Coalition For National Trauma Research

A NATIONAL COORDINATING CENTER FOR TRAUMA RESEARCH

'THE PATHOGENESIS OF POST-TRAUMATIC PULMONARY EMBOLISM: A PROSPECTIVE MULTI-CENTER INVESTIGATION BY THE CLOTT STUDY GROUP'

MULTIINSTITUTIONAL MULTIDISCIPLINARY INJURY MORTALITY INVESTIGATION IN THE CIVILIAN PRE-HOSPITAL ENVIRONMENT (MIMIC)

PLASMA RESUSCITATION WITHOUT LUNG INJURY (PROPOLIS)

A NATIONAL COORDINATING CENTER FOR PREHOSPITAL TRAUMA RESEARCH FUNDING TRANSFUSION USING STORED FRESH WHOLE BLOOD

A NATIONAL COORDINATING CENTER FOR PREHOSPITAL TRAUMA RESEARCH FUNDING: DETECTION AND MANAGEMENT OF NONCOMPRESSIBLE HEMORRHAGE USING VENA CAVA ULTRAS

18 MONTH NO COST EXTENSION

DESIGN FOR IMPLEMENTATION: THE FUTURE OF TRAUMA RESEARCH AND CLINICAL GUIDANCE - PROGRAM DIRECTOR/PRINCIPAL INVESTIGATOR: LAGRONE, LACEY N. PROJECT SUMMARY/ABSTRACT INJURY ACCOUNTS FOR 47% OF DEATHS IN AMERICANS AGES 1-46, AND IS ASSOCIATED WITH AN ANNUAL $672 BILLION COST IN HEALTHCARE EXPENSES AND LOST PRODUCTIVITY. INJURY OUTSTRIPS CANCER, DIABETES, AND HEART DISEASE IN PREVALENCE AND COST (1-2). THERE REMAINS VAST INEQUITY IN ACCESS TO QUALITY INJURY CARE, WITH AN ESTIMATED ONE-IN-FIVE TRAUMA DEATHS BEING PREVENTABLE. THE CURRENT STATE OF AFFAIRS FOR TRAUMA KNOWLEDGE TRANSFER LEAVES MANY TRAUMA PROVIDERS WITH INADEQUATE ACCESS TO UP-TO-DATE, RESOURCE-RELEVANT, USER-FRIENDLY, TRUSTWORTHY CLINICAL GUIDANCE. THE PUBLIC DOMAIN CONTAINS REDUNDANCY AND GAPS IN THE EXISTING CLINICAL PRACTICE GUIDANCE, WHICH IS DEVELOPED PRIMARILY BY AND OFTEN PRIMARILY FOR, ACADEMIC LEVEL I TRAUMA CENTERS, WITHOUT REPRESENTATION OF GEOGRAPHY, DISCIPLINE, OR CULTURAL DIVERSITY IN ORIGIN OR APPLICABILITY. THE 2016 NATIONAL ACADEMIES OF SCIENCE, ENGINEERING AND MEDICINE REPORT ON A NATIONAL TRAUMA CARE SYSTEM ACKNOWLEDGED THAT A “LACK OF FORMAL, FUNDED MECHANISMS FOR COORDINATION, COMMUNICATION, AND TRANSLATION IN TRAUMA CARE HAS…CONTRIBUTED…TO SUBOPTIMAL OUTCOMES FOR INJURED PATIENTS IN THE UNITED STATES (5).” THE THREE-YEAR CONFERENCE SERIES, DESIGN FOR IMPLEMENTATION: THE FUTURE OF TRAUMA RESEARCH AND GUIDANCE WILL APPLY BEST PRACTICES FROM DISSEMINATION AND IMPLEMENTATION SCIENCE, AGILE TEAM FACILITATION, AND ADULT LEARNING THEORIES TO INCLUSIVELY ENGAGE STAKEHOLDERS IN ORDER TO BETTER UNDERSTAND USER NEEDS, AND TO ULTIMATELY DEVELOP A NATIONAL STRATEGY FOR CLINICAL GUIDANCE DEVELOPMENT AND DISSEMINATION. THE CONFERENCE WILL LEVERAGE THE EXPERTISE, PERSPECTIVE, AND POSITION OF LEADERS AND END-USERS WITH GLOBAL EXPERTISE IN DISSEMINATION AND IMPLEMENTATION SCIENCE, HOSPITAL ADMINISTRATION, DEVELOPMENT, CLINICAL CARE, INFORMATICS AND PATIENT EXPERIENCE. THE CONFERENCE SERIES WILL FOLLOW IMPLEMENTATION SCIENCE PRINCIPLES IN STRUCTURE, WITH EACH YEAR HAVING AN EDUCATION, DATA ACQUISITION, AND EXECUTION FOCUS. THE FIRST YEAR WILL FOCUS ON CONTEXT INQUIRY AND STAKEHOLDER ENGAGEMENT, SECOND ON PERCEPTUAL IMPLEMENTATION OUTCOMES (ACCEPTABILITY, APPROPRIATENESS, FEASIBILITY), AND THE FINAL YEAR ON BEHAVIORAL IMPLEMENTATION OUTCOMES (ADOPTION, FIDELITY, SUSTAINABILITY). THE CONFERENCE SERIES IS INTENDED TO INFORM DEVELOPMENT OF A NATIONAL PLAN, FOR WHICH ADDITIONAL FUNDING, SUCH AS A DISSEMINATION PRACTICE GRANT, WILL BE SOUGHT. PAGE CONTINUATION FORMAT PAGE

