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Source: IRS Form 990 via ProPublica Nonprofit Explorer
Total Revenue
▼$40.5K
Total Contributions
N/A
Total Expenses
▼$44.3K
Total Assets
$9,247
Total Liabilities
▼$0
Net Assets
N/A
Officer Compensation
→N/A
Other Salaries
N/A
Investment Income
▼N/A
Fundraising
▼N/A
Source: USAspending.gov · Searched by organization name
VA/DoD Awards
$50K
VA/DoD Award Count
1
Funding from the Department of Veterans Affairs and/or Department of Defense.
Total Federal Funding
$15.8M
Awards Found
24
| Awarding Agency | Description | Amount | Fiscal Year | Period |
|---|---|---|---|---|
| Department of Health and Human Services | ADVANCED THERAPEUTIC FOR PARKINSON'S DISEASE | $6.2M | FY2017 | Sep 2017 – Aug 2022 |
| Department of Health and Human Services | NOVEL DFG OUT INHIBITORS OF ABL-KINASES TO TREAT PML | $3.5M | FY2012 | Sep 2012 – Feb 2020 |
| Department of Health and Human Services | ADVANCED PRODRUG TREATMENT FOR CML | $2M | FY2017 | Sep 2017 – Aug 2021 |
| Department of Agriculture | WASTE DISPOSAL GRANTS - REGULAR | $1.7M | FY2018 | Jan 2018 – Jan 2018 |
| Department of Agriculture | WASTE DISPOSAL GRANTS - REGULAR | $1M | FY2008 | Mar 2008 – Mar 2008 |
| Department of Health and Human Services | KINASE ACTIVATION IN MULTIPLE SYSTEM ATROPHY - MULTIPLE SYSTEM ATROPHY (MSA) IS AN UNRELENTING NEURODEGENERATIVE DISORDER WITH AN UNCERTAIN ETIOLOGY AND PATHOPHYSIOLOGY. MSA IS A UNIQUE PROTEINOPATHY IN WHICH ALPHA-SYNUCLEIN ACCUMULATES PREFERENTIALLY IN OLIGODENDROGLIA RATHER THAN NEURONS. ACCUMULATED ALPHA-SYNUCLEIN, KNOWN AS A GLIAL CYTOPLASMIC INCLUSION (GCI), IS THOUGHT TO ELICIT CHANGES IN OLIGODENDROCYTE FUNCTION, SUCH AS REDUCED NEUROTROPHIC SUPPORT AND DEMYELINATION, LEADING TO NEURODEGENERATION. WE HAVE DEVELOPED NOVEL RAT AND NONHUMAN PRIMATE (NHP) MODELS OF MSA BY EXPRESSING ALPHA-SYNUCLEIN IN OLIGODENDROGLIA USING A NOVEL GLIALOLIGODENDROCYTE-TROPHIC ADENO-ASSOCIATED VIRUS (AAV) VECTOR, OLIG001. HISTOLOGICAL ANALYSIS SHOWED WIDESPREAD EXPRESSION OF OLIGO01- LINKED ALPHA-SYNUCLEIN THROUGHOUT THE STRIATUM AND CORPUS CALLOSUM IN RAT BRAIN WITH >90% LOCALIZED TO OLIGODENDROGLIA AND LITTLE TO NO EXPRESSION IN NEURONS OR ASTROCYTES. THE MODEL ALSO DISPLAYS DEMYELINATION IN THE WHITE MATTER TRACTS OF THE CORPUS CALLOSUM AND STRIATUM, SIMILAR TO WHAT IS OBSERVED IN PATIENT BRAIN. ANALYSIS OF GCIS FROM THE MODEL ANIMALS REVEALED THAT THEY CONTAIN DISEASE-SPECIFIC PHOSPHORYLATIONS AT TYR39 AND SER129 THAT ARE IDENTICAL TO THE MODIFICATIONS OF ALPHA-SYNUCLEIN SEEN IN NEURONS OF PARKINSON'S DISEASE (PD) PATIENTS. THE UNEXPECTED OBSERVATION OF THESE MODIFICATIONS IN MSA MODEL BRAIN WERE ALSO FOUND IN MSA PATIENT BRAIN (SEE INNOVATION) FURTHER VALIDATED THE SUITABILITY OF THIS RAT MODEL FOR THE STUDY OF DISEASE MECHANISM IN MSA. WHILE BOTH MSA AND PD ARE SYNUCLEINOPATHIES, IT HAS LONG BEEN THOUGHT THAT THE ORIGIN OF PATHOLOGY FOR THESE TWO DISEASES WERE DISTINCT. THE OBSERVATION OF