Hope

DESCRIPTION:NOTE: A SPECIAL PAYMENT CONDITION APPLIES TO THIS AWARD. THIS AGREEMENT PROVIDES FUNDING UNDER THE INFLATION REDUCTION ACT. THE RECIPIENT WILL PROVIDE FINANCIAL AND TECHNICAL ASSISTANCE TO LOW-INCOME AND DISADVANTAGED COMMUNITIES TO DEPLOY AND BENEFIT FROM RESIDENTIAL-SERVING DISTRIBUTED SOLAR ENERGY AND STORAGE PROJECTS. THESE PROGRAMS WILL ENSURE LOW-INCOME HOUSEHOLDS RECEIVE RESIDENTIAL DISTRIBUTED SOLAR BY PROVIDING PROGRAM BENEFICIARIES HOUSEHOLD SAVINGS, COMMUNITY OWNERSHIP, ENERGY RESILIENCE, AND OTHER MEANINGFUL BENEFITS. ACTIVITIES:SOLAR PROJECTS RECEIVING FINANCIAL ASSISTANCE FROM THE RECIPIENT MAY RECEIVE ASSISTANCE FOR ASSOCIATED ENERGY STORAGE AND UPGRADES THAT EITHER ENABLE PROJECT DEPLOYMENT OR MAXIMIZE THE BENEFITS OF THE PROJECT FOR LOW-INCOME AND DISADVANTAGED COMMUNITIES. THE RECIPIENT WILL ALSO PROVIDE PROJECT-DEPLOYMENT SERVICES TO ENABLE LOW-INCOME AND DISADVANTAGED COMMUNITIES TO DEPLOY AND BENEFIT FROM RESIDENTIAL SOLAR.SUBRECIPIENT:NO SUBAWARDS ARE INCLUDED IN THIS ASSISTANCE AGREEMENT.OUTCOMES:THE ANTICIPATED DELIVERABLES WILL INCLUDE STEPS AND MILESTONES TO IMPLEMENT THE STRATEGIES AND PLANS FOR THE SOLAR FOR ALL PROGRAM, A DISTRIBUTE SOLAR MARKET STRATEGY, THE FINANCIAL ASSISTANCE STRATEGY, THE PROJECT-DEPLOYMENT TECHNICAL ASSISTANCE STRATEGY, AND AN EQUITABLE ACCESS AND MEANINGFUL INVOLVEMENT PLAN. THE EXPECTED OUTCOMES INCLUDE CLIMATE AND AIR POLLUTION BENEFITS, EQUITY AND COMMUNITY BENEFITS, AND MARKET TRANSFORMATION BENEFITS. THE INTENDED BENEFICIARIES INCLUDE HOUSEHOLDS IN LOW-INCOME AND DISADVANTAGED COMMUNITIES.

THE GOAL OF THE CORE ACTIVITY IS TO REDUCE NEW HIV INFECTIONS AND HIV MORBIDITY AND MORTALITY RATES IN MALAWI THROUGH INCREASING ACCESS TO AND UTILIZATION OF HIGH-QUALITY, COMPREHENSIVE SERVICES ACROSS THE CONTINUUM OF HIV TREATMENT AND CARE WITHIN THE SUB-NATIONAL UNITS (SNUS) OR DISTRICTS WHERE IT OPERATES.

CANCER CENTER SUPPORT GRANT

DESCRIPTION:THIS AGREEMENT PROVIDES FUNDING UNDER THE INFLATION REDUCTION ACT. THE RECIPIENT WILL PROVIDE FINANCIAL AND TECHNICAL ASSISTANCE TO LOW-INCOME AND DISADVANTAGED COMMUNITIES TO DEPLOY AND BENEFIT FROM RESIDENTIAL-SERVING DISTRIBUTED SOLAR ENERGY AND STORAGE PROJECTS. THESE PROGRAMS WILL ENSURE LOW-INCOME HOUSEHOLDS RECEIVE RESIDENTIAL DISTRIBUTED SOLAR BY PROVIDING PROGRAM BENEFICIARIES HOUSEHOLD SAVINGS, COMMUNITY OWNERSHIP, ENERGY RESILIENCE, AND OTHER MEANINGFUL BENEFITS. ACTIVITIES:SOLAR PROJECTS RECEIVING FINANCIAL ASSISTANCE FROM THE RECIPIENT MAY RECEIVE ASSISTANCE FOR ASSOCIATED ENERGY STORAGE AND UPGRADES THAT EITHER ENABLE PROJECT DEPLOYMENT OR MAXIMIZE THE BENEFITS OF THE PROJECT FOR LOW-INCOME AND DISADVANTAGED COMMUNITIES. THE RECIPIENT WILL ALSO PROVIDE PROJECT-DEPLOYMENT SERVICES TO ENABLE LOW-INCOME AND DISADVANTAGED COMMUNITIES TO DEPLOY AND BENEFIT FROM RESIDENTIAL SOLAR.SUBRECIPIENT:NO SUBAWARDS ARE INCLUDED IN THIS ASSISTANCE AGREEMENT.OUTCOMES:THE ANTICIPATED DELIVERABLES WILL INCLUDE STEPS AND MILESTONES TO IMPLEMENT THE STRATEGIES AND PLANS FOR THE SOLAR FOR ALL PROGRAM, A DISTRIBUTE SOLAR MARKET STRATEGY, THE FINANCIAL ASSISTANCE STRATEGY, THE PROJECT-DEPLOYMENT TECHNICAL ASSISTANCE STRATEGY, AND AN EQUITABLE ACCESS AND MEANINGFUL INVOLVEMENT PLAN. THE EXPECTED OUTCOMES INCLUDE CLIMATE AND AIR POLLUTION BENEFITS, EQUITY AND COMMUNITY BENEFITS, AND MARKET TRANSFORMATION BENEFITS. THE INTENDED BENEFICIARIES INCLUDE HOUSEHOLDS IN LOW-INCOME AND DISADVANTAGED COMMUNITIES.

EARLY HEAD START AND HEAD START

HEALTH CENTER CLUSTER

DREAMS/TWAGAMENWA ACTIVITY

HEALTH CENTER CLUSTER

FULL YEAR PART DAY HEAD START AND SERVICES TO THE HANDICAPPED

HEALTH CENTER CLUSTER

HEALTH CENTER CLUSTER

HEAD START AND EARLY HEAD START

BUILDING HOPE'S FIVE INITIATIVES FOR CREDIT ENHANCEMENT PROGRAM

NAMIBIA ADHERENCE AND RETENTION PROJECT

PURPOSE: CONSTRUCT TERMINAL BUILDING. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT CONSTRUCTS A 355,000 SQUARE FOOT TERMINAL BUILDING TO MEET DESIGN STANDARDS. THIS GRANT FUNDS 65.54% OF THE DESIGN. THIS PROJECT IS ASSOCIATED WITH A BIPARTISAN INFRASTRUCTURE LAW AIRPORT INFRASTRUCTURE GRANT THAT FUNDS THE REMAINING ELIGIBLE PORTION OF THE PROJECT. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH BURBANK, CALIFORNIA.

NEW COOPERATIVE AGREEMENT FOR USAID COMMUNITY HIV AND AIDS CARE AND TREATMENT ACTIVITY; INITIAL OBLIGATE $4,000,000 .

CITY OF HOPE LYMPHOMA SPORE

THE HUMAN ISLET DISTRIBUTION COORDINATING CENTER (UC4)

THE OBJECTIVE OF THIS ASSISTANCE ACTIVITY IS TO SUPPORT A RECIPIENT TO ACCELERATE PROGRESS TOWARD HIV EPIDEMIC CONTROL IN MALAWI THROUGH IMPLEMENTATION OF COST-EFFECTIVE AND INNOVATIVE INTERVENTIONS TO INCREASE HUMAN IMMUNODEFICIENCY VIRUS (HIV) CASE FINDING, LINKAGE TO TREATMENT FOR HIV, AND VIRAL LOAD SUPPRESSION AMONG PEOPLE LIVING WITH HIV (PLHIV).

HEAD START AND EARLY HEAD START

NETHOPE - EXPAND USE OF BROADBAND INTERNET TO PROVIDE RURAL CONNECTIVITY IN THE DEVELOPING WORLD.

IMPROVE EXISTING AIRPORT

PURPOSE: AMERICAN RESCUE PLAN ACT AWARDED AS ECONOMIC ASSISTANCE TO ELIGIBLE U.S. AIRPORTS AND ELIGIBLE CONCESSIONS AT THOSE AIRPORTS TO PREVENT, PREPARE FOR, AND RESPOND TO THE COVID-19 PANDEMIC. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS GRANT PROVIDES ECONOMIC RELIEF FUNDS FOR COSTS RELATED TO OPERATIONS, PERSONNEL, CLEANING, SANITIZATION, JANITORIAL SERVICES, DEBT SERVICE PAYMENTS, AND COMBATING THE SPREAD OF PATHOGENS AT THE AIRPORT. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH BURBANK, CALIFORNIA.

INNOVATIVE INFRASTRUCTURE TO ENHANCE THE CALIFORNIA TEACHERS STUDY

ANA NDI ACHINYAMATA PATSOGOLO A NEW ORPHAN AND VULNERABLE CHILDREN ACTIVITY TO PREVENT NEW HIV INFECTIONS AND IMPROVE THE HEALTH, WELL-BEING, AND PROTECTION OF CHILDREN, ADOLESCENTS AND YOUNG WOMEN

GH16-1717: INCREASING ACCESS TO AND AVAILABILITY OF SUSTAINABLE, HIGH QUALITY, COMPREHENSIVE HEALTH

PARTNERS IN HOPE (PIH) MEDICAL CENTER AND ITS PARTNERS PROPOSE TO COLLABORATE WITH CHRISTIAN HOSPITAL ASSOCIATION OF MALAWI (CHAM) TO ACHIEVE THE FOL

HEALTH CENTER CLUSTER

PHASE I MOLECULAR AND CLINICAL PHARMACODYNAMIC TRIALS ET-CTN

COTE D'IVOIRE EXPANDED RESPONSE TO AIDS (CIERA)

THE PURPOSE OF THIS COOPERATIVE AGREEMENT IS TO AVERT NEW INFECTIONS FOR CHILDREN AND YOUTH AND IMPROVE TREATMENT OUTCOMES FOR HIV POSITIVE CHILDREN AND ADOLESCENTS BY INCREASING ACCESS TO COMPREHENSIVE HIV PREVENTION AND IMPACT MITIGATION SERVICES AND STRENGTHENING RESILIENCE IN VULNERABLE CHILDREN, ADOLESCENTS, AND YOUTH,

PURPOSE: CONSTRUCT TERMINAL. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT CONSTRUCTS A 355,000 SQUARE FOOT TERMINAL BUILDING TO MEET DESIGN POLICY STANDARDS. THIS GRANT FUNDS THE SECOND PHASE, WHICH CONSISTS OF THE CONSTRUCTION OF THE TERMINAL BUILDING STEEL. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH BURBANK, CALIFORNIA.

HEALTH CENTER CLUSTER

THIS IS A COOPERATIVE AGREEMENT TO NEW PARTNER HOPE WORLDWIDE NIGERIA UNDER THE PEPFAR PROGRAM. THE INITIAL OBLIGATION IS $893 293.50 AND THE TOTAL

HEALTH CENTER CLUSTER

PURPOSE: CONSTRUCT TERMINAL BUILDING. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT CONSTRUCTS A 355,000 SQUARE FOOT TERMINAL BUILDING TO MEET DESIGN STANDARDS. THIS GRANT FUNDS 34.46% OF THE DESIGN. THIS PROJECT IS ASSOCIATED WITH A BIPARTISAN INFRASTRUCTURE LAW AIRPORT TERMINAL PROGRAM COMPANION GRANT THAT FUNDS THE REMAINING ELIGIBLE PORTION OF THE PROJECT. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH BURBANK, CALIFORNIA.

BOOSTING COMMUNITY BASED INDEX TESTING IN ZAMBIA (BCBIT-Z)

INTEGRATED ISLET DISTRIBUTION PROGRAM (U24) - 2021 - PROJECT SUMMARY / ABSTRACT HUMAN PANCREATIC ISLETS ARE AN ESSENTIAL RESEARCH RESOURCE FOR RESEARCH ON THE PREVENTION, TREATMENT, AND PATHOPHYSIOLOGY OF DIABETES MELLITUS. RECENT DATA HAVE HIGHLIGHTED IMPORTANT DIFFERENCES BETWEEN MURINE AND HUMAN ISLETS, SUBSTANTIATING THE CONTINUED NEED FOR ACCESS TO HUMAN ISLETS, AS THE GOLD STANDARD IN DIABETES RESEARCH. CITY OF HOPE (COH) IS APPLYING FOR THIS U24 RENEWAL TO REMAIN AS THE INTEGRATED ISLET DISTRIBUTION PROGRAM COORDINATING CENTER (IIDP CC) FOR THE NEXT 5 YEARS, TO CONTINUE TO PROVIDE DISTRIBUTION OF HUMAN CADAVERIC ISLETS AND ANCILLARY TISSUE FOR BIOMEDICAL RESEARCH TO RESEARCHERS WORLDWIDE. OUR PROPOSAL LEVERAGES THE SIGNIFICANT INVESTMENT MADE BY NIH OVER THE LAST 19 YEARS THAT HAS ESTABLISHED AND SUCCESSFULLY MAINTAINED THE IIDP AT COH. FROM QUALIFICATION AND AUDITING OF HIGH-QUALITY ISLET ISOLATION CENTERS (IICS), TO FORECASTING, TRACKING, AND MEETING THE NEEDS OF INVESTIGATORS, SINCE 2002 OUR EXPERIENCED TEAM HAS WORKED WITH 20 DIFFERENT ISLET ISOLATION LABORATORIES TO COORDINATE THE DISTRIBUTION OF OVER 330 MILLION ISLET EQUIVALENTS TO MORE THAN 400 INVESTIGATORS ACROSS 16 COUNTRIES SINCE 2002, SUPPORTING 767 PEER REVIEWED PUBLICATIONS. THROUGH THIS RENEWAL WE WILL CONTINUE TO SUBCONTRACT WITH OUR 5 HIGHLY QUALIFIED IICS TO ISOLATE AND DISTRIBUTE HUMAN ISLETS AND ANCILLARY TISSUE VIA OUR ADVANCED ELECTRONIC ISLET ALLOCATION SYSTEM (IAS). WE WILL CONTINUE TO MANAGE THE REVIEW PROCESS FOR ISLET RECEIPT, PILOT STUDIES, AND OPPORTUNITY POOL FUNDING. WE WILL FURTHER ENHANCE OUR IAS TO BROADCAST OFFERS ONLINE AND NOTIFY APPROVED WAITING RESEARCHERS OF ISLET AVAILABILITY, IN A FAIR, EQUITABLE AND TIME SENSITIVE MANNER. IIDP WILL CONTINUE TO MAINTAIN THE EXISTING COST RECOVERY SYSTEM THROUGH SUBSCRIPTION FEES COLLECTED FROM ISLET RESEARCHERS, WHICH HAS GARNERED A TOTAL OF $9,303,950 SINCE THE IMPLEMENTATION OF SUBSCRIPTION FEES TO OFFSET THE EXPENSES OF PANCREATIC PROCESSING FOR THE IICS. WE WILL CONTINUE TO CLOSELY MONITOR AND HELP TO IMPROVE THE QUALITY OF ISLETS DISTRIBUTED, THROUGH THE CONTINUATION OF THE HUMAN ISLET PHENOTYPING PROGRAM (HIPP) THAT CONDUCTS ASSAYS ON A SAMPLE FROM EACH ISLET ISOLATION. IIDP HAS JUST ADDED A HUMAN ISLET GENOTYPING INITIATIVE (HIGI) TO GENOTYPE EACH ISOLATION AS WELL. PHENOTYPING AND GENOTYPING DATA, AS WELL AS UNOS DATA, EXTENSIVE DONOR AND ISLET ISOLATION DATA, WILL BE MADE AVAILABLE TO APPROVED INVESTIGATORS THROUGH ONLINE ACCESS TO THE IIDP RESEARCH DATA REPOSITORY, WITH IIDP AND NIDDK APPROVAL OF APPLYING SCIENTISTS. INVESTIGATORS CAN EASILY SEARCH THE REQUIRED DATA, SELECT FILTER CRITERIA, SAVE THEIR SEARCHES, AND DOWNLOAD THE INTEGRATED IIDP DATA FOR EXPLORATORY ANALYSES. THROUGH OUR PROVEN STATE-OF-THE-ART ADMINISTRATIVE, BUSINESS, TECHNICAL, STATISTICAL, QUALITY ASSURANCE, AND INFORMATICS PROCESSES AND TOOLS, THE ACCESSIBILITY OF HUMAN ISLETS FOR INVESTIGATORS CONDUCTING ESSENTIAL DIABETES MELLITUS RESEARCH WILL BE SECURED. WE WILL CONTINUE TO PROVIDE AN INDISPENSABLE RESEARCH RESOURCE FOR THE DIABETES RESEARCH COMMUNITY BY ENSURING THAT THE IIDP REMAINS STABLE, TECHNOLOGICALLY ADVANCED, CONTINUALLY ENHANCED, AND FULLY RESPONSIVE TO THE ISLET NEEDS OF THE RESEARCH COMMUNITY, PROMOTING THE NEXT GENERATION OF SCIENTIFIC EXPERIMENTATION TOWARD THE PREVENTION AND TREATMENT OF DIABETES.

