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Source: IRS e-Filed Form 990 (from the IRS e-File system), Tax Year 2023
Total Revenue
▼$35.4M
Program Spending
87%
of total expenses go to program services
Total Contributions
$8.7M
Total Expenses
▼$26.5M
Total Assets
$541.3M
Total Liabilities
▼$45.2M
Net Assets
$496.1M
Officer Compensation
→N/A
Other Salaries
$7.4M
Investment Income
$10.2M
Fundraising
▼N/A
Tax Year 2023 · Source: IRS Form 990, Schedule I (Grants and Other Assistance)
Total grants awarded: $239.1K
| Recipient | Location | Amount | Type | Purpose |
|---|---|---|---|---|
HARVARD UNIVERSITY | CAMBRIDGE, MA | $239.1K | Cash | SCHOLARSHIPS |
| Total | $239.1K | |||
HARVARD UNIVERSITY
CAMBRIDGE, MA
$239.1K
Source: USAspending.gov · Searched by organization name
Total Federal Funding
$14M
Awards Found
19
| Awarding Agency | Description | Amount | Fiscal Year | Period |
|---|---|---|---|---|
| Department of Education | U.S. DEPARTMENT OF EDUCATIONCARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND - IHES | $4.9M | FY2020 | May 2020 – Jan 2022 |
| Department of Education | U.S. DEPARTMENT OF EDUCATION CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND - IHES | $3.9M | FY2020 | Apr 2020 – Jan 2022 |
| Department of Education | EMERGENCY MANAGEMENT FOR HIGHER EDUCATION | $512.1K | FY2011 | Oct 2010 – Sep 2012 |
| National Science Foundation | BRC-BIO: ANALYZING THE ROLE OF DROSOPHILA VARIANT POLYCOMB REPRESSIVE COMPLEXES IN DEVELOPMENTAL GENE TRANSCRIPTION -MULTICELLULAR ORGANISMS ARE COMPOSED OF INDIVIDUAL CELLS THAT FUNCTION DISTINCTLY, DUE TO THE REGULATION OF GENE EXPRESSION DURING DEVELOPMENT. DEVELOPMENTAL GENE REGULATION IS LARGELY MADE POSSIBLE BY MANY PROTEIN COMPLEXES THAT TURN GENES ON OR OFF AT APPROPRIATE DEVELOPMENTAL WINDOWS. AN IMPORTANT EXAMPLE IS THE POLYCOMB REPRESSIVE COMPLEX, WHICH TURNS OFF A SPECIFIC SET OF DEVELOPMENTAL GENES. HOW THIS COMPLEX SELECTS THE CORRECT GENES TO SILENCE DURING EARLY DEVELOPMENT IS STILL UNKNOWN. THIS PROJECT WILL UTILIZE THE FRUIT FLY AS MODEL ORGANISM TO STUDY THE ROLE OF THIS SILENCING COMPLEX IN ORCHESTRATING DEVELOPMENTAL GENE EXPRESSION. DISCOVERING THE MECHANISM BY WHICH POLYCOMB REPRESSIVE COMPLEXES SILENCE GENES IN THE FRUIT FLY WILL INFORM OUR UNDERSTANDING OF DEVELOPMENT IN MAMMALS. ANOTHER SIGNIFICANT GOAL OF THIS PROJECT IS TO INCREASE THE PARTICIPATION OF PERSONS TRADITIONALLY EXCLUDED BECAUSE OF THEIR ETHNICITY OR RACE (PEERS) IN UNDERGRADUATE RESEARCH EXPERIENCES AT EMMANUEL COLLEGE. STUDENT RESEARCHERS WILL USE GENETIC, MOLECULAR, AND BIOCHEMICAL TECHNIQUES TO ADDRESS THE AIMS OF THIS PROJECT. COLLABORATIONS WITH RESEARCHERS FROM HARVARD MEDICAL SCHOOL AND BRANDEIS UNIVERSITY WILL FACILITATE ENGAGEMENT OF PEER UNDERGRADUATE STUDENTS WITH THE BROADER SCIENTIFIC COMMUNITY. THE GOAL IS TO INSPIRE LARGER NUMBERS OF PEER STUDENTS TO PURSUE CAREERS IN STEM. MULTICELLULAR DEVELOPMENT IS GOVERNED BY THE DEPLOYMENT OF CELL-TYPE SPECIFIC TRANSCRIPTIONAL PROGRAMMING, IN WHICH A SINGLE GENOME IS UTILIZED DISTINCTLY OVER TIME AND SPACE AS CELLS MULTIPLY AND SPECIALIZE. THIS PHENOMENON IS ACHIEVED BY THE PRECISE COORDINATION OF GENE EXPRESSION THAT INITIATES THE DIFFERENTIATION OF THE DIFFERENT CELL TYPES OF AN ORGANISM. CHROMATIN REGULATORY FACTORS HAVE BEEN FOUND TO BE ESSENTIAL FOR REGULATION OF DEVELOPMENTAL TRANSCRIPTIONAL PROGRAMMING HOWEVER THE MECHANISM BEHIND HOW THESE FACTORS COORDINATE GENE EXPRESSION DURING EMBRYONIC DEVELOPMENT REMAINS UNCLEAR. ONE HIGHLY CONSERVED CHROMATIN REGULATORY