/NM RELEASE AND DIFFUSION AND POST-SYNAPTIC ACTIVITY IN VIVO WITH CELL-TYPE AND CIRCUIT SPECIFICITY. BROAD APPLICATIONS OF THESE TECHNOLOGIES HAVE STARTED TO REVEAL HOW NEUROMODULATORS COLLECTIVELY MANIPULATE BRAIN-WIDE STATES. DESPITE THESE SUCCESSES, SIGNIFICANT HEADROOM EXISTS TO OPTIMIZE THESE INDICATORS TO ENABLE SENSITIVE IMAGING IN SMALL STRUCTURES, HIGHER THROUGHPUT, AND MEASUREMENTS IN SPARSELY-INNERVATED BRAIN AREAS. MOREOVER, EXISTING NT AND VOLTAGE INDICATORS ARE NEARLY ALL GREEN IN COLOR, AND OPTIMIZATION OF OTHER COLORS IS NEEDED TO ENABLE MULTIPLEXING, ALONG WITH HARDWARE TO PERFORM SUCH RECORDINGS AND ALGORITHMS TO PROCESS THEM. FINALLY, THESE NEW TOOLS MUST BE RIGOROUSLY AND SYSTEMATICALLY BENCHMARKED IN VIVO TO ALLOW THE LARGE COMMUNITY OF USERS TO BETTER DESIGN AND INTERPRET MEASUREMENTS IN BEHAVIORAL EXPERIMENTS. WITH AVAILABLE TECHNOLOGY, WE HAVE YET TO ADDRESS THE DIVERSITY OF CHEMICAL NEUROTRANSMISSION AT SCALES CRUCIAL TO UNDERSTANDING BRAIN CIRCUIT FUNCTION. THEREFORE THE OVERARCHING GOAL OF THIS UM1 PROPOSAL IS TO ESTABLISH A MULTIDISCIPLINARY, MULTI-INVESTIGATOR, AND MULTI-INSTITUTION PROGRAM FOCUSING ON DEVELOPING TOOLS FOR MEASURING MOLECULAR INPUTS TO NEURONS AND RESULTING ACTIVITY, INCLUDING: ENGINEERING OPTIMIZED AND MULTI-COLOR FP-BASED INDICATORS FOR NT/NM AND VOLTAGE (AIM 1); DETAILED CHARACTERIZATION AND BENCHMARKING OF INDICATORS IN VIVO (AIM 2); DISSEMINATING VETTED, BEST-OF-CLASS REAGENTS AND RELATED TESTING DATA (AIM 3). OUR EFFORT WILL PROVIDE THE FOUNDATION FOR UNRAVELING THE LOGIC OF INPUT-OUTPUT TRANSFORMATION IN DEFINED CELL TYPES IN VIVO, WHICH UNDERLIE INFORMATION PROCESSING, BRAIN STATES, CIRCUIT PLASTICITY, AND (ULTIMATELY) BEHAVIOR.

MASS CUSTOMIZATION OF PREFABRICATED PANEL BLOCKS FOR DEEP WALL INSULATION RETROFITS

CERAMIC MATRIX COMPOSITE ADVANCED TRANSITION FOR 65% COMBINED CYCLE

DONOR TO DONOR GRANT AGREEMENT /CLIMATE FINANCE READINESS

THE PURPOSE OF THIS AGREEMENT IS TO FUND RESEARCH SUPPORTING DSO IN THE AMOUNT OF 350,000 ON CONTRACT HR0011-17-2-0015.

DECIPHERING BIOCHEMICAL NETWORKS IN SINGLE DENDRITIC SPINES

MEDIUM-DUTY URBAN RANGE EXTENDED CONNECTED POWERTRAIN (MURECP)

TAS::89 0318::TAS OE INDUSTRIAL BREAKOUT, NEW AWARD

HYDROAIR POWER TAKE OFF SYSTEM

MADERA AVENUE INTERTIE

THE SHAFTER-WASCO IRRIGATION DISTRICT (SWID) IN KERN COUNTY, CALIFORNIA WILL CONSTRUCT A 112-ACRE GROUNDWATER RECHARGE FACILITY THAT WILL STORE UNCONTROLLED FLOOD WATER FROM THE KERN RIVER AND THE CENTRAL VALLEY PROJECT FOR LATER BENEFICIAL USE TO OFFSET WATER SHORTAGES DURING DRY YEARS. SWID UTILIZES CONJUNCTIVE USE MEASURES TO ENSURE LONG-TERM SUSTAINABILITY FOR WATER USERS. THIS PROJECT WILL DIRECTLY HELP WITH SWIDS DROUGHT RESILIENCY AND HELP INCREASE ACCESS TO GROUNDWATER SUPPLIES BY PROVIDING AN ADDITIONAL 7,726-ACRE FEET PER YEAR, REPRESENTING A 18.7% INCREASE IN THE TOTAL ANNUAL AVERAGE WATER SUPPLY. THE PROJECT IS SUPPORTED BY THE POSO CREEK INTEGRATED REGIONAL WATER MANAGEMENT (IRWM) REGION DROUGHT CONTINGENCY PLAN THAT WAS DEVELOPED WITH ASSISTANCE FROM A WATERSMART (SUSTAIN AND MANAGE AMERICA S RESOURCES FOR TOMORROW) DROUGHT CONTINGENCY PLANNING GRANT.

FUNCTIONAL ORGANIZATION OF VISUAL CORTEX

BUILDING EQUITABLE PARTNERSHIPS FOR TECHNOLOGY TRANSFER OF IN-DEMAND PUBLICLY BRED SEED TECHNOLOGIES IN SUB-SAHARAN AFRICA

NORTH LUANGWA ECOSYSTEM PROJECT GLOBAL DEVELOPMENT ALLIANCE

BIO-MEDICAL AND SOCIO-ECONOMIC PRECURSORS OF COGNITIVE DECLINE IN SHARE

ADVANCED CARBON DIOXIDE COMPRESSION WITH SUPERSONIC TECHNOLOGY

ZERO EMISSIONS COAL SYNGAS-OXYGEN TURBO MACHINERY

DEVICE ARCHITECTURE SIMPLIFICATION OF LASER PATTERNING IN HIGH-VOLUME CRYSTALLINE SILICON SOLAR CELL FABRICATION USING INTENSIVE COMPUTATION FOR DESI

CATALYTIC COMBUSTOR FOR FUEL-FLEXIBLE TURBINE

ZAMBIAN PREVENTION OF INTERNATIONAL TRADE IN WILDLIFE (ZAPIT)

SUNDIAL - AN INTEGRATED SHINES SYSTEM TO ENABLE HIGH-PENETRATION FEEDER-LEVEL PV

MULTIPLEX INTERROGATION OF NEUROMODULATORY SIGNALING IN BEHAVING ANIMALS WITH ENHANCED DEPTH AND RESOLUTION - PROJECT SUMMARY THE DYNAMIC ADAPTABILITY OF THE MAMMALIAN BRAIN TO ENVIRONMENTAL CHANGES IS REMARKABLE, AS IT IS THE COMPLEXITY OF THE NETWORKS OF NEURONS UNDERLYING THE OPERATIONS THAT ALLOW FOR SUCH ADAPTATIONS. ALTHOUGH WE HAVE SOME UNDERSTANDING OF THE ANATOMICAL AND FUNCTIONAL BASIS OF THIS, WE ARE STILL LACKING A DETAILED PICTURE OF HOW THE MODULATION OF NEURONAL ACTIVITY WORKS. WHAT IS THE TIMING AND LOCATIONS OF THESE NEUROMODULATOR RELEASE AND RELATIONSHIP WITH EXCITATORY/INHIBITORY CIRCUITS? HOW DOES THE NEUROMODULATORS CIRCUITRY ACCOMPLISH THE REGULATION OF FIRING AND SYNAPTIC PROPERTIES OF TARGETED NEURONS? FILLING THESE GAPS IN KNOWLEDGE WOULD ADVANCE OUR UNDERSTANDING OF ALL ASPECTS OF NEUROMODULATOR BIOLOGY AND ALLOW DISCOVERY OF NEW THERAPEUTIC STRATEGIES. TO HELP CLOSE THIS GAP, WE HAVE USED CREATIVE APPROACHES TO THE DEVELOPMENT OF GENETICALLY ENCODED TO DIRECTLY REPORT BEHAVIORALLY TRIGGERED AND MODULATED NEUROMODULATOR RELEASE INCLUDING SEROTONIN (5-HT), DOPAMINE (DA) AND NOREPINEPHRINE (NE). WE HAVE DISSEMINATED THESE INDICATORS TO THE NEUROSCIENCE COMMUNITY AND SPURRED MAJOR DISCOVERIES OF NOVEL MECHANISMS REGULATING NEUROMODULATOR RELEASE UNDERLYING MOTIVATION AND ADDICTION. BUILD ON THIS INITIAL SUCCESS, WE PROPOSE TO FURTHER EXPAND THE EFFECTIVENESS OF THIS TOOLBOX OF NM SENSORS TO ENABLE IMAGING SPARSE RELEASE AT DEPTH AND SUBCELLULAR RESOLUTION. OUR SPECIFIC GOALS ARE TO (1) IMPROVE THE SENSITIVITY OF OUR CURRENT SENSORS TO ENABLE ROBUST IMAGING OF SPARSE NEUROMODULATOR RELEASE, PUSH THEIR SPATIAL RESOLUTION TO THE SUBCELLULAR LEVEL AND INCREASE LINEARITY OF RESPONSE AT LOWER CONCENTRATIONS; (2) EXPAND THEIR SPECTRAL RANGE TO RED/FAR-RED TO ENHANCE IMAGING DEPTH, SNR AND IN VIVO MULTIPLEX MEASUREMENT AND MANIPULATION OF MULTIPLE CIRCUIT COMPONENTS USING TWO OR THREE DISTINCT COLORS, AND (3) CHARACTERIZE THE POSSIBLE INTERFERENCE OF CURRENT SENSORS WITH ENDOGENOUS SIGNALING AND SYSTEMATICALLY VALIDATE EMERGING SENSORS WITH A WIDE-RANGING MICROSCOPY APPROACHES IN VIVO. OUR STRATEGY RELIES ON A DYNAMIC COLLABORATION BETWEEN THE SENSOR DESIGN TEAM AND END USERS TO OBTAIN CONTINUOUS FEEDBACK TO IMPLEMENT EFFICIENT IMPROVEMENTS TO THE SENSORS. IT IS OUR GOAL TO RAPIDLY DISSEMINATE A WIDE RANGE OF WELL-CHARACTERIZED, HIGHLY SENSITIVE INDICATORS FOR THE NEUROSCIENCE COMMUNITY TO BE EMPLOYED TO STUDY BEHAVING MICE, FISH, FLIES AND WORMS, TO ENRICH OUR KNOWLEDGE ON THE FUNCTIONAL ROLES OF NEUROMODULATORS IN THE BRAIN CIRCUITRY.

ENTITLED CITIES

ADVANCED LEAN BURN MICRO-CHP GENSETS

ENTITLED CITIES

A NOVEL APPROACH TO CRACK NEURONAL MECHANISMS THAT SHAPE COMPUTATIONS IN THE BRAIN - PROJECT SUMMARY LIVING IN THIS EVER-CHANGING ENVIRONMENT, WE CONTINUALLY ADAPT AND LEARN NEW BEHAVIORS. THE COMPUTATION MECHANISMS IN OUR BRAIN MUST BE HIGHLY PLASTIC TO SUPPORT SUCH FLEXIBILITY. PROBLEMS WITH THIS ADAPTIVE PROCESS, ON THE OTHER HAND, RESULT IN INFLEXIBLE AND MALADAPTIVE BEHAVIORS, THE MAIN SYMPTOMS OF ATTENTION-DEFICIT / HYPERACTIVITY DISORDER (ADHD), OBSESSIVE-COMPULSIVE DISORDER (OCD), AND OTHER BRAIN DISORDERS. THE GOAL OF THIS PROPOSAL IS TO ESTABLISH AN EXPERIMENTAL METHOD TO APPROACH WHAT NEURONAL SUBSTRATES AND MECHANISMS SUPPORT OUR FLEXIBLE BEHAVIOR. NEURONAL COMPUTATIONS ARE MEDIATED BY COORDINATED ACTIVITY PATTERNS ACROSS NEURONS, REFERRED TO AS NEURONAL DYNAMICS. WHEN WE LEARN/ADAPT BEHAVIOR, UNDERLYING NEURONAL DYNAMICS CHANGE. THIS RECONFIGURATION OF NEURONAL DYNAMICS IS CONSTRAINED BY SYNAPTIC INTERACTIONS AMONG NEURONS. THUS, CHANGES IN SYNAPTIC INTERACTIONS, OR SYNAPTIC PLASTICITY, LIKELY MEDIATE THE SHAPING OF NEURONAL DYNAMICS AND BEHAVIOR. THEREFORE, NEURONAL DYNAMICS AND SYNAPTIC PLASTICITY ARE TWO PILLARS OF BRAIN FUNCTIONS THAT COOPERATE TO FLEXIBLY ADAPT BEHAVIORS. YET, DYNAMICS AND PLASTICITY HAVE RARELY BEEN STUDIED TOGETHER DUE TO THE LACK OF APPROPRIATE BEHAVIORAL PARADIGMS AND EXPERIMENTAL METHODS TO EXAMINE THEM. TO BRIDGE THIS GAP, I HAVE ESTABLISHED A NOVEL BEHAVIORAL PARADIGM ALONG WITH A PROPOSAL FOR A MOLECULAR SCREENING METHOD TO IDENTIFY THE BRAIN AREAS WHERE SYNAPTIC PLASTICITY IS RESPONSIBLE FOR ADAPTING ACTIONS. ELECTROPHYSIOLOGICAL RECORDINGS AT SUCH BRAIN AREAS COMBINED WITH MANIPULATION OF PLASTICITY WILL ALLOW US TO CRACK A CAUSAL RELATIONSHIP BETWEEN PLASTICITY AND NEURONAL DYNAMICS: WE WILL IDENTIFY WHAT KINDS OF CHANGES IN NEURONAL DYNAMICS ARE INDUCED BY SYNAPTIC PLASTICITY AND HOW THOSE CHANGES RESULT IN IMPROVED BEHAVIOR. BY COMBINING MOLECULAR, SYSTEMS, AND THEORETICAL NEUROSCIENCE METHODS, OUR EXPERIMENTAL APPROACH WILL LINK PLASTICITY, DYNAMICS, AND BEHAVIOR TO EXPLAIN THE ALGORITHMIC BASIS OF FLEXIBLE COMPUTATIONS IN THE BRAIN. IDENTIFYING NEURAL SUBSTRATES CONTROLLING FLEXIBLE BEHAVIORS PROVIDES A FOUNDATION FOR EXAMINING HOW DYSFUNCTIONS OF SUCH SUBSTRATES RESULT IN MALADAPTIVE BEHAVIORS OBSERVED IN VARIOUS BRAIN DISORDERS. OUR NOVEL APPROACH TO COMBINE ELECTROPHYSIOLOGY WITH MANIPULATIONS OF PLASTICITY HAS THE POTENTIAL TO BECOME A NEW STANDARD IN NEUROSCIENCE; AND, LINKING NEURONAL DYNAMICS AND PLASTICITY MAY INSPIRE NOVEL METHODS IN MACHINE LEARNING AND ARTIFICIAL INTELLIGENCE. THUS, OUR FINDINGS AND UNCONVENTIONAL APPROACH WILL HAVE A BROAD IMPACT IN NEUROSCIENCE AND BEYOND.