CALIFORNIA TEACHERS STUDY

ANTIBODY TARGETED RADIATION AND IMMUNOTHERAPY FOR THE TREATMENT OF SOLID TUMORS

THE OVERALL OBJECTIVE OF USAID EMPOWERED COMMUNITIES ACTIVITY IS TO ACHIEVE BETTER HEALTH AND NUTRITIONAL OUTCOMES THROUGH IMPROVED COMMUNITY OWNERSHIP OF HEALTH AND STRENGTHENED SOCIAL ACCOUNTABILITY SYSTEMS AND PLATFORMS. THE ACTIVITY WILL BE PRIMARILY FUNDED WITH FAMILY PLANNING, AND MATERNAL AND CHILD HEALTH FUNDING. THEREFORE, ALL EXPECTED RESULTS AND PROPOSED INTERVENTIONS SHOULD CONTRIBUTE TO THE BETTERMENT OF THE LIVES OF WOMEN, CHILDREN, YOUTH AND MEN ULTIMATELY, IMPROVED REPRODUCTIVE, MATERNAL, NEWBORN, CHILD AND ADOLESCENT HEALTH AND NUTRITION (RMNCAH-N) OUTCOMES.

HEALTH CENTER CLUSTER

HEAD START

PATHWAYS TO HOPE PROJECT

HOPE ENTERPRISE CORPORATION'S CHARTER SCHOOL FACILITIES FUND

HEALTH CENTER CLUSTER

IMPROVE EXISTING AIRPORT E

HUMAN ISLET RESEARCH ENHANCEMENT CENTER FOR THE HUMAN ISLET RESEARCH NETWORK

ONCOLOGY RESEARCH CAREER DEVELOPMENT PROGRAM

RESIDENTIAL (SHELTER AND/OR TRANSITIONAL FOSTER CARE) SERVICES FOR UNACCOMPANIED CHILDREN-LICENSED AND TEXAS-EXEMPT AND FLORIDA-DELICENSED ONLY

THE PROPOSED ACTIVITY IS A FIVE-YEAR TRANSITION AWARD TO SIGNIFICANTLY REDUCE PREVENTABLE DEATHS OF MOTHERS, NEWBORNS, AND CHILDREN. THE IHP ACTIVITY WILL ENGAGE WITH GHANA’S HEALTH SYSTEM STAKEHOLDERS ACROSS PUBLIC, PRIVATE, AND FAITH-BASED SECTORS TO FOSTER IMPROVEMENTS IN HEALTH SERVICE ACCESS, DEMAND, QUALITY AND ENABLING ENVIRONMENT.

PALLIATIVE CARE FOR QUALITY OF LIFE AND SYMPTOM CONCERNS IN LUNG CANCER

COMBATING SUBCLONAL EVOLUTION OF RESISTANT CANCER PHENOTYPES

HEALTH CENTER CLUSTER

IMPROVE EXISTING AIRPORT

NEW BIOSPECIMENS TO ENHANCE RESEARCH IN THE CALIFORNIA TEACHERS STUDY COHORT

HEALTH CENTER CLUSTER

INCREMENTAL FUNDING. PROGRAM SUPPORT FOR "SUSTAINABLE STRENGTHENING OF FAMILIES OF ORPHANS AND OTHER CHILDREN."

HEMATOPOIETIC CELL TRANSPLANTATION FOR HEMATOLOGIC MALIGNANCIES

PURPOSE: CONSTRUCT TERMINAL. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT CONSTRUCTS A NEW 355,000 SQUARE FOOT TERMINAL TO ACCOMMODATE THE MOVEMENT OF PASSENGERS AND BAGGAGE. THIS GRANT FUNDS PHASE 4, WHICH CONSISTS OF CONSTRUCTION OF THE TERMINAL BUILDING ARCHITECTURAL GLASS AND ALUMINUM. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH BURBANK, CALIFORNIA.

PREVENTING NEW HIV INFECTIONS AND REDUCING VULNERABILITIES AMONG OVC AND AGYW THROUGH OVC AND DREAMS PROGRAMMING

TB LOCAL ORGANIZATION NETWORK

AMERICAN RESCUE PLAN ACT FUNDING FOR HEALTH CENTERS

COMMUNITY-BASED WORKFORCE TO BUILD COVID-19 VACCINE CONFIDENCE

IMPROVE EXISTING AIRPORT

NEW AWARD UNDER NEW PARTNERS INITIATIVE

RESIDENTIAL (SHELTER AND/OR TRANSITIONAL FOSTER CARE) SERVICES FOR UNACCOMPANIED CHILDREN- PRELICENSED - A GREATER HOPE IS A FEDERALLY FUNDED RESIDENTIAL TFC PROGRAM WITHIN THE OFFICE OF REFUGEE RESETTLEMENT (ORR) THAT PROVIDES TEMPORARY CARE AND SERVICES FOR UNACCOMPANIED ALIEN CHILDREN ARRIVING IN THE UNITED STATES WITHOUT PARENTS OR LEGAL GUARDIANS. THE PROGRAM ENSURES CHILDREN RECEIVE ESSENTIAL SERVICES INCLUDING HOUSING, MEDICAL CARE, EDUCATION, AND MENTAL HEALTH SUPPORT WHILE IDENTIFYING AND VETTING SUITABLE SPONSORS THROUGH COMPREHENSIVE BACKGROUND CHECKS. THE PRIMARY OBJECTIVE IS TO SAFELY REUNITE CHILDREN WITH VETTED SPONSORS IN THE LEAST RESTRICTIVE ENVIRONMENT WHILE MAINTAINING ONGOING CASE MANAGEMENT AND SUPPORT SERVICES.

PRECISION APPROACHES TO REFINING TP53-ASSOCIATED CANCER RISK

HEAD START PROGRAM

PURPOSE: CONSTRUCT TERMINAL. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT CONSTRUCTS A 355,000 SQUARE FOOT TERMINAL BUILDING TO MEET DESIGN POLICY STANDARDS. THIS GRANT FUNDS THE THIRD PHASE, WHICH CONSISTS OF THE CONSTRUCTION OF THE TERMINAL BUILDING FOUNDATIONAL CONCRETE, FOUNDATIONAL STEEL, AND WATERPROOFING. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH BURBANK, CALIFORNIA.

PURPOSE: CONSTRUCT APRON. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT CONSTRUCTS A NEW 105,816 SQUARE YARD TERMINAL APRON TO BRING THE AIRPORT INTO CONFORMITY WITH CURRENT STANDARDS. THIS GRANT FUNDS PHASE 1, WHICH CONSISTS OF CONSTRUCTION OF 31,745 SQUARE YARDS. . INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH BURBANK, CALIFORNIA.

CREDIT ENHANCEMENT FOR CHARTER SCHOOL FACILITIES FOR BUILDING HOPE'S AMERICA'S CHARTER PROGRAM

HOPE'S CHARTER SCHOOL FACILITIES FUND: STRENGTHENING THE CHARTER SCHOOL SECTORS IN ALABAMA, ARKANSAS, LOUISIANA, MISSISSIPPI, AND TENNESSEE

CREDIT ENHANCEMENT FOR CHARTER SCHOOL FACILITIES PROGRAM

NONCODING RNA BIOMARKERS FOR NONINVASIVE AND EARLY DETECTION OF PANCREATIC CANCER

PURPOSE: CONSTRUCT APRON. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT CONSTRUCTS A NEW 105,816 SQUARE YARD TERMINAL APRON TO BRING THE AIRPORT INTO CONFORMITY WITH CURRENT STANDARDS. THIS GRANT FUNDS THE FINAL PHASE, WHICH CONSISTS OF CONSTRUCTION OF 74,071 SQUARE YARDS. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH BURBANK, CALIFORNIA.

HEAD START

PURCHASE LAND AND PROVIDE TECHNICAL ASSISTANCE TO FARMERS TO INCREASE CAPITAL AND MARKET ACCESS.

INDIAN HSG BLOCK GR

RNA DIRECTED SILENCING AND EXCISION OF HIV-1 AND CCR5

HUMAN NATURAL KILLER CELLS: ADVANCING BIOLOGY AND CLINICAL APPLICATIONS

HEAD START

IMPROVE EXISTING AIRPORT

THIS PROJECT WILL SCALE-UP AND REFINE THE CURRENT HIV/AIDS PREVENTION ACTIVITIES

INTEGRATION OF PALLIATIVE CARE FOR CANCER PATIENTS ON PHASE I TRIALS

VA IS PROVIDING PER DIEM FUNDING TO ASSIST WITH THE OPERATIONAL COSTS ASSOCIATED WITH TRANSITIONAL HOUSING BEDS FOR HOMELESS VETERANS.

LONG-TERM CAPACITY FOR HIV PREVENTION EDUCATION TO YOUTH

RYAN WHITE PART C OUTPATIENT EIS PROGRAM

TRANSCRIPTIONAL REGULATION BY ANGIOTENSIN II IN VASCULAR SMOOTH MUSCLE CELLS

IMPROVE EXISTING AIRPORT

IMPROVE THE WELLBIENG OF ORPHANS AND VULNERABLE CHILDREN AND TUBECLULOSIS PREVENTION.

HOMELESS PREVENTION

PURPOSE: RECONSTRUCT RUNWAY LIGHTING; REHABILITATE RUNWAY. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT RECONSTRUCTS EXISTING RUNWAY 1/19 LIGHTING THAT HAS REACHED THE END OF ITS USEFUL LIFE. THIS PROJECT REHABILITATES 6,600 FEET OF EXISTING PAVED RUNWAY 01/19 TO MAINTAIN THE STRUCTURAL INTEGRITY AND MINIMIZE FOREIGN OBJECT DEBRIS TO EXTEND ITS USEFUL LIFE. THIS GRANT FUNDS THE FINAL PHASE, WHICH CONSISTS OF CONSTRUCTION. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH FAIRHOPE, ALABAMA.

REFINE THE CURRENT HIV/AIDS PREVENTION ACTIVITIES BY HOPE WORLDWIDE KENYA (HWWK)

AFFORDABLE CARE ACT - CAPITAL DEVELOPMENT GRANTS

INTESTINAL STEM CELL CONSORTIUM COORDINATING CENTER

PURPOSE: TO PROVIDE GRANTS TO COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS (CDFIS) FOR THE FOLLOWING PURPOSES 1) TO EXPAND LENDING, GRANT MAKING AND INVESTMENT ACTIVITIES IN LOW OR MODERATE INCOME COMMUNITIES AND TO BORROWERS THAT HAVE HISTORICALLY EXPERIENCED SIGNIFICANT UNMET CAPITAL AND FINANCIAL SERVICES NEEDS AND WERE DISPROPORTIONATELY IMPACTED BY THE COVID 19 PANDEMIC; AND 2) TO ENABLE CDFIS TO BUILD ORGANIZATIONAL CAPACITY AND ACQUIRE TECHNOLOGY, STAFF, AND OTHER TOOLS NECESSARY TO ACCOMPLISH THE ACTIVITIES UNDER A CDFI ERP AWARD. PLANNED ACTIVITIES: ELIGIBLE ACTIVITIES INCLUDE FINANCIAL PRODUCTS, FINANCIAL SERVICES, DEVELOPMENT SERVICES, GRANTS, LOAN LOSS RESERVES AND CAPITAL RESERVES THAT MAY BE USED TO MITIGATE THE IMPACT OF THE COVID 19 PANDEMIC ON UNEMPLOYMENT, CHILDCARE, HEALTHCARE, MENTAL HEALTHCARE, AFFORDABLE HOUSING, AFFORDABLE HOUSING FINANCE, SMALL BUSINESS, SMALL FARMS, BROADBAND INTERNET, AND FOOD SUFFICIENCY. IN ADDITION, TO SUPPORT CDFIS IN BUILDING THEIR CAPACITY TO RESPOND TO THE ECONOMIC IMPACT OF COVID 19, CDFI ERP AWARDS MAY BE USED FOR COMPENSATION PERSONAL SERVICES; COMPENSATION FRINGE BENEFITS; PROFESSIONAL SERVICE COSTS; TRAVEL COSTS; TRAINING AND EDUCATION COSTS; EQUIPMENT; SUPPLIES. END GOALS: EXPANDED FINANCING FOR LOW TO MODERATE INCOME COMMUNITIES AND INDIVIDUALS THAT HAVE HISTORICALLY EXPERIENCED SIGNIFICANT UNMET CAPITAL AND FINANCIAL SERVICES NEEDS AND WERE DISPROPORTIONATELY IMPACTED BY THE COVID 19 PANDEMIC INCLUDING SPECIFIC DESIGNATED COVID IMPACTED CDFI ERP ELIGIBLE GEOGRAPHIES AS AREAS THAT MAY BENEFIT FROM CDFI ERP ASSISTANCE. BENEFICIARIES: CERTIFIED CDFIS WHICH MAY BE FOR PROFIT ORGANIZATION, PRIVATE NONPROFIT INSTITUTION/ORGANIZATION, AND OTHER PRIVATE INSTITUTION/ORGANIZATION, AS DEFINED IN 12 C.F.R. 1805, AND LOW AND MODERATE INCOME INDIVIDUALS AND FAMILIES. SUBRECIPIENTS: THERE ARE NO SUBRECIPIENTS FOR THIS PROGRAM. BROADBAND: SPECIFIC ACTIVITIES RELATING TO BROADBAND USAGE ARE NOT KNOWN AT THE TIME OF AWARD. REASON/PURPOSE OF MODIFICATION: NOT APPLICABLE.

