Andson Inc

FOSTER GRANDPARENT PROGRAM

DEVELOPMENT OF AN AUTOMATED SAMPLE PREPARATION PLATFORM FOR HIGH THROUGHPUT MASS SPECTROMETRY CHARACTERIZATION OF BIOTHERAPEUTICS - PROJECT SUMMARY/ABSTRACT BIOTHERAPEUTICS REPRESENT THE FASTEST-GROWING PHARMACEUTICAL SEGMENT, OFFERING TRANSFORMATIVE TREATMENTS FOR PREVIOUSLY INTRACTABLE DISEASES LIKE CANCER AND GENETIC DISORDERS. HOWEVER, THESE COMPLEX BIOTHERAPEUTICS FACE SIGNIFICANT ANALYTICAL CHALLENGES RESULTING IN EXTENDED DEVELOPMENT TIMELINES AND HIGH COSTS, DIRECTLY LIMITING PATIENT ACCESS. MODERN BIOTHERAPEUTICS AND EMERGING MODALITIES ARE INCREASINGLY LARGE AND STRUCTURALLY COMPLEX, REQUIRING MORE SOPHISTICATED CHARACTERIZATION TECHNIQUES TO ASSESS CRITICAL QUALITY ATTRIBUTES IMPACTING SAFETY AND EFFICACY. MASS SPECTROMETRY (MS) SERVES AS THE GOLD STANDARD FOR BIOTHERAPEUTIC CHARACTERIZATION. WHILE TRADITIONAL MS APPROACHES DENATURE PROTEINS DURING ANALYSIS, ADVANCED MS TECHNIQUES LIKE NATIVE MS (NMS) AND CHARGE DETECTION MS (CDMS) PRESERVE AND ANALYZE INTACT, BIOLOGICALLY RELEVANT STRUCTURES WHILE EXTENDING CAPABILITIES INTO THE MEGADALTON RANGE. THESE NATIVE-LIKE ANALYSES PROVIDE CRITICAL INSIGHTS ESSENTIAL FOR UNDERSTANDING THERAPEUTIC EFFICACY AND SAFETY. BOTH TECHNIQUES RELY ON NANO-ELECTROSPRAY IONIZATION (NESI), WHICH PRESERVES DELICATE BIOLOGIC STRUCTURES WITH ENHANCED IONIZATION EFFICIENCY. WHILE NEARLY ALL FDA BIOLOGICS APPLICATIONS USE MS, FEW UTILIZE NMS OR CDMS DUE TO TECHNICAL COMPLEXITY OF NESI AND LABOR-INTENSIVE SAMPLE PREPARATION, REDUCING REPRODUCIBILITY AND THROUGHPUT AND SEVERELY LIMITING ADOPTION DESPITE THEIR ADVANCED CAPABILITIES. THIS PROPOSAL ADDRESSES CRITICAL BARRIERS BY DEVELOPING ANDSON BIOTECH'S AUTO-DYNACHIP PLATFORM - A COMPACT SYSTEM INTEGRATING AUTOSAMPLER CAPABILITIES WITH IN-LINE MICROFLUIDIC SAMPLE PREPARATION FOR STREAMLINED NESI TO ENABLE HIGH-THROUGHPUT NMS AND CDMS ANALYSIS. BUILDING ON ANDSON'S EXISTING DYNACHIP X1, THE FIRST COMMERCIALLY AVAILABLE SYSTEM COUPLING RAPID MICROFLUIDIC SAMPLE CLEANUP WITH NESI, THE AUTO- DYNACHIP WILL TRANSFORM BIOPHARMACEUTICAL WORKFLOWS BY BRIDGING HIGH-THROUGHPUT NEEDS WITH NATIVE CHARACTERIZATION OF LARGE BIOMOLECULES. THE SYSTEM FEATURES ADVANCED MICROFLUIDICS ENABLING: (1) AUTOMATED SAMPLE CLEANUP AND BUFFER EXCHANGE IN MINUTES, (2) PRECISE DIGITAL FLOW CONTROL FOR CONSISTENT NESI OPERATION, AND (3) OPTIMIZED DELIVERY FOR DIRECT MS COUPLING. AIM 1 WILL DEVELOP APPLICATION-SPECIFIC MICROFLUIDIC CHIP DESIGNS AND ROBUST MANUFACTURING PROCESSES, OPTIMIZING CHANNEL GEOMETRY AND MEMBRANE PARAMETERS FOR VARIOUS PROTEIN TARGETS. AIM 2 WILL INTEGRATE AUTOSAMPLER CAPABILITIES FOR HIGH-THROUGHPUT WORKFLOWS, ENABLING AUTOMATED SAMPLE PROCESSING WITH MINIMAL INTERVENTION WHILE MAINTAINING STABLE NESI PERFORMANCE. AIM 3 WILL VERIFY AND VALIDATE CONSUMABLES AND THE COMMERCIAL INSTRUMENT THROUGH INTERNAL TESTING AND CROSS-LABORATORY VALIDATION USING STANDARDIZED PROTOCOLS AND REFERENCE MATERIALS. THE SUCCESSFUL DEVELOPMENT OF THE AUTO-DYNACHIP WILL ADDRESS A CRITICAL TECHNOLOGICAL GAP IN BIOTHERAPEUTICS CHARACTERIZATION WHILE ADVANCING THE BROADER FIELDS OF MICROFLUIDICS AND BIOANALYTICAL CHEMISTRY. BY ENABLING UNPRECEDENTED HIGH-THROUGHPUT ADVANCED MS ANALYSIS, LIKE NMS AND CDMS, THIS INNOVATION WILL ACCELERATE DEVELOPMENT TIMELINES, REDUCE COSTS, AND ENHANCE DATA QUALITY, ULTIMATELY EXPANDING PATIENT ACCESS TO TRANSFORMATIVE MEDICINES.