SYSTEM THAT PLAYS A CENTRAL ROLE IN DEVELOPMENTAL PATTERNING AND CELL DIFFERENTIATION INCLUDES THE POLYCOMB GROUP (PCG) PROTEINS. THESE PROTEINS ARE TYPICALLY FOUND IN TWO DISTINCT TYPES OF POLYCOMB REPRESSIVE COMPLEXES (PRCS): PRC1 AND PRC2. THE PI'S LAB RECENTLY IDENTIFIED VARIANT PRC1 (VPRC1) COMPLEXES IN DROSOPHILA THAT HAVE STRONG MODULAR CONSERVATION WITH MAMMALIAN COMPLEXES, SUGGESTING AN ANCIENT FUNCTIONAL DIVERSITY. THE GOAL OF THIS WORK IS TO UNDERSTAND THE ROLE OF VPRC1 COMPLEXES IN COORDINATING THE CELL-TYPE SPECIFIC TRANSCRIPTION CRITICAL FOR NORMAL DEVELOPMENT. IN THIS PROJECT, UNDERGRADUATE STUDENT SCIENTISTS WILL FUNCTIONALLY CHARACTERIZE ONE OF THE VPRC1 COMPLEXES USING A VARIETY OF METHODS, INCLUDING CROSSLINKING, TANDEM AFFINITY PURIFICATION, AND INTEGRATED ANALYSIS OF PROTEIN PARTNERS AND DNA BINDING SITES, IN PARALLEL WITH FUNCTIONAL GENETIC APPROACHES TO DISSECT THE CHANGES IN PROTEIN COMPLEXES DURING NORMAL DEVELOPMENT IN DROSOPHILA. SUCCESSFUL COMPLETION OF THIS PROPOSAL WILL PROVIDE MECHANISTIC DETAILS FOR FUNCTION OF A VARIANT PRC1 COMPLEX IN DEVELOPMENTAL GENE REGULATION. RESULTING INSIGHTS WILL PROVE USEFUL FOR FUTURE ANALYSES IN MAMMALIAN CELLS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA. | $447.6K | FY2023 | Jun 2023 – May 2026 |
| National Science Foundation | RUI: CHARACTERIZING DNA TARGET SEARCH USING SINGLE MOLECULE METHODS | $378.8K | FY2021 | Aug 2021 – Jul 2024 |
| National Science Foundation | RUI: EARLY ENDINGS - CHARACTERIZING THE ROLE OF HRP1 IN RNA POLYMERASE II TRANSCRIPTION ATTENUATION -LIFE DEPENDS ON INFORMATION STORED IN DNA, WHICH IS EXPRESSED INTO RNA AND PROTEINS THAT PERFORM CELLULAR FUNCTIONS. AN INITIAL STEP OF GENE EXPRESSION IS TRANSCRIPTION, WHERE A MOLECULAR MACHINE CALLED RNA POLYMERASE READS DNA TO SYNTHESIZE RNA. AS RNA POLYMERASE MOVES ALONG DNA, IT CAN BE INTERRUPTED BY REGULATORY STOP SIGNALS THAT TERMINATE TRANSCRIPTION PREMATURELY. DOWNREGULATION OF GENE EXPRESSION BY EARLY TRANSCRIPTION STOPPAGE OCCURS WIDELY IN CELLS RANGING FROM BACTERIA TO HUMAN, BUT THE UNDERLYING MECHANISM AND SELECTIVITY REMAINS UNCLEAR. THIS RESEARCH PROJECT WILL INVESTIGATE PREMATURE TRANSCRIPTION TERMINATION IN THE YEAST S. CEREVISIAE, A TRACTABLE MODEL FOR STUDYING MANY CONSERVED BIOLOGICAL PROCESSES. UNDERGRADUATE STUDENT RESEARCHERS WILL BE TRAINED TO USE CLASSICAL GENETICS AND MODERN BIOINFORMATIC TOOLS TO DISSECT TRANSCRIPTION STOP SIGNALS AND DISCOVER MUTANTS THAT ALTER RECOGNITION. NEW GENE TARGETS WILL BE IDENTIFIED, WITH A BROADER GOAL OF IDENTIFYING SHARED REGULATORY FEATURES. STUDENT TRAINEES WILL HAVE OPPORTUNITIES TO PRESENT THEIR WORK AT NATIONAL RESEARCH CONFERENCES AND COAUTHOR PUBLICATIONS. THIS RESEARCH WILL ALSO BE INCORPORATED INTO A CORE UNDERGRADUATE BIOLOGY LABORATORY COURSE, MOBILIZING 50 ADDITIONAL STUDENTS TO VALIDATE GENE TARGETS. COURSE RESOURCES WILL BE SHARED BROADLY SO ADDITIONAL EDUCATIONAL COMMUNITIES MAY CONTRIBUTE AND BENEFIT. PREMATURE TRANSCRIPTION TERMINATION (ATTENUATION) OF EUKARYOTIC RNA POLYMERASE II (POL II) IS MORE PREVALENT THAN ONCE APPRECIATED BUT REMAINS ILL-DEFINED. THE INVESTIGATORS HYPOTHESIZE THAT A HYBRID TRANSCRIPTION TERMINATION PATHWAY INVOLVING THE HRP1 RNA-BINDING PROTEIN AND SEN1 HELICASE CONTRIBUTES BROADLY TO YEAST POL II ATTENUATION. THIS RESEARCH PROJECT WILL GENERATE A COMPREHENSIVE GENETIC PROFILE OF TEN NEWLY IDENTIFIED ATTENUATORS AND IDENTIFY THE LARGER REPERTOIRE OF HRP1-DEPENDENT ATTENUATORS ACROSS THE YEAST GENOME. IN AIM 1, A GENETIC SELECTION