AMERICAN RESCUE PLAN ACT FUNDING FOR HEALTH CENTERS

DIFFERENTIAL MECHANISMS FOR RORGAMMAT-REGULATED THYMOCYTE DEVELOPMENT AND TH17 DI

TRANSFORMING GROWTH FACTOR BETA1, MICRORNAS AND DIABETIC NEPHROPATHY

12 MONTH AWARD FOR $6M TO PROJECT HOPE FOR A FOR PROTECTION ACTIVITIES IN HAITI (GBV, RCCE, WASH/HEALTH COMMODITIES)

HOPE COLLEGE - INSTITUTIONAL PORTION OF THE HIGHER EDUCATION EMERGENCY RELIEF FUND

THE NATIVE VILLAGE OF POINT HOPE TRANSPORTATION INFRASTRUCTURE AND TRANSIT IMPROVEMENT PROJECT

INFLAMMATORY GENE REGULATION IN DIABETIC CONDITIONS

FUNCTIONAL ANALYSIS OF FEN-1 NUCLEASE IN GENOME STABILITY AND CANCERS

HEALTH CENTER PROGRAM

REGULATION OF IONIZING RADIATION INDUCED DNA DAMAGE RESPONSE

ROLE OF NUCLEASES IN RNA PRIMER REMOVAL AND MUTAGENESIS

ROLE OF AUTOREACTIVITY IN PATHOGENESIS OF CHRONIC GVHD

DIGITAL HEALTH INTERVENTION FOR SELF-MANAGEMENT AND TELEMONITORING IN CHIMERIC ANTIGEN RECEPTOR-T CELL THERAPY

COMBINATORIAL USE OF ANTI-HIV RNA-BASED THERAPEUTICS

A HUMAN IPSC-BASED CELL THERAPY FOR CANAVAN DISEASE - PROJECT SUMMARY CANAVAN DISEASE (CD) IS A RARE, AUTOSOMAL RECESSIVE NEURODEVELOPMENTAL DISORDER THAT AFFECTS CHILDREN FROM INFANCY. MOST CHILDREN WITH INFANTILE-ONSET CD, THE MOST PREVALENT FORM OF THE DISEASE, WILL DIE WITHIN THE FIRST DECADE OF LIFE. THERE IS NEITHER A CURE NOR A STANDARD TREATMENT FOR THIS DISEASE. CD IS CAUSED BY GENETIC MUTATIONS IN THE ASPARTOACYLASE (ASPA) GENE, WHICH ENCODES A METABOLIC ENZYME SYNTHESIZED BY OLIGODENDROCYTES IN THE BRAIN. ASPA BREAKS DOWN N-ACETYL-ASPARTATE (NAA), AN AMINO ACID DERIVATIVE IN THE BRAIN. THE CYCLE OF PRODUCTION AND BREAKDOWN OF NAA APPEARS TO BE CRITICAL FOR MAINTAINING THE WHITE MATTER OF THE BRAIN, WHICH CONSISTS OF NERVE FIBERS COVERED BY MYELIN. INDICATIONS OF CD INCLUDE LACK OF ASPA ACTIVITY, ACCUMULATION OF NAA, MYELINATION DEFECT, AND SPONGY DEGENERATION (VACUOLATION) IN THE BRAIN. THE CLINICAL SYMPTOMS INCLUDE IMPAIRED MOTOR FUNCTION AND MENTAL RETARDATION. THERE IS CURRENTLY NO APPROVED THERAPY FOR THIS CONDITION. THEREFORE, THERE IS A CLEAR, UNMET MEDICAL NEED FOR AN EFFECTIVE THERAPY FOR CD. THE DEVELOPMENT OF HUMAN INDUCED PLURIPOTENT STEM CELL (HIPSC) TECHNOLOGY HAS OPENED EXCITING AVENUES FOR CELL THERAPY. IN OUR PRELIMINARY STUDIES, WE HAVE USED HIPSC TECHNOLOGY TO GENERATE CD PATIENT IPSCS AND DIFFERENTIATED THESE IPSCS INTO NEURAL PROGENITOR CELLS (CD INPCS). WE THEN INTRODUCED A FUNCTIONAL ASPA GENE INTO CD INPCS THROUGH LENTIVIRAL TRANSDUCTION TO GENERATE GENETICALLY ENGINEERED FUNCTIONAL ASPA-CONTAINING INPCS, TERMED ASPA INPCS. IN ORDER TO MOVE THE ASPA INPC CELL PRODUCT TO THE CLINIC, WE DEVELOPED CURRENT GOOD MANUFACTURING PRACTICE (CGMP)-COMPATIBLE PROCESS TO MANUFACTURE THE ASPA INPCS. THE RESULTANT ASPA INPCS GENERATED FROM THREE DIFFERENT CD PATIENTS WERE TESTED IN A CD MOUSE MODEL FOR EFFICACY AND SAFETY. AFTER BEING TRANSPLANTED INTO BRAINS OF CD MICE, THE ASPA INPCS PROVIDED SUSTAINED ASPA ACTIVITY, LED TO SIGNIFICANTLY LOWER NAA LEVEL, CONSIDERABLE RESCUE OF SPONGY DEGENERATION AND MYELINATION DEFECT IN THE BRAIN, AND SUBSTANTIALLY IMPROVED MOTOR FUNCTION IN THE TRANSPLANTED CD MICE. IMPORTANTLY, NO TUMORIGENESIS OR OTHER ADVERSE EFFECT WAS OBSERVED IN THE TRANSPLANTED MICE. THESE ROBUST PRECLINICAL DATA PROVIDE STRONG RATIONALE FOR THE PROPOSED STUDY. THE OBJECT OF THE PROPOSED RESEARCH IS TO ESTABLISH A HIPSC-BASED CELL THERAPY FOR CD. THE CELL PRODUCTS HAVE PROVEN IN PRECLINICAL STUDIES TO BE LONG LASTING AND EFFICACIOUS WITH A FAVORABLE SAFETY PROFILE. WE PROPOSE THE FOLLOWING SPECIFIC AIMS: AIM 1: TO CONDUCT IND-ENABLING QUALIFICATION RUNS AND PERFORM FINAL MANUFACTURING OF THE ASPA INPC CELL PRODUCTS. AIM 2: TO PERFORM DEFINITIVE PRECLINICAL EFFICACY AND SAFETY/TUMORIGENICITY STUDIES OF THE ASPA INPC CELL PRODUCTS. AIM 3: TO OBTAIN IND APPROVAL. AIM 4: TO CONDUCT A PHASE I CLINICAL TRIAL TO ESTABLISH THE SAFETY AND FEASIBILITY OF ADMINISTERING THE ASPA INPC CELL PRODUCTS TO CD PATIENTS. THIS STUDY COULD LEAD TO THE DEVELOPMENT OF A NOVEL CELL THERAPY FOR CD AND DEMONSTRATE THE FEASIBILITY OF USING HIPSC-BASED CELL PRODUCTS FOR THE TREATMENT OF SIMILAR DISEASES.

AMERICAN RESCUE PLAN ACT FUNDING FOR HEALTH CENTERS

CARES FUNDING FOR COVID19. THE SSVF PROGRAM'S PURPOSE IS TO PROVIDE SUPPORTIVE SERVICES GRANTS TO PRIVATE NON-PROFIT ORGANIZATIONS AND CONSUMER COOPERATIVES, WHO WILL COORDINATE OR PROVIDE SUPPORTIVE SERVICES TO VERY LOW-INCOME VETERAN FAMILIES WHO ARE RESIDING IN PERMANENT HOUSING, ARE HOMELESS AND SCHEDULED TO BECOME RESIDENTS OF PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD; OR AFTER EXITING PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD, ARE SEEKING OTHER HOUSING THAT IS RESPONSIVE TO SUCH VERY LOW-INCOME VETERAN FAMILY'S NEEDS AND PREFERENCES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES.

NCN ANNOUNCEMENT - REGION 02 - SD - 2015 - SEPTEMBER

REGULATION OF GLUCOSE HOMEOSTASIS BY MUNC18 PROTEINS

HUMAN ISLET RESEARCH NETWORK (HIRN) COORDINATING CENTER

THE ROLE OF INTESTINAL MICROBIOTA IN GRAFT-VERSUS-HOST DISEASE

SUMO MODIFICATION AND DNA DAMAGE RESPONSE IN CANCER THERAPY

MUCUS-DEGRADING INTESTINAL BACTERIA AND TOXICITIES OF HEMATOPOIETIC CELL TRANSPLANTATION - OVERALL PROGRAM SUMMARY: MUCUS-DEGRADING INTESTINAL BACTERIA AND TOXICITIES OF HEMATOPOIETIC CELL TRANSPLANTATION THE MICROBIAL COMMUNITY (MICROBIOTA) IN THE HUMAN GUT PLAYS A CENTRAL ROLE IN DIGESTION OF DIETARY FIBER, PROVIDING NUTRIENTS TO THE GUT MICROBIOTA AS WELL AS TO THE HOST THROUGH FERMENTATION PRODUCTS LIKE SHORT-CHAIN FATTY ACIDS. A MINORITY OF GUT BACTERIA CAN ALSO UTILIZE NUTRIENTS DERIVED FROM MUCUS, A COMPLEX MIXTURE OF SECRETED, MUCIN GLYCOPROTEINS THAT FORM A LAYER OVER THE EPITHELIUM TO PROTECT IT FROM MICROBIAL ENCROACHMENT. THE MOST ABUNDANT MUCIN UTILIZERS ARE MEMBERS OF THE GENERA AKKERMANSIA AND BACTEROIDES. ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION (ALLO HCT) IS AN IMPORTANT TREATMENT MODALITY PERFORMED FOR A VARIETY OF BENIGN AND MALIGNANT HEMATOLOGICAL CONDITIONS. PATIENTS RECEIVE SYSTEMIC CYTOTOXIC CONDITIONING, FOLLOWED BY INFUSION OF ALLOGENEIC HEMATOPOIETIC CELLS. IN TWO RECENT MANUSCRIPTS CO-AUTHORED BY THE PROGRAM PROJECT GRANT (PPG) PROJECT AND CORE LEADERS, MUCIN-UTILIZING INTESTINAL BACTERIA WERE FOUND TO CONTRIBUTE TO INTESTINAL GRAFT-VERSUS-HOST DISEASE (GVHD) THAT IS AGGRAVATED BY MEROPENEM ANTIBIOTIC TREATMENT, AND NEUTROPENIC FEVER (NF). THIS IS A REVISED PPG PROPOSAL WITH 3 INTEGRATED PROJECTS ADDRESSING HOW MUCIN-UTILIZING INTESTINAL BACTERIA CONTRIBUTE TO INTESTINAL GVHD. RECENT PRELIMINARY DATA FROM EXPERIMENTS PERFORMED IN MICE IDENTIFIED THAT AKKERMANSIA AND BACTEROIDES COMBINE TO COMPROMISE THE COLONIC MUCUS LAYER, PRODUCE HYPOTHERMIA IN MODELS OF HCT CONDITIONING, AND AGGRAVATE INTESTINAL GVHD. THE PROJECTS OF THIS PPG WILL EXTEND THESE FINDINGS, IMPROVING OUR UNDERSTANDING OF HOW DIET AND METABOLISM MODULATE EXPRESSION OF MUCIN-DEGRADING ENZYMES IN AKKERMANSIA AND BACTEROIDES. PROJECT 1 BUILDS UPON EXPERTISE IN CLINICAL ALLO HCT MICROBIOME PROFILING AND PRECLINICAL MODELING TO DEVELOP TRANSLATIONAL APPROACHES. PROJECT 2 INCORPORATES AN UNDERSTANDING OF THE NATURAL LANDSCAPE OF AKKERMANSIA GENETIC HETEROGENEITY, COUPLED WITH AN EXTENSIVE LIBRARY OF FUNCTIONAL AKKERMANSIA MUTANTS TO DEEPLY CHARACTERIZE THE ROLE OF AKKERMANSIA IN INTESTINAL GVHD. FINALLY, PROJECT 3 OFFERS A COMPREHENSIVE ANALYSIS OF THE EFFECTS OF SPECIFIC DIETARY GLYCANS ON MUCIN-DEGRADING BACTEROIDES AND GENETIC UNDERPINNINGS REGULATING EXPRESSION OF MUCIN-DEGRADING ENZYMES. SUPPORTING THESE ARE 2 UNIQUE CORES. CORE A WILL PROVIDE ADMINISTRATIVE SERVICES, MICROBIOME- SPECIALIZED BIOSTATISTICAL SUPPORT, CLINICAL SPECIMEN AND DATA COLLECTION FROM PATIENTS UNDERGOING ALLO HCT AT TWO CENTERS, AND BIONUTRITIONAL SUPPORT FOR COLLECTION OF DIETARY DATA SUPPLEMENTED BY METAGENOMIC SEQUENCING OF FECAL CHLOROPLAST DNA. CORE B WILL PERFORM RANDOM AND TARGETED BACTERIAL MUTAGENESIS TO SUPPORT HIGH THROUGHPUT MUTANT SCREENS AS WELL AS TESTING SPECIFIC HYPOTHESES, GENERATE FLUORESCENTLY LABELLED GLYCANS TO VISUALIZE GLYCAN UPTAKE AND DEGRADATION AT THE SINGLE CELL LEVEL, AND BUILD A DATABASE OF MUCIN-DEGRADING BACTERIAL ENZYMES THAT WILL SERVE AS A RESOURCE FOR THE INTESTINAL MICROBIOME COMMUNITY.

