Ohio University

CARES ACT HEERF INSTITUTIONAL PORTION FUNDING FOR OHIO UNIVERSITY

CARES ACT HEERF STUDENT PORTION FUNDING FOR OHIO UNIVERSITY

PORTSMOUTH PUBLIC OUTREACH SUPPORT

NEW VIVARIUM TO EXPAND BIOMEDICAL RESEARCH CAPACITY AT OHIO UNIVERSITY - PROJECT SUMMARY/ABSTRACT OHIO UNIVERSITY (OHIO) IS AN INSTITUTION OF EMERGING EXCELLENCE COMMITTED TO CONDUCTING FOCUSED BIOMEDICAL RESEARCH. THROUGH ESTABLISHMENT AND STRENGTHENING OF TWO RESEARCH INSTITUTES (THE DIABETES INSTITUTE/DI AND THE OHIO MUSCULOSKELETAL AND NEUROLOGICAL INSTITUTE/OMNI) OVER THE PAST TWO DECADES, OHIO HAS DEMONSTRATED A LONGSTANDING COMMITMENT TO INTEGRATING CLINICAL EDUCATION, PATIENT CARE, AND RESEARCH TO HELP RESIDENTS AND TRAINEES DIRECTLY CONFRONT THE LOCAL AND GLOBAL CHALLENGES OF OBESITY, DIABETES, PAIN, AND AGING IN PLACE. RECENT STRATEGIC INVESTMENTS HAVE STRENGTHENED THE RESEARCH ENVIRONMENT WITHIN THESE INSTITUTES AND, CONSEQUENTLY, BOLSTERED THE OVERALL BIOMEDICAL RESEARCH PORTFOLIO OF THE ENTIRE UNIVERSITY. IN FACT, THESE TWO INSTITUTES ARE RESPONSIBLE FOR OVER HALF OF THE UNIVERSITY’S NIH FUNDING PORTFOLIO AND INCLUDE A CADRE OF SUCCESSFUL, MULTIDISCIPLINARY SCIENTISTS CONDUCTING BASIC, CLINICAL, AND POPULATION HEALTH RESEARCH. AS A RESULT OF RECENT EXPANSIONS AND FUNDING SUCCESSES IN THE DI AND OMNI, THERE IS NOW AN URGENT NEED TO IMPROVE THE OUTDATED BIOMEDICAL RESEARCH FACILITIES AND INFRASTRUCTURE AT OHIO. TO THAT END, THE INSTITUTION HAS SECURED $67 MILLION DOLLARS (MOST OF THE FUNDING REQUIRED) FOR A NEW BIOMEDICAL RESEARCH FACILITY, NAMED THE HERITAGE TRANSLATIONAL RESEARCH CENTER (HTRC). THE HTRC WILL FOSTER COLLABORATIVE RESEARCH AMONG INSTITUTE MEMBERS BY CONSOLIDATING RESEARCH CURRENTLY FRAGMENTED ACROSS NUMEROUS BUILDINGS ON CAMPUS AND PROMOTE COLLABORATION BETWEEN BASIC AND CLINICAL SCIENTISTS TO BOLSTER TRANSLATIONAL RESEARCH. THIS NEW FACILITY WILL ALSO MOVE RESEARCH EFFORTS TO SPACES THAT ARE PURPOSE-BUILT FOR RESEARCH AND VACATE AGING BUILDINGS THAT ARE NO LONGER APPROPRIATE FOR CONDUCTING MODERN BIOMEDICAL SCIENCES. THIS C06 PROJECT SEEKS TO SPECIFICALLY FUND THE CONSTRUCTION OF A VIVARIUM WITHIN THE TOP FLOOR OF THE HTRC TO SUPPORT THE ACTIVITIES OF THE ANIMAL-BASED RESEARCHERS OF DI AND OMNI. THE NEW VIVARIUM WILL PROVIDE OHIO WITH A CONTEMPORARY ANIMAL HOUSING FACILITY AND REPLACE AN EXISTING VIVARIUM IN AN AGED FACILITY, EXPANDING CAPACITY (INCREASING TOTAL MOUSE CAGES BY 64%), EFFICIENCY, AND BIOSECURITY AS WELL AS AUGMENT PROCEDURAL AND SHARED EQUIPMENT SPACE TO SUPPORT RODENT RESEARCH. A MAJOR IMPACT OF THE HTRC ANIMAL FACILITY WILL BE TO SUPPORT CURRENT AND FUTURE NIH-FUNDED PROJECTS BY OHIO RESEARCHERS, FACILITATE EXTERNAL COLLABORATIONS THAT RELY ON THE NOVEL MICE OR MOUSE TISSUES GENERATED BY DI OR OMNI INVESTIGATORS, AND ATTRACT FUTURE, PLANNED FACULTY HIRES WITHIN THESE INSTITUTES. ALIGNED WITH ITS EDUCATIONAL MISSION, OHIO WILL ALSO USE THIS BUILDING TO TRAIN GRADUATE, UNDERGRADUATE AND MEDICAL STUDENTS IN ANIMAL MODELS OF DISEASE. COMPLETION OF THE NEW TRANSLATIONAL RESEARCH FACILITY AT OHIO, WHICH RELIES ON BUILDING THE PROPOSED ANIMAL FACILITY, IS EXPECTED TO HAVE A POWERFUL AND SUSTAINED IMPACT ON THE TRANSLATIONAL RESEARCH EFFORTS OF DI AND OMNI; THEIR NIH-FUNDED RESEARCH; THE RESEARCH OF THEIR MANY EXTERNAL COLLABORATORS; REGIONAL COMPANIES THAT RELY ON OHIO’S INFRASTRUCTURE; OSTEOPATHIC MEDICAL SCHOOL RESEARCH LOCALLY AND NATIONALLY; AND THE UNDERSERVED SURROUNDING COMMUNITY.

STUDIES OF NUCLEAR ASTROPHYSICS, STRUCTURE, AND REACTIONS WITH NEUTRONS, RADIOACTIVE BEAMS, AND OTHER PROBES

NUCLEAR DYNAMICS AND ASTROPHYSICS IN FEW AND MANY-BODY SYSTEMS

MODULATING GROWTH HORMONE ACTION AS A TARGET FOR IMPROVED HEALTH AND LONGEVITY

PORTSMOUTH PUBLIC OUTREACH SUPPORT GRANT

MOTONEURONAL MECHANISMS UNDERLYING AGE-RELATED MUSCLE WEAKNESS - ABSTRACT FORTY-TWO PERCENT OF OLDER ADULTS HAVE ONE OR MORE PHYSICAL LIMITATIONS PERFORMING DAILY TASKS THAT ARE ESSENTIAL FOR MAINTAINING INDEPENDENCE IN THE COMMUNITY. AGE-RELATED WEAKNESS IS AN IMPORTANT CONTRIBUTOR TO PHYSICAL IMPAIRMENTS, AS WEAKNESS PREDISPOSES OLDER ADULTS TO A 4-FOLD INCREASE IN PHYSICAL LIMITATIONS. FOR DECADES, AGE-RELATED WEAKNESS WAS LARGELY ATTRIBUTED TO THE LOSS OF MUSCLE MASS, BUT RECENT DATA INDICATES THAT MASS PLAYS A LESSER ROLE THAN ORIGINALLY THOUGHT, HIGHLIGHTING THAT OTHER NEUROLOGICAL AND/OR MUSCLE QUALITY RELATED FACTORS ARE CRITICAL IN THE DEVELOPMENT OF WEAKNESS. DESPITE THE SIGNIFICANCE OF MAINTAINING PHYSICAL STRENGTH IN AGING, THE MAJORITY OF THE RESEARCH HAS FOCUSED ON MAINTAINING MUSCLE MASS. CONSIDERABLY LESS IS KNOWN REGARDING THE NEURAL MECHANISMS POTENTIALLY CONTRIBUTING TO AGE-RELATED WEAKNESS. THIS KNOWLEDGE GAP REPRESENTS A BARRIER TO THE DEVELOPMENT OF NEW INTERVENTIONS TO ENHANCE STRENGTH AND FUNCTION IN OLDER ADULTS. IN THIS APPLICATION WE WILL TEST THE CENTRAL HYPOTHESIS THAT AGE-RELATED WEAKNESS IS DUE, IN PART, TO UPREGULATION IN MOTOR NEURON (MN) SK CHANNELS (SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS) THAT RESULTS IN TYPE- DEPENDENT REDUCTIONS IN INTRINSIC MN EXCITABILITY AND FIRING RATES. PRIOR WORK INDICATES THAT AGING RESULTS IN REDUCED NUMBER OF MUS (THE A-MN AND THE MUSCLE FIBERS THAT IT INNERVATES) AND LOWER FIRING RATES. HOWEVER, PRIOR WORK HAS STOPPED SHORT OF DETERMINING WHETHER AGE-RELATED REDUCTIONS IN MU NUMBERS ARE RELATED TO CLINICALLY- MEANINGFUL WEAKNESS, AND DETERMINING THE IONIC MECHANISMS UNDERLYING REDUCED MN FIRING RATES IN AGING. IN THIS APPLICATION WE PROPOSE A SERIES OF PARALLEL, CROSS-SECTIONAL AND LONGITUDINAL ANIMAL (AIMS 1 AND 2) AND HUMAN EXPERIMENTS (AIM 3) TO TEST OUR CENTRAL HYPOTHESIS. AIM 1 WILL DETERMINE IF MN EXCITABILITY DYSFUNCTION IS INVOLVED IN AGE-RELATED WEAKNESS AND DETERMINE ITS TEMPORAL RELATIONSHIP TO MU LOSS IN MICE. AIM 2 WILL IDENTIFY THE CELLULAR MECHANISMS UNDERLYING MN EXCITABILITY DYSFUNCTION IN AGED MICE. AIM 3 WILL DETERMINE THE ROLE OF MN EXCITABILITY AND NUMBER IN CLINICALLY-MEANINGFUL, AGE-RELATED WEAKNESS IN OLDER ADULTS. THIS WORK ALIGNS WITH STATED GOALS FROM THE NATIONAL INSTITUTE ON AGING (NIA). THE KNOWLEDGE TO BE GAINED FROM THIS WORK HAS THE POTENTIAL TO FUNDAMENTALLY SHIFT THE FIELDS OF SARCOPENIA AND FRAILTY RESEARCH TOWARDS MN EXCITABILITY AS AN EARLY BIOMARKER FOR THE DEVELOPMENT OF WEAKNESS, AND IDENTIFYING KEY MN ION CHANNELS THAT COULD SERVE AS A NEUROTHERAPEUTIC TARGETS FOR TREATING OR PREVENTING AGE-RELATED WEAKNESS.

SAFE SCALABLE AND SEAMLESS SURFNAV4UAS SURFNAV4UAS

FRAMEWORKS: BAYESIAN ANALYSIS OF NUCLEAR DYNAMICS

CEACAM AND INSULIN ACTION

EXAMINING OUTCOMES OF A MULTI-COMPONENT, INDIVIDUALLY-TAILORED CONSULTATION PROCESS FOCUSED ON CLASSROOM MANAGEMENT FOR TEACHERS (K-5)

NOVEL PATHWAYS IN THE PATHOGENESIS AND PATHOPHYSIOLOGY OF NAFLD IN HISPANICS

BLOOD DONOR COMPETENCE, AUTONOMY AND RELATEDNESS ENHANCEMENT (BLOOD DONOR CARE)

OPIOID-IMPACTED FAMILY SUPPORT PROGRAM

EDUCATION RESEARCH PROGRAM

SPIN-POLARIZED SCANNING TUNNELING MICROSCOPY STUDIES OF NANOSCALE MAGNETIC AND SPINTRONIC NITRIDE

NEW GK-12: THE BOAT-OF KNOWLEDGE IN THE SCIENCE CLASSROOM (BOOKS IN CLASSROOM)

MECHANISMS OF SIGNALING IN OTOCONIAL ORGANS

1.0 GOALS AND OBJECTIVES OF THE PROJECT: THE PORTSMOUTH/PADUCAH PROJECT OFFICE (PPPO) REQUIRES THE SERVICES OF A WELL-QUALIFIED GRANTEE LOCATED

THEORETICAL AND COMPUTATIONAL STUDIES IN INTERMEDIATE ENERGY NUCLEAR PHYSICS

PIRE THE SPIN TRIANGLE - ATHENS, OHIO; HAMBURG, GERMANY; AND BUENOS AIRES, ARGENTINA: ADVANCING NANOSPINTRONICS AND NANOMAGNETISM

COGNITIVE PROCESSING AND SENTENCE COMPREHENSION IN SLI

NEURAL MECHANISMS OF AGE-RELATED WEAKNESS - ABSTRACT MORE THAN 40% OF OLDER ADULTS (OAS) REPORT LIMITATIONS TO PERFORMING TASKS THAT ARE ESSENTIAL TO MAINTAIN INDEPENDENCE. WEAKNESS IS AN IMPORTANT CONTRIBUTOR TO PHYSICAL IMPAIRMENTS; INDEED, WEAKNESS PREDISPOSES OAS TO A FOUR-FOLD INCREASE IN PHYSICAL LIMITATIONS. BECAUSE STRENGTH IS A VITAL FACTOR FOR HEALTH AND LONGEVITY, MORE COMPREHENSIVE UNDERSTANDING OF THE CAUSES OF WEAKNESS IS NEEDED TO DEVELOP TARGETED INTERVENTIONS TO ENHANCE STRENGTH AND FUNCTION IN OAS. WHILE AGE-RELATED LOSS OF MUSCLE MASS AND QUALITY ARE PARTLY RESPONSIBLE FOR WEAKNESS, THERE IS INCREASING EVIDENCE THAT DEFICITS IN NEURAL ACTIVATION ARE CRITICALLY LINKED TO AGE-RELATED WEAKNESS. IN PARTICULAR, WE AND OTHERS HAVE DEMONSTRATED THAT WEAKNESS ASSOCIATED WITH AGING AND OTHER CONDITIONS (E.G., DISUSE, INJURY, SEPSIS) IS DUE, IN PART, TO NEURAL HYPOEXCITABILITY. IN THIS APPLICATION, WE SEEK TO FUNDAMENTALLY ADVANCE OUR UNDERSTANDING OF THE MECHANISMS OF AND TREATMENT STRATEGIES FOR AGE-RELATED WEAKNESS AND MOBILITY LIMITATIONS THROUGH TRANSLATIONAL HUMAN (AIM 1) AND PRE-CLINICAL RODENT (AIM 2) EXPERIMENTS THAT, COLLECTIVELY, WILL PROVIDE STRONG DATA INDICATING A CAUSAL ASSOCIATION BETWEEN NEURAL HYPOEXCITABILITY AND AGE-RELATED WEAKNESS. THE FIRST AIM WILL TEST THE HYPOTHESIS THAT INDICES OF NEURAL HYPOEXCITABILITY ARE ASSOCIATED WITH GREATER FUTURE (LONGITUDINAL) LOSSES OF STRENGTH IN OAS. HERE, WE WILL LEVERAGE DATA FROM A PRIOR R01 TO CONDUCT A LONGITUDINAL STUDY IN HUMANS WHERE WE QUANTIFY INDICES OF NEURAL EXCITABILITY, LEAN MASS, STRENGTH, AND MOBILITY AFTER ~ 8-YEARS IN OLDER ADULTS. THESE DATA WILL BE USED TO DETERMINE THE RELATIVE CONTRIBUTION OF INDICES OF NEURAL EXCITABILITY AND THIGH LEAN MASS ON FUTURE DECLINE IN MUSCLE STRENGTH IN OLDER ADULTS, WITH A ROBUST DESIGN ACCOUNTING FOR ALTERNATIVE MECHANISMS. BY USING A LONGITUDINAL DESIGN IN HUMANS, THIS AIM WILL PROVIDE THE STRONGEST LEVEL OF EVIDENCE FOR NEURAL EXCITABILITY BEING A KEY PREDICTOR OF AGE-RELATED STRENGTH LOSS, WHICH IS A PARADIGM SHIFT AWAY FROM THE CURRENT CONSIDERATION OF PRIMARILY MUSCULAR FACTORS (E.G., MUSCLE MASS). THE SECOND AIM WILL CONSIST OF FOUR EXPERIMENTS. EXPERIMENTS 1-3 WILL USE A 5-HT2C AGONIST (LORCASERIN) WITH A WELL-KNOWN MECHANISM OF ACTION THAT INCREASES PERSISTENT INWARD CURRENTS AND MOTONEURON EXCITABILITY. SA2.1 WILL TEST THE HYPOTHESIS THAT THERE IS AN INVERTED U-SHAPE RELATIONSHIP BETWEEN 5-HT2C AGONIST DOSE AND MOTOR FUNCTION RESPONSE IN OLD MICE. SA2.2 WILL TEST THE HYPOTHESIS THAT A 5-HT2C AGONIST WILL ENHANCE MOTOR FUNCTION IN AGED MICE BY INCREASING NEURAL EXCITATION TO DEMONSTRATE THAT THE REDUCTION IN MN EXCITABILITY IS A SIGNIFICANT CONTRIBUTOR TO MOTOR DYSFUNCTION IN OLD MICE. SA2.3 WILL TEST CHRONIC EFFECTS OF LORCASERIN TREATMENT ON MOTOR UNIT NUMBER AND FUNCTION IN AGED MICE. SA2.4 WILL TEST THE IMPACT OF TAMOXIFEN-INDUCIBLE GENETIC DELETION OF 5-HT2C RECEPTORS IN MNS USING CRE-LOX SYSTEM. IN THE LONG-TERM, THIS PROOF-OF-CONCEPT, PROOF-OF-MECHANISM WORK COULD SERVE AS EVIDENCE FOR A NEUROTHERAPEUTIC AGENT TO ENHANCE MOTOR FUNCTION IN OLDER ADULTS.

