Vela

THE 100% HYDROGEN-READY FLEX-FUEL DIRECT REDUCED IRONMAKING AND ELECTRIC MELTING FURNACE RETROFIT AT CLEVELAND-CLIFFS INTEGRATED IRON AND STEEL FACILITY PROJECT, LED BY CLEVELAND-CLIFFS STEEL CORPORATION (CLIFFS), PLANS TO DEMONSTRATE SUCCESSFUL RETROFIT OF THEIR MIDDLETOWN WORKS FACILITY IN OHIO BY REPLACING THE EXISTING BLAST FURNACE WITH A 100% HYDROGEN-READY, FLEX-FUEL, DIRECT REDUCED IRON (DRI) AND TWO ELECTRIC MELTING FURNACES (EMF). THIS PROJECT WILL DEMONSTRATE A FEASIBLE PATHWAY TO SIGNIFICANTLY REDUCE GREENHOUSE GAS (GHG) AND CRITERIA AIR POLLUTANT (CAP) EMISSIONS WHILE SERVING AS A BLUEPRINT FOR GLOBALLY INTEGRATED STEELMAKERS. THIS PROJECT WILL ENGAGE WITH THE LOCAL COMMUNITY AND WORKERS VIA TWO-WAY ENGAGEMENT, IMPROVE AIR QUALITY FOR LOCAL COMMUNITIES, AND SUSTAIN QUALITY UNION JOBS.

HEAD START: FULL YEAR PART DAY HANDICAPPED T/TAFULL YEAR FULL DAY

APPLICATION PURPOSE: GCRTA WILL REPLACE ITS EXISTING RAIL FLEET WHICH HAS REACHED THE END OF ITS USEFUL LIFE WITH NEW RAIL VEHICLES.; ACTIVITIES PERFORMED: PROCURE AND REPLACE EXISTING RAIL VEHICLES.; EXPECTED OUTCOMES: IMPROVED RELIABILITY OF GCRTAS RAIL SYSTEM.; INTENDED BENEFICIARIES: RESIDENTS OF CUYAHOGA COUNTY; SUBRECIPIENT ACTIVITIES: N/A

THIS GRANT PROVIDES A TOTAL OF $136108510.00 IN AMERICAN RESCUE PLAN (ARP) OPERATING ASSISTANCE TO THE GREATER CLEVELAND REGIONAL TRANSIT AUTHORITY (GCRTA) FOR THE PERIOD OF JANUARY 20 2021 THROUGH DECEMBER 31 2024. THERE IS NO LOCAL SHARE AS FUNDING WILL BE 100% THROUGH FTA. ATTACHMENTS INCLUDE THE GCRTA LETTER DATED MAY 24 2021 LISTING THE APPORTIONMENTS FOR EACH TRANSIT AGENCY WITHIN THE CLEVELAND AND AKRON URBANIZED AREAS.THE RECIPIENT AGREES THAT IF IT RECEIVES FEDERAL FUNDING FROM THE FEDERAL EMERGENCY MANAGEMENT AGENCY (FEMA) OR THROUGH A PASS-THROUGH ENTITY THROUGH THE ROBERT T. STAFFORD DISASTER RELIEF AND EMERGENCY ASSISTANCE ACT A DIFFERENT FEDERAL AGENCY OR INSURANCE PROCEEDS FOR ANY PORTION OF A PROJECT ACTIVITY APPROVED FOR FTA FUNDING UNDER THIS GRANT AGREEMENT IT WILL PROVIDE WRITTEN NOTIFICATION TO FTA AND REIMBURSE FTA FOR ANY FEDERAL SHARE THAT DUPLICATES FUNDING PROVIDED BY FEMA ANOTHER FEDERAL AGENCY OR AN INSURANCE COMPANY.DUE TO THE COVID-19 PANDEMIC GCRTA HAS AN ON-GOING NEED FOR EMERGENCY OPERATING ASSISTANCE. THEREFORE THE PERIOD OF PERFORMANCE DATES FOR GCRTAS CORONAVIRUS RESPONSE AND RELIEF SUPPLEMENTAL APPROPRIATION ACT (CRRSA) FAIN #OH-2021-011-00 OVERLAP WITH THE PERIOD OF PERFORMANCE FOR ARPA FUNDING AS A PRECAUTION IN CASE THE FUNDING FROM CRRSA ARE INSUFFICIENT TO MEET OUR NEEDS.

APPLICATION PURPOSE: FUNDS WILL SUPPORT THE PURCHASE OF NEW VEHICLES AND MAINTAIN A STATE OF GOOD REPAIR FOR FACILITIES AND PROPERTIES OWNED AND OPERATED BY GCRTA.; ACTIVITIES PERFORMED: PURCHASE OF NEW BUSES AND SPARE PARTS PURCHASE OF NEW RAIL CARS AND SPARE PARTS BUS RAIL PM ACTIVITIES ON-CALL ENGINEERING SERVICES RAIL TRACK REHABILITATION AND SIGNAL UPGRADES PAVEMENT HVAC AND ROOFING IMPROVEMENT PROGRAMS TRACK AND BRIDGE CONSTRUCTION OVERHEAD CATENARY CONSTRUCTION SUBSTATION IMPROVEMENTS IT UPGRADES AND ELECTRONIC RECORD PROGRAMS ENHANCED ADA RAIL ACCESS FARE COLLECTION SYSTEM ELEVATOR REPLACEMENT CREATION OF TRAINING SPACE AND THE METROHEALTH BRT LINE.; EXPECTED OUTCOMES: FACILITY AND TRACK UPGRADES VEHICLE UPGRADES AND IMPROVED TRANSIT OPERATIONS THROUGHOUT CUYAHOGA COUNTY.; INTENDED BENEFICIARIES: RESIDENTS OF CUYAHOGA COUNTY UTILIZING TRANSIT.; SUBRECIPIENT ACTIVITIES: N/A

SECTION 5307 FY2020 CORONAVIRUS AID RELIEF AND ECONOMIC SECURITY (CARES) ACT OPERATING ASSISTANCE GRANT

RECOVERY ACT: ARCELORMITTAL USA BLAST FURNACE GAS FLARE CAPTURE

DESCRIPTION:THE PURPOSE OF THIS AWARD IS TO PROVIDE FUNDING UNDER THE INFLATION REDUCTION ACT TO CLEVELAND-CUYAHOGA COUNTY PORT AUTHORITY. SPECIFICALLY, THE RECIPIENT WILL IMPROVE AIR QUALITY AND REDUCE POLLUTION AT THE PORT OF CLEVELAND AND IN THE SURROUNDING AREA THROUGH THE DEPLOYMENT OF ZERO-EMISSION EQUIPMENT AND INFRASTRUCTURE AT THE PORT.ACTIVITIES:THE ACTIVITIES INCLUDE THE DEPLOYMENT OF 10 NEW FORKLIFTS, 2 REACH STACKERS, 7 180-KW VEHICLE CHARGERS, 2 ELECTRIC TUGBOATS, 2 DIESEL TUGBOATS, 2 HARBOR VESSEL CHARGING SYSTEMS, AND 1 MOBILE HARBOR CRANE. OTHER DELIVERABLES INCLUDE THE INSTALLATION OF ONE CRANE CHARGING AND POWERING EQUIPMENT, INSTALLATION OF VESSEL SHORE POWER AT ONE DOCK LOCATION, INSTALLATION OF INFRASTRUCTURE TO EXPAND FUTURE VESSEL SHORE POWER OPERATIONS, AND INSTALLATION OF ONE SOLAR ENERGY SYSTEM AND ASSOCIATED BATTERY ENERGY STORAGE SYSTEM.SUBRECIPIENT:TO ENHANCE PROJECT EFFECTIVENESS AND EFFICIENCY, THE PORT WILL EXECUTE SUBAWARD AGREEMENTS, CONSISTENT WITH THIS GRANT APPLICATION AND EPA'S SUBAWARD POLICY, WITH BOTH LOGISTEC AND GLT. LOGISTEC AND GLT WILL RETAIN OWNERSHIP OF ALL NEWLY PURCHASED EQUIPMENT AND INFRASTRUCTURE AND WILL BE FULLY RESPONSIBLE FOR ALL FUTURE OPERATIONAL AND MAINTENANCE NEEDS. ALL PURCHASES WILL REMAIN IN CLEVELAND TO SERVE THE PORT IN ACCORDANCE WITH NOFO REQUIREMENTS. OUTCOMES:THE ANTICIPATED ACTIVITIES INCLUDE A FLEET OF ZERO-EMISSION VEHICLES AND ASSOCIATED CHARGING EQUIPMENT. THE EXPECTED OUTCOMES INCLUDE REDUCED NITROGEN OXIDES, FINE PARTICULATE MATTER, AND CARBON DIOXIDE EMISSIONS; INCREASED RENEWABLE POWER OUTPUT; REDUCED RELIANCE ON DIESEL FUELS; REDUCED POWER GRID EMISSIONS; INCREASED TRANSPARENCY AND COMMUNICATION ABOUT PORT ACTIVITIES WITH THE LOCAL COMMUNITY; AND INCREASED ACCESS TO HIGH-QUALITY JOB OPPORTUNITIES FOR NEAR-PORT COMMUNITIES. THE INTENDED BENEFICIARIES INCLUDE THE PORT OF CLEVELAND, LOGISTEC, AND GREAT LAKES TOWING, WHICH WILL CONTINUE TO SUPPORT DAILY OPERATIONS AND FACILITATE CARGO MOVEMENT AT THE PORT, AS WELL AS MANAGE OPERATIONAL AND MAINTENANCE NEEDS FOR ALL NEWLY PURCHASED EQUIPMENT AND INFRASTRUCTURE. INDIRECT BENEFICIARIES INCLUDE NEAR-PORT COMMUNITIES WHICH WILL EXPERIENCE IMPROVED AMBIENT AIR QUALITY.

APPLICATION PURPOSE: PURCHASE REPLACEMENT CNG-FUELED VEHICLES REPLACEMENT RAIL VEHICLES REPLACEMENT SHELTERS AND AMENITIES ALONG THE SHAKER RAPID LINE LIGHT RAIL TRACK RECONSTRUCTION AND ELECTRIC VEHICLE (EV) PLANNING STUDY.; ACTIVITIES PERFORMED: REPLACE EXISTING DIESEL-FUELED VEHICLES WHICH HAVE REACHED THE END OF THEIR USEFUL LIVES WITH CNG-FUELED VEHICLES REPLACE RAIL VEHICLES WHICH HAVE REACHED THE END OF THEIR LIVES WITH NEW VEHICLES REPLACE EXISTING LIGHT RAIL TRACK WITH NEW TRACK REPLACE SHELTERS ALONG THE SHAKER RAPID LINE WHICH HAVE REACHED THE END OF THEIR USEFUL LIVES AND IMPLEMENT AN ELECTRIC VEHICLE PLANNING (EV) STUDY.; EXPECTED OUTCOMES: CNG-FUELED VEHICLES WILL INCREASE AIR QUALITY AND RELIABILITY OF THE TRANSIT SYSTEM. REPLACEMENT RAIL VEHICLES AND LIGHT RAIL (LR) TRACK REPAIR WILL INCREASE SYSTEM RELIABILITY. REPLACEMENT SHELTERS WILL PROVIDE PROTECTION FOR CUSTOMERS DURING INCLEMENT WEATHER. ELECTRIC VEHICLE (EV) PLANNING WILL DETERMINE THE BEST APPROACH FOR INTEGRATION OF FUTURE ELECTRIC VEHICLES IN GCRTAS BUS FLEET.; INTENDED BENEFICIARIES: GCRTAS CUSTOMERS AND THE RESIDENTS OF CUYAHOGA COUNTY.; SUBRECIPIENT ACTIVITIES: N/A

THE STEEL SLAB ELECTRIFIED INDUCTION REHEAT FURNACE UPGRADE TO REDUCE GHG EMISSIONS AND ENHANCE QUALITY, LED BY CLEVELAND-CLIFFS STEEL CORPORATION (CLIFFS), PLANS TO CONSTRUCT FOUR NEW INDUCTION REHEAT FURNACES (IRF) FOR THE HIGH TEMPERATURE PRODUCTION OF HIGH-SILICON GRAIN ORIENTED ELECTRICAL STEEL (GOES), WHICH IS USED TO MANUFACTURE ELECTRICAL TRANSFORMERS. THIS TECHNOLOGY CAN BE REPLICABLE ACROSS THE INDUSTRY TO ELECTRIFY THE STEEL SLAB REHEATING PROCESS. IDLE TWO EXISTING HIGH TEMPERATURE NATURAL GAS FIRED REHEAT FURNACES UPON SUCCESSFUL COMMISSIONING OF IRFS. THIS PROJECT WILL ENGAGE WITH LOCAL COMMUNITY AND WORKERS VIA TWO-WAY ENGAGEMENT, IMPROVE AIR QUALITY FOR LOCAL COMMUNITIES, AND SUSTAIN QUALITY UNION JOBS.

GCRTA CRRSAA SECTION 5307 OPERATING ASSISTANCE

COVID-19 DPA3 MAINTAIN, MODERNIZE, AND EXPAND CAPABILITIES FOR NAVY GRADE ALLOY STEEL PLATE

COMMUNITY DEVELOPMENT BLOCK GRANTS/ENTITLEMENT GRANTS

SECS. 5307 5337 5339 AND STBG BUS RAIL PREVENTIVE MAINTENANCE BUS RAIL ACTIVITIES BUS AND RAIL CAR REPLACEMENT

APPLICATION PURPOSE: FUNDS WILL SUPPORT THE PURCHASE OF NEW VEHICLES AND MAINTAIN A STATE OF GOOD REPAIR FOR FACILITIES AND PROPERTIES OWNED AND OPERATED BY GCRTA.; ACTIVITIES PERFORMED: PURCHASE OF NEW BUSES AND SPARE PARTS PURCHASE OF NEW RAIL CARS AND SPARE PARTS BUS RAIL PM ACTIVITIES ON-CALL ENGINEERING SERVICES RAIL TRACK REHABILITATION AND SIGNAL UPGRADES PAVEMENT HVAC AND ROOFING IMPROVEMENT PROGRAMS TRACK AND BRIDGE CONSTRUCTION OVERHEAD CATENARY CONSTRUCTION SUBSTATION IMPROVEMENTS IT UPGRADES AND ELECTRONIC RECORD PROGRAMS ENHANCED ADA RAIL ACCESS AND FARE COLLECTION SYSTEM.; EXPECTED OUTCOMES: FACILITY AND TRACK UPGRADES VEHICLE UPGRADES AND IMPROVED TRANSIT OPERATIONS THROUGHOUT CUYAHOGA COUNTY.; INTENDED BENEFICIARIES: RESIDENTS OF CUYAHOGA COUNTY PARTICULARLY THOSE UTILIZING TRANSIT.; SUBRECIPIENT ACTIVITIES: N/A

APPLICATION PURPOSE: FUNDS WILL SUPPORT THE PURCHASE OF NEW VEHICLES AND MAINTAIN A STATE OF GOOD REPAIR FOR FACILITIES AND PROPERTIES OWNED AND OPERATED BY GCRTA.; ACTIVITIES PERFORMED: PURCHASE NEW BUSES AND SPARE PARTS PURCHASE NEW RAIL CARS LIGHT RAIL TRACK REHABILITATION PAVEMENT PROGRAM ROOF REPLACEMENTS TRACK AND BRIDGE CONSTRUCTION OVERHEAD CATENARY CONSTRUCTION HVAC IMPROVEMENT BUS WASHING AND LIFT REPLACEMENT RAIL STATION ADA CONSTRUCTION/COMPLIANCE AND FARE COLLECTION EQUIPMENT.; EXPECTED OUTCOMES: FACILITY UPGRADES AND IMPROVED TRANSIT OPERATIONS THROUGHOUT THE COUNTY; INTENDED BENEFICIARIES: RESIDENTS OF CUYAHOGA COUNTY UTILIZING TRANSIT.; SUBRECIPIENT ACTIVITIES: N/A