PURPOSE: THE PURPOSE OF THE PUBLIC HOUSING HOUSING-RELATED HAZARDS AND LEAD-BASED PAINT CAPITAL FUND PROGRAM IS TO EVALUATE AND REDUCE RESIDENTIAL HEALTH HAZARDS IN PUBLIC HOUSING, INCLUDING LEAD-BASED PAINT, CARBON MONOXIDE, MOLD, RADON, FIRE SAFETY, AND ASBESTOS. APPROXIMATELY 2,770 PUBLIC HOUSING AGENCIES (PHAS) SERVING NEARLY ONE MILLION UNITS, IN ALL 50 STATES AND TERRITORIES ARE ELIGIBLE TO APPLY. GRANTS ARE COMPETITIVELY AWARDED BASED ON SCORING CRITERIA LISTED IN THE CORRESPONDING PUBLIC NOFO. ADDITIONAL INFORMATION ON THE PUBLIC HOUSING CAPITAL FUND IS LOCATED ON THE OFFICE OF CAPITAL IMPROVEMENTS WEBSITE: HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/PUBLIC_INDIAN_HOUSING/PROGRAMS/PH/CAPFUND ADDITIONAL INFORMATION ON PUBLIC HOUSING FUNDING CAN BE FOUND BY ACCESSING HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/PUBLIC_INDIAN_HOUSING/PROGRAMS/PH AND REVIEWING THE PUBLIC HOUSING DASHBOARD LINKED UNDER THE “DATA DASHBOARD AND ANALYTICS”.; ACTIVITIES TO BE PERFORMED: HOUSING-RELATED HAZARD FUNDS SHALL BE MADE AVAILABLE FOR COMPETITIVE GRANTS TO PHAS TO EVALUATE AND REDUCE HOUSING-RELATED HAZARDS INCLUDING CARBON MONOXIDE, MOLD, RADON, FIRE SAFETY, AND ASBESTOS. LEAD-BASED PAINT FUNDS SHALL BE MADE AVAILABLE FOR COMPETITIVE GRANTS TO PUBLIC HOUSING AGENCIES FOR EVALUATING AND REDUCING LEAD-BASED PAINT HAZARDS SPECIFICALLY BY CARRYING OUT THE ACTIVITIES OF LEAD-BASED RISK ASSESSMENTS, INSPECTIONS, ABATEMENT, INTERIM CONTROLS, CLEARANCE EXAMINATIONS, AND RELOCATION IN PUBLIC HOUSING. OTHER WORK AT THE PROPERTY, INCLUDING WORK TO PREPARE FOR LEAD HAZARD CONTROL (E.G., REPAIRS TO THE SUBSTRATE, FIXING LEAKS OR OTHER RENOVATIONS) SHALL BE FUNDED BY OTHER SOURCES. FUNDS MAY ONLY BE USED IN PUBLIC HOUSING, AS DEFINED BY SECTION 3 OF THE UNITED STATES HOUSING ACT OF 1937 (1937 ACT) AND PHAS PARTICIPATING IN THE CAPITAL FUND PROGRAM UNDER SECTION 9 OF THE 1937 ACT AND 24 CFR PART 905. FUNDS AWARDED FOR LEAD-BASED PAINT GRANT ACTIVITIES MAY NOT BE EXPENDED AT THE INVENTORY MANAGEMENT SYSTEM/PIH INFORMATION CENTER (IMS/PIC) DEVELOPMENT(S)/ASSET MANAGEMENT PROJECT (AMP) THAT DO NOT MEET THE DEFINITION OF TARGET HOUSING AS DEFINED UNDER THE RESIDENTIAL LEAD-BASED PAINT HAZARD REDUCTION ACT OF 1992. BUILDINGS THAT MEET THE DEFINITION OF TARGET HOUSING BUT ARE MISSING CONSTRUCTION DATES IN THE IMS/PIC SYSTEM MUST BE UPDATED IN THE PIC SYSTEM PRIOR TO THE APPLICATION CLOSE DATE TO REFLECT THE ACTUAL CONSTRUCTION DATE.; EXPECTED OUTCOMES: THE EXPECTED OUTCOMES FOR PUBLIC HOUSING HOUSING-RELATED HAZARDS AND LEAD-BASED PAINT CAPITAL FUNDS ARE THE COMPLETION OF THE SPECIFIC APPROVED PROJECT TO EVALUATE AND REDUCE HOUSING-RELATED AND LEAD-BASED PAINT HAZARDS. THE MEASURABLE OUTCOME OF THIS GRANT IS THAT HUD WILL BE ABLE TO TRACK THE AMOUNT OF DOLLARS SPENT ON HOUSING-RELATED HAZARDS AND LEAD-BASED PAINT HAZARDS ELIGIBLE ACTIVITIES BASED ON THE APPROVED GRANT APPLICATION. ; INTENDED BENEFICIARIES: THE INTENDED BENEFICIARIES FOR PUBLIC HOUSING HOUSING-RELATED HAZARDS AND LEAD-BASED PAINT CAPITAL FUNDS ARE LOW-INCOME PUBLIC HOUSING RESIDENTS.; SUBRECIPIENT ACTIVITIES: THE RECIPIENT DOES NOT INTEND TO SUBAWARD FUNDS.

CAPITAL DEVELOPMENT

THEHOPE CENTER OF ORANGE COUNTY DBA THE NORTH ORANGE COUNTY PUBLIC SAFETY COLLABORATIVEPROPOSES TO IMPLEMENT THENORTH ORANGE COUNTY PUBLIC SAFETY COLLABORATIVE (COLLABORATIVE).THE PURPOSE IS TOPROVIDE A STRUCTURED, COLLABORATIVE AND HIGHLY LEVERAGED APPROACH TO HOMELESS STREET OUTREACH AND ENGAGEMENTIN THECOUNTY OF ORANGE, CA NORTH SERVICE PLANNING AREA WHICH CONSISTS OF ELEVEN CITIES.PROJECT ACTIVITIES INCLUDECENTRALIZING RESOURCES, INTEGRATING DATA AND COORDINATING RESPONSES TO HOMELESS CALLS. EXPECTED OUTCOMES INCLUDE:CENTRALIZE RESOURCES, COORDINATE THE RIGHT RESOURCES BY WORKING WITH COMMUNITY-BASED ORGANIZATIONS, BEHAVIOR HEALTH SPECIALISTS, SOCIAL WORKERS AND CITY/COUNTY AND HOPE CENTER CASE MANAGERS ACROSS CITY BOUNDARIES.HOMELESS CLIENTS, INCLUDING MALE, FEMALES, FAMILIES AND VETERANS IN OUR 11 CITIESARE THE INTENDED BENEFICIARIES OF THE PROJECT. PROJECT ACTIVITIES ALSO INCLUDEDISPATCH TO HOMELESS CALLS BY THE RIGHT RESOURCES, REDUCING POLICE RESPONSE TO HOMELESS CALLS, PROVIDING STREET OUTREACH PROACTIVELY AND OFFERING SERVICES TO REDUCE HOMELESSNESS.THE COLLABORATIVE'S MOTTO IS THE RIGHT PEOPLE, RIGHT RESOURCES, RIGHT NOW.

FINANCIAL ASSISTANCE AWARD

CONFORMAL TOTAL BODY AND MARROW IRRADIATION FOR LEUKEMIA

HIGHER EDUCATION EMERGENCY RELIEF FUND - HOPE COLLEGE

PURPOSE: TO PROVIDE GRANTS TO COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS (CDFIS) FOR THE FOLLOWING PURPOSES 1) TO EXPAND LENDING, GRANT MAKING AND INVESTMENT ACTIVITIES IN LOW OR MODERATE INCOME COMMUNITIES AND TO BORROWERS THAT HAVE HISTORICALLY EXPERIENCED SIGNIFICANT UNMET CAPITAL AND FINANCIAL SERVICES NEEDS AND WERE DISPROPORTIONATELY IMPACTED BY THE COVID 19 PANDEMIC; AND 2) TO ENABLE CDFIS TO BUILD ORGANIZATIONAL CAPACITY AND ACQUIRE TECHNOLOGY, STAFF, AND OTHER TOOLS NECESSARY TO ACCOMPLISH THE ACTIVITIES UNDER A CDFI ERP AWARD. PLANNED ACTIVITIES: ELIGIBLE ACTIVITIES INCLUDE FINANCIAL PRODUCTS, FINANCIAL SERVICES, DEVELOPMENT SERVICES, GRANTS, LOAN LOSS RESERVES AND CAPITAL RESERVES THAT MAY BE USED TO MITIGATE THE IMPACT OF THE COVID 19 PANDEMIC ON UNEMPLOYMENT, CHILDCARE, HEALTHCARE, MENTAL HEALTHCARE, AFFORDABLE HOUSING, AFFORDABLE HOUSING FINANCE, SMALL BUSINESS, SMALL FARMS, BROADBAND INTERNET, AND FOOD SUFFICIENCY. IN ADDITION, TO SUPPORT CDFIS IN BUILDING THEIR CAPACITY TO RESPOND TO THE ECONOMIC IMPACT OF COVID 19, CDFI ERP AWARDS MAY BE USED FOR COMPENSATION PERSONAL SERVICES; COMPENSATION FRINGE BENEFITS; PROFESSIONAL SERVICE COSTS; TRAVEL COSTS; TRAINING AND EDUCATION COSTS; EQUIPMENT; SUPPLIES. END GOALS: EXPANDED FINANCING FOR LOW TO MODERATE INCOME COMMUNITIES AND INDIVIDUALS THAT HAVE HISTORICALLY EXPERIENCED SIGNIFICANT UNMET CAPITAL AND FINANCIAL SERVICES NEEDS AND WERE DISPROPORTIONATELY IMPACTED BY THE COVID 19 PANDEMIC INCLUDING SPECIFIC DESIGNATED COVID IMPACTED CDFI ERP ELIGIBLE GEOGRAPHIES AS AREAS THAT MAY BENEFIT FROM CDFI ERP ASSISTANCE. BENEFICIARIES: CERTIFIED CDFIS WHICH MAY BE FOR PROFIT ORGANIZATION, PRIVATE NONPROFIT INSTITUTION/ORGANIZATION, AND OTHER PRIVATE INSTITUTION/ORGANIZATION, AS DEFINED IN 12 C.F.R. 1805, AND LOW AND MODERATE INCOME INDIVIDUALS AND FAMILIES. SUBRECIPIENTS: THERE ARE NO SUBRECIPIENTS FOR THIS PROGRAM. BROADBAND: SPECIFIC ACTIVITIES RELATING TO BROADBAND USAGE ARE NOT KNOWN AT THE TIME OF AWARD. REASON/PURPOSE OF MODIFICATION: NOT APPLICABLE.

TUBERCULOSIS CONTROL PROGRAM FOR CAR

MENOPAUSAL TRANSITION - A WINDOW OF SUSCEPTIBILITY FOR THE PROMOTION OF BREAST CANCER BY ENVIRONMENTAL EXPOSURES

TARGETING MICRORNAS TO ERADICATE LEUKEMIA STEM CELLS

UNMASKING THE ROLES OF VIRAL GLYCOPROTEINS IN ORAL TRANSMISSION OF KSHV - PROJECT SUMMARY MORE THAN 44,000 NEW CASES OF KAPOSI SARCOMA (KS) ARE REPORTED GLOBALLY EACH YEAR, 84% OF WHICH OCCUR IN AFRICA. THIS AND OTHER KAPOSI SARCOMA-ASSOCIATED HERPESVIRUS (KSHV)-INDUCED MALIGNANCIES PREDOMINATE IN PEOPLE WITH ACQUIRED OR IATROGENIC IMMUNODEFICIENCIES. ALTHOUGH KSHV CAN BE DETECTED IN OTHER HUMAN BODY FLUIDS, ITS FREQUENT DETECTION IN SALIVA IN GROUPS BOTH WITH AND WITHOUT RISK OF SEXUALLY TRANSMITTED INFECTIONS (E.G., CHILDREN) SUGGESTS THAT THE ORAL CAVITY IS THE SITE OF PRIMARY ACQUISITION. HOWEVER, THE MECHANISM OF KSHV ORAL TRANSMISSION IN VIVO, PARTICULARLY THE CRITICAL VIRAL ENVELOPE GLYCOPROTEINS (GPS) REQUIRED FOR VIRAL ENTRY, REMAINS UNRESOLVED. SEVERAL KSHV–HOST INTERACTIONS HAVE BEEN IDENTIFIED, BUT ALL PRIOR EXPERIMENTS WERE PERFORMED IN VITRO AND HAVE NOT BEEN VALIDATED IN VIVO DUE TO PRIOR LACK OF AN APPROPRIATE ANIMAL MODEL. THROUGH COLLABORATION WITH THE WISCONSIN NATIONAL PRIMATE RESEARCH CENTER, OUR LABORATORY HAS ACCESS TO THE COMMON MARMOSET (CALLITHRIX JACCHUS, CJ), A RECENTLY DEVELOPED KSHV NON-HUMAN PRIMATE MODEL THAT IS SUSCEPTIBLE TO KSHV ORAL INFECTION, AND UNDER IMMUNOSUPPRESSION ACQUIRES KS-LIKE SKIN LESIONS. THE OBJECTIVE OF THIS APPLICATION IS TO ELUCIDATE THE MINIMUM GPS REQUIRED TO INITIATE PRIMARY ORAL INFECTION IN VIVO, AS A PREREQUISITE TO SELECTING KEY GPS FOR DEVELOPING AN EFFECTIVE PROPHYLACTIC VACCINE CANDIDATE. THIS APPLICATION BUILDS ON DR. OGEMBO’S RECENTLY COMPLETED NCI K01 CA184388-05 RESEARCH ON KSHV ENTRY MECHANISMS AND VACCINE DEVELOPMENT. RECENTLY, WE SHOWED THAT IN VITRO, THE KSHV GLYCOPROTEIN GH/GL IS ESSENTIAL FOR VIRAL INFECTION OF EPITHELIAL, ENDOTHELIAL, AND FIBROBLASTS CELLS, BUT NOT B CELLS. NOTABLY, WE AND OTHERS HAVE ALSO SHOWN THAT BOTH MONOCLONAL AND POLYCLONAL ABS TO KSHV GLYCOPROTEINS GB, GH/GL, AND GPK8.1, CAN NEUTRALIZE KSHV INFECTION OF DIVERSE PERMISSIVE HUMAN CELLS IN VITRO. BUILDING ON THIS SUCCESS, WE GENERATED KSHV DELETION MUTANTS LACKING THE FOUR GLYCOPROTEINS THOUGHT TO BE CRITICAL FOR VIRAL ENTRY (GB, GH/GL, GPK8.1) AND VARIOUS MONOCLONAL ANTIBODIES SPECIFIC TO THESE GPS. IN THIS PROJECT, WE WILL USE HUMAN EX VIVO SAMPLES AND THE CJ KSHV MODEL TO TEST THE HYPOTHESIS THAT GB AND GH/GL ARE CRITICAL FOR KSHV IN VIVO ORAL TRANSMISSION. THE PREMISE OF OUR PROPOSAL IS BUILT ON STRONG EVIDENCE THAT 1) KSHV CAN INFECT CJ, WHICH DEVELOP KS-LIKE SKIN LESIONS, AND 2) ABS AGAINST THE KSHV GLYCOPROTEINS GB AND GH/GL CAN NEUTRALIZE KSHV INFECTION IN VITRO AND EX VIVO. FURTHERMORE, THE PERMISSIVENESS TO KSHV INFECTION OF HUMAN CELLS EX VIVO AND CJ MAKES THESE PLATFORMS IDEAL TO TEST THE KSHV GP REQUIREMENTS FOR INFECTION. SUCCESSFUL COMPLETION OF THE PROPOSED STUDY WILL ELUCIDATE THE MINIMUM KSHV GPS REQUIRED FOR PRIMARY INFECTION IN EX VIVO AND IN VIVO MODELS, ADVANCING OUR LONG-TERM GOAL OF DEFINING THE INITIAL STEPS IN KSHV INFECTION OF HUMANS AND THE ROLE OF ANTIBODIES IN PROTECTING AGAINST THE EARLY STEPS OF KSHV TRANSMISSION. THIS WILL ULTIMATELY INFORM DESIGN AND DEVELOPMENT OF PROPHYLACTIC VACCINES THAT CAN PREVENT KSHV INFECTION AND ITS ASSOCIATED CANCERS.