STUDY OF STRUCTURE OF NUCLEI WITH NEUTRONS AND NUCLEAR DATA MEASUREMENTS FOR MFE

PURPOSE: STRENGTHEN APRON; REHABILITATE RUNWAY. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT REHABILITATES 5,600 FEET OF RUNWAY 7/25 PAVEMENT MARKINGS TO ENHANCE SAFE AIRFIELD OPERATIONS. THIS PROJECT STRENGTHENS 19,300 SQUARE YARDS OF THE MAIN APRON TO ACCOMMODATE A HEAVIER CLASS OF AIRCRAFT AND TO MEET RUNWAY SAFETY AREA AND RUNWAY PROTECTION ZONE STANDARDS. THIS GRANT FUNDS THE FINAL PHASE, WHICH INCLUDES CONSTRUCTION. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH ATHENS, OHIO.

CONGRESSIONALLY DIRECTED SPENDING FOR CONSTRUCTION PROJECTS - GROUNDBREAKING RESEARCH OVER THE LAST 20-YEARS IN THE KOPCHICK LABORATORY AT OHIO UNIVERSITY, SITUATED IN APPALACHIAN OHIO, HAS IDENTIFIED READILY TRANSLATABLE METHODS OF REVERSING THERAPY-RESISTANCE IN TUMORS, WHICH IS A MAJOR CAUSE OF CANCER MORTALITY. MAJOR EQUIPMENT FOR IMAGING AND NEXT-GENERATION SEQUENCING AT SINGLE CELL RESOLUTION ARE ESSENTIAL TO PROCESS TISSUE SAMPLES (HUMAN AND MOUSE) TO DETERMINE TUMOR THERAPY RESPONSE AND TUMOR GENE EXPRESSION WHICH ARE CRITICAL FOR PRECISELY PREDICTING AND DETERMINING THE OPTIMUM THERAPEUTIC APPROACH FOR EACH PATIENT. TO ASCERTAIN EFFICACY OF THE NOVEL ANTI-CANCER APPROACHES DISCOVERED AT OHIO UNIVERSITY AND FOR THE GENERATION OF PRE-CLINICAL AND CLINICAL DATA WHICH ARE ESSENTIAL FOR TRANSLATION OF THESE DISCOVERIES FROM THE BENCH TO THE BEDSIDE, SPECIFIC STATE-OF-THE-ART EQUIPMENT (DESCRIBED HERE AND NOT CURRENTLY AVAILABLE IN THE INSTITUTION) ARE REQUIRED. OVER THE LAST FOUR DECADES, OUR LABORATORY HAS PERFORMED EXTENSIVE AND AWARD-WINNING RESEARCH IN THE FIELDS OF ENDOCRINOLOGY, AGING, AND CANCER. USING GENETICALLY ENGINEERED IMMUNOCOMPETENT AND IMMUNOCOMPROMISED MOUSE MODELS, WE ARE STUDYING HUMAN CANCERS TO ASSESS THE THERAPEUTIC RESPONSE OF NOVEL TREATMENT APPROACHES THAT ENHANCE THE EFFICACIES OF FDA-APPROVED ANTI-CANCER CHEMOTHERAPY, TARGETED THERAPY, AND IMMUNOTHERAPY. ADDITIONALLY, BY PARTNERING WITH CLINICIANS ACROSS SOUTH-EASTERN OHIO AREA, WE HAVE ACCESS TO SEVERAL REPOSITORIES OF FRESH AND FROZEN TUMOR TISSUE SAMPLES FROM HUMAN PATIENTS THAT NEED ASSESSMENT OF GENE EXPRESSION, DNA MUTATIONS AND VARIATIONS WHICH ALLOWS DETERMINATION OF IDEAL THERAPEUTIC APPROACH FOR HIGHEST CHANCES OF RECOVERY. THEREFORE, THE ACQUISITION OF THE DESCRIBED EQUIPMENT FOR IMAGING AND NEXT-GENERATION SINGLE-CELL SEQUENCING WILL ALLOW THE QUALIFIED TEAM OF SCIENTISTS AND EXPERTS UNDER THE LEADERSHIP OF DR. KOPCHICK TO ELEVATE AND TRANSFORM THE LANDSCAPE OF CANCER PROGNOSES ACROSS APPALACHIA, WHICH INCLUDES 26 MILLION CONSTITUENTS ACROSS 423 COUNTIES AND ALSO PRESENTS A CANCER INCIDENCE AND MORTALITY RATE MARKEDLY HIGHER THAN THE NATIONAL AVERAGE. IN THE EXPANDED TECHNICAL CAPACITY OF RESEARCH ENABLED BY THE EARMARK FUNDS, OUR ADVANCES IN ANTI-CANCER THERAPY HAVE THE POTENTIAL TO BENEFIT MILLIONS OF CANCER PATIENTS WORLDWIDE.

RURAL APPALACHIAN LEADERS AND LOCAL YOUTH FOR STEM

IMPROVE EXISTING AIRPORT

TECHNICAL ASSISTANCE

THE RELIEF STUDY

POST-TRANSLATIONAL REGULATION OF ALPHA PSM PRODUCTION IN STAPHYLOCOCCUS AUREUS BY THE SMALL RNA TEG41

LINKING FAT METABOLISM TO HEPATIC FIBROSIS

DISTRIBUTED POWER FROM WASTEWATER DESIGN PLAN

THIS COMPETITIVE COOPERATIVE AGREEMENT FOR A RESEARCH AND DEVELOPMENT PROJECT ENTITLED, “NOVEL ULTRA-CONDUCTIVE CARBON ALUMINUM COMPOSITE CABLE FOR EFFICIENT POWER TRANSMISSION” IS AWARDED TO OHIO UNIVERSITY UNDER ARPA-E FOA NUMBER DE-FOA-0003387 (VISION OPEN 2024) AND CONTROL NUMBER 3387-1531. THE PURPOSE OF THIS AWARD IS TO DEVELOP AN ULTRA-CONDUCTIVE CARBON ALUMINUM COMPOSITE (UCAC) CABLE WITH SUPERIOR ELECTRICAL AND MECHANICAL PERFORMANCE FOR USE IN POWER TRANSMISSION AND DISTRIBUTION LINES TO RELIABLY AND EFFICIENTLY TRANSPORT ELECTRICITY.

OPTIMIZING NAVIGATION FOR RURAL ADVANCED MANUFACTURING PATHWAYS (ONRAMP)

RURAL COMMUNITIES OPIOID RESPONSE PROGRAM ? MENTAL AND BEHAVIORAL HEALTH - ABSTRACT 1. PROJECT TITLE COMMUNITY OF PRACTICE RESPONSE TO BEHAVIORAL HEALTH CARE SUPPORT IN RURAL OHIO 2. REQUESTED AWARD AMOUNT $2,000,000 3. APPLICANT ORGANIZATION NAME OHIO UNIVERSITY’S VOINOVICH SCHOOL OF LEADERSHIP & PUBLIC SERVICE 4. APPLICANT ORGANIZATION ADDRESS 1 OHIO UNIVERSITY; BLDG. 21, THE RIDGES; ATHENS, OH 45701 5. APPLICANT ORGANIZATION FACILITY TYPE INSTITUTION OF HIGHER LEARNING 6. PROJECT DIRECTOR NAME & TITLE HOLLY JANE RAFFLE, PROFESSOR 7. PROJECT DIRECTOR CONTACT INFORMATION 740-597-1710 RAFFLE@OHIO.EDU 8. DATA COORDINATOR NAME & TITLE NICOLE R. YANDELL, RESEARCH ASSOCIATE 9. DATA COORDINATOR CONTACT INFORMATION 740-597-1755 YANDELL@OHIO.EDU 10. EIN/DUNS NUMBER EXCEPTION REQUEST IN ATTACHMENT 8? NO 11. HOW THE APPLICANT FIRST LEARNED ABOUT THE FUNDING OPPORTUNITY HRSA PROJECT OFFICER 12. NUMBER OF CONSORTIUM MEMBERS & LIST OF CONSORTIUM MEMBERS 6 OHIO UNIVERSITY’S VOINOVICH SCHOOL OF LEADERSHIP & PUBLIC SERVICE PACIFIC INSTITUTE FOR RESEARCH AND EVALUATION ASHTABULA COUNTY MENTAL HEALTH AND RECOVERY SERVICES BOARD FAIRFIELD COUNTY ALCOHOL, DRUG ADDICTION, MENTAL HEALTH AND RECOVERY BOARD MENTAL HEALTH AND RECOVERY SERVICES BOARD OF SENECA, OTTAWA, SANDUSKY, AND WYANDOT COUNTIES SANDUSKY COUNTY HEALTH DEPARTMENT 13. IS THE APPLICANT ORGANIZATION A PREVIOUS OR CURRENT RCORP AWARD RECIPIENT OR CONSORTIUM MEMBER? YES FY18 RCORP-P, FY19 RCORP-I, FY21 RCORP-PS 14. INDICATE IF APPLICANT ORGANIZATION INTENDS TO APPLY FOR FY22 RCORP- I? NO 15. DOES THE TARGET SERVICE AREA OVERLAP WITH THE SERVICE AREAS OF THE NORTHERN BORDER REGIONAL COMMISSION, THE DELTA REGIONAL AUTHORITY, OR THE APPALACHIAN REGIONAL COMMISSION? YES ASHTABULA COUNTY IS IN THE ARC SERVICE AREA. 16. RCORP-BHS TARGET SERVICE AREA: A. FULLY RURAL COUNTIES: SANDUSKY COUNTY OH, SENECA COUNTY OH; ASHTABULA COUNTY OH B. PARTIALLY-RURAL COUNTIES: FAIRFIELD COUNTY (OH): 39045030900 39045031000 39045031100 39045031200 39045031300 39045031400 39045031500 39045031600 39045031700 39045032000 39045032100 39045032200 39045032300 39045032500 17. TARGET POPULATION THE PERCENTAGE OF THE TARGET POPULATION THAT IS NATIVE AMERICAN IN THE RURAL SERVICE AREA IS: ASHTABULA COUNTY (0.10%), FAIRFIELD COUNTY (0.10%), SENECA COUNTY (0.20%), AND SANDUSKY COUNTY (0.30%). THIS PROJECT DOES NOT SPECIFICALLY TARGET TRIBAL POPULATIONS. THE COMMUNITY OF PRACTICE RESPONSE TO BEHAVIORAL HEALTH CARE SUPPORT IN RURAL OHIO WILL CONTINUE A HIGHLY INNOVATIVE APPROACH THAT EMPOWERS LOCAL COMMUNITY CONSORTIUM FROM FOUR RURAL OHIO COMMUNITIES TO WORK TOGETHER TO IMPROVE ACCESS TO AND QUALITY OF SUBSTANCE USE DISORDER (SUD) AND OTHER BEHAVIORAL HEALTH (BH) CARE SERVICES. AS AN EXTENSION OF PREVIOUS RCORP-PLANNING AND RCORP-IMPLEMENTATION AWARDS, THIS PROJECT WILL SUPPORT THE ASHTABULA COUNTY SUBSTANCE ABUSE LEADERSHIP TEAM, THE FAIRFIELD COUNTY OPIATE TASK FORCE, AND THE SENECA COUNTY OPIATE TASK FORCE (WITH SUPPORT FROM THE SANDUSKY COUNTY HEALTH PARTNERS) IN IMPLEMENTING ACTIVITIES ALIGNED WITH THE THREE GOALS SET FORTH BY THE RURAL COMMUNITIES OPIOID RESPONSE PROGRAM –BH CARE SUPPORT INITIATIVE. THE GOALS OF THE PROJECT ARE TO: (1) ADDRESS STRUCTURAL- AND SYSTEMS-LEVEL BARRIER TO IMPROVE RURAL RESIDENT’S ACCESS TO QUALITY, INTEGRATED SUD AND OTHER BH CARE SERVICES; (2) IMPROVE THE QUALITY AND SUSTAINABILITY OF RURAL BH CARE SERVICES THROUGH SUPPORTING RURAL HEALTH CARE PROVIDERS TO OFFER COORDINATED, EVIDENCE-BASED, TRAUMA-INFORMED SUD AND OTHER BH CARE SERVICES; AND (3) IMPROVE THE CAPACITY OF THE BH CARE SYSTEM TO ADDRESS RURAL COMMUNITY RISK FACTORS AND SOCIAL DETERMINANTS OF HEALTH THAT AFFECT THE BH OF RURAL RESIDENTS. THROUGH A COMMUNITY OF PRACTICE APPROACH, OHIO UNIVERSITY’S VOINOVICH SCHOOL OF LEADERSHIP AND PUBLIC SERVICE, IN COLLABORATION WITH THE PACIFIC INSTITUTE FOR RESEARCH AND EVALUATION, WILL SUPPORT THE LOCAL CONSORTIA WITH TRAINING AND TECHNICAL ASSISTANCE TO ENSURE THE PROJECT’S GOALS ARE MET

ELECTROCHEMICAL-ENABLED CARBON DIOXIDE MINERALIZATION (E-CO2M) OF NATURAL BRINES AND WASTES TO ENABLE CARBON-NEGATIVE VALUE-ADDED PRODUCTS

GROWTH HORMONE REGULATING CHONDROCYTE METABOLISM FOR OSTEOARTHRITIS DEVELOPMENT - PROJECT SUMMARY MOST OLDER ADULTS (~60 YEARS OF AGE) HAVE SOME SIGNS OF OSTEOARTHRITIS (OA) IN THEIR JOINTS. UNFORTUNATELY, THERE ARE NO DISEASE-MODIFYING THERAPIES FOR OA DUE TO OUR LACK OF INSIGHT INTO THE UNDERLYING PATHOPHYSIOLOGY. GH IS AN FDA APPROVED DRUG TO TREAT CERTAIN DISEASES SUCH AS GROWTH HORMONE DEFICIENCY (GHD). ADDITIONALLY, GH SECRETION DECREASES OVER TIME, CAUSING SOME OLDER ADULTS TO CONSIDER THE USE OF GH REPLACEMENT AS A MEANS TO COUNTERACT AGING RELATED CONDITIONS. HOWEVER, OVER-PRODUCTION OR PROLONGED USAGE OF GH HAS BEEN REPORTED TO HAVE MANY SIDE EFFECTS INCLUDING JOINT DEGENERATION AND JOINT PAIN. IDENTIFYING THE MECHANISMS BY WHICH GH CAUSES JOINT CELL DYSFUNCTION DURING AGING COULD INFORM EFFECTIVE INTERVENTIONS AND THERAPEUTIC STRATEGIES THAT REDUCE THE INCIDENCE AND IMPACT OF OA. OUR PRELIMINARY STUDIES HAVE SHOWN THAT OVER-EXPRESSION OF GH GENE IN MICE PREDISPOSE MICE INTO PROGRESSIVE JOINT DEGENERATION, WHILE BLOCKING GH ACTION THROUGH SYSTEMIC GH RECEPTOR DISRUPTION PROTECT MICE FROM DEVELOPING OA. WE SHOWED THAT GH ROBUSTLY ALTERED THE METABOLISM OF CELLS (I.E, CHONDROCYTES) IN CARTILAGE. YET, IT IS STILL UNKNOWN IF BLOCKING GH’S ACTION SPECIFICALLY ON CARTILAGE TISSUE WOULD BE PROTECTIVE. GUIDED BY OUR PRELIMINARY DATA AND THE LITERATURE, WE WILL INVESTIGATE THIS QUESTION VIA THREE SPECIFIC AIMS: AIM 1. DETERMINE HOW BLOCKING GH ACTION ON CARTILAGE THROUGH CARTILAGE SPECIFIC DELETION OF GHR AFFECTS OA DEVELOPMENT; AIM 2. DETERMINE THE MECHANISMS BY WHICH GH PROMOTES CHONDROCYTE HYPERTROPHIC CHANGES AND OA DEVELOPMENT. AIM 3. DETERMINE IF GH RECEPTOR ANTAGONISM (GHA) PROTECTS MICE FROM DEVELOPING OA. WELL-ESTABLISHED MOUSE MODELS GH OVER-EXPRESSION AND GH RECEPTOR TISSUE SPECIFIC DELETION WILL BE USED TO EXAMINE THE CONSEQUENCES OF ENHANCING OR INHIBITING GH ACTION IN CARTILAGE ON OA PATHOLOGY. IN VIVO AND IN VITRO METABOLIC PROFILING METHODS WILL BE LEVERAGED TO DETERMINE THE EFFECTS OF MANIPULATING GH SIGNALING ON CHONDROCYTE CELLULAR METABOLISM. LAST BUT NOT LEAST, A UNIQUE MOUSE MODEL THAT WAS USED FOR DISCOVERY OF PEGVISOMANT, AN FDA APPROVED DRUG FOR TREATING ACROMEGALY, WILL BE USED TO TEST IF BLOCKING GH IS BENEFICIAL FOR JOINT HEALTH. SUCCESSFUL COMPLETION OF THIS RESEARCH IS EXPECTED TO PROVIDE MORE COMPREHENSIVE UNDERSTANDING OF HOW GH AFFECTS JOINT CELL FUNCTIONS, OFFERING THE POTENTIAL TO PROVIDE NEW THERAPEUTIC TARGETS FOR OA TREATMENT.