REGIONAL PEDIATRIC PANDEMIC NETWORK

SECS. 5307 5337 AND 5339 BUS AND RAIL PREVENTIVE MAINTENANCE BUS AND RAIL ACTIVITIES AND BUS REPLACEMENT

IMPROVE EXISTING AIRPORT

2016 PRESIDENTIAL CANDIDATE NOMINATING CONVENTION - REPUBLICAN NATIONAL CONVENTION - CLEVELAND

CHILDREN'S HOSPITALS GRADUATE MEDICAL EDUCATION PAYMENT PROGRAM

MODERNIZATION OF NAVY-GRADE ALLOY STEEL PLATE PROJECT ** FAADC MIGRATION NOTE - ACTION TYPE:"1" TO "A", ASSISTANCE TYPE:"5" TO "05", RECORD TYPE:"2", BUSINESS FUNDS INDICATOR:"NON", INDIVIDUAL RECIPIENT INDICATOR:"NO", RESEARCH AND DEVELOPMENT FUNDS INDICATOR:"YES", COMPETED OPPORTUNITY:"1" TO "C", NUMBER OF PROPOSALS OR APPLICATIONS:"1", AWARDING SUB-TIER AGENCY CODE "5700" DERIVED FROM AWARDING OFFICE CODE "FA8650", FUNDING SUB-TIER AGENCY CODE "5700" DERIVED FROM FUNDING OFFICE CODE "F4FBCN", PPOP COUNTRY CODE:"USA", SMALL BUSINESS INDICATOR:"O", SAM EXCEPTION:"X" **

ORIGINAL GRANT- GCRTA IS APPLYING FOR FTA FUNDING ASSISTANCE IN THE AMOUNT OF $32307626 BROKEN DOWN AS FOLLOWS: A-GCRTA IS APPLYING FOR $17467760 IN SECTION 5307 FUNDING. THE 5307 FUNDS ARE COMPRISED FROM THE FOLLOWING SOURCES: $216713 IN FY20 CLEVELAND UZA 5307 FUNDS TRANSFERRED FROM MEDINA COUNTY PUBLIC TRANSIT $291047 IN FY21 CLEVELAND UZA 5307 FUNDS TRANSFERRED FROM MEDINA COUNTY PUBLIC TRANSIT $6771355 IN FY20 CLEVELAND UZA 5307 FUNDS $10188645 IN FY21 CLEVELAND UZA 5307 FUNDS B-GCRTA IS APPLYING FOR $12494000 IN SECTION 5337 FUNDING. THE 5337 FUNDS ARE COMPRISED FROM THE FOLLOWING SOURCES: $180241 IN FY18 MOTORBUS FUNDS $117232 IN FY20 FIXED GUIDEWAY RAIL FUNDS $12196527 IN FY21 FIXED GUIDEWAY RAIL FUNDS C-GCRTA IS APPLYING FOR$2345866 IN SECTION 5339 FUNDING. THE 5339 FUNDS ARE COMPRISED FROM THE FOLLOWING SOURCES:$92240 IN FY20 FUNDS TRANSFERRED FROM MEDINA COUNTY PUBLIC TRANSIT$458274 IN FY20 CLEVELAND UZA 5339 FUNDS$1795352 IN FY21 CLEVELAND UZA 5339 FUNDSLOCAL SHARE IN THE AMOUNT OF $8076906 WILL BE PROVIDED THROUGH THE BOND PROCEEDS AND SALES TAX REVENUE.SEC5307 FUNDS WILL SUPPORT THE FOLLOWING PROGRAMS : BUS VEHICLES REPLACEMENT AND SPARE PARTS LIGHT RAIL TRACK REHABILITATION RAIL STATE OF GOOD REPAIR PROJECTS BUS PREVENTIVE MAINTENANCE ADA ENHANCED RAIL ACCESS NOACA UNSERVED AREA PROJECTS PAVEMENT IMPROVEMENTS ROOF REPLACEMENTS TRACK BRIDGE REHABILITATION OVER BROOKPARK CONRAIL AND THE WATERFRONT LINE RAIL CAR VEHICLES REPLACEMENT HVAC SYSTEM IMPROVEMENT AND IT UPGRADE.MEDINA TRANSFERS FOR SEC5307 WILL BE ADDED TO PREVENTIVE MAINTENANCE. PER AN INTERNAL AGREEMENT GCRTA WILL APPLY FOR THE FUNDS FOR MEDINA AND DISBURSE LOCAL FUNDS TO MEDINA IN EXCHANGE. THE AGREEMENT HAS FTA APPROVAL.SEC5337 FUNDS WILL SUPPORT THE FOLLOWING PROGRAMS : SUBSTATION IMPROVEMENT LIGHT RAIL TRACK REHABILITATION RAIL STATE OF GOOD REPAIR RAIL PREVENTIVE MAINTENANCE INFRASTRUCTURE AND SPARE PARTS PROGRAMS ON-CALL RAIL ENGINEERING SERVICES OVERHEAD CATENARY SYSTEM REHABILITATION AND SIGNAL SYSTEM UPGRADE.SEC5339 FUNDS WILL SUPPORT BUS REPLACEMENT PROGRAM AND SPARE PARTS.MEDINA TRANSFERS FOR SEC5339 WILL BE ADDED TO BUS REPLACEMENT PROGRAM. PER AN INTERNAL AGREEMENT GCRTA WILL APPLY FOR THE FUNDS FOR MEDINA AND DISBURSE LOCAL FUNDS TO MEDINA IN EXCHANGE. THE AGREEMENT HAS FTA APPROVAL.AUTHORIZATION TO SUBMIT THIS GRANT IS CONTAINED IN GCRTA BOARD OF TRUSTEES RESOLUTION 2007-165 APPROVED IN DECEMBER 2007.ATTACHMENTS INCLUDE CUZA ALLOCATION TABLE DATED FEBRUARY 25 2021; PAGES 1981 TO 1998 ODOT STIP 2021-2024 TRANSIT PROJECT LIST REVISIONS AS OF 3/19/2021; GCRTA BUS IMPROVEMENT LIST 2021-Q1; GCRTA BUS REPLACEMENT LIST; PAGE 197 NOACA SFY2021-2024 TRANSPORTATION IMPROVEMENT PROGRAM TRANSIT PROJECTS; AND FTA APPROVAL LETTER EFFECTIVE 7/1/2020.IN EXECUTING THIS GRANT GCRTA AGREES TO ABIDE BY SECTION 3011 OF THE FAST ACT (49 U.S.C. 5323 (J)(2)( C) REGARDING THE PHASED INCREASE IN DOMESTIC CONTENT UNDER THE BUY AMERICA STATUE FOR ROLLING STOCK.AS GRANT AGREEMENT INCLUDES AN FTA-FUNDED TRANSIT VEHICLE PURCHASE GCRTA AGREES TO COMPLY WITH THE RELATED REQUIREMENTS SET FORTH IN 49 CFR SEC 26.49(A). SPECIFICALLY GCRTA MUST ENSURE AS A CONDITION OF BEING AUTHORIZED TO BID OR PROPOSE ON FTA-ASSISTED TRANSIT VEHICLE PROCUREMENTS THAT EACH TRANSIT VEHICLE MANUFACTURER CERTIFIED THAT IT COMPLIED WITH DOT REQUIREMENTS FOR SUBMITTING A DBE PROGRAM AND GOAL TO FTA PRIOR TO BIDDING. GCRTA IS ALSO REQUIRED TO SUBMIT THE NAME OF THE SUCCESSFUL BIDDER AND THE TOTAL DOLLAR VALUE OF THE CONTRACT WITHIN 30 DAYS OF MAKING A FTA-ASSISTED TRANSIT VEHICLE AWARD USING THE REQUIRED FTA REPORTING TOOL. GCRTA UNDERSTANDS THAT FAILURE TO COMPLY WITH THESE REQUIREMENTS MAY RESULT IN FORMAL ENFORCEMENT ACTION OR APPROPRIATE SANCTION AS DETERMINED BY FTA INCLUDING REIMBURSEMENT OF FTA FUNDS USED FOR THE VEHICLE PROCUREMENT.

CLEVELAND STATE UNIVERSITY HIGHER EDUCATION EMERGENCY RELIEF FUND-IHE/INSTITUTION

OPERATING ASSISTANCE AND TRACK REHA

PURPOSE: AMERICAN RESCUE PLAN ACT AWARDED AS ECONOMIC ASSISTANCE TO ELIGIBLE U.S. AIRPORTS AND ELIGIBLE CONCESSIONS AT THOSE AIRPORTS TO PREVENT, PREPARE FOR, AND RESPOND TO THE COVID-19 PANDEMIC. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS GRANT PROVIDES ECONOMIC RELIEF FUNDS FOR COSTS RELATED TO OPERATIONS, PERSONNEL, CLEANING, SANITIZATION, JANITORIAL SERVICES, DEBT SERVICE PAYMENTS, AND COMBATING THE SPREAD OF PATHOGENS AT THE AIRPORT. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH CLEVELAND, OHIO.

CSU EMERGENCY FINANCIAL AID GRANTS TO STUDENTS UNDER CORONAVIRUS AID, RELIEF AND ECONOMIC SECURITY ACT

IMPROVE EXISTING AIRPORT

FFY 2009 5307 UZA FORMULA FUNDS

AWARD PURPOSE THE PROJECT CONSISTS OF BOTH DEVELOPMENT PHASE PLANNING PERMITTING ENGINEERING AND DESIGN AND CONSTRUCTION ACTIVITIES AT THE PORT OF CLEVELAND. IT WILL MODERNIZE A 144000 SQUARE FOOT WAREHOUSE WAREHOUSE A EXPAND STORMWATER COLLECTION AND TREATMENT INFRASTRUCTURE CONSTRUCT A MODERNIZED MAINTENANCE AND REPOWERING FACILITY FOR TERMINAL EQUIPMENT AND INSTALL ELECTRIC INFRASTRUCTURE TO MEET THE POWER REQUIREMENTS OF SHIP COLD IRONING AND ELECTRIFIED CARGO HANDLING EQUIPMENT. ACTIVITIES TO BE PERFORMED THE PROJECT WILL CONSIST OF BOTH A DEVELOPMENT PHASE WHICH INCLUDES PLANNING PERMITTING ENGINEERING AND DESIGN AND A CONSTRUCTION PHASE THAT WILL FUND IMPROVEMENTS TO W 3RD LOT CARGO WAREHOUSE A REHABILITATION AND MODERNIZATION AND ELECTRIFICATION AND STORMWATER ENHANCEMENTS. THE PROJECT WILL INCLUDE THE FOLLOWING COMPONENTS COMPONENT 1 DESIGNENGINEERING COMPONENT 1A THIS SCOPE WHICH WAS AUTHORIZED TO BEGIN PREAWARD AS OUTLINED IN THIS AGREEMENT IN SECTION 5 OF SCHEDULE D WILL FOCUS ON SURVEYING THE TERMINALS EXISTING UTILITY INFRASTRUCTURE WITH SPECIFIC ATTENTION PAID TO THE ELECTRICAL INFRASTRUCTURE. THE RECIPIENT WILL DEVELOP A FUTURE ELECTRICAL NEEDS DEMAND ASSESSMENT AND A TERMINAL ELECTRIFICATION AND NET ZERO EMISSION MASTER PLAN INCLUSIVE OF A SOLAR FEASIBILITY STUDY TO ASSESS THE POTENTIAL OF DEPLOYING A SOLAR ARRAY TO THE ROOF OF WAREHOUSE A TO SUPPORT THE RECIPIENTS NET ZERO EMISSION GOALS AT THIS MARINE TERMINAL. FINALLY IN COORDINATION WITH A LOCAL ELECTRIC UTILITY PROVIDER CLEVELAND PUBLIC POWER THE RECIPIENT WILL REVIEW EXISTING INFRASTRUCTURE AND FUTURE NEEDS TO DETERMINE ADDITIONAL SERVICE REQUIRED AND DEFINE THE ELECTRICAL SERVICE UPGRADES WITHIN AND OUTSIDE OF THE TERMINAL. THE RECIPIENT WILL USE THE INFORMATION COLLECTED UNDER THIS COMPONENT TO DEVELOP A DETAILED BASIS OF DESIGN FOR THE PROJECT. COMPONENT 1B THIS SCOPE OF SERVICES WILL TAKE THE BASIS OF DESIGN INFORMATION COLLECTED IN COMPONENT 1A AND PREPARE THE PLANS SPECIFICATIONS UPDATE ENGINEERS ESTIMATES AND ADVANCE THE LOCAL PERMITTING REQUIRED TO ADVANCE COMPONENTS 2 AND 3. COMPONENT 2 CONSTRUCTION COMPONENT 2A ON-TERMINAL ELECTRIFICATION AND WAREHOUSE A MODERNIZATION CONSTRUCTION W. 3RD LOT CARGO MOVEMENT EFFICIENCY IMPROVEMENTS DEMOLISH EXISTING CARGO HANDLING EQUIPMENT MAINTENANCE FACILITY AND HIRING HALL BUILDING AND RECONSTRUCT BOTH AS ANNEXED WINGS OF WAREHOUSE A. WAREHOUSE A REHABILITATION AND MODERNIZATION WAREHOUSE A WILL BE BROUGHT TO A STATE OF GOOD REPAIR WITH IMPROVEMENTS INCLUDING BUT NOT LIMITED TO STRUCTURAL STEEL REPAIRS AND COATINGS SECURITY AND COMMUNICATION IMPROVEMENTS OVERHEAD DOOR CONSOLIDATION AND REPLACEMENT WINDOW REPLACEMENT RESTROOM FACILITY UPGRADES AND ENHANCEMENTS LED LIGHTING CONVERSION CONCRETE SLAB AND SILL REPLACEMENT AND FIRE SUPPRESSION SYSTEM REPLACEMENT. THIS SCOPE WILL ALSO INCLUDE TYING IN EXTERIOR PAVEMENT GRADES WITH INTERIOR ELEVATED GRADES OF WAREHOUSE A. THIS SCOPE WILL REPLACE THE AREAS OF THE ROOF THAT REQUIRE REPLACEMENT AND OR REHABILITATE AND TIE IN NEWER SEGMENTS OF ROOF TO ACHIEVE THE GOAL OF HAVING A COMPLETED ROOF THAT WILL PROVIDE A MINIMUM OF 50 YEARS OF ANTICIPATED SERVICE LIFE. ELECTRIFICATION AND STORMWATER ENHANCEMENTS: INCLUDES ON TERMINAL ELECTRICAL UPGRADES INCLUDING THE TERMINATION OF NEW MEDIUM HIGH VOLTAGE TO WAREHOUSE A TO ESTABLISH THE TERMINALS ELECTRIC DISTRIBUTION HUB AND INFRASTRUCTURE UPGRADES GUIDED BY THE RESULTS OF THE TERMINAL ELECTRIFICATION MASTER PLAN COMPONENT 1A. FROM THE NEWLY ESTABLISHED POWER DISTRIBUTION HUB SUFFICIENT POWER WILL BE RUN TO THE MAINTENANCE FACILITY WING AND THE LOCOMOTIVE STORAGE LOCATION ON SITE. THIS PROJECT WILL ALSO CONSOLIDATE DRAINAGE IN THE PROJECT AREA AND DIRECT IT TO PREVIOUSLY INSTALLED OR NEW STORMWATER TREATMENT INFRASTRUCTURE IN ACCORDANCE WITH THE PORTS STORMWATER MASTER PLAN. COMPONENT 2B OFF TERMINAL ELECTRIFICATION. THE ESTABLISHMENT OF NEW OR THE RECONFIGURATION OF EXISTING MEDIUM SERVICE VOLTAGE COMING INTO THE MARINE TERMINAL FROM EXISTING CLEVELAND PUBLIC POWER INFRASTRUCTURE PRESENTLY LOCATED OUTSIDE OR WITHIN THE LIMITS OF THE MARINE TERMINAL. THIS PHASE OF THE PROJECT WILL BE ADVANCED IN PARTNERSHIP WITH THE LOCAL ELECTRIC UTILITY SERVICE PROVIDER CLEVELAND PUBLIC POWER. COMPONENT 2C WAREHOUSE A AND MAINTENANCE FACILITY CRANE INSTALLATION. REPLACEMENT OF THE OVERHEAD CRANE IN THE CENTRAL BAY OF WAREHOUSE A AND INSTALLATION OF AN OVERHEAD CRANE IN THE NEWLY CONSTRUCTED MAINTENANCE FACILITY. COMPONENT 3 FIELD INSPECTION CONSTRUCTION OVERSIGHT AND COMPLIANCE SUPPORT SERVICES. THIRD PARTY INSPECTION CONSTRUCTION OVERSIGHT AND COMPLIANCE SUPPORT SERVICES NECESSARY TO ADVANCE COMPONENT 2 SUPPORTING THE RECIPIENTS STAFF IN THE DAY TO DAY MANAGEMENT AND OVERSIGHT OF THE PROJECT. DELIVERABLES EXPECTED OUTCOMES PERFORMANCE MEASURE TABLE FROM SCHEDULE G PAGE 13 OF THE GRANT AGREEMENT. INTENDED BENEFICIARY CLEVELAND CUYAHOGA COUNTY PORT AUTHORITY. SUBRECIPIENT ACTIVITIES NONE.