CAPITAL DEVELOPMENT

PURPOSE: TO PROVIDE GRANTS TO COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS (CDFIS) FOR THE FOLLOWING PURPOSES 1) TO EXPAND LENDING, GRANT MAKING AND INVESTMENT ACTIVITIES IN LOW OR MODERATE INCOME COMMUNITIES AND TO BORROWERS THAT HAVE HISTORICALLY EXPERIENCED SIGNIFICANT UNMET CAPITAL AND FINANCIAL SERVICES NEEDS AND WERE DISPROPORTIONATELY IMPACTED BY THE COVID 19 PANDEMIC; AND 2) TO ENABLE CDFIS TO BUILD ORGANIZATIONAL CAPACITY AND ACQUIRE TECHNOLOGY, STAFF, AND OTHER TOOLS NECESSARY TO ACCOMPLISH THE ACTIVITIES UNDER A CDFI ERP AWARD. PLANNED ACTIVITIES: ELIGIBLE ACTIVITIES INCLUDE FINANCIAL PRODUCTS, FINANCIAL SERVICES, DEVELOPMENT SERVICES, GRANTS, LOAN LOSS RESERVES AND CAPITAL RESERVES THAT MAY BE USED TO MITIGATE THE IMPACT OF THE COVID 19 PANDEMIC ON UNEMPLOYMENT, CHILDCARE, HEALTHCARE, MENTAL HEALTHCARE, AFFORDABLE HOUSING, AFFORDABLE HOUSING FINANCE, SMALL BUSINESS, SMALL FARMS, BROADBAND INTERNET, AND FOOD SUFFICIENCY. IN ADDITION, TO SUPPORT CDFIS IN BUILDING THEIR CAPACITY TO RESPOND TO THE ECONOMIC IMPACT OF COVID 19, CDFI ERP AWARDS MAY BE USED FOR COMPENSATION PERSONAL SERVICES; COMPENSATION FRINGE BENEFITS; PROFESSIONAL SERVICE COSTS; TRAVEL COSTS; TRAINING AND EDUCATION COSTS; EQUIPMENT; SUPPLIES. END GOALS: EXPANDED FINANCING FOR LOW TO MODERATE INCOME COMMUNITIES AND INDIVIDUALS THAT HAVE HISTORICALLY EXPERIENCED SIGNIFICANT UNMET CAPITAL AND FINANCIAL SERVICES NEEDS AND WERE DISPROPORTIONATELY IMPACTED BY THE COVID 19 PANDEMIC INCLUDING SPECIFIC DESIGNATED COVID IMPACTED CDFI ERP ELIGIBLE GEOGRAPHIES AS AREAS THAT MAY BENEFIT FROM CDFI ERP ASSISTANCE. BENEFICIARIES: CERTIFIED CDFIS WHICH MAY BE FOR PROFIT ORGANIZATION, PRIVATE NONPROFIT INSTITUTION/ORGANIZATION, AND OTHER PRIVATE INSTITUTION/ORGANIZATION, AS DEFINED IN 12 C.F.R. 1805, AND LOW AND MODERATE INCOME INDIVIDUALS AND FAMILIES. SUBRECIPIENTS: THERE ARE NO SUBRECIPIENTS FOR THIS PROGRAM. BROADBAND: SPECIFIC ACTIVITIES RELATING TO BROADBAND USAGE ARE NOT KNOWN AT THE TIME OF AWARD. REASON/PURPOSE OF MODIFICATION: NOT APPLICABLE.

NEURAL STEM CELL MEDIATED CE-CPT11 THERAPY FOR NEUROBLASTOMA

VA IS PROVIDING PER DIEM FUNDING TO ASSIST WITH THE OPERATIONAL COSTS ASSOCIATED WITH TRANSITIONAL HOUSING BEDS FOR HOMELESS VETERANS.

DEVELOPMENT OF SMALL MOLECULE INHIBITORS AND BIOLOGIC AGENTS FOR TREATMENT OF GLIOBLASTOMA USING INTRACEREBRAL MICRODIALYSIS AND SIGNATURES OF VULNERABILITY - PROJECT SUMMARY - OVERALL THE OVERALL GOAL OF THIS GLIOBLASTOMA (GBM) THERAPEUTICS NETWORK (GTN) U19 APPLICATION FROM CITY OF HOPE, TRANSLATIONAL GENOMICS RESEARCH INSTITUTE, AND UNIVERSITY OF ALABAMA AT BIRMINGHAM IS TO DEVELOP SUPERIOR TREATMENTS FOR PATIENTS WITH GBM, THE MOST COMMON AND AGGRESSIVE PRIMARY BRAIN TUMORS IN ADULTS. EFFECTIVE TREATMENTS REMAIN ELUSIVE AND PATIENTS ARE RARELY CURED WITH STANDARD THERAPIES. THIS GTN U19 APPLICATION EMBODIES A UNIQUE COMBINATION OF APPROACHES DESIGNED TO SIGNIFICANTLY ADVANCE THE TREATMENT OF PATIENTS WITH GBM BY ADDRESSING TUMOR HETEROGENEITY, BLOOD-BRAIN BARRIER PENETRATION, AND THE IMMUNOSUPPRESSIVE GBM TUMOR MICROENVIRONMENT. THE THREE PROPOSED RESEARCH PROJECTS WILL TRANSLATE THERAPEUTIC AGENTS FROM PRECLINICAL DEVELOPMENT, THROUGH IND-ENABLING STUDIES, AND INTO PHASE I CLINICAL STUDIES IN ADULT PATIENTS WITH GBM. EACH PROJECT IS BASED ON NOVEL MOLECULAR PRECLINICAL STUDIES WITH SMALL-MOLECULE INHIBITORS AND IMMUNOMODULATORY AGENTS THAT USE SIGNATURE-GUIDED ASSESSMENT AND TREATMENTS. SPECIFIC GOALS OF THE PROJECTS ARE: PROJECT 1. DEVELOP AND CLINICALLY TEST AN ENGINEERED ONCOLYTIC HERPES VIRUS EXPRESSING A FULL- LENGTH ANTI-CD47 MONOCLONAL ANTIBODY FOR TREATMENT OF GBM. PROJECT 2. DEVELOP AND CLINICALLY TEST TASQUINIMOD AS AN ADJUNCT TO ENHANCE THE EFFICACY OF ANTI-GBM IMMUNOTHERAPIES ADMINISTERED PERI-OPERATIVELY. PROJECT 3. DEVELOP AND CLINICALLY TEST A MOLECULAR “SIGNATURES OF VULNERABILITY” GUIDED TREATMENT OF GBM WITH NEDDYLATION INHIBITOR PEVONEDISTAT. IN ADDITION, THIS U19 APPLICATION PROPOSES STRATEGIES THAT WILL ADDRESS MAJOR BARRIERS IN DRUG DEVELOPMENT BY INCORPORATING TWO INNOVATIVE RESEARCH TOOLS: 1) INTRACEREBRAL MICRODIALYSIS TO RATIONALLY SELECT APPROPRIATE SYSTEMICALLY ADMINISTERED THERAPIES FOR TESTING IN GBM PATIENTS AND 2) NEXT GENERATION EXOME AND TRANSCRIPTOME SEQUENCING TO IDENTIFY MOLECULAR “SIGNATURES OF VULNERABILITY” THAT CAN GUIDE APPROPRIATE PATIENT SELECTION FOR CLINICAL TRIAL ENROLLMENT. THESE ANALYTICAL CAPABILITIES WILL ENABLE US TO QUANTIFY CNS DRUG PENETRATION AND DISSECT GENOMIC HETEROGENEITY IN TUMOR AND STROMAL CELLS IN THE PROPOSED CLINICAL TRIALS. ALSO, TWO OF THE PROPOSED PROJECTS LEVERAGE CITY OF HOPE’S GMP FACILITIES TO MANUFACTURE BIOLOGICAL AGENTS AND SMALL MOLECULES THAT WILL BE TESTED IN ADULT GBM PATIENTS FOR THE FIRST TIME. IN SUMMARY, THE INNOVATIVE PROJECTS AND SHARED RESOURCES CORES IN THIS APPLICATION COMBINE OUR STRENGTHS IN BASIC, TRANSLATIONAL, AND CLINICAL RESEARCH IN A HIGHLY COLLABORATIVE SETTING THAT PROMOTES THE SHARING OF IDEAS, RESULTS, RESOURCES, AND CLINICAL POPULATIONS TO DEVELOP EFFECTIVE TREATMENTS FOR GBM. IF SUCCESSFUL, DATA GENERATED BY THESE STUDIES HAVE THE POTENTIAL TO TRANSFORM THE TREATMENT OF ADULT GBM PATIENTS BY INTRODUCING NEW AGENTS THAT CIRCUMVENT TUMOR HETEROGENEITY AND IMMUNOSUPPRESSION.

UACCHT INSTITUTIONAL CARES ACT REQUEST

VALIDATION OF EPIGENOMIC BIOMARKERS FOR THYROID CANCER DIAGNOSTICS - PROJECT SUMMARY/ABSTRACT EACH YEAR, UP TO 50,000 PATIENTS IN THE UNITED STATES RECEIVE UNNECESSARY THYROIDECTOMIES. THESE UNNECESSARY THYROIDECTOMIES ARE DUE TO DIFFICULTIES IN PREOPERATIVELY DISTINGUISHING BENIGN THYROID NODULES FROM THYROID CANCERS. IN PRELIMINARY DATA, WE DEVELOPED AN EPIGENETIC TEST THAT SHOWS PROMISE TO DISTINGUISH BENIGN VERSUS MALIGNANT THYROID NODULES. HERE, WE WILL RIGOROUSLY TEST AND VALIDATE THE ABILITY OF OUR EPIGENETIC BIOMARKERS TO EVALUATE THE BIOLOGIC AGGRESSIVENESS OF THYROID NODULES AND DETERMINE WHETHER THE NEW EPIGENETIC TESTING WILL IMPROVE THYROID NODULE MANAGEMENT TOWARDS THE ERADICATION OF UNNECESSARY THYROIDECTOMIES. CURRENT MOLECULAR DIAGNOSTICS FOR INDETERMINATE THYROID NODULES, WHILE PROVIDING SOME IMPROVEMENT, HAVE NOT ELIMINATED THE UNNECESSARY THYROIDECTOMIES. CURRENT MOLECULAR DIAGNOSTICS ARE BASED ON MOLECULAR DIFFERENCES BETWEEN NORMAL THYROID TISSUE AND THYROID CANCER. HOWEVER, BENIGN THYROID NODULES CAN CONTAIN MANY MOLECULAR ALTERATIONS INCLUDING GENE FUSIONS AND MUTATIONS. AS A RESULT, OVER HALF OF THYROID NODULES WITH A SIGNIFICANT CANCER RISK ACCORDING TO THE CURRENT MOLECULAR CLASSIFIERS ARE FOUND TO BE BENIGN AFTER THYROIDECTOMY. IN OUR PUBLISHED PRELIMINARY DATA, WE PERFORMED A GENOME-WIDE DNA METHYLATION ANALYSIS OF 109 SURGICALLY EXCISED THYROID NODULES AND ADJACENT BENIGN TISSUE. WE FOUND THAT THE DNA METHYLATION PATTERN IN BENIGN NODULES IS DIFFERENT FROM THYROID CANCER AND NORMAL THYROID. BASED ON THE DNA METHYLATION PATTERN SPECIFIC TO BENIGN NODULES AND THE DNA METHYLATION PATTERN SPECIFIC TO THYROID CANCER, WE DEVELOPED THE DIAGNOSTIC DNA METHYLATION SIGNATURE (DDMS) APPROACH TO DISTINGUISH BETWEEN BENIGN VERSUS MALIGNANT NODULES. IN A RETROSPECTIVE PILOT STUDY PERFORMED UNDER 1R21CA223367, WE DEVELOPED DDMS FURTHER (DDMS-2). WE TESTED THE ABILITY OF THE DDMS-2 ASSAY TO DISTINGUISH BENIGN FROM MALIGNANT SURGICALLY EXCISED THYROID NODULES (N=121). IN THIS PILOT STUDY, DDMS- 2 HAD AN ESTIMATED POSITIVE PREDICTIVE VALUE (PPV) OF 96% AND A NEGATIVE PREDICTIVE VALUE (NPV) OF 98%. GUIDED BY OUR PRELIMINARY DATA, WE HYPOTHESIZE THAT DDMS (I) CAN BE SUCCESSFULLY USED FOR MOLECULAR THYROID CANCER DIAGNOSTICS OF PRE-OPERATIVE THYROID NODULE ASPIRATIONS; (II) WILL HAVE SUPERIOR PERFORMANCE IN COMPARISON TO CURRENT THYROID CANCER MOLECULAR TESTING AND (III) CAN AFFECT PHYSICIAN DECISION-MAKING TOWARDS ELIMINATION OF UNNECESSARY THYROIDECTOMIES. WE WILL ACCOMPLISH OUR OVERALL OBJECTIVE BY PURSUING THE FOLLOWING SPECIFIC AIMS: AIM 1: TO PERFORM ANALYTICAL VALIDATION OF THE DDMS-2 ASSAY. AIM 2: TO DETERMINE THE DDMS-2 ACCURACY IN A PROSPECTIVE COHORT OBTAINED FROM 7 MEDICAL CENTERS AND CONTAINING 1450 THYROID NODULE ASPIRATIONS INCLUDING 800 ASPIRATIONS WITH INDETERMINATE CYTOPATHOLOGY. AIM 3: TO COMPARE THE DIAGNOSTIC ACCURACY BETWEEN DDMS- 2 AND TWO CURRENT THYROID CANCER MOLECULAR DIAGNOSTIC APPROACHES AND TO EVALUATE HOW THE KNOWLEDGE OF THE DDMS-2 RESULTS IMPACTS CLINICAL MANAGEMENT OF THYROID NODULES. THE DEVELOPMENT OF A MORE ACCURATE ASSAY TO DISTINGUISH BENIGN AND MALIGNANT THYROID NODULES WILL ADDRESS CURRENT CLINICAL LIMITATIONS AND REDUCE THE NUMBER OF NEEDLESS THYROIDECTOMIES AND ASSOCIATED MORBIDITIES.

