Light Inc

RUS IRA NEW ERA GRANT

TAS::89 0328::TAS RECOVERY ACT - SMART GRID INVESTMENT GRANT PROGRAM

LIGHTWEIGHT AND MODERN METALS MANUFACTURING INNOVATION (LM3I) INSTITUTE

BIPARTISAN INFRASTRUCTURE LAW (BIL)- SMART POWER AUTOMATION FOR RURAL COMMUNITIES IN WISCONSIN

PROJECT AIMS TO FURTHER DEVELOP INTEGRATED AND INNOVATIVE SERVICE APPROACHES ACROSS THE 90-90-90 CASCADE THAT ARE TAILORED TO THE DIVERSE NEEDS OF VARIOUS GROUPS OF PLHIV TO ATTAIN EPIDEMIC CONTROL

TAS::89 0328::TAS RECOVERY - SGIG - 09-0072: THE PROJECT FOCUSES ON CUSTOMER SYSTEMS , ADVANCED METERING INFRASTRUCTURE ( AMI ) AND ELECTRIC DIST

HEALTH CENTER CLUSTER

ACHIEVING HIV EPIDEMIC CONTROL THROUGH SCALING UP QUALITY TESTING, CARE AND TREATMENT IN MALAWI UNDE

HEALTH CENTER CLUSTER

THE COLUMBIA ENERGY STORAGE PROJECT WILL DEMONSTRATE A GRID-TIED 18MW COMPRESSED CO2 ENERGY STORAGE SYSTEM AT THE SITE OF A RETIRING COAL FIRED POWER STATION. THE DEMONSTRATION OF THIS TECHNOLOGY WILL BE A FIRST OF ITS KIND IN THE US.

FLORIDA POWER LIGHT IS PROPOSING A SMART GRID MANHOLE AND VAULT MONITORING PROJECT (MVMP) TO ENHANCE SMART GRID DEPLOYMENT AND IMPROVE RESILIENCY WITHIN THE VAULT AND MANHOLE PORTION OF THE ELECTRIC GRID ACROSS THE STATE OF FLORIDA. REMOTE MONITORING OF VAULTS IS NOT CURRENTLY A STANDARD UTILITY INDUSTRY PRACTICE. FLORIDA POWER LIGHT BELIEVES IN USING SIMPLE AND PROVEN METHODS, LIKE THOSE USED IN SUBSTATIONS, WITHIN THE TRANSFORMER VAULTS TO CAPTURE DATA, MONITOR EQUIPMENT, AND CREATE OPERATIONAL ACTION ITEMS. IMPROVED SITUATIONAL AWARENESS WILL INCREASE RESILIENCY AND RELIABILITY OF THE ELECTRIC GRID ENHANCING FPL’S SMART GRID CAPABILITIES OF THE ELECTRIC GRID.

