How

ACADEMIC

ACADEMIC

ACADEMIC

HOWARD UNIVERSITY (ACADEMIC)

UNKNOWN TITLE

HOWARD UNIVERSITY (ACADEMIC)

HOWARD UNIVERSITY (ACADEMIC)

HOWARD UNIVERSITY (ACADEMIC)

HOWARD UNIVERSITY (ACADEMIC)

HOWARD UNIVERSITY ACADEMIC

HOWARD UNIVERSITY RESEARCH CENTER FOR MINORITY HEALTH AND HEALTH DISPARITIES

HOSPITAL

HOSPITAL

HOSPITAL

HIGHER EDUCATION EMERGENCY RELIEF FUND FORMULA GRANTS AUTHORIZED BY SECTION 18004(A)(1) OF THE CARES ACT

HOWARD UNIVERSITY (HOSPITAL)

UNKNOWN TITLE

HOWARD UNIVERSITY (HOSPITAL)

HOWARD UNIVERSITY (HOSPITAL)

HOWARD UNIVERSITY (HOSPITAL)

CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND IHE CFDA: 84-425E

HOWARD UNIVERSITY (HOSPITAL)

NOAA COOPERATIVE SCIENCE CENTER IN ATMOSPHERIC SCIENCES AND METEOROLOGY AT HOWARD UNIVERSITY

HOWARD COMMUNITY COLLEGE - INSTITUTIONAL PORTION OF THE HIGHER EDUCATION EMERGENCY RELIEF FUND FORMULA GRANTS

HEALTH CENTER CLUSTER

THE NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION (NOAA) AWARD RECIPIENT IS THE HOWARD UNIVERSITY. THIS NOAA OFFICE OF EDUCATION, EDUCATIONAL PARTNERSHIP PROGRAM WITH MINORITY SERVING INSTITUTIONS ((EPP/MSI) COOPERATIVE SCIENCE CENTER (CSC) FOCUSES ON ATMOSPHERIC SCIENCES AND METEOROLOGY THAT ALIGNS WITH THE NOAA MISSION. THE ACADEMIC HOME OF THE CENTER IS THE GRADUATE SCHOOL AT HOWARD UNIVERSITY. THE PURPOSE IS TO ENHANCE DEVELOPING STUDENTS THROUGH EDUCATION, AND WITH INTERNSHIPS AT NOAA, TO BE A DIVERSE CADRE OF NEW PROFESSIONALS, REPRESENTATIVE OF THE NATIONS DEMOGRAPHY, AND ELIGIBLE CANDIDATES FOR THE FUTURE NOAA MISSION ENTERPRISE WORKFORCE. THIS IS THE SECOND FIVE-YEAR AWARD CYCLE FOR THE NOAA CENTER FOR ATMOSPHERIC SCIENCES AND METEOROLOGY (NCAS-M II) FUNDED ANNUALLY, BASED ON SATISFACTORY PERFORMANCE, CONTINUED ALIGNMENT WITH NOAA MISSION AND FEDERAL APPROPRIATIONS. THE AWARD HAS A FUNDING MAXIMUM OF UP TO $30M. THE PERFORMING PERIOD IS SEPTEMBER 1, 2022 - AUGUST 31, 202

HEALTH CENTER CLUSTER

COMPUTATIONAL BIOLOGY, BIOINFORMATICS, IMAGING & PROTEOMICS RESEARCH-RCMI

THE NOAA CENTER FOR ATMOSPHERIC SCIENCES AT HOWARD UNIVERSITY

HOWARD COMMUNITY COLLEGE - EMERGENCY FINANCIAL AID GRANTS TO STUDENTS UNDER THE CARES ACT

SUPPORTING THE SCALE-UP OF HIGH QUALITY HIV CARE AND TREATMENT PROGRAMS IN

HEAD START PROGRAM

HEAD START

WASHINGTON DC-BALTIMORE RESEARCH CENTER ON CHILD HEALTH DISPARITIES

NOAA CENTER FOR ATMOSPHERIC SCIENCES AT HOWARD UNIVERSITY

HEALTH CENTER PROGRAM

HEAD START

PRH/RTU -- DTC #1.

BIOMEDICAL IMAGING AND MOLECULAR STRUCTURAL STUDIES-RCMI

NATIONAL MENTORING REPLICATION

USAID WILL PROVIDE 15 FELLOWSHIPS TO OUTSTANDING CANDIDATES FROM UNDERREPRESENTED RACIAL AND ETHNIC GROUPS, HISTORICALLY MARGINALIZED POPULATIONS AND THOSE FROM SOCIOECONOMICALLY DISADVANTAGED BACKGROUNDS IN THE UNITED STATES, AND WHO HAVE AN INTEREST IN PURSUING A FOREIGN SERVICE CAREER WITH USAID. THE RECIPIENT SHALL PROVIDE FUNDING TO ASSIST THESE STUDENTS TOWARD COMPLETING A FULL-TIME TWO-YEAR GRADUATE DEGREE IN ACADEMIC DISCIPLINES REPRESENTING THE SKILL NEEDS OF USAID, AS WELL AS PROVIDING PROFESSIONAL DEVELOPMENT ACTIVITIES THROUGH ORIENTATION, SKILLS DEVELOPMENT ACTIVITIES, MENTORSHIP AND SUPPORT FOR SUMMER ROTATIONS/DETAILS IN WASHINGTON D.C. AND OVERSEAS AT A USAID MISSION.

HCAI@HU: BUILDING RESEARCH CAPACITY AND FUTURE ONR/DOD WORKFORCE SKILLS IN HUMAN-CENTERED ARTIFICIAL INTELLIGENCE AT HOWARD UNIVERSITY

RYAN WHITE PART C OUTPATIENT EIS PROGRAM

ENDOWMENT

HIGHER EDUCATION EMERGENCY RELIEF ACT - INSTITUTIONAL (CARES ACT)

CENTER OF EXCELLENCE IN ARTIFICIAL INTELLIGENCE AND MACHINE LEARNING (COE-AIML)

CENTERS OF EXCELLENCE

CENTER FOR HEMOGLOBIN RESEARCH IN MINORITIES (CHARM)

HOWARD UNIVERSITY HOSPITAL

INHIBITION OF HIV-1 IN SICKLE CELL DISEASE

COVID-19 INSTITUTION EMERGENCY SOLUTIONS PROJECT

AMERICAN RESCUE PLAN ACT FUNDING FOR HEALTH CENTERS

TO INCREASE THE REPRESENTATION OF DIVERSE GROUPS IN THE FOREIGN SERVICE.

DIVERSITY RECRUITMENT PROGRAM TO INCREASE THE REPRESENTATION OF DIVERSE GROUPS IN THE FOREIGN SERVICE.

TO RECRUIT DIVERSE TALENT FOR THE USG FOREIGN SERVICE.

TO RECRUIT AND DEVELOP NEW TALENT FOR THE DEPARTMENT OF STATE FOREIGN SERVICE

AFFORDABLE CARE ACT - CAPITAL DEVELOPMENT GRANTS

RYAN WHITE PART C OUTPATIENT EIS PROGRAM

EMERGENCY FINANCIAL AID GRANTS TO STUDENTS UNDER THE CORONAVIRUS ACT, RELIEF, & ECONOMIC SECURITY (CARES) ACT

TO INCREASING THE REPRESENTATION OF DIVERSE GROUPS IN THE FOREIGN SERVICE.