WILL IDENTIFY CIS-ACTING MUTATIONS THAT DISRUPT ATTENUATOR FUNCTION IN PLASMID-BASED REPORTER GENES, FOLLOWED BY CONFIRMATION IN CRISPR-EDITED GENOMIC DNA. A GENETIC SCREEN WILL PROBE THE EFFECT OF TRANS-ACTING MUTATIONS THAT ALTER TERMINATION FACTOR RECRUITMENT, POL II CTD MODIFICATION, AND POL II PAUSING. A DIRECT MECHANISM WILL BE ASSAYED USING HRP1 MUTANTS DEFECTIVE FOR BINDING RNA OR AFFILIATED PROTEINS. IN AIM 2, AN AUXIN-INDUCIBLE DEGRON SYSTEM WILL DEPLETE HRP1, FOLLOWED BY PRECISION NUCLEAR RUN-ON SEQUENCING (PRO-SEQ) TO MONITOR GENOME-WIDE POL II READ-THROUGH DEFECTS. THIS WORK WILL INFORM ANALYSIS OF THE HRP1 ORTHOLOG HNRNPDL, A HUMAN PROTEIN THAT LIKEWISE BINDS AU-RICH RNA AND REGULATES TRANSCRIPTION. IN ADDITION, ENGINEERED ATTENUATORS MAY BE HARNESSED FOR DYNAMIC GENE CONTROL IN BIOTECHNOLOGY APPLICATIONS, INCLUDING YEAST EXPRESSION OF INDUSTRIAL ENZYMES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA. | $372K | FY2022 | Feb 2022 – Jan 2025 |
| Department of Health and Human Services | FUNCTION OF HEMATOPOIETICALLY-DERIVED MYELOID PRECURSORS TO THE CENTRAL NERVOUS S | $357.3K | FY2014 | Jul 2014 – Dec 2017 |
| National Science Foundation | RUI: DISCOVERING AND CHARACTERIZING THE BINDING DETERMINANTS FOR RNA POLYMERASE-ASSOCIATED PROTEINS IN E. COLI | $351.5K | FY2017 | Jul 2017 – Jun 2021 |
| National Science Foundation | RUI: DNA AND NANOPARTICLE ASSEMBLIES AS BIOMIMETIC TEMPLATES FOR CALCIUM PHOSPHATE MINERALIZATION | $350.3K | FY2019 | Sep 2019 – Aug 2022 |
| National Science Foundation | RUI: ELUCIDATING THE MECHANISMS OF SITE SPECIFIC DNA CLEAVAGE USING SINGLE MOLECULE METHODS | $340.5K | FY2017 | Aug 2017 – Jul 2020 |
| Department of Education | EARMARKS | $309K | FY2009 | Jul 2009 – Jul 2010 |
| National Science Foundation | RUI: THE RATE OF EVOLUTION IN STRUCTURED POPULATIONS | $285.2K | FY2017 | Aug 2017 – Jul 2020 |
| Department of Energy | EMMANUEL COLLEGE CENTER FOR SCIENCE PARTNERSHIP | $279K | FY2008 | Sep 2008 – Apr 2009 |
| National Science Foundation | IOS PROPOSAL: EFFECTS OF VISION LOSS ON ASTROCYTE MATURATION AND OLIGODENDROCYTE MYELINATION VIA BDNF-ASSOCIATED MECHANISMS IN THE VISUAL CORTEX | $266K | FY2015 | Jul 2015 – Jun 2018 |
| Department of Education | DIRECTED GRANTS | $243.7K | FY2008 | Jul 2008 – Dec 2009 |
| National Science Foundation | RUI: SELECTION AND ASSESSMENT OF BIOMIMETIC TEMPLATES FOR MINERALIZATION | $240.1K | FY2013 | Jul 2013 – Jun 2016 |
| National Science Foundation | RUI: DEVELOPING MODELS OF FACILITATED DIFFUSION FOR DNA BINDING PROTEINS | $232.9K | FY2012 | Sep 2012 – Aug 2015 |
| Department of Education | EARMARKS | $200K | FY2010 | Jun 2010 – Nov 2010 |
| National Science Foundation | LEAPS-MPS: UNVEILING THE ORIGIN OF CARBON DOT FLUORESCENCE USING DENSITY FUNCTIONAL TIGHT BINDING -IN THIS PROJECT, MANAGED BY THE DIVISION OF CHEMISTRY AT THE NSF, PROFESSOR DUCHIMAZA HEREDIA AND STUDENTS AT EMMANUEL COLLEGE WILL USE COMPUTER SIMULATIONS TO UNDERSTAND WHY CARBON DOTS FLUORESCE. CARBON DOTS ARE FORMED BY A POLYMERIZATION REACTION OF SMALL MOLECULES AT HIGH TEMPERATURES, AND THEY HAVE BEEN OBSERVED TO GLOW IN VARIOUS COLORS. THE MULTICOLOR FLUORESCENCE OF CARBON DOTS MAKES THEM USEFUL IN APPLICATIONS INCLUDING DRUG DELIVERY, BIOSENSING, AND IMAGING. COMPUTATIONAL METHODS WILL BE EMPLOYED TO INVESTIGATE THE REASON FOR FLUORESCENCE, OVERCOMING EXPERIMENTAL CHALLENGES IN DETERMINING THE STRUCTURE OF THE CARBON DOTS. THIS PROJECT WILL CREATE RESEARCH POSITIONS THAT SUPPORT TRAINING FOR UNDERGRADUATE STUDENTS