ASTHMA INFLAMMATION RESEARCH (AIR)

APPLICATION PURPOSE: IMPROVE TRANSIT SERVICE THROUGH THE PURCHASE OF REPLACEMENT BUSES AND CONSTRUCTION PROJECTS.; ACTIVITIES PERFORMED: PURCHASE VEHICLES AND ENHANCE EXISTING INFRASTRUCTURE.; EXPECTED OUTCOMES: IMPROVED TRANSIT SERVICE.; INTENDED BENEFICIARIES: RESIDENTS AND USERS OF TRANSIT WITHIN CUYAHOGA COUNTY.; SUBRECIPIENT ACTIVITIES: N/A

ENTITLED CITIES

FY 2008 CAPITAL FORMULA

APPLICATION PURPOSE: RAIL TRACK REHABILITATION; ACTIVITIES PERFORMED: TRACK REHABILITATION; EXPECTED OUTCOMES: IMPROVED RAIL TRANSIT; INTENDED BENEFICIARIES: GCRTA RAIL RIDERS; SUBRECIPIENT ACTIVITIES: N/A

ENTITLED CITIES

2016 SEC 5307 URBAN

ENTITLED CITIES

PURPOSE: RECONSTRUCT WILDLIFE PERIMETER FENCING. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT RECONSTRUCTS 51,000 FEET OF EXISTING WILDLIFE FENCING AND 8 EXISTING GATES THAT HAVE REACHED THE END OF THEIR USEFUL LIVES. THIS GRANT FUNDS THE FINAL PHASE, WHICH CONSISTS OF CONSTRUCTION. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH CLEVELAND, OHIO.

2014 CAPITAL FORMULA

FY2011 CAPITAL FORMULA

2012 CAPITAL FORMULA

SECTION 5307 BUS ACQUISITIONS PREVENTIVE MAINTENANCE STATION CONSTRUCTION/ENHANCEMENTS

RESEARCH AND DEVELOPMENT OF BETTER DIAGNOSIC TOOLS FOR MENTAL ILLNESS, NEUROLOGICAL DISORDERS, TRAUMATIC BRAIN INJURY AND POST TRAUMATIC STRESS DISOR

2013 CAPITAL FORMULA

COMMUNITY DEVELOPMENT BLOCK GRANTS/ENTITLEMENT GRANTS

ENTITLED CITIES

IFNS AND CYTOKINES: SIGNALING AND ACTION

COMMUNITY DEVELOPMENT BLOCK GRANTS/ENTITLEMENT GRANTS

COMMUNITY DEVELOPMENT BLOCK GRANTS/ENTITLEMENT GRANTS

COMMUNITY DEVELOPMENT BLOCK GRANTS/ENTITLEMENT GRANTS

CLEVELAND HEALTHY FAMILY/ HEALTHY START PROJECT

COBRE GRANT

PURPOSE: THE COMMUNITY DEVELOPMENT BLOCK GRANT (CDBG) PROGRAM PROVIDES ANNUAL GRANTS ON A FORMULA BASIS TO STATES, CITIES, AND COUNTIES TO DEVELOP VIABLE URBAN COMMUNITIES BY PROVIDING DECENT HOUSING AND A SUITABLE LIVING ENVIRONMENT, AND BY EXPANDING ECONOMIC OPPORTUNITIES, PRINCIPALLY FOR LOW- AND MODERATE-INCOME PERSONS. THE PROGRAM IS AUTHORIZED UNDER TITLE 1 OF THE HOUSING AND COMMUNITY DEVELOPMENT ACT OF 1974, PUBLIC LAW 93-383, AS AMENDED 42 U.S.C. 5301 ET SEQ. THE CDBG PROGRAM COVERS FOUR DISTINCT PROGRAMS, EACH WITH THEIR OWN SET OF GOVERNING REGULATIONS: CDBG ENTITLEMENT, CDBG NON-ENTITLED COUNTIES IN HAWAII, CDBG INSULAR AREAS, AND STATE CDBG. IN THE CDBG ENTITLEMENT PROGRAM, HUD AWARDS GRANTS TO ENTITLEMENT COMMUNITY GRANTEES TO CARRY OUT A WIDE RANGE OF COMMUNITY DEVELOPMENT ACTIVITIES. ENTITLEMENT COMMUNITIES DEVELOP THEIR OWN PROGRAMS AND FUNDING PRIORITIES. IN THE CDBG NON-ENTITLED COUNTIES IN HAWAII PROGRAM, THREE COUNTIES QUALIFY: HAWAII, KAUAI, AND MAUI. THE FY 2004 APPROPRIATIONS ACT REQUIRED THE GOVERNOR OF HAWAII TO DECIDE IF THE STATE WISHED TO PARTICIPATE IN THE STATE CDBG PROGRAM BY JULY 31, 2004. THE STATE MADE THE DECISION NOT TO PARTICIPATE IN THE PROGRAM. AS A RESULT OF THIS DECISION HUD'S HONOLULU FIELD OFFICE ADMINISTERS THE NON-ENTITLED GRANTS IN HAWAII. FUNDS ARE ALLOCATED USING A FORMULA BASED ON POPULATION, POVERTY, AND HOUSING OVERCROWDING, WITH THE POVERTY FACTOR CARRYING A DOUBLE WEIGHT. FOR THE CDBG INSULAR AREAS PROGRAM, HUD ANNUALLY ALLOCATES CDBG GRANTS TO FOUR DESIGNATED AREAS: AMERICAN SAMOA; GUAM; NORTHERN MARIANA ISLANDS; AND THE U.S. VIRGIN ISLANDS. THE FUNDS ARE ALLOCATED IN PROPORTION TO THE POPULATIONS OF THE ELIGIBLE TERRITORIES. THE PROGRAM IS ADMINISTERED BY HUD'S FIELD OFFICES IN PUERTO RICO AND HAWAII. UNDER THE STATE CDBG PROGRAM, STATES PASS THROUGH CDBG GRANTS TO UNITS OF GENERAL LOCAL GOVERNMENT. ANNUALLY, EACH STATE DEVELOPS FUNDING PRIORITIES AND CRITERIA FOR SELECTING PROJECTS. SINCE STATES ARE IN THE BEST POSITION TO KNOW, AND TO RESPOND TO, THE NEEDS OF LOCAL GOVERNMENTS, CONGRESS AMENDED THE HOUSING AND COMMUNITY DEVELOPMENT ACT OF 1974 (HCD ACT) IN 1981 TO GIVE EACH STATE THE OPPORTUNITY TO ADMINISTER CDBG FUNDS FOR NON-ENTITLEMENT AREAS. NON-ENTITLEMENT AREAS INCLUDE THOSE UNITS OF GENERAL LOCAL GOVERNMENT WHICH DO NOT RECEIVE CDBG FUNDS DIRECTLY FROM HUD. GENERALLY, NON-ENTITLEMENT AREAS ARE CITIES WITH POPULATIONS OF LESS THAN 50,000 (EXCEPT CITIES THAT ARE DESIGNATED PRINCIPAL CITIES OF METROPOLITAN STATISTICAL AREAS), AND COUNTIES WITH POPULATIONS OF LESS THAN 200,000. CURRENT CDBG AWARDS AND ALLOCATIONS ARE INCLUDED IN THIS LIST OF HUD COMMUNITY PLANNING AND DEVELOPMENT (CPD) AWARDS AND ALLOCATIONS LOCATED AT: HTTPS://WWW.HUDEXCHANGE.INFO/GRANTEES/ALLOCATIONS-AWARDS/; ACTIVITIES TO BE PERFORMED: CDBG FUNDS MAY BE USED FOR ACTIVITIES WHICH INCLUDE, BUT ARE NOT LIMITED TO: ACQUISITION OF REAL PROPERTY; RELOCATION AND DEMOLITION; REHABILITATION OF RESIDENTIAL AND NON-RESIDENTIAL STRUCTURES; CONSTRUCTION OF PUBLIC FACILITIES AND IMPROVEMENTS, SUCH AS WATER AND SEWER FACILITIES, STREETS, NEIGHBORHOOD CENTERS, AND THE CONVERSION OF SCHOOL BUILDINGS FOR ELIGIBLE PURPOSES; PUBLIC SERVICES, WITHIN CERTAIN LIMITS; ACTIVITIES RELATING TO ENERGY CONSERVATION AND RENEWABLE ENERGY RESOURCES; PROVISION OF ASSISTANCE TO PROFIT-MOTIVATED BUSINESSES TO CARRY OUT ECONOMIC DEVELOPMENT AND JOB CREATION/RETENTION ACTIVITIES. EACH ACTIVITY MUST MEET ONE OF THE FOLLOWING NATIONAL OBJECTIVES FOR THE PROGRAM: BENEFIT LOW- AND MODERATE-INCOME PERSONS, PREVENTION OR ELIMINATION OF SLUMS OR BLIGHT, OR ADDRESS COMMUNITY DEVELOPMENT NEEDS HAVING A PARTICULAR URGENCY BECAUSE EXISTING CONDITIONS POSE A SERIOUS AND IMMEDIATE THREAT TO THE HEALTH OR WELFARE OF THE COMMUNITY FOR WHICH OTHER FUNDING IS NOT AVAILABLE. GENERALLY, THE FOLLOWING TYPES OF ACTIVITIES ARE INELIGIBLE: ACQUISITION, CONSTRUCTION, OR RECONSTRUCTION OF BUILDINGS FOR THE GENERAL CONDUCT OF GOVERNMENT; POLITICAL ACTIVITIES; CERTAIN INCOME PAYMENTS; CONSTRUCTION OF NEW HOUSING (WITH SOME EXCEPTIONS). UNDER THE STATE CDBG PROGRAM, STATES MAY USE $100,000 PLUS UP TO A MAXIMUM OF THREE PERCENT OF ITS CDBG ALLOCATION. AMOUNTS EXPENDED ON ADMINISTRATION IN EXCESS OF $100,000 MUST BE MATCHED. STATES MAY EXPEND UP TO THREE PERCENT OF THEIR CDBG ALLOCATION ON TECHNICAL ASSISTANCE ACTIVITIES. HOWEVER, THE TOTAL A STATE SPENDS ON BOTH ADMINISTRATIVE AND TECHNICAL ASSISTANCE EXPENSES MAY NOT EXCEED $100,000 PLUS THREE PERCENT OF THE STATE'S ALLOCATION. CPD HAS DEVELOPED PROFILES THAT DISPLAY GRANTEE-REPORTED ACCOMPLISHMENTS FOR SELECTED HOUSING, ECONOMIC DEVELOPMENT, PUBLIC IMPROVEMENT, AND PUBLIC SERVICE ACTIVITIES. PROFILES FOR GRANTEES WILL VARY, AS GRANTEES HAVE FLEXIBILITY IN DETERMINING THE HOUSING, ECONOMIC, AND COMMUNITY DEVELOPMENT ACTIVITIES THEY CARRY OUT WITH CDBG FUNDS. THE MOST RECENT ACCOMPLISHMENTS CAN BE VIEWED WITHIN THE NATIONAL ACCOMPLISHMENT REPORTS LOCATED AT: HTTPS://WWW.HUDEXCHANGE.INFO/PROGRAMS/CDBG/CDBG-ACCOMPLISHMENT-REPORTS/; EXPECTED OUTCOMES: THE CDBG PROGRAM REINFORCES SEVERAL IMPORTANT VALUES AND PRINCIPLES OF COMMUNITY DEVELOPMENT: PROGRAM FLEXIBILITY TO EMPOWER PEOPLE AND COMMUNITIES TO DESIGN AND IMPLEMENT STRATEGIES TAILORED TO THEIR OWN NEEDS AND PRIORITIES; AN EMPHASIS ON CONSOLIDATED PLANNING THAT EXPANDS AND STRENGTHENS PARTNERSHIPS AMONG ALL LEVELS OF GOVERNMENT AND THE PRIVATE SECTOR IN ENHANCING COMMUNITY DEVELOPMENT; TECHNICAL ASSISTANCE ACTIVITIES AND SET-ASIDE FOR GRANTEES TO BUILD THE CAPACITY OF THESE PARTNERS. EACH CDBG GRANTEE’S EXPECTED OUTCOMES ARE DESCRIBED AS GOALS IN THEIR CONSOLIDATED PLAN. THE MOST RECENT CONSOLIDATED PLANS CAN BE VIEWED AT: HTTPS://WWW.HUDEXCHANGE.INFO/GRANTEES/REPORTS/#CONSOLIDATED-PLANS-ANNUAL-ACTION-PLANS-AND-CAPERS; INTENDED BENEFICIARIES: OVER A 1, 2, OR 3-YEAR PERIOD, AS SELECTED BY THE GRANTEE, NOT LESS THAN 70 PERCENT OF CDBG FUNDS MUST BE USED FOR ACTIVITIES THAT BENEFIT LOW- AND MODERATE-INCOME PERSONS. HUD DOES NOT PROVIDE CDBG ASSISTANCE DIRECTLY TO INDIVIDUALS, BUSINESSES, NONPROFIT OR ORGANIZATIONS OR OTHER NON-GOVERNMENTAL ENTITIES. INDIVIDUALS WHO ARE INTERESTED IN PARTICIPATING IN THIS PROGRAM, SHOULD CONTACT THEIR LOCAL MUNICIPAL OR COUNTY OFFICIALS TO FIND OUT HOW THE PROGRAM OPERATES IN THEIR COMMUNITY. PARTICIPATION REQUIREMENTS MAY DIFFER FROM ONE GRANTEE TO ANOTHER. WITH THE EXCEPTION OF THE STATE CDBG PROGRAM, THE LOCAL GOVERNMENT GRANTEE ADMINISTERS THE CDBG PROGRAM AND DETERMINES WHICH LOCAL PROJECTS RECEIVE FUNDING. ELIGIBLE GRANTEES ARE AS FOLLOWS: PRINCIPAL CITIES OF METROPOLITAN STATISTICAL AREAS (MSAS); OTHER METROPOLITAN CITIES WITH POPULATIONS OF AT LEAST 50,000; QUALIFIED URBAN COUNTIES WITH POPULATIONS OF AT LEAST 200,000 (EXCLUDING THE POPULATION OF ENTITLED CITIES); STATES AND INSULAR AREAS. THE DISTRICT OF COLUMBIA IS FUNDED UNDER THE CDBG ENTITLEMENT PROGRAM. THE STATE OF HAWAII DOES NOT PARTICIPATE, AND HUD ALLOCATES THE STATE'S SHARE OF FUNDS TO THE THREE HAWAII NON-ENTITLED COUNTIES. THE STATES ADMINISTER CDBG FUNDS IN THE STATE CDBG PROGRAM. SINCE STATES ARE IN THE BEST POSITION TO KNOW, AND TO RESPOND TO, THE NEEDS OF LOCAL GOVERNMENTS, CONGRESS AMENDED THE HOUSING AND COMMUNITY DEVELOPMENT ACT OF 1974 (HCD ACT) IN 1981 TO GIVE EACH STATE THE OPPORTUNITY TO ADMINISTER CDBG FUNDS FOR NON-ENTITLEMENT AREAS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