HEALTH CENTER CLUSTER

LIGHTHOUSE CENTERS OF EXCELLENCE FOR COMPREHENSIVE INTEGRATED HIV CARE AND TREATMENT SERVICES IN MALAWI UNDER THE PRESIDENT'S EMERGENCY PLAN FOR AIDS RELIEF (PEPFAR) - BACKGROUND MALAWI HAS AN ESTIMATED HIV PREVALENCE OF 7.7% IN ADULTS AND 15,000 NEW INFECTIONS PER YEAR. THE COUNTRY MADE GREAT STRIDES TOWARDS ACHIEVING THE UNAIDS 95-95-95 TARGETS THROUGH A MULTI-SECTORAL APPROACH. TO STAY ON THIS SUCCESSFUL PATH, MALAWI HIV PROGRAM MUST APPLY MORE EFFORTS IN TARGETED TESTING FOR HIGH-RISK GROUPS, LINKING THEM TO CARE, SCALE-UP DIFFERENTIATED SERVICE DELIVERY MODELS, ADEQUATE SCREENING, AND MANAGEMENT OF ADVANCED HIV DISEASE (AHD), OPTIMIZE VIRAL LOAD (VL) MANAGEMENT, AND MITIGATE THE EFFECT OF OTHER PUBLIC HEALTH THREATS ON HIV SERVICES. LIGHTHOUSE TRUST, AN INDIGENOUS MALAWIAN ORGANIZATION, IS STRATEGICALLY POSITIONED TO ADDRESS CHALLENGES IN HIV CARE THROUGH A HOLISTIC, DATA-DRIVEN, AND LOCALLY TAILORED APPROACH. OVER THE PAST DECADES, LH ESTABLISHED CENTERS OF EXCELLENCE IN HIV CARE IN MALAWI REFERRAL HOSPITALS AND NOW OPERATES FIVE COES ACROSS THE COUNTRY IN ALL MAJOR CITIES. IN ADDITION, LH PROVIDES DIRECT SERVICE DELIVERY AND TECHNICAL SUPPORT TO PROTOTYPE FACILITIES IN LILONGWE WHICH INCLUDES EIGHT GOVERNMENT FACILITIES AND TWO PRISONS. PURPOSE THE PURPOSE OF THIS PROJECT IS TO DELIVER HIGH-IMPACT HIV TESTING AND TREATMENT SERVICES TO SUSTAIN ACHIEVEMENTS, GROW THE COHORT OF PLHIV ON ART, AND REACH THE 95-95-95 TARGETS. TO ACHIEVE THIS, LH PLANS TO CONTINUE OPERATING COES AT ALL REFERRAL HOSPITALS, IN MALAWI. THE PROJECT WILL THUS SUPPORT TERTIARY-LEVEL HIV CARE, FOCUSING ON AHD, HIV-ASSOCIATED CANCERS AND NON-COMMUNICABLE DISEASES (NCDS). MALAWI HEALTH SYSTEMS FOR HIV CARE WILL BE STRENGTHENED THROUGH MENTORSHIP, DEVELOPING MODEL INTERVENTIONS AND DIRECT SERVICE DELIVERY FOR THE PROTOTYPE FACILITIES. THUS, THE MAIN STRATEGIES OF THIS PROJECT ARE TO: OPTIMIZE STATUS-NEUTRAL TESTING SERVICES WITH IDENTIFICATION OF UNDIAGNOSED PLHIV (1ST 95) AND REFERRAL OF THE UNINFECTED FOR BIOMEDICAL PREVENTIVE SERVICES. ENSURE LINKAGE TO QUALITY CARE (2ND 95) AND OPTIMAL TREATMENT, RETENTION, AND VIRAL LOAD MONITORING (3RD 95) OF PLHIV. PROVIDE PATIENT-CENTERED, HIGH-QUALITY ADVANCED HIV TREATMENT SERVICES INCLUDING DIFFERENTIATED SERVICE DELIVERY MODELS AND INTEGRATED CARE AT ALL COES. SUPPORT THE NATIONAL ART PROGRAM THROUGH IMPLEMENTATION OF MODEL INTERVENTIONS IN PROTOTYPE CLINICS AND HEALTH-SYSTEM STRENGTHENING ACTIVITIES BEYOND COE CARE. OUTCOMES THE LONG-TERM OUTCOME OF THIS PROJECT IS THE ATTAINMENT OF THE UNAIDS 95-95-95 GOALS IN THE PROPOSED PROJECT DISTRICTS FOR ALL AGES, GENDERS, AND POPULATION GROUPS AT RISK FOR HIV INFECTION. LIGHTHOUSE WILL UNSURE THAT THAT ALL HEALTH EQUITY GAPS ARE ADDRESSED, AND EVIDENCE-BASED HIV PREVENTION INTERVENTIONS ARE OFFERED TO ALL POPULATION GROUPS. LIGHTHOUSE (LH) HAS OUTLINED A SERIES OF PRIORITIES TO IMPROVE HIV CASE FINDING, TREATMENT AND PREVENTION. THESE PRIORITIES INCLUDE INCREASING THE UPTAKE AND CONTINUITY OF PREP AMONG HIGH-RISK INDIVIDUALS AND USING TARGETED TESTING STRATEGIES TO IDENTIFY MORE UNDIAGNOSED HIV-POSITIVE INDIVIDUALS, WITH A PARTICULAR EMPHASIS ON CHILDREN 0 TO 14 YEARS, MEN, AND THE YOUTH. FURTHERMORE, LH WILL INCREASE ART COHORT GROWTH, DECREASE ATTRITION AMONG NEW ART INITIATES, AND INCREASE VIRAL LOAD SUPPRESSION ACROSS ALL AGE AND SEX GROUPS THROUGH THE VARIOUS PATIENT AND PEOPLE-CENTERED APPROACHES TO HEALTH SERVICE DELIVERY. TO SUPPORT THESE EFFORTS, LH STRENGTHEN COLLABORATION THE WITH THE MINISTRY OF HEALTH, DEPARTMENT OF HIV AND AIDS AS WELL AS HOSPITAL LEADERSHIP OF THE TERTIARY HOSPITALS AND PROTOTYPE FACILITIES. LH WILL CONTINUE BUILDING CAPACITY THROUGH CLINICAL MENTORSHIP, USING THE ESTABLISHED CASE-BASED TRAINING PLATFORM (PROJECT ECHO) TO ENSURE QUALITY SERVICES ARE BEING ALWAYS OFFERED. LH WILL USE DATA-DRIVEN QUALITY IMPROVEMENT (QI) INTERVENTIONS TO REFINE THE IMPLEMENTATION OF THESE ACTIVITIES.