OF DIVERSE BACKGROUNDS AND ESTABLISH PARTNERSHIPS WITH COMPUTATIONAL CHEMISTS AROUND THE BOSTON AREA TO INTRODUCE STUDENTS TO A GRADUATE-LEVEL RESEARCH ENVIRONMENT. THE CHEMISTRY EDUCATION PATHWAY WILL BE STRENGTHENED BY INVOLVING HIGH SCHOOL TEACHERS IN THIS INVESTIGATION AND USING ASPECTS OF THIS PROJECT TO TEACH HIGH SCHOOL STUDENTS HOW COMPUTERS ARE USED IN CHEMISTRY RESEARCH. PROFESSOR DUCHIMAZA HEREDIA AND HIS COMPUTATIONAL CHEMISTRY RESEARCH GROUP WILL INVESTIGATE THE ELECTRONIC NATURE OF MULTICOLOR FLUORESCENCE IN POLYMERIC OR AMORPHOUS CARBON DOTS. EXISTING HYPOTHESES INCLUDE SIZE-DEPENDENT EMISSIONS, SURFACE-STATE DERIVED EMISSION, AND FLUORESCENCE DUE TO MOLECULAR FLUOROPHORES. WHILE FLUORESCENCE ACROSS THE VISIBLE SPECTRUM IS POSSIBLE, EXPERIMENTAL ANALYSIS SUPPORTS ONLY BLUE FLUORESCENCE. THE PROJECT WILL USE ENHANCED SAMPLING METHODS TO PREDICT THE STRUCTURE OF AMORPHOUS CARBON DOTS. IT WILL ALSO LEVERAGE THE CHEMICAL ACCURACY OF DENSITY FUNCTIONAL THEORY (DFT) AND THE SPEED OF DENSITY FUNCTIONAL-BASED TIGHT-BINDING (DFTB). THIS PROJECT AIMS TO DETERMINE WHETHER FLUORESCENCE IS POSSIBLE SOLELY DUE TO THE CARBON DOT STRUCTURE, IDENTIFY HOW THE ENVIRONMENT OF A FLUOROPHORE INFLUENCES ITS EMISSION PROPERTIES, AND PERFORM EXTENSIVE BENCHMARKING TO COMPARE THE RESULTS OF DFT AND DFTB FOR ACCURATE AND FAST PREDICTION OF CARBON DOT AND FLUOROPHORE SYSTEMS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD. | $57.6K | FY2024 | Sep 2024 – Dec 2025 |
Department of Education
$4.9M
U.S. DEPARTMENT OF EDUCATIONCARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND - IHES
Department of Education
$3.9M
U.S. DEPARTMENT OF EDUCATION CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND - IHES
Department of Education
$512.1K
EMERGENCY MANAGEMENT FOR HIGHER EDUCATION
National Science Foundation
$447.6K
BRC-BIO: ANALYZING THE ROLE OF DROSOPHILA VARIANT POLYCOMB REPRESSIVE COMPLEXES IN DEVELOPMENTAL GENE TRANSCRIPTION -MULTICELLULAR ORGANISMS ARE COMPOSED OF INDIVIDUAL CELLS THAT FUNCTION DISTINCTLY, DUE TO THE REGULATION OF GENE EXPRESSION DURING DEVELOPMENT. DEVELOPMENTAL GENE REGULATION IS LARGELY MADE POSSIBLE BY MANY PROTEIN COMPLEXES THAT TURN GENES ON OR OFF AT APPROPRIATE DEVELOPMENTAL WINDOWS. AN IMPORTANT EXAMPLE IS THE POLYCOMB REPRESSIVE COMPLEX, WHICH TURNS OFF A SPECIFIC SET OF DEVELOPMENTAL GENES. HOW THIS COMPLEX SELECTS THE CORRECT GENES TO SILENCE DURING EARLY DEVELOPMENT IS STILL UNKNOWN. THIS PROJECT WILL UTILIZE THE FRUIT FLY AS MODEL ORGANISM TO STUDY THE ROLE OF THIS SILENCING COMPLEX IN ORCHESTRATING DEVELOPMENTAL GENE EXPRESSION. DISCOVERING THE MECHANISM BY WHICH POLYCOMB REPRESSIVE COMPLEXES SILENCE GENES IN THE FRUIT FLY WILL INFORM OUR UNDERSTANDING OF DEVELOPMENT IN MAMMALS. ANOTHER SIGNIFICANT GOAL OF THIS PROJECT IS TO INCREASE THE PARTICIPATION OF PERSONS TRADITIONALLY EXCLUDED BECAUSE OF THEIR ETHNICITY OR RACE (PEERS) IN UNDERGRADUATE RESEARCH EXPERIENCES AT EMMANUEL COLLEGE. STUDENT RESEARCHERS WILL USE GENETIC, MOLECULAR, AND BIOCHEMICAL TECHNIQUES TO ADDRESS THE AIMS OF THIS PROJECT. COLLABORATIONS WITH RESEARCHERS FROM HARVARD MEDICAL SCHOOL AND BRANDEIS UNIVERSITY WILL FACILITATE ENGAGEMENT OF PEER UNDERGRADUATE STUDENTS WITH THE BROADER SCIENTIFIC COMMUNITY. THE GOAL IS TO INSPIRE LARGER NUMBERS OF PEER STUDENTS TO PURSUE CAREERS IN STEM. MULTICELLULAR DEVELOPMENT IS GOVERNED BY THE DEPLOYMENT OF CELL-TYPE SPECIFIC TRANSCRIPTIONAL PROGRAMMING, IN WHICH A SINGLE GENOME IS UTILIZED DISTINCTLY OVER TIME AND SPACE AS CELLS MULTIPLY