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AMP-AD DATA COORDINATION CENTER

INTEGRATING CANCER DATASETS FOR PREDICTIVE MODEL DEVELOPMENT AND TRAINING

EXCEPTIONAL LONGEVITY DATA MANAGEMENT AND COORDINATING CENTER - ADVANCED AGE IS THE PRIMARY RISK FACTOR FOR DEVELOPING DEMENTIA DUE TO ALZHEIMER’S DISEASE (AD) AND ALZHEIMER’S DISEASE RELATED DISORDERS (ADRD). INVESTIGATING THE FACTORS THAT CONTRIBUTE TO HEALTHY AGING AND EXCEPTIONAL LONG LIFE REPRESENTS AN OPPORTUNITY TO REDUCE THE BURDEN OF DISEASES OF AGING INCLUDING ALZHEIMER’S AND RELATED DEMENTIAS. TO THIS END, THE NATIONAL INSTITUTE ON AGING (NIA) HAS ESTABLISHED FOUR LONGEVITY TRANSLATIONAL PROJECTS WORKING TO IDENTIFY GENETIC AND OTHER MOLECULAR SIGNATURES OF LONG LIFE AND RESILIENCE TO AGE-RELATED DISEASES IN HUMANS AND NON-HUMAN SPECIES. EMPLOYING TEAM SCIENCE APPROACHES TO ASSEMBLE THE COMPLEMENTARY APPROACHES AND EXPERTISE OF THE DOZENS OF RESEARCHERS ACROSS THIS NETWORK PRESENTS A POWERFUL OPPORTUNITY TO EXTEND AND INTEGRATE THIS WORK BY AGGREGATING RESOURCES AND KNOWLEDGE ACROSS DOMAINS, INCLUDING ALZHEIMER’S AND RELATED DEMENTIAS. THE OVERARCHING GOAL OF THE PROPOSED EXCEPTIONAL LONGEVITY DATA MANAGEMENT AND COORDINATION CORE (EL DMCC) IS TO AID THE EL RESEARCH COMMUNITY IN THESE EFFORTS BY FACILITATING RESEARCH ON PROTECTIVE FACTORS THAT CONTRIBUTE TO EXCEPTIONAL HEALTH AND RESILIENCE TO AGE-RELATED DISEASES LIKE AD AND ADRD. THE DMCC WILL ADDRESS THIS GOAL BY (1) ESTABLISHING A DYNAMIC CATALOG OF EL DATA AND RESOURCES, (2) INITIATING CROSS-TEAM ANALYTICAL PROJECTS AND DATA CHALLENGES TO LEVERAGE EXPERTISE AND DATA FROM ACROSS THE EL PROJECTS AND IN CONJUNCTION WITH AD RESILIENCE PROJECTS, (3) DEVELOPING AN EL KNOWLEDGE PORTAL TO ACT AS A CENTRAL HUB FOR EL RESEARCH RESOURCES, AND (4) PILOTING A LIMITED DATA COMMONS TO ENABLE FACILE COMPUTATION ON EL AND AD DATA WITHIN THE CLOUD ENVIRONMENT FOR EL INVESTIGATORS.