EXPANDING THE UNITED STATES MANUFACTURING TECHNOLOGY AND TALENT ECOSYSTEM THROUGH THE LIFTDOD MII ACCELERATOR FOR U.S. NATIONAL SECURITY, INNOVATION, ECONOMIC GROWTH AND SUPPLY CHAIN RESILIENCY

TO PROVIDE VITAL HEALTH, NUTRITION, AND WATER, SANITATION AND HYGIENE SERVICES TO THE MOST VULNERABLE POPULATION SUDAN

HEALTH CENTER CLUSTER

BIPARTISAN INFRASTRUCTURE LAW: GRID VISIBILITY PROGRAM (GVP): UNLOCKING SYSTEM-WIDE DATA TO BUILD A MORE RESILIENT AND EQUITABLE GRID. THE RECIPIENT WILL DEPLOY GRID ENHANCING TECHNOLOGIES (GETS), DYNAMIC LINE RATINGS (DLR), AND EDGE-COMPUTING DEVICES (ECD), IN THE RECIPIENT’S ELECTRIC SERVICE TERRITORY BY THE END OF THE PROJECT. THE DLR EQUIPMENT WILL BE INSTALLED ON UP TO SEVEN (7) TRANSMISSION LINES, AND UP TO THIRTY THOUSAND (30,000) ECDS WILL BE INSTALLED ACROSS COMMUNITIES IN ALLEGHENY AND BEAVER COUNTIES.

RECONNECT 100% GRANT INFRASTRUCTURE INVESTMENTS AND JOBS ACT

ORCAS POWER & LIGHT COOPERATIVE (OPALCO) IS A MEMBER-OWNED, NON-PROFIT ENERGY COOPERATIVE THAT DISTRIBUTES ENERGY TO 20 ISLANDS IN THE SAN JUAN ISLANDS AND WILL SERVE AS THE PROJECT LEAD AND SITE DEVELOPER. THE OPALCO TIDAL ENERGY PROJECT IN THE ROSARIO STRAIT PLANS TO DEVELOP A PILOT DEMONSTRATION SITE AND INSTALL ONE 2 MW TIDAL POWER GENERATOR THAT MEETS CURRENT LOCAL, STATE, AND FEDERAL REGULATORY REQUIREMENTS. THE OVERALL OBJECTIVE OF THIS PROJECT IS TO PERFORM THE RESEARCH AND DEVELOPMENT (R&D) ACTIVITIES THAT ARE NEEDED TO DEMONSTRATE COMMERCIAL VIABILITY, ENABLING THE PILOT DEMONSTRATION SITE TO BE TRANSITIONED INTO A COMMERCIAL PROJECT THAT CONTINUES OPERATION AND PROVIDES OPPORTUNITIES FOR FURTHER DEVELOPMENT OF THE DEMONSTRATION SITE INTO A LARGE (> 5 MW), GRID CONNECTED TIDAL ENERGY PROJECT. IN PHASE 1/ BP1, THE PROJECT TEAM WILL FULLY CHARACTERIZE THE SITE, WHICH WILL INVOLVE PHYSICAL AND DESK TOP DATA COLLECTION AND ANALYSIS. R&D IN THIS PHASE IS TO INFORM AND UNDERSTAND THE INTERACTIONS BETWEEN THE ONSHORE, OFFSHORE ENVIRONMENT AND THE TECHNOLOGY, THEREBY IMPROVING CONFIDENCE IN THE LEVEL OF RISK ASSOCIATED WITH THESE INTERACTIONS. PLANS AND SCHEDULES WILL BE DEVELOPED FOR LICENSING AND ENVIRONMENTAL MONITORING, SITE HEALTH AND SAFETY, STAKEHOLDER ENGAGEMENT, COMMUNITY BENEFITS, SUPPLY CHAIN PROCUREMENT AND FINALLY TECHNOLOGY SELECTION AND QUALIFICATION. THIS PHASE WILL CULMINATE IN A FEDERAL ENERGY REGULATORY COMMISSION (FERC) DRAFT HYDROKINETIC LICENSE APPLICATION SUBMISSION. A COMPETITIVE DOWN-SELECT WILL BE HELD AT THE CONCLUSION OF PHASE 1/BP1 WHERE THE PROJECT TEAM WILL PRESENT THE PROJECT GOALS, PROGRESS, AND ACCOMPLISHMENTS TO-DATE TO THE WATER POWER TECHNOLOGIES OFFICE (WPTO). IF THIS PROJECT IS SELECTED, SUBSEQUENT PHASES WILL BE AS FOLLOWS: - PHASE 2: DETAILED SITE CHARACTERIZATION - PHASE 3: SITE MOBILIZATION - PHASE 4: SITE COMMISSIONING AND TECHNOLOGY FABRICATION - PHASE 5: TESTING AND OPERATIONS

TO PROVIDE VITAL MULTISECTORAL ASSISTANCE FOR CONFLICT-AFFECTED POPULATION IN SUDAN.