AND SPECIALIZE. THIS PHENOMENON IS ACHIEVED BY THE PRECISE COORDINATION OF GENE EXPRESSION THAT INITIATES THE DIFFERENTIATION OF THE DIFFERENT CELL TYPES OF AN ORGANISM. CHROMATIN REGULATORY FACTORS HAVE BEEN FOUND TO BE ESSENTIAL FOR REGULATION OF DEVELOPMENTAL TRANSCRIPTIONAL PROGRAMMING HOWEVER THE MECHANISM BEHIND HOW THESE FACTORS COORDINATE GENE EXPRESSION DURING EMBRYONIC DEVELOPMENT REMAINS UNCLEAR. ONE HIGHLY CONSERVED CHROMATIN REGULATORY SYSTEM THAT PLAYS A CENTRAL ROLE IN DEVELOPMENTAL PATTERNING AND CELL DIFFERENTIATION INCLUDES THE POLYCOMB GROUP (PCG) PROTEINS. THESE PROTEINS ARE TYPICALLY FOUND IN TWO DISTINCT TYPES OF POLYCOMB REPRESSIVE COMPLEXES (PRCS): PRC1 AND PRC2. THE PI'S LAB RECENTLY IDENTIFIED VARIANT PRC1 (VPRC1) COMPLEXES IN DROSOPHILA THAT HAVE STRONG MODULAR CONSERVATION WITH MAMMALIAN COMPLEXES, SUGGESTING AN ANCIENT FUNCTIONAL DIVERSITY. THE GOAL OF THIS WORK IS TO UNDERSTAND THE ROLE OF VPRC1 COMPLEXES IN COORDINATING THE CELL-TYPE SPECIFIC TRANSCRIPTION CRITICAL FOR NORMAL DEVELOPMENT. IN THIS PROJECT, UNDERGRADUATE STUDENT SCIENTISTS WILL FUNCTIONALLY CHARACTERIZE ONE OF THE VPRC1 COMPLEXES USING A VARIETY OF METHODS, INCLUDING CROSSLINKING, TANDEM AFFINITY PURIFICATION, AND INTEGRATED ANALYSIS OF PROTEIN PARTNERS AND DNA BINDING SITES, IN PARALLEL WITH FUNCTIONAL GENETIC APPROACHES TO DISSECT THE CHANGES IN PROTEIN COMPLEXES DURING NORMAL DEVELOPMENT IN DROSOPHILA. SUCCESSFUL COMPLETION OF THIS PROPOSAL WILL PROVIDE MECHANISTIC DETAILS FOR FUNCTION OF A VARIANT PRC1 COMPLEX IN DEVELOPMENTAL GENE REGULATION. RESULTING INSIGHTS WILL PROVE USEFUL FOR FUTURE ANALYSES IN MAMMALIAN CELLS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.
National Science Foundation
$378.8K
RUI: CHARACTERIZING DNA TARGET SEARCH USING SINGLE MOLECULE METHODS
National Science Foundation
$372K
RUI: EARLY ENDINGS - CHARACTERIZING THE ROLE OF HRP1 IN RNA POLYMERASE II TRANSCRIPTION ATTENUATION -LIFE DEPENDS ON INFORMATION STORED IN DNA, WHICH IS EXPRESSED INTO RNA AND PROTEINS THAT PERFORM CELLULAR FUNCTIONS. AN INITIAL STEP OF GENE EXPRESSION IS TRANSCRIPTION, WHERE A MOLECULAR MACHINE CALLED RNA POLYMERASE READS DNA TO SYNTHESIZE RNA. AS RNA POLYMERASE MOVES ALONG DNA, IT CAN BE INTERRUPTED BY REGULATORY STOP SIGNALS THAT TERMINATE TRANSCRIPTION PREMATURELY. DOWNREGULATION OF GENE EXPRESSION BY EARLY TRANSCRIPTION STOPPAGE OCCURS WIDELY IN CELLS RANGING FROM BACTERIA TO HUMAN, BUT THE UNDERLYING MECHANISM AND SELECTIVITY REMAINS UNCLEAR. THIS RESEARCH PROJECT WILL INVESTIGATE PREMATURE TRANSCRIPTION TERMINATION IN THE YEAST S. CEREVISIAE, A TRACTABLE MODEL FOR STUDYING MANY CONSERVED BIOLOGICAL PROCESSES. UNDERGRADUATE STUDENT RESEARCHERS WILL BE TRAINED TO USE CLASSICAL GENETICS AND MODERN BIOINFORMATIC TOOLS TO DISSECT TRANSCRIPTION STOP SIGNALS AND DISCOVER MUTANTS THAT ALTER RECOGNITION. NEW GENE TARGETS WILL BE IDENTIFIED, WITH A BROADER GOAL OF IDENTIFYING SHARED REGULATORY FEATURES. STUDENT TRAINEES WILL HAVE OPPORTUNITIES TO PRESENT THEIR WORK AT NATIONAL RESEARCH CONFERENCES AND COAUTHOR PUBLICATIONS. THIS RESEARCH WILL ALSO BE INCORPORATED INTO A CORE UNDERGRADUATE BIOLOGY LABORATORY COURSE, MOBILIZING 50 ADDITIONAL STUDENTS TO VALIDATE GENE TARGETS. COURSE RESOURCES WILL BE SHARED BROADLY SO ADDITIONAL EDUCATIONAL COMMUNITIES MAY CONTRIBUTE AND BENEFIT. PREMATURE TRANSCRIPTION TERMINATION (ATTENUATION) OF EUKARYOTIC RNA POLYMERASE II (POL II) IS MORE PREVALENT THAN ONCE APPRECIATED BUT REMAINS ILL-DEFINED. THE INVESTIGATORS HYPOTHESIZE THAT A