DIVERSITY RECRUITMENT PROGRAM TO INCREASE THE REPRESENTATION OF DIVERSE GROUPS IN THE U.S. FOREIGN SERVICE.

RECRUITMENT PROGRAM TO INCREASE THE REPRESENTATION OF DIVERSE GROUPS IN THE FOREIGN SERVICE. THIS IS THE FIRST INSTALLMENT

TO RECRUIT DIVERSE TALENT FOR THE USG FOREIGN SERVICE.

TO RECRUIT DIVERSE TALENT FOR THE USG FOREIGN SERVICE. THIS IS THE FIRST INSTALLMENT.

PURPOSE: RECONSTRUCT RUNWAY. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT RECONSTRUCTS 3,250 FEET OF EXISTING PAVED RUNWAY 12/30 THAT HAS REACHED THE END OF ITS USEFUL LIFE. THIS GRANT FUNDS A PORTION OF THE TOTAL PROJECT. THIS GRANT IS ASSOCIATED WITH AN AIRPORT INFRASTRUCTURE GRANT THAT FUNDS THE REMAINING ELIGIBLE PORTION OF THE PROJECT. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH CHOWCHILLA, CALIFORNIA.

RECRUITMENT PROGRAM TO INCREASE THE REPRESENTATION OF DIVERSE GROUPS IN THE FOREIGN SERVICE. THIS IS THE FIRST INSTALLMENT.

UNIVERSITY TRANSPORTATION CENTERS

DONALD PAYNE FELLOWSHIP PROGRAM

HOWARD UNIVERSITY CANCER CENTER/JOHNS HOPKINS CANCER CENTER PARTNERSHIP

EARLY HEAD START

HEALTH CENTER PROGRAM

DOMESTIC WATER GRANTS - REGULAR

EARLY HEAD START GRANT

RUN TO R1

EXPANDQISE: TRACK 2: A QUANTUM SCIENCE EDUCATION AND RESEARCH PROGRAM FOR HBCUS: EXOTIC PHYSICS AND APPLICATIONS OF SOLID-STATE QUBITS -NON-TECHNICAL DESCRIPTION: QUANTUM INFORMATION SCIENCE AND ENGINEERING (QISE) IS WIDELY RECOGNIZED AS A KEY DRIVER FOR REALIZING GAME-CHANGING SCIENTIFIC BREAKTHROUGHS AND TRANSFORMATIVE NEW QUANTUM COMPUTING, SENSING, AND COMMUNICATION TECHNOLOGIES FOR ENSURING NATIONAL SECURITY AND MAINTAINING THE ECONOMIC COMPETITIVENESS OF THE U.S. IT IS NECESSARY TO BUILD PARTNERSHIPS BETWEEN ACADEMIA, NATIONAL LABORATORIES, AND INDUSTRY IN ORDER TO EFFECTIVELY ADVANCE THE QISE FOREFRONT BY ENGAGING A DIVERSE WORKFORCE. HISTORICALLY BLACK COLLEGES AND UNIVERSITIES (HBCUS), HOWEVER, LACK THE NEEDED FACULTY STRENGTH AND LABORATORY INFRASTRUCTURE FOR QISE TRAINING OF STUDENTS. THIS FIVE-YEAR PROJECT AIMS TO FILL THIS CRITICAL GAP BY ESTABLISHING AN EXPANSIVE QISE RESEARCH AND TRAINING PROGRAM AT HOWARD UNIVERSITY (HU) IN CLOSE PARTNERSHIP WITH NORTHEASTERN UNIVERSITY, WHERE QUANTUM RESEARCH AND EDUCATION PROGRAMS ARE WELL-ESTABLISHED. COLLABORATING NATIONAL LABORATORIES AND INDUSTRIES ARE: NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY (NIST), NATIONAL RENEWABLE ENERGY LABORATORY (NREL), IBM, QUANTUM DESIGN, AND QNAMI. THE SCIENTIFIC FOCUS OF THE PROJECT IS ON MODELING, DISCOVERY, UNDERSTANDING, AND APPLICATIONS OF QUANTUM BITS OR QUBITS, WHICH ARE THE KEY COMPONENTS OF THE QISE ECOSYSTEM, MUCH AS THE CLASSICAL BITS UNDERLIE THE MODERN ELECTRONICS REVOLUTION. THIS EFFORT WILL ALSO PROVIDE A ROADMAP FOR OTHER HBCUS AND MINORITY SERVING INSTITUTIONS (MSIS) THROUGHOUT THE U.S. TO PROPEL THEMSELVES TOWARD LEADERSHIP ROLES IN QISE. TECHNICAL DESCRIPTION: THIS PROJECT IS PURSUING A VIBRANT QISE RESEARCH AND TRAINING PROGRAM AT HU IN CLOSE PARTNERSHIP WITH NORTHEASTERN UNIVERSITY AND COLLABORATIONS INVOLVING NATIONAL LABORATORIES (NIST AND NREL), AND INDUSTRY (IBM, QUANTUM DESIGN, AND QNAMI). THE RESEARCH AND TRAINING ACTIVITIES ARE CENTERED AROUND THREE HIGHLY INTERLINKED THRUSTS. (1) INVESTIGATION OF HYBRID STRUCTURES OF QUBITS INTERACTING WITH ELECTROMAGNETIC FIELDS, SPINS, IONS, QUANTUM DOTS, AND OTHER SYSTEMS TO GAIN A DEEPER UNDERSTANDING AND ADVANCEMENT OF QUANTUM SENSING AND TRANSDUCTION TECHNOLOGIES. (2) RATIONAL DESIGN AND IN-DEPTH EVALUATION OF DEFECT QUBITS IN TWO-DIMENSIONAL HOST MATERIALS, INCLUDING EFFECTS OF SPIN-ORBIT COUPLINGS, PHONONS, NUCLEAR SPINS, AND TEMPERATURE. AND (3), LOW-TEMPERATURE NANOSCALE MAPPING AND EXPLORATION OF QUANTUM SYSTEMS USING A COMMERCIAL CRYOGENIC SCANNING DIAMOND-NITROGEN-VACANCY MAGNETOMETER (SNVM) - THE FIRST OF ITS KIND AT AN MSI IN THE US?WITH UNPRECEDENTED RESOLUTION AND SENSITIVITY FOR UNRAVELING THE FUNDAMENTALS OF EXOTIC CHARGE AND SPIN PHENOMENA AND ACHIEVING IMPROVED QUBIT DESIGNS. UNDERGRADUATE, GRADUATE, AND POSTDOCTORAL STUDENTS AND FACULTY AT HU ARE PARTICIPATING VIGOROUSLY IN EXPERIMENTAL AND THEORETICAL RESEARCH AND TRAINING ACTIVITIES, CUTTING ACROSS ALL THREE THRUSTS IN THE PROJECT. QISE WORKFORCE DEVELOPMENT EFFORTS INCLUDE: WORKSHOPS INVOLVING HU STUDENTS AND FACULTY TO IGNITE AWARENESS ABOUT VARIOUS QISE TRAINING PROGRAMS AT THE NATIONAL LABS AND R1 UNIVERSITIES; OPPORTUNITIES TO COLLABORATE WITH NATIONAL AND INDUSTRY PARTNERS, INCLUDING ACCESS TO IBM CLOUD FOR QUANTUM COMPUTING AND NORTHEASTERN UNIVERSITY?S INTEGRATED EQUAL PLATFORM FOR HANDS-ON TRAINING IN GROWING, FABRICATING, AND CHARACTERIZING QUBIT MATERIALS AND DEVICES; AND, DEVELOPMENT OF NEW QISE COURSES TO SUPPORT A PROFESSIONAL QISE MASTER?S DEGREE PROGRAM AT HU. OUTREACH ACTIVITIES INCLUDE THE CREATION OF A WEB PORTAL TO HIGHLIGHT RECENT QISE DISCOVERIES AND VIDEO RECORDINGS OF MONTHLY PROJECT SEMINARS AND E-SUMMER SCHOOLS TO EDUCATE AND ENGAGE THE PUBLIC IN QISE TOPICS. THIS PROJECT IS JOINTLY FUNDED BY THE OFFICE OF MULTIDISCIPLINARY ACTIVITIES (MPS/OMA) AND TECHNOLOGY FRONTIERS PROGRAM (TIP/TF). THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