FOSTER GRANDPARENT PROGRAM

ENGAGES PERSONS 55 AND OLDER IN SUPPORTIVE SERVICE TO CHILDREN IN NEED

THIS AWARD APPROVES FUNDING FOR THE 2023-24 VOLUNTEER GENERATION FUND ARP PROGRAM DESCRIBED IN THE APPROVED PROGRAM NARRATIVE AND BUDGET. THE PURPOSE OF THIS GRANT IS TO SUPPORT 150 ORGANIZATIONS IN ALIGNMENT WITH THE VGF FOCUS AREAS OF HIGH IMPACT TUTORING AND MENTORING, REMOVING RACIAL INEQUITIES AND INCREASING OPPORTUNITY, VOLUNTEER CAPACITY BUILDING, PROFESSIONALISM OF VOLUNTEER ENGAGEMENT, SKILLS-BASED, AND PRO-BONO VOLUNTEERISM, AND MEETING ADDITIONAL PRESSING COMMUNITY NEEDS. BY PERFORMING THE FOLLOWING HIGH LEVEL ACTIVITIES: SUPPORT INCREASED CAPACITY FOR VOLUNTEER MANAGEMENT BY PROVIDING TRAINING, WEBINARS, COMMUNITIES OF PRACTICE, AND TECHNICAL ASSISTANCE, THIS WILL BENEFIT 150 ORGANIZATIONS AND 250 STUDENTS. THE GENERAL EXPECTED OUTCOME INCLUDES INCREASING THE EFFECTIVENESS OF VOLUNTEER MANAGEMENT PRACTICES AND BUILDING ORGANIZATIONAL CAPACITY OF ORGANIZATIONS AND IMPROVING ACADEMIC ENGAGEMENT OR SOCIAL-EMOTIONAL SKILLS OF STUDENTS. YOUR 2023-24 REGULATORY MATCH IS 20%, AND YOUR BUDGETARY MATCH IS 35.7%.