OXIDATION IN INFLAMMATION AND CARDIOVASCULAR DISEASE

ENTITLED CITIES

PULMONARY VASCULAR DISEASE PHENOMICS PROGRAM (PVDOMICS) DATA COORDINATING CENTER

ENTITLED CITIES

VASCULAR CELL FUNCTION AND ATHEROSCLEROSIS

PURPOSE: THE COMMUNITY DEVELOPMENT BLOCK GRANT (CDBG) PROGRAM PROVIDES ANNUAL GRANTS ON A FORMULA BASIS TO STATES, CITIES, AND COUNTIES TO DEVELOP VIABLE URBAN COMMUNITIES BY PROVIDING DECENT HOUSING AND A SUITABLE LIVING ENVIRONMENT, AND BY EXPANDING ECONOMIC OPPORTUNITIES, PRINCIPALLY FOR LOW- AND MODERATE-INCOME PERSONS. THE PROGRAM IS AUTHORIZED UNDER TITLE 1 OF THE HOUSING AND COMMUNITY DEVELOPMENT ACT OF 1974, PUBLIC LAW 93-383, AS AMENDED 42 U.S.C. 5301 ET SEQ. THE CDBG PROGRAM COVERS FOUR DISTINCT PROGRAMS, EACH WITH THEIR OWN SET OF GOVERNING REGULATIONS: CDBG ENTITLEMENT, CDBG NON-ENTITLED COUNTIES IN HAWAII, CDBG INSULAR AREAS, AND STATE CDBG. IN THE CDBG ENTITLEMENT PROGRAM, HUD AWARDS GRANTS TO ENTITLEMENT COMMUNITY GRANTEES TO CARRY OUT A WIDE RANGE OF COMMUNITY DEVELOPMENT ACTIVITIES. ENTITLEMENT COMMUNITIES DEVELOP THEIR OWN PROGRAMS AND FUNDING PRIORITIES. IN THE CDBG NON-ENTITLED COUNTIES IN HAWAII PROGRAM, THREE COUNTIES QUALIFY: HAWAII, KAUAI, AND MAUI. THE FY 2004 APPROPRIATIONS ACT REQUIRED THE GOVERNOR OF HAWAII TO DECIDE IF THE STATE WISHED TO PARTICIPATE IN THE STATE CDBG PROGRAM BY JULY 31, 2004. THE STATE MADE THE DECISION NOT TO PARTICIPATE IN THE PROGRAM. AS A RESULT OF THIS DECISION HUD'S HONOLULU FIELD OFFICE ADMINISTERS THE NON-ENTITLED GRANTS IN HAWAII. FUNDS ARE ALLOCATED USING A FORMULA BASED ON POPULATION, POVERTY, AND HOUSING OVERCROWDING, WITH THE POVERTY FACTOR CARRYING A DOUBLE WEIGHT. FOR THE CDBG INSULAR AREAS PROGRAM, HUD ANNUALLY ALLOCATES CDBG GRANTS TO FOUR DESIGNATED AREAS: AMERICAN SAMOA; GUAM; NORTHERN MARIANA ISLANDS; AND THE U.S. VIRGIN ISLANDS. THE FUNDS ARE ALLOCATED IN PROPORTION TO THE POPULATIONS OF THE ELIGIBLE TERRITORIES. THE PROGRAM IS ADMINISTERED BY HUD'S FIELD OFFICES IN PUERTO RICO AND HAWAII. UNDER THE STATE CDBG PROGRAM, STATES PASS THROUGH CDBG GRANTS TO UNITS OF GENERAL LOCAL GOVERNMENT. ANNUALLY, EACH STATE DEVELOPS FUNDING PRIORITIES AND CRITERIA FOR SELECTING PROJECTS. SINCE STATES ARE IN THE BEST POSITION TO KNOW, AND TO RESPOND TO, THE NEEDS OF LOCAL GOVERNMENTS, CONGRESS AMENDED THE HOUSING AND COMMUNITY DEVELOPMENT ACT OF 1974 (HCD ACT) IN 1981 TO GIVE EACH STATE THE OPPORTUNITY TO ADMINISTER CDBG FUNDS FOR NON-ENTITLEMENT AREAS. NON-ENTITLEMENT AREAS INCLUDE THOSE UNITS OF GENERAL LOCAL GOVERNMENT WHICH DO NOT RECEIVE CDBG FUNDS DIRECTLY FROM HUD. GENERALLY, NON-ENTITLEMENT AREAS ARE CITIES WITH POPULATIONS OF LESS THAN 50,000 (EXCEPT CITIES THAT ARE DESIGNATED PRINCIPAL CITIES OF METROPOLITAN STATISTICAL AREAS), AND COUNTIES WITH POPULATIONS OF LESS THAN 200,000. CURRENT CDBG AWARDS AND ALLOCATIONS ARE INCLUDED IN THIS LIST OF HUD COMMUNITY PLANNING AND DEVELOPMENT (CPD) AWARDS AND ALLOCATIONS LOCATED AT: HTTPS://WWW.HUDEXCHANGE.INFO/GRANTEES/ALLOCATIONS-AWARDS/; ACTIVITIES TO BE PERFORMED: CDBG FUNDS MAY BE USED FOR ACTIVITIES WHICH INCLUDE, BUT ARE NOT LIMITED TO: ACQUISITION OF REAL PROPERTY; RELOCATION AND DEMOLITION; REHABILITATION OF RESIDENTIAL AND NON-RESIDENTIAL STRUCTURES; CONSTRUCTION OF PUBLIC FACILITIES AND IMPROVEMENTS, SUCH AS WATER AND SEWER FACILITIES, STREETS, NEIGHBORHOOD CENTERS, AND THE CONVERSION OF SCHOOL BUILDINGS FOR ELIGIBLE PURPOSES; PUBLIC SERVICES, WITHIN CERTAIN LIMITS; ACTIVITIES RELATING TO ENERGY CONSERVATION AND RENEWABLE ENERGY RESOURCES; PROVISION OF ASSISTANCE TO PROFIT-MOTIVATED BUSINESSES TO CARRY OUT ECONOMIC DEVELOPMENT AND JOB CREATION/RETENTION ACTIVITIES. EACH ACTIVITY MUST MEET ONE OF THE FOLLOWING NATIONAL OBJECTIVES FOR THE PROGRAM: BENEFIT LOW- AND MODERATE-INCOME PERSONS, PREVENTION OR ELIMINATION OF SLUMS OR BLIGHT, OR ADDRESS COMMUNITY DEVELOPMENT NEEDS HAVING A PARTICULAR URGENCY BECAUSE EXISTING CONDITIONS POSE A SERIOUS AND IMMEDIATE THREAT TO THE HEALTH OR WELFARE OF THE COMMUNITY FOR WHICH OTHER FUNDING IS NOT AVAILABLE. GENERALLY, THE FOLLOWING TYPES OF ACTIVITIES ARE INELIGIBLE: ACQUISITION, CONSTRUCTION, OR RECONSTRUCTION OF BUILDINGS FOR THE GENERAL CONDUCT OF GOVERNMENT; POLITICAL ACTIVITIES; CERTAIN INCOME PAYMENTS; CONSTRUCTION OF NEW HOUSING (WITH SOME EXCEPTIONS). UNDER THE STATE CDBG PROGRAM, STATES MAY USE $100,000 PLUS UP TO A MAXIMUM OF THREE PERCENT OF ITS CDBG ALLOCATION. AMOUNTS EXPENDED ON ADMINISTRATION IN EXCESS OF $100,000 MUST BE MATCHED. STATES MAY EXPEND UP TO THREE PERCENT OF THEIR CDBG ALLOCATION ON TECHNICAL ASSISTANCE ACTIVITIES. HOWEVER, THE TOTAL A STATE SPENDS ON BOTH ADMINISTRATIVE AND TECHNICAL ASSISTANCE EXPENSES MAY NOT EXCEED $100,000 PLUS THREE PERCENT OF THE STATE'S ALLOCATION. CPD HAS DEVELOPED PROFILES THAT DISPLAY GRANTEE-REPORTED ACCOMPLISHMENTS FOR SELECTED HOUSING, ECONOMIC DEVELOPMENT, PUBLIC IMPROVEMENT, AND PUBLIC SERVICE ACTIVITIES. PROFILES FOR GRANTEES WILL VARY, AS GRANTEES HAVE FLEXIBILITY IN DETERMINING THE HOUSING, ECONOMIC, AND COMMUNITY DEVELOPMENT ACTIVITIES THEY CARRY OUT WITH CDBG FUNDS. THE MOST RECENT ACCOMPLISHMENTS CAN BE VIEWED WITHIN THE NATIONAL ACCOMPLISHMENT REPORTS LOCATED AT: HTTPS://WWW.HUDEXCHANGE.INFO/PROGRAMS/CDBG/CDBG-ACCOMPLISHMENT-REPORTS/; EXPECTED OUTCOMES: THE CDBG PROGRAM REINFORCES SEVERAL IMPORTANT VALUES AND PRINCIPLES OF COMMUNITY DEVELOPMENT: PROGRAM FLEXIBILITY TO EMPOWER PEOPLE AND COMMUNITIES TO DESIGN AND IMPLEMENT STRATEGIES TAILORED TO THEIR OWN NEEDS AND PRIORITIES; AN EMPHASIS ON CONSOLIDATED PLANNING THAT EXPANDS AND STRENGTHENS PARTNERSHIPS AMONG ALL LEVELS OF GOVERNMENT AND THE PRIVATE SECTOR IN ENHANCING COMMUNITY DEVELOPMENT; TECHNICAL ASSISTANCE ACTIVITIES AND SET-ASIDE FOR GRANTEES TO BUILD THE CAPACITY OF THESE PARTNERS. EACH CDBG GRANTEE’S EXPECTED OUTCOMES ARE DESCRIBED AS GOALS IN THEIR CONSOLIDATED PLAN. THE MOST RECENT CONSOLIDATED PLANS CAN BE VIEWED AT: HTTPS://WWW.HUDEXCHANGE.INFO/GRANTEES/REPORTS/#CONSOLIDATED-PLANS-ANNUAL-ACTION-PLANS-AND-CAPERS; INTENDED BENEFICIARIES: OVER A 1, 2, OR 3-YEAR PERIOD, AS SELECTED BY THE GRANTEE, NOT LESS THAN 70 PERCENT OF CDBG FUNDS MUST BE USED FOR ACTIVITIES THAT BENEFIT LOW- AND MODERATE-INCOME PERSONS. HUD DOES NOT PROVIDE CDBG ASSISTANCE DIRECTLY TO INDIVIDUALS, BUSINESSES, NONPROFIT OR ORGANIZATIONS OR OTHER NON-GOVERNMENTAL ENTITIES. INDIVIDUALS WHO ARE INTERESTED IN PARTICIPATING IN THIS PROGRAM, SHOULD CONTACT THEIR LOCAL MUNICIPAL OR COUNTY OFFICIALS TO FIND OUT HOW THE PROGRAM OPERATES IN THEIR COMMUNITY. PARTICIPATION REQUIREMENTS MAY DIFFER FROM ONE GRANTEE TO ANOTHER. WITH THE EXCEPTION OF THE STATE CDBG PROGRAM, THE LOCAL GOVERNMENT GRANTEE ADMINISTERS THE CDBG PROGRAM AND DETERMINES WHICH LOCAL PROJECTS RECEIVE FUNDING. ELIGIBLE GRANTEES ARE AS FOLLOWS: PRINCIPAL CITIES OF METROPOLITAN STATISTICAL AREAS (MSAS); OTHER METROPOLITAN CITIES WITH POPULATIONS OF AT LEAST 50,000; QUALIFIED URBAN COUNTIES WITH POPULATIONS OF AT LEAST 200,000 (EXCLUDING THE POPULATION OF ENTITLED CITIES); STATES AND INSULAR AREAS. THE DISTRICT OF COLUMBIA IS FUNDED UNDER THE CDBG ENTITLEMENT PROGRAM. THE STATE OF HAWAII DOES NOT PARTICIPATE, AND HUD ALLOCATES THE STATE'S SHARE OF FUNDS TO THE THREE HAWAII NON-ENTITLED COUNTIES. THE STATES ADMINISTER CDBG FUNDS IN THE STATE CDBG PROGRAM. SINCE STATES ARE IN THE BEST POSITION TO KNOW, AND TO RESPOND TO, THE NEEDS OF LOCAL GOVERNMENTS, CONGRESS AMENDED THE HOUSING AND COMMUNITY DEVELOPMENT ACT OF 1974 (HCD ACT) IN 1981 TO GIVE EACH STATE THE OPPORTUNITY TO ADMINISTER CDBG FUNDS FOR NON-ENTITLEMENT AREAS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