HYBRID TRANSCRIPTION TERMINATION PATHWAY INVOLVING THE HRP1 RNA-BINDING PROTEIN AND SEN1 HELICASE CONTRIBUTES BROADLY TO YEAST POL II ATTENUATION. THIS RESEARCH PROJECT WILL GENERATE A COMPREHENSIVE GENETIC PROFILE OF TEN NEWLY IDENTIFIED ATTENUATORS AND IDENTIFY THE LARGER REPERTOIRE OF HRP1-DEPENDENT ATTENUATORS ACROSS THE YEAST GENOME. IN AIM 1, A GENETIC SELECTION WILL IDENTIFY CIS-ACTING MUTATIONS THAT DISRUPT ATTENUATOR FUNCTION IN PLASMID-BASED REPORTER GENES, FOLLOWED BY CONFIRMATION IN CRISPR-EDITED GENOMIC DNA. A GENETIC SCREEN WILL PROBE THE EFFECT OF TRANS-ACTING MUTATIONS THAT ALTER TERMINATION FACTOR RECRUITMENT, POL II CTD MODIFICATION, AND POL II PAUSING. A DIRECT MECHANISM WILL BE ASSAYED USING HRP1 MUTANTS DEFECTIVE FOR BINDING RNA OR AFFILIATED PROTEINS. IN AIM 2, AN AUXIN-INDUCIBLE DEGRON SYSTEM WILL DEPLETE HRP1, FOLLOWED BY PRECISION NUCLEAR RUN-ON SEQUENCING (PRO-SEQ) TO MONITOR GENOME-WIDE POL II READ-THROUGH DEFECTS. THIS WORK WILL INFORM ANALYSIS OF THE HRP1 ORTHOLOG HNRNPDL, A HUMAN PROTEIN THAT LIKEWISE BINDS AU-RICH RNA AND REGULATES TRANSCRIPTION. IN ADDITION, ENGINEERED ATTENUATORS MAY BE HARNESSED FOR DYNAMIC GENE CONTROL IN BIOTECHNOLOGY APPLICATIONS, INCLUDING YEAST EXPRESSION OF INDUSTRIAL ENZYMES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.
Department of Health and Human Services
$357.3K
FUNCTION OF HEMATOPOIETICALLY-DERIVED MYELOID PRECURSORS TO THE CENTRAL NERVOUS S
National Science Foundation
$351.5K
RUI: DISCOVERING AND CHARACTERIZING THE BINDING DETERMINANTS FOR RNA POLYMERASE-ASSOCIATED PROTEINS IN E. COLI
National Science Foundation
$350.3K
RUI: DNA AND NANOPARTICLE ASSEMBLIES AS BIOMIMETIC TEMPLATES FOR CALCIUM PHOSPHATE MINERALIZATION
National Science Foundation
$340.5K
RUI: ELUCIDATING THE MECHANISMS OF SITE SPECIFIC DNA CLEAVAGE USING SINGLE MOLECULE METHODS
Department of Education
$309K
EARMARKS
National Science Foundation
$285.2K
RUI: THE RATE OF EVOLUTION IN STRUCTURED POPULATIONS
Department of Energy
$279K
EMMANUEL COLLEGE CENTER FOR SCIENCE PARTNERSHIP
National Science Foundation
$266K
IOS PROPOSAL: EFFECTS OF VISION LOSS ON ASTROCYTE MATURATION AND OLIGODENDROCYTE MYELINATION VIA BDNF-ASSOCIATED MECHANISMS IN THE VISUAL CORTEX
Department of Education
$243.7K
DIRECTED GRANTS
National Science Foundation
$240.1K
RUI: SELECTION AND ASSESSMENT OF BIOMIMETIC TEMPLATES FOR MINERALIZATION
National Science Foundation
$232.9K
RUI: DEVELOPING MODELS OF FACILITATED DIFFUSION FOR DNA BINDING PROTEINS
Department of Education
$200K
EARMARKS
National Science Foundation
$57.6K
LEAPS-MPS: UNVEILING THE ORIGIN OF CARBON DOT FLUORESCENCE USING DENSITY FUNCTIONAL TIGHT BINDING -IN THIS PROJECT, MANAGED BY THE DIVISION OF CHEMISTRY AT THE NSF, PROFESSOR DUCHIMAZA HEREDIA AND STUDENTS AT EMMANUEL COLLEGE WILL USE COMPUTER SIMULATIONS TO UNDERSTAND WHY CARBON DOTS FLUORESCE. CARBON DOTS ARE FORMED BY A POLYMERIZATION REACTION OF SMALL MOLECULES AT HIGH TEMPERATURES, AND THEY HAVE BEEN OBSERVED TO GLOW IN VARIOUS COLORS. THE MULTICOLOR FLUORESCENCE OF CARBON DOTS MAKES THEM USEFUL IN APPLICATIONS INCLUDING DRUG DELIVERY, BIOSENSING, AND IMAGING. COMPUTATIONAL METHODS WILL BE EMPLOYED TO INVESTIGATE THE REASON FOR FLUORESCENCE, OVERCOMING EXPERIMENTAL CHALLENGES IN DETERMINING THE STRUCTURE OF THE CARBON DOTS. THIS PROJECT WILL CREATE RESEARCH POSITIONS THAT SUPPORT TRAINING FOR UNDERGRADUATE STUDENTS OF DIVERSE BACKGROUNDS AND ESTABLISH PARTNERSHIPS WITH COMPUTATIONAL CHEMISTS AROUND THE BOSTON AREA TO INTRODUCE STUDENTS TO A GRADUATE-LEVEL