RETIRED AND SENIOR VOLUNTEER PROGRAM

HANDSON SUBURBAN CHICAGO (HOSC) HAS SERVED AS THE SPONSORING AGENCY OF THE SENIOR CORPS-RSVP OF NORTHERN COOK AND NORTHERN DUPAGE COUNTIES SINCE 1992. AN ESTIMATED 725 RSVP MEMBERS WILL SERVE. OF THIS NUMBER, 260 RSVP VOLUNTEERS WILL BE PLACED IN OUTCOME ASSIGNMENTS. SOME OF THEIR ACTIVITIES WILL INCLUDE: TUTORING ELEMENTARY AND MIDDLE SCHOOL STUDENTS; PROVIDING OTHER CLASSROOM SUPPORT OF BILINGUAL AND ENGLISH LANGUAGE LEARNER(ELL) STUDENTS THROUGH OUR INTERGENERATIONAL PEN PAL PROGRAM; JOB READINESS AND OTHER SKILL DEVELOPMENT FOR ADULT ELL STUDENTS; TRANSPORTATION FOR OLDER ADULTS TO MEDICAL APPOINTMENTS; REPAIR AND PAINT THE EXTERIOR OF HOMES OF ELIGIBLE SENIORS, VETERANS OR PEOPLE WITH DISABILITIES; AND IMPROVED FINANCIAL LITERACY AND TAX PREPARATION. THE PRIMARY FOCUS AREA OF THE PROJECT IS EDUCATION. AT THE END OF THE THREE YEAR GRANT: (1) THROUGH TUTORING PROGRAMS, 260 ELEMENTARY AND MIDDLE SCHOOL STUDENTS WILL DEMONSTRATE IMPROVED ACADEMIC ENGAGEMENT OR SOCIAL EMOTIONAL SKILLS; (2) THROUGH THE INTERGENERATIONAL PEN PAL PROGRAM, 55 STUDENTS WILL DEMONSTRATE IMPROVED ACADEMIC ENGAGEMENT OR SOCIAL-EMOTIONAL SKILLS; (3) 8 ADULT ELL STUDENTS WILL SHOW IMPROVED JOB READINESS;(4) 67 INDIVIDUALS WILL RECEIVE TRANSPORTATION SERVICES RESULTING IN IMPROVED ACCESS TO MEDICAL CARE; (5) 6 HOMES OF AN ELIGIBLE SENIOR, VETERAN, OR PERSON WITH DISABILITIES WILL BE PAINTED OR REPAIRED RESULTING IN A TRANSITION TO SAFE, HEALTHY AND AFFORDABLE HOUSING; AND (6) 750 ELIGIBLE INDIVIDUALS WILL RECEIVE NO CHARGE TAX PREPARATION AND FINANCIAL LITERACY ASSISTANCE, RESULTING IN A TOTAL OF APPROXIMATELY $755,000 IN TAX REFUNDS TO CLIENTS. THE CNCS FEDERAL INVESTMENT OF $187,618 WILL BE SUPPLEMENTED BY NON-FEDERAL RESOURCES OF $95,673.

THIS AWARD FUNDS THE APPROVED 2023-24 RSVP PROGRAM. YOUR 2023-24 STATUTORY MATCH IS 30% AND YOUR BUDGETARY MATCH IS 33.48%.

ENGAGES PERSONS 55 AND OLDER IN VOLUNTEER SERVICE IN THEIR COMMUNITIES

HANDSON SUBURBAN CHICAGO HAS SERVED AS THE SPONSORING AGENCY OF THE RSVP OF NORTHERN COOK AND NORTHERN DUPAGE COUNTIES SINCE 1992. AN ESTIMATED 725 RSVP VOLUNTEERS WILL SERVE. OF THIS NUMBER, 182 WILL BE PLACED IN OUTCOME ASSIGNMENTS. SOME OF THEIR ACTIVITIES WILL INCLUDE TUTORING AND MENTORING ELEMENTARY AND MIDDLE AGED STUDENTS; ACTING AS A PEN PAL FOR LOCAL ELEMENTARY SCHOOL STUDENTS; ASSISTING WITH SERVICE LEARNING ACTIVITIES FOR LOCAL HIGH SCHOOL STUDENTS; PROVIDING TRANSPORTATION FOR OLDER ADULTS TO MEDICAL APPOINTMENTS; REPAIRING AND PAINTING THE EXTERIOR OF HOMES OF ELIGIBLE SENIORS, VETERANS OR PEOPLE WITH DISABILITIES; AND HELPING WITH TAX PREPARATION. THE PRIMARY FOCUS AREA OF THE PROJECT IS EDUCATION. AT THE END OF THE THREE YEAR GRANT: (1) THROUGH TUTORING AND MENTORING PROGRAMS, 350 ELEMENTARY AND MIDDLE SCHOOL STUDENTS WILL DEMONSTRATE IMPROVED ACADEMIC ENGAGEMENT; (2) THROUGH THE PEN PAL PROGRAM, 40 STUDENTS WILL DEMONSTRATE IMPROVED ACADEMIC ENGAGEMENT; (3) 20 HIGH SCHOOL STUDENTS WILL SHOW IMPROVED ACADEMIC ENGAGEMENT; (4) 67 INDIVIDUALS WILL RECEIVE TRANSPORTATION SERVICES RESULTING IN THEIR REPORTING INCREASED SOCIAL TIES AND PERCEIVED SOCIAL SUPPORT; (5) FIFTEEN HOMES OF AN ELIGIBLE SENIOR, VETERAN, OR PERSON WITH DISABILITIES WILL BE PAINTED OR REPAIRED; AND (6) 793 ELIGIBLE INDIVIDUALS WILL RECEIVE NO CHARGE TAX PREPARATION ASSISTANCE, RESULTING IN APPROXIMATELY $158,600 WORTH OF SAVINGS IN TAX PREPARATION FEES. THE CNCS FEDERAL INVESTMENT OF $180,118 WILL BE SUPPLEMENTED BY NON-FEDERAL RESOURCES OF $77,193.