STRUCTURE AND FUNCTION OF BETA3 INTEGRINS ON BLOOD CELLS

ENTITLED CITIES

PURPOSE: THE COMMUNITY DEVELOPMENT BLOCK GRANT (CDBG) PROGRAM PROVIDES ANNUAL GRANTS ON A FORMULA BASIS TO STATES, CITIES, AND COUNTIES TO DEVELOP VIABLE URBAN COMMUNITIES BY PROVIDING DECENT HOUSING AND A SUITABLE LIVING ENVIRONMENT, AND BY EXPANDING ECONOMIC OPPORTUNITIES, PRINCIPALLY FOR LOW- AND MODERATE-INCOME PERSONS. THE PROGRAM IS AUTHORIZED UNDER TITLE 1 OF THE HOUSING AND COMMUNITY DEVELOPMENT ACT OF 1974, PUBLIC LAW 93-383, AS AMENDED 42 U.S.C. 5301 ET SEQ. THE CDBG PROGRAM COVERS FOUR DISTINCT PROGRAMS, EACH WITH THEIR OWN SET OF GOVERNING REGULATIONS: CDBG ENTITLEMENT, CDBG NON-ENTITLED COUNTIES IN HAWAII, CDBG INSULAR AREAS, AND STATE CDBG. IN THE CDBG ENTITLEMENT PROGRAM, HUD AWARDS GRANTS TO ENTITLEMENT COMMUNITY GRANTEES TO CARRY OUT A WIDE RANGE OF COMMUNITY DEVELOPMENT ACTIVITIES. ENTITLEMENT COMMUNITIES DEVELOP THEIR OWN PROGRAMS AND FUNDING PRIORITIES. IN THE CDBG NON-ENTITLED COUNTIES IN HAWAII PROGRAM, THREE COUNTIES QUALIFY: HAWAII, KAUAI, AND MAUI. THE FY 2004 APPROPRIATIONS ACT REQUIRED THE GOVERNOR OF HAWAII TO DECIDE IF THE STATE WISHED TO PARTICIPATE IN THE STATE CDBG PROGRAM BY JULY 31, 2004. THE STATE MADE THE DECISION NOT TO PARTICIPATE IN THE PROGRAM. AS A RESULT OF THIS DECISION HUD'S HONOLULU FIELD OFFICE ADMINISTERS THE NON-ENTITLED GRANTS IN HAWAII. FUNDS ARE ALLOCATED USING A FORMULA BASED ON POPULATION, POVERTY, AND HOUSING OVERCROWDING, WITH THE POVERTY FACTOR CARRYING A DOUBLE WEIGHT. FOR THE CDBG INSULAR AREAS PROGRAM, HUD ANNUALLY ALLOCATES CDBG GRANTS TO FOUR DESIGNATED AREAS: AMERICAN SAMOA; GUAM; NORTHERN MARIANA ISLANDS; AND THE U.S. VIRGIN ISLANDS. THE FUNDS ARE ALLOCATED IN PROPORTION TO THE POPULATIONS OF THE ELIGIBLE TERRITORIES. THE PROGRAM IS ADMINISTERED BY HUD'S FIELD OFFICES IN PUERTO RICO AND HAWAII. UNDER THE STATE CDBG PROGRAM, STATES PASS THROUGH CDBG GRANTS TO UNITS OF GENERAL LOCAL GOVERNMENT. ANNUALLY, EACH STATE DEVELOPS FUNDING PRIORITIES AND CRITERIA FOR SELECTING PROJECTS. SINCE STATES ARE IN THE BEST POSITION TO KNOW, AND TO RESPOND TO, THE NEEDS OF LOCAL GOVERNMENTS, CONGRESS AMENDED THE HOUSING AND COMMUNITY DEVELOPMENT ACT OF 1974 (HCD ACT) IN 1981 TO GIVE EACH STATE THE OPPORTUNITY TO ADMINISTER CDBG FUNDS FOR NON-ENTITLEMENT AREAS. NON-ENTITLEMENT AREAS INCLUDE THOSE UNITS OF GENERAL LOCAL GOVERNMENT WHICH DO NOT RECEIVE CDBG FUNDS DIRECTLY FROM HUD. GENERALLY, NON-ENTITLEMENT AREAS ARE CITIES WITH POPULATIONS OF LESS THAN 50,000 (EXCEPT CITIES THAT ARE DESIGNATED PRINCIPAL CITIES OF METROPOLITAN STATISTICAL AREAS), AND COUNTIES WITH POPULATIONS OF LESS THAN 200,000. CURRENT CDBG AWARDS AND ALLOCATIONS ARE INCLUDED IN THIS LIST OF HUD COMMUNITY PLANNING AND DEVELOPMENT (CPD) AWARDS AND ALLOCATIONS LOCATED AT: HTTPS://WWW.HUDEXCHANGE.INFO/GRANTEES/ALLOCATIONS-AWARDS/; ACTIVITIES TO BE PERFORMED: CDBG FUNDS MAY BE USED FOR ACTIVITIES WHICH INCLUDE, BUT ARE NOT LIMITED TO: ACQUISITION OF REAL PROPERTY; RELOCATION AND DEMOLITION; REHABILITATION OF RESIDENTIAL AND NON-RESIDENTIAL STRUCTURES; CONSTRUCTION OF PUBLIC FACILITIES AND IMPROVEMENTS, SUCH AS WATER AND SEWER FACILITIES, STREETS, NEIGHBORHOOD CENTERS, AND THE CONVERSION OF SCHOOL BUILDINGS FOR ELIGIBLE PURPOSES; PUBLIC SERVICES, WITHIN CERTAIN LIMITS; ACTIVITIES RELATING TO ENERGY CONSERVATION AND RENEWABLE ENERGY RESOURCES; PROVISION OF ASSISTANCE TO PROFIT-MOTIVATED BUSINESSES TO CARRY OUT ECONOMIC DEVELOPMENT AND JOB CREATION/RETENTION ACTIVITIES. EACH ACTIVITY MUST MEET ONE OF THE FOLLOWING NATIONAL OBJECTIVES FOR THE PROGRAM: BENEFIT LOW- AND MODERATE-INCOME PERSONS, PREVENTION OR ELIMINATION OF SLUMS OR BLIGHT, OR ADDRESS COMMUNITY DEVELOPMENT NEEDS HAVING A PARTICULAR URGENCY BECAUSE EXISTING CONDITIONS POSE A SERIOUS AND IMMEDIATE THREAT TO THE HEALTH OR WELFARE OF THE COMMUNITY FOR WHICH OTHER FUNDING IS NOT AVAILABLE. GENERALLY, THE FOLLOWING TYPES OF ACTIVITIES ARE INELIGIBLE: ACQUISITION, CONSTRUCTION, OR RECONSTRUCTION OF BUILDINGS FOR THE GENERAL CONDUCT OF GOVERNMENT; POLITICAL ACTIVITIES; CERTAIN INCOME PAYMENTS; CONSTRUCTION OF NEW HOUSING (WITH SOME EXCEPTIONS). UNDER THE STATE CDBG PROGRAM, STATES MAY USE $100,000 PLUS UP TO A MAXIMUM OF THREE PERCENT OF ITS CDBG ALLOCATION. AMOUNTS EXPENDED ON ADMINISTRATION IN EXCESS OF $100,000 MUST BE MATCHED. STATES MAY EXPEND UP TO THREE PERCENT OF THEIR CDBG ALLOCATION ON TECHNICAL ASSISTANCE ACTIVITIES. HOWEVER, THE TOTAL A STATE SPENDS ON BOTH ADMINISTRATIVE AND TECHNICAL ASSISTANCE EXPENSES MAY NOT EXCEED $100,000 PLUS THREE PERCENT OF THE STATE'S ALLOCATION. CPD HAS DEVELOPED PROFILES THAT DISPLAY GRANTEE-REPORTED ACCOMPLISHMENTS FOR SELECTED HOUSING, ECONOMIC DEVELOPMENT, PUBLIC IMPROVEMENT, AND PUBLIC SERVICE ACTIVITIES. PROFILES FOR GRANTEES WILL VARY, AS GRANTEES HAVE FLEXIBILITY IN DETERMINING THE HOUSING, ECONOMIC, AND COMMUNITY DEVELOPMENT ACTIVITIES THEY CARRY OUT WITH CDBG FUNDS. THE MOST RECENT ACCOMPLISHMENTS CAN BE VIEWED WITHIN THE NATIONAL ACCOMPLISHMENT REPORTS LOCATED AT: HTTPS://WWW.HUDEXCHANGE.INFO/PROGRAMS/CDBG/CDBG-ACCOMPLISHMENT-REPORTS/; EXPECTED OUTCOMES: THE CDBG PROGRAM REINFORCES SEVERAL IMPORTANT VALUES AND PRINCIPLES OF COMMUNITY DEVELOPMENT: PROGRAM FLEXIBILITY TO EMPOWER PEOPLE AND COMMUNITIES TO DESIGN AND IMPLEMENT STRATEGIES TAILORED TO THEIR OWN NEEDS AND PRIORITIES; AN EMPHASIS ON CONSOLIDATED PLANNING THAT EXPANDS AND STRENGTHENS PARTNERSHIPS AMONG ALL LEVELS OF GOVERNMENT AND THE PRIVATE SECTOR IN ENHANCING COMMUNITY DEVELOPMENT; TECHNICAL ASSISTANCE ACTIVITIES AND SET-ASIDE FOR GRANTEES TO BUILD THE CAPACITY OF THESE PARTNERS. EACH CDBG GRANTEE’S EXPECTED OUTCOMES ARE DESCRIBED AS GOALS IN THEIR CONSOLIDATED PLAN. THE MOST RECENT CONSOLIDATED PLANS CAN BE VIEWED AT: HTTPS://WWW.HUDEXCHANGE.INFO/GRANTEES/REPORTS/#CONSOLIDATED-PLANS-ANNUAL-ACTION-PLANS-AND-CAPERS; INTENDED BENEFICIARIES: OVER A 1, 2, OR 3-YEAR PERIOD, AS SELECTED BY THE GRANTEE, NOT LESS THAN 70 PERCENT OF CDBG FUNDS MUST BE USED FOR ACTIVITIES THAT BENEFIT LOW- AND MODERATE-INCOME PERSONS. HUD DOES NOT PROVIDE CDBG ASSISTANCE DIRECTLY TO INDIVIDUALS, BUSINESSES, NONPROFIT OR ORGANIZATIONS OR OTHER NON-GOVERNMENTAL ENTITIES. INDIVIDUALS WHO ARE INTERESTED IN PARTICIPATING IN THIS PROGRAM, SHOULD CONTACT THEIR LOCAL MUNICIPAL OR COUNTY OFFICIALS TO FIND OUT HOW THE PROGRAM OPERATES IN THEIR COMMUNITY. PARTICIPATION REQUIREMENTS MAY DIFFER FROM ONE GRANTEE TO ANOTHER. WITH THE EXCEPTION OF THE STATE CDBG PROGRAM, THE LOCAL GOVERNMENT GRANTEE ADMINISTERS THE CDBG PROGRAM AND DETERMINES WHICH LOCAL PROJECTS RECEIVE FUNDING. ELIGIBLE GRANTEES ARE AS FOLLOWS: PRINCIPAL CITIES OF METROPOLITAN STATISTICAL AREAS (MSAS); OTHER METROPOLITAN CITIES WITH POPULATIONS OF AT LEAST 50,000; QUALIFIED URBAN COUNTIES WITH POPULATIONS OF AT LEAST 200,000 (EXCLUDING THE POPULATION OF ENTITLED CITIES); STATES AND INSULAR AREAS. THE DISTRICT OF COLUMBIA IS FUNDED UNDER THE CDBG ENTITLEMENT PROGRAM. THE STATE OF HAWAII DOES NOT PARTICIPATE, AND HUD ALLOCATES THE STATE'S SHARE OF FUNDS TO THE THREE HAWAII NON-ENTITLED COUNTIES. THE STATES ADMINISTER CDBG FUNDS IN THE STATE CDBG PROGRAM. SINCE STATES ARE IN THE BEST POSITION TO KNOW, AND TO RESPOND TO, THE NEEDS OF LOCAL GOVERNMENTS, CONGRESS AMENDED THE HOUSING AND COMMUNITY DEVELOPMENT ACT OF 1974 (HCD ACT) IN 1981 TO GIVE EACH STATE THE OPPORTUNITY TO ADMINISTER CDBG FUNDS FOR NON-ENTITLEMENT AREAS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

COMMUNITY DEVELOPMENT BLOCK GRANTS/ENTITLEMENT GRANTS

COMMUNITY DEVELOPMENT BLOCK GRANTS/ENTITLEMENT GRANTS

IMPROVE EXISTING AIRPORT

THE PROJECT WILL CONVERT THE EXISTING WASTEWATER TREATMENT PLANT FROM A LEMNA TREATMENT SYSTEM TO A MORE CONVENTIONAL TERTIARY TREATMENT SYSTEM THAT INCORPORATES BIOLOGICAL NUTRIENT REMOVAL. IT WILL ALSO INCREASE TREATMENT CAPACITY WHICH WILL ALLOW FOR FUTURE ECONOMIC GROWTH.

PILOT BROADBAND LOAN GRANT COMBO - GRANT

IMPROVE EXISTING AIRPORT

HOME INVESTMENT PARTNERSHIPS PROGRAM

ACUTE HUMORAL REJECTION OF RENAL ALLOGRAFTS

IMPROVE EXISTING AIRPORT

IMPROVE EXISTING AIRPORT

2016 SEC 5337 SOGR

PURPOSE: EXTEND/EXPAND RUNWAY. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT EXPANDS RUNWAY 15/33 AN ADDITIONAL 50 FEET IN WIDTH TO BRING THE AIRPORT INTO CONFORMITY WITH CURRENT STANDARDS. THIS GRANT FUNDS A PORTION OF PHASE 2, WHICH CONSISTS OF CONSTRUCTION. THIS GRANT IS ASSOCIATED WITH AN AIRPORT INFRASTRUCTURE GRANT THAT FUNDS THE REMAINING ELIGIBLE PORTION OF THE PHASE. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH LOVELAND, COLORADO.

ALCOHOL AND TISSUE INJURY FROM MECHANISMS TO TREATMENTS

BUS REPLACEMENT PROGRAM

NEIGHBORHOOD STABILIZATION PRG

HYALURONAN MATRICES IN VASCULAR PATHOLOGIES

APPLICATION PURPOSE: RECONSTRUCTION OF EIGHT (8) OF GCRTAS BLUE LINE LIGHT RAIL STATION PLATFORMS.; ACTIVITIES PERFORMED: THE EXISTING PLATFORMS WILL BE REMOVED AND REPLACED WITH CAST-IN-PLACE CONCRETE PLATFORMS CONTAINING EMBEDDED ADA-COMPLIANT TACTILE WARNING PANELS. A RAMP STRUCTURE AND ELEVATED SECTION OF PLATFORM WILL PROVIDE ADA-COMPLIANT ACCESS TO THE TRAINS.; EXPECTED OUTCOMES: STATIONS WILL BE ADA COMPLIANT WITH DESIGN FOCUSED ON SAFE AND SECURE EXPERIENCE ACCESSIBLE TO ALL RIDERS.; INTENDED BENEFICIARIES: GCRTA CUSTOMERS ACCESSING THE BLUE LINE PARTICULARLY THOSE WITH MOBILITY ISSUES.; SUBRECIPIENT ACTIVITIES: N/A

FY2018 SECTION 5337 SOGR

COMMUNITY DEVELOPMENT BLOCK GRANTS/ENTITLEMENT GRANTS

CLEVELAND ALZHEIMERS DISEASE RESEARCH CENTER - PROJECT SUMMARY THE CLEVELAND ALZHEIMER'S DISEASE RESEARCH CENTER (CADRC) IS A COLLABORATIVE EFFORT OF PHYSICIANS AND INVESTIGATORS FROM CASE WESTERN RESERVE UNIVERSITY (CWRU), CLEVELAND CLINIC FOUNDATION (CCF), METROHEALTH SYSTEM (MHS), UNIVERSITY HOSPITALS (UH), AND THE LOUIS STOKES CLEVELAND VA MEDICAL CENTER (LSCVAMC), TO FOSTER EXCELLENCE IN RESEARCH AND FACILITATE DISCOVERY AS AN ESTABLISHED NATIONAL INSTITUTE ON AGING (NIA) FUNDED ALZHEIMER'S DISEASE RESEARCH CENTER. THE CADRC REPRESENTS A RICH CLINICAL AND RESEARCH COMMUNITY AND AN ESTIMATED 220,000 OHIOANS WHO SUFFER FROM ALZHEIMER'S DISEASE (AD) OR AD-RELATED DEMENTIAS (ADRD). THE CADRC HAS 8 CORES AND A RESEARCH EDUCATION COMPONENT DESIGNED TO CREATE THE FOUNDATION THAT WILL ENHANCE THE RESEARCH EFFORTS OF THE NORTHEAST OHIO AD/ADRD RESEARCH COMMUNITY, AS WELL AS ADD UNIQUE VALUE TO THE NATIONAL ALZHEIMER'S DISEASE RESEARCH CENTERS (ADRC) PROGRAM AND OTHER NATIONAL AND INTERNATIONAL RESEARCH PROGRAMS. THE CADRC IS FOCUSED ON PARTICIPANTS THAT WILL HELP US UNDERSTAND THE PATHOBIOLOGY OF CLINICAL AND PATHOLOGICAL HETEROGENEITY OBSERVED IN DEMENTIA INCLUDING ATYPICAL AND AMNESTIC AD, DEMENTIA WITH LEWY BODIES, COGNITIVELY NORMAL INDIVIDUALS WITH DIFFERENT LEVELS OF GENETIC RISK FOR AD, AND DIVERSITY OF PARTICIPANT POPULATIONS (CLINICAL AND OUTREACH, RECRUITMENT, AND ENGAGEMENT CORES). TO SUPPORT THE CADRC GOALS, THE FOCUS WILL BE ON DEEP PHENOTYPING OF PARTICIPANTS WITH LONGITUDINAL AND SYSTEMATIC COGNITIVE, BEHAVIORAL AND MOTOR CHARACTERIZATION (CLINICAL CORE), GENETIC AND BIOFLUID BIOMARKER COLLECTION AND ANALYSIS (BIOMARKER CORE), IMAGING (NEUROIMAGING CORE), AND AUTOPSY AFTER DEATH (NEUROPATHOLOGY CORE). RESULTS WILL BE SHARED WITH THE RESEARCH COMMUNITY IN A TIMELY AND REGULAR MANNER TO ALLOW OTHER INVESTIGATORS TO BENEFIT FROM THE CADRC EFFORTS (DATA MANAGEMENT AND STATISTICS CORE). IN ADDITION, THE CADRC WILL TRAIN THE NEXT GENERATION OF INVESTIGATORS UTILIZING A RIGOROUS AND WELL-DESIGNED RESEARCH EDUCATION COMPONENT, SUPPORT TRANSLATION OF NEW LABORATORY FINDINGS THROUGH THE TRANSLATIONAL THERAPEUTICS CORE, AND SUPPORT HIGH RISK/HIGH GAIN PROJECTS THROUGH THE DEVELOPMENTAL PROGRAM AS A PART OF THE ADMINISTRATIVE CORE. THE ULTIMATE GOALS ARE TO ADVANCE THE PRECISION MEDICINE APPROACH TO DEMENTIA DIAGNOSIS AND TREATMENT, SUPPORT THE DEVELOPMENT OF EARLY STAGE INVESTIGATORS, ASSIST ALL STAGES OF INVESTIGATORS WITH TOOLS FOR PERFORMING HUMAN-BASED RESEARCH, AND BETTER ENGAGE UNDERREPRESENTED POPULATIONS IN AD/ADRD RESEARCH.