RESEARCH ENVIRONMENT. THE CHEMISTRY EDUCATION PATHWAY WILL BE STRENGTHENED BY INVOLVING HIGH SCHOOL TEACHERS IN THIS INVESTIGATION AND USING ASPECTS OF THIS PROJECT TO TEACH HIGH SCHOOL STUDENTS HOW COMPUTERS ARE USED IN CHEMISTRY RESEARCH. PROFESSOR DUCHIMAZA HEREDIA AND HIS COMPUTATIONAL CHEMISTRY RESEARCH GROUP WILL INVESTIGATE THE ELECTRONIC NATURE OF MULTICOLOR FLUORESCENCE IN POLYMERIC OR AMORPHOUS CARBON DOTS. EXISTING HYPOTHESES INCLUDE SIZE-DEPENDENT EMISSIONS, SURFACE-STATE DERIVED EMISSION, AND FLUORESCENCE DUE TO MOLECULAR FLUOROPHORES. WHILE FLUORESCENCE ACROSS THE VISIBLE SPECTRUM IS POSSIBLE, EXPERIMENTAL ANALYSIS SUPPORTS ONLY BLUE FLUORESCENCE. THE PROJECT WILL USE ENHANCED SAMPLING METHODS TO PREDICT THE STRUCTURE OF AMORPHOUS CARBON DOTS. IT WILL ALSO LEVERAGE THE CHEMICAL ACCURACY OF DENSITY FUNCTIONAL THEORY (DFT) AND THE SPEED OF DENSITY FUNCTIONAL-BASED TIGHT-BINDING (DFTB). THIS PROJECT AIMS TO DETERMINE WHETHER FLUORESCENCE IS POSSIBLE SOLELY DUE TO THE CARBON DOT STRUCTURE, IDENTIFY HOW THE ENVIRONMENT OF A FLUOROPHORE INFLUENCES ITS EMISSION PROPERTIES, AND PERFORM EXTENSIVE BENCHMARKING TO COMPARE THE RESULTS OF DFT AND DFTB FOR ACCURATE AND FAST PREDICTION OF CARBON DOT AND FLUOROPHORE SYSTEMS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.
Source: Federal Audit Clearinghouse (fac.gov)
No federal single audit records found for this organization.
Single audits are required for entities expending $750,000+ in federal awards annually.
Tax Year 2024 · Source: IRS e-Filed Form 990Schedule J available
Individuals serving as officers, directors, or trustees of the organization.
| Name | Title | Hrs/Wk | Compensation | Related Orgs | Other |
|---|
Source: IRS Publication 78, Auto-Revocation List & e-Postcard Data
Tax-deductible contributions: Not confirmed
No additional tax-exempt status records found in ReconForce's database.
Sources: IRS e-Filed Form 990 (XML) & ProPublica Nonprofit Explorer
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| Year | Revenue | Contributions | Expenses | Assets | Net Assets |
|---|---|---|---|---|---|
| 2023IRS e-File | $35.4M | $8.7M | $26.5M | $541.3M | $496.1M |
| 2022IRS e-File | $31.9M | $6.5M | $24.9M | $482.8M | $437.3M |
| 2021 | $32.1M | $10.6M | $22.1M | $520.8M | $459.2M |
| 2020 | $30.8M |
Sources: ProPublica Nonprofit Explorer & IRS e-File Index
| Tax Year | Form Type | Source | Documents |
|---|---|---|---|
| 2024 | 990 | IRS e-File | PDF not yet published by IRSView Filing → |
| 2023 | 990 | DataIRS e-File | PDF not yet published by IRSView Filing → |
| 2022 | 990 | DataIRS e-File |
Financial data: IRS e-Filed Form 990 (Tax Year 2023)
Leadership & compensation: IRS e-Filed Form 990, Part VII (Tax Year 2024)
Federal grants: USAspending.gov (live)
Organization info: IRS Business Master File
| Total |
|---|
| Mr Doug Chalmers | Master | 5 | $186.9K | $0 | $0 | $186.9K |
| Dr C Russell | Senior Tutor | 5 | $142.3K | $0 | $0 | $142.3K |
| Prof R Henderson | Resigned '23 | — | $22.2K | $0 | $0 | $22.2K |
| Prof S Rankin | Vice Master | 5 | $4,228 | $0 | $0 | $4,228 |
Mr Doug Chalmers
Master
$186.9K
Hrs/Wk
5
Compensation
$186.9K
Related Orgs
$0
Other
$0
Dr C Russell
Senior Tutor
$142.3K
Hrs/Wk
5
Compensation
$142.3K
Related Orgs
$0
Other
$0
Prof R Henderson
Resigned '23
$22.2K
Hrs/Wk
—
Compensation
$22.2K
Related Orgs
$0
Other
$0
Prof S Rankin
Vice Master
$4,228
Hrs/Wk
5
Compensation
$4,228
Related Orgs
$0
Other
$0
Members of the governing board. Board members often serve without compensation.