MULTI-CONSORTIA COORDINATING CENTER (MC2 CENTER) FOR CANCER BIOLOGY: BUILDING INTERDISCIPLINARY SCIENTIFIC COMMUNITIES, COORDINATING IMPACTFUL RESOURCE SHARING, AND ADVANCING CANCER RESEARCH - PROJECT SUMMARY SYSTEMS BIOLOGY HAS BEEN AN INSTRUMENTAL APPROACH TO OVERCOMING CHALLENGES IN BIOMEDICAL RESEARCH, WHERE SOLUTIONS ARISE FROM INTERDISCIPLINARY EFFORTS, SHARED RESOURCES (DATA, TOOLS, MODELS, EXPERTISE) AND INTEGRATIVE ANALYSES. THE NCI DIVISION OF CANCER BIOLOGY (DCB) HAS CREATED MULTIPLE CONSORTIA COMPRISING INTERDISCIPLINARY COMMUNITIES OF SCIENTISTS WHO AIM TO INTEGRATE APPROACHES, DATA, AND TOOLS TO ADDRESS IMPORTANT QUESTIONS IN BASIC AND TRANSLATIONAL CANCER RESEARCH. THE MULTI-CONSORTIA COORDINATING (MC2) CENTER FOR CANCER BIOLOGY WILL WORK ACROSS PROGRAMS TO MOTIVATE ENGAGEMENT AND COLLABORATION, SUPPORT RESOURCE SHARING, AND DISSEMINATE KNOWLEDGE AND RESOURCES TO THE BROADER SCIENTIFIC COMMUNITY. THE MC2 CENTER WILL OPERATE THROUGH THREE HUBS. THE COLLABORATION HUB WILL USE EVIDENCE-BASED STRATEGIES TO CATALYZE INTERACTIONS AND NEW COLLABORATIONS. AN EVALUATION FRAMEWORK WILL BE DEVELOPED WITH QUANTITATIVE AND QUALITATIVE METRICS TO ENSURE THE CENTER CONTINUOUSLY IMPROVES ITS IMPACT. COMMUNITY ENGAGEMENT ACTIVITIES WILL INCLUDE WORKING GROUPS, SPECIAL INTEREST GROUPS, DREAM CHALLENGES, AND IDEATION JAMS, ALL OF WHICH WILL HAVE MECHANISMS FOR ENSURING INCLUSION AND PROMOTING DIVERSITY. TO FACILITATE SHARING OF RESOURCES FROM DCB PROGRAMS, THE RESOURCE COORDINATION HUB WILL ENSURE ALL RESOURCES ARE FINDABLE, ACCESSIBLE, INTEROPERABLE AND REUSABLE (FAIR); IT WILL IDENTIFY OR DEVELOP OPEN AND FAIR STANDARDS AND BEST PRACTICES; PROVIDE TRAINING ON HOW TO IMPLEMENT THESE STANDARDS AND PRACTICES IN THE CANCER RESEARCH COMMUNITY; AND PROVIDE TOOLING AND INTERFACES TO FACILITATE RESOURCE SHARING, CURATION, AND DEPOSITION IN PUBLIC REPOSITORIES. FINALLY, THE OUTREACH HUB WILL ENHANCE DISSEMINATION OF KNOWLEDGE AND RESOURCES THROUGH TRAINING MATERIALS TO MAXIMIZE UTILIZATION OF TOOLS AND SHORT COURSES AND WORKSHOPS THAT BRING CONCEPTS AND RESOURCES FROM ACROSS THE DCB PROGRAMS TOGETHER, ENABLING THE BROADER COMMUNITY TO EXPERIENCE THE POWER OF AN INTEGRATIVE INTERDISCIPLINARY APPROACH TO CANCER. THE CANCER COMPLEXITY KNOWLEDGE PORTAL WILL CONTINUE TO PROVIDE OPEN ACCESS TO ALL DATA, TOOLS, AND OTHER RESOURCES GENERATED THROUGH THE DCB AND MC2, HIGHLIGHTING DISCOVERIES AND ENABLING EXPLORATION INTO THE MANY VALUABLE RESOURCES GENERATED BY DCB PROGRAMS.

COORDINATION CENTER FOR OPEN COLLABORATION IN SYSTEMS BIOLOGY

OPEN SYSTEMS FOR AMP-AD TARGET ENHANCEMENT

ADVANCING METHOD BENCHMARKING AND DATA SHARING THROUGH CROWD-SOURCED COMPETITIONS IN CANCER RESEARCH

RESILIENCE TO INFECTION: AN OPEN INNOVATION CHALLENGE TO THE COMMUNITY

BUILDING A NEXT GENERATION MODEL FOR BIOMEDICAL RESEARCH: VALIDATION OF HEALTH SENSORS USING ONLINE COMMUNITY REGISTRIES AND COLLABORATIVE DATA INTER