FOREIGN ASSISTANCE: PRIMARY HEALTH CARE, NURTRITION AND WASH SERVICES

A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF LHP588 IN SUBJECTS WITH P. GINGIVALIS-POSITIVE ALZHEIMER'S DISEASE - SUMMARY/ABSTRACT A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF LHP588 IN SUBJECTS WITH P. GINGIVALIS-POSITIVE ALZHEIMER'S DISEASE GIVEN THE INCREASING INCIDENCE OF AD WORLDWIDE, THERE IS AN URGENT UNMET NEED FOR PRECISION MEDICINE APPROACHES THAT COULD PREVENT OR DELAY COGNITIVE DECLINE EXPERIENCED BY ALZHEIMER’S DISEASE (AD) PATIENTS. MOUNTING EVIDENCE SUGGESTS THAT LIFE EXPOSURE TO BRAIN-PENETRANT PATHOGENS COULD CONTRIBUTE TO THE ETIOLOGY OF AD. ONE MICROBIAL AGENT RECENTLY ASSOCIATED WITH AD IS PORPHYROMONAS GINGIVALIS (PG). PG IS BEST KNOWN FOR ITS ROLE IN CHRONIC PERIODONTITIS , BUT EPIDEMIOLOGIC AND OTHER STUDIES ALSO STRONGLY IMPLY ITS CONTRIBUTION TO COGNITIVE DECLINE. CRITICALLY, PG VIRULENCE FACTORS, PROTEASES CALLED GINGIPAINS HAVE BEEN IDENTIFIED IN POST-MORTEM AD BRAINS, AT RATES SIGNIFICANTLY HIGHER THAN AGE-MATCHED CONTROLS. GINGIPAIN LOADS HAVE SHOWN A POSITIVE CORRELATION WITH AD SEVERITY, BRAIN TAU LEVELS, AND UBIQUITIN PATHOLOGY. OUR TEAM PREVIOUSLY DEVELOPED A SMALL-MOLECULE, BRAIN-PENETRANT, ORALLY BIOAVAILABLE, FIRST-GENERATION, COVALENT GINGIPAIN INHIBITOR CALLED COR388 (ATUZAGINSTAT), WHICH MITIGATED MANY AD- ASSOCIATED NEUROPATHOLOGICAL FEATURES IN PRECLINICAL IN VITRO AND ANIMAL STUDIES. AFTER OBTAINING U.S. FOOD & DRUG ADMINISTRATION (FDA) PERMISSION, WE CONDUCTED A LARGE, PHASE-II/III, PLACEBO-CONTROLLED, RANDOMIZED CLINICAL TRIAL OF ATUZAGINSTAT ADMINISTERED TO MILD-TO-MODERATE DEMENTIA SUBJECTS (MMSE RANGING 12-24) FOR 48 WEEKS. TARGET ENGAGEMENT WAS VERIFIED ALONG WITH DOSE-DEPENDENT REDUCTION OF SYSTEMIC PG INFECTION. THE PRESPECIFIED SUBGROUP ANALYSIS MOST RELEVANT TO THE MECHANISM OF ACTION INDICATED DOSE-DEPENDENT EFFICACY IN PATIENTS WITH PG-POSITIVE (PG+) SALIVA (N=242), WITH A REDUCTION OF THE AD ASSESSMENT SCALE-COGNITIVE SUBSCALE 11 (ADAS-COG11) SCORES BY 57% COMPARED TO BASELINE (P=0.02). HOWEVER, BECAUSE OF HEPATIC SAFETY CONCERNS, DEVELOPMENT OF ATUZAGINSTAT WAS DISCONTINUED. WE, AT LIGHTHOUSE PHARMACEUTICALS, HAVE NOW DEVELOPED A SECOND-GENERATION, ORALLY BIOAVAILABLE GINGIPAIN INHIBITOR CALLED LHP588. RIGOROUS IN VITRO AND ANIMAL STUDIES HAVE DEMONSTRATED IMPROVED TARGET ENGAGEMENT AND REDUCED TOXICITY OF LHP588 COMPARED TO ATUZAGINSTAT. IN A PHASE I STUDY COMBINING A SINGLE-ASCENDING-DOSE AND A 10-DAY MULTIPLE-ASCENDING-DOSE, LHP588 WAS WELL TOLERATED AND THERE WAS NO EVIDENCE OF HEPATIC TOXICITIES AT ANY DOSE. USING OUR EXPERIENCE WITH ATUZAGINSTAT AND THE DEVELOPMENT OF LHP588, WE FORMULATED THE HYPOTHESIS THAT LHP588 CAN PROVIDE INCREASED TARGET ENGAGEMENT WITH REDUCED SAFETY RISKS TO SLOW DOWN COGNITIVE DECLINE IN PATIENTS SUFFERING FROM PG-POSITIVE (PG+) MILD-TO-MODERATE AD. TO TEST OUR HYPOTHESIS, WE WILL DEPLOY A RIGOROUSLY DESIGNED PHASE II, DOUBLE-BLIND, PLACEBO-CONTROLLED, RANDOMIZED, 3-ARM, PARALLEL GROUP CLINICAL TRIAL TERMED SPRING (STOPPING PROGRESSION OF PORPHYROMONAS GINGIVALIS-ASSOCIATED AD). THOROUGH SCREENING WILL SELECT AD SUBJECTS WITH PG+ SALIVA AND PLASMA P-TAU-217 LEVELS ABOVE 0.42 PG/ML, WHICH IS ASSOCIATED WITH AMYLOID PLAQUE POSITIVITY ACROSS RACIAL AND ETHNIC GROUPS. ENROLLED STUDY PARTICIPANTS (N=300; MINIMUM OF 30% OF DIVERSE SUBJECTS) WILL BE RANDOMIZED 1:1:1 TO 25 OR 50 MG LHP588 TAKEN ORALLY ONCE-A-DAY, OR MATCHING PLACEBO, FOR 48 WEEKS. IMPORTANTLY, THE FDA PROVIDED A “STUDY MAY PROCEED” LETTER AFTER REVIEW OF OUR INVESTIGATIONAL NEW DRUG (IND) APPLICATION. IN AIM 1, WE WILL ASSESS SAFETY AND TOLERABILITY IN AD SUBJECTS ADMINISTERED LHP588. IN AIM 2, WE WILL TEST FOR TARGET ENGAGEMENT BY MEASURING PG DNA LEVELS IN SALIVA AND ANTI-PG IGG LEVELS IN SERUM. IN AIM 3, WE WILL DETERMINE DRUG EFFICACY VS. PLACEBO USING CLINICAL ASSESSMENTS OF DEMENTIA, I.E., COGNITION (ADAS- COG11, WHICH IS THE PRIMARY EFFICACY MEASURE), OTHER CLINICAL MEASURES, BIOMARKERS, INCLUDING BRAIN ATROPHY ESTIMATED BY VMRI, AND PLASMA LEVELS OF P-TAU-217. SUCCESS OF OUR SPRING TRIAL WILL WARRANT CARRYING OUT AT LEAST ONE LARGER CONFIRMATORY PHASE III STUDY FOR FUTURE