GERIATRIC ONCOLOGY RESEARCH INFRASTRUCTURE TO IMPROVE CLINICAL CARE

HEALTH CENTER CLUSTER

HEALTH SECURITY ACTIVITY

RYAN WHITE PART C OUTPATIENT EIS PROGRAM

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ROLE OF THE XBP1S/GFAT1 AXIS IN PATHOLOGICAL CARDIAC REMODELLING

KSHV SUBUNIT VACCINE CANDIDATES TO ELICIT POTENT HUMORAL IMMUNE REPONSES AGAINST KSHV INFECTION - PROJECT SUMMARY KAPOSI SARCOMA-ASSOCIATED HERPESVIRUS (KSHV) HAS BEEN CLASSIFIED AS A DIRECT CARCINOGEN BY THE INTERNATIONAL AGENCY FOR RESEARCH ON CANCER BECAUSE OF ITS ABILITY TO CAUSE KAPOSI SARCOMA (KS) AND TWO RARE TYPES OF B-CELL LYMPHOMA. KS FREQUENTLY OCCURS AMONG IATROGENIC OR HIV/AIDS-INDUCED IMMUNOSUPPRESSED INDIVIDUALS. TO DATE, THERE IS NO LICENSED KSHV VACCINE THAT CAN PREVENT PRIMARY INFECTION AND SUBSEQUENT MALIGNANCIES. OUR OBJECTIVE IN THIS APPLICATION IS TO OPTIMIZE THE INCLUSION OF KEY KSHV GLYCOPROTEINS (GPS), WHICH ARE INVOLVED IN EPITHELIAL, ENDOTHELIAL, FIBROBLAST AND B-CELL ENTRY, INTO MULTIVALENT SUBUNIT VACCINE CANDIDATES THAT CAN STIMULATE NEUTRALIZING ANTIBODY (NAB) IMMUNE RESPONSES TO PREVENT OR LIMIT KSHV INFECTION AND KSHV+ CANCERS IN VIVO. THIS APPLICATION BUILDS ON MY RECENTLY COMPLETED NCI K01 CA184388-05 RESEARCH ON KSHV ENTRY MECHANISMS AND VACCINE DEVELOPMENT. RECENTLY, WE SHOWED THAT IN VITRO, THE KSHV GLYCOPROTEIN GH IS ESSENTIAL FOR VIRAL INFECTION OF EPITHELIAL, ENDOTHELIAL, AND FIBROBLASTS CELLS, BUT NOT B CELLS. NOTABLY, WE AND OTHER HAVE ALSO SHOWN THAT BOTH MONOCLONAL AND POLYCLONAL ABS TO KSHV GLYCOPROTEINS K8.1, GB, AND GH/GL CAN NEUTRALIZE KSHV INFECTION OF DIVERSE PERMISSIVE HUMAN CELLS IN VITRO. BUILDING ON THIS SUCCESS, WE HAVE GENERATED QUADRIVALENT VIRUS-LIKE PARTICLES (KSHV-LPS) INCORPORATING THE FOUR GLYCOPROTEINS CRITICAL FOR VIRAL ENTRY (K8.1, GB AND GH/GL). IN THIS APPLICATION WE WILL USE WILD-TYPE AND HUMANIZED MICE AND COMMON MARMOSET (CALLITHRIX JACCHUS) MODELS TO TEST THE HYPOTHESIS THAT PURIFIED KSHV-LPS DELIVERED DIRECTLY OR THROUGH IMMUNIZATION WITH A MODIFIED VACCINIA ANKARA VECTOR (MVA-KSHV-LPS) WILL ELICIT ROBUST PROTECTIVE NAB RESPONSES TO KSHV INFECTION AND ITS ASSOCIATED MALIGNANCIES. THE PREMISE OF OUR PROPOSAL IS BUILT ON STRONG EVIDENCE THAT 1) INFECTION WITH KSHV DOES NOT OCCUR DURING EARLY CHILDHOOD, AS IS TYPICAL FOR OTHER HERPESVIRUSES, OPENING A WINDOW OF OPPORTUNITY FOR VACCINATION AND 2) ABS AGAINST THE KSHV GLYCOPROTEINS K8.1, GB, AND GH/GL CAN NEUTRALIZE KSHV INFECTION. FURTHERMORE, THE PERMISSIVENESS OF HUMANIZED MICE AND MARMOSETS TO KSHV INFECTION OFFERS AN IDEAL PLATFORM TO TEST CANDIDATE VACCINES. THUS, A POLYVALENT VACCINE THAT INDUCES PROPHYLACTIC NEUTRALIZING ABS RESPONSES WILL NOT ONLY BE AN INVALUABLE CANDIDATE VACCINE IN PREVENTING KSHV INFECTION, BUT ALSO OF UTMOST IMPORTANCE IN PREVENTING KSHV-ASSOCIATED DISEASES. WE WILL PROVIDE EVIDENCE FOR THE SAFETY OF OUR CANDIDATE KSHV VACCINE BASED ON THREE PRE-CLINICAL ANIMAL MODELS AS PREREQUISITE DATA FOR AN IND APPLICATION FOR A PHASE I CLINICAL TRIAL. IN THE LONG TERM, THE SUCCESS OF OUR APPROACH WILL INTRODUCE A NEW VACCINE TO THE MARKET WITH A POTENTIAL FOR REDUCING GLOBAL INCIDENCE OF KSHV+ MALIGNANCIES (>44,000 CASES/YEAR), AND THE POSSIBILITY OF LIMITING KSHV INFECTION AND ASSOCIATED MALIGNANCIES IN DEVELOPING COUNTRIES OR ERADICATING THEM FROM DEVELOPED COUNTRIES WHERE KSHV SEROPREVALENCE IS <10%.

THE SSVF PROGRAM'S PURPOSE IS TO PROVIDE SUPPORTIVE SERVICES GRANTS TO PRIVATE NON-PROFIT ORGANIZATIONS AND CONSUMER COOPERATIVES, WHO WILL COORDINATE OR PROVIDE SUPPORTIVE SERVICES TO VERY LOW-INCOME VETERAN FAMILIES WHO ARE RESIDING IN PERMANENT HOUSING, ARE HOMELESS AND SCHEDULED TO BECOME RESIDENTS OF PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD; OR AFTER EXITING PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD, ARE SEEKING OTHER HOUSING THAT IS RESPONSIVE TO SUCH VERY LOW-INCOME VETERAN FAMILY'S NEEDS AND PREFERENCES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES.

THE SSVF PROGRAM'S PURPOSE IS TO PROVIDE SUPPORTIVE SERVICES GRANTS TO PRIVATE NON-PROFIT ORGANIZATIONS AND CONSUMER COOPERATIVES, WHO WILL COORDINATE OR PROVIDE SUPPORTIVE SERVICES TO VERY LOW-INCOME VETERAN FAMILIES WHO ARE RESIDING IN PERMANENT HOUSING, ARE HOMELESS AND SCHEDULED TO BECOME RESIDENTS OF PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD; OR AFTER EXITING PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD, ARE SEEKING OTHER HOUSING THAT IS RESPONSIVE TO SUCH VERY LOW-INCOME VETERAN FAMILY'S NEEDS AND PREFERENCES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES.

PESACH TIKVAH CCBHC

HOMELESS PREVENTION

VA IS PROVIDING PER DIEM FUNDING TO ASSIST WITH THE OPERATIONAL COSTS ASSOCIATED WITH TRANSITIONAL HOUSING BEDS FOR HOMELESS VETERANS.

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PHASE I MOLECULAR AND CLINCAL PHARMACODYNAMIC TRIALS

GERMLINE AND TUMOR GENOMIC ANALYSES OF BREAST CANCER IN LATINAS

TECHNOLOGY-ENABLED ACTIVATION OF SKIN CANCER SCREENING FOR HEMATOPOIETIC CELL TRANSPLANTATION SURVIVORS AND THEIR PRIMARY CARE PROVIDERS

SELF-MANAGEMENT TO OPTIMIZE SURVIVORSHIP CARE AND OUTCOMES IN LUNG AND COLORECTAL CANCER

1/2 DRUG DEVELOPMENT AND CAPACITY BUILDING: A UCR/COH-CCC PARTNERSHIP - THE UNITED STATES (U.S.) HAS LED THE WORLD IN DRUG DISCOVERY FOR OVER 50 YEARS. WHILE THIS IS A SIGNIFICANT ACCOMPLISHMENT, U.S. DRUGS HAVE BEEN ALMOST EXCLUSIVELY OPTIMIZED AND TESTED IN NON-HISPANIC EUROPEAN- AMERICANS AND BEEN MINIMALLY EVALUATED IN MEN- OR WOMEN-OF-COLOR. AS A RESULT, DRUGS THAT WORK WELL IN NON- HISPANIC EUROPEAN-AMERICANS (ANGLOS), MAY HAVE UNEXPECTED TOXICITY OR DECREASED EFFICACY IN MOST OF THE WORLD’S POPULATION. DISPARITIES IN U.S. DRUG DEVELOPMENT OCCUR THROUGHOUT THE ENTIRE DRUG DISCOVERY PIPELINE. ONLY A SMALL NUMBER OF BASIC SCIENTISTS ARE LATINO/HISPANIC- OR AFRICAN-AMERICAN. INITIAL DRUG DEVELOPMENT AND OPTIMIZATION TAKES PLACE IN CELL LINES DERIVED FROM ANGLOS. LESS THAN 2% OF PHYSICIANS CONDUCTING CLINICAL TRIALS ARE LATINO/HISPANIC- OR AFRICAN-AMERICAN6. MOST CLINICAL TRIALS PARTICIPANTS ARE ANGLOS. YET, NEW DRUGS ARE FDA APPROVED FOR LATINOS/HISPANICS- AND AFRICAN-AMERICANS/AFRICANS WITHOUT SUFFICIENT TESTING. IT IS UNACCEPTABLE THAT DRUGS ARE DEVELOPED BY, AND OPTIMIZED FOR, ONLY A FRACTION OF OUR CITIZENS. IN THIS U54 PARTNERSHIP WE AIM TO DEVELOP THE RESOURCES, INFRASTRUCTURE, AND TRAINING TO MENTOR THE NEXT GENERATION OF RESEARCHERS THAT REFLECT THE DIVERSITY OF OUR CATCHMENT AREA. BUILDING ON OUR SUCCESSFUL P20 GRANT, HERE IN THIS U54 PARTNERSHIP, UCR AND COHCCC AIM TO DEVELOP THE COLLABORATIONS, RESOURCES, AND TRAINING PROGRAMS TO REDUCE DISPARITIES IN DRUG DEVELOPMENT THROUGHOUT THE ENTIRE DRUG DEVELOPMENT PIPELINE. OUR GOAL IS FOR THIS PROGRAM TO BECOME A FOCAL POINT FOR UCR AND COHCCC TO MENTOR AND TRAIN A DIVERSE FORCE OF CANCER BIOLOGISTS AND ADDRESS THE DISPARITIES IN CANCER THERAPEUTICS AND DRUG DEVELOPMENT. ALREADY, OUR P20 HAS FOSTERED JOINT R01 GRANTS, K01 GRANTS, AND PRE-/POST-DOCTORAL FELLOWSHIPS. BOTH INSTITUTIONS ARE HIGHLY COMMITTED - COHCCC CONTRIBUTED OVER $800K TO OUR P20 GRANT AND WILL CONTRIBUTE $250K/YEAR TO ENSURE THE SUCCESS OF THIS U54 PARTNERSHIP. AIM 1 WILL STRENGTHEN UCR’S CANCER RESEARCH CAPACITY AND DEVELOP THE RESOURCES TO INCREASE UCR/COHCCC’S ABILITY TO JOINTLY DEVELOP THERAPEUTIC AGENTS OPTIMIZED FOR THE DIVERSE POPULATIONS IN OUR CATCHMENT AREA. AIM 2 WILL INCREASE THE CAPACITY OF UCR AND COHCCC TO JOINTLY DEVELOP DRUGS THAT TARGET DISPARITIES IN SURVIVAL AFFECTING THE DIVERSE INDIVIDUALS LIVING IN OUR SOUTHERN CALIFORNIA COMMUNITIES. AIM 3 WILL PROVIDE THE TRAINING, OPPORTUNITY, AND MENTORSHIP TO ENSURE THAT THE NEXT GENERATION OF THERAPEUTIC SCIENTISTS AND CLINICAL TRIALISTS REFLECT THE DIVERSITY OF SOUTHERN CALIFORNIA.

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HOPE ENTERPRISE CORPORATION'S CHARTER SCHOOL FACILITIES FUND

REINTEGRATION OF EX-OFFENDERS

PESACH TIKVAH CCBHC-IA - PESACH TIKVAH CCBHC WILL PROVIDE A BROAD RANGE OF ACCESSIBLE, AFFORDABLE, CULTURALLY APPROPRIATE, BILINGUAL INTEGRATED OUTPATIENT MH, PHYSICAL HEALTH MONITORING, SUD SERVICES AND CARE COORDINATION.TO SERVE AN UNDUPLICATED 800 INDIVIDUALS WITH CCBHC IA GRANT FUNDING (200 ANNUALLY). SERVICES WILL BE DELIVERED IN THE WILLIAMSBURG AND BOROUGH PARK NEIGHBORHOODS IN BROOKLYN, NEW YORK TO ADULTS WITH SERIOUS MENTAL ILLNESS (SMI), SUBSTANCE USE DISORDERS (SUD), OPIOID USE DISORDERS (OUD) AND CO-OCCURRING DISORDERS (COD), AS WELL AS CHILDREN AND TEENS WITH SERIOUS EMOTIONAL DISORDERS (SED) AND THEIR FAMILY MEMBERS. PT WILL FOCUS ON PEOPLE OF ORTHODOX JEWISH/HASIDIC (ORTHODOX) ETHNIC GROUP TO REDUCE DISPARITIES IN HEALTHCARE ACCESS AND OUTCOMES. ORTHODOX TYPICALLY HAVE LARGE FAMILY SIZES AND STRUGGLE WITH SIGNIFICANT DISPARITIES IN INCOME, HEALTHCARE ACCESS AND OUTCOMES. THEY EXPERIENCE HEIGHTENED BARRIERS TO ACCESSING CARE DUE TO HIGH RATES OF STIGMA, LOW SOCIOECONOMIC STATUS, CULTURAL AND LANGUAGE BARRIERS. GRANT GOALS INCLUDE 1) EXPAND ACCESS TO WELL-COORDINATED, INTEGRATED SERVICES BY INCREASING AVAILABILITY AND CAPACITY OF BEHAVIORAL HEALTH SERVICES, INTEGRATING SUBSTANCE ABUSE SERVICES, AND INTEGRATING PRIMARY CARE SCREENING/MONITORING; 2) SUPPORT RECOVERY BY IMPROVING THE QUALITY OF CARE AND CLINICAL OUTCOMES FOR HIGH-RISK INDIVIDUALS BY IMPLEMENTING EVIDENCE-BASED INTEGRATED MENTAL AND SUD TREATMENT AND PROGRAMMING, TARGETED CARE MANAGEMENT (TCM), COMMUNITY-BASED CARE AND ENHANCED USE OF DATA; AND 3) REDUCE TOTAL COST OF CARE FOR HIGHEST RISK CLIENTS (REDUCING USAGE OF INPATIENT ADMISSIONS, DAYS IN HOSPITAL, ED VISITS) BY INCREASING ACCESS TO INTEGRATED CARE AND USING REAL-TIME DATA TO DRIVE DECISION-MAKING AND PREVENT RELAPSE AND WORSENING OF SYMPTOMS. STRATEGIES/INTERVENTIONS FOR IMPROVEMENT/ADVANCEMENT INCLUDE: 1) IMPROVING MOBILE CRISIS BY HIRING 2 EMTS AFFILIATED WITH A LOCAL VOLUNTEER FIRST RESPONDER ORGANIZATION THAT IS A TRUSTED RESOURCE IN THE POPULATION OF FOCUS. 2) FULLY IMPLEMENT, IMPROVE AND INTEGRATE STANDALONE SUD SERVICES USING EBP FOR 70 INDIVIDUALS IN YEAR 1, 3) ENGAGE IN ADDITIONAL PATIENT MOTIVATION AND OUTREACH TO INCREASE PATIENT PARTICIPATION IN PRIMARY CARE SCREENING AND 4) CONTINUE TO EXPAND TCM PROGRAM TO 100 PATIENTS USING NYS HH MODEL (YEAR 4) SO IT CAN REACH BREAK-EVEN AND BECOME SUSTAINABLE, 6) CONTINUE TO EXPAND COMMUNITY BASED SERVICES AND PEER SUPPORTS BY HIRING AT LEAST 8 ADDITIONAL PSYCHOSOCIAL REHAB AND/OR PEER PROVIDERS, 7) IMPLEMENT ADDITIONAL SUPERVISION AND COACHING TO 75 STAFF TO ENSURE FIDELITY TO EBPS, 8) TRAIN 75 STAFF AND MAKE GOAL OF SUPERVISION TO INCREASE USE OF SCREENING INSTRUMENTS TO ENABLE MEASUREMENT BASED CARE (MBP), 9) LEVERAGE PSYCKES AND HEALTHIX (NYS/NYC ELECTRONIC HEALTH INFORMATION EXCHANGES) TO IMPROVE CARE TRANSITIONS, 10) MAINTAIN OUTREACH COORDINATOR TO UPDATE AND MAINTAIN CARE COORDINATION AGREEMENTS WITH AT LEAST 20 PARTNERS/REQUIRED CARE SETTINGS, PER CRITERIA, 11) MAINTAIN DATA ANALYST TO UTILIZE BUSINESS INTELLIGENCE AND ADD DATA DASHBOARDS TO ENABLE RAPID ACCESS TO DATA AND MEANINGFUL USE OF DATA, 12) UPDATE AND IMPLEMENT A DATA-DRIVEN CQI PLAN BY YEAR 2 OF THE GRANT, 13) INCREASE USE OF MEASUREMENT-BASED CARE BY 25% FROM BASELINE THROUGH USE OF SCREENING INSTRUMENTS (I.E. PHQ9, GAD7, AUDITC), 14) PLAN AND COMPLETE A NEEDS ASSESSMENT THAT WILL INFORM FURTHER DEVELOPMENT OF PROGRAMS AND SUPPORTS TO FILL SERVICE GAPS IN 2024.