DARPA ROBOTICS CHALLENGE

THE PURPOSE OF THE COPS HIRING PROGRAM (CHP) PROGRAM IS TO ADVANCE THE PRACTICE OF COMMUNITY POLICING THROUGH THE HIRE OR REHIRE OF ADDITIONAL CAREER LAW ENFORCEMENT OFFICERS. FUNDING UNDER THIS AWARD PROGRAM WILL BE UTILIZED BY LOCAL LAW ENFORCEMENT AGENCIES TO HIRE AND REHIRE CAREER LAW ENFORCEMENT OFFICERS NECESSARY TO INCREASE THE JURISDICTIONS COMMUNITY POLICING CAPACITY TO PREVENT AND DISRUPT CRIME AND VIOLENCE.

NEW AWARD DE-EE0009696 PROJECT TITLED: ''HIGH-FIDELITY SELF-LEARNING TOOL FOR RESIDENTIAL LOAD AND LOAD FLEXIBILITY FORECASTING''

GENERATION MECHANISMS OF MEMORY-RELATED INTERNAL SEQUENCES IN THE HOPPOCAMPAL CA1 REGION - PROJECT SUMMARY/ABSTRACT EPISODIC MEMORY IS THE MEMORY THAT ALLOWS US TO MENTALLY RE-EXPERIENCE SPECIFIC EPISODES FROM OUR PERSONAL PAST. DURING MEMORY ENCODING, THE CONTINUOUS STREAM OF EXPERIENCE IS SEGMENTED INTO INDIVIDUAL EPISODES, WHERE EACH EPISODE ENCODES A SEQUENCE OF EVENTS ORDERED IN TIME. YET, HOW NEURAL CIRCUITS PERFORM COMPUTATIONS TO SEGMENT EXPERIENCE AND ENCODE SEQUENTIALLY OCCURRING EVENTS REMAINS UNKNOWN. REVEALING THE CIRCUIT-LEVEL MECHANISMS BEHIND THESE COMPUTATIONS IS ESSENTIAL FOR UNDERSTANDING EPISODIC MEMORY IN BOTH HEALTH AND DISEASE. IN THE HIPPOCAMPUS, A BRAIN AREA ESSENTIAL FOR EPISODIC MEMORY, NEURONS ARE SEQUENTIALLY ACTIVATED AS AN ANIMAL TRAVELS THROUGH AN ENVIRONMENT. THE SEQUENTIAL FIRING OF THESE SO-CALLED PLACE CELLS REPEATS EACH TIME THE ANIMAL REVISITS THE SAME PATH, AS IF THE ANIMAL’S PREVIOUS EXPERIENCE OF TRAVERSING THE PATH IS RECOLLECTED. HOWEVER, RICH SENSORY CUES ARE PRESENT IN EVERY ENVIRONMENT, MAKING IT DIFFICULT TO ASSESS HOW MUCH OF THE SPIKING ACTIVITY IN THE PLACE CELL SEQUENCE IS INDEPENDENT OF DIRECT SENSORY INPUTS. REVERSIBLY TOGGLE SENSORY INPUTS ON AND OFF DURING LOCOMOTION HAS MADE IT POSSIBLE TO ISOLATE THE SEQUENTIAL ACTIVITY PRODUCED BY THE INTERNAL COMPUTATION (INTERNALLY GENERATED SEQUENCES (IGSS)) FROM THAT DRIVEN BY SENSORY INPUTS. THESE IGSS THAT OCCURRED DURING LOCOMOTION COINCIDE WITH THE PERFORMANCE OF MEMORY TASKS, SUGGESTING THAT THEY ARE MEMORY-RELATED SEQUENTIAL ACTIVITY PATTERNS. INTERESTINGLY, IGSS REOCCUR IN EACH TRIAL OF A MEMORY TASK AND SOMETIMES APPEAR FOLLOWING SPONTANEOUS LOCOMOTION ONSET, IMPLYING THAT HIPPOCAMPUS CAN IDENTIFY BEHAVIOR- LEVEL BOUNDARIES AND ENCODE SPECIFIC SEGMENTS OF EXPERIENCE. REVEALING THE NEURAL CIRCUITS THAT UNDERLIE THE EXPRESSION OF IGSS WITHIN A SEGMENT OF EXPERIENCE SUCH AS A SINGLE BEHAVIOR TRIAL WILL PROVIDE NEW INSIGHT INTO HOW CONTINUOUS EXPERIENCE IS SEGMENTED AND SELECTIVELY ENCODED. THE OBJECTIVE OF THIS STUDY IS TO ELUCIDATE THE CIRCUIT-LEVEL MECHANISMS THAT EVOKE IGSS, AND TEST THE HYPOTHESIS THAT DISTINCT TYPES OF INTERNEURONS IN HIPPOCAMPAL CA1 COORDINATELY MODULATE THE STATE OF THE PYRAMIDAL NEURON POPULATION THUS GATING IGS EXPRESSION. ACCOMPLISHED IN THREE AIMS, WE WILL EMPLOY A MULTIDISCIPLINARY APPROACH ENCOMPASSING THE USE OF IN VIVO FUNCTIONAL RECORDINGS, CELL-TYPE SPECIFIC CHEMOGENETIC AND OPTOGENETIC PERTURBATIONS, AND BEHAVIORAL ANALYSIS TO IDENTIFY THE BEHAVIORAL CONDITIONS REQUIRED FOR IGSS TO OCCUR, AND DETERMINE HOW TWO DISTINCT TYPES OF INTERNEURONS COORDINATE TO SIGNAL THE START OF INTEGRATION AND CONTROL THE WINDOW OF INTEGRATION, THUS GATING THE OCCURRENCE OF IGS. COMPLETION OF THESE AIMS WILL CONTRIBUTE TO NOVEL INSIGHTS INTO HOW NEURAL CIRCUITS OPERATE TO SEGMENT EXPERIENCE AND ENCODE EPISODIC MEMORY, AND WHAT CAN GO WRONG UNDER PATHOLOGICAL CONDITIONS SUCH AS DEMENTIA AND ALZHEIMER’S DISEASE WHERE IMPAIRED EPISODIC MEMORY PROFOUNDLY IMPACTS THE PATIENTS’ QUALITY OF LIFE.

C40 CITIES FINANCE FACILITY

LONG-TERM PLASTICITY EXPRESSED IN LAYER 2/3 CORTICAL MICROCIRCUITS

UNITARY THERMAL ENERGY MANAGEMENT FOR PROPULSION RANGE AUGMENTATION

COPS HIRING RECOVERY PROGRAM

ACTION POTENTIAL SIGNALING IN AXONS OF CNS INTERNEURONS

ENHANCING THE COMPARABILITY OF SHARE WITH HRS AND ELSA

SIEMENS SOFC TEST ARTICLE AND MODULE DESIGN

DEVELOPMENT OF A UNIVERSAL BIOEQUIVALENCE TEST METHOD FOR TOPICAL DRUGS USING DOFM

ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING, AND MISCELLANEOUS GRANTS

SEWER-WATER IMPROVEMENTS

TO DEVELOP AND OPERATE WILDLIFE DETECTION DOG PROGRAMS AT KEY TRANSIT POINTS IN AFRICA TO INTERDICT ILLEGAL WILDLIFE PRODUCTS

MICROFLUIDIC PLATFORM FOR STRESS-INDUCED RAPID ANTIBIOTIC SUSCEPTIBILITY TESTING

METABOLIC REGULATION OF CD8 T CELL MEMORY DEVELOPMENT

TAS::89 0213::TAS NEW AWARD #DE-FE0005666 WITH SIEMENS ENERGY, INC. ENTITLED "CONDITIONED-BASED MONITORING OF TURBINE BLADES DEMONSTRATED IN H-CLASS

TAS::89 0321::TAS NEW FINANCIAL AWARD FRAUNHOFER CENTER FOR SUSTAINABLE ENERGY

IDENTIFYING MITOCHONDRIAL MECHANISMS DRIVING LEARNING AND MEMORY - PROJECT SUMMARY THE OVERALL GOAL IS TO UNDERSTAND THE ENERGY SUPPLY MECHANISMS OF LEARNING AND MEMORY. THE HUMAN BRAIN IS A METABOLICALLY VULNERABLE ORGAN, WHERE EVEN AN ACUTE INTERRUPTION IN ENERGY SUPPLY LEADS TO IMMEDIATE COGNITIVE IMPAIRMENT. THIS ENERGY CONSUMPTION IS PRIMARILY AT NEURONAL SYNAPSES, WHICH REQUIRE ENERGY FOR DIVERSE PROCESSES SUCH AS MAINTAINING ION GRADIENTS, MAKING NEW PROTEINS, AND TRANSPORTING MOLECULES. BECAUSE MOST SYNAPSES ARE PLACED FAR FROM THEIR NEURONAL CELL BODY, MERE ATP DIFFUSION IS INSUFFICIENT TO COPE WITH THE IMMEDIATE (MINUTES) AND SUSTAINED (HOURS) ENERGY DEMANDS OF LOCAL BIOLOGICAL PROCESSES – A LOCAL ENERGY SOURCE IS NECESSARY. CONSISTENT WITH THIS NOTION, MY LAB RECENTLY SHOWED THAT MITOCHONDRIA ARE LOCALLY STABILIZED IN DENDRITES. LOCAL IMPAIRMENT OF STABLE MITOCHONDRIA AFFECTS THE ABILITY OF NEARBY SPINES TO UNDERGO SYNAPTIC PLASTICITY, THE CELLULAR BASIS OF LEARNING AND MEMORY (RANGARAJU ET AL., CELL 2019, BAPAT ET AL., BIORXIV 2023). THEREFORE, SPATIALLY STABLE MITOCHONDRIA ARE ESSENTIAL TO FULFILLING THE CONSTANT LOCAL ENERGY DEMANDS OF SYNAPTIC PLASTICITY FORMATION AND MAINTENANCE. IN LIGHT OF OUR RECENT UNPUBLISHED DATA, WE HYPOTHESIZE THAT MITOCHONDRIA SYNTHESIZE ATP ON-DEMAND DURING SYNAPTIC PLASTICITY, AND THE TEMPORAL AND SPATIAL COORDINATION OF MITOCHONDRIAL ENERGY PRODUCTION NEAR SYNAPSES DICTATES SYNAPTIC PLASTICITY IN TIME AND SPACE. SO FAR, THE KNOWN MECHANISMS OF MITOCHONDRIAL ENERGY PRODUCTION ARE PRIMARILY BASED ON INFORMATION AVERAGED ACROSS ALL SUBCELLULAR COMPARTMENTS, BUT HOW PLASTICITY STIMULI REGULATE SUBCELLULAR ENERGY SUPPLY NEAR SYNAPSES IS UNKNOWN. WE AT THE RANGARAJU LAB WILL DISCOVER NOVEL REGULATORS THAT DICTATE THE FLEXIBILITY OF LOCAL MITOCHONDRIAL ENERGY PRODUCTION IN TEMPORAL (MINUTES TO HOURS) AND SPATIAL (MS OF DENDRITE) SCALES RELEVANT FOR SYNAPTIC PLASTICITY FORMATION AND MAINTENANCE. TO TACKLE THIS CHALLENGE, WE COMBINE RECENT INNOVATIONS IN SUBCELLULAR PROTEOMICS AND CRISPR-BASED SCREENING IN PRIMARY NEURONAL CULTURES. IN ADDITION, WE HAVE DEVELOPED STATE-OF-THE-ART METHODS TO MEASURE ATP SYNTHESIS AND CALCIUM HANDLING IN INDIVIDUAL SPINES AND MITOCHONDRIA AT HIGH SPATIAL AND TEMPORAL RESOLUTION TO CHARACTERIZE SUBCELLULAR (DENDRITES, SPINES) REGULATION OF MITOCHONDRIAL ENERGY PRODUCTION AT DIFFERENT STAGES OF SYNAPTIC PLASTICITY. LASTLY, WE WILL CHARACTERIZE OUR NEWLY IDENTIFIED MECHANISMS IN VIVO IN BEHAVIORAL ASSAYS DURING VARIOUS FORMS OF LEARNING AND MEMORY (SPATIAL, MOTOR, SHORT- AND LONG-TERM). OVERALL, WE WILL SYSTEMATICALLY INVESTIGATE THE SYNAPTIC ENERGY LOGISTICS THAT ALLOW THE BRAIN TO PROCESS AND STORE INFORMATION. AS MITOCHONDRIAL DYSFUNCTION IS OFTEN LINKED TO MEMORY AND COGNITIVE IMPAIRMENT, FILLING THE KNOWLEDGE GAP BETWEEN MITOCHONDRIAL MECHANISMS AND COGNITIVE BEHAVIORS WILL PROVIDE NEW SOLUTIONS TO LEARNING AND MEMORY DISORDERS.