HEAD START

ADVANCING THE LIFT MANUFACTURING TECHNOLOGY & TALENT ECOSYSTEM FOR U.S. NATIONAL SECURITY, INNOVATION, ECONOMIC GROWTH AND SUPPLY CHAIN RESILIENCY

CENTER OF EXCELLENCE FOR COMPREHENSIVE INTEGRATED HIV CARE

THE BROADBAND INFRASTRUCTURE DEPLOYMENT PROJECT PROPOSES TO INSTALL FIBER DIRECTLY CONNECTING 586 UNSERVED NATIVE AMERICAN HOUSEHOLDS, AS WELL AS BUSINESSES AND GOVERNMENT ENTITIES, WITH FIBER TO THE HOME SERVICE OF 1 GBPS SYMMETRICAL. THE PROJECT PROPOSES THE FOLLOWING ACTIVITIES DESIGNED TO IMPROVE ACCESS TO, AND USE OF, BROADBAND SERVICES AMONG TRIBAL MEMBERS: INSTALL 2.1 MILES OF ELECTRIC AND FIBER OPTIC SUBMARINE CABLE AND 14 MILES OF OVERHEAD FIBER LINES WITHIN THE ANNETTE ISLAND RESERVE AND TO AND FROM THE MAINLAND COMMUNITY OF KETCHIKAN. INSTALL THE CORE NETWORK. PROVIDE CUSTOMER PREMISES EQUIPMENT TO EVERY LOCATION IN THE ANNETTE ISLAND RESERVE INCLUDING HOUSEHOLDS, BUSINESSES, AND GOVERNMENT ENTITIES. ESTABLISH A BROADBAND DIVISION WITHIN METLAKATLA POWER & LIGHT THIS PROJECT WILL: BRING 1 GBPS INTERNET SERVICE VIA FTTP WITHIN THE ANNETTE ISLAND RESERVE AND THE MAINLAND COMMUNITY OF KETCHIKAN INCLUDING HOUSEHOLDS, BUSINESSES, AND GOVERNMENT ENTITI

IMPROVING ACCESS TO BASIC ESSENTIAL SERVICES FOR IDPS AND HOST COMMUNITY POPULATIONS THROUGHOUT SOUTH DARFUR, SUDAN

TAS::89 0328::TAS RECOVERY - NEW AWARD TO FLORIDA POWER & LIGHTING COMPANY. RECOVERY ACT - WORKFORCE TRAINING FOR THE ELECTRIC POWER SECTOR. AWARD I

PROGRAM TO PROVIDE PRIMARY HEALTH CARE, NUTRITION, WASH, AND SHELTER SERVICES FOR CONFLICT-AFFECTED POPULATIONS IN SOUTH AND EAST DARFUR.

TO PROVIDE LIFESAVING HEALTH, NUTRITION, MPCA, WASH, AGRICULTURE, AND PROTECTION ASSISTANCE TO THE MOST VULNERABLE IN SOMALIA.

TAS::89 0328::TAS RECOVERY ACT. OBLIGATE FY 10 ARRA FUNDING IN THE AMOUNT OF $5,033,441.00

AGRICULTURAL SUPPORT IN DRC

PROVISION OF EMERGENCY HEALTH, NUTRITION, WATER, SANITATION, AND HYGIENE SERVICES TO CONFLICT-AFFECTED POPULATIONS IN SUDAN.