CREST NANOSCALE ANALYTICAL SCIENCES RESEARCH AND EDUCATION CENTER

POSTDOCTORAL TRAINING IN GENERAL PEDIATRIC AND PUBLIC HEALTH DENTISTRY AND DENTAL HYGIENE

CENTERS OF EXCELLENCE

HOWARD UNIVERSITY GENERAL CLINICAL RESEARCH CENTER

COVID-19 STUDENT EMERGENCY SOLUTIONS PROJECT

GENERAL RESEARCH AND TECHNOLOGY ACTIVITY

EWP IN HOWARD COUNTY - 2019.

HISPANIC-SERVING INSTITUTIONS PROGRAM (STEM)

LSAMP- WASHINGTON BALTIMORE HAMPTON ROADS ALLIANCE (SENIOR-LEVEL ALLIANCE)

2015-2020 WASHINGTON BALTIMORE HAMPTON ROADS (WBHR) LOUIS STOKES ALLIANCES FOR MINORITY PARTICIPATION PROGRAM

AIDS EDUCATION TRAINING CENTERS

INTEGRATION OF AI LITERACY AND AI-ENHANCED PEDAGOGICAL APPROACHES AND TOOLS INTO POST-SECONDARY EDUCATION: A COLLABORATIVE INITIATIVE BETWEEN HOWARD UNIVERSITY AND BOWIE STATE UNIVERSITY

MECHANISMS OF APOE-INDUCED PRECLINICAL ALZHEIMER'S PATHOPHYSIOLOGY IN HUMAN OLFACTORY SYSTEM

EARLY HEAD START

HEALTH CENTER PROGRAM

RYAN WHITE PART C OUTPATIENT EIS PROGRAM

HOWARD UNIVERSITY HOSPITAL SCREENING, BRIEF INTERVENTION AND REFERRAL TO TREATMENT (SBIRT) COMMUNITY EXPANSION INITIATIVE

EXPERIMENTAL CENTRIC BASED ENGINEERING CURRICULUM FOR HBCUS

HEAD START AND EARLY HEAD START

2019 CHARLES B. RANGEL INTERNATIONAL AFFAIRS GRADUATE FELLOWSHIP. THIS IS THE INITIAL INSTALLMENT.

THE 2017 CHARLES B. RANGEL INTERNATIONAL AFFAIRS PROGRAM

RYAN WHITE TITLE IV WOMEN, INFANTS, CHILDREN, YOUTH AND AFFECTED FAMILY MEMBERS AIDS HEALTHCARE

RYAN WHITE TITLE IV WOMEN, INFANTS, CHILDREN, YOUTH AND AFFECTED FAMILY MEMBERS AIDS HEALTHCARE

LSAMP- WASHINGTON BALTIMORE HAMPTON ROADS ALLIANCE

THE 2016 CHARLES B. RANGEL INTERNATIONAL AFFAIRS PROGRAM

2018 CHARLES B. RANGEL INTERNATIONAL AFFAIRS PROGRAM

THE 2015 CHARLES B. RANGEL INTERNATIONAL AFFAIRS GRADUATE FELLOWSHIP AND SUMMER ENRICHMENT PROGRAMS

HOWARD UNIVERSITY ADVANCE-IT: WOMEN OF COLOR FACULTY IN STEM AS CHANGE AGENTS

ENDOWMENT

CHARLES B. RANGEL INTERNATIONAL AFFAIRS GRADUATE FELLOWSHIP AND CHARLES B. RANGEL INTERNATIONAL AFFAIRS SUMMER ENRICHMENT PROGRAM