SUMMIT ON THE ADVANCEMENT OF FOCUSED EQUITY RESEARCH IN TRAUMA (SAFER-TRAUMA) - PROGRAM DIRECTOR/PRINCIPAL INVESTIGATOR: HO, VANESSA PROJECT SUMMARY/ABSTRACT TRAUMA, OR PHYSICAL INJURY FROM MECHANISMS SUCH AS MOTOR VEHICLE CRASHES, VIOLENCE, OR FALLS, IS THE LEADING CAUSE OF DEATH FOR AMERICANS UNDER AGE 46.(1) IN 2016, A REPORT FROM THE NATIONAL ACADEMY OF SCIENCES ENGINEERING AND MEDICINE (NASEM) ESTIMATED THAT AS MANY AS 20% OF ALL DEATHS FROM TRAUMA MAY BE PREVENTED WITH OPTIMAL TRAUMA CARE, WHICH TRANSLATES TO NEARLY 300,000 LIVES SAVED OVER TEN YEARS.(2) IN AN IDEAL CIRCUMSTANCE, TRAUMA CARE SHOULD BE “THE GREAT EQUALIZER” – TRAUMA CARE SHOULD BE PROVIDED TO ALL WHO PRESENT WITH INJURIES, REGARDLESS OF INSURANCE STATUS, SKIN COLOR, OR OTHER FACTORS. HOWEVER, RESEARCH IN TRAUMA POPULATIONS OVER THE LAST FIFTEEN YEARS HAS LARGELY DEMONSTRATED THAT POOR OUTCOMES AFTER INJURY DISPROPORTIONATELY AFFECT AMERICANS FROM UNFAIRLY DISADVANTAGED RACIAL AND ETHNIC MINORITY GROUPS, RURAL AND INNER-CITY RESIDENTS, ECONOMICALLY MARGINALIZED GROUPS, CHILDREN, AND OLDER ADULTS.(3) DESPITE RESEARCH DEMONSTRATING THAT DISPARITIES ARE PRESENT, PERVASIVE, AND PERSISTENT IN TRAUMA, WE HAVE NOT YET DEVELOPED UNIFIED STRATEGIES TO ADDRESS, REDUCE, AND ELIMINATE HEALTH INEQUITIES. IN COLLABORATION WITH THE COALITION FOR NATIONAL TRAUMA RESEARCH (CNTR), A CONFERENCE TITLED THE SUMMIT ON THE ADVANCEMENT OF FOCUSED EQUITY RESEARCH IN TRAUMA (SAFER-TRAUMA) WILL GENERATE RESEARCH STRATEGIES TO IDENTIFY TRAUMA-RELATED HEALTH INEQUITIES, ELUCIDATE THEIR UNDERLYING CAUSES, AND DEVELOP INNOVATIVE INTERVENTIONS TO ADDRESS, REDUCE, AND ELIMINATE THEM. THIS PROPOSED SUMMIT WILL CONVENE KEY STAKEHOLDERS TO ILLUSTRATE HEALTH INEQUITIES IN TRAUMA, HIGHLIGHT RELEVANT CURRENT RESEARCH, AND ADDRESS THE FOLLOWING AIMS: 1) CHARACTERIZE CURRENT GAPS REGARDING RESEARCH IN HEALTH EQUITY IN TRAUMA, 2) IDENTIFY FUNDING MECHANISMS AND PATHWAYS FOR COLLABORATION, AND 3) OUTLINE A RESEARCH AGENDA TO ADDRESS INEQUITIES IN TRAUMA. THE SUMMIT IS BEING ORGANIZED BY THE CNTR EQUITY DIVERSITY AND INCLUSION COMMITTEE, WHICH COMPRISES REPRESENTATIVES FROM ALL THE MAJOR NATIONAL TRAUMA ORGANIZATIONS WHO ARE PASSIONATE ABOUT TRAUMA OUTCOMES, RESEARCH, AND EQUITY. THE REACH OF THE ORGANIZING COMMITTEE WILL ALLOW FOR THE ENGAGEMENT OF CLINICIANS, RESEARCHERS, AND STAKEHOLDERS TO PRIORITIZE RESEARCH INTO HEALTH INEQUITIES VIA AN INTERDISCIPLINARY AND COLLABORATIVE NETWORK AND DEVELOP AN ACTIONABLE RESEARCH AGENDA. THESE COLLABORATIONS WILL LAY THE FOUNDATION TO TEST, DISSEMINATE, AND ASSESS EFFECTIVE PRACTICES TO IDENTIFY HEALTH INEQUITIES IN TRAUMA CARE, ELUCIDATE THEIR UNDERLYING CAUSES, AND DEVELOP INTERVENTIONS. PAGE CONTINUATION FORMAT PAGE