2017 BUS REPLACEMENT PROGRAM

FY 2010 PREVENTIVE MAINTENANCE

APPLICATION PURPOSE: GCRTA WILL REPLACE ITS EXISTING RAIL FLEET WHICH HAS REACHED THE END OF ITS USEFUL LIFE WITH NEW VEHICLES.; ACTIVITIES PERFORMED: PROCUREMENT AND REPLACEMENT OF RAIL VEHICLES.; EXPECTED OUTCOMES: IMPROVED RELIABILITY OF GCRTAS RAIL SYSTEM.; INTENDED BENEFICIARIES: RESIDENTS OF CUYAHOGA COUNTY.; SUBRECIPIENT ACTIVITIES: N/A

INFRASTRUCTURE FOR REBUILDING AMERICA GRANT FOR THE CITY OF CLEVELAND, OHIO.

IMPROVE EXISTING AIRPORT

EARLY HEAD START-CHILD CARE PARTNERSHIP

THE CLEVELAND CLINIC INNOVATION ACCELERATOR

FFY 2011 RAIL MOD

IMPROVE EXISTING AIRPORT

PATHOBIOLOGY OF ASTHMA

IMPROVE EXISTING AIRPORT

EARLY HEAD START/CHILD CARE PARTNERSHIP

5309 FY 2009 RAIL FORMULA

SEC 5337 STATE OF GOOD REPAIR

TRADE ADJUSTMENT ASSISTANCE COMMUNITY COLLEGE AND CAREER TRAINING

TRANSFORMING PEDIATRIC AMBULATORY CARE: THE PHYSICIAN EXTENSION TEAM

TIGER III LITTLE ITALY-UC STATION

IBUDILAST PHASE II TRIAL IN PROGRESSIVE MS

EASTERN GREAT LAKES PEDIATRIC CONSORTIUM FOR DISASTER RESPONSE

GUT MICROBIOTA AND CARDIOMETABOLIC DISEASES

CELL ADHESION AND SIGNALING IN BLOOD AND VASCULAR CELLS - PROJECT SUMMARY THIS APPLICATION HAS AS ITS THEME THE INTEGRINS, THEIR REGULATION AND THEIR CONTRIBUTION TO THE FUNCTIONAL RESPONSES OF BLOOD AND VASCULAR CELLS. THE INTEGRINS OF FOCUS ARE AMSS2 (MAC-1), AIIBSS3, AVSS3, AND A5SS1 BUT FINDINGS SHOULD APPLY TO BROADLY INTEGRINS. THE CELLS OF EMPHASIS ARE VASCULAR CELLS- ENDOTHELIAL CELLS, SMOOTH MUSCLE CELLS AND PERICYTES- AND BLOOD CELLS- LEUKOCYTES AND PLATELETS. ON THE BLOOD CELLS, THE CONJUGATION OF MAC-1 ON LEUKOCYTES AND GPIB ON PLATELETS WILL BE CONSIDERED. MAJOR EMPHASIS WILL BE PLACED ON THE MOLECULES THAT REGULATE INTEGRIN FUNCTION- KINDLINS, TALIN AND PAXILLIN- TO DETERMINE HOW THEY COLLABORATE TO REGULATE INTEGRIN ACTIVATION. THE FUNCTION OF THESE CYTOSKELETAL PROTEINS INDEPENDENT OF INTEGRIN ACTIVATING ACTIVITY WILL ALSO BE DISSECTED. THE PROGRAM CONSISTS OF THREE PROJECTS, EACH DIRECTED BY AN ACCOMPLISHED FACULTY MEMBER AT THEIR HOME INSTITUTIONS, CLEVELAND CLINIC, UNIVERSITY HOSPITALS OF CLEVELAND AND CASE WESTERN RESERVE UNIVERSITY WHICH ARE ALL CLOSELY LOCATED AND GOVERNED BY INTERINSTITUTIONAL AGREEMENTS. DR. EDWARD F. PLOW, PH.D. WILL SERVE AS PROGRAM DIRECTOR AND LEAD PROJECT 1. THIS PROJECT DEALS WITH THE MECHANISMS BY WHICH KINDLIN-2 REGULATES BOTH INTEGRIN-DEPENDENT AND INDEPENDENT RESPONSES OF BLOOD VESSEL CELLS. MOLECULAR, CELLULAR AND UNIQUE MOUSE MODELS ARE ALL BROUGHT TO BEAR TO DETERMINE HOW KINDLIN-2 SERVES AS A MASTER REGULATOR OF VASCULAR CELL RESPONSES. IN PROJECT 2, DR. JUN QIN WILL USE HIGH RESOLUTION STRUCTURAL APPROACHES IN COMBINATION WITH MUTAGENESIS AND CELLULAR STUDIES TO DETERMINE HOW TALIN REGULATE INTEGRIN ACTIVATION AND COOPERATES WITH KINDLINS AND PAXILLIN TO GAIN SUCH NOVEL INSIGHTS. HE WILL DETERMINE HOW TALIN INTERACTS WITH ACTIN TO CONTROL ORGANIZATION OF THE CYTOSKELETON. DR. DANIEL SIMON, M.D. WILL LEAD PROJECT 3 AND WILL CONSIDER HOW ENGAGEMENT OF INTEGRIN MAC-1 ON LEUKOCYTES AND GPIB ON PLATELETS REGULATES THE PARTICIPATION OF THESE CELLS IN INFLAMMATION AND THROMBOSIS. HIS STUDIES RANGE FROM BASIC STRUCTURAL APPROACHES TO TRANSLATIONAL STUDIES IN MICE AND TO HUMANS TO PROVIDE INSIGHTS INTO THEIR THROMBOTIC AND INFLAMMATORY CONTRIBUTIONS TO SYSTEMIC LUPUS ERYTHEMATOSUS. THE PROGRAM IS SUPPORTED BY TWO SCIENTIFIC CORES, PROTEIN EXPRESSION AND PURIFICATION (CORE B), AND ANIMAL MODELS AND TISSUE ANALYSIS (CORE C) AS WELL AS BY AN ADMINISTRATIVE CORE (AC1). A COMMON OBJECTIVE OF THE PROGRAM IS TO CONTINUE AND CREATE NEW COLLABORATIONS AMONG THE PROJECTS AND THEIR LEADERS TO RESOLVE THE STRUCTURAL AND BIOLOGICAL MECHANISMS THAT REGULATE THE FUNCTIONS OF INTEGRINS IN BLOOD AND VASCULAR CELLS. THE INFORMATION DERIVED FROM THESE STUDIES WILL PROVIDE INSIGHTS INTO BIOLOGICALLY IMPORTANT RESPONSES REGULATED BY INTEGRINS AND THEIR ACTIVATION THAT ARE RELEVANT TO THROMBOSIS AND CARDIOVASCULAR DISEASES.

HDL STRUCTURE AND ITS FUNCTION IN ATHEROSCLEROSIS

HUNTINGTON CLEVELAND SALINITY REDUCTION PROJECT

OTPPP - RED LINE WEST TRACK REHABILITATION

FRMI OF THE PERSON IDENTITY NETWORK: AGING AND APOE

5309 FY 2013 RAIL FORMULA

FFY 2008 RAIL MODERNIZATION

ATRIAL FIBRILLATION POST-GWAS: MECHANISMS TO TREATMENT - OVERALL COMPONENT PROJECT/SUMMARY ABSTRACT ATRIAL FIBRILLATION (AF), THE MOST COMMON CARDIAC ARRHYTHMIA, AFFLICTS THE U.S. AND WORLD WITH INCREASING PREVALENCE. AF INCIDENCE, PROGRESSION TO PERSISTENT AF, AND AF COMPLICATIONS, INCLUDING STROKE, ARE FED BY INCREASING OBESITY AND AGE. CURRENT THERAPIES ARE LIMITED BY RISKS AND LIMITED EFFICACY, WORSE AS AF PROGRESSES, BUT NO NEW PHARMACOLOGIC AGENTS HAVE BEEN APPROVED FOR AF IN >10 YEARS. WITH IDENTIFICATION OF >100 GENETIC LOCI THAT PREDISPOSE TO AF RISK IN GENOME-WIDE ASSOCIATION STUDIES (GWAS), THE HOPE HAS BEEN THAT GENETICS WOULD YIELD NOVEL THERAPEUTIC TARGETS. HOWEVER, EVEN FOR THE TOP LOCUS ON CHR. 4Q25 NEAR PITX2, A GENE INVOLVED IN FORMATION OF PULMONARY VEINS, THE TARGET OF AF ABLATION, MECHANISMS LINKING VARIANTS TO AF REMAIN ELUSIVE. GENETIC FINDINGS HAVE SO FAR FAILED TO YIELD CLINICALLY ACTIONABLE RESULTS. TO FILL THESE GAPS, WE SEEK TO GO BEYOND GWAS FINDINGS TO IDENTIFY DIRECT GENOMIC MECHANISMS UNDERLYING AF AND BETTER UNDERSTAND THEIR INTERACTIONS WITH ENVIRONMENT, COMORBIDITIES OR CELL STRESSORS. OUR LONG-TERM GOAL IS TO USE GENOMIC FINDINGS TO PERSONALIZE PREVENTIVE AND THERAPEUTIC STRATEGIES FOR AF. OUR OVERALL P01 THEME IS TO TRANSLATE AF GENETIC DISCOVERIES TOWARDS THE BEDSIDE, FOCUSING ON GENES TO MECHANISMS, GENES TO DRUGS, AND INTERACTIONS OF GENES WITH METABOLISM AND ENVIRONMENT. WE BUILD ON STRONG PRELIMINARY DATA AND COALESCE UNIQUE HUMAN ATRIAL TISSUE BIOREPOSITORY AND GENOMIC DATA RESOURCES, NOVEL CELL AND ANIMAL MODELS, AND COMPLEMENTARY EXPERTISE FROM OUR MULTIDISCIPLINARY TEAM WITH A STRONG COLLABORATION HISTORY. OUR CENTRAL HYPOTHESIS IS THAT GENOMIC MECHANISTIC DISCOVERIES IN AF CELLULAR AND ANIMAL MODELS WILL TRANSLATE TO HUMAN THERAPIES. OUR THEMATIC AIMS INCLUDE: 1) IDENTIFY CAUSAL GENES AND FUNCTIONAL MECHANISMS WITH A GOAL TOWARDS IDENTIFICATION OF NEW THERAPEUTIC APPROACHES FOR AF; 2) INVESTIGATE METABOLIC AND INFLAMMATORY MECHANISMS, IMPLICATED BY GENOMICS STUDIES TO BE IMPORTANT IN AF PATHOPHYSIOLOGY, TO IDENTIFY NEW THERAPEUTIC TARGETS FOR AF PREVENTION AND TREATMENT; AND 3) IDENTIFY CANDIDATE NOVEL DRUGS FOR AF AND DEVELOP A PIPELINE FOR IN VITRO AND IN VIVO FUNCTIONAL TESTING OF CANDIDATE THERAPIES. PROJECT 1 GENES TO FUNCTION WILL DETERMINE CAUSAL GENES, VARIANTS AND MECHANISMS UNDERLYING TWO AF GWAS LOCI. PROJECT 2 GENES AND METABOLISM WILL STUDY THE CONTRIBUTION OF MITOCHONDRIAL DYSFUNCTION TO AF ONSET AND PROGRESSION. EARLY STAGE INVESTIGATOR PROJECT GENES AND NUTRITION BUILDS ON NOVEL ASSOCIATIONS OF AF WITH TRIMETHYLAMINE N-OXIDE (TMAO), PRODUCED BY GUT MICROBIOTA FROM PRECURSORS SUCH AS CHOLINE FOUND IN EGGS, MEATS AND CHEESES. PROJECT 4 GENES TO OMICS-INFORMED DRUGS WILL IDENTIFY MECHANISMS AND REPURPOSABLE DRUGS TO PREVENT AF PROGRESSION. PROJECTS ARE SUPPORTED BY 4 CORES PROVIDING ADMINISTRATION, ENGINEERED HEART TISSUE AND ATRIAL PHENOTYPING, ELECTROPHYSIOLOGY, AND NETWORK AND SYSTEMS BIOLOGY ANALYTICS SUPPORT THAT SYNERGIZE DISCOVERY AND TRANSLATION IN AF AND INCREASE THE SCOPE AND IMPACT OF EACH PROJECT. ALL P01 COMPONENTS AIM TO BRIDGE BASIC RESEARCH IN AF TOWARDS CLINICAL UTILITY, THEREBY ADVANCING GENOMIC DATA AND RESEARCH TOWARDS THE BEDSIDE TO HELP OUR PATIENTS SUFFERING FROM ATRIAL FIBRILLATION.

2012 RAIL MODERNIZATION

2014 SOGR

MRN: MISSION OF DISCOVERY AND ADVANCEMENT OF CLINICAL SOLUTIONS FOR THE PREVENTION, DIAGNOSIS, AND TREATMENT OF MENTAL ILLNESS AND OTHER BRAIN DISOR

EMERGENCY SOLUTIONS GRANT PROGRAM

TO RAISE AND RECONSTRUCT DOCKS 24 AND 26 WEST AND REHABILIATE THE RAIL SPUR ADJACENT TO DOCK 24.

PA22FYPD PA20 T&TA

SELF REGULATING CONTINUOUS FLOW TOTAL ARTIFICIAL HEART

IDENTIFICATION OF THERAPEUTICS FOR THE TREATMENT OF SULFUR MUSTARD INJURY (U54)

GUT FLORA METABOLISM OF DIETARY PHOSPHATIDYLCHOLINE AND CARDIOVASCULAR DISEASE

IMPROVE EXISTING AIRPORT

HOME INVESTMENT PARTNERSHIPS PROGRAM

SEX-BASED DIFFERENCES IN GLIOMA

COPS HIRING RECOVERY PROGRAM

STATION REHABS (2) & TRACK UPGRADES

HEAD START

FY 2010 CAPITAL

FFY 2008 RAIL MODERNIZATION

IMPROVE EXISTING AIRPORT

HOMELESS PREVENTION & REHSNG

IMPROVE EXISTING AIRPORT

IMPROVE EXISTING AIRPORT

LEAD-BASED PAINT HAZARD CONTROL IN PRIVATELY-OWNED HOUSING

BIOLOGICAL BASES FOR RADIATION ADAPTIVE RESPONSES IN THE LUNG

RFA-IP-22-004, CORVETS - CLEVELAND OHIO RESPIRATORY VIRUSES VACCINES EFFECTIVENESS ACROSS TRADITIONAL RISK FACTORS AND SOCIAL DETERMINANTS OF HEALTH

FY2010 FIXED GUIDEWAY MODERNIZATION

NEURAL MECHANISM OF SCHIZOPHRENIA: USE OF MULTIPLE NEUROIMAGING TOOLS TO EXAMINE

NASH PROJECT

OXIDIZED PHOSPHOLIPIDS IN VASCULAR PATHOBIOLOGY

BUS REPLACEMENT PROGRAM

ALLIANCE OF RANDOMIZED TRIALS OF MEDICINE VS METABOLIC SURGERY IN TYPE 2 DIABETES - (ARMMS-T2D)

RISK AND RESILIENCE FACTORS FOR COMBAT-RELATED POSTTRAUMATIC PSYCHOPATHOLOGY AND POST COMBAT ADJUSTMENT

HEAD START

BUS REPLACEMENT PROGRAM

APPLICATION PURPOSE: THE PURPOSE OF THIS AWARD IS TO PROVIDE FUNDING FOR RECONSTRUCTION OF GCRTAS EAST 79TH STREET LIGHT RAIL (LR) STATION.; ACTIVITIES PERFORMED: THE EXISTING INFRASTRUCTURE WILL BE REPLACED WITH ADA-COMPLIANT PLATFORMS AND RAMPS WITH A CANOPY STRUCTURE TO PROTECT FROM INCLEMENT WEATHER.; EXPECTED OUTCOMES: THE STATION WILL BE ADA COMPLIANT WITH DESIGN FOCUSED ON A SAFE AND SECURE EXPERIENCE ACCESSIBLE TO ALL ITS CUSTOMERS.; INTENDED BENEFICIARIES: GCRTA CUSTOMERS ACCESSING LIGHT RAIL PARTICULARLY THOSE WITH MOBILITY ISSUES.; SUBRECIPIENT ACTIVITIES: N/A