CERTIFIED COMMUNITY BEHAVIORAL HEALTH CLINIC EXPANSION GRANTS - AMANDA LUCKETT MURPHY HOPEWELL CENTER (ALMHC), A COMMUNITY MENTAL HEALTH CENTER, REQUESTS THE TWO-YEAR CERTIFIED COMMUNITY BEHAVIORAL HEALTH CLINIC EXPANSION GRANT FUNDING TO FULLY IMPLEMENT A CCBHC MODEL TO MEET THE BEHAVIORAL HEALTH (BH) NEEDS OF CHILDREN, ADULTS AND FAMILIES WITHIN ST. LOUIS-NORTH CITY SERVICE AREA. ALMHC WILL PURSE THREE OBJECTIVES TO THIS GRANT: A) INCREASE ACCESS TO BEHAVIORAL HEALTH SERVICES BY EXPANDING CAPACITY, INFRASTRUCTURE, AND EXPERTISE; B) INCREASE THE INTEGRATION OF BEHAVIORAL AND PHYSICAL HEALTH FOR INDIVIDUALS SERVED; AND C) EXPAND THE UTILIZATION OF EVIDENCE-BASED PRACTICES. ALMHC WILL SERVE ADULTS WITH SERIOUS MENTAL ILLNESS (SMI), CHILDREN AND ADOLESCENTS WITH SERIOUS EMOTIONAL DISTURBANCE (SED), SUBSTANCE USE DISORDER (SUD), AND CO-OCCURRING DISORDER (COD). FOCUSED OUTREACH TO SUB-POPULATIONS WILL INCLUDE AFRICAN-AMERICAN INDIVIDUALS, TRANSITION-AGE YOUTH, ARMED FORCES AND VETERANS, AND LGBTQ+ INDIVIDUALS WHO ARE UNDERSERVED AS WELL AS UNDER-INSURED OR UNINSURED. ALMHC CURRENTLY SERVES APPROXIMATELY 3,900 INDIVIDUALS AND WILL SERVE AN ADDITIONAL 525 IN YEAR 1 AND 525 IN YEAR 2; TOTALING 1,050 OVER THE GRANT PERIOD. ALMHC WILL INCREASE CAPACITY AND ACCESS TO SERVICES BY HIRING 2 ADDITIONAL INTAKE AND ASSESSMENT COORDINATORS, 2 ADULT EBP THERAPISTS, 1 YOUTH EBT THERAPIST, 1 VETERANS SERVICES COORDINATOR, AND 2 PEER SPECIALISTS. AN EBP TRAINER WILL BE HIRED TO PROVIDE AND EXPAND EVIDENCE-BASED PRACTICE AWARENESS AND TRAINING FOR AGENCY STAFF AND TO ENHANCE THE SERVICE DELIVERY OF EBP MODELS. THE NORTH CITY AREA IS DESCRIBED AS A LARGE, DENSELY POPULATED, UNDERSERVED URBAN AREA PRIMARILY OCCUPIED BY AFRICAN-AMERICAN RESIDENTS. ST. LOUIS CITY HAD THE HIGHEST PERCENTAGE OF OVERALL POPULATION LIVING IN POVERTY AS COMPARED TO ST. LOUIS COUNTY AND THE STATE. DATA RECORDED IN EASTERN MISSOURI SHOWS 18.3% OF INDIVIDUALS 18 AND OLDER HAD A MENTAL ILLNESS IN THE PAST YEAR WITH 4.2% HAVING A SERIOUS MENTAL ILLNESS (A MENTAL, BEHAVIOR, OR EMOTIONAL DISORDER THAT CAUSES SERIOUS FUNCTIONAL IMPAIRMENT THAT SUBSTANTIALLY INTERFERES WITH, OR LIMITS, ONE OR MORE MAJOR LIFE ACTIVITIES). ADDITIONALLY, 7.8% OF THE ADULT POPULATION EXPERIENCES A SUBSTANCE USE DISORDER (MISSOURI DEPARTMENT OF MENTAL HEALTH 2017). IN RESPONSE TO ACCESS TO CARE CHALLENGES, ALMHC WILL TRANSITION TO A SAME-DAY-ACCESS AND JUST-IN-TIME SERVICE MODEL AS WELL AS IMPLEMENTATION OF THE "WELCOME CENTER' APPROACH AS THE INTRODUCTION TO AGENCY SERVICES. AS A CMHC, ALMHC ALREADY PROVIDES A COMPREHENSIVE ARRAY OF SERVICE AND HAS IMPLEMENTED REQUIRED SERVICES AND UTILIZES DCOS AND A FEW OTHERS. THIS CCBHC EXPANSION FUNDING WILL SUPPORT FULL CCBHC IMPLEMENTATION.

HOPEWELL HEALTH CENTERS - AS PART OF THIS PROJECT, HHC WILL COMPLETE THE GOAL OF FORMALLY CERTIFYING HHC'S COMPREHENSIVE SYSTEM OF CARE AS A CCBHC AND EXPAND TO ALL BEHAVIORAL HEALTH CLINICS IN THE NINE-COUNTY SERVICE AREA IN APPALACHIAN SOUTHEAST OHIO TO INCLUDE 6 CLINICS, 250 UNIQUE STAFF TRAINED, AND 4,000 UNIQUE CLIENTS SERVED ACROSS THE 2 YEAR PERIOD.

PURPOSE: ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING/CONGRESSIONAL DIRECTED SPENDING AWARDS ARE AUTHORIZED UNDER THE CONSOLIDATED APPROPRIATIONS ACT, 2022 PUBLIC LAW 117-328 AND THE EXPLANATORY STATEMENT FOR DIVISION L OF THAT ACT. PROJECTS SELECTED FOR COMMUNITY PROJECT FUNDING/CONGRESSIONAL DIRECTED SPENDING ARE LISTED IN THE JOINT EXPLANATORY STATEMENT (JES) THAT ACCOMPANIES A SPECIFIC FISCAL YEAR’S APPROPRIATIONS ACT OR CONGRESSIONAL RECORD. THE JES LISTS PROJECT, RECIPIENT, STATE, AMOUNT AND CONGRESSIONAL SPONSOR.; ACTIVITIES TO BE PERFORMED: ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING AWARD PROJECTS INCLUDE A WIDE VARIETY OF ACTIVITIES THAT RESULT IN ECONOMIC DEVELOPMENT OR COMMUNITY DEVELOPMENT OUTCOMES. HUD WILL NOT KNOW THE FULL SCOPE OF THE PROJECT UNTIL THE RECIPIENT SUBMITS THE REQUIRED PROJECT NARRATIVE AND CONFIRMS ALIGNMENT WITH THE LANGUAGE AS PROVIDED IN THE CONGRESSIONAL RECORD. TO FIND THE DETAILS OF THE GRANT AWARD AS WRITTEN WITHIN THE CONGRESSIONAL RECORD USE THE FOLLOWING LINK AND PATH SELECTIONS TO GET TO THE DESCRIPTION OF THE ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING GRANTS HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/EDI-GRANTS, SELECT THE FISCAL YEAR OF INTEREST, SCROLL DOWN TO PROGRAM LAWS AND REGULATIONS, UNDER FISCAL YEAR 20XX CONSOLIDATED APPROPRIATIONS ACT, 20XX: CONGRESSIONAL RECORD (JOINT EXPLANATORY STATEMENT).; EXPECTED OUTCOMES: COMPLETION OF THE PROJECT AS DESCRIBED IN THE JOINT EXPLANATORY STATEMENT (JES) PROJECT DESCRIPTION AND SUBSEQUENT APPROVED PROJECT NARRATIVE.; INTENDED BENEFICIARIES: THE PROJECT BENEFICIARIES ARE THE INDIVIDUALS AND/OR ORGANIZATIONS THAT ARE AWARDED GRANT FUNDS OR SERVED BY THE ENTITIES THAT ARE AWARDED GRANT FUNDS AS IDENTIFIED IN THE JES RECIPIENT OR PROJECT DESCRIPTION SECTIONS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

HUMANITARIAN POLICY, STUDIES, ANALYSIS OR APPLICATIONS

CAPITAL MAGNET FUND AWARD

EXTENDING HOPE - LEVERAGING MOBILE TECHNOLOGY AND 24/7 SERVICES TO IMPROVE OUTCOMES. - HOPE COMMUNITY SERVICES, INC. (HOPE) IS A BEHAVIORAL HEALTH CARE ORGANIZATION PROVIDING A BROAD SPECTRUM OF SERVICES THROUGHOUT THE OKLAHOMA CITY METROPOLITAN AREA. HOPE CURRENTLY ASSISTS TREATING A MOSTLY UNDERSERVED AND INDIGENT CLIENT BASE. GRANT FUNDS WILL BE USED TO REDUCE HOSPITALIZATION WITH MOBILE REAL TIME TECHNOLOGY AND IMPLEMENTATION OF A 24-HOUR CRISIS STABILIZATION THROUGH AN URGENT RECOVERY CENTER. FUNDS WILL ALSO BE DEPLOYED TO DEVELOP A COMPREHENSIVE COMMUNITY-BASED RECOVERY OF PEER SUPPORTS, COUNSELING SERVICES, AND FAMILY SUPPORT. HOPE'S GOAL IS TO CONTINUE IMPROVING BEHAVIORAL HEALTH DISPARITIES BY PROVIDING COORDINATED CARE FOR THOSE PERSON LIVING WITH SERIOUS MENTAL ILLNESS, SUBSTANCE ABUSE DISORDERS, CO-OCCURRING MENTAL AND SUBSTANCE DISORDERS, CHILDREN WITH SERIOUS EMOTIONAL DISTURBANCE, ACTIVE MILITARY, AND VETERANS.

AROUND THE CLOCK CRISIS PREVENTION & STABILIZATIONA COMPREHENSIVE 24/7 CRISIS PREVENTION AND TREATMENT CENTER THAT ADDRESS SUBSTANCE MISUSE MENTAL AND PHYSICAL HEALTH. - FHLOC IS A BEHAVIORAL HEALTH CLINIC LICENSED BY THE STATE OF MICHIGAN. THROUGH OUR COMPREHENSIVE 24/7 AROUND THE CLOCK CRISIS PREVENTION & STABILIZATION PROGRAM, WE PROVIDE EVIDENCE-BASED OUTPATIENT TREATMENT FOR INDIVIDUALS WITH SUBSTANCE USE DISORDER, OPIOID USE DISORDER, MENTAL HEALTH AND CO-OCCURRING DISORDER. WE ALSO SERVICE VETERANS AND CHILDREN AND ADOLESCENTS W/SED. WE ARE TEAMED WITH HOSPITAL EMERGENCY ROOMS TO REDUCE RECIDIVISM OF NON-LIFE-THREATENING MENTAL HEALTH AND DRUG RELATED ISSUES TO ALLOW FOR THE TREATMENT OF THOSE WITH LIFE-ALTERING EMERGENCIES. WE ARE LOCATED IN DETROIT, WAYNE COUNTY AND EXPECT TO SERVE MENTAL HEALTH AND SUBSTANCE MISUSE CONSUMERS FROM THE SURROUNDING COUNTIES, INCLUDING: OAKLAND, MACOMB, WASHTENAW, LIVINGSTON, AND MONROE. WE WILL INCREASE THE NUMBER OF CONSUMERS IN TREATMENT FOR SUD, OUD, SMI, AND SED, BY SERVING 150 NEW CLIENTS IN THE FIRST YEAR, OPEN A NEW FACILITY BY THE START OF THE SECOND YEAR, AND SERVE AN ADDITIONAL 300 UNDUPLICATED CLIENTS FROM TWO LOCATIONS BY THE END OF THE SECOND YEAR. THE MOST FUNDAMENTAL MEASUREMENT OF THE PROJECT SUCCESS IS TO INCREASE ACCESS TO AND IMPROVE THE QUALITY OF COMMUNITY MENTAL HEALTH AND SUBSTANCE USE DISORDER TREATMENT SERVICES BY PROVIDING PERSON AND FAMILY CENTERED INTEGRATED SERVICES ON DAY ONE. WE WILL BECOME A CERTIFIED COMMUNITY BEHAVIORAL HEALTH CLINIC WITHIN FOUR MONTHS OF FUNDING AND BEGIN ON-SITE MEDICATION ASSISTED TREATMENT BY TELEMEDICINE WITH THE PRESCRIBING OF BUPRENORPHINE WITHIN 30 DAYS. OUR COUNSELORS AND MEDICAL TEAM WILL REDUCE THE NUMBER OF UNTREATED PERSONS WITH SUD, OUD, SMI, AND SED BY STABILIZING 70% OF NEW CLIENTS WITHIN 90 DAYS AND 85% OF CLIENTS IN PROGRAM FOR SIX MONTHS, WILL BE FREE FROM ILLICIT DRUG USE. WE WILL IMPROVE THE POSITIONING OF CLIENTS IN THE PROGRAM FOR 12 MONTHS BY INCREASING SCORES AS MEASURED BY ASAM AND THE STAGES OF CHANGE IN RELATION TO CLIENTS TREATMENT PLAN GOALS, FROM LOW, MEDIUM, TO HIGH. WE ARE ALSO TEAMED WITH CONNER CREEK SOLUTIONS FOR DETOX SERVICES AND NEW LIGHT RECOVERY CENTER FOR METHADONE MAINTENANCE. OUR GOAL IS TO ADDRESS THE TOTAL NEED OF OUR CLIENTS THROUGH PEER SUPPORT, RESUME BUILDING, JOB TRAINING AND PLACEMENT, AS WELL AS, LIFE SKILLS ENHANCEMENT AND LIFE COACHING WORKSHOPS. TRANSPORTATION IS PROVIDED TO AND FROM CLINICAL APPOINTMENTS AND DOSING FACILITIES, AS WELL AS, FROM THE EMERGENCY ROOM TO FHLOC, WHERE WE PROVIDE A COMFORTABLE PLACE TO TRANSITION THROUGH THE RECOVERY PROCESS WITH TEMPORARY SHELTER, FOOD, SHOWER, AND A CHANGE OF CLOTHES. WE WILL HAVE A NURSE PRACTITIONER AND MEDICAL ASSISTANT ON SITE TO ADDRESS PHYSICAL HEALTH NEEDS AND LICENSED COUNSELORS, TELEPSYCHIATRY FOR MENTAL HEALTH NEEDS, AS WELL AS CASE MANAGEMENT TO LINK CONSUMERS TO REFERRAL SERVICES. SECURITY IS ANOTHER A BIG PART OF OUR SERVICES TO ENSURE THE SAFETY OF OUR STAFF AND CLIENTS IN THE EVENT OF ANY UNFORESEEN CIRCUMSTANCES. OUR CRISIS TEAMS ARE MOBILE AND WILL MAKE HOME VISITS.