COMPREHENSIVE HIGH-IMPACT HIV PREVENTION PROJECTS FOR COMMUNITY-BASED ORGANIZATIONS

INTERNATIONAL AFFAIRS PROGRAM

2020 THOMAS R. PICKERING FOREIGN AFFAIRS FELLOWSHIP GRADUATE PROGRAM. THIS IS THE FIRST FUNDING INSTALLMENT

2019 THOMAS R. PICKERING FOREIGN AFFAIRS FELLOWSHIP GRADUATE PROGRAM. THIS IS THE INITIAL INSTALLMENT.

SCHOLARSHIPS FOR DISADVANTAGED STUDENTS

ELUCIDATING OLFACTORY-BASED EPIGENETIC MEDIATION OF SOCIAL CONTEXTS ON STRESS RESPONSE ACROSS LIFE SPAN IN LOW SES INNER-CITY MINORITY POPULATIONS - ABSTRACT THERE IS SUBSTANTIAL ETHNIC AND RACIAL INEQUITY IN THE BURDEN OF SOCIAL ADVERSITIES ACROSS LIFE SPAN, AND DISPARITIES IN SEVERAL ADULT CHRONIC DISEASES CAN BE TRACED TO SOCIAL INEQUALITIES EXPERIENCED IN CHILDHOOD. SOCIAL ADVERSITIES SUCH AS POVERTY, HARSH PARENTING, NEIGHBORHOOD DISORGANIZATION, FAMILY INSTABILITY, AND PARENTAL INCARCERATION ARE PARTICULARLY PERVASIVE IN INNER-CITY, AFRICAN AMERICAN (AA) POPULATIONS; AND CAN HAVE SUBSTANTIAL IMPACT ON BIOLOGICAL PROCESSES THAT PUT THEM AT RISK FOR CHRONIC STRESS DISORDERS (E.G. POSTTRAUMATIC STRESS DISORDER, PTSD) AND METABOLIC DISEASES. PREVIOUSLY, WE OBSERVED THAT OLFACTORY BULB (OB) VOLUMES WERE SUBSTANTIALLY REDUCED IN AA ADULTS WHO DEVELOPED PTSD FOLLOWING SEVERE CHILDHOOD ADVERSITIES, COMPARED TO THOSE WITH SIMILAR EXPOSURES WHO DID NOT DEVELOP PTSD, WHICH IS CONGRUENT WITH ANIMAL STUDIES SHOWING THAT MATERNAL DEPRIVATION REDUCED OB SIZE. YET HOW THESE SOCIAL EXPOSURES BECOME TRANSLATED INTO CHRONIC HEALTH DISORDERS, IS UNCLEAR. EPIGENETIC FACTORS (I.E. MODIFICATIONS TO THE GENOME THAT ARE NOT CHANGES IN NUCLEOTIDE SEQUENCE) HAVE BEEN POSITED TO PLAY CRITICAL ROLES IN MEDIATING THE IMPACT OF ENVIRONMENTAL EXPOSURES ON HEALTH, DUE TO THEIR INFLUENCE ON DEVELOPMENTAL PLASTICITY AND LONG-TERM FUNCTIONAL BIOLOGY. OUR PROPOSED STUDY BUILDS UPON OUR R21 STUDY IN INNER-CITY AA POPULATIONS WHICH REVEALED THAT GROWTH ARREST SPECIFIC 5 (GAS5), A NON-CODING RNA (LNCRNA) LIKELY PLAYS AN EPIGENETIC ROLE AS A DECOY, DIVERTING GLUCOCORTICOIDS FROM BINDING TO GLUCOCORTICOID RESPONSE ELEMENTS (GRE) IN THE PROMOTER REGIONS OF GENES THAT RESPOND TO GLUCOCORTICOIDS AND PREVENTING DOWNSTREAM MOLECULAR AND PHYSIOLOGICAL EFFECTS. AFRICAN AMERICANS WITH ELEVATED GAS5 LEVELS, HAD LARGER OB VOLUMES, LOWER AFTERNOON CORTISOL LEVELS AND LOWER SYMPATHETIC AROUSAL INDEPENDENT OF BURDEN OF NEIGHBORHOOD DISORDER AND PERCEIVED SOCIAL STRESS AND RACIAL DISCRIMINATION. HOWEVER, OUR STUDIES ALSO REVEALED THAT SOCIAL CONNECTEDNESS AND DAILY SPIRITUAL EXPERIENCE SCALE ALSO MODERATED A BROAD SPECTRUM OF STRESS RESPONSIVE BEHAVIORS (E.G. PERCEIVED STRESS, AFFECT, SLEEP DISRUPTIONS, RISK TAKING, AND RESILIENCE), THEREBY PROVIDING A STRONG JUSTIFICATION TO INVESTIGATE GENOME-WIDE EPIGENOMIC MECHANISMS OF RESPONSE TO SOCIAL ADVERSITIES. AS A RESULT, WE PROPOSE A 5-YEAR PROSPECTIVE STUDY INVOLVING GENOME-WIDE NONCODING RNA PROFILING OF 300 AA WITH DIMENSIONAL DIFFERENCES IN CHILDHOOD SOCIAL ADVERSITIES. OUR SPECIFIC AIMS ARE: (1) CONDUCT BASELINE MICRORNA (MIRNA), LNCRNA AND MRNA PROFILING IN OLFACTORY NEURONS (ON) OF AA COHORTS TO EXAMINE ASSOCIATIONS BETWEEN NONCODING RNA (NCRNA) AND CHILDHOOD SOCIAL ADVERSITIES; (2) QUANTIFY BASELINE ASSOCIATIONS BETWEEN NCRNA LEVELS, PERCEIVED SOCIAL STRESS AND RACIAL DISCRIMINATION, SOCIAL CONNECTEDNESS, SPIRITUAL EXPERIENCE SCALE, AND BOTH BEHAVIORAL AND NEUROPHYSIOLOGIC MEASURES OF STRESS; AND (3) INVESTIGATE MEDIATIONAL ROLES OF NCRNA ON THE PREDICTIVE INFLUENCES OF CUMULATIVE EXPOSURES TO NEIGHBORHOOD STRESS, POVERTY, SOCIAL STRESS, PERCEIVED DISCRIMINATION AND OTHER SOCIAL DISADVANTAGES ON 12-MONTH TRAJECTORY IN STRESS RESPONSE BEHAVIORS. OUR OVERARCHING HYPOTHESIS IS THAT INTERACTIONS BETWEEN MIRNA AND LNCRNA WILL PARTIALLY MEDIATE EFFECTS OF THESE ADVERSE SOCIAL CONTEXTS (E.G. POVERTY, NEIGHBORHOOD DISORGANIZATION, FAMILY INSTABILITY, AND PARENTAL INCARCERATION) ON BIOLOGICAL PROCESSES RELATED TO STRESS RESPONSE ( E.G. GR SIGNALING, IMMUNE SIGNALING, CIRCADIAN MOLECULAR ALTERATIONS, AND ELEVATED SYMPATHETIC TONE) AND STRESS RESPONSIVE BEHAVIORS (PERCEIVED STRESS, PSYCHIATRIC, SLEEP DISRUPTIONS, RISK TAKING, AND RESILIENCE). THIS PROJECT IS INNOVATIVE IN USING NON-INVASIVELY DERIVED ON TO INVESTIGATE INTRANEURONAL EPIGENETIC MECHANISMS IN A PROSPECTIVE DESIGN, AND IN USE OF MICROSCOPY TO EXPLORE INTRANEURONAL IN

COVID RELIEF FOR BIOFUEL PRODUCERS GRANTS

STRENGTHENING INSTITUTIONS - HISPANIC SERVING INSTITUTIONS

AMERICAN RESCUE PLAN ACT FUNDING FOR HEALTH CENTERS

HOWARD COLLEGE MAKING DREAMS REAL (REACH, EMPOWER, APPLY, LAUNCH)

HOWARD CENTER CCBHC PLANNING, DEVELOPMENT, AND IMPLEMENTATION FOR CHITTENDEN COUNTY, VERMONT - HOWARD CENTER PROPOSES TO ENHANCE AND EXPAND ITS ARRAY OF PROGRAMS AND SERVICES TO MEET CERTIFIED COMMUNITY BEHAVIORAL HEALTH CLINIC CERTIFICATION CRITERIA. ADDING TO HOWARD CENTER’S ALREADY ROBUST PROGRAMMING WILL PROVIDE COMPREHENSIVE, COORDINATED BEHAVIORAL HEALTH CARE THAT IS PERSON- AND FAMILY-CENTERED AND WILL INCLUDE A RANGE OF OUTREACH, SCREENING, ASSESSMENT, TREATMENT, CARE COORDINATION, AND RECOVERY SUPPORTS IN ALIGNMENT WITH CCBHC CERTIFICATION CRITERIA. THIS PROJECT WILL SERVE THE PEOPLE OF CHITTENDEN COUNTY, VERMONT.

BIPARTISAN INFRASTRUCTURE LAW (BIL): GOLF COAST DECARB SYSTEM THE GULF COAST DECARB SYSTEM (GCDS) IS A FEED STUDY FOR A 600+ MILE, REGIONAL, COMMERCIAL-SCALE, COMMON CARRIER, CO2 PIPELINE SYSTEM FOR MOVING SUPERCRITICAL ANTHROPOGENIC CO2 FROM MULTIPLE CO2 SOURCES TO MULTIPLE CO2 SINKS ON THE GULF COAST FROM THE PORT OF CORPUS CHRISTI, TX TO DONALDSONVILLE, LA ADJACENT TO THE MISSISSIPPI RIVER.