AWARD NUMBER DE-FE0031749 TO SIEMENS CORPORATION FOR PROJECT TITLED ENVIRONMENTAL VALIDATION OF MATERIALS AND DESIGN CONCEPTS TO ENABLE OPERATIONAL FLEXIBILITY OF EXISTING COAL POWER PLANTS

IDENTIFYING NEURONS FOR INTEROCEPTION USING SIMULTANEOUS PROFILING OF ACTIVITY- AND PROJECTION- SPECIFIC POPULATIONS - PROJECT SUMMARY INTEROCEPTION, THE PROCESS BY WHICH THE BODY SENSES ITS OWN INTERNAL STATE, IS CRITICAL TO MAINTAINING HOMEOSTASIS THROUGH THE DETECTION OF PHYSIOLOGICAL CHANGES THAT ENABLE THE BODY TO ADJUST TO CHANGING DEMANDS. DYSFUNCTION IN INTEROCEPTION MAY LEAD TO ERRONEOUS PREDICTION ERRORS CONCERNING THESE BODILY NEEDS AND IS INCREASINGLY CONSIDERED TO UNDERLIE A NUMBER OF MALADAPTIVE BEHAVIORS AND PSYCHIATRIC DISORDERS, INCLUDING ADDICTION AND EATING DISORDERS. DESPITE THIS, LITTLE PROGRESS HAS BEEN MADE IN IDENTIFYING THE UNDERLYING NEURAL CIRCUIT MECHANISMS OF INTEROCEPTION BECAUSE NON-VERBAL SUBJECTS (E.G. ANIMAL MODELS) CANNOT SELF-REPORT INTERNAL STATES. HERE, WE PROPOSE A NOVEL CONCEPTUAL BEHAVIORAL FRAMEWORK FOR STUDYING INTEROCEPTION IN ANIMAL MODELS IN ORDER TO IDENTIFY NEURONAL ENSEMBLES THAT ENCODE INTEROCEPTION. MOREOVER, HUMAN IMAGING STUDIES HAVE INFORMED US THAT INTEROCEPTION RELIES CRITICALLY ON AN UNDERSTUDIED AREA OF THE BRAIN, THE INSULAR CORTEX, BUT THE FUNCTIONS AND CORRESPONDING PROJECTIONS FROM THE INSULAR CORTEX SUBREGIONS (ANTERIOR TO POSTERIOR) HAVE NOT BEEN WELL-STUDIED. METHODS THAT CAN SIMULTANEOUSLY DELIVER PRECISE INFORMATION CONCERNING BEHAVIOR AND PROJECTIONS IN A HIGH-THROUGHPUT WAY ARE THEREFORE REQUIRED. MOLECULAR PROFILING TECHNIQUES HAVE BEEN INCREASINGLY USEFUL FOR IDENTIFYING CELL TYPES THAT MIGHT SERVES AS THE LINK BETWEEN GENES TO CIRCUITS, BUT CURRENT TECHNIQUES HAVE LIMITATIONS, NAMELY THE MODALITY BY WHICH THE PROFILING OCCURS. WE THEREFORE ALSO PROPOSE A NEW TRANSCRIPTOMIC MOLECULAR PROFILING TECHNIQUE, CALLED SNAP-TRAP (SIMULTANEOUS NEURONAL ACTIVITY AND PROJECTION – TRANSLATING RIBOSOME AFFINITY PURIFICATION), THAT ENABLES COINCIDENT PROFILING OF BOTH ACTIVITY-DEPENDENT AND PROJECTION-SPECIFIC NEURONAL MARKERS. WE WILL VALIDATE THIS TECHNIQUE USING A WELL-DEFINED NEURAL CIRCUIT WITH KNOWN MOLECULAR MARKERS AND BEHAVIORAL CONSEQUENCES. WE WILL THEN APPLY THE METHODOLOGY TO THE INSULAR CORTEX AND ITS ROLE IN INTEROCEPTION. THIS TECHNIQUE WILL ALSO ENABLE US TO MAKE COMPARISONS OF NEXT-GENERATION RNA-SEQUENCING TO SINGLE- CELL RNA SEQUENCING FOR THE PURPOSE OF IDENTIFYING USEFUL MARKERS FOR BEHAVIORAL VALIDATION. LASTLY, WE WILL MAP OUR FINDINGS BACK ONTO TISSUE SECTIONS TO ACHIEVE SPATIAL TRANSCRIPTOMIC INFORMATION. THROUGH THESE EXPERIMENTS WE HOPE TO ACHIEVE A COMPREHENSIVE TRANSCRIPTOMIC MAP OF THE INSULAR CORTEX THAT CAN BE PRECISELY DELINEATED ACCORDING TO PARTICULAR BEHAVIORS AND PROJECTIONS, AND CAN BE USED AS A BASIS FOR UNDERSTANDING HOW DYSFUNCTION IN INTEROCEPTION LEADS TO MALADAPTIVE BEHAVIORS. THE SNAP- TRAP TECHNIQUE MAY THEN BE USED BY THE BROADER NEUROSCIENCE COMMUNITY IN OTHER BRAIN REGIONS AND BEHAVIORAL TASKS TO GAIN INSIGHTS INTO THE NEURAL UNDERPINNINGS OF COMPLEX BEHAVIORS AND THEIR ASSOCIATED PSYCHIATRIC DISORDERS.

COMBAT WILDLIFE TRAFFICKING WITH AERIAL INITIATIVE FOR REDUCTION AND PREVENTION OF INTERNATIONAL TRAFFICKING IN ZAMBIA

DYNAMICS OF INFLUENZA A VIRUS DEFECTIVE INTERFERING PARTICLE REPLICATION - FROM SINGLE CELLS AND TISSUES TO THE HOST LEVEL (DIA_TIP)

OPTOGENETIC SIGNALING INHIBITORS FOR STUDYING BRAIN PLASTICITY

OPTIMIZED CLINICAL DERMAL OPEN FLOW MICROPERFUSION STUDY DESIGN TO DEMONSTRATE BIOEQUIVALENCE BASED ON CUTANEOUS PHARMACOKINETICS - PROJECT SUMMARY/ABSTRACT TOPICALLY APPLIED DRUG PRODUCTS (TADPS) HAVE EXPERIENCED AN EXTRAORDINARY PRICE INCREASE IN THE USA, MOSTLY DUE TO A LACK OF GENERIC TADPS. DEVELOPMENT OF GENERIC TAPDS IS HINDERED BY HIGH COSTS AND RISK ASSOCIATED WITH CLINICAL ENDPOINT STUDIES REQUIRED TO SHOW BIOEQUIVALENCE (BE) OF PROSPECTIVE GENERIC TADPS TO THEIR REFERENCE PRODUCTS. THE BARRIER TO DEVELOP A GENERIC TADP HAS BEEN REDUCED BY THE INTRODUCTION OF A CHARACTERIZATION-BASED BE APPROACH BY US-FDA. FOLLOWING THIS IN-VITRO APPROACH, GENERIC PRODUCTS WHOSE COMPONENTS (Q1), COMPOSITION (Q2), AND ARRANGEMENT OF MATTER (Q3) ARE PRECISELY MATCHED TO THOSE OF THE REFERENCE PRODUCT ARE DEVELOPED, AND BE MAY BE SHOWN BY COMBINATIONS OF IN VITRO RELEASE TESTING, IN VITRO PERMEATION TESTING AND Q3 CHARACTERIZATION. UNFORTUNATELY, A SIGNIFICANT PART OF TADPS DO NOT QUALIFY FOR THIS IN-VITRO OPTION AS THEY CANNOT MATCH SAMENESS WITH REGARD TO THE COMPONENT CONCENTRATIONS WITHIN THE REQUIRED +/- 5% WINDOW. THERE IS AN URGENT NEED FOR ALTERNATIVES TO SHOW BE FOR TADPS IN WHICH THERE IS UNCERTAINTY IN THE MATCHING OF Q2 AND Q3 BETWEEN THE GENERIC AND REFERENCE PRODUCT, AND FOR NON-Q1/NON-Q2/Q3 GENERIC TADPS, ESPECIALLY FOR Q1 AND Q2 SIMILAR PRODUCTS. THE MULTIDISCIPLINARY PROJECT BEOFM WILL CONTINUE THE WORK OF TWO SUCCESSFULLY FINISHED US-FDA CO-FUNDED PROJECTS, IN WHICH DERMAL OPEN FLOW MICROPERFUSION (DOFM) HAS SHOWN ITS POTENTIAL TO ACCURATELY AND SENSITIVELY ASSESS THE RATE AND EXTENT OF DRUGS AT OR NEAR THEIR SITE OF ACTION, AND IN WHICH DOFM WAS ABLE TO SHOW CUTANEOUS BE FOR SEVERAL TADPS TO THEMSELVES AND TO US-FDA APPROVED GENERIC TADPS BEARING APIS SUCH AS ACYCLOVIR, LIDOCAINE, PRILOCAINE, AND DICLOFENAC. BEOFM WILL ELUCIDATE THE IMPACT OF DRUG RESIDENCE TIME ON DRUG PK IN THE STRATUM CORNEUM, EPIDERMIS, AND DERMIS, AND THE RELATIONSHIP BETWEEN THE FREE DRUG VERSUS PROTEIN-BOUND DRUG SAMPLED WITH DIFFERENT CONTINUOUS SAMPLING TECHNIQUES (DOFM, DERMAL MICRODIALYSIS (DMD), EPIDERMAL MICROFLUIDICS (EMF)) AS WELL AS TAPE STRIPPING AND DEPTH-RESOLVED SKIN BIOPSIES IN PARALLEL. FURTHER, BEOFM WILL DEVELOP AND IMPLEMENT PK MODELS OPTIMIZED FOR DOFM/DMD THAT ARE ABLE TO PREDICT DOFM/DMD PK PROFILES, INCLUDING APPROPRIATE PK ENDPOINTS FOR ESTABLISHING BE USING CUTANEOUS PK-BASED APPROACHES FOR TOPICAL DRUGS THAT MAY NOT REACH THE MAXIMUM DRUG CONCENTRATION WITHIN 24 HOURS POST-ADMINISTRATION. ALL PROJECT RESULTS WILL BE COMBINED IN THE OVERALL GOAL TO DEVELOP A UNIVERSAL, STANDARDIZED APPROACH FOR COST- AND TIME-OPTIMIZED CLINICAL CUTANEOUS BE STUDY DESIGNS USING DOFM AND DMD. THE APPLICABILITY OF THIS NEW APPROACH WILL BE VERIFIED BY PERFORMING A CUTANEOUS BE DOFM STUDY OF A TADP THAT HAS NOT BEEN INVESTIGATED CLINICALLY BY DOFM SO FAR. BEOFM WILL BUILD THE SCIENTIFIC BASIS FOR CUTANEOUS BE STUDIES USING DERMAL CONTINUOUS SAMPLING TECHNIQUES FOR Q1 AND Q2 SIMILAR PRODUCTS THAT DO NOT QUALIFY FOR THE IN-VITRO APPROACH, THUS REDUCING EXISTING BARRIERS IN GENERIC TADP DEVELOPMENT/APPROVAL AND HELP TO INCREASE THE AVAILABILITY OF HIGH-QUALITY AND AFFORDABLE GENERIC TADPS. 1

SHAFTER-WASCO IRRIGATION DISTRICT, KIMBERLINA PIPELINE CONVEYANCE IMPROVEMENT PROJECTRECLAMATION FUNDING: 1,315,083 TOTAL PROJECT COST: 2,630,166THE SHAFTER-WASCO IRRIGATION DISTRICT (DISTRICT), LOCATED IN KERN COUNTY, CALIFORNIA, WILL CONSTRUCTTHE KIMBERLINA PIPELINE CONVEYANCE IMPROVEMENT PROJECT. THE DISTRICT WILL INSTALL 1,400 LINEARFEET OF PIPELINE TO CONNECT THE DISTRICTS NORTH MAINLINE DISTRIBUTION SYSTEM TO THE KIMBERLINARECHARGE FACILITY TO ALLOW WATER SUPPLIES TO BE DELIVERED FROM THE FRIANT KERN CANAL. OVERALL,THE PROJECT WILL ALLOW AN ADDITIONAL 5,850 ACRE-FEET PER YEAR OF RECHARGE AND GROUNDWATERSTORAGE DURING WET YEARS THAT CAN BE RECOVERED FOR BENEFICIAL USE DURING DRY YEARS. THIS PROJECTIS SUPPORTED BY THE POSO CREEK INTEGRATED REGIONAL WATER MANAGEMENT PLAN AND DROUGHTCONTINGENCY PLAN THAT WAS DEVELOPED WITH ASSISTANCE FROM A WATERSMART DROUGHTCONTINGENCY PLANNING GRANT.

SPATIALLY MULTIPLEXED BIOGEL NANOSENSORS WITH BORON-DOPED DIAMOND MICROELECTRODE ARRAYS FOR HIV SELF-TESTING - PROJECT SUMMARY THE CLINICAL STUDIES DEMONSTRATING THAT WHEN PEOPLE MAINTAIN UNDETECTABLE LEVELS OF VIRAL LOADS, HIV CANNOT TRANSMIT PROVIDED AN EXCITING NEW DIRECTION FOR HIV MANAGEMENT. A CENTRAL PART OF HIV HEALTH CARE WILL BE TO DEVELOP THE TECHNOLOGY REQUIRED FOR HOME TESTING OF HIV VIRAL LOADS SIMILAR TO DIABETES MANAGEMENT. THERE ARE SEVERAL REQUIREMENTS FOR SUCH A HOME TEST. FIRST, SAMPLE PREPARATION OF VIRUS MUST CLEANLY ISOLATE VIRUS-LADEN PLASMA WITHOUT LYSING WHITE BLOOD CELLS OR REQUIRE ANY LAB EQUIPMENT. SECOND, THE TEST MUST STORE REAGENTS ON- CHIP AT AMBIENT CONDITIONS OVER LONG PERIODS. THIRD, THE TEST MUST PROVIDE ACCURATE AND IDEALLY, SEMI-QUANTITATIVE INFORMATION WITHOUT REQUIRING EXTENSIVE MANIPULATION, TRAINING, OR EXPENSIVE INSTRUMENTATION. CURRENT DIAGNOSTICS CANNOT MEET THESE REQUIREMENTS. THE HIGHEST VALUE TEST IS NUCLEIC ACID AMPLIFICATION BUT THE ENZYMES AND BUFFERS REQUIRE COLD CHAIN STORAGE, TRAINED PERSONNEL, AND FREQUENTLY, FLUORESCENCE-BASED INSTRUMENTATION. ANTIBODY- BASED TESTS FOR VIRAL CAPTURE ON LATERAL FLOW ARE HAMPERED BY LOWER ANALYTICAL SENSITIVITY AND SPECIFICITY VALUES, ARE NOT QUANTITATIVE, AND ARE HAMPERED BY PROTEIN RATHER THAN NUCLEIC ACID-BASED MANUFACTURING INFRASTRUCTURES. HERE WE PROPOSE THE INTEGRATION OF OUR NOVEL BIOGEL NANOSENSORS AND BORON-DOPED DIAMOND MICROELECTRODE ARRAYS TO DIRECTLY PROVIDE ACTIONABLE, SEMI-QUANTITATIVE, HIV VIRAL LOAD INFORMATION FOR THE HOME USER. OUR HYDROGEL ENCAPSULATES AND LOCKS IN NAAT TESTS IN AQUEOUS ENVIRONMENTS WITHOUT OIL OR MANUFACTURING ADDITIONAL COMPARTMENTS. THE GEL PROVIDES SAFE, ON-CHIP STORAGE OF REAGENTS AND CRITICALLY, IS PRINTABLE FOR RAPID FABRICATION OF ARRAYS FOR DIGITAL QUANTITATION. THE GEL IS ALSO SPECIFICALLY POSITIVELY CHARGED TO ATTRACT AND CONCENTRATE VIRAL GENOMES FROM THE RAW SAMPLE WHICH WOULD IMPROVE THE LOD95. IN OUR PROPOSED PLATFORM, A BORON-DOPED DIAMOND MICROELECTRODE UNDERLIES EACH SPOT IN THE ARRAY. THIS WILL PROVIDE AN INDIVIDUAL, ELECTROCHEMICAL READOUT FOR EVERY SPOT WHICH CAN BE INTERPRETED IN A DIGITAL FORMAT FOR POTENTIAL QUANTIFICATION. WITH THIS PLATFORM, THE USER SIMPLY ADDS BLOOD FROM A FINGERSTICK AND USES A MEMBRANE TO SEPARATE OUT THE PLASMA. A SECOND WICKING MEMBRANE WITH LYSIS REAGENTS DELIVERS VIRAL GENOMES TO THE BIOGEL NANOSENSOR ARRAY VIA LATERAL FLOW. TOGETHER, THE EASE OF USE, ON-CHIP STORAGE, CREATION OF A DIGITAL ELECTROCHEMICAL READOUT, AND COMPATIBILITY WITH MANUFACTURING INFRASTRUCTURES TO KEEP COSTS LOW YIELDS A PROMISING, VIABLE PLATFORM FOR HIV MANAGEMENT AT HOME.