CANCER GENETICS PROFESSIONAL EDUCATION IN A GLOBAL COMMUNITY OF PRACTICE

VA IS PROVIDING PER DIEM FUNDING TO ASSIST WITH THE OPERATIONAL COSTS ASSOCIATED WITH TRANSITIONAL HOUSING BEDS FOR HOMELESS VETERANS.

THE BIOLOGY AND DIAGNOSIS OF HNPCC

SANDY DISASTER RELIEF

A MULTIMEDIA SELF-MANAGEMENT INTERVENTION TO PREPARE FAMILY CAREGIVERS AND PATIENTS FOR LUNG CANCER SURGERY

IMPROVE EXISTING AIRPORT

THE SSVF PROGRAM'S PURPOSE IS TO PROVIDE SUPPORTIVE SERVICES GRANTS TO PRIVATE NON-PROFIT ORGANIZATIONS AND CONSUMER COOPERATIVES, WHO WILL COORDINATE OR PROVIDE SUPPORTIVE SERVICES TO VERY LOW-INCOME VETERAN FAMILIES WHO ARE RESIDING IN PERMANENT HOUSING, ARE HOMELESS AND SCHEDULED TO BECOME RESIDENTS OF PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD; OR AFTER EXITING PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD, ARE SEEKING OTHER HOUSING THAT IS RESPONSIVE TO SUCH VERY LOW-INCOME VETERAN FAMILY'S NEEDS AND PREFERENCES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES.

EARLY HEAD START

STRUCTURAL BASIS OF G-PROTEIN SELECTIVITY IN GPCRS USING MULTISCALE DYNAMICS

ROLE OF RECEPTOR FOR ADVANCED GLYCATION END PRODUCT (RAGE) PATHWAY IN BRAIN TUMOR

CAPITAL MAGNET FUND AWARD

INVESTIGATION OF THE ROLES OF NUCLEAR RECEPTOR FXR IN HEPATOCELLULAR

COMBINED BREAST MRI/BIOMARKER STRATEGIES TO IDENTIFY AGGRESSIVE BIOLOGY

EPIGENETIC DAMAGE IN WOMEN LIVING IN LA FOOD-DESERT ZIP CODES

CLINICAL EVALUATION OF CHLOROTOXIN-REDIRECTED CHIMERIC ANTIGEN RECEPTOR (CAR) T CELLS FOR TREATMENT OF GLIOBLASTOMA

THE SSVF PROGRAM'S PURPOSE IS TO PROVIDE SUPPORTIVE SERVICES GRANTS TO PRIVATE NON-PROFIT ORGANIZATIONS AND CONSUMER COOPERATIVES, WHO WILL COORDINATE OR PROVIDE SUPPORTIVE SERVICES TO VERY LOW-INCOME VETERAN FAMILIES WHO ARE RESIDING IN PERMANENT HOUSING, ARE HOMELESS AND SCHEDULED TO BECOME RESIDENTS OF PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD; OR AFTER EXITING PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD, ARE SEEKING OTHER HOUSING THAT IS RESPONSIVE TO SUCH VERY LOW-INCOME VETERAN FAMILY'S NEEDS AND PREFERENCES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES.

FINANCIAL ASSISTANCE AWARD

MECHANISM OF ESTROGEN INDEPENDENT PROLIFERATION IN ER+ BREAST CANCER CELLS - ABSTRACT COMBINING CYCLIN-DEPENDENT KINASE (CDK) INHIBITORS WITH ENDOCRINE THERAPY IMPROVES OUTCOMES FOR METASTATIC ESTROGEN RECEPTOR POSITIVE (ER+), HER2 NEGATIVE, BREAST CANCER PATIENTS. HOWEVER, THE VALUE OF THIS COMBINATION IN POTENTIALLY CURABLE EARLIER STAGE PATIENTS IS VARIABLE. OUR PRELIMINARY RESULTS EXAMINED THE EVOLUTIONARY TRAJECTORIES OF EARLY STAGE BREAST CANCER TUMORS USING SINGLE CELL TRANSCRIPTOMIC PROFILING OF SERIAL TUMOR BIOPSIES FROM A CLINICAL TRIAL OF PREOPERATIVE ENDOCRINE THERAPY ALONE (LETROZOLE) OR IN COMBINATION WITH THE CELL CYCLE INHIBITOR RIBOCICLIB. RESISTANT TUMORS WITH ACCELERATED LOSS OF ESTROGEN SIGNALING SHOW UP-REGULATION OF THE JNK PATHWAY, WHILE THOSE THAT MAINTAIN ESTROGEN SIGNALING DURING THERAPY SHOW POTENTIATION OF CDK4/6 ACTIVATION CONSISTENT WITH ERBB4 AND ERK SIGNALING UP-REGULATION. CELL CYCLE RECONSTRUCTION IDENTIFIED THAT TUMORS CELLS CAN REACTIVATE DURING COMBINATION TREATMENT, INDICATING STRONGER SELECTION FOR A PROLIFERATIVE STATE. WE HYPOTHESIZE THAT RESISTANCE TO CDK4/6 INHIBITION IN EARLIER STAGE BREAST CANCER IS DRIVEN BY JNK MAPK PATHWAY STIMULATION AND REACTIVATION OF THE CELL CYCLE THROUGH PROMOTION OF CDK6 EXPRESSION OR DECREASED CELL CYCLE INHIBITOR FUNCTION. IN AIM 1, WE WILL USE A NEW MECHANISTIC MODEL OF CDK4/6 REGULATION BY CELL CYCLE INHIBITORS AND PROMOTERS (CIP) THAT COUPLES ESTROGEN AND JNK SIGNALING WITH CELL CYCLE PROGRESSION TO MEASURE THE MECHANISMS DRIVING CELL CYCLE ACTIVATION IN A SERIES OF ISOGENIC CELL LINES SENSITIVE AND RESISTANT TO CDK4/6 AND ENDOCRINE INHIBITORS AND IN PATIENT TUMOR CELLS. THIS ANALYSIS WILL REVEAL HOW DISTINCT SIGNALING PATHWAYS CONTRIBUTE TO CELL CYCLE REACTIVATION DURING ESTROGEN, CDK4/6 AND JNK INHIBITION TREATMENTS AND PROVIDE SIGNATURES OF EACH RESISTANT MECHANISM ACROSS CELL TYPES, OVER TIME AND BETWEEN SYSTEMS. AIM 2 LEVERAGES OUR COLLECTION OF PATIENT TUMORS FROM THE FELINE CLINICAL TRIAL TO DISCOVER THE INTRACELLULAR AND INTRATUMORAL RESISTANCE MECHANISMS DRIVING PROLIFERATION. FUNDAMENTAL RESISTANCE MECHANISMS WILL BE MEASURED IN OVER ~300,000 PATIENT CELLS FROM 360 TUMOR SAMPLES USING SINGLE CELL RNA SEQUENCING DATA ALREADY IN HAND TO IDENTIFY CORE INTRACELLULAR SIGNALING STATES THAT ACT ALONE OR IN CONCERT TO DRIVE PROLIFERATION. NEXT, THE POPULATION OF CELLS WITHIN EACH TUMOR WILL BE ANALYZED TO QUANTIFY INTRATUMORAL HETEROGENEITY AND HOW RESISTANT POPULATIONS DIFFER IN GROWING OR SHRINKING TUMORS DURING DRUG TREATMENT. APPLYING CIP TO PROJECT PROLIFERATION ACROSS PATIENT TUMOR CELLS WILL ALLOW PREDICTION OF INHIBITOR STRATEGIES THAT MOST EFFECTIVELY BLOCK INTRACELLULAR AND INTRATUMORAL PROLIFERATION. LASTLY, AIM 3 WILL APPLY A SERIES OF JNK PATHWAY DRUGS WITH CLINICAL POTENTIAL TO DESIGN AND TEST TREATMENT STRATEGIES THAT MAINTAIN DURABLE INHIBITION OF PROLIFERATION IN ER+ CANCER CELLS. ITERATIVE FEEDBACK BETWEEN MATHEMATICAL MODELS AND PATIENT/EXPERIMENTAL DATA SERVES TO PROVIDE A DEEP UNDERSTANDING OF CELL CYCLE REGULATION AND MECHANISMS OF DYSREGULATION LEADING TO RESISTANCE. TOGETHER, THESE EXPERIMENTS WILL REVEAL THE BALANCE BETWEEN ESTROGEN AND ALTERNATIVE MEDIATED JNK SIGNALING, AND THEIR ROLES IN RESISTANCE AND PROVIDE A GUIDE FOR THERAPEUTIC REGIMES WITH MORE DURABLE CONTROL OF CANCER CELL PROLIFERATION.

INFORMATION FLOW AND STATE TRANSITIONS AT THE SYSTEM AND MULTI-DIMENSIONAL SCALES IN LEUKEMIA PROGRESSION

RISK FACTORS FOR MOLECULAR SUBTYPES OF NHL A PROSPECTIVE EVALUATION

CMVPEPVAX TO PROTECT HCT RECIPIENTS FROM CYTOMEGALOVIRUS INFECTION

DIAGNOSTIC ASSAY SYSTEMS FOR BOTULINUM NEUROTOXINS

ENHANCING THE INTRACELLULAR FUNCTIONING OF ANTI-HIV RNAS

CARDIOVASCULAR RESERVE CAPACITY IN SURVIVORS OF HEMATOPOIETIC CELL TRANSPLANTATION

EXERCISE AS INTERCEPTION THERAPY IN PRIMARY HIGH RISK CANCER

THE SSVF PROGRAM'S PURPOSE IS TO PROVIDE SUPPORTIVE SERVICES GRANTS TO PRIVATE NON-PROFIT ORGANIZATIONS AND CONSUMER COOPERATIVES, WHO WILL COORDINATE OR PROVIDE SUPPORTIVE SERVICES TO VERY LOW-INCOME VETERAN FAMILIES WHO ARE RESIDING IN PERMANENT HOUSING, ARE HOMELESS AND SCHEDULED TO BECOME RESIDENTS OF PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD; OR AFTER EXITING PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD, ARE SEEKING OTHER HOUSING THAT IS RESPONSIVE TO SUCH VERY LOW-INCOME VETERAN FAMILY'S NEEDS AND PREFERENCES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES.

MOLECULAR MECHANISMS OF BRCA1-DEPENDENT DNA DAMAGE RESPONSE AND TUMORIGENESIS

HOMELESS PREVENTION

DNA REPAIR GENE MUTATIONS AND PROSTATE CANCER

THE SSVF PROGRAM'S PURPOSE IS TO PROVIDE SUPPORTIVE SERVICES GRANTS TO PRIVATE NON-PROFIT ORGANIZATIONS AND CONSUMER COOPERATIVES, WHO WILL COORDINATE OR PROVIDE SUPPORTIVE SERVICES TO VERY LOW-INCOME VETERAN FAMILIES WHO ARE RESIDING IN PERMANENT HOUSING, ARE HOMELESS AND SCHEDULED TO BECOME RESIDENTS OF PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD; OR AFTER EXITING PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD, ARE SEEKING OTHER HOUSING THAT IS RESPONSIVE TO SUCH VERY LOW-INCOME VETERAN FAMILY'S NEEDS AND PREFERENCES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES.

THE SSVF PROGRAM'S PURPOSE IS TO PROVIDE SUPPORTIVE SERVICES GRANTS TO PRIVATE NON-PROFIT ORGANIZATIONS AND CONSUMER COOPERATIVES, WHO WILL COORDINATE OR PROVIDE SUPPORTIVE SERVICES TO VERY LOW-INCOME VETERAN FAMILIES WHO ARE RESIDING IN PERMANENT HOUSING, ARE HOMELESS AND SCHEDULED TO BECOME RESIDENTS OF PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD; OR AFTER EXITING PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD, ARE SEEKING OTHER HOUSING THAT IS RESPONSIVE TO SUCH VERY LOW-INCOME VETERAN FAMILY'S NEEDS AND PREFERENCES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES.

THE SSVF PROGRAM'S PURPOSE IS TO PROVIDE SUPPORTIVE SERVICES GRANTS TO PRIVATE NON-PROFIT ORGANIZATIONS AND CONSUMER COOPERATIVES, WHO WILL COORDINATE OR PROVIDE SUPPORTIVE SERVICES TO VERY LOW-INCOME VETERAN FAMILIES WHO ARE RESIDING IN PERMANENT HOUSING, ARE HOMELESS AND SCHEDULED TO BECOME RESIDENTS OF PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD; OR AFTER EXITING PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD, ARE SEEKING OTHER HOUSING THAT IS RESPONSIVE TO SUCH VERY LOW-INCOME VETERAN FAMILY'S NEEDS AND PREFERENCES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES.

TARGETING P38 GAMMA SIGNALING TO ADVANCE CUTANEOUS T CELL LYMPHOMA THERAPY