HOWARD UNIVERSITY BELTSVILLE CENTER FOR CLIMATE SYSTEM OBSERVATION HOWARD UNIVERSITY IS LEADING A TRANSFORMATION OF THE ATMOSPHERIC SCIENCES; A DISCI

MOLECULAR ANALYSES OF RECQ1 FUNCTIONS IN GENOME MAINTENANCE

HOWARD UNIVERSITY IS LEADING A TRANSFORMATION OF THE ATMOSPHERIC SCIENCES; -- A DISCIPLINE WHERE MINORITIES WHO HAVE BEEN TRADITIONALLY UNDERREPRESEN

ADVANCING AGING RESEARCH THROUGH DEVELOPMENT OF MINORITY GERONTOLOGISTS

UPWARD BOUND IS A FEDERALLY FUNDED PRE-COLLEGE PROGRAM THAT PROVIDES HIGH SCHOOL STUDENTS WITH THE SKILLS AND MOTIVATION NECESSARY TO COMPLETE SECONDARY SCHOOL AND TO ENTER A POSTSECONDARY INSTITUTION

CENTRAL AUTONOMIC CONTROL, AGING AND OXIDATIVE STRESS

ACE IMPLEMENTATION GRANT: STEM GLOBAL UNDERGRADUATE RESEARCH INITIATIVE

IN VITRO AND IN VIVO STUDIES OF CYTOMEGALOVIRUS MIE GENE REGULATION

INSTITUTIONAL PORTION OF SECTION 18004(C) OF THE CORONAVIRUS AID, RELIEF, AND ECONOMIC SECURITY (CARES) ACT

MEDIATORS OF LITHIUM ACTION IN OLFACTORY EPITHELIUM

IMPROVE EXISTING AIRPORT

THE HOWARD UNIVERSITY SCORE PROGRAM

BROADENING PARTICIPATION IN ECONOMICS: THE AEA SUMMER PROGRAM WITH INCLUSIVE MENTORING

CENTERS OF EXCELLENCE

HEALTH CAREERS OPPORTUNITY PROGRAM

BAYESIAN IMAGING AND ADVANCED SIGNAL PROCESSING FOR LANDMINE AND IED DETECTION USING GPR

1/2 HOWARD - HOPKINS COMPREHENSIVE ALLIANCE IN CANCER RESEARCH, EDUCATION, AND EQUITY (H2CAREE) - PROJECT SUMMARY IN RESPONSE TO NIH PAR-23-308, THE HOWARD-JOHNS HOPKINS COMPREHENSIVE ALLIANCE IN CANCER RESEARCH, EDUCATION AND EQUITY (H2CAREE) INITIATIVE AIMS TO ADVANCE CANCER CARE AND HEALTH EQUITY THROUGH THE PARTNERSHIP BETWEEN HOWARD UNIVERSITY (HU) AND THE JOHNS HOPKINS UNIVERSITY (JHU) SIDNEY KIMMEL COMPREHENSIVE CANCER CENTER (SKCCC). SITUATED IN THE VIBRANT DC, MARYLAND, AND VIRGINIA (DMV) AREA, THE TWO INSTITUTIONS COLLECTIVELY HAVE A DIRECT IMPACT ON A POPULATION OF 4 MILLION HISTORICALLY UNDERSERVED AFRICAN AMERICANS IN THE AREA, WITH OVER 2 MILLION BLACK RESIDENTS IN THE METROPOLITAN OF WASHINGTON DC AND BALTIMORE. FOCUSED ON DMV REGION, THE INITIATIVE STRIVES TO ADDRESS HEALTHCARE DISPARITIES IN THIS DIVERSE AND SIGNIFICANT DEMOGRAPHIC. HOWARD UNIVERSITY AND JOHNS HOPKINS UNIVERSITY POSSESS DISTINCTIVE STRENGTHS THAT COMPLEMENT EACH OTHER IN ACHIEVING THE PROPOSED GOAL THROUGH INTEGRATED RESEARCH, RESEARCH EDUCATION, AND OUTREACH. THE PRIMARY OBJECTIVES ARE TO ESTABLISH AND SUSTAIN COLLABORATIVE CANCER RESEARCH PROGRAMS WITH AN EMPHASIS ON HEALTH EQUITY, TO BOOST CANCER RESEARCH EDUCATION PROGRAMS AT HU, AND TO ADVANCE CANCER CARE FOR TRADITIONALLY UNDERSERVED POPULATIONS THROUGH OUTREACH ACTIVITIES. THE H2CAREE INITIATIVE COMPRISES OF FOUR CORES (ADMINISTRATIVE, OUTREACH, RESEARCH EDUCATION, AND PLANNING & EVALUATION); TWO FULL RESEARCH PROJECTS; ONE PILOT RESEARCH PROJECT; AND ONE SHARED RESOURCE CORE (DATA SCIENCE). WITH THESE ASSETS AND ACTIVITIES, THE PARTNERSHIP WILL: 1) THROUGH RESEARCH PROJECTS, THE SHARED RESOURCE CORE, AND THE RESEARCH EDUCATION CORE, INCREASE CANCER RESEARCH AND RESEARCH EDUCATION CAPACITY AT HU; 2) THROUGH THE RESEARCH PROJECTS, IMPROVE RESEARCH PROGRAMS FOCUSING ON CANCER HEALTH DISPARITY AT SKCCC; 3) THROUGH THE RESEARCH PROJECT AND THE RESEARCH EDUCATION CORE, INCREASE THE NUMBER OF INVESTIGATORS AND STUDENTS CONDUCTING CANCER HEALTH DISPARITIES RESEARCH; 4) THROUGH THE RESEARCH EDUCATION CORE AND OUTREACH CORE, PROMOTE THE DIVERSITY OF THE CANCER RESEARCH WORKFORCE BY INCREASING THE NUMBER OF AFRICAN AMERICAN STUDENTS PURSUING CANCER RESEARCH; AND 5) THROUGH THE OUTREACH CORE, DEVELOP AND IMPLEMENT CANCER OUTREACH AND EDUCATION INITIATIVES THAT BENEFIT BOTH LOCALLY, I.E. THE DMV REGION, AND NATIONALLY. ADDITIONALLY, THE PLANNING AND EVALUATION CORE WILL CONTINUALLY ASSESS/EVALUATE OUTCOMES OF THE CORES, RESEARCH PROJECTS, AND SHARED RESOURCES. TOGETHER, THE COLLECTION OF THE EFFORTS IN H2CAREE WILL CONTRIBUTE TO ELIMINATION OF CANCER HEALTH DISPARITIES.

PARTNERSHIP FOR REDUCED DIMENSIONAL MATERIALS

UPWARD BOUND PROGRAM

EXPANDING MAT ACCESS TO RURAL COMMUNITIES WITH MOBILE LOW-BARRIER BUPRENORPHINE - THE PRIMARY PURPOSE OF THE PROJECT IS TO EXPAND ACCESS TO THE LOW BARRIER BUPRENORPHINE MODEL BY OFFERING MAT FOR ADULTS WITH OUD WHO HAVE OTHERWISE BEEN UNSUCCESSFUL IN MAT, AND TO SUPPORT TREATMENT RETENTION. OUR POPULATION OF FOCUS INCLUDES ADULTS WITH OPIOID USE DISORDER NOT CURRENTLY RECEIVING MAT, PARTICULARLY THOSE ENGAGING IN HIGH-RISK BEHAVIORS AND WITH CO-OCCURRING DISORDERS WHO HAVE STRUGGLED TO SUSTAIN PROGRESS IN PREVIOUS TREATMENT EPISODES. OUR EMPHASIS IS ON PEOPLE IN RURAL COMMUNITIES WITH SIGNIFICANT BARRIERS TO TREATMENT AND OUR CATCHMENT AREA INCLUDES FRANKLIN AND GRAND ISLE COUNTIES AND RURAL PORTIONS OF CHITTENDEN COUNTY IN NORTHWEST VERMONT. WE PROPOSE TO EMBED OUTREACH AND ENGAGEMENT IN MOBILE SYRINGE SERVICE PROGRAMMING (SSP) USING A VEHICLE SIMILAR TO A VAN OR BUS SPECIALLY OUTFITTED FOR THIS PURPOSE. ABOARD THE MOBILE UNIT, A TRAINED OUTREACH WORKER WILL CONDUCT SCREENING AND PROVIDE LINKAGE TO MOBILE-BASED BUPRENORPHINE INDUCTION PROVIDED BY AN X-WAIVER PRESCRIBER. THE MOBILE UNIT WILL SERVE AS A BRIDGE TO COMPREHENSIVE CARE AT ONE OF OUR SPOKE PROGRAMS OR OTHER COMMUNITY OBOT.