COMBINED NITROGEN AND PHOSPHOROUS RECOVERY VIA ELECTROCHEMICAL TECHNOLOGY INTEGRATION INTO MUNICIPAL WASTEWATER TREATMENT PLANTS

NEW AWARD FOR PROJECT ENTITLED "OHIO BIOREFINERY PROJECT"

TREATING COMPLEX SENTENCES IN CHILDREN WITH DLD - ABSTRACT CHILDREN INCREASINGLY CONFRONT COMPLEX SENTENCES AS THEY PROGRESS THROUGH THE SCHOOL YEARS. SENTENCE STRUCTURES INCLUDING PASSIVES AND RELATIVE CLAUSES ARE SPECIFICALLY MENTIONED IN SCHOOL CURRICULAR STANDARDS, AND CHILDREN ENCOUNTER THESE IN THE CONTEXT OF CONVERSATIONS, BOOKS, AND MOVIES. FOR THE 7-13% OF CHILDREN WITH A DEVELOPMENTAL LANGUAGE DISORDER, THE CHALLENGE POSED BY COMPLEX SENTENCE COMPREHENSION AND USE CAN CONTRIBUTE TO POOR ACADEMIC ACHIEVEMENT AND NEGATIVE SOCIAL INTERACTIONS. YET THE BULK OF ORAL LANGUAGE TREATMENT FOCUSES ON VOCABULARY GROWTH AND GRAMMATICAL MORPHEME ERRORS IN THE PRESCHOOL YEARS, WITH SCANT ATTENTION TO LATER-DEVELOPING LANGUAGE SKILLS. THIS GRANT PROPOSES TO COMPARE TWO ENTIRELY NEW TREATMENTS FOR COMPLEX SYNTAX. TWO RANDOMIZED CLINICAL TRIALS WILL TEST THE EFFECTS OF PHILOSOPHICALLY CONTRASTIVE TREATMENT APPROACHES THAT REPRESENT OPPOSING POINTS ON AN EXPLICIT-TO-IMPLICIT CONTINUUM OF LANGUAGE INTERVENTION. WE HYPOTHESIZE THAT TREATMENT METHODS IN WHICH CHILDREN ARE TAUGHT TO EXPLICITLY APPLY SYNTACTIC RULES WILL PRODUCE HIGH IN-TREATMENT PERFORMANCE, BUT AT THE COST OF THE AUTOMATIC, IMPLICIT KNOWLEDGE REQUIRED FOR RAPID AND UNCONSCIOUS APPLICATION TO UNTRAINED LINGUISTIC CONTEXTS. CONVERSELY, TREATMENT INTENDED TO FACILITATE IMPLICIT LEARNING OF SYNTACTIC FORMS WILL RESULT IN INCREMENTAL IN-TREATMENT GAINS BUT WILL ULTIMATELY RESULT IN A MORE GENERATIVE KNOWLEDGE AND USE OF COMPLEX SYNTACTIC FORMS. WE SEEK TO REPLICATE FINDINGS BY CONDUCTING SEPARATE CLINICAL TRIALS FOR THE TREATMENT OF PASSIVE SENTENCES AND SENTENCES WITH RELATIVE CLAUSES. IN ADDITION TO SUPPLYING CLINICIANS WITH MUCH NEEDED INFORMATION CONCERNING TREATMENT EFFECTIVENESS, THE DATA WILL PROVIDE AN IMPORTANT THEORETICAL TEST OF CAUSAL COMPONENTS OF OUR RECENTLY DEVELOPED MODEL OF COMPLEX SENTENCE COMPREHENSION AND USE IN CHILDREN WITH DEVELOPMENTAL LANGUAGE DISORDER. HEALTH RELEVANCE THE GRANT PROPOSES TO TEST NEW TREATMENTS FOR COMPLEX SENTENCE KNOWLEDGE AND USE, FOR WHICH THERE IS LITTLE IN THE WAY OF EFFECTIVE INTERVENTION. THE GRANT WILL DIRECTLY TEST THE EFFICACY OF TWO APPROACHES TO LANGUAGE TREATMENT (EXPLICIT TRAINING OF LANGUAGE RULES VS. IMPLICIT LEARNING OF SYNTACTIC STRUCTURES) AND WILL ASSESS DIFFERENT MODELS OF THE CAUSAL RELATIONSHIPS AMONG COGNITIVE FACTORS AND TREATMENT OUTCOMES.

1/2-MULTISITE STUDY OF SCHOOL BASED TREATMENT APPROACHES FOR ADHD ADOLESCENTS

DEVELOPING AND EVALUATING PROCESSES FOR THE DISSEMINATION OF EFFECTIVE UNIVERSAL AND TARGETED CLASSROOM MANAGEMENT PRACTICES

CEACAM1: A LINK BETWEEN METABOLIC AND CARDIOVASCULAR DISEASES

UPWARD BOUND

IDENTIFYING A NOVEL PLAYER IN SKELETAL MUSCLE PERFORMANCE AND METABOLISM - PROJECT ABSTRACT SKELETAL MUSCLE (SKM) FUNCTION AND STRENGTH, AND INTRINSIC MUSCLE QUALITY ARE CLOSELY LINKED TO THE PATHOGENESIS AND PATHOPHYSIOLOGY OF METABOLIC DISEASE. HOWEVER, THE REGULATORY MOLECULAR MECHANISMS IN SKM PERFORMANCE REMAIN ELUSIVE. THE CURRENT PROPOSAL WILL FOCUS ON IDENTIFYING NOVEL MOLECULAR PATHWAYS REGULATING MUSCLE FUNCTION AND INSULIN SIGNALING VIA THE MUSCLE-SPECIFIC ROLE OF FAT SPECIFIC PROTEIN 27 (FSP27). WHILE THE ADIPOCYTE ACTIONS OF FSP27 HAVE BEEN WELL-RECOGNIZED IN THE METABOLIC FIELD, WE UNEXPECTEDLY DISCOVERED HIGH FSP27 PROTEIN EXPRESSION IN SKM. OUR PRELIMINARY DATA IN HUMANS IDENTIFIED A POSITIVE CORRELATION OF SKM FSP27 EXPRESSION WITH INDICES OF MUSCLE PERFORMANCE SUCH AS AEROBIC CAPACITY, MUSCLE STRENGTH, AND RESPONSIVITY TO EXERCISE TRAINING. ALSO, OUR STUDY IN WHOLE-BODY FSP27-/- MICE DISPLAYED SEVERELY IMPAIRED MUSCLE ENDURANCE, MUSCLE STRENGTH, AND LOSS OF FAT IN THE SKM. INTRAMYOCELLULAR FAT IS A CRUCIAL SOURCE TO MEET THE ENERGY DEMAND IN THE SKM FOR ITS FUNCTION. THEREFORE, WE HYPOTHESIZED THAT FSP27 PLAYS A MAJOR ROLE IN MUSCLE PERFORMANCE AND INSULIN SENSITIVITY PRIMARILY VIA ITS ROLE IN REGULATING FAT HANDLING IN THE SKM. AS A FIRST STEP IN UNDERSTANDING THE CLINICAL RELEVANCE OF FSP27 IN SKM INSULIN SIGNALING AND MUSCLE FUNCTION, WE HAVE GENERATED AN INNOVATIVE GAIN-OF-FUNCTION TRANSGENIC MOUSE MODEL EXPRESSING THE HUMAN-FSP27 TRANSGENE, (M-FSP27TG), SPECIFICALLY IN SKM WITHOUT ALTERING THE EXPRESSION OF ENDOGENOUS MOUSE FSP27. ALSO, WE HAVE GENERATED A LOSS-OF-FUNCTION MUSCLE MODEL THROUGH MUSCLE-SPECIFIC ABLATION OF FSP27 (M-FSP27-/-). OUR PRELIMINARY STUDIES IN THESE MOUSE MODELS ARE IN-LINE WITH OUR HYPOTHESIS AND SUGGEST A CRITICAL ROLE OF SKM-SPECIFIC FSP27 IN MUSCLE PERFORMANCE. WE WILL UTILIZE A THREE-PRONGED APPROACH TO IDENTIFY THE PHYSIOLOGICAL AND MOLECULAR MECHANISM OF FSP27-MEDIATED SKM FUNCTION. IN AIM 1, WE WILL STUDY THE PHYSIOLOGICAL ACTION OF FSP27 IN SKM PERFORMANCE, AND ITS ROLE IN PROTECTION AGAINST OBESITY-INDUCED WHOLE-BODY INSULIN RESISTANCE. IN AIM 2, WE WILL TEST OUR HYPOTHESIS THAT FSP27 HANDLES INTRAMYOCELLULAR FAT FUEL VIA ITS ACTION ON THE MOTOR ACTIVITY OF THE CYTOSKELETAL PROTEINS ALONG THE FSP27-RAB18-P150-DYENIN AXIS IN THE SKM. IN AIM 3, WE WILL TEST OUR HYPOTHESIS THAT IN ADDITION TO ITS EFFECT ON CYTOSKELETON MOTOR ACTIVITY, FSP27 REGULATES EXERCISE ENDURANCE AND INSULIN SENSITIVITY VIA THE GLUCAGON-LIKE PEPTIDE 1 RECEPTOR (GLP1R)-AMPK PATHWAY. A STRENGTH OF THIS PROPOSAL IS AN INTERDISCIPLINARY COLLABORATION FORMED BETWEEN DR. PURI (EXPERT IN BASIC AND TRANSLATIONAL RESEARCH IN LIPID METABOLISM AND SIGNALING), DR. CONSITT (EXPERT IN SKM METABOLISM), DR. BAUMANN (EXPERT IN SKM PHYSIOLOGY), AND DR. LEE (EXPERT IN TISSUE INSULIN SIGNALING), WHICH WILL UTILIZE THEIR COMPLEMENTARY EXPERTISE AND BUILD UPON THEIR COLLABORATIVE WORK IN THIS PROJECT. SUCCESSFUL COMPLETION OF THE PROPOSED STUDIES WILL IDENTIFY A NOVEL REGULATORY PLAYER IN SKM PERFORMANCE AND MUSCLE BIOLOGY.

OHIO UNIVERSITY TRAINING PROJECT GRANT IN OCCUPATIONAL SAFETY

BRIDGING SCIENCE AND PRACTICE FOR STUDENTS WITH EMOTIONAL AND BEHAVIORAL PROBLEMS

MOLECULAR MECHANISMS OF CNOS-MEDIATED NF-KAPPA B ACTIVATION IN REGULATION OF ULTRAVIOLET B LIGHT-INDUCED PHOTOCARCINOGENIC RESPONSES

LOW-GRADE INFLAMMATION, CYTOKINES, AND BETA-CELL DYSFUNCTION IN TYPE 2 DIABETES

IMPROVE EXISTING AIRPORT

STEM+ FOR ALL

STUDENT SUPPORT SERVICES PROGRAM

STUDENT SUPPORT SERVICES PROGRAM

TREATMENT OF PRODUCED WATER FOR BENEFICIAL USE WITH CONCURRENT RESOURCE RECOVERY UTILIZING COAL- AND WASTE COAL-DERIVED MATERIALS. THIS PROJECT WILL DEVELOP A PROCESS TO RENDER TREATMENT OF OIL AND GAS PRODUCED WATER FOR BENEFICIAL USE OUTSIDE OF THE OIL AND GAS INDUSTRIES ECONOMICALLY FEASIBLE BY 1) CHARACTERIZING PRODUCED WATER SUPPLIED FROM SPECIFIC SITES, INCLUDING SITES IN THE MARCELLUS AND UTICA AREAS.

SPECIAL EDUCATION RESEARCH

SPF-PFS COMMUNITY OF PRACTICE IN SOUTHEASTERN OHIO

PURPOSE/SCOPE: THE DIGITAL DESIGN STUDIO (DDS) AT THE UNIVERSITY OF DAYTON'S DIGITAL TRANSFORMATION CENTER SEEDLING WILL BE OPERATED BY OHIO UNIVERSITY. THE DDS WILL UTILIZE APPROXIMATELY 2547 SF OF THE DIGITAL TRANSFORMATION CENTER (DTC) SEEDLING. THE DTC IS LOCATED ON THE SECOND FLOOR OF A TWO-STORY BUILDING OWNED BY THE UNIVERSITY OF DAYTON. A MAJOR PORTION OF THIS AWARD (~$1.3 MILLION) WILL BE UTILIZED FOR EQUIPPING THE DDS SPACE WITH DIGITAL ENGINEERING EQUIPMENT AND THE SOFTWARE NEEDED TO RUN IT. THIS EQUIPMENT WILL INCLUDE COMPUTERS, VIDEO SCREENS, ROUTERS, FIREWALLS, AUGMENTED/VIRTUAL REALITY SYSTEMS, AND WORKSTATION / FURNITURE UNITS. IN ADDITION, THESE COMPUTER SYSTEMS WILL REQUIRE SOFTWARE TO MAKE THEM USEFUL. THESE SOFTWARE ACQUISITIONS ARE A NECESSARY AND INTEGRAL PART OF ENABLING THE DDS EQUIPMENT TO PRODUCE THE DESIRED OUTCOMES AND GOALS FOR THE PROJECT.ACTIVITIES TO BE PERFORMED: THE DIGITAL DESIGN STUDIO (DDS) WILL BE COMPRISED OF FOUR MAIN THRUSTS:1) ACCELERATING SYSTEMS DEVELOPMENT THROUGH THE USE OF MODEL-BASED SYSTEMS ENGINEERING EMPHASIZING THE USE OF DIGITAL DESIGN AND AGILE SOFTWARE DEVELOPMENT METHODS CREATING DIGITAL TWINS/DIGITAL THREADS OF PRODUCTS WHICH CAN BE RAPIDLY PRODUCED USING ADVANCED MANUFACTURING METHODS.2) TRAINING THE CURRENT WORKFORCE IN THESE NEW METHODS.3) EDUCATING COLLEGE STUDENTS IN THE USE AND APPLICATION OF DIGITAL TOOLS PREPARING THEM FOR FUTURE WORKFORCE NEEDS.4) PROVIDING A FACILITY FOR INDUSTRY, ACADEMIA, AND GOVERNMENT TO COLLABORATE AND LEARN TO APPLY AND USE DIGITAL TOOLS.EXPECTED OUTCOMES: TODAY, THE MILITARY'S WEAPONS PROGRAMS TAKE TWO TO THREE-TIMES LONGER TO MOVE FROM INITIATION TO DEPLOYMENT THAN INDUSTRY BEST PRACTICES. IN ORDER TO MAINTAIN THE UNITED STATES' TECHNOLOGICAL SUPERIORITY, WE MUST ACCELERATE THE ADOPTION OF BETTER MODEL-BASED SYSTEMS ENGINEERING, USING THE LATEST DIGITAL DESIGN, MANUFACTURING AND INFORMATION MANAGEMENT TOOLS TO SHORTEN THE TIME FOR DEVELOPMENT AND DRAMATICALLY REDUCE COST. RAPID PRODUCT DEVELOPMENT USING THESE TOOLS WILL FACILITATE CONTINUOUS IMPROVEMENTS ENABLING A CONSTANT STREAM OF PRODUCT AND SERVICE IMPROVEMENTS.INTENDED BENEFICIARIES:INTEGRATED HIGH-FIDELITY MODELLING AND SIMULATION WILL ALLOW BUSINESS, INDUSTRY AND OUR MILITARY TO RAPIDLY MATURE SCIENCE AND TECHNOLOGY WHILE DEVELOPING ENGINEERS WHO CAN OPERATE IN THE DYNAMIC DESIGN/BUILD/SUSTAIN ENVIRONMENT NECESSARY TO INTEGRATE SYSTEMS AND TRANSITION NEW CAPABILITIES TO THE FIELD IN ORDER TO MAINTAIN THE UNITED STATES' TECHNICAL SUPERIORITY IN THE 21ST CENTURY.SUBRECIPIENT ACTIVITIES: NONE

NOVEL GLYCOGEN SYNTHASE KINASE-3 (GSK-3) INHIBITORS AS THERAPEUTIC AGENTS

TARGETING A NOVEL REGULATORY RNA WITH NOVEL ANTIBIOTICS

BOBCAT NETWORK

NEURAL MECHANISMS OF DYNAPENIA

NEW AWARD DE-FE0031809, UNIVERSITY OF OHIO, TITLED ''DIRECT UTILIZATION OF UNITED STATES COAL AS FEEDSTOCK FOR THE MANUFACTURE OF HIGH-VALUE COAL PLASTIC COMPOSITES.''