DISEASE-SPECIFIC CHEMICAL MODIFICATIONS IN MSA THAT ARE IDENTICAL TO WHAT IS OBSERVED IN PD SUGGESTS A CLOSER MECHANISTIC LINKAGE BETWEEN THESE DISPARATE DISEASES. IN PARTICULAR, SINCE ACTIVATION OF THE ABELSON TYROSINE KINASE C-ABL IS A KEY DISEASE-INITIATING EVENT IN PD THAT RESULTS IN PHOSPHORYLATION AT TYR39, IT IS POSSIBLE THAT C-ABL PLAYS A SIMILAR ROLE IN MSA AND THAT CHEMICAL INHIBITION OF C- ABL COULD BE DISEASE-MODIFYING IN MSA. THIS SUGGESTS THAT TREATMENT FOR MSA MAY BE BENEFITED BY AN ORALLY BIOAVAILABLE, BRAIN-PENETRANT C-ABL KINASE INHIBITOR, JUST AS WE'VE SHOWN FOR PARKINSON'S DISEASE. USING THIS NEWLY DEFINED MODEL OF MSA, WE PROPOSE TO DETERMINE WHETHER MSA HAS THE SAME CRITICAL DEPENDENCY ON C-ABL ACTIVATION THAT HAS BEEN FOUND IN PD, PAVING THE WAY FOR DISEASE MODIFYING THERAPY. | $385.9K | FY2021 | Sep 2021 – Aug 2023 |
| Department of Health and Human Services | PML ANTIVIRAL FOR AIDS | $303K | FY2009 | Sep 2009 – Aug 2011 |
| Department of Health and Human Services | DFG-OUT INHIBITORS OF ABL-KINASES TO TREAT PML | $300K | FY2013 | Aug 2013 – Jun 2015 |
| Appalachian Regional Commission | SEWER SYSTEM (UPGRADE) | $300K | FY2008 | Sep 2008 – Dec 2008 |
| Department of Health and Human Services | PRODRUG TREATMENT FOR CML | $284.8K | FY2017 | Sep 2017 – Aug 2018 |
| Department of Agriculture | REAP ENERGY EFFICIENCY IMPROVEMENT (EEI) GRANT UNRESTRICTED AMOUNT | $256.1K | FY2025 | Jan 2025 – Jan 2027 |
| Department of Agriculture | REAP ENERGY EFFICIENCY IMPROVEMENT (EEI) GRANT UNRESTRICTED AMOUNT | $80K | FY2023 | Jul 2023 – Jul 2025 |
| Department of Transportation | 1 RETROFIT AND 1 NEW LIFT | $71.9K | FY2012 | Jul 2012 – — |
| Department of Agriculture | REAP ENERGY EFFICIENCY IMPROVEMENT (EEI) GRANT UNRESTRICTED AMOUNT | $71.2K | FY2024 | Mar 2024 – Mar 2026 |
| VA/DoDDepartment of Defense | ELEVON CONTROL POWER EFFECTIVE OF VTOL TAIL-SITTER IN HOVER MODE | $50K | FY2021 | Sep 2021 – Sep 2023 |
| Department of Homeland Security | RAIL AND TRANSIT SECURITY GRANT PROGRAM | $47.2K | FY2015 | Sep 2015 – Aug 2018 |
| Department of Agriculture | REAP ENERGY EFFICIENCY IMPROVEMENT (EEI) GRANT UNRESTRICTED AMOUNT | $42.8K | FY2025 | Dec 2024 – Dec 2026 |
| Department of Homeland Security | FY 2011 INTERCITY BUS SECURITY GRANT PROGRAM | $38.7K | FY2011 | Sep 2011 – Aug 2014 |
| Department of Transportation | LIFT REIMBURSEMENT | $29.1K | — | — – — |
| Department of Transportation | LIFT REIMBURSEMENT | $29.1K | FY2012 | Apr 2012 – May 2014 |
| Department of Agriculture | SEC. 9007 REAP-RENEW ENERGY SYS GRANTS (MAN) | $24.4K | FY2019 | May 2019 – May 2021 |
| Department of Agriculture | REAP RENEWABLE ENERGY SYSTEM (RES) GRANT $20K AND LESS | $10.7K | FY2023 | May 2023 – May 2025 |
| Department of Agriculture | SEC 9007 REAP-RENEW ENERGY SYSTEMS GRANTS, $20,000 OR LESS (MAN) | $2,788 | FY2012 | May 2012 – May 2014 |
| Department of Agriculture | WASTE DISPOSAL GRANTS - REGULAR | -$1M | FY2011 | Jun 2011 – Jun 2011 |