DEVELOPING HISPANIC-SERVING INSTITUTIONS PROGRAM

EXTRACTING SOCIAL MEANING FROM LINGUISTIC STRUCTURES IN AFRICAN LANGUAGES

TAS::89 0331::TAS RECOVERY RECOVERY ACT: COUNTY OF HOWARD, MD ENERGY EFFICIENCY AND CONSERVATION BLOCK GRANT

SCHOOL BASED MENTAL HEALTH PROGRAM

COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - CONSTRUCTION - HOWARD CENTER PROPOSES A CONSTRUCTION PROJECT WITH EQUIPMENT. WE PLAN TO CONSTRUCT A PURPOSE-BUILT, ENVIRONMENTALLY EFFICIENT, AND ACCESSIBLE LONG-TERM OR PERMANENT HOME OF NEARLY 8,000 SQUARE FEET FOR 16 AGING ADULTS WHOSE MENTAL HEALTH CONDITIONS MAKE IT IMPOSSIBLE FOR THEM TO LIVE INDEPENDENTLY AND SAFELY. THE BUILDING THAT CURRENTLY HOUSES THE LAKEVIEW HOUSE RESIDENTIAL PROGRAM DOES NOT MEET CLIENT NEEDS, IS EXPENSIVE TO MAINTAIN, AND CARRIES WITH IT THE MONTHLY COST OF LEASE PAYMENTS. AN APPROPRIATE AND EFFICIENT ENVIRONMENT WILL IMPROVE THE LIVES AND OUTCOMES FOR RESIDENTS, ADD VALUE TO VERMONT’S MENTAL HEALTH SYSTEM OF CARE FOR YEARS TO COME, AND ELIMINATE THE COST OF A LEASE FROM HOWARD CENTER’S OBLIGATIONS. THIS IS THE ONLY PROJECT PLANNED FOR THIS AWARD.

HALF THE SKY TECHNOLOGY AND MEDIA ENGAGEMENT INITITATIVE

CAPTURING MAGNETIC PATTERNS ON LEGACY TAPES

RYAN WHITE PART C OUTPATIENT EIS PROGRAM

2013 CHARLES B. RANGEL FELLOWSHIP

CHARLES B. RANGEL FOREIGN AFFAIRS FELLOWSHIP AND SUMMER ENRICHMENT PROGRAM

HOWARD UNIVERSITY'S RALPH J. BUNCHE INTERNATIONAL AFFAIRS CENTER FOR THE CONTINUED SUPPORT OF THE CHARLES B. RANGEL INTERNATIONAL AFFAIRS PROGRAM.

UPWARD BOUND

GENES, EXERCISE, NEUROCOGNITIVE AND NEURODEGENERATION: COMMUNITY-BASED APPROACH

INTERN MONEY

POSTDOCTORAL TRAINING IN GENERAL, PEDIATRIC AND PUBLIC HEALTH DENTISTRY AND DENTAL HYGIENE

SCHOLARSHIPS FOR DISADVANTAGED STUDENTS

RESEARCH TRAINING IN THE PREVENTION OF DRUG ABUSE & AIDS IN COMMUNITIES OF COLOR

2012-RANGEL FELLOWSHIP AND SUMMER ENRICHMENT PROGRAMS

EISENHOWER FOUNDATION MENTORING ENHANCEMENT PROGRAM

EMERGENCY FINANCIAL AID GRANTS TO STUDENTS UNDER SECTION 18004 OF THE CORONAVIRUS AID, RELIEF, AND ECONOMIC SECURITY (CARES) ACT

CHARLES B. RANGEL INTERNATIONAL AFFAIRS GRADUATE FELLOWSHIP AND SUMMER ENRICHMENT PROGRAM

MACHINE ASSISTED QUANTUM MAGNETISM

IMPROVE EXISTING AIRPORT

STRESS, SLEEP AND CARDIOVASCULAR RISK

SCHOLARSHIPS FOR DISADVANTAGED STUDENTS

THE UPWARD BOUND PROGRAM SERVES 98 DISADVANTAGED STUDENTS IN HERTFORD, BERTIE AND NORTHAMPTON COUNTIES IN NORTHEASTERN NORTH CAROLINA.