UPWARD BOUND PROGRAM

SINGLE ATOM AND MOLECULE MANIPULATION AND ITS APPLICATION TO NANOSCIENCE AND NANOTECHNOLOGY

ADVANCED EDUCATION NURSING TRAINEESHIP

TRIO - STUDENT SUPPORT SERVICES - STUDENT SUPPORT SERVICES PROGRAM

BIOTECH LAB INCUBATOR

TAS::89 0321::TAS CDP TRACKING NO. OE 163.10 - NEW AWARD TO OHIO UNIVERSITY - MULTI-HYBRID POWER VEHICLES WITH COST EFFECTIVE AND DURABLE POLYMER ELE

MRI: ACQUISITION OF TRANSMISSION ELECTRON MICROSCOPE FOR ADVANCED MATERIALS RELATING TO ENERGY STORAGE, ALTERNATIVE ENERGY, REMEDIATION, AND SUPERCON

INFRATRUCTURE UPGRADES

THIS PROPOSAL COVERS THE DESIGN, DEVELOPMENT, VERIFICATION AND VALIDATION OF A PERFORMANCE-BASED FLIGHT DECK INFORMATION MANAGEMENT SYSTEM TO IMPROVE

CAREER: THE ROLE OF F-BOX-MEDIATED PROTEIN DEGRADATION IN SEED DEVELOPMENT

TRACK 1, GK-12: SCIENCE AND TECHNOLOGY ENRICHMENT FOR APPALACHIAN MIDDLE-SCHOOLERS (STEAM)

EDUCATION & WORKFORCE DEVELOPMENT

UV-INDUCED AND NOS-MEDIATED ZN ELEVATION, TRANSLATION REGULATION AND APOPTOSIS

NATIONAL RESOURCE CENTERS AND FELLOWSHIPS PROGRAM FOR LANGUAGE AND AREA OR LANGUAGE AND INTERNATIONAL STUDIES - FOREIGN LANGUAGE AND AREA STUDIES FEL

PREVENTING ADVERSE REACTIONS IN NOVICE BLOOD DONORS

CIDE PROTEINS AND REGULATION OF ENERGY EXPENDITURE

COLLABORATIVE RESEARCH: APPARATUS FOR NORMALIZATION AND SYSTEMATIC CONTROL OF THE MOLLER EXPERIMENT

FOREIGN LANGUAGE AND AREA STUDIES FELLOWSHIPS

ULTRA-CONDUCTIVE CARBON METAL COMPOSITE WIRE FOR ELECTRIC MOTORS THE OBJECTIVE OF THIS PROJECT IS TO DEVELOP COST-EFFECTIVE CARBON-METAL COMPOSITE MATERIALS WITH ENHANCED BULK ELECTRICAL PROPERTIES FOR USE IN ELECTRIC MOTORS TO INCREASE AMERICAN ENERGY EFFICIENCY AND REDUCE GREENHOUSE GAS EMISSIONS.

NEW AWARD TO: OHIO UNIVERSITY AWARD NUMBER: DE-FE0032144 PROJECT TITLED: UTILIZATION OF CARBON SUPPLY CHAIN WASTES AND BYPRODUCTS TO MANUFACTURE GRAPHITE FOR ENERGY STORAGE APPLICATIONS

COLLABORATIVE RESEARCH: DESC: TYPE II: MULTI-FUNCTION CROSS-LAYER ELECTRO-OPTIC FABRICS FOR RELIABLE AND SUSTAINABLE COMPUTING SYSTEMS -WITH THE EXPLOSION OF COMPUTING DEVICES AND SYSTEMS IN EVERYDAY CONSUMER ELECTRONICS, THE AMOUNT OF ENERGY REQUIRED TO POWER INFORMATION AND COMPUTING TECHNOLOGIES (ICT) IS REACHING CLOSE TO 5% OF WORLDWIDE CARBON EMISSIONS. EMBODIED EMISSIONS ORIGINATE FROM THE MANUFACTURING OF HARDWARE AND FROM INFRASTRUCTURE-RELATED ENERGY SUCH AS PROCUREMENT OF RAW MATERIALS, FABRICATION, PACKAGING, AND ASSEMBLY. THIS IS DISTINCT FROM OPERATIONAL ENERGY, WHICH STEMS FROM USING THE HARDWARE. SUSTAINABILITY IN COMPUTING SHOULD BE BASED ON THREE UNIVERSALLY ACCEPTED TENETS ? REUSE, REDUCE AND RECYCLE ? OF HARDWARE COMPONENTS AND SYSTEMS. FROM A SUSTAINABILITY PERSPECTIVE, WE NEED TO REUSE OR REPURPOSE EXISTING HARDWARE PLATFORMS FOR MULTIPLE FUNCTIONALITIES TO REDUCE EMBODIED EMISSIONS, RECYCLE HARDWARE TO EXTEND OR PROLONG LIFETIME RELIABILITY, AND REDUCE THE OPERATIONAL OR USE-PHASE ENERGY REQUIRED OF THE HARDWARE PLATFORM. THEREFORE, FUTURE HARDWARE PLATFORMS BASED ON CHIPLETS, - SMALL, INTEGRATED CIRCUITS WITH DEFINED FUNCTIONS - SHOULD BE CAREFULLY DESIGNED TO BALANCE POWER, PERFORMANCE, AND RELIABILITY WHEN DESIGNED FOR SUSTAINABILITY. THIS RESEARCH PROJECT ESTABLISHES VERY IMPORTANT CONNECTIONS BETWEEN ELECTRONIC COMPUTING SYSTEMS, PHOTONIC TECHNOLOGY, COMPUTER ARCHITECTURE, MACHINE LEARNING, AND SUSTAINABILITY REQUIREMENTS. THE RESEARCH WILL FOSTER NEW RESEARCH DIRECTIONS IN SEVERAL AREAS, SPANNING COMPUTER ARCHITECTURE, SILICON PHOTONICS, ALGORITHMS, AND APPLICATIONS, WITH THE POTENTIAL TO SIGNIFICANTLY TRANSFORM THE DESIGN OF NEXT-GENERATION SUSTAINABLE CHIPLET-BASED HETEROGENOUS COMPUTING SYSTEMS. ALL THE RESEARCH FINDINGS AND SIMULATION RESULTS WILL BE SHARED WITH THE COMMUNITY VIA CONFERENCE/JOURNAL PUBLICATION, PROFESSIONAL MEETINGS, AND A DEDICATED WEBSITE. THE TEAM IS COMMITTED AND WILL CONTINUE TO EXPAND ON OUTREACH ACTIVITIES, EDUCATION, TRAINING, AND BROADENING PARTICIPATION IN COMPUTING AS PART OF THE PROJECT BY MAKING THE NECESSARY EFFORTS TO ATTRACT AND TRAIN MINORITY STUDENTS IN THIS FIELD. THIS RESEARCH WILL DESIGN MULTI-FUNCTIONAL, SELF-HEALING AND CROSS-LAYER OPTIMIZED ELECTRO-OPTIC FABRIC FOR COMPUTING ARCHITECTURES AND ACCELERATORS TO IMPROVE RELIABILITY, PERFORMANCE AND SUSTAINABILITY. THE OVERARCHING GOAL OF THE PROJECT IS TO ENHANCE THE SUSTAINABILITY OF COMPUTING SYSTEMS BY REDUCING THE IMPACT OF EMBODIED ENERGY AND EXTENDING THE OPERATIONAL LIFETIME OF HARDWARE SYSTEMS. THE TEAM WILL EXPLORE A COMBINATION OF ELECTRONICS AND SILICON PHOTONICS COMPREHENSIVELY AND SYSTEMATICALLY FOR BOTH COMMUNICATION AND COMPUTATION IN ONE INTEGRATED SYSTEM TO DRAMATICALLY IMPROVE PERFORMANCE-PER-WATT RESOURCE UTILIZATION, RELIABILITY, AND SUSTAINABILITY OF FUTURE COMPUTING SYSTEMS. THIS RESEARCH WILL RESULT IN (1) NOVEL ELECTRICAL AND PHOTONIC INTERCONNECT-BASED ARCHITECTURES THAT HAVE MULTIPLE FUNCTIONALITY FOR COMMUNICATION, COMPUTATION AND STORAGE, (2) SELF-HEALING AND FAULT-TOLERANT ELECTRICAL AND OPTICAL FABRIC THAT IMPROVE THE RELIABILITY OF THE HETEROGENEOUS COMPUTING CHIPLETS, (3) HARDWARE AND CROSS-LAYER TECHNIQUES TO DYNAMICALLY ADAPT TO APPLICATION DEMANDS TO REDUCE OPERATIONAL ENERGY, (4) AN EXTENSIVE MODELING AND SIMULATION FRAMEWORK FOR EVALUATING EMBODIED AND OPERATIONAL ENERGY OF THE PROPOSED ARCHITECTURES, AND (5) PROOF-OF-CONCEPT TESTBED IMPLEMENTATION. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

RURAL COMMUNITIES OPIOID RESPONSE-IMPLEMENTATION

DESIGN DEVELOPMENT. VERIFICATION AND VALI DATION OF AN INTEGRATED ALERTI

THE PRIMARY OBJECTIVE OF THIS PROJECT IS TO DEVELOP ENVIRONMENTALLY FRIENDLY AND COST-EFFECTIVE PROCEDURES TO SYNTHESIZE HIGH-VALUE CARBON QUANTUM DOTS AND GRAPHENE FOR SUPERCAPACITOR MATERIALS FROM COAL AND WASTE COAL.

NEW AWARD TO: OHIO UNIVERSITY AWARD NUMBER: DE-FE0032143 PROJECT TITLED: FUSED DEPOSITION MODELING ADDITIVE MANUFACTURING OF CARBONIZED STRUCTURES VIA WASTE-ENHANCED FILAMENTS

REHABILITATION 2.0: ADDRESSING NEUROPLASTICITY IN THE MUSCULOSKELETAL REHABILITATION MODEL

R15 AREA: OPTIMIZING ALLOSTERIC MODULATION OF NONCODING REGULATORY RNA FUNCTION

COLLABORATIVE RESEARCH: CONNECTING ELEMENTARY MATHEMATICS TEACHING TO REAL-WORLD ISSUES

THE BUPRENORPHINE PRESCRIBING SUPPORT PROGRAM FOR RURAL PRIMARY CARE - PROJECT SUMMARY/ABSTRACT: OUR COMMUNITY-ENGAGED STUDY WILL TEST WHETHER A BRIEF PRESCRIBING SUPPORT PROGRAM, PAIRED WITH MENTORSHIP FROM PEER HEALTH CARE PROFESSIONALS CAN EXPAND ACCESS TO BUPRENORPHINE IN RURAL COMMUNITIES AND IMPROVE CLINICAL OUTCOMES IN PEOPLE WITH OPIOID USE DISORDER (OUD). DESPITE ITS EFFICACY, BUPRENORPHINE IS VASTLY UNDERUSED IN RURAL SETTINGS AND IS NOT OFTEN PRESCRIBED BECAUSE OF STIGMA TOWARDS THE MEDICATION, LACK OF TRAINING, AND LIMITED OPPORTUNITIES FOR PEER MENTORSHIP. PRIMARY CARE PROFESSIONALS (PCPS) ARE AN IDEAL GROUP TO INCREASE BUPRENORPHINE AVAILABILITY. PRIMARY CARE IS A LESS STIGMATIZING CARE SETTING, AND PCPS CAN ALSO PROVIDE OTHER NEEDED MEDICAL CARE AS WELL AS INFECTIOUS DISEASE SCREENING. WE CO-CREATED THE BUPRENORPHINE PRESCRIBING SUPPORT PROGRAM (BPSP) WITH RURAL PCPS IN OHIO AND DETERMINED FEASIBILITY IN A PILOT CLINICAL TRIAL OF 29 FEDERALLY QUALIFIED HEALTH CENTERS. THE BPSP PAIRS CLINICAL TRAINING ON BUPRENORPHINE WITH STIGMA REDUCTION TO INCREASE CONFIDENCE PRESCRIBING THE MEDICATION. PCPS COMPLETING THE PROGRAM ALSO RECEIVE LONG-TERM PRESCRIBING SUPPORT SINCE MENTORSHIP IS LIMITED IN SMALL, RURAL PRIMARY CARE CLINICS. ALTHOUGH WE FOUND ENCOURAGING TRENDS IN OUR FEASIBILITY TRIAL, THE PILOT WAS NOT POWERED TO DETECT CHANGES IN ADOPTION. THE BPSP NEEDS TESTED IN A FULLY POWERED, HYBRID TYPE 3 CLUSTER RANDOMIZED IMPLEMENTATION EFFECTIVENESS TRIAL TO DETERMINE IF THE PROGRAM IMPROVES IMPLEMENTATION AS WELL AS CLINICAL OUTCOMES FOR PEOPLE WITH OUD. WE HAVE 3 AIMS: 1) IMPLEMENTATION: WE WILL ASSESS THE IMPACT OF THE BPSP ON BUPRENORPHINE ADOPTION AND REACH IN A CLUSTER RANDOMIZED HYBRID TYPE 3 IMPLEMENTATION EFFECTIVENESS TRIAL IN 40 RURAL PRIMARY CARE CLINICS IN OHIO AND WEST VIRGINIA; 2) CLINICAL EFFECTIVENESS: WE WILL DETERMINE THE LONG-TERM IMPACT OF THE BPSP ON CLINICAL OUTCOMES, INCLUDING PATIENT RETENTION IN CARE, REMISSION FROM OPIOID USE; AND INFECTIOUS DISEASE STATUS; AND 3) DETERMINANTS OF IMPLEMENTATION, SCALE-UP, AND SUSTAINMENT: USING IN-DEPTH INTERVIEWS WITH PCPS, STAFF, AND CLINIC LEADERSHIP, WE WILL EXPLORE BPSP IMPLEMENTATION BARRIERS AND FACILITATORS, IDENTIFY ANY FUTURE TAILORING NEEDS, AND SELECT APPROPRIATE STRATEGIES FOR SCALE UP AND DISSEMINATION BEYOND RURAL OHIO AND WEST VIRGINIA. BY INTEGRATING TAILORED PRESCRIBING SUPPORT WITHIN RURAL PRIMARY CARE TO BUILD THE BUPRENORPHINE PRESCRIBER WORKFORCE AND EXPAND ACCESS TO MEDICATION THAT CAN REDUCE OVERDOSE, OUR STUDY DIRECTLY ALIGNS WITH THE OBJECTIVES OUTLINED IN RFA-DA-25-077 TO END THE OVERDOSE CRISIS AND THE ASSOCIATED NOSI (NOT-DA-23- 008) TO BUILD THE ADDICTION CARE WORKFORCE. OUR STUDY WILL ADVANCE BOTH IMPLEMENTATION AND INTERVENTION SCIENCE. THE INCLUSION OF LARGE AND SMALL RURAL CLINICS IN TWO STATES WILL ENSURE THE FINDINGS ARE APPLICABLE TO PRIMARY CARE CLINICS THAT SERVE RURAL AREAS NATIONWIDE. THE BPSP HAS THE POTENTIAL TO BE A LOW-COST, SUSTAINABLE, AND SCALABLE PROGRAM THAT WILL IMPROVE BUPRENORPHINE ACCESS IN RURAL COMMUNITIES.

NATIONAL RESOURCE CENTERS AND FELLOWSHIPS PROGRAM FOR LANGUAGE AND AREA OR LANGUAGE AND INTERNATIONAL STUDIES - NATIONAL RESOURCE CENTERS

DEVELOPMENT OF ANALYTICAL AND CHEMOMETRIC METHODS FOR IDENTIFICATION AND AUTHENTICATION OF FOODS AND BOTANICAL SUPPLEMENTS - TO DEVELOP STRATEGIES FOR THE IDENTIFICATION AND AUTHENTICATION OF FOODS AND BOTANICAL SUPPLEMENTS USING NON-TARGETED ANALYTICAL METHODS AND CHEMOMETRIC ANALYSIS. NON-TARGETED METHODS WILL USE THE FULL SPECTRA FROM SIMPLE NEAR INFRARED (NIR) AND ULTRAVIOLET SPECTROPHOTOMETRY (UV) AND SOPHISTICATED MASS SPECTROMETRY (MS) AND NUCLEAR MAGNETIC RESONANCE (NMR) INSTRUMENTS TO ACQUIRE AS COMPLETE DATA AS POSSIBLE FOR BOTANICAL MATERIALS. THE COMPLEX SPECTRAL DATA WILL BE ANALYZED USING CONVENTIONAL AND NEW CHEMOMETRIC METHODS TO DETECT PATTERNS ASSOCIATED WITH EXPERIMENTAL PARAMETERS SUCH AS GENETICS, ENVIRONMENT, MANAGEMENT, AND PROCESSING. THE ANALYTICAL AND DATA PROCESSING STRATEGIES WILL BE USED TO DEVELOP GUIDELINES FOR VALIDATION OF BOTANICAL IDENTIFICATION METHODS AND WILL SERVE AS EXAMPLES FOR RESEARCHERS IN THE FIELD.

SINGLE ATOM AND MOLECULE MANIPULATION AND ITS APPLICATION TO NANOSCIENCE AND NANOTECHNOLOGY

SEP: SUSTAINABLE HOUSING THROUGH HOLISTIC WASTE STREAM MANAGEMENT AND ALGAL CULTIVATION

OPIOID WORKFORCE EXPANSION PROGRAM- PROFESSIONAL

CARBON-BASED MATERIALS FOR SUSTAINABLE BUILDING AND ENERGY APPLICATIONS

EFFECT OF SENSORINEURAL HEARING LOSS ON THE NEURAL CODING OF SPATIAL HEARING

RURAL HEALTH NETWORK DEVELOPMENT PROGRAM

STUDIES IN LOW ENERGY NUCLEAR SCIENCE

ENTREPRENEURAL DEV

SUPER-RESOLUTION OPTICAL MAPPING FOR DNA ANALYSIS USING TRIPLEX-FORMING OLIGONUCLEOTIDES AS STOCHASTIC MOLECULAR PROBES

NATIONAL RESOURCE CENTERS AND FELLOWSHIPS PROGRAM FOR LANGUAGE AND AREA OR LANGUAGE AND INTERNATIONAL STUDIES - NATIONAL RESOURCE CENTERS

OHIO UNIVERSITY SCATTERING AND REACTIONS OF LIGHT NUCLEI THIS RENEWAL AWARD IS INCREMENTALLY FUNDED IN THE AMOUNT OF $250,000 TO FULLY FUND BUDGET PERIOD 1 EFFECTIVE OCTOBER 1, 2018

PURPOSE: CONSTRUCT/EXPAND HANGAR. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT CONSTRUCTS A NEW 18,207 SQUARE FOOT SPONSOR-OWNED HANGAR FOR AIRCRAFT STORAGE TO ASSIST THE AIRPORT TO BE AS SELF-SUSTAINING AS POSSIBLE BY GENERATING REVENUE. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH ATHENS, OHIO.