VARIAN MEDICAL SYSTEMS G.M.B.H. ''2018 - 2023 SUPPORT FOR THE OPERATIONS OF A LINEAR ACCELERATOR FOR THE DOSIMETRY LABORATORY OF THE INTERNATIONAL ATOMIC ENERGY AGENCY'' *NEW GRANT

CHP

TAS::57 3600::TAS "ADVANCING ATTOSECOND SOLID STATE PHYSICS TOWARDS PETAHERTZ ELECTRONICS" (THE GRANTEE'S TECHNICAL PROPOSAL)

HOME INVESTMENT CPD

HOMELESS PREVENTION & REHSNG

MACROPHAGE FATTY ACID METABOLISM IN IMMUNITY TO HELMINTHS

NEOGROWTH SILICON: US MANUFACTURING OF SOLAR WAFERS

HOME INVESTMENT CPD

FDA PHARMACEUTICAL MANUFACTURING QUALITY METRICS RESEARCH

PHYSICS-BASED INTERVAL DATA MODELS TO AUTOMATE AND SCALE HOME ENERGY PERFORMANCE EVALUATIONS

CRCNS: ROLE OF MACHRS ON CA 1 PYRAMIDAL NEURONS IN MEMORY FORMATION AND STABILITY - THE FORMATION AND RETENTION OF MEMORIES OF OUR DAILY EXPERIENCES DEPEND ON A BRAIN REGION CALLED THE HIPPOCAMPUS. AMONG THE EXTENSIVE NEUROMODULATORY INPUTS THE HIPPOCAMPUS RECEIVES, CHOLINERGIC INPUTS FROM THE BASAL FOREBRAIN ARE CRUCIAL FOR LEARNING AND MEMORY. THESE SAME INPUTS ELICIT REDUCED NEURONAL RESPONSE WITH AGING, AND DEGENERATE IN PATIENTS SUFFERING FROM ALZHEIMER'S DISEASE. DESPITE ITS CRITICAL ROLE IN MEMORY FORMATION AND STABILITY, HOW CHOLINERGIC MODULATION MEDIATES MEMORY FUNCTIONS THROUGH INDIVIDUAL CIRCUIT ELEMENTS IN THE HIPPOCAMPUS REMAINS LARGELY UNKNOWN. IN CA 1, THE MAJOR OUTPUT OF THE HIPPOCAMPUS, ACETYLCHOLINE RECEPTORS ARE EXPRESSED IN MULTIPLE CELL TYPES AND CELLULAR COMPARTMENTS. UNTIL NOW, IT HAS BEEN DIFFICULT TO DETERMINE THE CONTRIBUTION OF INDIVIDUAL ELEMENTS TO THE OVERALL NETWORK EFFECTS OF ACETYLCHOLINE. IN THIS PROJECT, WE WILL STUDY THE ROLE OF MUSCARINIC CHOLINERGIC RECEPTORS LOCATED ON THE PYRAMIDAL NEURONS OF THE CA1 REGION IN THE FORMATION AND LONG-TERM STABILITY OF INTERNALLY GENERATED SEQUENCES (IGS), THE SEQUENCES GENERATED DURING LOCOMOTION WHILE SENSORY CUES ARE HELD CONSTANT AND AS ANIMALS PERFORM MEMORY TASKS. WE WILL USE IGS AS A REPRESENTATIVE OF MEMORY-RELATED ACTIVITY PATTERNS TO REVEAL HOW CHOLINERGIC ACTIVITY MODULATES THE FORMATION OF AND THE LONG TIMESCALE DRIFT IN THE HIPPOCAMPAL CODE AND IN TURN REFINES THE BEHAVIOR BY ACTIVATING CELL-TYPE-SPECIFIC ACETYLCHOLINE RECEPTORS. OUR EXPERIMENTAL APPROACH IS TO MANIPULATE THE STRENGTH AND LOCUS OF CHOLINERGIC MODULATION IN CA1 WHILE IMAGING LARGE NUMBERS OF NEURONS IN AWAKE HEAD-FIXED MICE ENGAGED IN A HIPPOCAMPUS-DEPENDENT MEMORY TASK. SPECIFICALLY, WE WILL SELECTIVELY MODULATE THE CA1 PYRAMIDAL NEURONS WITH CELL-TYPE SPECIFIC NEUROPHARMACOLOGICAL TOOLS. INTEGRATING COMPUTATIONAL MODELING WITH FINDINGS FROM EXPERIMENTS, WE WILL ELUCIDATE POSSIBLE PLASTICITY AND NETWORK MECHANISMS RESPONSIBLE FOR THE OBSERVED NEURONAL DYNAMICS. BY COMBINING EXPERIMENTAL AND COMPUTATIONAL APPROACHES TO ELUCIDATE THE CHOLINERGIC CONTROL OF PLASTICITY OVER MEMORY FORMATION AND STABILITY ACROSS THE CELLULAR, CIRCUIT, AND BEHAVIORAL LEVELS, WE WILL CONTRIBUTE NOVEL INSIGHTS INTO THE EFFECTS OF A DISRUPTION IN CHOLINERGIC SIGNALING. OUR RESULTS MAY INDICATE WHICH PHYSIOLOGICAL PARAMETERS COULD BE ALTERED TO COMPENSATE FOR THE LOSS OF CHOLINERGIC SIGNALS, AND LEAD TO THE DEVELOPMENT OF NEW TREATMENT OPTIONS FOR MEMORY DISORDERS.

THE OBJECTIVE OF THE PROJECT IS TO BUILD, DEPLOY AND DEMONSTRATE IN-USE PERFORMANCE OF A CLASS 6/7, MEDIUM-DUTY ZERO-EMISSION (ZE) SALT/SNOWPLOW TRUCK TO ENABLE COMMERCIALIZATION OF A CRITICAL TRUCK MARKET SEGMENT REQUIRED IN COLD-WEATHER REGIONS ACROSS THE UNITED STATES. THIS PROJECT WILL NOT ONLY HELP TO ENSURE THE PASSENGER AND ROAD SAFETY THIS APPLICATION PROVIDES TO OUR COMMUNITIES DURING SNOW AND ICY WEATHER EVENTS, BUT ALSO TO ENSURE THAT THE ENERGY DEMAND (KWH) REQUIRED TO SUCCESSFULLY MAINTAIN CITY ROADS CAN BE MET.

PARD

CONDITIONS BASED MONITORING OF TURBINE COMBUSTION COMPONENTS

SUPPORT OF BLACK RHINOCEROS MONITORING AND PROTECTION IN THE GREATER SERENGETI ECOSYSTEM AND MKOMAZI NATIONAL PARK, NORTHERN TANZANIA.

TUMOR-IMPOSED GLUCOSE RESTRICTIONS ON T CELLS DAMPEN IMMUNITY

NEURAL CIRCUIT MECHANISMS CONTROLLING NON-HOMEOSTATIC FEEDING - PROJECT SUMMARY COMPULSIVE EATING IS A MAJOR CONTRIBUTOR TO THE OBESITY EPIDEMIC IN THE US, AS OVER 35% OF ADULTS ARE NOW CLASSIFIED AS OVERWEIGHT OR OBESE. BEHAVIORAL OUTCOMES SUCH AS COMPULSIVE EATING DERIVE FROM A COMPLEX INTERACTION OF GENETICS, INNATE BEHAVIORS AND LEARNING ABOUT PREVIOUS EXPERIENCES. CUE-FOOD ASSOCIATIONS (E.G. ADVERTISING, EATING IN FRONT OF THE TELEVISION, ETC.) THAT ARE FORMED DURING PERIODS OF HUNGER LEAD TO LONG-LASTING MEMORIES THAT CONTROL NON-HOMEOSTATIC OVERCONSUMPTION. HOWEVER, THE NEURAL CIRCUITRY, AND SPECIFICALLY THE MOLECULAR CELL TYPES, GOVERNING THIS BEHAVIOR ARE NOT WELL DEFINED. USING AN ORIGINAL PARADIGM THAT INDUCED OVERCONSUMPTION IN SATED MICE WITH CONTEXTUAL CUES, I HAVE ESTABLISHED A ROLE OF THE INSULAR CORTEX, AND SPECIFICALLY NOS1 NEURONS WITHIN THE INSULAR CORTEX, AS CRITICAL MEDIATORS OF LEARNED OVERCONSUMPTION. THESE NEURONS DO NOT PLAY A ROLE IN HOMEOSTATIC FEEDING ITSELF AND ARE THEREFORE HYPOTHESIZED TO PROVIDE TOP DOWN CONTROL OF HOMEOSTATIC FEEDING CIRCUITRY TO CONTROL FOOD INTAKE. MOREOVER, A PROJECTION FROM THE INSULAR CORTEX TO THE CENTRAL AMYGDALA IS NECESSARY TO GENERATE THIS OVERCONSUMPTION RESPONSE. UNDER THE PRIMARY MENTORSHIP OF DR. JEFFREY FRIEDMAN AT THE ROCKEFELLER UNIVERSITY AND THE CO-MENTORSHIP OF DR. DENISE CAI AT THE ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, I WILL CONTINUE TO BUILD ON MY BEHAVIORAL AND MOLECULAR NEUROSCIENCE EXPERTISE WHILE DEVELOPING MY TRAINING IN OPTOGENETICS AND IN VIVO CALCIUM IMAGING. IN THE MENTORED K-PHASE OF THIS GRANT, I WILL ANALYZE THE ROLE OF A MOLECULARLY DEFINED CORTICAL-AMYGDALAR CIRCUIT IN OVERCONSUMPTION USING OPTOGENETICS AND CALCIUM IMAGING TECHNIQUES. I WILL ALSO DETERMINE THE AMYGDALA TARGETS OF INSULAR CORTEX NOS1 NEURONS. IN THE INDEPENDENT PHASE (R00), I WILL UTILIZE RETROGRADE TRACING TECHNIQUES TO EXAMINE THE REGIONS AND MOLECULARLY PROFILE THE CELL TYPES THAT DIRECTLY PROJECT TO THE INSULAR CORTEX NEURONS THAT CONTROL OVERCONSUMPTION, AND TEST CAUSALLY HOW THEY ARE FUNCTIONALLY INVOLVED IN NON-HOMEOSTATIC FEEDING. TOGETHER, THESE DATA WILL ESTABLISH A CELL-TYPE SPECIFIC CIRCUIT THROUGH THE INSULAR CORTEX THAT CONTROLS OVERCONSUMPTION IN RESPONSE TO ENVIRONMENTAL STIMULI. THIS DATA WILL EXPAND THE KNOWLEDGE OF HIGHER-ORDER BRAIN REGIONS INVOLVED IN FEEDING BEHAVIOR AND MAY LEAD TO THE DEVELOPMENT OF NOVEL THERAPEUTIC AVENUES TO CONTROL OVEREATING. AT THE SAME TIME, THE RESEARCH AND TRAINING PLANS PROPOSED IN THIS APPLICATION WILL ENABLE ME TO DEVELOP MY TECHNICAL AND PROFESSIONAL SKILLS IN ORDER TO TRANSITION TO AN INDEPENDENT RESEARCH POSITION. WITH THE SUCCESSFUL COMPLETION OF THIS PROJECT, I WILL HAVE DEVELOPED A PLATFORM FOR A FULLY INDEPENDENT RESEARCH PROGRAM AIMED AT UNDERSTANDING HOW THE BRAIN COORDINATES THE INTERPLAY BETWEEN INNATE AND LEARNED BEHAVIORS THAT DRIVE MALADAPTIVE CHOICES.

PHOTOVOLTAICS RESEARCH AND DEVELOPMENT (PVRD) 2: MODULES AND SYSTEMS

CITIES RECOVERY

THE PURPOSE OF THIS PROJECT IS TO INCREASE THE OPERATIONAL EFFICIENCY OF THE RECENTLY CREATED LOMAMI NATIONAL PARK (LNP), DEMOCRATIC REPUBLIC OF CONGO. THE LNP HARBORS SEVERAL ICONIC ENDEMIC SPECIES INCLUDING BONOBO, OKAPI, AND CONGO PEACOCK AS WELL AS A STABLE POPULATION OF FOREST ELEPHANT. THE PROJECT AIMS TO EXTEND WILDLIFE MANAGEMENT INTO THE CURRENT BUFFER ZONE THROUGH ESTABLISHMENT OF COMMUNITY RESERVES WHILE INCREASING COLLABORATION WITH SURROUNDING COMMUNITIES TO ENSURE BETTER PROTECTION FOR THE PARK AS WELL. ACTIVITIES INCLUDE (1) IMPROVING MANAGEMENT AND MONITORING SYSTEMS WITHIN LNP (2) SUPPORTING COMMUNITIES IN PARTICIPATORY MAPPING OF AND DEVELOPMENT OF MANAGEMENT PLANS FOR COMMUNITY CONCESSIONS IN THE BUFFER ZONE AND (3) CONDUCTING REGULAR MONITORING AND SURVEYS OF KEY WILDLIFE POPULATIONS AND STATUS OF THREATS.

TAS::97 0400::TAS SYMBOLIC GENERATION OF SECURE CONFIGURATIONS (SYGESEC)

GEMEINSCHAFT REENTRY OPPORTUNITIES FOR WOMEN (GROW)

NYERERE NATIONAL PARK NNP AND SELOUS GAME RESERVE SGR ARE SOME OF AFRICAS OLDEST AND LARGEST PROTECTED AREAS LOCATED IN THE SOUTHEASTERN PART OF TANZANIA WITH A TOTAL AREA CLOSE TO 50000 KM2. SGR AND NNP FORM THE CORE OF AN EVEN LARGER NETWORK OF PROTECTED AND CONSERVATION AREAS THE NYERERESELOUS ECOSYSTEM ALSO INCLUDES 10 COMMUNITY WILDLIFE MANAGEMENT AREAS AND IS APPROXIMATELY 110000 KM2. ELEPHANTS RANGE ACROSS THIS ENTIRE SYSTEM. THE PURPOSE OF THE PROJECT IS TO STRENGTHEN SGR AND NNP PROTECTION AND HUMANELEPHANT CONFLICT RESPONSE CAPACITY TO ENSURE THE RECOVERY AND LONGTERM SURVIVAL OF THIS CONTINENTALLY IMPORTANT POPULATION WHILE PRIORITIZING THE SAFETY OF THE COMMUNITIES COEXISTING WITH ELEPHANTS. THROUGH THE PROVISION OF AERIAL SUPPORT TO PATROL THESE VAST PROTECTED AREAS AND SUPPORT TO RANGERS MOBILITY THROUGH THE MAINTENANCE OF PATROL VEHICLES ANTIPOACHING EFFORTS FOR SGR AND NNP WILL BE STRENGTHENED. THIS PROJECT PRIORITIZES THE SAFETY OF COMMUNITIES IN THE LANDSCAPE BY WORKING CLOSELY WITH TANZANIAN AUTHORITIES AND COMMUNITIES TO INCREASE THE NUMBER AND CAPACITY OF RESPONSE TEAMS. FINALLY BY PROVIDING SUPPORT FOR THE MONITORING OF ELEPHANTS AND PRELIMINARY STAKEHOLDER ECOSYSTEM PLANNING THIS PROJECT WILL INITIATE A PROCESS OF FINDING LONGTERM SOLUTIONS TO HUMANELEPHANT COEXISTENCE.