2021 CONSENSUS CONFERENCE TO IMPLEMENT OPTIMAL VTE PROPHYLAXIS IN TRAUMA - PROGRAM DIRECTOR/PRINCIPAL INVESTIGATOR (LAST, FIRST, MIDDLE): COSTANTINI, TODD W & HAUT, ELLIOTT R THE PROPOSED 2021 CONSENSUS CONFERENCE TO IMPLEMENT OPTIMAL VTE PROPHYLAXIS IN TRAUMA WILL CONVENE A MULTIDISCIPLINARY GROUP OF ESTABLISHED AND JUNIOR SCIENTISTS AND PRACTITIONERS IN AN INTERACTIVE FORUM (IN-PERSON AND ONLINE) DURING WHICH THE CURRENT STATE AND FUTURE OF THE SCIENCE ON VENOUS THROMBOEMBOLISM (VTE) PROPHYLAXIS WILL BE PRESENTED. VTE, WHICH INCLUDES BOTH DEEP VEIN THROMBOSIS (DVT) AND PULMONARY EMBOLISM (PE), IS A SIGNIFICANT CAUSE OF MORBIDITY AND MORTALITY FOR PATIENTS FOLLOWING MAJOR TRAUMA. IMPROVING PATIENT OUTCOMES BY DECREASING VTE RATES IN TRAUMA PATIENTS WILL REQUIRE IMPLEMENTATION OF EVIDENCE-BASED RECOMMENDATIONS, OPTIMIZATION OF CURRENT CARE PATHWAYS, AND DEVELOPMENT OF NOVEL THERAPEUTIC STRATEGIES FOR PHARMACOLOGIC PROPHYLAXIS IN THE FUTURE. THE CONFERENCE PRIMARY OBJECTIVES ARE TO PROMOTE RESEARCH RELATED TO DELIVERING TIMELY PHARMACOLOGIC VTE PROPHYLAXIS, TO SUPPORT THE DEVELOPMENT OF EDUCATION PLATFORMS AND CLINICAL CARE PATHWAYS TO IMPROVE IMPLEMENTATION OF CURRENT GUIDELINES, AND TO DEVELOP FUTURE RESEARCH OBJECTIVES FOR VTE PROPHYLAXIS IN TRAUMA. THE CONFERENCE AIMS ARE TO: 1) DEFINE GUIDELINES FOR VTE PROPHYLAXIS IN HIGH-RISK TRAUMA PATIENTS THAT ARE ACCEPTED BY TRAUMA CLINICIANS, SURGICAL SUBSPECIALISTS, NURSES, PHARMACISTS, AND ALL SPECIALISTS WHO PROVIDE CARE TO INJURED PATIENTS; 2) DISSEMINATE THESE GUIDELINES TO RESPECTIVE SPECIALTY ORGANIZATIONS; 3) ADDRESS CHALLENGES TO THE DISSEMINATION AND IMPLEMENTATION OF THESE GUIDELINES ACROSS HEALTHCARE SYSTEMS; 4) DEFINE RESEARCH