CHP

REGULATION OF CNS VIRAL PERSISTENCE

HEALTH EFFECTS RESEARCH

CLEVELAND HEALTHY FAMILY/ HEALTHY START PROJECT

GENETIC AND CELLULAR DETERMINANTS OF ARTERIAL THROMBOSIS

2016 BUS REPLACEMENT PROGRAM

CARES ACT LEGISLATION ALLOCATION FOR SECTION 18004(A)(1) OF THE CARES ACT

THE IMPACT OF DIFFUSE MILD BRAIN INJURY ON CLINICAL OUTCOMES IN CHILDREN

HEMODIALYSIS FISTULA MATURATION CONSORTIUM DATA COORDINATING CENTER

TISSUE INJURY AND INFLAMMATION IN MULTIPLE SCLEROSIS

MOLECULAR DISSECTION OF CYTOKINE CROSSTALK IN THE TUMOR MICROENVIRONMENT - PROJECT SUMMARY DESPITE RECOGNITION OF THE BROAD CONSEQUENCES OF INFLAMMATION IN CANCER BIOLOGY, THE MECHANISTIC IMPACT ON THE TUMOR LANDSCAPE REMAINS INCOMPLETELY UNDERSTOOD. INDEED, INNATE AND ADAPTIVE IMMUNE FUNCTIONS IN CANCER CAN BE BENEFICIAL OR DETRIMENTAL AND THE OPPOSING ROLES HIGHLIGHT THE GAP OF KNOWLEDGE IN OUR UNDERSTANDING OF HOW INFLAMMATION SCULPTS THE TUMOR MICROENVIRONMENT (TME). THIS PROGRAM PROJECT WILL ADDRESS THIS GAP OF KNOWLEDGE BY DEFINING AND DELINEATING HOW CYTOKINES MODULATE THE FUNCTIONS OF THE MULTIPLE CELL TYPES COMPOSING THE TUMOR MICROENVIRONMENT. OUR PREVIOUS WORK HAS REVEALED THE POTENTIAL FOR THESE INFLAMMATORY CYTOKINES TO REGULATE A SPECTRUM OF CANCER CELL PHENOTYPES, INCLUDING THEIR SELF-RENEWAL AND CELLULAR HIERARCHY OR STEMNESS, THAT ARE ASSOCIATED WITH THE EPITHELIAL-MESENCHYMAL TRANSITION (EMT). MOREOVER, THESE PHENOTYPES ARE COMMONLY ASSOCIATED WITH CANCER PROGRESSION THROUGH MODULATION OF DIFFERENTIATION POTENTIAL, CELL-CELL INTERACTIONS AND MOBILITY, FIBROSIS, AND SENSITIVITY TO MULTIPLE THERAPEUTIC MODALITIES. THE PROGRAM IS NOW CENTERED ON TWO MAJOR THEMES. THE FIRST IS TO DEFINE THE SIGNALING MECHANISMS THAT GOVERN HOW CYTOKINES (TYPE I IFNS, IL- 17,TGFSS) MODULATE (BOTH POSITIVELY AND NEGATIVELY) THE EMT PROCESS. THE CELLULAR TARGETS INCLUDE STEM-LIKE TUMOR CELLS AS WELL AS THE NON-TUMOR DERIVED POPULATIONS, INCLUDING FIBROBLASTS AND IMMUNE CELLS. THE SECOND THEME RELATES THESE CELL-SPECIFIC EMT RESPONSES TO SPECIFIC EFFECTS ON METASTASIS, FIBROSIS, AND RESISTANCE TO MULTIPLE THERAPEUTIC STRATEGIES. OUR MAJOR GOAL IS TO PARLAY OUR IMPROVED UNDERSTANDING OF CYTOKINE EFFECTS IN THE TME INTO SPECIFIC IMPROVEMENTS IN CANCER THERAPY. COLLECTIVELY THE THREE PROJECTS IN THE APPLICATION WILL TEST THE FOLLOWING OVERARCHING HYPOTHESIS: CYTOKINE SIGNALS HAVE DISTINCT AND SOMETIMES CONFLICTING MECHANISTIC ROLES IN CANCER PROGRESSION THOUGH ALTERATIONS IN EMT AND CANCER STEM CELL DEVELOPMENT. SUCH MECHANISMS LEAD TO CRITICAL PHENOTYPIC PROPERTIES RESPONSIBLE FOR CONTINUOUS METASTATIC SPREAD AND RESISTANCE TO MULTIPLE THERAPEUTIC MODALITIES (CHEMOTHERAPY, IMMUNE THERAPY). THIS HYPOTHESIS WILL BE TESTED BY (1) DEFINING THE SIGNALING EVENTS INITIATED BY TGFSS, IL-17, AND/OR TYPE I IFNS AND THE ENDPOINT CHANGES IN SPECIFIC GENE EXPRESSION THAT ARE CAUSALLY LINKED WITH CONTROL OF TME AND CANCER CELL PHENOTYPES, (2) DETERMINATION OF HOW THESE SPECIFIC SIGNALING PATHWAYS AND GENE EXPRESSION EVENTS ARE MECHANISTICALLY RESPONSIBLE FOR ACQUISITION OF THERAPEUTIC RESISTANCE AND (3) EVALUATION OF THE DISTINCT CELL TYPE CONTRIBUTIONS TO TUMOR PHENOTYPES AND THERAPEUTIC RESISTANCE, WITH EMPHASIS ON TUMOR CELL INTRINSIC MECHANISMS, IMMUNE CELL INFILTRATES AND ACTIVITIES, AND STROMAL CELL CONTROL OF TUMOR ACCESS.

PROGNOSIS AND PREDICTORS OF ACL RECONSTRUCTION: A MULTICENTER COHORT STUDY

CYCLE-AD: RANDOMIZED CONTROLLED TRIAL TO ASSESS THE EFFICACY OF INDOOR CYCLING IN SLOWING DISEASE PROGRESSION IN HEALTHY OLDER PERSONS AT GENETIC RISK FOR ALZHEIMER?S DISEASE - PROJECT SUMMARY/ABSTRACT THE APOLIPOPROTEIN E EPSILON 4 (APOE 4) ALLELE IS THE MOST IMPORTANT GENETIC RISK FACTOR FOR LATE ONSET ALZHEIMER'S DISEASE (AD). A RECENT REVIEW BY THE WORLD HEALTH ORGANIZATION HIGHLIGHTED THE POTENTIAL PROTECTIVE ROLE OF PHYSICAL ACTIVITY AND EXERCISE AGAINST COGNITIVE DECLINE, ALL-CAUSE DEMENTIA, AD, AND VASCULAR DEMENTIA IN HEALTHY INDIVIDUALS. IN AN 18-MONTH LONGITUDINAL OBSERVATIONAL STUDY, WE SHOWED THAT SEDENTARY 4 CARRIERS EXPERIENCE SIGNIFICANT DECLINES IN EPISODIC MEMORY AND HIPPOCAMPAL VOLUME COMPARED TO 4 CARRIERS WHO ENGAGED IN MODERATE PA. IMPORTANTLY, AMONG 4 NON-CARRIERS, NO SIGNIFICANT LONGITUDINAL CHANGES IN COGNITION AND BRAIN IMAGING WERE OBSERVED WHETHER THE NON-CARRIERS WERE SEDENTARY OR ENGAGED IN MODERATE PA, SUGGESTING THAT PA HAS A SPECIFIC NEUROPROTECTIVE ROLE IN DELAYING THE PROGRESSION OF AD IN 4 CARRIERS. BASED ON OUR RESULTS, A PRAGMATIC, RANDOMIZED CONTROLLED TRIAL WITH BLINDED CLINICAL AND IMAGING OUTCOMES IS PROPOSED TO DETERMINE THE IMPACT OF A HOME BASED, HIGH INTENSITY EXERCISE INTERVENTION IN HEALTHY, COGNITIVELY INTACT 4 CARRIERS BETWEEN THE AGES OF 65 AND 80 YEARS. THE CYCLE-AD (CYCLING TO CEASE OR LIMIT THE EFFECTS OF ALZHEIMER'S DISEASE) TRIAL WILL RECRUIT OTHERWISE HEALTHY SEDENTARY CARRIERS RANDOMIZED TO ONE OF TWO GROUPS (N=75 EACH): 1) AN INDOOR CYCLING (IC) GROUP THAT PARTICIPATES IN HIGH-INTENSITY INTERVAL TRAINING (HIIT; 60-90% OF HEART RATE RESERVE) IN THEIR HOME VIA THE COMMERCIALLY AVAILABLE PELOTON® CYCLING SYSTEM OR 2) A USUAL AND CUSTOMARY CARE (UCC) GROUP, IN WHICH PARTICIPANTS ENGAGE IN THEIR HABITUAL LEVEL OF PA. WE HYPOTHESIZE THAT AN 18-MONTH HIGH-INTENSITY AEROBIC EXERCISE REGIMEN WILL SLOW AD-RELATED DISEASE PROGRESSION IN SEDENTARY ELDERS AT GENETIC RISK FOR AD. PARTICIPANTS IN THE INTERVENTION GROUP WILL ENGAGE IN EXERCISE 3X/WEEK (MINIMUM 90 MINUTES/WEEK) FOR 18 MONTHS. PRIMARY OUTCOME MEASURES, OBTAINED AT STUDY ENTRY AND AT 18 MONTHS, WILL INCLUDE COMPREHENSIVE COGNITIVE TESTING AND BRAIN MR IMAGING TO ASSESS DISEASE PROGRESSION AND A COMPREHENSIVE PA/FITNESS ASSESSMENT TO MEASURE THE DEGREE OF CHANGE IN PHYSICAL FITNESS DUE TO HIGH INTENSITY AEROBIC EXERCISE. THE OVERALL GOAL OF THE CYCLE-AD TRIAL IS TO DETERMINE THE ROLE OF LONG-TERM, HIGH INTENSITY EXERCISE IN SLOWING OR DELAYING THE ONSET OF COGNITIVE AND AD-RELATED BRAIN CHANGES IN 4 CARRIERS. SUCCESSFUL TRANSLATION AND DEMONSTRATION OF THE EFFECTIVENESS OF A SCALABLE HOME-BASED EXERCISE INTERVENTION CAPABLE OF SLOWING OR DELAYING DISEASE ONSET WILL TRANSFORM AD TREATMENT, IMPROVE PATIENT OUTCOMES AND QUALITY OF LIFE, AND REDUCE HEALTH CARE COSTS.

POST-TRANSPLANT INFLAMMATORY RESPONSE

IMPROVE EXISTING AIRPORT

GCRTA IS REQUESTING $3287229 IN FY 2019 2020 FHWA CMAQ FUNDING THROUGH THE OHIO DEPARTMENT OF TRANSPORTATION (ODOT) DIESEL EMISSIONS REDUCTION GRANT (DERG) PROGRAM TO SUPPORT ITS BUS IMPROVEMENT PROGRAM AS FOLLOWS:1)$1643099 FY 2019 WITH A LOCAL SHARE OF $809237 (33%) FOR A TOTAL OF $2452385; LOCAL SHARE IS COMPRISED OF SALES TAX2)$1644131 FY 2020 WITH A LOCAL SHARE OF $809796 (33%) FOR A TOTAL OF $2453927; LOCAL SHARE IS COMPRISED OF SALES TAXPURPOSE: PURCHASE REPLACEMENT CNG-FUELED VEHICLESACTIVITIES TO BE PERFORMED: REPLACE EXISTING DIESEL-FUELED VEHICLES WHICH HAVE REACHED THE END OF THEIR USEFUL LIVES WITH CNG-FUELED VEHICLESEXPECTED OUTCOMES: CNG-FUELED VEHICLES WILL INCREASE AIR QUALITY WHILE NEW VEHICLES ENSURE A SAFE AND RELIABLE TRANSIT SYSTEMINTENDED BENEFICIARIES: GCRTAS CUSTOMERS AND THE RESIDENTS OF CUYAHOGA COUNTY.SUBRECIPIENT ACTIVITIES: N/AATTACHMENTS INCLUDE: 1)2018-2021 DOT/FTA STIP APPROVAL LETTER 6-27-17 ODOT 2018-2021 STIP STATEWIDE LINE ITEM (SLI) GROUPED PROJECT LIST APPENDIX 5 ODOT 2018-2021 STIP SLI GROUPED PROJECT REPORT AS OF 12-6-19 PID 106792 PAGE 387 OF 589 ODOT CMAQ TRANSFER MEMO 1-25-19 NOACA EMAIL 6-30-212)2021-2024 FTA/DOT STIP APPROVAL LETTER 10-2-20 ODOT FY 2021 - 2024 STIP AMENDMENT # 1 PROJECT LIST (PAGE 9 OF 12) PID # 112317 PAGE 9 OF 12 ODOT CMAQ TRANSFER MEMO 12-22-203)2019 2020 OHIO EPA DERG AWARD LETTERS DATED 12-31-18 AND 1-24-20 GCRTAS 2021 4TH QTR BUS IMPROVEMENT PLAN DERG FLEET DATA WORKSHEET - FY 2019 2020 GCRTA 2022-2026 CAPITAL IMPROVEMENT BUDGET

CENTRAL VEIN SIGN: A DIAGNOSTIC BIOMARKER IN MULTIPLE SCLEROSIS

THE NEW MEXICO HEALTH INFORMATION COLLABORATIVE (NMHIC) STATEWIDE HIE EXPANSION PROJECT NMHIC, THE NEW MEXICO SDE, IS O

MOLECULAR BASIS OF ILK SIGNALING IN CELL ADHESION

TOWARDS PRECISION IMMUNO-ONCOLOGY: UNRAVELING THE GENOMIC DETERMINANTS AND MECHANISMS UNDERLYING IMMUNOTHERAPY EFFICACY AND RESISTANCE

NEI CENTER CORE GRANT FOR VISION RESEARCH

PHASE III COBRE: MULTIMODAL IMAGING OF NEUROPSYCHIATRIC DISORDERS (MIND)

PATHOGENESIS OF NEUROLOGICAL DISABILITY IN PRIMARY DISEASES OF MYELIN

MOLECULAR DETERMINANTS OF CORONARY ARTERY DISEASE

COMMUNITY DEVELOPMENT BLOCK GRANTS/ENTITLEMENT GRANTS

HOME INVESTMENT CPD

HOME INVESTMENT CPD

IMPROVE EXISTING AIRPORT

CLEVELAND CLINIC CARDIOTHORACIC COLLABORATIVE CLINICAL CENTER (C6)