USING PERTURBATION TO CHARACTERIZE AND BUILD MODELS OF INDIVIDUAL NEURONS

IMPROVE EXISTING AIRPORT C

FY 2016 STUDY OF THE U.S. INSTITUTES FOR SCHOLARS AND SECONDARY EDUCATORS

BIOMASS ELECTROCHEMICAL REACTOR FOR UPGRADING BIOREFINERY WASTE TO INDUSTRIAL CHEMICALS AND HYDROGEN

PROJECT TITLE: "STUDIES IN LOW-ENERGY NUCLEAR SCIENCE"

STUIDES IN LOW ENERGY NUCLEAR SCIENCE

MATERIALS WORLD NETWORK: COLLABORATIVE RESEARCH: DECOHERENCE, CORRELATIONS AND SPIN EFFECTS IN NANOSTRUCTURED MATERIALS

DE-FE0031709 PROJECT TITLED: ''NOVEL MODULAR ELECTROCATALYTIC PROCESSING FOR SIMULTANEOUS CONVERSION OF CARBON DIOXIDE AND WET SHALE GAS INTO VALUABLE PRODUCTS''

REGIONAL TRAINING CENTER FOR TROPICAL DISEASE RESEARCH IN QUITO-ECUADOR

DOCTORAL TRAINING OPPORTUNITIES FOR UNDERREPRESENTED US GRADUATE STUDENTS IN ELECTRICAL ENGINEERING AND COMPUTER SCIENCE

ADVANCED EDUCATION NURSING GRANTS

MECHANISMS OF AGE-RELATED IMPAIRMENTS IN HUMAN SKELETAL MUSCLE GLUCOSE METABOLISM - OVER THE NEXT 40 YEARS THE PERCENTAGE OF AMERICANS OVER THE AGE OF 65 WILL DRAMATICALLY INCREASE MEANING AN ALARMING NUMBER OF THEM WILL BE SUFFERING FROM INSULIN RESISTANCE AND TYPE 2 DIABETES. UNFORTUNATELY, THE CELLULAR MECHANISMS THAT CONTRIBUTE TO THESE METABOLIC DISTURBANCES IN OLDER ADULTS REMAIN UNKNOWN. THE LONG-TERM OBJECTIVE OF THIS RESEARCH IS TO IDENTIFY CELLULAR MECHANISMS IN SKELETAL MUSCLE THAT CONTRIBUTE TO INSULIN RESISTANCE, SO THAT EFFECTIVE TREATMENTS CAN BE DEVELOPED. THE CENTRAL HYPOTHESIS OF THIS PROJECT IS THAT INSULIN RESISTANCE IN OLDER ADULTS IS RELATED TO ELEVATED SKELETAL MUSCLE AS160-PROTEIN PHOSPHATASE 1A INTERACTION AND IMPAIRMENTS IN PHOSPHORYLATION OF GS SITE 2+2A, WHICH ARE ENHANCED DUE TO IMPAIRMENTS IN PDP1 REGULATION. THIS HYPOTHESIS HAS BEEN FORMULATED BASED ON PRELIMINARY DATA COLLECTED WITH UNDERGRADUATE STUDENTS IN THE APPLICANT’S LABORATORY. EXPERIMENTS WILL INCLUDE MECHANISTIC CELL CULTURE EXPERIMENTS IN PRIMARY HUMAN SKELETAL MUSCLE CELLS, AS WELL AS, CLINICAL EXPERIMENTS USING HUMAN SKELETAL MUSCLE BIOPSIES AND HYPERINSULINEMIC-EUGLYCEMIC CLAMP PROCEDURES. THE SPECIFIC AIMS OF THIS PROJECT ARE TO: 1) DETERMINE THE PROTEIN PHOSPHATASE RESPONSIBLE FOR IMPAIRED INSULIN-STIMULATED AS160 PHOSPHORYLATION IN HUMAN SKELETAL MUSCLE AND RELATED TO INSULIN RESISTANCE SENSITIVITY IN AGED ADULTS; 2) DETERMINE THE CELLULAR MECHANISM(S) RESPONSIBLE FOR IMPAIRED INSULIN-STIMULATED SKELETAL MUSCLE PDH DEPHOSPHORYLATION (ACTIVITY) IN AGED INDIVIDUALS AND ASSOCIATED WITH INSULIN RESISTANCE; 3) DETERMINE IF INSULIN-STIMULATED DEPHOSPHORYLATION OF SKELETAL MUSCLE GLYCOGEN SYNTHASE ON SITES 2+2A IS IMPAIRED IN AGED INDIVIDUALS AND RELATED TO INSULIN RESISTANCE. IT IS ANTICIPATED THESE STUDIES WILL REVEAL NEW INSIGHTS REGARDING THE CELLULAR MECHANISMS IN SKELETAL MUSCLE THAT CONTRIBUTE TO AGE-RELATED INSULIN RESISTANCE, AND PROVIDE THE FRAMEWORK FOR TARGETED AND EFFICIENT TREATMENT STRATEGIES IN THE NEAR FUTURE. IT WILL ALSO PROVIDE A UNIQUE OPPORTUNITY FOR STUDENTS TO BE EXPOSED TO TRANSLATIONAL BIOMEDICAL RESEARCH, AND THE OPPORTUNITY TO INCORPORATE METABOLISM/PHYSIOLOGY THEORIES LEARNED IN THE CLASSROOM TO CLINICAL AND BENCHTOP RESEARCH.

OPTIMAL AND ROBUST RECONSTRUCTION OF BAO, REDSHIFT-SPACE DISTORTIONS AND THE ALCOCK-PACZYNSKI EFFECT

BUSINESS TECHNICAL ASSISTANCE

SEOCEMS NOYCE SCHOLARSHIP PROGRAM: PHASE I

NURSE EDUCATION PRACTICE, QUALITY AND RETENTION

ADVANCED INTEGRATED TECHNOLOGIES FOR TREATMENT AND REUTILIZATION OF IMPAIRED WATER IN FOSSIL FUEL-BASED POWER PLANT SYSTEMS

TELEPHONE-DELIVERED COPING IMPROVEMENT INTERVENTION FOR HIV-INFECTED OLDER ADULTS

SPIN POLARIZED SCANNING TUNNELING A MICROSCOPY STUDIES OF NANOSCALE MAGNETIC AND SPINTRONIC NITRIDE SYSTEMS

IMPROVING DARK ENERGY CONTRAINTS USING LOW-REDSHIRT LARGE-SCALE STRUCTURES

DEVELOPING IMPLEMENTATION STRATEGIES TO IMPROVE ACCESS TO TRANSITIONAL OPIOID PROGRAMS IN SAFETY NET HOSPITALS - PROJECT SUMMARY/ABSTRACT: OPIOID USE DISORDER (OUD) IS A PRESSING PUBLIC HEALTH PROBLEM NATIONWIDE BUT IS INCREASING RAPIDLY IN UNDERSERVED COMMUNITIES WHERE THERE IS CURRENTLY A SHORTAGE OF SERVICES, PARTICULARLY EVIDENCE-BASED TRANSITIONAL OPIOID PROGRAMS (TOPS) WHICH LINK PATIENTS IN HOSPITALS TO HARM REDUCTION AND TREATMENT RESOURCES. HOSPITALS ARE IDEAL SITES TO ADDRESS OUD AND ENGAGE PATIENTS GIVEN THE RELATIONSHIP BETWEEN OPIOID USE AND MISUSE AND A NUMBER OF ACUTE HEALTH CONDITIONS, INCLUDING OVERDOSE AND INFECTIOUS DISEASE. EVIDENCE SUGGESTS THAT HOSPITALS ARE HIGHLY MOTIVATED TO PARTICIPATE IN OFFERING NEW INTERVENTIONS DUE TO THE ECONOMIC AND SOCIAL TOLL OF UNTREATED OUD. SAFETY NET HOSPITALS, HOWEVER, FACE CONSIDERABLE BARRIERS TO ADOPTING TOPS AND HAVE BEEN SIGNIFICANTLY LESS LIKELY TO OFFER OUD SERVICES IN THEIR COMMUNITIES. TO ENGAGE SAFETY-NET HOSPITALS EFFECTIVELY AND HELP THEM IMPLEMENT OPIOID PROGRAMS SUCH AS TOPS, MORE INFORMATION IS NEEDED ON IMPLEMENTATION BARRIERS TO TAILOR IMPLEMENTATION STRATEGIES THAT WILL BE MOST EFFECTIVE GIVEN THE LOCAL CONSTRAINTS FACED BY SAFETY-NET PROVIDERS. USING A COMBINATION OF THE LATEST PUBLICLY AVAILABLE COMMUNITY BENEFITS REPORTS AND INTERNAL REVENUE SERVICE SCHEDULE H DATA, WE WILL CATALOG HOSPITALS’ OUD SERVICES, INCLUDING TOPS, AND ASSESS THE RELATIONSHIP BETWEEN THE ADOPTION OF TOP AND VARIOUS COMMUNITY AND HOSPITAL CHARACTERISTICS, INCLUDING SAFETY-NET STATUS, AND EXAMINE TRENDS IN THE AVAILABILITY OF OUD SERVICES ACROSS TIME (AIM 1). WE WILL THEN INTERVIEW HOSPITAL DECISION MAKERS AND COMMUNITY PARTNERS AT FIVE DIVERSE SAFETY NET HOSPITALS TO BETTER UNDERSTAND BARRIERS AND FACILITATORS TO ADOPTING AND IMPLEMENTING TOPS. (AIM 2). FINALLY, WE WILL CONVENE AN EXPERT PANEL TO IDENTIFY HIGH-YIELD AND TAILORED IMPLEMENTATION STRATEGIES TO INCREASE THE AVAILABILITY OF TRANSITIONAL OPIOID PROGRAMS AND OTHER EVIDENCE-BASED OPIOID SERVICES IN UNDERSERVED COMMUNITIES (AIM 3). AS AN INTERDISCIPLINARY TEAM OF HEALTH SERVICES RESEARCHERS, WE HAVE A STRONG RECORD OF COLLABORATIVE PUBLICATION AND EXTRAMURAL FUNDING RELATED TO HOSPITAL-COMMUNITY PARTNERSHIPS AND OPIOID SERVICES. THE IMPLEMENTATION STRATEGIES DEVELOPED IN THIS STUDY WILL LEAD TO A FUTURE CLUSTER RANDOMIZED CONTROLLED TRIAL TO TEST THE EFFECTIVENESS OF TAILORING IMPLEMENTATION STRATEGIES TO SAFETY NET SETTINGS. THE LONG TERM OUTCOME IS TO INCREASE THE AVAILABILITY OF TOPS IN COMMUNITIES WHERE SIGNIFICANT DISPARITIES CURRENTLY EXIST.

DEVELOPING A TAILORED STIGMA REDUCTION INTERVENTION TO INCREASE BUPRENORPHINE PRESCRIBING AMONG RURAL PRIMARY CARE PROVIDERS IN OHIO - PROJECT SUMMARY/ABSTRACT: RURAL COUNTIES, PARTICULARLY IN APPALACHIA, ARE BATTLING FAST-GROWING OUTBREAKS OF HIV AND HAVE BEEN LABELED BY THE CDC AS VULNERABLE TO GROWING TRANSMISSION RATES DUE TO WIDESPREAD INJECTION DRUG USE. ONE OF THE MOST PROMISING MECHANISMS FOR REDUCING HIV TRANSMISSION IN THESE COMMUNITIES IS THE USE OF BUPRENORPHINE, WHICH TREATS OPIOID USE DISORDER AND ALSO REDUCES BEHAVIORS THAT INCREASE HIV RISK. DESPITE THE POTENTIAL BENEFIT OF BUPRENORPHINE, HEALTH CARE PROFESSIONALS (HCPS) IN RURAL AREAS OF THE UNITED STATES ARE MUCH LESS LIKELY TO HAVE RECEIVED THE TRAINING AND FEDERAL WAIVER NECESSARY TO PRESCRIBE THIS MEDICATION. STIGMA TOWARD PATIENTS WHO USE DRUGS IS AN ACCEPTED BARRIER TO SUBSTANCE USE TREATMENT, BUT IT ALSO IMPACTS HEALTH CARE PROFESSIONALS, ESPECIALLY RURAL PRIMARY CARE PRESCRIBERS SUCH AS PHYSICIANS, NURSE PRACTITIONERS, AND PHYSICIANS ASSISTANTS WHO ARE ON THE FRONT LINES OF THE OPIOID CRISIS. WE HAVE SHOWN IN PREVIOUS STUDIES THAT STIGMA IS A PRIMARY REASON WHY FEWER RURAL HEALTH CARE PROFESSIONALS ARE WILLING TO WORK WITH PATIENTS WITH OUD. STIGMA AND NEGATIVE ATTITUDES TOWARD PATIENTS WITH OUD, FORTUNATELY, ARE MODIFIABLE BUT REQUIRE TRAINING INTERVENTIONS THAT ARE BOTH EFFECTIVE AND FEASIBLE TO IMPLEMENT IN RURAL PRACTICE SETTINGS. PREVIOUS INTERVENTIONS HAVE BEEN USED WITH HEALTH CARE PROFESSIONALS SUCCESSFULLY TO REDUCE STIGMA, BUT THEY HAVE NOT BEEN TAILORED FOR MEDICATIONS FOR OPIOID USE, SUCH AS BUPRENORPHINE, OR FOR THE RURAL PRIMARY CARE SETTING. WE PROPOSE TO ADAPT AN EXISTING BRIEF STIGMA-REDUCTION TRAINING INTERVENTION TO THE RURAL PRIMARY CARE SETTING TO INCREASE BUPRENORPHINE PRESCRIBING AND IMPLEMENT A RANDOMIZED, PILOT STUDY TO ASSESS FEASIBILITY AND ACCEPTABILITY AMONG RURAL PRIMARY CARE PROVIDERS. OUR SPECIFIC AIMS ARE TO: 1) EXAMINE HCP KNOWLEDGE AND ATTITUDES ABOUT OUD TO UNDERSTAND THEIR RELUCTANCE TO PRESCRIBE MOUD AND MANAGE PATIENTS WITH OUD. 2) DEVELOP A PROTOTYPE NARRATIVE-BASED STIGMA REDUCTION INTERVENTION AND TAILOR IT TO THE RURAL PRIMARY CARE SETTING USING HCP FEEDBACK AND 3) ASSESS THE FEASIBILITY AND ACCEPTABILITY OF A STIGMA-REDUCTION INTERVENTION IN A PILOT STUDY IN A DIVERSE GROUP OF RURAL HCPS ACROSS 6 PRIMARY CARE CLINICS. THE PRIMARY PILOT TRIAL OUTCOMES ARE FEASIBILITY, ACCEPTABILITY, APPROPRIATENESS, AND ADOPTION, MEASURED AMONG A COHORT OF HCPS WHO DO NOT CURRENTLY PRESCRIBE BUPRENORPHINE AT FULL CAPACITY. WE WILL ALSO MEASURE ADDITIONAL STIGMA OUTCOMES SUCH AS ATTITUDES TOWARDS PATIENTS WITH OUD AND HARM REDUCTION. WE WILL USE IN-DEPTH INTERVIEWS TO FURTHER ASSESS PERCEPTIONS OF THE INTERVENTION AND FINALIZE IT FOR USE IN A FOLLOW-UP CLUSTER RANDOMIZED CONTROLLED TRIAL. THIS DEVELOPMENTAL TRIAL WILL PRODUCE A BRIEF STIGMA REDUCTION TRAINING INTERVENTION THAT IS ACCEPTABLE AND FEASIBLE TO IMPLEMENT IN RURAL PRIMARY CARE CLINICS. THE LONG-TERM GOAL IS TO ESTABLISH A BRIEF STIGMA-REDUCTION TRAINING INTERVENTION THAT IS MODIFIABLE FOR DIFFERENT PRACTICE SETTINGS AND EFFECTIVE AT INCREASING BUPRENORPHINE PRESCRIBING IN UNDERSERVED COMMUNITIES.

OHIO UNIVERSITY PROJECT TITLE: STATISTICAL NUCLEAR PHYSICS AND (ALPHA,N) REACTIONS FOR APPLICATIONS PROJECT DESCRIPTION:PROJECT OBJECTIVES ARE AN IMPROVED UNDERSTANDING OF THE MOST UNCERTAIN INPUT NUCLEAR STRUCTURE STATISTICAL QUANTITIES SUCH AS NUCLEAR LEVEL DENSITIES, GAMMA-STRENGTH FUNCTIONS, AND OPTICAL MODEL POTENTIALS USED IN REACTION CROSS SECTION CALCULATIONS AND IMPROVED NUCLEAR DATA FOR (ALPHA,N) CROSS SECTIONS AT AND BELOW COULOMB BARRIER ENERGIES, WHICH ARE IMPORTANT IN APPLICATIONS. THE GOAL IS TO CONSTRAIN AVAILABLE THEORETICAL MODELS, AND PROVIDE SPECIFIC RECOMMENDATIONS FOR PRACTICAL CALCULATIONS WHICH ARE NEEDED IN SUCH AREAS AS ASTROPHYSICS, NUCLEAR DATA EVALUATIONS, DIAGNOSTICS OF HIGH-DENSITY PLASMAS, AND NEXT GENERATION REACTOR PHYSICS. THE OTHER OBJECTIVE IS TO DEVELOP EXPERIMENTAL TECHNIQUES, COMPUTER MODELS, TRAIN THE NEXT GENERATION OF NUCLEAR SCIENTISTS, AND INVOLVE THESE SCIENTISTS IN SIMILAR ACTIVITIES AT NNSA NATIONAL LABORATORIES.