Department of Health and Human Services
$6.2M
ADVANCED THERAPEUTIC FOR PARKINSON'S DISEASE
Department of Health and Human Services
$3.5M
NOVEL DFG OUT INHIBITORS OF ABL-KINASES TO TREAT PML
Department of Health and Human Services
$2M
ADVANCED PRODRUG TREATMENT FOR CML
Department of Agriculture
$1.7M
WASTE DISPOSAL GRANTS - REGULAR
Department of Agriculture
$1M
WASTE DISPOSAL GRANTS - REGULAR
Department of Health and Human Services
$385.9K
KINASE ACTIVATION IN MULTIPLE SYSTEM ATROPHY - MULTIPLE SYSTEM ATROPHY (MSA) IS AN UNRELENTING NEURODEGENERATIVE DISORDER WITH AN UNCERTAIN ETIOLOGY AND PATHOPHYSIOLOGY. MSA IS A UNIQUE PROTEINOPATHY IN WHICH ALPHA-SYNUCLEIN ACCUMULATES PREFERENTIALLY IN OLIGODENDROGLIA RATHER THAN NEURONS. ACCUMULATED ALPHA-SYNUCLEIN, KNOWN AS A GLIAL CYTOPLASMIC INCLUSION (GCI), IS THOUGHT TO ELICIT CHANGES IN OLIGODENDROCYTE FUNCTION, SUCH AS REDUCED NEUROTROPHIC SUPPORT AND DEMYELINATION, LEADING TO NEURODEGENERATION. WE HAVE DEVELOPED NOVEL RAT AND NONHUMAN PRIMATE (NHP) MODELS OF MSA BY EXPRESSING ALPHA-SYNUCLEIN IN OLIGODENDROGLIA USING A NOVEL GLIALOLIGODENDROCYTE-TROPHIC ADENO-ASSOCIATED VIRUS (AAV) VECTOR, OLIG001. HISTOLOGICAL ANALYSIS SHOWED WIDESPREAD EXPRESSION OF OLIGO01- LINKED ALPHA-SYNUCLEIN THROUGHOUT THE STRIATUM AND CORPUS CALLOSUM IN RAT BRAIN WITH >90% LOCALIZED TO OLIGODENDROGLIA AND LITTLE TO NO EXPRESSION IN NEURONS OR ASTROCYTES. THE MODEL ALSO DISPLAYS DEMYELINATION IN THE WHITE MATTER TRACTS OF THE CORPUS CALLOSUM AND STRIATUM, SIMILAR TO WHAT IS OBSERVED IN PATIENT BRAIN. ANALYSIS OF GCIS FROM THE MODEL ANIMALS REVEALED THAT THEY CONTAIN DISEASE-SPECIFIC PHOSPHORYLATIONS AT TYR39 AND SER129 THAT ARE IDENTICAL TO THE MODIFICATIONS OF ALPHA-SYNUCLEIN SEEN IN NEURONS OF PARKINSON'S DISEASE (PD) PATIENTS. THE UNEXPECTED OBSERVATION OF THESE MODIFICATIONS IN MSA MODEL BRAIN WERE ALSO FOUND IN MSA PATIENT BRAIN (SEE INNOVATION) FURTHER VALIDATED THE SUITABILITY OF THIS RAT MODEL FOR THE STUDY OF DISEASE MECHANISM IN MSA. WHILE BOTH MSA AND PD ARE SYNUCLEINOPATHIES, IT HAS LONG BEEN THOUGHT THAT THE ORIGIN OF PATHOLOGY FOR THESE TWO DISEASES WERE DISTINCT. THE OBSERVATION OF DISEASE-SPECIFIC CHEMICAL MODIFICATIONS IN MSA THAT ARE IDENTICAL TO WHAT IS OBSERVED IN PD SUGGESTS A CLOSER MECHANISTIC LINKAGE BETWEEN THESE DISPARATE DISEASES. IN PARTICULAR, SINCE ACTIVATION OF THE ABELSON TYROSINE KINASE C-ABL IS A KEY DISEASE-INITIATING EVENT IN PD THAT RESULTS IN PHOSPHORYLATION AT TYR39, IT IS POSSIBLE THAT C-ABL PLAYS A SIMILAR ROLE IN MSA AND THAT CHEMICAL INHIBITION OF C- ABL COULD BE DISEASE-MODIFYING IN MSA. THIS SUGGESTS THAT TREATMENT FOR MSA MAY BE BENEFITED BY AN ORALLY BIOAVAILABLE, BRAIN-PENETRANT C-ABL KINASE INHIBITOR, JUST AS WE'VE SHOWN FOR PARKINSON'S DISEASE. USING THIS NEWLY DEFINED MODEL OF MSA, WE PROPOSE TO DETERMINE WHETHER MSA HAS THE SAME CRITICAL DEPENDENCY ON C-ABL ACTIVATION THAT HAS BEEN FOUND IN PD, PAVING THE WAY FOR DISEASE MODIFYING THERAPY.