PRIORITIES TO MEASURE SHORT- AND LONG-TERM OUTCOMES FOR INJURED PATIENTS AT RISK FOR VTE, STUDY THE IMPLEMENTATION OF CONSENSUS GUIDELINES, AND INVESTIGATE NOVEL PHARMACOLOGIC APPROACHES TO VTE PROPHYLAXIS; 5) INTEGRATE THE VOICE OF INJURED PATIENTS AND PEOPLE WITH VTE TO PROMOTE TRULY PATIENT-CENTERED CARE RESEARCH; 6) PROVIDE AN OPPORTUNITY TO ENGAGE JUNIOR INVESTIGATORS, WOMEN, AND UNDERREPRESENTED MINORITIES INTERESTED IN TRAUMA AND VTE TO ENSURE THE PIPELINE OF A DIVERSE GROUP OF INVESTIGATORS AND SPUR NEW GRANT APPLICATIONS. TO ENCOURAGE ATTENDANCE BY JUNIOR INVESTIGATORS AND TRAINEES, 5 JUNIOR INVESTIGATOR TRAVEL AWARDS WILL BE MADE TO COVER TRAVEL AND REGISTRATION EXPENSES. THE OFFERING OF THESE AWARDS WILL BE ANNOUNCED THROUGH THE COALITION FOR NATIONAL TRAUMA RESEARCH’S MEMBER ORGANIZATIONS (TO THEIR MORE THAN 14,000 MEMBERS) AND RELATED PROFESSIONAL ORGANIZATIONS COMPRISING UNDERREPRESENTED SCIENTISTS AND PRACTITIONERS. AWARDEES WILL BE ENCOURAGED TO PARTICIPATE AS AUTHORS IN THE PREPARATION OF THE CONFERENCE PROCEEDINGS FOR PUBLICATION. ROUNDTABLE DISCUSSIONS AND NETWORKING ACTIVITIES ARE INCLUDED IN THE CONFERENCE AGENDA TO FACILITATE INTERACTION BETWEEN JUNIOR AND SENIOR PARTICIPANTS. THE CONFERENCE WILL ALIGN WITH NHLBI’S OVERARCHING STRATEGIC VISION TO: “DEVELOP AND OPTIMIZE NOVEL DIAGNOSTIC AND THERAPEUTIC STRATEGIES TO PREVENT, TREAT, AND CURE HLBS DISEASES” (OBJ. 5), TO “OPTIMIZE CLINICAL AND IMPLEMENTATION RESEARCH TO IMPROVE HEALTH AND REDUCE DISEASE” (OBJ. 6), AND TO “FURTHER DEVELOP, DIVERSIFY, AND SUSTAIN A SCIENTIFIC WORKFORCE CAPABLE OF ACCOMPLISHING THE NHLBI’S MISSION” (OBJ. 7). OMB NO. 0925-0001/0002 (REV. 03/2020 APPR TO 02/28/2023) PAGE 1 CONTINUATION FORMAT PAGE