BUILDING CONNECTIONS AND LEARNING COMMUNITIES AMONG EDUCATORS AND RESEARCHERS AT HBCUS

ADDICTION MEDICINE FELLOWSHIP

SURVEILLANCE OF HIV POSITIVE PRE-ARTS PERSONS BY HU IN PARTNERSHIP W SANAC

HOWARD UNIVERSITY NWDP PROJECT

DOMESTIC WATER GRANTS - REGULAR

HEALTH CAREERS OPPORTUNITY PROGRAM

IMPROVE EXISTING AIRPORT CONSTRUCT AIRCRAFT RESCUE & FIRE FIGHTIN

TRANSITION TO TEACHING PROGRAM -- NATIONAL

PURPOSE: THE LEAD-BASED PAINT HAZARD REDUCTION (LHR) GRANT PROGRAM IS TO MAXIMIZE THE NUMBER OF CHILDREN UNDER THE AGE OF SIX PROTECTED FROM LEAD POISONING BY ASSISTING STATES, CITIES, COUNTIES/PARISHES, NATIVE AMERICAN TRIBES OR OTHER UNITS OF LOCAL GOVERNMENT IN UNDERTAKING COMPREHENSIVE PROGRAMS TO IDENTIFY AND CONTROL LEAD-BASED PAINT HAZARDS IN ELIGIBLE PRIVATELY-OWNED RENTAL OR OWNER-OCCUPIED HOUSING POPULATIONS. IN ADDITION, THERE IS HEALTHY HOMES SUPPLEMENTAL FUNDING AVAILABLE THAT IS INTENDED TO ENHANCE THE LEAD-BASED PAINT HAZARD CONTROL ACTIVITIES BY COMPREHENSIVELY IDENTIFYING AND ADDRESSING OTHER HOUSING HAZARDS THAT AFFECT OCCUPANT HEALTH. INFORMATION ABOUT WHERE THE SUPPLEMENTAL FUNDING CAN BE USED CAN BE FOUND AT. HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/HEALTHY_HOMES/PROJECT_DESCRIPTIONS; ACTIVITIES TO BE PERFORMED: PROGRAM FUNDS WILL BE AWARDED TO APPLICANTS TO ACCOMPLISH THE FOLLOWING OBJECTIVES: A. TARGETED UNITS: TARGET LEAD HAZARD CONTROL EFFORTS IN HOUSING UNITS WHERE CHILDREN LESS THAN 6 YEARS OF AGE ARE AT GREATEST RISK OF LEAD POISONING (PRE-1960, AND, ESPECIALLY, PRE-1940 CONSTRUCTION), WHICH HAS HISTORICALLY INCLUDED CHILDREN IN LOW-INCOME AND MINORITY NEIGHBORHOODS, TO REDUCE THE LIKELIHOOD OF ELEVATED BLOOD LEAD LEVELS IN THESE CHILDREN. B. COST EFFECTIVENESS: UTILIZE COST-EFFECTIVE LEAD HAZARD CONTROL METHODS AND APPROACHES THAT ENSURE THE LONG-TERM SAFETY OF THE BUILDING OCCUPANTS. C. CAPACITY: BUILD LOCAL CAPACITY OF TRAINED AND CERTIFIED INDIVIDUALS AND FIRMS TO ADDRESS LEAD HAZARDS SAFELY AND EFFECTIVELY DURING LEAD HAZARD CONTROL, RENOVATION, REMODELING, AND MAINTENANCE ACTIVITIES. ANOTHER CORE ELEMENT FOR CAPACITY INCLUDES THE DEVELOPMENT OF COMPREHENSIVE, COMMUNITY-BASED APPROACHES TO INTEGRATING THIS GRANT PROGRAM WITHIN OTHER LOCAL INITIATIVES THROUGH PUBLIC AND PRIVATE PARTNERSHIPS THAT ADDRESS HOUSING RELATED HEALTH AND SAFETY HAZARDS AND/OR SERVE LOW-INCOME FAMILIES WITH CHILDREN UNDER THE AGE OF SIX (6). D. AFFIRMATIVE MARKETING: ESTABLISH AND IMPLEMENT A DETAILED PROCESS OF MONITORING AND ENSURING THAT UNITS MADE LEAD-SAFE ARE AFFIRMATIVELY MARKETED, AND PRIORITY GIVEN, TO FAMILIES WITH CHILDREN UNDER AGE 6 YEARS FOR NOT LESS THAN THREE YEARS. E. DATA COLLECTION: GATHER PRE- AND POST-TREATMENT DATA THAT SUPPORTS AND VALIDATES LEAD HAZARD CONTROL INVESTMENTS. PROGRAM DATA COLLECTED SHOULD SUPPORT THE EVALUATION OF GRANT PROGRAM ACTIVITIES AND OUTCOMES. F. TARGETED OUTREACH AND EDUCATION: CONDUCTING TARGETED OUTREACH, AFFIRMATIVE MARKETING, EDUCATION OR OUTREACH PROGRAMS ON LEAD HAZARD CONTROL AND LEAD POISONING PREVENTION DESIGNED TO INCREASE THE ABILITY OF THE APPLICANT TO DELIVER THE SPECIFIED LEAD HAZARD CONTROL SERVICES THROUGH THIS PROGRAM; INCLUDING EDUCATING OWNERS OF ELIGIBLE RENTAL PROPERTIES, TENANTS, AND OTHERS ON THE BENEFITS AND EXPECTATIONS OF PARTICIPATING IN THIS PROGRAM PROVIDED BY "TITLE X" OF THE RESIDENTIAL LEAD-BASED PAINT HAZARD REDUCTION ACT OF 1992.; EXPECTED OUTCOMES: TO IDENTIFY AND CLEAN UP DANGEROUS LEAD IN LOW-INCOME FAMILIES’ HOMES WHERE LOW-INCOME FAMILIES WERE CHILDREN 6 AND UNDER RESIDE. THESE INVESTMENTS WILL PROTECT FAMILIES AND CHILDREN BY TARGETING SIGNIFICANT LEAD AND HEALTH HAZARDS IN OVER 3,700 LOW-INCOME HOMES FOR WHICH OTHER RESOURCES ARE NOT AVAILABLE.; INTENDED BENEFICIARIES: TO ASSIST STATES, CITIES, COUNTIES/PARISHES, NATIVE AMERICAN TRIBES OR OTHER UNITS OF LOCAL GOVERNMENT IN UNDERTAKING COMPREHENSIVE PROGRAMS TO IDENTIFY AND CONTROL LEAD-BASED PAINT HAZARDS IN ELIGIBLE PRIVATELY-OWNED RENTAL OR OWNER-OCCUPIED HOUSING POPULATIONS WERE CHILDREN UNDER 6 RESIDE.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

EFFECTS OF STANDARDIZED AEROBIC EXERCISE-TRAINING ON NEUROCOGNITIVE AND NEURODEGE

COMMUNITY DEVELOPMENT BLOCK GRANTS/ENTITLEMENT GRANTS

SCHOLARSHIPS FOR DISADVANTAGED STUDENTS

IN VIVO MRI MEASURES OF BRAIN METABOLISM IN TRAUMATIC BRAIN INJURY - PROJECT SUMMARY TRAUMATIC BRAIN INJURY (TBI) REPRESENTS A MAJOR PUBLIC HEALTH CONCERN IN THE UNITED STATES. TBI CAN RESULT IN LONG-TERM NEUROLOGICAL COMPLICATIONS, INCLUDING NEURODEGENERATION, BEHAVIORAL DYSFUNCTION, DEPRESSION AND EPILEPSY THAT SERIOUSLY AFFECT PATIENT QUALITY-OF-LIFE. BRAIN GLUCOSE UTILIZATION HAS BEEN FOUND DECREASED IN 60% OF PATIENTS WITH CHRONIC TBI AND IS ONE OF THE PROGNOSTIC INDICATORS FOR THE LONG-TERM OUTCOME OF TBI. BOTH ANIMAL AND HUMAN STUDIES HAVE IDENTIFIED THAT THE NEUROVASCULAR UNCOUPLING BETWEEN CEREBRAL BLOOD FLOW (CBF) AND BRAIN TISSUE ENERGY DEMANDS IS A KEY FACTOR FOR CEREBRAL METABOLIC CRISIS IN THE TBI BRAIN. THE NEUROVASCULAR UNCOUPLING RESULTS IN ENERGY MISMATCH THAT DISRUPTS NORMAL NEUROGLIAL FUNCTION AND ARRESTS REPAIRING PROCESS. DESPITE NUMEROUS CLINICAL TRIALS ON POTENTIAL THERAPIES, THERE IS NO U.S. FOOD AND DRUG ADMINISTRATION APPROVED DRUG THERAPY FOR THE TREATMENT OF TBI. ONE OF THE REASON CLINICAL TRIALS FAILED IS DUE TO THE INABILITY THAT CAN ACCURATELY EVALUATE THE REGION-SPECIFIC PERTURBATIONS OF BRAIN GLUCOSE METABOLISM AND DETERMINE IF A TREATMENT CAN RESTORE NEUROVASCULAR COUPLING IN THE TBI BRAIN. EXISTENT GLUCOSE MEASURING TECHNIQUES, INCLUDING MICRODIALYSIS, CONTINUING BLOOD GLUCOSE MONITORING, SPECTROSCOPY, OR POSITRON EMISSION TOMOGRAPHY (PET) WHICH USES TRACER RADIOISOTOPES, PROVIDE INSUFFICIENT RESOLUTION TO DETERMINE REGION-SPECIFIC GLUCOSE UTILIZATION IN THE BRAIN. IN THIS PROPOSAL, WE DETERMINE TO ASSESS THE UTILITY OF A NOVEL MRI-BASED CHEMICAL EXCHANGE SATURATION TRANSFER (CEST) IMAGING, TO PROVIDE THE NEEDED HIGH-RESOLUTION FOR MEASURING REGION-SPECIFIC METABOLISM FOR TBI. THE GLUCOSE DETECTING CEST MRI (GLUCOCEST) MEASURES BRAIN GLUCOSE BY DETECTING THE EXCHANGEABLE PROTON SIGNALS OF GLUCOSE WITHOUT USING RADIOISOTOPES AND GENERATES GLUCOSE MAPPING IN A RESOLUTION >100 TIMES HIGHER THAN PET SCANS. OUR PRELIMINARY AND PUBLISHED DATA HAVE DEMONSTRATED THAT GLUCOCEST MAY BE FEASIBLE TO DETECT THE DELAYED HYPOMETABOLISM OF DIFFUSE TBI IN RATS. WE PROPOSE TO COMBINE HIGH-RESOLUTION GLUCOCEST AND THE DYNAMIC CONTRAST ENHANCED (DCE) PERFUSION MRI FOR CONCOMITANT CBF MEASUREMENTS TO IDENTIFY THE NEUROVASCULAR COUPLING STATE FOLLOWING TBI OVER TIME. OUR AIMS ARE DESIGNED TO (1) IDENTIFY THE CONTRAST MECHANISM OF IN VIVO GLUCOCEST IN THE TBI BRAIN TO ENHANCE THE SENSITIVITY AND SPECIFICITY OF GLUCOCEST WITH ADVANCED ACQUISITION SCHEME AND ANALYTICAL MODELS, (2) CHARACTERIZE PERTURBATIONS IN BRAIN GLUCOSE METABOLISM AND PERFUSION DEFICITS IN THE TBI BRAIN, AND (3) DEMONSTRATE THE POTENTIAL APPLICATION OF THE DUAL-MODALITY CEST-DCE MRI TO NONINVASIVELY MONITOR THE TREATMENT EFFECTS OF A CLINICALLY-RECOMMENDED INTERVENTION FOR TBI. OVERALL, THESE STUDIES WILL PROVIDE A STRONG TECHNICAL AND SCIENTIFIC FOUNDATION TO MOVE THE FIELD FORWARD IN UTILIZATION OF ADVANCED MRI FOR PERSONALIZED CARE IN THE CLINICAL ARENA AND DETERMINE THE BEST TREATMENT STRATEGY FOR THE BRAIN INJURED PATIENTS.