PLANTS WILL BE A CRUCIAL COMPONENT FOR ASTRONAUT HEALTH AND WELL-BEING DURING ANY LONG-DISTANCE SPACEFLIGHT OR COLONIZATION MISSION: AS A SOURCE OF FOOD FOR REPLENISHING WATER AND PURIFYING AIR AS WELL AS PHYSIOLOGICAL AND PSYCHOLOGICAL COMFORT. THE CHALLENGE IS TO UNDERSTAND HOW PLANTS RESPOND TO THE SPACEFLIGHT ENVIRONMENT TO ENABLE PLANTS TO THRIVE IN POTENTIALLY HOSTILE ENVIRONMENTS. AS TECHNOLOGIES HAVE ADVANCED FOR GLOBAL GENE EXPRESSION TRANSCRIPTOME LEVEL RESEARCH HAS BECOME AN INTEGRAL PART OF EXPERIMENTS AND PROVIDES KNOWLEDGE OF GENE EXPRESSION RESULTING FROM THE CONDITIONS OF SPACEFLIGHT. STEADY STATE TRANSCRIPT ABUNDANCE QUANTIFIED BY RNASEQ IS FREQUENTLY USED AS MEASURE OF GENE EXPRESSION WITH THE IMPLICIT ASSUMPTION THAT TRANSCRIPTIONAL CHANGES UPON A TREATMENT (SUCH AS A STRESS) ARE INDICATIVE OF THE DOWNSTREAM RESPONSE. HOWEVER CHANGES IN MRNA ABUNDANCE DO NOT NECESSARILY LEAD TO CORRESPONDING CHANGES IN PROTEIN AND TRANSCRIPT AND PROTEIN ABUNDANCE ARE NOT HIGHLY CORRELATED. THE DATA FROM SPACEFLIGHT EXPERIMENTS BRIC20 (PI WYATT) AND PLANT SIGNALING (PI PERERA) SUGGEST THAT POST-TRANSCRIPTIONAL REGULATION PLAYS AN INTEGRAL ROLE IN GENE EXPRESSION DIFFERENCES BETWEEN SPACEFLIGHT AND GROUND CONTROLS. THE DIFFERENTIAL EXPRESSION ABUNDANCE AND PHOSPHORYLATION OF TRANSLATIONAL MACHINERY IN SPACEFLIGHT LEADS TO THE OBVIOUS QUESTIONS: WHAT GENES ARE BEING POST TRANSCRIPTIONALLY REGULATED AND BY WHAT MECHANISM(S)? TO ANSWER THESE QUESTIONS PIS WYATT AND PERERA PLAN TO COMBINE EXPERTISE AND RESOURCES TO GENERATE COMPATIBLE MULTI-OMICS DATASETS AND PROVIDE A COMPREHENSIVE PICTURE OF TRANSCRIPTIONAL AND POST TRANSCRIPTIONAL REGULATION....

MOTIVATING TYPE O- BLOOD DONORS TO RETURN

ONSET OF JET ENERGY LOSS EFFECTS WITH PARTICLE-ISOLATION MEASUREMENTS AND EVENT ENGINEERING IN PROMPT PHOTON-JET AND DI-JET CORRELATIONS IN RELATIVISTIC HEAVY ION COLLISIONS WITH PHENIX AND SPHENIX

IMPROVING DARK ENERGY CONSTRAINTS USING LOW-REDSHIFT LARGE-SCALE STRUCTURES

NUCLEAR PHYSICS EXPERIMENTS WITH THE ELECTRO-WEAK PROBE -THE MEDIUM-ENERGY NUCLEAR EXPERIMENTAL PROGRAM PLANNED BY THE OHIO UNIVERSITY GROUP AIMS TO ANSWER THE QUESTIONS: HOW DOES SUBATOMIC MATTER ORGANIZE ITSELF INSIDE A PROTON OR NEUTRON? AND ARE THE FUNDAMENTAL INTERACTIONS RELATING TO THE STRUCTURE OF PROTON OR NEUTRON FULLY UNDERSTOOD? THE 2013 REPORT OF THE NATIONAL RESEARCH COUNCIL ON THE ASSESSMENT OF AND OUTLOOK FOR NUCLEAR PHYSICS RECOGNIZES BOTH OF THOSE QUESTIONS AS CENTRAL TO TODAY?S NUCLEAR PHYSICS. SPECIFICALLY, THE PI?S RESEARCH FOCUSES ON STUDYING THE INTERNAL STRUCTURE OF PROTONS AND NEUTRONS. THE STRONG FORCE, ONE OF NATURE?S FOUR FUNDAMENTAL FORCES, GOVERNS THIS INTERNAL STRUCTURE. THE PIS WILL ALSO STUDY THE LIMITS OF OUR UNDERSTANDING OF NATURE?S FUNDAMENTAL FORCES BY LOOKING FOR PHYSICS BEYOND THE STANDARD MODEL OF PARTICLE PHYSICS. THEY WILL WORK WITH AN ELECTRON BEAM COLLIDING WITH A NUCLEAR TARGET AT THE THOMAS JEFFERSON NATIONAL ACCELERATOR FACILITY (JLAB). PIS ROCHE AND KING, THREE GRADUATE STUDENTS, AND THREE UNDERGRADUATE STUDENTS WILL PERFORM THE RESEARCH SUPPORTED BY THIS AWARD. THE BROADER IMPACTS OF THE PROGRAM ARE MULTIFOLD, INCLUDING TRAINING THE NEXT GENERATION OF SCIENTISTS, RAISING THE PROFILE OF MINORITY SCIENTISTS (ESPECIALLY MENTORING WOMEN IN STEM), AND ENGAGING THE PUBLIC THROUGH STEM EDUCATION FOR HIGH SCHOOL STUDENTS. THE OHIO GROUP WILL WORK ON TWO EXPERIMENTS DEDICATED TO THE STUDY OF THE INTERNAL STRUCTURE OF THE NUCLEON USING THE GENERALIZED PARTON DISTRIBUTION FRAMEWORK. EXPERIMENT E12-19-006 MEASURES L-T SEPARATION IN CHARGED PION PRODUCTION: THE GROUP WILL ANALYZE ITS DATA ACQUIRED IN 2021 AND 2022. EXPERIMENT E12-13-010 WILL MEASURE THE ELECTROPRODUCTION OF A PHOTON USING THE NEUTRAL PARTICLE SPECTROMETER; ROCHE IS A CO-SPOKESPERSON OF THIS EXPERIMENT. ITS DATA-TAKING WILL START IN 2023. THE GROUP WILL TAKE DATA AND PERFORM THEIR EARLY ANALYSIS DURING THIS AWARD. IN ADDITION, KING WILL COORDINATE THE ANALYSIS SOFTWARE DEVELOPMENT FOR THE NEXT GENERATION OF PARITY VIOLATION EXPERIMENTS KNOWN AS MOLLER. MEMBERS OF THE GROUP WILL ALSO PARTICIPATE IN THE HALL A SBS EXPERIMENTAL PROGRAM. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

INTRACORTICAL MECHANISMS OF MUSCLE WEAKNESS

CHEMICAL AND BIOMOLECULAR ENGINEERING GAANN PROGRAM

RURAL HEALTH CARE SERVICES OUTREACH GRANT PROGRAM

STUDIES IN LOW ENERGY NUCLEAR SCIENCE

ACE: APPALACHIAN COHORT FOR ENGINEERING

MRI: TRACK 1 ACQUISITION OF A UNIVERSITY-WIDE COMPUTATIONAL CLUSTER -THIS PROJECT IS TO PROCURE A COMPUTER CLUSTER FOR OHIO UNIVERSITY (OHIO). RESEARCHERS AT OHIO WILL LEVERAGE THE CLUSTER TO SCREEN MILLIONS OF CHEMICAL COMPOUNDS FOR THEIR EFFECTIVENESS AGAINST SOME DISEASE TO SHORTLIST A HANDFUL OF POTENTIAL THERAPEUTIC COMPOUNDS THAT CAN BE TESTED FURTHER IN A LABORATORY. OHIO RESEARCHERS PLAN TO USE THE CLUSTER FOR NUMEROUS OTHER APPLICATIONS, SUCH AS IMPROVING ELECTRIC CAR BATTERIES, ENHANCING NAVIGATIONAL AIDS OF AIRPLANES, AUTOMATING SCREENING OF MEDICAL IMAGES FOR TUMORS, MITIGATING RUSTING IN OIL AND GAS PIPELINES, GENERATING ENVIRONMENTALLY FRIENDLY CONSTRUCTION MATERIALS FROM COAL, AND IDENTIFYING ABNORMAL GENES IN THE HUMAN BODY. ADDITIONALLY, THE CLUSTER WILL BE UTILIZED BY EDUCATORS ACROSS DISCIPLINES, ALLOWING STUDENTS TO DEVELOP STRONG DATA ANALYSIS SKILLS NECESSARY IN FIELDS SPANNING SCIENCES, ENGINEERING, AND ECONOMICS. OHIO IS THE LEADING INSTITUTION FOR INTEL APPALACHIAN SEMICONDUCTOR EDUCATION AND TECHNICAL (ASCENT) ECOSYSTEM THAT AIMS TO TRAIN THE WORKFORCE FOR THE SEMICONDUCTOR INDUSTRY. THE ASCENT PROGRAM WILL RELY ON THE COMPUTER CLUSTER TO TRAIN THE STUDENTS IN DATA ANALYTICS AND MACHINE LEARNING. OHIO CURRENTLY LACKS ITS OWN COMPUTER CLUSTER, SIGNIFICANTLY IMPEDING RESEARCH AND TEACHING RELIANT ON SUCH INFRASTRUCTURE. AN IN-HOUSE COMPUTER CLUSTER WILL ENABLE A DIVERSE VARIETY OF RESEARCH THAT REQUIRE QUANTUM CALCULATIONS, MOLECULAR SIMULATIONS, MACHINE LEARNING, BIG DATA ANALYSIS, NUMERICAL OPTIMIZATION, IMAGE ANALYSIS, PATTERN DETECTION, WEATHER SIMULATIONS, AND FINITE ELEMENT ANALYSIS. THE RESEARCH ENABLED WILL RESULT IN SIGNIFICANT TECHNOLOGICAL MILESTONES, INCLUDING BUT NOT LIMITED TO THE DESIGN OF NEW CORROSION INHIBITORS, DRUG DISCOVERY, TRANSFORMING COAL TO A GREEN SOURCE OF CONSTRUCTION MATERIALS, CREATING A CLEAN SOURCE OF GRAPHITE FOR ELECTRIC CAR BATTERIES, AUTOMATION OF MEDICAL IMAGE ANALYSIS TO DETECT TUMORS, GENETICS, AND DEVELOPING NOVEL TECHNOLOGIES FOR AIRPLANE NAVIGATION. THE CLUSTER WILL BE AN IMPORTANT TEACHING TOOL AS WELL. WITH THE ADVENT OF BIG DATA AND MACHINE LEARNING AS WELL AS RAPID DEVELOPMENTS IN VARIOUS COMPUTATIONAL FIELDS, IT IS ESSENTIAL THAT UNDERGRADUATE AND GRADUATE STUDENTS ARE TRAINED IN THESE AREAS SO THAT THEIR SKILLS MEET THE INDUSTRY NEEDS. OHIO IS THE LEAD INSTITUTION FOR ASCENT, WHICH IS A WORKFORCE DEVELOPMENT AND TRAINING PROGRAM TO CULTIVATE SKILLED PROFESSIONALS FOR OHIO?S SEMICONDUCTOR INDUSTRY. AN IN-HOUSE CLUSTER WILL BE PIVOTAL FOR IMPARTING TRAINING IN DATABASE MANAGEMENT SYSTEMS, MACHINE LEARNING, ALGORITHMS, OPTIMIZATION, AND OTHER SEMICONDUCTOR INDUSTRY-SPECIFIC NEEDS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

MECHANISMS OF MUSCLE ADAPTATIONS IN AGING AND EXERCISE - PROJECT SUMMARY/ABSTRACT THE UNITED STATES IS EXPERIENCING A SIGNIFICANT DEMOGRAPHIC SHIFT, WITH THE NUMBER OF OLDER ADULTS PROJECTED TO INCREASE BY 18 MILLION IN THE NEXT DECADE, REACHING 90 MILLION BY 2050. THIS SURGE WILL TRANSFORM HEALTHCARE NEEDS AND PLACE CONSIDERABLE STRAIN ON SOCIAL AND ECONOMIC SYSTEMS, PARTICULARLY DUE TO AGE-RELATED HEALTH CHALLENGES SUCH AS SARCOPENIA. SARCOPENIA IS ASSOCIATED WITH INCREASED RISKS OF DISABILITY, FALLS, HOSPITALIZATION, NURSING HOME ADMISSIONS, IMPAIRED MOBILITY, AND EARLY MORTALITY. DESPITE THESE SERIOUS IMPLICATIONS, THERE ARE NO FDA- APPROVED DRUGS FOR SARCOPENIA, AND NOT ALL AGING INDIVIDUALS CAN EXERCISE EFFECTIVELY TO COUNTER IT. OUR RECENT DATA SUGGEST THAT THE RNA-BINDING PROTEIN HUMAN ANTIGEN R (HUR OR ELAV-LIKE PROTEIN 1) MAY SERVE AS A NOVEL, AGE-DEPENDENT MEDIATOR OF EXERCISE-INDUCED ADAPTATIONS AND REGULATE THE CONTENT OF MYOSIN BINDING PROTEIN H (MYBP-H). WE FOUND THAT HUR ACTIVITY VARIES WITH AGE AND PARALLELS POSITIVE MUSCLE ADAPTATIONS FOLLOWING ECCENTRIC EXERCISE TRAINING IN MICE. ADDITIONALLY, HUR-DEFICIENT MICE EXHIBITED SIGNIFICANT PROTECTION FROM STRENGTH DEFICITS TYPICALLY OBSERVED AFTER ECCENTRIC CONTRACTION-INDUCED INJURY, WITHOUT COMPROMISING OTHER FUNCTIONAL PARAMETERS. PROTEOMIC ANALYSIS REVEALED THAT SEVERAL PROTEINS REGULATED BY TRAINING WERE ALSO REGULATED BY HUR DELETION, WITH MYBP-H BEING THE MOST SIGNIFICANTLY UPREGULATED. FURTHERMORE, A NOVEL SMALL MOLECULE INHIBITOR OF HUR (KH-3) PROTECTED MUSCLE FROM STRENGTH LOSS, SIMILAR TO TRAINING OR GENETIC DELETION OF HUR. THIS PROPOSAL AIMS TO DEMONSTRATE THAT AGE-DEPENDENT REGULATION OF HUR AND MYBP-H DICTATES HOW SKELETAL MUSCLE RESPONDS TO ECCENTRIC EXERCISE TRAINING. WE HYPOTHESIZE THAT HUR-DEPENDENT EXPRESSION OF MYBP-H IS A PRIMARY MOLECULAR MECHANISM CONTRIBUTING TO EXERCISE-INDUCED ADAPTATIONS IN SKELETAL MUSCLE. THIS STUDY WILL SYSTEMATICALLY TEST THIS HYPOTHESIS AND BRIDGE BASIC BIOLOGY TO POTENTIAL THERAPEUTIC APPLICATIONS. AIM 1: ESTABLISH IF HUR MEDIATES SKELETAL MUSCLE ADAPTATIONS TO EXERCISE. WE WILL USE LOSS-OF-FUNCTION AND GAIN-OF-FUNCTION MOUSE MODELS, IN ADDITION TO A PHARMACOLOGICAL INHIBITOR OF HUR RNA-BINDING. AIM 2: IDENTIFY THE MECHANISMS BY WHICH HUR ACTIVITY REGULATES SKELETAL MUSCLE ADAPTATIONS TO EXERCISE AND MYBP-H EXPRESSION. WE WILL INVESTIGATE HOW CHANGES IN HUR ACTIVITY INFLUENCE GENE EXPRESSION USING HIGH-THROUGHPUT TECHNIQUES AND SPECIFIC IN VITRO METHODOLOGIES. AIM 3: DETERMINE IF MYBP-H CONTENT PROTECTS SKELETAL MUSCLE FROM EXERCISE-INDUCED INJURY. WE WILL MANIPULATE MYBP-H EXPRESSION USING GENETIC DEPLETION AND OVEREXPRESSION IN MICE. WE ANTICIPATE THAT INCREASING MYBP-H CONTENT, FACILITATED BY INHIBITING HUR ACTIVITY, WILL ENHANCE THE MUSCLE'S ABILITY TO RESIST AND ADAPT TO EXERCISE-INDUCED INJURY. THIS WORK IS TIMELY AND INNOVATIVE, FILLING A CRITICAL GAP IN OUR UNDERSTANDING OF HOW SKELETAL MUSCLE ADAPTS TO EXERCISE TRAINING, PARTICULARLY IN AN AGE-DEPENDENT MANNER. BY COMBINING GENETIC AND PHARMACOLOGICAL MODELS WITH FOCUSED ANALYSIS OF CELLULAR AND MOLECULAR MECHANISMS, WE AIM TO IDENTIFY NEW STRATEGIES TO ENHANCE THE RESILIENCY AND HEALTH SPAN OF AGING MUSCLE.