THE PURPOSE OF THIS AWARD IS TO PROVIDE FINANCIAL SUPPORT FOR A PROGRAM RESPONDING TO THE EMERGENCY NEEDS OF EARTHQUAKE-AFFECTED HAITIANS FOR A PERIO

INTEGRATED EMERGENCY SERVICES TO CONFLICT-AFFECTED IDPS IN SUDAN

ASILI 2.0 ¿ SCALING FOR SUSTAINABILITY IN THE KIVUS

STRENGTHENING INTEGRATED RESPONSE IN PROTECTION, WASH, AND SHELTER THROUGH LIFESAVING SERVICES TO AFFECTED POPULATIONS IN SOUTH SUDAN

HUMANITARIAN ASSISTANCE

HUMANITARIAN ASSISTANCE

NEW AWARD (GRANT) TO “ALIGHT” TO SUPPORT THE IMPLEMENTATION OF A PROTECTION PROGRAM IN ETHIOPIA.

CONTINUATION OF PRIMARY HEALTH CARE, NUTRITION, AND WASH SERVICES FOR THE POPULATION AFFECTED BY CONFLICT AND DISPLACEMENT IN SOUTH AND EAST DARFUR

AMERICAN RESCUE PLAN ACT FUNDING FOR HEALTH CENTERS

THIS PROGRAM WILL CONTRIBUTE TO THE SUCCESSFUL REINTEGRATION OF SUDANESE REFUGEES AND IDPS TO THEIR ORIGINAL HOMES IN SOUTHERN SUDAN BY ENSURING THE

TAS::89 0328::TAS RECOVERY MEMPHIS LIGHT, GAS, AND WATER IMPLEMENTAION OF SMART GRID TECHNOLOGY IN A NETWORK ELECTRIC DISTRIBUTION SYSTEM

CAPITAL DEVELOPMENT

AMERICAN LIGHTWEIGHT MATERIALS MANUFACTURING INNOVATION INSTITUTE - ECOSYSTEM AND GROWTH

EXPANDING AND SCALING OPERATION NEXT: PREPARING MILITARY PERSONNEL FOR CAREERS IN ADVANCED MANUFACTURING

RYAN WHITE PART C OUTPATIENT EIS PROGRAM

HEAD START

LIFT - HYPERSONIC THERMAL MANAGEMENT RESEARCH (#5) - PROGRAM INCREASE

ALMMII - HYPERSONIC THERMAL MANAGEMENT RESEARCH

RAPID CLINICAL SURGE-TESTING FOR BIOTHREAT AGENTS

PROVIDES FUNDS TO INVEST IN INNOVATIVE LOCAL ACTIVITIES THAT IMPROVE LOW-INCOME COMMUNITIES

TAS::89 0331::TAS RECOVERY RECOVERY ACT: CUSHMAN NORTH FORK SKOKOMISH POWERHOUSE

CENTER OF EXCELLENCE FOR COMPREHENSIVE INTEGRATED HIV CARE

LIFT - HYPERSONIC MATERIALS ACCELERATION (#3) - PROGRAM INCREASE

LIFT - HYPERSONIC THERMAL MANAGEMENT RESEARCH (#4) - PROGRAM INCREASE

MISSION SYSTEMS INTEGRATOR CALL FOR THE JOINT MULTI-ROLE TECHNOLOGY DEMONSTRATOR MISSION SYSTEMS ARCHITECTURE DEMONSTRATION CAPSTONE DEMONSTRATION

CERTIFIED COMMUNITY BEHAVIORAL HEALTH CENTER EXPANSION FOR LOVE, CARTER, GARVIN, MURRAY, PONTOTOC, SEMINOLE, JOHNSTON, MARSHALL AND BRYAN COUNTIES