| Name | Title | Hrs/Wk | Compensation | Related Orgs | Other | Total |
|---|---|---|---|---|---|---|
| Dr A S Bendall | Resigned '23 | — | $0 | $0 | $0 | $0 |
| Dr D Curtis | Council Member | 5 | $25.6K | $0 | $0 | $25.6K |
| Dr K E Spence | Resigned '23 | — | $0 | $0 | $0 | $0 |
| Dr R Broadbent | Council Member | 5 | $0 | $0 | $0 | $0 |
| Dr R Wilson | Council Member | 5 | $21.6K | $0 | $0 | $21.6K |
| Ms Catherine Webb |
Dr A S Bendall
Resigned '23
$0
Hrs/Wk
—
Compensation
$0
Related Orgs
$0
Other
$0
Dr D Curtis
Council Member
$25.6K
Hrs/Wk
5
Compensation
$25.6K
Related Orgs
$0
Other
$0
Dr K E Spence
Resigned '23
$0
Hrs/Wk
—
Compensation
$0
Related Orgs
$0
Other
$0
| $9.6M |
| $18.2M |
| $415M |
| $360.6M |
| 2019 | $29.1M | $5.1M | $20.5M | $423.6M | $360.6M |
| 2018 | $27.8M | $6.7M | $19.8M | $420.9M | $368.2M |
| 2017 | $24.8M | $7.3M | $17M | $337.3M | $314M |
| 2016 | $24.9M | $7.3M | $17.2M | $310.9M | $289.8M |
| 2015 | $28.7M | $5.8M | $20.1M | $347M | $319.8M |
| 2014 | $25.5M | $4.2M | $21.8M | $340.5M | $312.7M |
| 2013 | $20M | $1.4M | $17.5M | $297.2M | $270.9M |
| 2012 | $19.8M | $1.6M | $16.6M | $231.2M | $209.9M |
| 2011 | $18.7M | $2.3M | $22.1M | $272.5M | $251.8M |
| 2021 | 990 | Data | PDF not yet published by IRS |
| 2020 | 990 | Data | PDF not yet published by IRS |
| 2019 | 990 | Data |
| 2018 | 990 | Data |
| 2017 | 990 | Data |
| 2016 | 990 | Data |
| 2015 | 990 | Data |
| 2014 | 990 | Data |
| 2013 | 990 | Data |
| 2012 | 990 | Data |
| 2011 | 990 | Data |
| 2010 | 990 | — |
| 2009 | 990 | — |
| Bursar |
| 5 |
| $167.6K |
| $0 |
| $0 |
| $167.6K |
| Prof A Jeffrey | Council Member | 5 | $37.9K | $0 | $0 | $37.9K |
| Prof L Bentley | Council Member | 5 | $0 | $0 | $0 | $0 |
| Prof N Peake | Council Member | 5 | $153 | $0 | $0 | $153 |
| Prof P Howell | Council Member | 5 | $42.9K | $0 | $0 | $42.9K |
| Prof S P Oakley | Council Member | 5 | $6,662 | $0 | $0 | $6,662 |
| Revd J L Caddick | Resigned '23 | — | $0 | $0 | $0 | $0 |
Dr R Broadbent
Council Member
$0
Hrs/Wk
5
Compensation
$0
Related Orgs
$0
Other
$0
Dr R Wilson
Council Member
$21.6K
Hrs/Wk
5
Compensation
$21.6K
Related Orgs
$0
Other
$0
Ms Catherine Webb
Bursar
$167.6K
Hrs/Wk
5
Compensation
$167.6K
Related Orgs
$0
Other
$0
Prof A Jeffrey
Council Member
$37.9K
Hrs/Wk
5
Compensation
$37.9K
Related Orgs
$0
Other
$0
Prof L Bentley
Council Member
$0
Hrs/Wk
5
Compensation
$0
Related Orgs
$0
Other
$0
Prof N Peake
Council Member
$153
Hrs/Wk
5
Compensation
$153
Related Orgs
$0
Other
$0
Prof P Howell
Council Member
$42.9K
Hrs/Wk
5
Compensation
$42.9K
Related Orgs
$0
Other
$0
Prof S P Oakley
Council Member
$6,662
Hrs/Wk
5
Compensation
$6,662
Related Orgs
$0
Other
$0
Revd J L Caddick
Resigned '23
$0
Hrs/Wk
—
Compensation
$0
Related Orgs
$0
Other
$0