TAS::89 0321::TAS OFFSHORE 12 MW TURBINE ROTOR WITH ADVANCED MATERIALS AND PASSIVE DESIGN CONCEPTS

VERSATILE NEXT-GENERATION ATOM ARRAY PROCESSORS

CRCNS: US-GERMAN RES PROP: THE ROLE OF SPONTANEOUS ACTIVITY IN CORTICAL DEVELOPMENT

DIAMOND SIC COMPOSITES DATED

LOW NOX COMBUSTER DESIGN FOR 65% EFFICIENT ENGINE

COMBATING WILDLIFE TRAFFICKING ZAMBIA LUANGWA ZAMBEZI

SHAFTER WASCO IRRIGATION DISTRICT - DILZ INTERTIE

DEVELOPMENT OF A BIO-BASED, INEXPENSIVE, NONCORROSIVE, NONFLAMMABLE PHENOLIC FOAM FOR BUILDING INSULATION

IMMEDIATE USE OF INTRAVENOUS OMEGA-3FATTY ACIDS FOLLOWING BLAST INDUCED TBI

SECURING THE GREATER NORTH LUANGWA LANDSCAPE FOR THE PROTECTION OF BLACK RHINOS (DICEROS BICORNIS MINOR) IN NORTH LUANGWA NATIONAL PARK, ZAMBIA

RADIAL APPROACH TO THE AUTOMATED SYNTHESIS OF SMALL MOLECULES

BORON-DOPED DIAMOND ELECTRODE ARRAYS FOR MALARIA DETECTION IN SALIVA AND URINE

THE PURPOSE OF THIS PROJECT IS TO CONTINUE DEVELOPING, EVALUATING, AND TRANSFERRING STATE-OF-THE-ART SOFTWARE ENGINEERING TECHNOLOGIES IN SUPPORT OF

SHAFTER-WASCO IRRIGATION DISTRICT, SOUTHEAST RECHARGE FACILITY AND CONVEYANCE IMPROVEMENTS RECLAMATION FUNDING: 500,000 TOTAL PROJECT COST: 1,257,735 THE SHAFTER-WASCO IRRIGATION DISTRICT (DISTRICT), LOCATED IN KERN COUNTY, CALIFORNIA, WILL CONSTRUCT THE SOUTHEAST RECHARGE FACILITY CONSISTING OF A 37-ACRE RECHARGE BASIN AND 1,050 LINEAR FEET OF PIPELINE TO CONNECT THE BASIN TO THE DISTRICT S DISTRIBUTION SYSTEM. BY INCREASING GROUNDWATER RECHARGE IN WET YEARS FOR LATER BENEFICIAL USE DURING DRY YEARS, THE PROJECT WILL ENHANCE DROUGHT RESILIENCY, INCREASE OPERATIONAL EFFICIENCIES, AND IMPROVE SYSTEM FUNCTIONALITY. THROUGH THE IMPLEMENTATION OF THE PROJECT, THE DISTRICT EXPECTS TO INCREASE GROUNDWATER RECHARGE CAPABILITIES AND CONVEYANCE CAPACITY BY AN AVERAGE OF 1,200 ACRE-FEET PER YEAR. THIS PROJECT IS SUPPORTED BY THE POSO CREEK INTEGRATED REGIONAL WATER MANAGEMENT PLAN AND DROUGHT CONTINGENCY PLAN THAT WAS DEVELOPED WITH ASSISTANCE FROM A WATERSMART DROUGHT CONTINGENCY PLANNING GRANT.

CONVEYANCE IMPROVEMENTS TO FARMERS COOPERATIVE RECHARGE

ERASE-PFAS: MECHANISTIC STUDY OF THE ELECTROCHEMICAL OXIDATION OF PER AND POLYFLUORINATED ALKYL SUBSTANCES TO GUIDE ELECTRODE DESIGN -PER- AND POLYFLUOROALKYL SUBSTANCES (PFAS), ALSO KNOWN AS ?FOREVER CHEMICALS,? ARE HARMFUL POLLUTANTS THAT DO NOT BREAK DOWN EASILY AND CAN CONTAMINATE DRINKING WATER. THIS PROJECT WILL IMPROVE A TREATMENT METHOD CALLED ELECTROCHEMICAL OXIDATION, WHICH USES ELECTRODES MADE OF DIAMOND TO DESTROY PFAS AND TURN THEM INTO SAFER COMPOUNDS. ALONG WITH SCIENTIFIC PROGRESS, THE PROJECT WILL SUPPORT STEM EDUCATION BY TRAINING BOTH UNDERGRADUATE AND GRADUATE STUDENTS AND OFFERING OUTREACH PROGRAMS AND WORKSHOPS. THESE EFFORTS WILL HELP PREPARE A SKILLED WORKFORCE TO ADDRESS MAJOR ENVIRONMENTAL PROBLEMS. THE PROJECT WILL ALSO SUPPORT GLOBAL TEAMWORK BY CONNECTING RESEARCHERS, STUDENTS, AND INDUSTRY PROFESSIONALS TO FIND BETTER WAYS TO HANDLE PFAS POLLUTION. THIS PROJECT AIMS TO ADVANCE THE SCIENTIFIC UNDERSTANDING AND PRACTICAL APPLICATION OF ELECTROCHEMICAL OXIDATION (EO) USING BORON-DOPED DIAMOND (BDD) ELECTRODES FOR THE DESTRUCTION OF PER- AND POLYFLUOROALKYL SUBSTANCES (PFAS); A CLASS OF ENVIRONMENTALLY PERSISTENT AND CHEMICALLY STABLE SYNTHETIC POLLUTANTS. PFAS, INCLUDING COMPOUNDS SUCH AS PERFLUOROOCTANOIC ACID (PFOA) AND PERFLUOROOCTANESULFONIC ACID (PFOS), ARE HIGHLY RESISTANT TO CONVENTIONAL CHEMICAL, PHYSICAL, AND BIOLOGICAL TREATMENT PROCESSES, MAKING THEIR REMOVAL FROM DRINKING WATER AND WASTEWATER PARTICULARLY CHALLENGING. THE PROPOSED RESEARCH SEEKS TO ADDRESS CURRENT LIMITATIONS IN EO TREATMENT BY INVESTIGATING THE MECHANISTIC BASIS OF PFAS DEGRADATION AT BDD ELECTRODE SURFACES, AND BY OPTIMIZING ELECTRODE DESIGN AND TREATMENT CELL CONFIGURATION TO IMPROVE PFAS MINERALIZATION EFFICIENCY. THE PROJECT IS STRUCTURED AROUND THE FOLLOWING TECHNICAL OBJECTIVES: (1) ELUCIDATE THE FUNDAMENTAL DEGRADATION MECHANISMS AND KINETICS OF PFAS DURING EO, WITH A FOCUS ON BOTH DIRECT ELECTRON TRANSFER AND INDIRECT OXIDATION PATHWAYS INVOLVING HYDROXYL RADICALS; (2) EVALUATE THE INFLUENCE OF OPERATIONAL PARAMETERS INCLUDING APPLIED POTENTIAL, CURRENT DENSITY, ELECTROLYTE COMPOSITION, FLOW DYNAMICS, AND ELECTRODE SURFACE MORPHOLOGY, ON PFAS DEGRADATION RATES AND ENERGY EFFICIENCY; (3) DESIGN AND FABRICATE NOVEL BDD ELECTRODE ARCHITECTURES AND FLOW-THROUGH REACTOR CONFIGURATIONS THAT ENHANCE MASS TRANSPORT, REDUCE ENERGY DEMAND, AND IMPROVE LONG-TERM SYSTEM TREATMENT STABILITY; AND (4) VALIDATE THE PERFORMANCE OF THE OPTIMIZED EO SYSTEM IN TREATING REAL-WORLD PFAS-CONTAMINATED WATER SAMPLES, SUCH AS GROUNDWATER, LANDFILL LEACHATE, AND ION EXCHANGE BRINE REJECT. TO ACHIEVE THESE OBJECTIVES, THE RESEARCH TEAM WILL CONDUCT SYSTEMATIC EO EXPERIMENTS USING MODEL PFAS COMPOUNDS UNDER CONTROLLED LABORATORY CONDITIONS. ADVANCED ANALYTICAL TECHNIQUES INCLUDING ION CHROMATOGRAPHY, HIGH-RESOLUTION MASS SPECTROMETRY, TOTAL ORGANIC FLUORINE ANALYSIS AND OTHERS WILL BE EMPLOYED TO TRACK PFAS DEGRADATION, QUANTIFY FLUORIDE RELEASE, IDENTIFY TRANSFORMATION PRODUCTS, AND ASSESS DEFLUORINATION EFFICIENCY. THESE DATA WILL BE USED TO CHARACTERIZE DEGRADATION PATHWAYS AND ASSESS TREATMENT EFFICIENCY. COMPLEMENTING THE EXPERIMENTAL STUDIES, COMPUTATIONAL MODELING AND QUANTUM CHEMICAL CALCULATIONS WILL SIMULATE PFAS INTERACTIONS WITH BDD SURFACES, PROVIDING INSIGHT INTO ACTIVATION ENERGIES, REACTIVE INTERMEDIATES, AND RATE-DETERMINING STEPS FOR BOTH DIRECT AND INDIRECT OXIDATION MECHANISMS. MODELING WILL ALSO BE USED TO OPTIMIZE ELECTRODE GEOMETRY AND REACTOR DESIGN, USING FLUID DYNAMICS AND ELECTRIC FIELD SIMULATIONS TO ENHANCE MASS TRANSFER AND REACTIVE SPECIES DISTRIBUTION. BASED ON THESE SIMULATIONS, PROTOTYPE BDD ELECTRODES WITH IMPROVED SURFACE AND ELECTRICAL PROPERTIES WILL BE FABRICATED AND INTEGRATED INTO CUSTOM-BUILT EO CELLS FOR PERFORMANCE TESTING. FOLLOWING LAB-SCALE OPTIMIZATION, THE NEW EO SYSTEMS WILL BE TESTED ON REAL WATER MATRICES WITH COMPLEX CHEMICAL BACKGROUNDS TO ASSESS TREATMENT ROBUSTNESS, MATRIX EFFECTS, AND SYSTEM SCALABILITY. THESE EVALUATIONS WILL PROVIDE A CRITICAL BRIDGE BETWEEN BENCH-SCALE RESEARCH AND FIELD-SCALE IMPLEMENTATION, ENSURING THAT THE DEVELOPED TECHNOLOGIES ARE VIABLE UNDER REALISTIC ENVIRONMENTAL CONDITIONS. THE BROADER IMPACT OF THIS PROJECT LIES IN TRANSLATING FUNDAMENTAL ELECTROCHEMICAL AND MATERIALS SCIENCE INSIGHTS INTO PRACTICAL TECHNOLOGIES FOR PFAS REMEDIATION ACROSS MUNICIPAL, INDUSTRIAL, AND AGRICULTURAL SETTINGS. THE RESEARCH OUTCOMES WILL INFORM STRUCTURE-REACTIVITY RELATIONSHIPS GOVERNING PFAS DEGRADATION ON BDD ELECTRODES, SUPPORT THE RATIONAL DESIGN OF HIGH-EFFICIENCY EO SYSTEMS, AND DEFINE OPERATIONAL STRATEGIES THAT MAXIMIZE PFAS DESTRUCTION WHILE MINIMIZING ENERGY CONSUMPTION AND UNDESIRABLE BYPRODUCT FORMATION. BY ADDRESSING A PRESSING WATER QUALITY CHALLENGE WITH A SCIENTIFICALLY RIGOROUS AND ENGINEERING-FORWARD APPROACH, THIS PROJECT WILL CONTRIBUTE TO THE DEVELOPMENT OF SUSTAINABLE, SCALABLE SOLUTIONS FOR MITIGATING PFAS CONTAMINATION AND PROTECTING PUBLIC HEALTH. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

THIS PROJECT WILL CONSTRUCT AN INTERTIE BETWEEN AN EXISTING IRRIGATION TURNOUT AND THE BELL RECHARGE FACILITY TO ALLOW FOR GROUNDWATER RECHARGE/BANKING AND INCREASED WATER CONVEYANCE FOR IRRIGATION DEMAND BY ACCOMPLISHING THE FOLLOWING OBJECTIVES: 1. ADMINISTRATION 2. PROJECT REPORTING 3. PROJECT DESIGN 4. ENVIRONMENTAL DOCUMENTATION AND REGULATORY COMPLIANCE 5. PERMITS AND APPROVALS 6. PROJECT CONSTRUCTION 7. CONSTRUCTION ADMINISTRATION AND MANAGEMENT

SHF: MEDIUM: COLLABORATIVE RESEARCH: TRANSFER LEARNING IN SOFTWARE ENGINEERING

BAY-DELTA RESTORATION PROGRAM: CALFED WATER USE EFFICIENCY GRANTS

THE OVERALL GOAL OF THE PROJECT IS TO GUARANTEE THE SURVIVAL OF THE SUMATRAN TIGER IN THE BUKIT TIGA PULUH NATIONAL PARK BY STRENGTHENING THE CAPACITY OF THE BUKIT TIGA PULUH NATIONAL PARK (TNBT) AND EMPOWERING LOCAL SCOUTS TO PROTECT AND MONITOR THE SUMATRAN TIGER POPULATION, ITS HABITAT AND ITS PREYS.THE OBJECTIVES OF THE PROPOSED PROJECT ARE:1) IMPLEMENTING AN EFFECTIVE AND EFFICIENT PATROL SYSTEM WITH FOCUS ON JOINT PATROLS BETWEEN PARK RANGERS AND COMMUNITY-BASED SCOUTS IN BUKIT TIGA PULUH NATIONAL PARK2) STRENGTHENING THE CAPACITY OF PATROL TEAMS THROUGH ADVANCED TRAINING AND SMART, AND BUILD SUSTAINABILITY FOR BUKIT TIGA PULUH NATIONAL PARK3) MONITORING OF TIGERS, TIGER PREY SPECIES AND THEIR HABITAT WITH CAMERA TRAPS AND REMOTE SENSING OF FOREST COVERAGE IN BUKIT TIGA PULUH NATIONAL PARK

THE PURPOSE OF THIS PROJECT IS TO CONTRIBUTE TO THE SURVIVAL OF ENDANGERED CHIMPANZEES IN TANZANIA'S GREATER MAHALE ECOSYSTEM AND PROTECT A KEY HABITAT CORRIDOR BY: (1) EQUIPPING AND TRAINING VILLAGE FOREST SCOUTS INCLUDING THE PROVISION OF GPSS, CAMERAS, BINOCULARS, AND FOOTWEAR; (2) INCREASING VILLAGE CAPACITY TO DERIVE A SUSTAINABLE INCOME FROM VILLAGE FORESTS BY AUGMENTING THE NUMBER OF COMMUNITY CONSERVATION BANK (COCOBA) MICRO-FINANCE SYSTEMS, DEVELOPING ALTERNATIVE LIVELIHOODS, IMPLEMENTING A CARBON CREDIT INCOME PROJECT, AND PROVIDING GOVERNANCE TRAINING; (3) CONDUCTING BIODIVERSITY SURVEYS TO BETTER UNDERSTAND CORRIDOR USE BY CHIMPANZEES AND OTHER KEY SPECIES; AND (4) CONDUCTING A SOCIO-ECONOMIC SURVEY TO UNDERSTAND DRIVERS OF HUMAN IN-MIGRATION AND ENCROACHMENT ON CHIMPANZEE HABITAT.