NEW MEXICO REGIONAL CENTER

BRUNSWICK BUSES AND OPER ASSIST

CITIES RECOVERY

GENOMIC AND MICROENVIRONMENTAL DETERMINANTS, TEMPORAL DYNAMICS, AND TREATMENT EFFICACY OF RADIATION-BASED COMBINATION THERAPIES - PROJECT SUMMARY OVERALL SECTION OUR ROBIN CENTER FOCUSES ON ELUCIDATING THE GENOMIC AND MICROENVIRONMENTAL DETERMINANTS, AND TEMPORAL DYNAMICS UNDERLYING EFFICACY OF RADIATION-BASED COMBINATION THERAPIES. RADIOTHERAPY (RT), ALONE OR IN COMBINATION WITH OTHER TREATMENTS, IS USED TO TREAT ABOUT TWO-THIRDS OF ALL CANCER PATIENTS. DESPITE THE WIDESPREAD USE OF RADIATION THERAPY IN ONCOLOGY, OUR UNDERSTANDING OF THE MECHANISMS DRIVING RESPONSE AND RESISTANCE REMAINS POOR. OUR LONG-TERM GOAL IS TO UNDERSTAND THE MECHANISMS THAT UNDERLIE EFFICACY AND RESISTANCE OF RADIATION-BASED THERAPIES. NEW EFFORTS TO IMPROVE TREATMENT FOR MANY CANCER TYPES NOW FOCUS ON USING COMBINATION THERAPIES IN WHICH RADIATION IS USED WITH SYSTEMIC AGENTS, HIGHLIGHTING THE URGENT NEED TO UNDERSTAND THE DRIVERS OF EFFICACY. AMONG THE MOST PROMISING NEW BIOLOGICS BEING STUDIED FOR USE WITH RADIATION ARE ANTIBODY-DRUG CONJUGATES (ADC) AND IMMUNE CHECKPOINT INHIBITORS (ICI). WE WILL USE AN INNOVATIVE MOLECULAR CHARACTERIZATION TRIAL TESTING RADIATION PLUS ADC IN BLADDER CANCER AND RADIATION PLUS ICI IN HEAD AND NECK CANCER TO CHARACTERIZE THE MECHANISTIC DRIVERS UNDERLYING THESE NEXT GENERATION RT-BASED COMBINATIONS. THE CENTRAL HYPOTHESIS OF THIS U54 APPLICATION IS THAT SPECIFIC GENETIC AND IMMUNOLOGIC MECHANISMS UNDERLIE SENSITIVITY AND RESISTANCE TO RADIATION-BASED COMBINATION THERAPIES. WE WILL ADDRESS THESE QUESTIONS THROUGH 3 SPECIFIC AIMS. IN AIM 1, WE WILL WORK TO UNDERSTAND THE MOLECULAR MECHANISMS THAT UNDERLIE EFFICACY OF TREATMENT WITH RADIATION PLUS ADC. HERE, OUR WORKING HYPOTHESIS IS THAT SPECIFIC GENETIC AND IMMUNOLOGIC EVENTS UNDERLIE RESPONSE TO RT PLUS SACITUZUMAB GOVITECAN (SG) TREATMENT. WE WILL LEVERAGE OUR MOLECULAR CHARACTERIZATION TRIAL (PART A) INVESTIGATING THE USE OF RT AND SACITUZUMAB FOR BLADDER PRESERVATION THERAPY. WE WILL DETERMINE THE DIFFERENTIAL MOLECULAR EFFECTS WITH STANDARD-OF-CARE RT + CISPLATIN VERSUS RT + SG. IN AIM 2, WE WILL IMPROVE IDENTIFICATION OF PATIENTS WHO ARE SENSITIVE OR RESISTANT TO RT-BASED THERAPIES BASED ON NEW INSIGHTS INTO TRANSCRIPTIONAL DYNAMICS AND TEMPORAL REPROGRAMMING DURING TREATMENT WITH RADIATION-BASED THERAPIES. HERE, WE WILL LEVERAGE OUR MOLECULAR CHARACTERIZATION TRIAL TREATING HEAD AND NECK SQUAMOUS CELL CARCINOMA (HNSCC) OR BLADDER CANCER PATIENTS WITH RT + CHEMOTHERAPY VERSUS RT + SG OR ICI. WE WILL BUILD ON RECENT EXPERIMENTAL AND CLINICAL BREAKTHROUGHS LED BY OUR RESEARCH GROUPS, WHICH HAVE IDENTIFIED HIGHLY REFINED GENE EXPRESSION PROGRAMS ASSOCIATED WITH RT SENSITIVITY AND DELTA RADIOMICS. IN AIM 3, WE WILL IDENTIFY THE DIFFERENTIAL MECHANISMS UNDERLYING THE ANTI-TUMOR ACTIVITIES OF RT + CISPLATIN VERSUS RT + IMMUNE CHECKPOINT BLOCKADE. HERE, USING OUR HEAD AND NECK TRIAL (PART B), WE WILL UNCOVER THE UNIQUE GENETIC AND IMMUNOLOGIC FACTORS THAT GOVERN RESPONSE TO RT WHEN COMBINED WITH THESE TWO CLASSES OF AGENTS. WE WILL ELUCIDATE THE DIFFERENTIAL MOLECULAR EFFECTS OF THE TWO APPROACHES, IMMUNE REPROGRAMMING, AND MECHANISMS OF ACQUIRED RESISTANCE. OUR STUDIES WILL HELP BUILD A FOUNDATION TO OPTIMIZE MULTIMODAL, RADIATION- BASED DEFINITIVE TREATMENT STRATEGIES.

MAGNET SCHOOLS ASSISTANCE

MOLECULAR BASIS OF KSHV ONCOGENESIS

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CARE-ING COMMUNITIES, THEATRE AND RESILIENCE

FUNCTIONAL GENOMICS OF ATRIAL FIBRILLATION IN HUMAN ATRIA

BEAR-MOON: A TWO ARM NONINFERIORITY BLINDED RANDOMIZED CLINICAL TRIAL COMPARING ACL REPAIR WITH BEAR DEVICE VS. STANDARD OF CARE AUTOGRAFT PATELLAR TENDON ACL RECONSTRUCTION

RANDOMIZED TRIAL OF ASSISTED AMBULATION TO IMPROVE HEALTH OUTCOMES FOR OLDER MEDICAL INPATIENTS - PROJECT SUMMARY/ABSTRACT FOR OLDER ADULTS, PROLONGED HOSPITALIZATION CAN LEAD TO A DEVASTATING LOSS OF MOBILITY AND INDEPENDENCE. EACH YEAR, 12 MILLION ADULTS OVER THE AGE OF 65 ARE HOSPITALIZED, AND 30% ARE DISCHARGED TO A POST-ACUTE CARE FACILITY. ONE OF THE RISKS OF HOSPITALIZATION IS BED REST, WHICH IS ASSOCIATED WITH A NUMBER OF HOSPITAL-ACQUIRED COMPLICATIONS, INCLUDING FALLS, DELIRIUM, VENOUS THROMBOSIS AND SKIN BREAKDOWN. HOSPITAL MOBILITY PROGRAMS ATTEMPT TO AMBULATE PATIENTS UP TO THREE TIMES DAILY, BUT THIS WORK IS GENERALLY ASSIGNED TO NURSES, WHO HAVE MANY COMPETING AND OFTEN MORE PRESSING TASKS. CONSEQUENTLY, AMBULATING PATIENTS IS THE MOST FREQUENTLY OVERLOOKED NURSING DUTY. THIS PROBLEM HAS BEEN EXACERBATED BY THE COVID-19 PANDEMIC AND THE RESULTING NURSING SHORTAGE. SMALL STUDIES HAVE EXAMINED THE BENEFITS OF MOBILITY TECHNICIANS (MTS), WHOSE SOLE JOB IS TO SAFELY AMBULATE PATIENTS. THESE STUDIES HAVE DEMONSTRATED THAT MTS CAN INCREASE STEPS TAKEN, BUT THEY ARE TOO SMALL TO PROVE THE IMPACT OF MTS ON OTHER OUTCOMES, SUCH AS WHETHER PATIENTS HAVE IN-HOSPITAL COMPLICATIONS OR WHETHER THEY CAN GO HOME INSTEAD OF TO A POST-ACUTE CARE FACILITY. HOSPITALS ARE HESITANT TO ADOPT MT PROGRAMS BECAUSE THEY PERCEIVE THEM TO BE EXPENSIVE AND UNPROVEN. WE PROPOSE TO CONDUCT A LARGE RANDOMIZED TRIAL TO TEST THE IMPACT OF MTS ON SHORT AND INTERMEDIATE TERM OUTCOMES FOR 3000 PATIENTS AGED 65 YEARS AND OLDER AT 5 HOSPITALS IN 2 HEALTH SYSTEMS. PATIENTS WILL BE RANDOMIZED TO RECEIVE SUPERVISED AMBULATION UP TO 3 TIMES DAILY WITH A MT OR TO RECEIVE USUAL CARE. ALL PARTICIPANTS WILL WEAR AN ACCELEROMETER ON THEIR WRIST TO TRACK THEIR MOVEMENT THROUGHOUT THE HOSPITAL STAY. THE STUDY HAS 3 AIMS. FIRST, WE WILL COMPARE THE MOBILITY OF PATIENTS AT DISCHARGE (OR 10 DAYS) TO ASSESS THE IMPACT OF THE MTS ON THIS OUTCOME. WE ARE PARTICULARLY INTERESTED IN WHETHER THE USE OF MTS WILL INCREASE THE PROPORTION OF PATIENTS WHO CAN GO HOME VS. POST-ACUTE CARE, AND WHETHER THE IMPROVEMENTS IN MOBILITY ARE SUSTAINED AT 30 DAYS. SECOND, WE WILL USE PREDICTIVE MODELING TO IDENTIFY WHICH PATIENTS ARE MOST LIKELY TO BENEFIT FROM THIS INTERVENTION. THIRD, WE WILL ASSESS THE IMPACT OF THE INTERVENTION ON OVERALL COSTS ASSOCIATED WITH THE EPISODE OF CARE, INCLUDING INPATIENT COSTS AND THE 30 DAYS AFTER DISCHARGE. THIS INFORMATION WILL BE IMPORTANT TO CONVINCE HEALTH SYSTEMS TO ADOPT THIS APPROACH.

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FY 2006 BUS DISC INCL SUBRECIPIENTS

ENSURING PATIENTS' INFORMED ACCESS TO NONINVASIVE PRENATAL TESTING

ACTIVATION OF BLOOD AND ENDOTHELIAL CELL A5B3 INTEGRIN

AWARD PURPOSE THE PURPOSE OF THIS PROGRAM IS TO CREATE EQUITY IN REGISTERED APPRENTICESHIP PROGRAMS HUB (E-RAP). ACTIVITIES PERFORMED TWO PROGRAM GOALS ARE IMPLEMENTED IN THE SCOPE OF WORK: PROGRAM GOAL #1: ESTABLISH A MULTIFUNCTIONAL RAP HUB; PROGRAM GOAL #2: BECOME A STATEWIDE RESOURCE TO EXPAND EQUITABLE RAP IMPLEMENTATION SERVING UNDERREPRESENTED COMMUNITIES. PROGRAM ACTIVITIES INCLUDE: (1) CENTRALIZED CROSS-INDUSTRY RESOURCE CENTER, (2) ROBUST EMPLOYER ENGAGEMENT, (3) INCENTIVE FUNDING, (4) EMPLOYER TECHNICAL ASSISTANCE LEADING TO RAP ADOPTION, (5) NETWORK OF EQUITY-FOCUSED PARTNERS, AND (6) AN EXPANSION COHORT SUPPORTING STATEWIDE SCALING INITIATIVES. DELIVERABLES 800 (80% FROM UNDERREPRESENTED GROUPS) INTENDED BENEFICIARY UN-AND-UNDEREMPLOYED; WOMEN, PEOPLE OF COLOR, VETERANS. SUBRECIPIENT ACTIVITIES PARTNERS ASSEMBLED TO SUPPORT THE DELIVERY OF THIS SCOPE OF WORK WITH ROLES FOR: (1) EMPLOYER ENGAGEMENT, (2) PROVISION OF RAP TECHNICAL ASSISTANCE, (3) RELATED INSTRUCTION, (4) PRE-APPRENTICESHIP; AND APPRENTICESHIP RECRUITMENT AND SUPPORT, AND (5) EXPANSION.

BUS CMAQ HEALTHLINE OPER. EXPENSES

LEAD-BASED PAINT HAZARD CONTROL IN PRIVATELY-OWNED HOUSING

CONNECTING CLEVELAND PROJECT

CONNECTING CLEVELAND PROJECT

PRE-, PERI-, AND POST-DEPLOYMENT TRAJECTORIES AND MECHANISMS OF PSYCHOPATHOLOGY, PSYCHOLOGICAL HEALTH, AND RESILIENCE OVER 9 YEARS OF PROSPECTIVE FOL

CHILDREN'S HOSPITALS GRADUATE MEDICAL EDUCATION PAYMENT PROGRAM

DEFINING THE VIRAL PTMOME: TOWARDS THE DEVELOPMENT OF NOVEL ANTIVIRAL APPROACHES - PROJECT SUMMARY OVER THE PAST SEVERAL DECADES, THE TRADITIONAL APPROACH TO COMBATING VIRAL INFECTIOUS DISEASES HAS BEEN TO TARGET THE VIRUS ITSELF, IN MOST CASES BY EITHER BLOCKING VIRUS-ENCODED ENZYMES THAT ARE REQUIRED FOR VIRAL REPLICATION, OR BY PREVENTING THE VIRUS FROM ENTERING HOST CELLS. ONE OF THE MAJOR CAVEATS OF THESE APPROACHES HAS BEEN THE ABILITY OF THE VIRUS TO READILY MUTATE AND THEREBY BECOME RESISTANT TO THESE CLASSICAL TYPES OF ANTIVIRAL THERAPIES. IN FACT, THIS IS A SERIOUS PROBLEM FOR THE THERAPY OF RNA VIRUS INFECTIONS, SUCH AS HIV OR INFLUENZA VIRUS, WHICH ARE KNOWN TO RAPIDLY MUTATE AND THEREBY ESCAPE ANTIVIRAL DRUGS. ADDITIONALLY, TRADITIONAL ANTIVIRAL APPROACHES ARE DESIGNED TO TARGET A SPECIFIC VIRUS, AND THEREFORE ARE INEFFECTIVE AGAINST ANY NEW VIRUS THAT MAY EMERGE IN THE FUTURE, AND IT IS IMPOSSIBLE TO PREDICT WHAT VIRUS WILL CAUSE THE NEXT OUTBREAK OR PANDEMIC. THEREFORE, THERE IS THE URGENT NEED TO DEVELOP NEW WAYS FOR TARGETING VIRAL PATHOGENS, WHICH WILL REQUIRE CREATIVE AND INNOVATIVE RESEARCH. LIKE HUMAN PROTEINS, VIRAL PROTEINS ROBUSTLY UNDERGO POSTTRANSLATIONAL MODIFICATIONS (PTMS) FOR THEIR REGULATION AND PROPER FUNCTIONING IN THE VIRUS LIFE CYCLE. IN MOST CASES, VIRAL PTMS ARE DYNAMICALLY REGULATED BY HUMAN ENZYMES, SUCH AS KINASES/PHOSPHATASES, UBIQUITIN E3 LIGASES/DEUBIQUITINATING ENZYMES, OR ACETYL TRANSFERASES/DEACETYLASES. THUS, CELLULAR ENZYMES PLAY AN IMPORTANT ROLE IN CONTROLLING THE ABILITY OF THE VIRUS TO REPLICATE AND TO CAUSE DISEASE. THIS PROPOSAL’S OVERARCHING GOAL IS TO COMPREHENSIVELY MAP THE ‘VIRAL PTMOME’ TO IDENTIFY THE PTMS THAT ARE ESSENTIAL FOR VIRUS REPLICATION AND PATHOGENESIS. WE WILL COMBINE PROTEOMICS SCREENS AND MOLECULAR VIROLOGY APPROACHES INCLUDING REVERSE GENETICS TECHNIQUES WITH CUTTING- EDGE MOLECULAR, BIOCHEMICAL AND BIOPHYSICAL STUDIES. THIS WILL ALLOW US TO IDENTIFY AND CHARACTERIZE VIRAL PTMS AND THE RESPONSIBLE HOST MODIFYING ENZYMES, AS WELL AS TO DETERMINE THEIR ROLES FOR EFFECTIVE VIRAL REPLICATION AND PATHOGENESIS. THIS POWERFUL APPROACH, COMBINED WITH COLLABORATIVE STUDIES TO DESIGN AND TEST CHEMICAL INHIBITORS TO BLOCK THE ENZYMES THAT REGULATE CRITICAL VIRAL PTMS, WILL NOT ONLY PROVIDE UNIQUE MECHANISTIC INSIGHT INTO HOST CONTROL OF VIRUS REPLICATION BUT WILL ALSO LAY THE GROUNDWORK FOR DEVELOPING NEW ANTIVIRALS FOR A RANGE OF EMERGING VIRAL INFECTIOUS DISEASES.

CARES ACT LEGISLATION ALLOCATION FOR SECTION 18004(A)(1) OF THE CARES ACT

ACTIVATION OF THE BETA-3 INTEGRINS: ROLE OF THE KINDLINS

RYAN WHITE PART C OUTPATIENT EIS PROGRAM