CAREER: MECHANOCHEMISTRY - BREAKING SOLUTION-PHASE BARRIERS TO ACCESS CHALLENGING METAL-ORGANIC FRAMEWORKS -PART 1: NON-TECHNICAL SUMMARY WITH SUPPORT FROM THE SOLID STATE AND MATERIALS CHEMISTRY PROGRAM, THIS NSF CAREER PROJECT EXPLORES A NEW WAY TO CREATE ADVANCED POROUS MATERIALS CALLED METAL-ORGANIC FRAMEWORKS (MOFS). THESE MATERIALS ARE BUILT FROM METAL IONS AND ORGANIC MOLECULES AND CAN STORE GAS, CLEAN WATER, CAPTURE CARBON DIOXIDE, AND SUPPORT CHEMICAL REACTIONS USED IN ENERGY TECHNOLOGIES. TRADITIONALLY, MOFS ARE MADE IN HOT LIQUID SOLUTIONS THAT REQUIRE HIGH TEMPERATURES AND LARGE AMOUNTS OF TOXIC SOLVENTS. THESE HARSH CONDITIONS PREVENT SCIENTISTS FROM USING MANY DELICATE BUILDING BLOCKS THAT COULD GIVE THE MATERIALS IMPORTANT NEW FUNCTIONS. THIS PROJECT USES A DIFFERENT STRATEGY CALLED MECHANOCHEMISTRY, IN WHICH CHEMICAL REACTIONS ARE DRIVEN BY MECHANICAL FORCE, SUCH AS GRINDING OR MILLING, INSTEAD OF HEAT AND SOLVENTS. WORKING WITHOUT SOLVENT, ALSO KNOWN AS WORKING IN THE SOLID STATE, ALLOWS REACTIONS TO TAKE PLACE QUICKLY AT ROOM TEMPERATURE AND OPENS THE DOOR TO NEW STRUCTURES THAT CANNOT BE FORMED USING TRADITIONAL LIQUID-BASED METHODS. THE RESEARCH AIMS TO CREATE NEW FAMILIES OF MOFS THAT INCLUDE SENSITIVE COMPONENTS, SHOW UNUSUAL INTERNAL STRUCTURES, OR EXHIBIT PREVIOUSLY INACCESSIBLE PROPERTIES. THE PROJECT PROVIDES PAID RESEARCH OPPORTUNITIES FOR UNDERGRADUATE STUDENTS, CREATES A ONE-CREDIT COURSE FOCUSED ON SUSTAINABLE CHEMISTRY AND SCIENTIFIC CAREER DEVELOPMENT, AND DELIVERS HANDS-ON WORKSHOPS FOR K?12 STUDENTS ACROSS APPALACHIAN OHIO. ALL ACTIVITIES ARE DESIGNED TO STRENGTHEN STEM WORKFORCE DEVELOPMENT. PART 2: TECHNICAL SUMMARY WITH SUPPORT FROM THE SOLID STATE AND MATERIALS CHEMISTRY PROGRAM, THIS NSF CAREER PROJECT ESTABLISHES MECHANOCHEMISTRY AS A SYNTHETIC PLATFORM CAPABLE OF PRODUCING METAL-ORGANIC FRAMEWORKS (MOFS) THAT ARE INACCESSIBLE THROUGH SOLVOTHERMAL CHEMISTRY. THE RESEARCH LEVERAGES KEY FEATURES OF SOLID-STATE REACTIONS, INCLUDING RESTRICTED MOLECULAR MOBILITY, SOLVENT-FREE CONDITIONS, AND RAPID REACTION KINETICS, TO EXPAND THE STRUCTURAL AND FUNCTIONAL LANDSCAPE OF MOFS. THREE RESEARCH DIRECTIONS DEFINE THE CORE OF THE PROJECT. FIRST, AMBIENT MECHANOCHEMICAL CONDITIONS WILL BE USED TO INCORPORATE ORGANIC AND INORGANIC MOTIFS THAT DEGRADE UNDER CONVENTIONAL SOLVOTHERMAL CONDITIONS, ENABLING ACCESS TO FRAGILE OR REACTIVE LINKERS AND NODES. SECOND, THE PROJECT WILL EXPLOIT SOLID-STATE DYNAMICS TO FAVOR KINETICALLY PREFERRED PRODUCTS, THEREBY GENERATING NEW CONNECTIVITY REGIMES, CLUSTERED DEFECT ARCHITECTURES, NON-EQUILIBRIUM TOPOLOGIES, AND HIERARCHICAL POROSITY. THIRD, NEUTRON SCATTERING METHODS WILL BE APPLIED TO PROBE ATOMISTIC STEPS OF MECHANOCHEMICAL MOF FORMATION, PROVIDING INSIGHTS INTO SHORT-RANGE ORDER, AMORPHOUS INTERMEDIATES, AND BOND REARRANGEMENTS DURING MILLING. TOGETHER, THESE EFFORTS WILL ESTABLISH MECHANOCHEMISTRY AS A PRECISION-CONTROLLED SYNTHETIC REGIME AND REVEAL FUNDAMENTAL PRINCIPLES THAT GOVERN SOLID-STATE REACTIVITY IN FRAMEWORK MATERIALS. THE PROJECT PROVIDES PAID RESEARCH OPPORTUNITIES FOR UNDERGRADUATE STUDENTS, CREATES A ONE-CREDIT COURSE FOCUSED ON SUSTAINABLE CHEMISTRY AND SCIENTIFIC CAREER DEVELOPMENT, AND DELIVERS HANDS-ON WORKSHOPS FOR K?12 STUDENTS ACROSS APPALACHIAN OHIO. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

CONSTRAINING NEUTRON STAR STRUCTURE WITH INDIRECT NUCLEAR REACTION STUDIES

INVESTIGATE BENEFITS OF UTILIZING GPS DA INTEGRATED AVIONICS TECHNOLOGY DEVELOPME

NATIONAL RESOURCE CENTERS

CAREER: DEVELOPMENT OF MICROSECOND TIME-RESOLVED MASS SPECTROMETRY FOR THE STUDY OF BIOCHEMICAL REACTION MECHANISMS AND KINETICS

LINKING LOCAL KNOWLEDGE AND LOCAL INSTITUTIONS FOR THE STUDY OF ADAPTIVE CAPACITY TO CLIMATE CHANGE: PARTICIPATORY GIS IN NORTHERN TANZANIA

OHIO UNIVERSITY SURVIVOR ADVOCACY PROGRAM

MECHANISMS OF ACTIVITY-DEPENDENT TAU RELEASE: THE ROLE OF TAU INTERACTING PROTEINS - PROJECT SUMMARY A KEY PATHOLOGICAL HALLMARK OF ALZHEIMER’S DISEASE (AD) IS THE FORMATION OF INTRACELLULAR NEUROFIBRILLARY TANGLES (NFTS), COMPOSED OF HYPERPHOSPHORYLATED AND AGGREGATED TAU. THE TEMPORAL AND SPATIAL PROGRESSION OF NFTS IN THE HUMAN BRAIN CLOSELY CORRELATES WITH AD SEVERITY. IN RECENT YEARS, AN EMERGING PRION-LIKE MODEL OF TAU PROPAGATION HAS GAINED ATTENTION, SUGGESTING THAT TAU SPREADS TRANS-SYNAPTICALLY BETWEEN CONNECTED NEURONS, CONTRIBUTING TO DISEASE PROGRESSION. HOWEVER, THE PRECISE MECHANISMS GOVERNING THIS SPREAD REMAIN POORLY UNDERSTOOD. INCREASING EVIDENCE LINKS NEURONAL HYPEREXCITABILITY TO EARLY AD PATHOGENESIS. ALTHOUGH TAU IS PRIMARILY AN INTRACELLULAR PROTEIN, IT CAN BE RELEASED INTO THE EXTRACELLULAR SPACE UPON NEURONAL ACTIVATION. UNDERSTANDING THE MOLECULAR MECHANISMS UNDERLYING ACTIVITY-DEPENDENT TAU RELEASE IS THEREFORE OF SIGNIFICANT INTEREST. THIS STUDY AIMS TO ELUCIDATE THE MECHANISMS OF TAU RELEASE DRIVEN BY NEURONAL HYPEREXCITABILITY, USING A DROSOPHILA MODEL AND HUMAN NEURAL CELL LINES. AIM 1 IS TO INVESTIGATE THE MECHANISM OF ACTIVITY-DEPENDENT TAU RELEASE FROM NEURONS AND SYNAPSES. OUR PRELIMINARY DATA SHOW THAT HUMAN TAU (HTAU) RELEASE FROM DROSOPHILA NEUROMUSCULAR JUNCTIONS (NMJS) IS SYNAPTIC TRANSMISSION-DEPENDENT. GIVEN PREVIOUS EVIDENCE OF TRANS-SYNAPTIC TAU PROPAGATION, WE HYPOTHESIZE THAT SYNAPTIC VESICLE PROTEINS (E.G., SYNAPTOGYRIN, SV2A, ETC.) REGULATE TAU RELEASE. THIS AIM WILL FOCUS ON PRE-SELECTED SYNAPTIC VESICLE PROTEINS WITH KNOWN TAU INTERACTIONS. AIM 2 IS TO IDENTIFY AND CHARACTERIZE NOVEL TAU- INTERACTING PROTEINS INVOLVED IN ACTIVITY-DEPENDENT TAU RELEASE USING AN UNBIASED PROTEIN INTERACTOME APPROACH. UNLIKE AIM 1, WHICH TESTS PRE-SELECTED CANDIDATES, AIM 2 WILL EXAMINE NEWLY IDENTIFIED PROTEINS RESULTING FROM PROTEOMIC SCREENING TO UNCOVER ADDITIONAL REGULATORS OF TAU RELEASE. AIM 3 IS TO VALIDATE AND EXTEND FINDINGS FROM AIMS 1 AND 2 IN A HUMAN NEURAL CELL LINE THAT ENDOGENOUSLY EXPRESSES TAU, ENSURING TRANSLATIONAL RELEVANCE. SUCCESSFUL COMPLETION OF THIS PROJECT WILL PROVIDE CRITICAL INSIGHTS INTO THE MECHANISMS OF TAU RELEASE AND PROPAGATION, OFFERING NOVEL THERAPEUTIC TARGETS FOR AD AND OTHER TAUOPATHIES.

ECA/A/E/USS ACADEMIC EXCHANGE PROGRAMS: STUDY OF THE US PROGRAMS PROJECT: GLOBAL

DISCOVERY OF THE NEURAL DRIVERS UNDERLYING INJURY-RISK BIOMECHANICS - 1 PROJECT SUMMARY/ABSTRACT 2 ANTERIOR CRUCIATE LIGAMENT (ACL) INJURY IS A DEBILITATING CONDITION THAT RESULTS IN CONSISTENT KNEE DEGENERATION 3 AND REDUCED PHYSICAL ACTIVITY CAPACITY, WITH CUMULATIVE HEALTH CARE COSTS EXCEEDING SEVERAL BILLION DOLLARS PER 4 ANNUM. THE MOST COMMON MECHANISM OF ACL INJURY IS WITHOUT PLAYER TO PLAYER CONTACT (TERMED NON-CONTACT) 5 AND SECONDARY TO MOTOR COORDINATION ERRORS THAT RESULT IN INJURIOUS KNEE JOINT LOADING. AS SUCH, THE CURRENT 6 STANDARD FOR INJURY PREVENTION IS NEUROMUSCULAR OR MOVEMENT TRAINING TO CORRECT RESULTANT SPECIFIC INJURY-RISK 7 MECHANICS IN CONTROLLED SETTINGS. HOWEVER, INJURY REDUCTION STRATEGIES HAVE NOT ACHIEVED SUFFICIENT EFFICACY DUE 8 TO INADEQUATE TARGETING OF CENTRAL NERVOUS SYSTEM CONTRIBUTIONS TO THE MOTOR ERRORS THAT MAY UNDERLIE AND 9 PROPAGATE INJURY-RISK IN ECOLOGICALLY VALID SETTINGS. OUR PUBLISHED PROSPECTIVE LONGITUDINAL DATA, AND PRELIMINARY 10 ECOLOGICALLY VALID SPORT-SPECIFIC VIRTUAL REALITY DATA, INDICATES THAT SENSORIMOTOR BRAIN ACTIVITY UNDERLY ACL INJURY- 11 RISK. THUS, THE OBJECTIVE OF THIS APPLICATION IS TO DETERMINE THE BRAIN ACTIVITY ASSOCIATED WITH INJURY-RISK MOTOR 12 CONTROL IN STANDARD AND ECOLOGICALLY VALID SPORT-SPECIFIC VIRTUAL REALITY SETTINGS. OUR PRELIMINARY DATA INFORM 13 OUR CENTRAL HYPOTHESIS THAT THOSE WITH INJURY-RISK MOVEMENT PATTERNS RELY ON A VISUAL AND COGNITIVE-MOTOR NEURAL 14 ACTIVATION STRATEGY, THAT IS FURTHER ACCENTUATED IN ECOLOGICALLY VALID SPORT VIRTUAL REALITY. THE PROPOSED RESEARCH IS 15 INNOVATIVE BECAUSE IT REPRESENTS A NEW AND SUBSTANTIAL DEPARTURE FROM PRIOR WORK THAT FOCUSED PRIMARILY ON 16 BIOMECHANICAL OUTCOMES, TO NOW DETERMINE THE NEURAL ACTIVITY PROPAGATING INJURY-RISK KNEE MOTOR CONTROL. A KEY 17 BREAKTHROUGH OF THIS PROPOSAL IS THE BIOMECHANICAL INSTRUMENTATION OF KNEE MOTOR CONTROL ERROR IN REAL-TIME DURING 18 NEUROIMAGING. THE EXPECTED OUTCOMES FROM THIS OBSERVATIONAL TRIAL WILL BE THE IDENTIFICATION OF THE UNDERLYING 19 KNEE MOTOR CONTROL NEURAL ACTIVITY RELATED TO ACL INJURY-RISK BIOMECHANICS. SUCCESSFUL COMPLETION OF THE PROPOSED 20 AIMS WILL STRATEGICALLY POSITION US TO DEVELOP A COMPETITIVE R01 CLINICAL TRIAL APPLICATION THAT ASSESSES NOVEL 21 NEUROMUSCULAR TRAINING TO TARGET THE NEURAL PROCESSES IDENTIFIED BY THIS PROPOSAL. SPECIFICALLY, GUIDED BY THE 22 NEURAL ACTIVATION STRATEGIES IDENTIFIED HEREIN, WE WILL REFINE PREVENTION PROGRAMS USING NOVEL BIOFEEDBACK 23 METHODS, CLINICAL TECHNOLOGIES, AND MOTOR LEARNING PRINCIPLES TO FACILITATE ADAPTIVE BRAIN FUNCTION THAT REDUCES 24 INJURY INCIDENCE. THUS, AVOIDING THE LIFELONG PAIN, OSTEOARTHRITIS, AND PHYSICAL ACTIVITY LIMITATIONS, DIRECTLY ALIGNING 25 WITH NIH INITIATIVES TO REDUCE INJURY AND PHYSICAL INACTIVITY IN YOUTH AND ADULTS, WHICH IS THE FOURTH LEADING CAUSE 26 OF GLOBAL MORTALITY. 27 28

THE STEWARDSHIP SCIENCE ACADEMIC ALLIANCES (SSAA) PROGRAM WAS ESTABLISHED IN 2002 TO SUPPORT STATE-OF-THE-ART RESEARCH AT U.S. ACADEMIC INSTITUTIONS IN AREAS OF FUNDAMENTAL PHYSICAL SCIENCE AND TECHNOLOGY OF RELEVANCE TO THE SSP MISSION. THE SSAA PROGRAM PROVIDES THE RESEARCH EXPERIENCE NECESSARY TO MAINTAIN A CADRE OF TRAINED SCIENTISTS AND ENGINEERS AT U.S. UNIVERSITIES TO MEET THE NATION’S CURRENT AND FUTURE SSP NEEDS, WITH A FOCUS ON THOSE AREAS NOT SUPPORTED BY OTHER FEDERAL AGENCIES. IT SUPPORTS THE DOE/NNSA’S PRIORITIES BOTH TO ADDRESS THE WORKFORCE SPECIFIC NEEDS IN SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS AND TO SUPPORT THE NEXT GENERATION OF PROFESSIONALS WHO WILL MEET THOSE NEEDS