RAPID DETECTION OF PATHOGENS AND ANTIMICROBIAL SUSCEPTIBILITY DIRECTLY IN PATIENT SAMPLES

DUCTUS ARTERIOSUS STENT TO IMPROVE CONGENITAL HEART DEFECT MORTALITY - ABSTRACT THE TECHNICAL CHALLENGES FACED BY PEDIATRIC CARDIOVASCULAR PHYSICIANS (SURGEONS AND INTERVENTIONALISTS ALIKE) HAVE LONG BEEN IGNORED, FORCING THEM TO USE DEVICES DESIGNED FOR ADULTS AND DIFFERENT CONDITIONS TO TREAT AILING BABIES WITH VERY SPECIFIC ANATOMICAL CONSIDERATIONS. ONE SUCH CASE IS IN THE SUSTAINED OPENING OF THE DUCTUS ARTERIOSUS, A NATURAL CONDUIT THAT EXISTS IN ALL NEWBORNS BUT CLOSES SHORTLY AFTER BIRTH. IN CERTAIN CONGENITAL HEART DEFECTS, IT IS CRUCIAL TO MAINTAIN DUCTUS PATENCY FOR THE NEWBORN TO SURVIVE WITHOUT SURGICAL INTERVENTION. THERE IS NO DUCTUS ARTERIOSUS STENT COMMERCIALLY AVAILABLE IN THE US. PEDIATRIC INTERVENTIONAL CARDIOLOGISTS CURRENTLY REPURPOSE ADULT STENTS FOR THE DUCTUS, AND ALL-CAUSE DUCTUS REINTERVENTION IS 47%. THE ALTERNATIVE IS OPEN-CHEST SURGERY ON A NEONATE TO PLACE A SHUNT THAT CARRIES A 13.1% RISK OF MORBIDITY AND 7.2% RISK OF MORTALITY IN THE US. STARLIGHT CARDIOVASCULAR PROPOSES CREATING AND COMMERCIALIZING THE FIRST FDA-APPROVED DUCTUS ARTERIOSUS STENT THAT IS SPECIFICALLY DESIGNED TO ADDRESS THE CHALLENGES FACING TREATING PHYSICIANS, INCLUDING A RIGHT-SIZED DELIVERY SYSTEM, END-TO-END COVERAGE OF THE DUCTUS, NAVIGATION AND DEPLOYMENT THROUGH TORTUOUS DUCTUS ANATOMY, AND PRECISE PLACEMENT TO AVOID STENT PROTRUSION INTO THE AORTA AND PULMONARY ARTERIES. A STENT DESIGNED AND TESTED SPECIFICALLY FOR THIS PURPOSE HAS THE POTENTIAL TO DECREASE REINTERVENTIONS, MORBIDITY, AND POTENTIALLY MORTALITY FOR BABIES WITH DUCTAL-DEPENDENT CIRCULATION. THE FEASIBILITY OF THE INNOVATIVE STENT SYSTEM DESIGNED FOR PEDIATRIC APPLICATIONS USING SELF-EXPANDING TECHNOLOGY WAS DEMONSTRATED IN A SUCCESSFUL PHASE I THROUGH NUMEROUS ROUNDS OF BENCH TESTING, PHYSICIAN EVALUATIONS, AND AN ANIMAL STUDY; AND THIS PHASE II APPLICATION PROPOSES FINALIZING THE STENT DESIGN AND COMPLETING PRECLINICAL TESTING NECESSARY FOR A CLINICAL TRIAL AND FDA APPROVAL. THROUGH RAPID ITERATIONS, STARLIGHT WILL BEGIN BY OPTIMIZING THE STENT SYSTEM FOR DESIGN CHARACTERISTICS AND MANUFACTURABILITY. STARLIGHT WILL THEN COMPLETE A CHRONIC GLP ANIMAL STUDY IN 16 NEWBORN LAMBS TO DEMONSTRATE STENT PATENCY OVER 180 DAYS. VERIFICATION AND VALIDATION (V&V) TESTING OF ALL ASPECTS OF THE STENT SYSTEM (INCLUDING BIOCOMPATIBILITY, STERILIZATION, AND MECHANICAL TESTING) WILL THEN BE PERFORMED IN ACCORDANCE WITH FDA GUIDANCE DOCUMENTS FOR ENDOVASCULAR STENTS. THIS PHASE II PROJECT WILL RESULT IN A FINALIZED DUCTUS ARTERIOSUS STENT SYSTEM DESIGN THAT HAS PASSED ALL OF THE NECESSARY PRECLINICAL TESTING REQUIRED FOR A CLINICAL TRIAL AND SUBSEQUENT FDA APPROVAL THROUGH THE HUMANITARIAN DEVICE EXEMPTION PATHWAY.

HIGHLY PRODUCTIVE CELL-FREE BIOCONVERSION OF METHANE

LEAN DEMO

WORKFORCE DEVELOPMENT SUPPORT TO ORGANIC INDUSTRIAL BASE: DEVELOPING TALENT PIPELINES THROUGH CROSS MII SYNERGY TO SUPPORT THE IOWA ARMY AMMUNITION PLANT (IAAAP) AND AMERICAN ORDNANCE