SCHOLARSHIPS FOR DISADVANTAGED STUDENTS

UPWARD BOUND

PULMONARY HYPERTENSION AND THE HYPOXIC RESPONSE IN SCD

HOWARD UNIVERSITY SBIRT MEDICAL RESIDENCY PROGRAM

TARGETED HIV PREVENTION PROJECT FOR YOUNG TRANSGENDER PERSONS OF COLOR AND THEIR PARTNERS (THPP)

EXCESSIVE ALCOHOL DRINKING ASSOCIATED WITH GABA ALPHA 2-REGULATED TLR4 EXPRESSION

WASHINGTON AREA BASIC AND TRANSLATIONAL RESEARCH PROGRAM

IMPROVE EXISTING AIRPORT

DOMESTIC WATER GRANTS - REGULAR

VIOLENCE EXPOSURE, IMMUNE FUNCTION & HIV/AIDS RISKS IN AFRICAN AMERICAN YOUNG AD

AWARD PURPOSE: METHOW SALMON RECOVERY FOUNDATION (MSRF) IS A NON-PROFIT ORGANIZATION AND HAS ACTED AS A PROJECT SPONSOR FOR THE BUREAU OF RECLAMATION (RECLAMATION) IN THE METHOW SUB-BASIN SINCE 2004. DURING THAT PERIOD, MSRF HAS HELPED RECLAMATION CREATE A UNIQUE WORKING COMMUNITY IN THE TWISP COMMUNITY. THE MSRF OFFICE FUNCTIONS AS A COLLABORATIVE CENTER WHERE PROJECT IMPLEMENTERS AND COMMUNITY MEMBERS MEET FREQUENTLY TO IDENTIFY RESTORATION OPPORTUNITIES AND ADDRESS LANDOWNER NEEDS AND CONCERNS RELATED TO HABITAT RESTORATION ACTIONS. THE TWISP OFFICE ALSO PROVIDES OFFICE AND MEETING SPACE FOR THE METHOW WATERSHED ACTION TEAM, METHOW WATERSHED COUNCIL, METHOW BEAVER PROJECT, SEVERAL IRRIGATION COMPANIES, AND FOR THE RECLAMATION AREA LIAISON. ACTIVITIES TO BE PERFORMED INCLUDE: 1.COORDINATE BASIN-WIDE IDENTIFIED PROJECTS2.MANAGE SUGAR REACH PROJECTS3.MANAGE LOWER METHOW REACH PROJECT4.POST-PROJECT PERFORMANCE MONITORING5.WATER EFFICIENCY IRRIGATOR ASSISTANCEEXPECTED DELIVERABLES OR OUTCOMES: THIS PROJECT WILL ALLOW MSRF TO CONTINUE ASSISTING RECLAMATION IN DEVELOPING AND IMPLEMENTING PRIORITIZED PROJECT ACTIONS IN THE METHOW VALLEY, IN PART, TO MEET ITS OBLIGATIONS UNDER THE FEDERAL COLUMBIA RIVER POWER SYSTEM BIOLOGICAL OPINION.INTENDED BENEFICIARIES: MSRF EFFORTS WILL CARRY OUT THE PUBLIC PURPOSE OF MANAGING, DEVELOPING, AND MONITORING IDENTIFIED SALMON AND STEELHEAD HABITAT IMPROVEMENT PROJECTS IN THE METHOW SUB-BASIN. BENEFITS INCLUDE IMPROVED INSTREAM HABITAT COMPLEXITY, REMOVE BARRIERS, INCREASE INSTREAM FLOWS, AND UPGRADE DEFICIENT IRRIGATION SCREENS. SUBRECIPIENT ACTIVITIES (IF KNOWN OR SPECIFIED AT TIME OF AWARD): N A

HOWARD/HOPKINS/PRINCE GEORGE'S COMMUNITY COLLEGE - PARTNERSHIP FOR RESEARCH AND EDUCATION IN MATERIALS

UPWARD BOUND PROGRAM

TAS::89 0321::TAS MOISTURE METRICS

ENDOWMENT

STUDENT SUPPORT SERVICES PROGRAM

HOME INVESTMENT PARTNERSHIPS PROGRAM

SCHOLARSHIPS FOR DISADVANTAGED STUDENTS

SCHOLARSHIPS FOR DISADVANTAGED STUDENTS

STUDENT SUPPORT SERVICES PROGRAM

EFFICACY OF NOVEL TRIPLE UPTAKE INHIBITORS IN TREATING ALCOHOLISM AND DEPRESSION

STUDENT SUPPORT SERVICES PROGRAM

NOCTURNAL BLOOD PRESSURE AND POSTTRAUMATIC STRESS DISORDER IN AFRICAN AMERICANS

PURPOSE IS WATERSHED PROTECTION AND AGRICULTURAL WATER MGMTNCLUDE BRINGING THE BLUE CREEK DAM INTO COMPLIANCE WITH UT DAM SAFETY AND NRCS MINIMUM STANDARDS FOR HIGH HAZARD DAMS.