STUDIES IN LOW ENERGY NUCLEAR SCIENCE

OHIO UNIVERSITY STATISTICAL NUCLEAR PHYSICS AND (A,N) REACTIONS FOR APPLICATIONS

BMAT: SELF-ASSEMBLY OF EXTENSIN GLYCOPROTEINS FOR DESIGNING NOVEL PLANT-BASED BIOPOLYMERS -NON-TECHNICAL SUMMARY ALL LIVING CREATURES ON EARTH ARE MADE OF CELLS. EACH CELL IS ENCLOSED BY AN EXTRACELLULAR MATRIX. YOU CAN THINK OF AN EXTRACELLULAR MATRIX AS A HOUSING THAT PROTECTS AND CONTAINS A CELL?S CONTENTS. IN PLANTS, THAT HOUSING IS PARTICULARLY STRONG AND RIGID AND IS COMPOSED OF A WIDE VARIETY OF BIOPOLYMERS. ONE SUCH POLYMER IS KNOWN AS EXTENSIN. AS ITS NAME IMPLIES, EXTENSIN PLAYS AN IMPORTANT ROLE IN CONTROLLING PLANT GROWTH AND EXTENSION, AND IT DOES SO BY FORMING A POLYMERIC MOLECULAR SCAFFOLD OR FRAME. THIS WORK AIMS TO UNDERSTAND WHAT GOVERNS SCAFFOLD FORMATION AT THE MOLECULAR LEVEL AND HOW WE CAN USE THIS KNOWLEDGE TO DESIGN NEW BIOPOLYMERS THAT MIMIC OR IMITATE THE PROPERTIES OF NATURAL EXTENSINS. IN THE FACE OF GLOBAL CLIMATE CHANGE, OUR RELIANCE ON FOSSIL FUELS MUST BE REDUCED, NOT ONLY FOR USE AS TRANSPORTATION FUELS, BUT ALSO AS CHEMICAL/POLYMER FEEDSTOCKS. POTENTIAL INDUSTRIAL APPLICATIONS OF THIS RESEARCH ARE NUMEROUS AND INCLUDE THE CREATION OF BIODEGRADABLE PLASTICS, MOLECULAR ELECTRONICS, FOOD ENHANCEMENT, COSMETICS ADDITIVES, ETC. THIS RESEARCH WILL ALSO PROVIDE TRAINING OPPORTUNITIES FOR UNDERGRADUATE AND GRADUATE STUDENTS IN BIOPHYSICAL CHEMISTRY AND BIOCHEMISTRY. NEW UNDERGRADUATE COURSE MATERIALS FOR PHYSICAL CHEMISTRY AND BIOCHEMISTRY WILL BE DEVELOPED, AND VARIOUS OUTREACH AND SCIENTIFIC LITERACY PROJECTS FOR PRIMARY/SECONDARY SCHOOL AGED CHILDREN AND ADULTS ARE PLANNED. TECHNICAL SUMMARY EXTENSINS (EXTS) ARE NETWORK-FORMING HYDROXYPROLINE-RICH GLYCOPROTEINS FOUND NATURALLY IN PLANT CELL WALLS. MONOMERIC EXTS SELF-ASSEMBLE TO FORM INSOLUBLE POLYMERIC CELL WALL SCAFFOLDS. VERY LITTLE IS KNOWN ABOUT WHAT GOVERNS EXT SELF-ASSEMBLY AT THE MOLECULAR LEVEL. ATOMIC FORCE MICROSCOPY (AFM) HAS BEEN PREVIOUSLY USED TO EXPLORE THE BEHAVIOR OF EXT SELF-ASSEMBLY. THESE STUDIES SHOWED THAT EXT MONOMERS SPONTANEOUSLY SELF-ASSEMBLE INTO INTRICATE DENDRITIC SCAFFOLDS. FURTHERMORE, DIFFERENT EXT TYPES DISPLAYED DIFFERENT SELF-ASSEMBLY BEHAVIORS, WHEREBY SOME EXTS FAVORED MORE XY-PLANE GROWTH (TERMED ?BRANCHING?), WHILE OTHERS DISPLAYED Z-PLANE GROWTH (TERMED ?STACKING?). THESE CHANGES WERE ATTRIBUTED TO DIFFERENCES IN THE REPETITIVE, MODULAR, AND AMPHIPHILIC NATURE EXHIBITED BY DIFFERENT EXTS. TO BETTER UNDERSTAND THE MOLECULAR DRIVERS OF EXT SELF-ASSEMBLY, THREE OBJECTIVES ARE PROPOSED. FIRST, WILL BE FURTHER CHARACTERIZE THE SELF-ASSEMBLY OF NATIVE EXT GLYCOPROTEINS BY AFM TO STUDY THEIR KINETICS, PORE SIZES, AND RELATIVE GROWTH IN THE X-, Y-, AND Z-PLANES. SYNTHETIC BIOLOGY WILL THEN BE USED TO CREATE BIOMIMETIC EXTS THAT VARY IN AMPHIPHILICITY, MODULARITY, AND REPETITIVENESS AND TEST FOR THEIR SELF-ASSEMBLY BEHAVIOR USING AFM. LASTLY, THE BIOCHEMICAL AND BIOPHYSICAL PROPERTIES OF SYNTHETIC SELF-ASSEMBLED EXTS WILL BE CHARACTERIZED AND COMPARED WITH A FOCUS ON MONOMER ADHESION STRENGTH AND POLYMER FLEXIBILITY. ELUCIDATING THE MOLECULAR RULES THAT GOVERN EXT SELF-ASSEMBLY IS EXPECTED TO FACILITATE THE RATIONAL DESIGN OF SYNTHETIC, PLANT-BASED BIOMIMETIC BIOPOLYMERS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

BEHAVIORAL HEALTH WORKFORCE EDUCATION AND TRAINING FOR PROFESSIONALS AND PARAPROFESSIONALS

STUDY OF THE ELECTROWEAK STRUCTURE OF THE NUCLEON

SHF: MEDIUM: COLLABORATIVE RESEARCH: PHOTONIC NEURAL NETWORK ACCELERATOR FOR ENERGY-EFFICIENT HETEROGENEOUS MULTICORE ARCHITECTURES

SEARCH FOR NEW MESON AND BARYON RESONANCES

CAREER: UNDERSTANDING THE INTERACTIONS BETWEEN SURFACTANTS AND METALLIC NANOPARTICLES USING MOLECULAR SIMULATION

THIS PROJECT CONSISTS OF THREE COMPONENTS. THE FIRST IS MEASUREMENTS OF 9BE(N, 2N) AND 56FE(N,N’) AT OHIO UNIVERSITY’S EDWARDS ACCELERATOR LABORATORY. THE SECOND IS A MEASUREMENT OF THE 35CL(N,P) CROSS SECTION AT OHIO UNIVERSITY. THE THIRD IS THE DEVELOPMENT OF A HYBRID R-MATRIX MODEL FOR FITTING EXPERIMENTAL DATA. THE MAJOR OHIO UNIVERSITY PARTICIPANTS ARE CARL BRUNE (PI) AND THOMAS MASSEY. MUCH OF THE WORK WILL BE DONE IN COLLABORATION WITH OTHER SCIENTISTS: THE (N,2N) AND (N,N’) MEASUREMENTS WILL BE DONE IN COLLABORATION WITH RICHARD HUGHES (LLNL) AND THE HYBRID R-MATRIX MODEL WILL BE DONE IN COLLABORATION WITH GERRY HALE (LANL), MARK PARIS (LANL), AND JAMES DEBOER (NOTRE DAME). THE BENEFITS OF THIS PROJECT WILL BE MORE ACCURATE EVALUATIONS OF NUCLEAR CROSS SECTIONS AND A BETTER UNDERSTANDING OF THE SYSTEMATIC ERRORS IN THESE CROSS SECTIONS. THE PROJECT WILL PROVIDE PH.D. PROJECTS FOR THREE GRADUATE STUDENTS. THE TRAINING AND MENTORING OF STUDENTS IS A KEY COMPONENT OF THE PROPOSED WORK.

MACROEVOLUTIONARY CONSEQUENCES OF STAMINODE EVOLUTION IN INTEGRATED FLORAL SYSTEMS OF MENTZELIA SECTION BARTONIA (LOASACEAE)

SHF: MEDIUM: COLLABORATIVE RESEARCH: MACHINE LEARNING ENABLED NETWORK-ON-CHIP ARCHITECTURES FOR OPTIMIZED ENERGY, PERFORMANCE AND RELIABILITY

CAREER: DESIGN OF RECONFIGURABLE POWER AND AREA-EFFICIENT NANOPHOTONIC ARCHITECTURES FOR FUTURE MULTI-CORES

MATERIALS WORLD NETWORK - COLLABORATIVE RESEARCH: SYMMETRY, LOCAL-ENVIRONMENT AND TIME-DEPENDENT EFFECTS IN NANOSCALE SYSTEMS: A SYNERGISTIC APPROACH

A SEARCH FOR NEW MESON AND BARYON RESONANCES

SATC: CORE: SMALL: LANGUAGE ABSTRACTIONS FOR RECONFIGURABLE HARDWARE MONITORS ON MANYCORE ARCHITECTURES

NUCLEAR PHYSICS EXPERIMENTS WITH THE ELECTRO-WEAK PROBE

CANCER STEM CELL PHENOTYPING: ESTABLISHING CORRELATIONS AND REGULATORY CROSSTALK BETWEEN MOLECULAR MARKERS AND MECHANICAL/RHEOLOGICAL PROPERTIES

AN EMISSION MICROSCOPY STUDY.

COMMUNITY CAPACITY

CONGRESSIONALLY DIRECTED SPENDING - SAVE AMERICAS TREASURES GRANTS AWARDED VIA CONGRESSIONALLY DIRECTED SPENDING PROVIDE PRESERVATION AND OR CONSERVATION ASSISTANCE TO NATIONALLY SIGNIFICANT HISTORIC PROPERTIES AND COLLECTIONS. GRANTS REQUIRE A DOLLAR-FOR-DOLLAR, NON-FEDERAL MATCH, WHICH CAN BE CASH OR DOCUMENTED IN-KIND. THE GRANT PROGRAM IS ADMINISTERED BY THE NATIONAL PARK SERVICE (NPS) IN PARTNERSHIP WITH THE NATIONAL ENDOWMENT FOR THE ARTS (NEA), THE NATIONAL ENDOWMENT FOR THE HUMANITIES (NEH), AND THE INSTITUTE OF MUSEUM AND LIBRARY SERVICES (IMLS). BENEFICIARIES INCLUDE STATES, TRIBES, LOCAL GOVERNMENTS, AND NONPROFITS. THIS PROJECT IS AWARDED TO THE INSTITUTE OF HIGHER EDUCATION, OHIO UNIVERSITY, FOR FLOOR, CEILING, AND WALL REPAIRS TO THE ATHENS STATE HOSPITAL, THE RIDGES.

RURAL COMMUNITIES OPIOID RESPONSE PROGRAM-PSYCHOSTIMULANT SUPPORT

COAL PLASTIC COMPOSITE PIPING INFRASTRUCTURE COMPONENTS

SECTOR-BASED STRATEGIES

WORKFORCE TRAINING

PARTNERSHIPS FOR ADAPTATION, IMPLEMENTATION AND DISSEMINATION (PAID): CAREER SUCCESS IN SCIENCE & ENGINEERING-RELATED FIELDS FOR FEMALE FACULTY AT

COAL-DERIVED ALTERNATIVES TO FIBER-CEMENTITIOUS BUILDING MATERIALS

SCIENCE OF ELECTRON-CONDUCTING FILAMENTS IN ION-CONDUCTING CHALCOGENIDE GLASSES

STUDY OF THE ELECTRO-WEAK STRUCTURE OF THE NUCLEON

SHF: MEDIUM: COLLABORATIVE RESEARCH: SCALING ON-CHIP NETWORKS TO 1000-CORE SYSTEMS USING HETEROGENEOUS EMERGING INTERCONNECT TECHNOLOGIES

HIGH-THROUGHPUT ASSAYS CAN PROVIDE MIPRECEDENTED INSIGHTS TO THE BIOLOGIST INTERESTED IN UNDERSTANDING BIOPHYSICAL PROCESSES AND FUNCTIONAL NETWORKS.

THE APPALACHIAN OHIO HERBARIUM DATABASE NETWORK: INFRASTRUCTURAL ENHANCEMENTS, RESOURCE BUILDING AND DATABASE COMPLETION

COLLABORATIVE RESEARCH: THE PHYSIOLOGICAL AND BIOCHEMICAL UNDERPINNINGS OF THERMAL TOLERANCE IN ANTARCTIC NOTOTHENIOID FISHES

STUDY OF THE ELECTRO-WEAK STRUCTURE OF THE NUCLEON

THE STEWARDSHIP SCIENCE ACADEMIC ALLIANCES (SSAA) PROGRAM WAS ESTABLISHED IN 2002 TO SUPPORT STATE-OF-THE-ART RESEARCH AT U.S. ACADEMIC INSTITUTIONS IN AREAS OF FUNDAMENTAL PHYSICAL SCIENCE AND TECHNOLOGY OF RELEVANCE TO THE SSP MISSION. THE SSAA PROGRAM PROVIDES THE RESEARCH EXPERIENCE NECESSARY TO MAINTAIN A CADRE OF TRAINED SCIENTISTS AND ENGINEERS AT U.S. UNIVERSITIES TO MEET THE NATION’S CURRENT AND FUTURE SSP NEEDS, WITH A FOCUS ON THOSE AREAS NOT SUPPORTED BY OTHER FEDERAL AGENCIES. IT SUPPORTS THE DOE/NNSA’S PRIORITIES BOTH TO ADDRESS THE WORKFORCE SPECIFIC NEEDS IN SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS AND TO SUPPORT THE NEXT GENERATION OF PROFESSIONALS WHO WILL MEET THOSE NEEDS.

CUCURBITURILS AND GLYCOLURIL-BASED BASKETS MIMICKED BY HARD SPHERE FLUIDS: A NOVEL MODEL APPLIED TO SUPRAMOLECULAR CATALYSIS IN WATER -WITH THE SUPPORT OF THE MACROMOLECULAR, SUPRAMOLECULAR AND NANOCHEMISTRY PROGRAM IN THE DIVISION OF CHEMISTRY, PROFESSOR ERIC MASSON OF OHIO UNIVERSITY WILL DEVELOP A NEW THEORETICAL MODEL TO QUANTIFY THE STRENGTH OF INTERACTIONS BETWEEN SYNTHETIC HOST MOLECULES AND SMALL MOLECULE GUESTS, WHEN BOTH HOST AND GUEST ARE DISSOLVED IN WATER. THIS RESEARCH AIMS TO GAIN FUNDAMENTAL CHEMISTRY KNOWLEDGE IMPORTANT FOR UNDERSTANDING MOLECULAR INTERACTIONS IN BIOLOGICAL SYSTEMS AND FOR INFORMING THE DESIGN OF NEW SELECTIVE AND POTENT DRUGS. MASSON WILL ALSO USE THIS MODEL TO IDENTIFY GUEST MOLECULES THAT ARE MOST LIKELY TO REACT WITH EACH OTHER INSIDE THE HOST MOLECULES. THE HOST MOLECULES WILL THUS BECOME MINIATURE VESSELS THAT WILL CATALYZE THESE REACTIONS. THE PROJECT WILL EXPOSE STUDENTS TO CORE THEORETICAL ORGANIC CHEMISTRY CONCEPTS, TO SYNTHETIC CHEMISTRY ESPECIALLY WITH THE PREPARATION OF NEW BASKET-SHAPED HOSTS, TO MOLECULAR MODELING, AND TO ANALYTICAL CHEMISTRY TECHNIQUES. MASSON WILL ALSO ENGAGE IN DOMESTIC AND INTERNATIONAL COLLABORATIVE PROGRAMS THAT HE SPEARHEADED IN SPAIN, FRANCE, GERMANY AND THE CZECH REPUBLIC, AS WELL AS OUTREACH ACTIVITIES AT ENGLISH-FRENCH BILINGUAL HIGH SCHOOLS IN THE US. THE CHOSEN HOSTS WILL BE CUCURBITURILS, A FAMILY OF HOLLOW, PUMPKIN-SHAPED MOLECULES THAT CAN TIGHTLY ENCAPSULATE GUEST MOLECULES; AND TAILOR-MADE MOLECULES RESEMBLING EMPTY BASKETS. TO QUANTIFY INTERMOLECULAR INTERACTIONS, THE MASSON TEAM WILL MIMIC HOST MOLECULES WITH HARD-SPHERE FLUIDS OF LOW POLARITY. THE UNIQUE ADVANTAGE OF THIS MODEL IS THAT IT DOES NOT INVOKE THE HOST STRUCTURE EXPLICITLY. THE ONLY REQUIRED INPUT IS THE VOLUME OF THE GUEST, AND ITS FREE ENERGY OF SOLVATION IN BOTH WATER AND THE LOW POLARITY SOLVENT; BOTH SOLVATION ENERGIES WILL BE CALCULATED RAPIDLY. THE SCOPE AND LIMITATIONS OF THIS MODEL WILL BE THOROUGHLY TESTED AS PART OF AIM 1. IN AIM 2, THE SELECTIVITY AND PACKING PREDICTIONS FROM THE MODEL WILL BE USED TO IDENTIFY SUITABLE REACTION PARTNERS INSIDE HOSTS. IN AIM 3, A NEW FAMILY OF GLYCOLURIL-BASED BASKETS FOR NEUTRAL AND POSITIVELY CHARGED AMPHIPHILIC GUEST RECOGNITION IN WATER WILL BE SYNTHESIZED. THE FLEXIBILITY AND PHYSICO-CHEMICAL PROPERTIES OF THE HOSTS ARE EXPECTED TO BE HIGHLY TUNABLE. THE HARD-SPHERE FLUID MODEL WILL BE TESTED AGAIN TOWARD THESE HOSTS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

CONSEQUENCES OF LIPID RESTRUCTURING DURING TEMPERATURE VARIATION ON THE SUSCEPTIBILITY OF BIOLOGICAL MEMBRANES TO LIPID PEROXIDATION

FY 2015 YALI CONNECT CAMPS PROGRAM

STRANGE MESON AND BARYON PHOTOPRODUCTION

THE PROPOSED PROJECT WILL MONITOR AND MODEL THE IMPACT OF AIR EMISSIONS ON THE ENVIRONMENT AND PUBLIC HEALTH AND ALSO DEVELOP TOOLS FOR PLANNING AND

INTEGRATED AVIONICS TECHNOLOGY DEVELOPMENT

INTERGOVERNMENTAL MOBILITY ASSIGNMENT

MAINTENANCE OF AN ALTERNATIVE REPRODUCTIVE STRATEGY IN THE SWORDTAIL XIPHOPHORUS MULTILINEATUS

NEURAL CODING OF SOUND LOCATION UNDER NORMAL AND IMPAIRED HEARING CONDITIONS

CDS&E: CONTROLLING PROTEIN - PROTEIN INTERACTIONS: COMPUTATIONS AND EXPERIMENTS

THE ROLE OF APOLIPOPROTEIN AIV IN LIPID-INDUCED THERMOGENESIS VIA SYMPATHETIC ACTIVITY

PROMISE NEIGHBORHOODS