BOTTOM UP NANOWIRING OF PRIMITIVE NEURAL NETWORKS VIA TUBULATION NANOTUBENET

TARGETING PARP INHIBITOR RESISTANCE

CONSERVATION AND MONITORING OF SUMATRAN ELEPHANTS IN BUKIT TIGA PULUH, INDONESIA - 2

LEARNING-BASED DIMENSIONALITY REDUCTION

NICOP - TURBULENCE COMPENSATION FOR ATMOSPHERIC AND UNDERWATER ENVIRONMENTS

NICOP - A WEARABLE AND AUTONOMOUS STRESS AND FATIGUE MONITORING APPROACH FOR PILOTS

ALGAN/GAN HEMT DEVICES ON 200 MM ENGINEERED SUBSTRATES FOR 5G APPLICATIONS

SUPPORT TO TANZANIA WILDLIFE MANAGEMENT AUTHORITY IN THE PROTECTION OF AFRICAN ELEPHANTS

INCREASED SECURITY ALONG THE ZIMBABWEAN-MOZAMBIQUE BORDER IN GONAREZHOU NATIONAL PARK, ZIMBABWE

MULTITARGET-DISPLAY VIRUSLIKE PARTICLE-BASED VACCINE TO COMBAT LYME DISEASE

TAS::57 3600::TAS 'STRUCTURE-PRESERVING MODEL-REDUCTION'

INCREMENTAL FUNDING AND BUDGET PERIOD EXTENSION

BUGGED (BOTTOM-UP GRAPHENE NANORIBBONS FOR NEXT-GENERATION ELECTRONIC DEVICES)

PROJECTED BELIEF NETWORKS FOR CLASSIFICATION OF UNDERWATER ACOUSTIC SIGNALS

HOMELESS ASSISTANCE

THE PURPOSE OF THIS PROJECT IS TO SUPPORT AN ELEPHANT CONSERVATION EFFORT IN ZAMBIAS NSUMBU NATIONAL PARK AND SURROUNDING GAME MANAGEMENT AREAS BY STRENGTHENING ELEPHANT PROTECTION AND BIOLOGICAL MONITORING IN SUPPORT OF ELEPHANT POPULATION GROWTH AND RANGE EXPANSION. NSUMBU NATIONAL PARKS ELEPHANTS ARE GENETICALLY DISTINCT, AND THE LAST ELEPHANTS FOUND ANYWHERE ALONG THE SHORES OF LAKE TANGANYIKA. THIS POPULATION OF APPROXIMATELY 200 INDIVIDUALS CONSTITUTES THE SURVIVING REMNANTS OF A MUCH WIDER HISTORIC ELEPHANT POPULATION THAT ONCE ROAMED THROUGHOUT THE REGION. THIS PROJECT IS INTENDED TO CONSERVE AFRICAN SAVANNA ELEPHANTS AND THEIR HABITAT BY ADDRESSING THE IMPACTS OF POACHING. ACTIVITIES INCLUDE: (1) PROVISIONING ADEQUATE SUPPLIES, INCLUDING, RATIONS, FUEL (AND ASSOCIATED VEHICLE MAINTENANCE), FIRST AID KITS, UNIFORMS, SLEEPING BAGS, AND COMMUNICATIONS EQUIPMENT FOR ANTI-POACHING PATROLS (2) CONDUCTING RANGER REFRESHER TRAININGS TWICE EACH YEAR (3) MAINTAINING DRY SEASON ROAD ACCESS IN THE EASTERN SECTOR OF THE LANDSCAPE AND (4) FACILITATING REGULAR INFORMATION SHARING BETWEEN ZAMBIA AND TANZANIA REGARDING CROSS-BORDER ELEPHANT MOVEMENTS AND ILLEGAL ACTIVITIES.

SBE TWC: SMALL: COLLABORATIVE: POCKET SECURITY - SMARTPHONE CYBERCRIME IN THE WILD

TAS::57 3600::TAS 'MONITORING AT ANY COST' DATED 21 MAR 2017 (THE GRANTEE'S TECHNICAL PROPOSAL) IS HEREBY INCORPORATED BY REFERENCE.

SCHLOSS DAGSTUHL SUPPORT GRANT FOR JUNIOR RESEARCHERS

RECOVERY AND RETURN IMPROVEMENTS TO DISTRICT SPREADING GROUNDS FOR DROUGHT RESILIENCY

TO ANALYZE AND PRODUCE A REPORT OUTLINING HIDDEN COSTS TO EUROPEAN OPERATORS AND GOVERNMENTS FROM USING UNTRUSTED VENDORS FOR 5G NETWORKS.

GENETICALLY ENCODED ACTIVITY SENSORS FOR PHOTOACOUSTIC IMAGING OF THE BRAIN

THE PURPOSE OF THIS PROJECT IS TO CONTINUE DEVELOPING EVALUATING AND TRANSFERRING STATE-OF-THE-ART SOFTWARE ENGINEERING TECHNOLOGIES AND SOFTWARE ASSURANCE METHODS IN SUPPORT OF NASA S OFFICE OF SAFETY AND MISSION ASSURANCE (OSMA) AND TO CONTINUALLY IMPROVE THE SOFTWARE ASSURANCE CAPABILITIES FOR NASA MISSIONS. AS MANY INNOVATIVE SOFTWARE ENGINEERING TECHNOLOGIES EMERGE NASA S INTEREST IN ADOPTING THEM FOR MISSIONS INCREASES IN CORRESPONDENCE. ADDITIONALLY NEW FOCUS AREAS SUCH AS CYBERSECURITY AUTONOMY AND ARTIFICIAL INTELLIGENCE HAVE BECOME MORE RELEVANT FOR NASA MISSIONS. CONSEQUENTLY THIS REQUIRES SOFTWARE ASSURANCE ENGINEERS (SAE) TO ADAPT AND DEVELOP SOFTWARE ASSURANCE METHODS THAT ARE CAPABLE OF SUPPORTING EVALUATING AND ASSURING NASA PROJECTS WITH CONFIDENCE.

TAS::57 3600::TAS 'SMALL-MOLECULE REACTIONS RELEVANT TO THE HYPERSON FLIGHT'

RETHINKING GENERATIVE ADVERSARIAL NETWORKS WITH APPLICATIONS TOWARDS ROBUST MACHINE LEARNING SYSTEMS

ZERO-POWER SENSING FOR UNDERWATER MONITORING

CONSERVATION AND MONITORING OF SUMATRAN ELEPHANTS IN BUKIT TIGAPULUH, INDONESIA.

NOVEL METHODOLOGIES AND IVIVC APPROACHES TO ASSESS BIOEQUIVALENCE OF TOPICAL DRUG

DE-FE0031666: CYBER SECURE SENSOR NETWORK FOR FOSSIL FUEL POWER GENERATION ASSETS MONITORING: NEW AWARD

TAS::57 3600::TAS AERO-THERMO-ELASTIC NONLINEAR REDUCED ORDER MODELING FOR HYPERSONIC AIRFRAMES

R&D, SCIENCE AND ENGINEERING, IN THE AREA OF ELECTRICAL

THE PURPOSE OF THIS PROJECT IS TO INCREASE THE OPERATIONAL EFFICIENCY OF THE RECENTLY CREATED LOMAMI NATIONAL PARK (LNP), DEMOCRATIC REPUBLIC OF CONGO. THE LNP HARBORS SEVERAL ICONIC ENDEMIC SPECIES INCLUDING BONOBO, OKAPI, AND CONGO PEACOCK AS WELL AS A STABLE POPULATION OF FOREST ELEPHANT. THE PROJECT AIMS TO EXTEND WILDLIFE MANAGEMENT INTO THE CURRENT BUFFER ZONE THROUGH ESTABLISHMENT OF COMMUNITY RESERVES WHILE INCREASING COLLABORATION WITH SURROUNDING COMMUNITIES TO ENSURE BETTER PROTECTION FOR THE PARK AS WELL. ACTIVITIES INCLUDE: (1) IMPROVING MANAGEMENT AND MONITORING SYSTEMS WITHIN LNP (2) SUPPORTING COMMUNITIES IN PARTICIPATORY MAPPING OF AND DEVELOPMENT OF MANAGEMENT PLANS FOR COMMUNITY CONCESSIONS IN THE BUFFER ZONE AND (3) CONDUCTING REGULAR MONITORING AND SURVEYS OF KEY WILDLIFE POPULATIONS AND STATUS OF THREATS.

CIRCUIT DYNAMICS UNDERLYING PERCEPTUAL LEARNING IN THE FUNCTIONALLY ORGANIZED VISUAL CORTEX - PROJECT SUMMARY EXPERIENCE SHAPES CORTICAL SENSORY REPRESENTATIONS IN A REMARKABLE MANNER DURING DEVELOPMENT, BUT AFTER MATURATION CAPACITY FOR PLASTICITY BECOMES LIMITED. THE TIGHTLY REGULATED PLASTICITY OF THE MATURE CORTEX ENABLES LEARNING BUT IMPEDES THE BRAIN’S CAPACITY TO REGAIN APPROPRIATE FUNCTION AFTER INJURY, STROKE OR PROLONGED SENSORY LOSS. STUDYING MECHANISMS THAT UNDERLIE PERCEPTUAL LEARNING IN THE ADULT STAGE WILL ADVANCE OUR UNDERSTANDING OF PERCEPTION AND WILL PROVIDE THE FOUNDATION TO DEVELOP NOVEL APPROACHES THAT PROMOTE PLASTICITY IN THE ADULT BRAIN. RECENT STUDIES IN THE TREE SHREW (TUPAIA BELANGERI), A HIGHLY VISUAL MAMMAL THAT SHARES CORTICAL ORGANIZATION FEATURES WITH PRIMATES, SHOW THAT LEARNING A REWARD-BASED ORIENTATION DISCRIMINATION TASK LEADS TO LONG LASTING CHANGES IN EXCITATORY RESPONSES THAT INCREASE DISCRIMINABILITY BETWEEN TASK RELEVANT STIMULI IN THE MATURE PRIMARY VISUAL CORTEX (V1). HOWEVER, WE LACK A CLEAR UNDERSTANDING OF THE UNDERLYING CIRCUIT MECHANISMS THAT ARE RESPONSIBLE FOR THESE CHANGES. I WILL COMBINE MY PREVIOUS EXPERIENCE STUDYING MECHANISMS OF SYNAPTIC PLASTICITY WITH NEW TRAINING FOCUSED ON EXPANDING MY TECHNICAL EXPERTISE IN CUTTING EDGE OPTICAL APPROACHES TO UNCOVER THE MECHANISMS UNDERLYING PERCEPTUAL LEARNING IN THE TREE SHREW. PRELIMINARY DATA SUGGEST THAT A TRANSIENT AND FEATURE SPECIFIC DECREASE IN THE INHIBITORY NETWORK RESPONSE PRECEDES CHANGES IN THE EXCITATORY NEURONAL POPULATION ASSOCIATED WITH ENHANCED PERFORMANCE, SHOWING THAT THE LEARNING PROCESS IN TREE SHREW V1 LAYER 2/3 IS A PRECISE ONE WHERE CIRCUIT ELEMENTS ARE ENGAGED WITH BOTH FEATURE AND TEMPORAL SPECIFICITY. I WILL EMPLOY CHRONIC 2-PHOTON IMAGING IN COMBINATION WITH NOVEL GENETIC ENHANCERS AND PRECISE RNASCOPE TECHNOLOGY TO DETERMINE CHANGES IN THE RESPONSE PROPERTIES OF V1 INHIBITORY NEURAL SUBPOPULATIONS DURING PERCEPTUAL LEARNING (AIM 1). ADDITIONALLY, I WILL DEFINE CHANGES IN THE FUNCTIONAL SYNAPTIC ARCHITECTURE OF EXCITATORY NEURONS THAT UNDERGO LEARNING-RELATED CHANGES (AIM 2) BY APPLYING CALCIUM IMAGING OF DENDRITIC SPINES THROUGH THE LEARNING PROCESS. FINALLY, I WILL ESTABLISH THE SPATIOTEMPORAL RECRUITMENT OF ACETYLCHOLINE RELEASE DURING DISCRIMINATION LEARNING (AIM 3) BY TAKING ADVANTAGE OF A RECENTLY DEVELOPED CHOLINERGIC SENSOR THAT CAN BE IMAGED CHRONICALLY THROUGH LEARNING STAGES. THIS PROJECT CAPITALIZES ON THE FUNCTIONAL ORGANIZATION OF THE TREE SHREW V1 AREA AS A UNIQUE MODEL TO ADDRESS HOW PERCEPTUAL LEARNING IS IMPLEMENTED IN HIGHLY STRUCTURED CORTICAL NETWORKS AKIN TO THOSE FOUND IN THE PRIMATE CORTEX. THE STUDIES WILL TAKE PLACE IN A COLLABORATIVE ENVIRONMENT AT MAX PLANCK FLORIDA INSTITUTE FOR NEUROSCIENCE (MPFI) KNOWN FOR DEVELOPING INNOVATIVE APPROACHES TO ADDRESS FUNDAMENTAL QUESTIONS ABOUT NEURAL CIRCUITS AND HOSTING ONE OF THE FEW TREE SHREW COLONIES IN THE WORLD. COMPLETION OF THESE AIMS AND TRAINING PLAN WILL LEAD TO A COMPREHENSIVE FRAMEWORK DESCRIBING THE PROGRESSION OF LEARNING-RELATED PLASTICITY IN A FUNCTIONALLY STRUCTURED CORTEX UPON WHICH I WILL BUILD AN INDEPENDENT RESEARCH PROGRAM IN THE FUTURE.