Department of Health and Human Services
$303K
PML ANTIVIRAL FOR AIDS
Department of Health and Human Services
$300K
DFG-OUT INHIBITORS OF ABL-KINASES TO TREAT PML
Appalachian Regional Commission
$300K
SEWER SYSTEM (UPGRADE)
Department of Health and Human Services
$284.8K
PRODRUG TREATMENT FOR CML
Department of Agriculture
$256.1K
REAP ENERGY EFFICIENCY IMPROVEMENT (EEI) GRANT UNRESTRICTED AMOUNT
Department of Agriculture
$80K
REAP ENERGY EFFICIENCY IMPROVEMENT (EEI) GRANT UNRESTRICTED AMOUNT
Department of Transportation
$71.9K
1 RETROFIT AND 1 NEW LIFT
Department of Agriculture
$71.2K
REAP ENERGY EFFICIENCY IMPROVEMENT (EEI) GRANT UNRESTRICTED AMOUNT
Department of Defense
$50K
ELEVON CONTROL POWER EFFECTIVE OF VTOL TAIL-SITTER IN HOVER MODE
Department of Homeland Security
$47.2K
RAIL AND TRANSIT SECURITY GRANT PROGRAM
Department of Agriculture
$42.8K
REAP ENERGY EFFICIENCY IMPROVEMENT (EEI) GRANT UNRESTRICTED AMOUNT
Department of Homeland Security
$38.7K
FY 2011 INTERCITY BUS SECURITY GRANT PROGRAM
Department of Transportation
$29.1K
LIFT REIMBURSEMENT
Department of Transportation
$29.1K
LIFT REIMBURSEMENT
Department of Agriculture
$24.4K
SEC. 9007 REAP-RENEW ENERGY SYS GRANTS (MAN)
Department of Agriculture
$10.7K
REAP RENEWABLE ENERGY SYSTEM (RES) GRANT $20K AND LESS
Department of Agriculture
$2,788
SEC 9007 REAP-RENEW ENERGY SYSTEMS GRANTS, $20,000 OR LESS (MAN)
Department of Agriculture
-$1M
WASTE DISPOSAL GRANTS - REGULAR
Source: Federal Audit Clearinghouse (fac.gov)
No federal single audit records found for this organization.
Single audits are required for entities expending $750,000+ in federal awards annually.
Source: IRS e-Filed Form 990
No officer or director compensation data available for this organization.
This data is sourced from IRS Form 990, Part VII. It may not be available if the organization files Form 990-N (e-Postcard) or has not yet been enriched.
Source: IRS Publication 78, Auto-Revocation List & e-Postcard Data
Tax-deductible contributions: Yes
Deductibility code: PC
Sources: IRS e-Filed Form 990 (XML) & ProPublica Nonprofit Explorer
Scroll →
| Year | Revenue | Contributions | Expenses | Assets | Net Assets |
|---|---|---|---|---|---|
| 2023 | $40.5K | — | $44.3K | $9,247 | — |
| 2022 | $57.6K | — | $47.9K | $13K | — |
| 2021 | $25.5K | — | $29.5K | $3,324 | — |
| 2020 | $26.7K | — | $23.3K | $7,262 | — |
Sources: ProPublica Nonprofit Explorer & IRS e-File Index
Financial data: IRS Form 990 via ProPublica Nonprofit Explorer (Tax Year 2023)
Federal grants: USAspending.gov (live)
Organization info: IRS Business Master File · ProPublica Nonprofit Explorer
Tax-deductibility: IRS Publication 78
| 2019 | $22.9K | — | $22.2K | $3,928 | — |
| 2018 | $25.1K | — | $28.9K | $3,228 | — |
| 2017 | $12.2K | — | $20.1K | $7,058 | — |
| 2016 | $35.5K | — | $24.7K | $15K | — |
| 2015 | $24.7K | — | $24.2K | $4,215 | — |
| 2014 | $26.5K | — | $29.5K | $3,642 | — |
| 2013 | $30.1K | — | $31.9K | $6,648 | — |
| 2012 | $33.8K | — | $58.3K | $8,441 | — |
| 2011 | $50.2K | — | $59.2K | $34.9K | — |
| 2021 | 990-EZ | Data | PDF not yet published by IRS |
| 2020 | 990-EZ | Data | PDF not yet published by IRS |
| 2019 | 990-EZ | Data |
| 2018 | 990-EZ | Data |
| 2017 | 990-EZ | Data |
| 2016 | 990-EZ | Data |
| 2015 | 990-EZ | Data |
| 2014 | 990-EZ | Data |
| 2013 | 990-EZ | Data |
| 2012 | 990-EZ | Data |
| 2011 | 990-EZ | Data |
| 2010 | 990-EZ | — |
| 2009 | 990-EZ | — |