RETIRED AND SENIOR VOLUNTEER PROGRAM

ESTIMATED TOTAL FUNDS REFER TO THE FUNDS AVAILABLE FOR CASH GRANTS WHILE ESTIMATED NUMBER OF GRANTS EQUALS TOTAL OF ALL AMERICORPS VISTA PROJECTS, TH

A REAL-TIME MASS SPECTROMETRY PLATFORM FOR IN-PROCESS MONITORING AND CELL STATE ANALYSIS - PROJECT SUMMARY/ABSTRACT ADVANCED CELL THERAPIES OFFER LIFE-SAVING BENEFITS TO PATIENTS; HOWEVER, THEY ARE LIMITED BY VARIABLE QUALITY AND EFFICACY THAT RESULTS IN INCONSISTENT TREATMENT OUTCOMES. THESE CHALLENGES ARISE FROM DIFFICULTIES IN IDENTIFYING AND CONTROLLING KEY FACTORS THAT INFLUENCE THE FINAL PRODUCT’S THERAPEUTIC POTENTIAL, COUPLED WITH THE COMPLEXITY OF HOW THE FINAL PRODUCT WILL INTERACT WITHIN EACH PATIENT’S UNIQUE BIOLOGICAL LANDSCAPE. CURRENT CELL MANUFACTURING PROCESSES OFTEN RELY ON OFF-LINE, ENDPOINT ASSAYS FOR CELL STATE ANALYSIS AND RELEASE CRITERIA, WHICH PROVIDE LIMITED REAL-TIME, IN-PROCESS INSIGHTS INTO CRITICAL PROCESS PARAMETERS (CPPS) AND QUALITY ATTRIBUTES (CQAS) PREDICTIVE OF FINAL QUALITY AND EFFICACY. IN PART, THIS IS DUE TO A VOID IN EXISTING PROCESS ANALYTICAL TECHNOLOGIES (PATS) CAPABLE OF REAL-TIME DISCOVERY AND MEASUREMENT OF CPPS/CQAS. PATS WITH THIS CAPABILITY COULD FACILITATE IN-PROCESS ADJUSTMENT AND ALLOW FOR DEEPER, TEMPORAL INSIGHTS INTO BIOLOGICAL PROCESSES. IN ADDITION, CURRENT ASSAYS FOCUS ON BASIC QUALITY METRICS OF THE CELL PRODUCT (E.G., VIABILITY, PROLIFERATION, SURFACE MARKERS, ETC.) AND NEGLECT THE ROLE OF THE PATIENT’S UNIQUE BIOLOGY ON EFFICACY AND OUTCOMES. TOOLS AND ASSAYS THAT CAN IMPROVE UNDERSTANDING OF PRODUCT QUALITY AND PATIENT EFFICACY COULD DRASTICALLY IMPROVE BIOTHERAPEUTICS MANUFACTURING. MASS SPECTROMETRY (MS), IN PARTICULAR ELECTROSPRAY IONIZATION MS (ESI-MS), IS A PROMISING PAT FOR REAL-TIME MEASUREMENT OF CPPS/CQAS DUE TO A UNIQUE COMBINATION OF PICOMOLAR SENSITIVITY AND UNTARGETED, MULTI-ANALYTE SPECIFICITY WHILE STILL PRESERVING BIOCHEMICAL STRUCTURE. HOWEVER, ESI-MS FOR BIOLOGICAL SPECIMENS IS LIMITED BY THE NEED FOR EXTENSIVE OFF-LINE SAMPLE PREPARATION BEFORE MS AND TIME-CONSUMING, COMPLEX DATA PROCESSING AFTER MS, PRECLUDING REAL-TIME MONITORING. THEREFORE, THIS WORK AIMS TO DEVELOP AN