EXPERIENCE-DRIVEN DEVELOPMENT OF RELIABLE STIMULUS REPRESENTATIONS IN DYNAMIC CORTICAL NETWORKS - PROJECT SUMMARY/ABSTRACT THE ONSET OF SENSORY EXPERIENCE TRANSFORMS IMMATURE CORTICAL NETWORKS INTO MATURE REPRESENTATIONS THAT SUPPORT RELIABLE DISCRIMINATION OF BEHAVIORALLY RELEVANT STIMULI. CORTICAL RESPONSES ENCODE STIMULI BY THE PROFILE OF ACTIVITY ACROSS A POPULATION OF NEURONS (POPULATION RESPONSE). TO PROVIDE STIMULUS INFORMATION, POPULATION RESPONSES MUST BE DIFFERENT ACROSS STIMULI AND ALSO RELIABLE ACROSS PRESENTATIONS OF THE SAME STIMULUS. NOVEL TECHNIQUES THAT MEASURE ACTIVITY CHRONICALLY ACROSS LARGE NEURONAL POPULATIONS WITH SINGLE-TRIAL RESOLUTION IN DEVELOPING ANIMALS WILL NOW HELP US DEFINE HOW RELIABLE POPULATION RESPONSES MATURE WITH EXPERIENCE. THIS QUESTION IS FUNDAMENTAL AS A RELIABLE TRANSMISSION OF INFORMATION IS CRITICAL FOR PERCEPTION AND COGNITION. THE CANDIDATE’S PREVIOUS WORK SHOWS THAT A DEVELOPMENTAL ALIGNMENT BETWEEN THE STRUCTURE OF FEEDFORWARD INPUTS AND RECURRENT CONNECTIVITY IN SUPERFICIAL LAYERS 2/3 OF THE FERRET PRIMARY VISUAL CORTEX (V1) CONTRIBUTES TO THE EMERGENCE OF A RELIABLE REPRESENTATION OF EDGE ORIENTATION FOLLOWING THE ONSET OF VISUAL EXPERIENCE. DURING THE K99 PERIOD, THE CANDIDATE WILL EXPAND ON THESE INITIAL FINDINGS ADDRESSING TWO KEY QUESTIONS. FIRST, THE CANDIDATE WILL USE NOVEL METHODS HE HAS DESIGNED FOR 3-DIMENSIONAL ELECTRODE ARRAY RECORDINGS IN DEVELOPING FERRETS TO RESOLVE THE SEQUENCE OF CHANGES IN RESPONSE PROPERTIES AND CONNECTIVITY ACROSS LAYERS 2/3 AND LAYER 4, THE MAIN SOURCE OF FEEDFORWARD INPUTS TO LAYERS 2/3, THAT RESULT IN FEEDFORWARD-RECURRENT ALIGNMENT AFTER EXPERIENCE. SECOND, THE CANDIDATE WILL USE CHRONIC TWO-PHOTON IMAGING TO RESOLVE IF THE MATURATION OF INHIBITORY RESPONSES IN LAYERS 2/3 CONTRIBUTES TO INCREASE POPULATION RESPONSE RELIABILITY IN THIS LAYER. TO ACHIEVE THESE GOALS, THE CANDIDATE WILL BE MENTORED BY DR. DAVID FITZPATRICK, A WORLD-RENOWNED AUTHORITY ON VISION DEVELOPMENT AND AN EXPERT IN IMAGING TECHNIQUES. THROUGH COLLABORATIONS WITH DR. TING AT THE ALLEN INSTITUTE AND DR. YASUDA AT THE MAX PLANCK FLORIDA INSTITUTE FOR NEUROSCIENCE (MPFI), THE CANDIDATE WILL DEVELOP NOVEL GENETIC CONSTRUCTS TO DISRUPT ACTIVITY- DEPENDENT PLASTICITY IN SPECIFIC CORTICAL LAYERS OR NEURONAL TYPES IN FERRET V1. AS AN INDEPENDENT INVESTIGATOR, THE CANDIDATE WILL USE THESE TOOLS TO INVESTIGATE HOW SENSORY EXPERIENCE REFINES CORTICAL CIRCUITS TO PRODUCE A MATURE REPRESENTATION AT THE NEURONAL POPULATION LEVEL. AS A FIRST STEP TOWARDS THIS NOVEL SCIENTIFIC DIRECTION, THE CANDIDATE WILL CONSULT WITH DR. INAGAKI AT MPFI TO RESOLVE WHETHER EXPERIENCE-DRIVEN SYNAPTIC PLASTICITY IN LAYER 4 IS NECESSARY FOR THE EMERGENCE OF RELIABLE POPULATION RESPONSES IN LAYERS 2/3. THIS METHODOLOGICAL APPROACH DIFFERENTIATES THE CANDIDATE’S RESEARCH FROM DR. FITZPATRICK’S, WHICH FOCUSES ON SINGLE-CELL SYNAPTIC ARCHITECTURE AND RESPONSE PROPERTIES. TO ACQUIRE THE PROFESSIONAL SKILLS ESSENTIAL FOR A SUCCESSFUL TRANSITION TO INDEPENDENCE, THE CANDIDATE WILL CONSULT WITH DR. NAMBOODIRI, WHO WILL GUIDE THE CANDIDATE’S PLAN FOR TRAINING IN PROFESSIONAL DEVELOPMENT, FOSTERING HIS SUCCESS AS A YOUNG INVESTIGATOR. THROUGHOUT THE PROJECT PERIOD, THE MENTOR, COLLABORATORS, AND CONSULTANTS WILL WORK TOGETHER AS AN ADVISORY COMMITTEE TO GUIDE THE CANDIDATE AS HE IMPROVES HIS RESEARCH, SECURES AN INDEPENDENT RESEARCH POSITION, AND ESTABLISHES A SUCCESSFUL LAB AT HIS NEW INSTITUTION.

CPS: FRONTIER: COLLABORATIVE RESEARCH: COMPOSITIONAL, APPROXIMATE, AND QUANTITATIVE REASONING FOR MEDICAL CYBER-PHYSICAL SYSTEMS

PRIVACY-PRESERVING FOUNDATION FOR ONLINE PERSONAL IDENTITY

ASSISTANCE TO FIREFIGHTERS GRANT

INPUT-SPECIFIC IMAGING AND MANIPULATION OF SYNAPTIC PLASTICITY UNDERLYING SOCIAL MEMORY

THE PURPOSE OF THIS PROJECT IS TO SUPPORT AN ELEPHANT CONSERVATION EFFORT IN NSUMBU NATIONAL PARK AND SURROUNDING GAME MANAGEMENT AREAS BY STRENGTHENING ELEPHANT PROTECTION AND BIOLOGICAL MONITORING. NSUMBU NATIONAL PARK'S ELEPHANTS ARE GENETICALLY DISTINCT AND THE LAST ELEPHANTS FOUND ANYWHERE ALONG THE SHORES OF LAKE TANGANYIKA. THIS POPULATION OF APPROXIMATELY 150 INDIVIDUALS CONSTITUTES THE SURVIVING REMNANTS OF A MUCH WIDER HISTORIC ELEPHANT POPULATION THAT ONCE ROAMED THROUGHOUT THE REGION. THIS PROJECT IS INTENDED TO CONSERVE AFRICAN SAVANNA ELEPHANTS AND THEIR HABITAT BY ADDRESSING THE IMPACTS OF POACHING. SPECIFIC ACTIVITIES INCLUDE: (1) PROVISIONING ADEQUATE SUPPLIES, INCLUDING VEHICLE PROCUREMENT, FUEL, RATIONS, AND COMMUNICATIONS EQUIPMENT FOR ANTI-POACHING PATROLS.

PRINCIPLES OF PRESYNAPTIC NETWORKS FOR SINGLE LAYER 2/3 NEURONS IN FERRET VISUAL CORTEX

DROUGHT CONTINGENCY PLAN FOR THE POSO CREEK INTEGRATED REGIONAL WATER MANAGEMENT GROUP

LAW ENFORCEMENT OPERATIONAL SUPPORT FOR ELEPHANT SECURITY IN THE NSUMBU-TANGANYIKA ECOSYSTEM

NEURONAL POPULATION CONTRIBUTIONS TO FINE FEATURE DISCRIMINATION LEARNING AND PERFORMANCE IN THE COLUMNAR ARCHITECTURE OF VISUAL CORTEX

IMPROVING THE PERFORMANCE OF THE FINITE-FAULT RUPTURE DETECTOR (FINDER) ALGORITHM IN THE US WEST COAST SHAKEALERT SYSTEM

TAS::57 3600::TAS "ULTRACOLD POLAR MOLECULES: NEW PHASES OF MATTER FOR QUANTUM INFORMATION AND QUANTUM CONTROL."

LOCAL CONTROL OF THE ACTION POTENTIAL IN AXONS

NOVEL MTORC1 INHIBITORS TO TREAT TSC

ADVANCED CONSTITUENTS AND PROCESSING FOR ROBUST CMCS

THE BIPARTISAN INFRASTRUCTURE LAW (BIL), SECTION 24112 CREATED THE SAFE STREETS AND ROADS FOR ALL (SS4A) GRANT PROGRAM TO SUPPORT LOCAL INITIATIVES TO PREVENT DEATHS AND SERIOUS INJURIES ON ROADS AND STREETS. PLANNING AND DEMONSTRATION GRANTS PROVIDE FEDERAL FUNDS TO ELIGIBLE APPLICANTS TO DEVELOP OR COMPLETE A COMPREHENSIVE SAFETY ACTION PLAN, AND/OR TO FUND SUPPLEMENTAL PLANNING, AND/OR DEMONSTRATION ACTIVITIES TO SUPPORT OR ENHANCE AN EXISTING ACTION PLAN. THE PROJECT CONTAINED HEREIN PROVIDES SS4A GRANT FUNDS TO DEVELOP, SUPPORT, OR ENHANCE AN ACTION PLAN AND/OR CONDUCT SUPPLEMENTAL PLANNING AND/OR DEMONSTRATION ACTIVITIES IN SUPPORT OF AN ACTION PLAN. IT IS PRESENTED TO CITY OF SHAFTER, CA FOR THE PROJECT 'CITY OF SHAFTER TRAFFIC SAFETY ACTION PLAN'; UEI-#RP8KZKM1YJB8.

OPERATIONAL VEHICLES AND AERIAL SUPPORT FOR ELEPHANT (LOXODONTA AFRICANA) CONSERVATION IN NORTH LUAN

IMPLEMENTATION OF RIVER INFORMATION SERVICES ON THE US INLAND WATERWAY NETWORK

THALAMOCORTICAL MECHANISMS IN PRIMARY VISUAL CORTEX

PROJECT "HUMAN RIGHTS PUBLICATIONS: 'IRAN HUMAN RIGHTS REPORT' AND OTHER PUBLICATIONS"

RESEARCH TO ADVANCE THE DEVELOPMENT OF RIVER INFORMATION SERVICES (RIS) TECHNOLOGIES

FALL RIVER POLICE DEPARTMENT CRIME LAB

NICOP - BASIC ICEBREAKING STUDY

ELUCIDATING THE MOLECULAR MECHANISMS OF JUN/FOS TRANSCRIPTION FACTOR FUNCTION IN CARDIAC REGENERATION AND PROTECTION

EMERG SHELTER GRANTS

EMERG SHELTER GRANTS

IDENTIFYING BIOMOLECULAR NETWORKS DRIVING METABOLIC TRAIT VARIATION

THE FALL RIVER POLICE DEPARTMENT PROPOSES TO USE FUNDING FROM THE COPS FY23 DE-ESCALATION TRAINING GRANT TO PURCHASE AN APEX OFFICER PRO TRAINING SIMULATOR, WHICH IS A STATE-OF-THE-ART TRAINING SYSTEM THAT USES VIRTUAL REALITY TO DELIVER IMMERSIVE, INTERACTIVE TRAINING ON DE-ESCALATION, USE OF FORCE, CRISIS INTERVENTION, IMPLICIT BIAS, AND MUCH MORE. THIS PIECE OF EQUIPMENT WILL BECOME A MANDATORY PART OF THE TRAINING EXPERIENCE FOR ALL FRPD OFFICERS AS THE NEED FOR DE-ESCALATION AND USE OF FORCE TRAINING BECOMES INCREASINGLY PRESSING ON A NATIONAL LEVEL. IN ADDITION, WHILE NO MEMORANDA OF UNDERSTANDING ARE CURRENTLY IN PLACE, THE FRPD IS OPEN TO PARTNERING WITH OTHER DEPARTMENTS ACROSS SOUTH COAST NEW ENGLAND IN ORDER TO SHARE THIS PROMISING TECHNOLOGY AND STRENGTHEN THE COMMUNITY POLICING CAPACITY OF THE REGION OVERALL.

NICOP - CONTRIBUTION OF POLAR NANO-REGIONS TO THE LARGE PIEZOELECTRIC RESPONSE IN PB-BASED RELAXOR FERROELECTRICS

THE RHINOCEROS AND TIGER CONSERVATION FUND (RTCF) IS SOLICITING PROPOSALS FOR THE CONSERVATION OF AFRICAN RHINOCEROSES. IN RESPONSE TO THE ALARMING DECLINE OF RHINO AND TIGER POPULATIONS, THE US CONGRESS PASSED THE RHINOCEROS AND TIGER CONSERVATION ACT IN 1994. THE ACT PROVIDES FOR THE ESTABLISHMENT OF THE RHINO TIGER CONSERVATION FUND TO BE ADMINISTERED BY THE U.S. FISH & WILDLIFE SERVICE (USFWS) TO PROVIDE FINANCIAL ASSISTANCE TO SUPPORT PROJECTS THAT WORK TO CONSERVE POPULATIONS OF RHINOS AND TIGERS IN THE WILD. PROPOSALS FOR AFRICA AND FOR ASIA ARE HANDLED THROUGH DIFFERENT PROGRAM OFFICES. THIS DOCUMENT REFERS SPECIFICALLY TO THE AFRICA PROGRAM. THIS FUNDING OPPORTUNITY ALIGNS WITH THE USFWS MISSION AND THE SECRETARY⿿S PRIORITIES, INCLUDING: 1. CREATE A CONSERVATION STEWARDSHIP LEGACY, SECOND ONLY TO TEDDY ROOSEVELT 2. SUSTAINABLY DEVELOP OUR ENERGY & NATURAL RESOURCES 3. RESTORE TRUST & BE A GOOD NEIGHBOR 4. ENSURE TRIBAL SOVEREIGNTY MEANS SOMETHING 7. STRIKE A REGULATORY BALANCE 10. ACHIEVING OUR GOALS, LEADING OUR TEAM FORWARD THE U.S. FISH & WILDLIFE SERVICE⿿S AFRICAN RHINO PROGRAM SUPPORTS PROJECTS THAT PROMOTE CONSERVATION THROUGH: ⿢ ENHANCED PROTECTION OF AT-RISK RHINOCEROS POPULATIONS; ⿢ PROTECTED AREA/RESERVE MANAGEMENT IN IMPORTANT RHINOCEROS RANGE; ⿢ VETERINARY CARE FOR WILD POPULATIONS; ⿢ HABITAT CONSERVATION AND MANAGEMENT; ⿢ REINTRODUCTION TO FORMER RANGE; ⿢ RESTORATION OF HABITAT; ⿢ WILDLIFE INSPECTION, LAW ENFORCEMENT, AND FORENSICS SKILLS; ⿢ CONSERVATION EDUCATION AND COMMUNITY OUTREACH; ⿢ STRENGTHENING LOCAL CAPACITY TO IMPLEMENT CONSERVATION PROGRAMS; ⿢ APPLIED RESEARCH ON RHINOCEROS POPULATIONS AND THEIR HABITATS, INCLUDING SURVEYS AND MONITORING; ⿢ DEVELOPMENT AND EXECUTION OF RHINOCEROS CONSERVATION MANAGEMENT PLANS; AND ⿢ COMPLIANCE WITH APPLICABLE TREATIES AND LAWS THAT PROHIBIT OR REGULATE THE TAKING OR TRADE OF RHINOCEROS OR REGULATE THE USE AND MANAGEMENT OF THEIR HABITAT; ⿢ REDUCING DEMAND FOR ILLEGAL RHINO PARTS AND PRODUCTS AND FOR LIVE ANIMALS IN CONSUMER COUNTRIES; ⿢ COMBATTING TRAFFICKING OF ILLEGAL RHINO PARTS, PRODUCTS AND LIVE ANIMALS. PROPOSED PROJECT WORK SHOULD OCCUR WITHIN RHINOCEROS RANGE, OR, IF WORK IS TO BE CONDUCTED OUTSIDE OF THE RANGE, THE PROPOSAL SHOULD SHOW CLEAR RELEVANCE TO RHINOCEROS CONSERVATION. PROPOSALS MUST IDENTIFY IMMEDIATE THREATS TO RHINO SURVIVAL AND SUPPORT DIRECT CONSERVATION ACTIVITIES TO ELIMINATE OR REDUCE THOSE THREATS. IF THE PROJECT INCLUDES RESEARCH, THE APPLICANT MUST PROVIDE A CONVINCING ARGUMENT THAT THE RESEARCH ADDRESSES PRIORITY THREATS AND THAT THE RESULTS ARE LIKELY TO RESULT IN MANAGEMENT ACTIONS. PRIORITY WILL BE GIVEN TO PROJECTS INVOLVING INDIGENOUS SUBSPECIES WITHIN NATURAL RANGE. EX SITU POPULATIONS ARE NOT ELIGIBLE. FUNDING DECISIONS WILL ALSO TAKE THE DEGREE OF ENDANGERMENT OF THE TAXON INTO ACCOUNT, WITH MORE FUNDING DIRECTED TO MORE IMPERILED SUBSPECIES. FUNDING DECISIONS WILL ALSO TAKE IN THE IMPORTANCE OF THE PARTICULAR POPULATION TO THE SURVIVAL OF THE SUBSPECIES.