INNOVATIVE PLATFORM TOOL THAT INTEGRATES WITH ANY ESI-MS SYSTEM FOR AT-LINE, REAL-TIME MEASUREMENT OF MEDIA BIOMOLECULES (E.G., CELL SECRETOME AND MEDIA ADDITIVES) FOR CPP/CQA DISCOVERY AND MONITORING. OUR PREVIOUSLY DEVELOPED MICROFLUIDIC CHIP PROVIDES SIMPLIFIED SAMPLE PREPARATION, WHILE AN IN-DEVELOPMENT SOFTWARE INTERFACE GENERATES CRITICAL PROCESS INSIGHT FROM ESI-MS DATA WITHIN MINUTES, ADDRESSING BOTH SAMPLE PREPARATION AND DATA ANALYTICS CHALLENGES. DURING PHASE I, A PROTOTYPE DEVICE WITH INTEGRATED COMPONENTS (INCUBATOR, LIQUID HANDLER, AND THE MICROFLUIDIC SAMPLE PREPARATION DEVICE) WILL BE FABRICATED AND EVALUATED USING PROOF-OF-CONCEPT MSC-BASED TEST BEDS FOR CELL MANUFACTURING IN-PROCESS MONITORING AND FOR RAPID, PATIENT-SPECIFIC DONOR CELL SCREENING. THIS WILL DEMONSTRATE REAL-TIME MONITORING OF CELL MEDIA BIOMOLECULES, GIVING PREVIOUSLY UNATTAINABLE TEMPORAL INSIGHTS INTO CELL STATE THROUGHOUT EVERY STAGE OF DEVELOPMENT. PHASE II WILL EXPAND THIS REAL-TIME MONITORING TECHNOLOGY FOR SCALABLE APPLICATIONS (I.E., BIOREACTORS, NON-ADHERENT CELLS) AND DEVELOP A COMMERCIAL-GRADE SOFTWARE INTERFACE FOR AUTOMATED REAL-TIME DATA EXTRACTION AND PROCESS FEEDBACK CONTROL. SUCCESSFUL DEVELOPMENT OF THIS TOOL WILL PAVE THE WAY FOR NEW PROGRESS IN DRUG DISCOVERY AND PROCESS DEVELOPMENT, INCLUDING IMPROVED CPP/CQA DISCOVERY AND MONITORING, ULTIMATELY IMPROVING CELL THERAPY MANUFACTURING AND PATIENT OUTCOMES.

THIS AWARD FUNDS THE APPROVED 2026-27 AMERICORPS SENIORS RSVP PROGRAM. YOUR 2026-27 STATUTORY MATCH REQUIREMENT IS 10% AND YOUR BUDGETED MATCH IS 25.12%. YOU ARE APPROVED FOR PRE-AWARD COSTS BEGINNING 30 DAYS PRIOR TO AWARD.

ENGAGES PERSONS 55 AND OLDER IN VOLUNTEER SERVICE IN THEIR COMMUNITIES

RETIRED AND SENIOR VOLUNTEER PROGRAM

RETIRED AND SENIOR VOLUNTEER PROGRAM

ENGAGES PERSONS 55 AND OLDER IN VOLUNTEER SERVICE IN THEIR COMMUNITIES

ENGAGES PERSONS 55 AND OLDER IN VOLUNTEER SERVICE IN THEIR COMMUNITIES

ENGAGES PERSONS 55 AND OLDER IN VOLUNTEER SERVICE IN THEIR COMMUNITIES

VISTA STATE

VISTA STATE

REAP RENEWABLE ENERGY SYSTEM (RES) GRANT UNRESTRICTED AMOUNT

SEC 9007 REAP-RENEW ENERGY SYSTEMS GRANTS, $20,000 OR LESS (MAN)