SUPPORT TO TANZANIA NATIONAL PARKS IN THE PROTECTION OF THEIR BLACK RHINOCEROS POPULATION IN SERENGETI NATIONAL PARK AND ADJOINING AREAS, TANZANIA

SUPPORT FOR LAW ENFORCEMENT ACTIVITIES AND PROTECTION OF ELEPHANT IN NORTH LUANGWA NATIONAL PARK, ZA

THE GDPRD OFFERS A NEUTRAL CONVENING SPACE IN WHICH MEMBERS ARE ABLE TO WORK TOGETHER ON ISSUES OF COMMON INTEREST, SHARED EXPERIENCE AND EXPERTISE, AND TO NETWORK INFORMALLY WITH OTHER AGRICULTURE AND RURAL DEVELOPMENT PROFESSIONALS.

SPATIOTEMPORAL DYNAMICS OF ISOZYME-SPECIFIC PKC ACTIVITY DURING PLASTICITY

R&D, SCIENCE AND ENGINEERING, IN THE AREA OF PHYSICS

THE RHINOCEROS AND TIGER CONSERVATION FUND (RTCF) IS SOLICITING PROPOSALS FOR THE CONSERVATION OF AFRICAN RHINOCEROSES. IN RESPONSE TO THE ALARMING DECLINE OF RHINO AND TIGER POPULATIONS, THE US CONGRESS PASSED THE RHINOCEROS AND TIGER CONSERVATION ACT IN 1994. THE ACT PROVIDES FOR THE ESTABLISHMENT OF THE RHINO TIGER CONSERVATION FUND TO BE ADMINISTERED BY THE U.S. FISH & WILDLIFE SERVICE (USFWS) TO PROVIDE FINANCIAL ASSISTANCE TO SUPPORT PROJECTS THAT WORK TO CONSERVE POPULATIONS OF RHINOS AND TIGERS IN THE WILD. PROPOSALS FOR AFRICA AND FOR ASIA ARE HANDLED THROUGH DIFFERENT PROGRAM OFFICES. THIS DOCUMENT REFERS SPECIFICALLY TO THE AFRICA PROGRAM. THIS FUNDING OPPORTUNITY ALIGNS WITH THE USFWS MISSION AND THE SECRETARY⿿S PRIORITIES, INCLUDING: 1. CREATE A CONSERVATION STEWARDSHIP LEGACY, SECOND ONLY TO TEDDY ROOSEVELT 2. SUSTAINABLY DEVELOP OUR ENERGY & NATURAL RESOURCES 3. RESTORE TRUST & BE A GOOD NEIGHBOR 4. ENSURE TRIBAL SOVEREIGNTY MEANS SOMETHING 7. STRIKE A REGULATORY BALANCE 10. ACHIEVING OUR GOALS, LEADING OUR TEAM FORWARD THE U.S. FISH & WILDLIFE SERVICE⿿S AFRICAN RHINO PROGRAM SUPPORTS PROJECTS THAT PROMOTE CONSERVATION THROUGH: ⿢ ENHANCED PROTECTION OF AT-RISK RHINOCEROS POPULATIONS; ⿢ PROTECTED AREA/RESERVE MANAGEMENT IN IMPORTANT RHINOCEROS RANGE; ⿢ VETERINARY CARE FOR WILD POPULATIONS; ⿢ HABITAT CONSERVATION AND MANAGEMENT; ⿢ REINTRODUCTION TO FORMER RANGE; ⿢ RESTORATION OF HABITAT; ⿢ WILDLIFE INSPECTION, LAW ENFORCEMENT, AND FORENSICS SKILLS; ⿢ CONSERVATION EDUCATION AND COMMUNITY OUTREACH; ⿢ STRENGTHENING LOCAL CAPACITY TO IMPLEMENT CONSERVATION PROGRAMS; ⿢ APPLIED RESEARCH ON RHINOCEROS POPULATIONS AND THEIR HABITATS, INCLUDING SURVEYS AND MONITORING; ⿢ DEVELOPMENT AND EXECUTION OF RHINOCEROS CONSERVATION MANAGEMENT PLANS; AND ⿢ COMPLIANCE WITH APPLICABLE TREATIES AND LAWS THAT PROHIBIT OR REGULATE THE TAKING OR TRADE OF RHINOCEROS OR REGULATE THE USE AND MANAGEMENT OF THEIR HABITAT; ⿢ REDUCING DEMAND FOR ILLEGAL RHINO PARTS AND PRODUCTS AND FOR LIVE ANIMALS IN CONSUMER COUNTRIES; ⿢ COMBATTING TRAFFICKING OF ILLEGAL RHINO PARTS, PRODUCTS AND LIVE ANIMALS. PROPOSED PROJECT WORK SHOULD OCCUR WITHIN RHINOCEROS RANGE, OR, IF WORK IS TO BE CONDUCTED OUTSIDE OF THE RANGE, THE PROPOSAL SHOULD SHOW CLEAR RELEVANCE TO RHINOCEROS CONSERVATION. PROPOSALS MUST IDENTIFY IMMEDIATE THREATS TO RHINO SURVIVAL AND SUPPORT DIRECT CONSERVATION ACTIVITIES TO ELIMINATE OR REDUCE THOSE THREATS. IF THE PROJECT INCLUDES RESEARCH, THE APPLICANT MUST PROVIDE A CONVINCING ARGUMENT THAT THE RESEARCH ADDRESSES PRIORITY THREATS AND THAT THE RESULTS ARE LIKELY TO RESULT IN MANAGEMENT ACTIONS. PRIORITY WILL BE GIVEN TO PROJECTS INVOLVING INDIGENOUS SUBSPECIES WITHIN NATURAL RANGE. EX SITU POPULATIONS ARE NOT ELIGIBLE. FUNDING DECISIONS WILL ALSO TAKE THE DEGREE OF ENDANGERMENT OF THE TAXON INTO ACCOUNT, WITH MORE FUNDING DIRECTED TO MORE IMPERILED SUBSPECIES. FUNDING DECISIONS WILL ALSO TAKE IN THE IMPORTANCE OF THE PARTICULAR POPULATION TO THE SURVIVAL OF THE SUBSPECIES.

SOUTH AMERICA REGIONAL PROGRAM

IN PARTNERSHIP WITH THE MAX PLANCK INSTITUTE FOR EVOLUTIONARY ANTHROPOLOGY. THE PURPOSE OF THIS 1-YEAR PROJECT IS TO USE RESEARCH AND CAPACITY BUILDING TO SUPPORT TOURISM AS A CONSERVATION STRATEGY FOR CRITICALLY ENDANGERED WESTERN GORILLAS IN LOANGO NATIONAL PARK, GABON. ACTIVITIES INCLUDE: 1) MONITORING THE IMPACT OF TOURISM ON A HABITUATED GORILLA GROUP AND ON NON-HABITUATED GORILLAS; 2) CONTINUING HABITUATION OF A SECOND GORILLA GROUP; 3) CONDUCTING LONG-TERM GORILLA BEHAVIORAL ECOLOGY RESEARCH; 4) COORDINATING WITH THE GABONESE WILDLIFE AUTHORITY (ANPN) ON MANAGEMENT, SURVEILLANCE FOR ILLEGAL ACTIVITIES, AND DEVELOPMENT OF EDUCATIONAL MATERIALS FOR TOURISM; AND 5) STRENGTHENING NATIONAL CAPACITY FOR SCIENCE-BASED CONSERVATION AND ADAPTIVE MANAGEMENT BY TRAINING GABONESE STAFF.

GREAT APE CONSERVATION FUND 2017

CONSERVATION, RESEARCH AND TOURISM OF CRITICALLY ENDANGERED WESTERN GORILLAS IN LOANGO NATIONAL PARK, GABON

SECURING THE GREATER NORTH LUANGWA LANDSCAPE FOR THE PROTECTION OF BLACK RHINOS (DICEROS BICORNIS MINOR) IN NORTH LUANGWA NATIONAL PARK, ZAMBIA

FY2018 GREAT APE CONSERVATION FUND

ASSISTANCE TO FIREFIGHTERS GRANTS

VALIDATION OF THE IMPLICIT UNSTRUCTURED MODULE OF THE WAVEWATCH3 (WW3)

CONSERVING PRIORITY SPECIES THREATENED BY THE ILLEGAL TRADE TO COMPLEMENT AND FACILITATE EXISTING EFFORTS, USFWS HAS ISSUED THIS NOTICE OF FUNDING OPPORTUNITY TO PROVIDE FINANCIAL ASSISTANCE TO PROJECTS THAT ADDRESS THE ILLEGAL TRADE AND TRAFFICKING OF PRIORITY SPECIES. WILDLIFE TRAFFICKING IS DEFINED IN THE AS THE POACHING OR OTHER TAKING OF PROTECTED OR MANAGED SPECIES AND THE ILLEGAL TRADE IN WILDLIFE AND THEIR RELATED PARTS AND PRODUCTS. FOR THE PURPOSES OF THIS FUNDING OPPORTUNITY, THE TERM ⿿WILDLIFE INCLUDES TERRESTRIAL AND AQUATIC ANIMAL SPECIES AND PLANT SPECIES SUBJECT TO ILLEGAL TRADE. PRIORITY WILL BE GIVEN TO PROPOSALS FOCUSED ON: ⿢SPECIES WHOSE CONSERVATION STATUS⿿ HAS BEEN CATEGORIZED AS THREATENED (INCLUDING VULNERABLE, ENDANGERED, AND ⿿CRITICALLY ENDANGERED) BY THE INTERNATIONAL UNION FOR THE CONSERVATION OF NATURE (IUCN) RED LIST; DESIGNATED AS ⿿THREATENED OR ENDANGERED UNDER THE ENDANGERED SPECIES ACT (ESA, 50CFR17); AND/OR LISTED IN APPENDIX I OF THE CONVENTION ON THE INTERNATIONAL TRADE IN ENDANGERED SPECIES OF WILD FAUNA AND FLORA (CITES). PROPOSALS FOR SPECIES LISTED IN APPENDIX II CITES AND/OR THOSE THAT HAVE YET TO BE LISTED BUT WHOSE CONSERVATION STATUSES ARE GREATLY THREATENED BY ILLEGAL TRADE WILL ALSO BE CONSIDERED. ⿢SPECIES OF INTEREST TO THE USFWS THAT ARE IMMEDIATELY THREATENED BY THE ILLEGAL TRADE INCLUDING AFRICAN GREY PARROTS (PSITTACUS ERITHACUS), PANGOLINS (MANIS SPP. [PHATAGINUS SPP., AND SMUTSIA SPP.]), LIONS (PANTHERA LEO), JAGUARS (PANTHERA ONCA), HIPPOS (HIPPOPOTAMUS AMPHIBIOUS), AND GIRAFFES (GIRAFFA CAMELOPARDALIS). INELIGIBLE SPECIES: SPECIES THAT ARE ELIGIBLE FOR FUNDING UNDER THE USFWS INTERNATIONAL AFFAIRS MULTINATIONAL SPECIES CONSERVATION FUNDS VIA THE AFRICAN ELEPHANT, ASIAN ELEPHANT, RHINOCEROS AND TIGER, GREAT APE, AND MARINE TURTLE CONSERVATION ACTS, WILL BE CONSIDERED INELIGIBLE FOR THIS NOTICE OF FUNDING OPPORTUNITY. APPLICANTS CAN REVIEW ALL FUNDING OPPORTUNITIES ON THE USFWS INTERNATIONAL AFFAIRS HOW TO APPLY PAGE. PROPOSALS MAY ONLY BE SUBMITTED TO ONE PROGRAM EACH FISCAL YEAR; THEREFORE PROPOSALS THAT HAVE ALREADY BEEN SUBMITTED TO ANOTHER PROGRAM (I.E., DUPLICATE PROPOSALS) WILL BE DISQUALIFIED FROM THIS FUNDING OPPORTUNITY.

FUND THE IMPLEMENTATION OF VARIOUS PD PROGRAMS IN CYS 2024 AND 2025.

RESEARCH AS A COMPONENT OF TOURISM DEVELOPMENT FOR WESTERN GORILLAS IN LOANGO NATIONAL PARK, GABON

VALIDATION OF THE IMPLICIT UNSTRUCTURED MODULE OF THE WAVEWATCH3 (WW3) MODELING SYSTEM

THE PURPOSE OF THIS ACTIVITY IS TO REDUCE/MITIGATE HUMAN-WILDLIFE CONFLICTS WITH THE GOAL OF CREATING AWARENESS ON WILDLIFE CONSERVATION AND METHODS TO PREVENT CONTINUOUS RAIDING OF FARMS BY FOREST ELEPHANTS AND OTHER WILDLIFE.

ENSURING THE LONG-ERM CONSERVATION OF TONGO'S CHIMPANZEES BY DEVELOPING TOURISM, EDUCATION AND COMMUNITY OUTREACH PROGRAMS

MESOSCALE MECHANICS OF REACTIVE MATERIALS FOR ENHANCED TARGET EFFECTS

R&D, SCIENCE AND ENGINEERING, IN THE ARE OF PHYSICS, QUANTUM ACCELERATOR

PLASMA ACTIVATED BIOCHAR FOR HIGH-EFFICIENCY CAPACITIVE DESALINATION

""CONSERVATION, RESEARCH AND TOURISM OF WESTERN GORILLAS

FY 2011 PORT SECURITY GRANT PROGRAM