LIGHTHOUSE CCBHC IMPROVEMENT AND ADVANCEMENT - THE LIGHTHOUSE CCBHC IMPROVEMENT AND ADVANCEMENT PROJECT WILL IMPROVE ACCESS TO COMMUNITY-BASED MENTAL HEALTH AND SUBSTANCE USE DISORDER TREATMENT AND SUPPORT AND EFFECTIVELY ADDRESS THE NEEDS OF PEOPLE WITH SED, SMI, AND COD ACROSS NINE COUNTIES IN RURAL SOUTH-CENTRAL OKLAHOMA. GRANT FUNDING WILL ESTABLISH A STRONG CRISIS CONTINUUM OF CARE TO TRANSITION CONSUMERS TO WHOLISTIC OUTPATIENT SERVICES AND EXPAND AND ENHANCE OUTPATIENT CHILDREN/YOUTH SERVICES. LIGHTHOUSE BEHAVIORAL WELLNESS CENTERS (LIGHTHOUSE), FORMERLY KNOWN AS MENTAL HEALTH SERVICES OF SOUTHERN OKLAHOMA, IS A CERTIFIED COMMUNITY BEHAVIORAL HEALTH CENTER (CCBHC). IT IS THE LARGEST PROVIDER OF ADDICTION AND MENTAL HEALTH SERVICES TO VULNERABLE INDIVIDUALS WITHIN A 5,000 SQUARE MILE SERVICE AREA, INCLUDING BRYAN, CARTER, GARVIN, JOHNSTON, LOVE, MARSHALL, MURRAY, PONTOTOC, AND SEMINOLE COUNTIES. LIGHTHOUSE, A NATIONAL HEALTH SERVICE CORP SITE, HAS BEEN PROVIDING CARE FOR OKLAHOMANS WITH SERIOUS MENTAL ILLNESS (SMI), SERIOUS EMOTIONAL DISTURBANCE (SED), SUBSTANCE USE DISORDER (SUD), AND CO-OCCURRING DISORDER (COD) SINCE 1955. WITH THIS PROJECT, LIGHTHOUSE WILL SERVE 3,291 UNDUPLICATED INDIVIDUALS OVER THE FOUR-YEAR PROJECT PERIOD. GOAL 1 OF THIS PROJECT IS TO IMPROVE ACCESS TO QUALITY, WHOLE-PERSON OUTPATIENT MENTAL HEALTH SERVICES FOR CHILDREN/YOUTH WITH UNMET MENTAL HEALTH NEEDS, ESPECIALLY THOSE WITH SED AND THEIR FAMILIES ACROSS THE SERVICE AREA. OBJECTIVES TO BE ACHIEVED INCLUDE ESTABLISHING AND IMPLEMENTING CHILDREN'S TEAMS ACROSS THE NINE-COUNTY AREA THROUGH LEVERAGED PARTNERSHIPS WITH LOCAL SCHOOLS. GOAL 2 OF THIS PROJECT IS TO IMPROVE THE CRISIS CONTINUUM OF CARE FOR CONSUMERS DISCHARGING FROM CRISIS OR URGENT RECOVERY SERVICES AND THOSE IDENTIFIED BY THE STATE AS "MOST IN NEED" OF BEHAVIORAL HEALTH SERVICES. OBJECTIVES TO BE ACHIEVED INCLUDE ESTABLISHING AND IMPLEMENTING COMMUNITY ENGAGEMENT AND OUTREACH TEAMS. GOAL 3 OF THIS PROJECT IS TO EXPAND OUTPATIENT PRIMARY CARE SCREENING, MONITORING, AND TREATMENT OF CHRONIC AND PREVENTIVE PHYSICAL HEALTH CARE SERVICES FOR CONSUMERS. OBJECTIVES TO BE ACHIEVED INCLUDE THE ADDITION OF A PRIMARY CARE PROVIDER AND NURSE CASE MANAGER. GOAL 4 FOR THIS PROJECT IS EFFECTIVE, EFFICIENT IMPLEMENTATION AND ADMINISTRATION OF THE PROJECT. OBJECTIVES INCLUDE TIMELY AND ACCURATE REPORTING, MEETING ALL REQUIRED ACTIVITIES; CONDUCTING COMMUNITY NEEDS ASSESSMENTS EVERY THREE YEARS; AND COLLECTING, REPORTING, AND TRACKING OUTCOMES AND QUALITATIVE DATA.

HUMANITARIAN ASSISTANCE

FOREIGN ASSISTANCE

HUMANITARIAN ASSISTANCE

THIS GRANT SUPPORTS ARC'S PROGRAM IN SOUTH DARFUR WHICH PROVIDES HUMANITARIAN SUPPORT.

PROVIDING ASSISTANCE & PROMOTING THE WELLBEING & SELF-RELIANCE OF CONGOLESE REFUGEES IN KIZIBA, GIHEMBE, NYABIHEKE, KIGEME & MUGOMBWA REFUGEE CAMPS

PERSONAL RESPONSIBILITY EDUCATION PROGRAM (PREP) INNOVATIVE STRATEGIES

PURPOSE: REHABILITATE RUNWAY. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT REHABILITATES 6,200 FEET OF RUNWAY 10/28 TO MAINTAIN THE STRUCTURAL INTEGRITY OF THE PAVEMENT AND TO MINIMIZE FOREIGN OBJECT DEBRIS. THIS PROJECT FUNDS THE FINAL PHASE, WHICH CONSISTS OF CONSTRUCTION OF 6,200 FEET OF THE RUNWAY. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH KIMBALL, NEBRASKA.

ALMMII - HYPERSONICS THERMAL MANAGEMENT RESEARCH - PHASE 2

INCLUDE STANDARD PROVISION-HOMELAND SECURITY

CARLOS PAGAN CCBHC - PROMESA, INC., A NEW YORK STATE (NYS)-DESIGNATED CCBHC (BRONX), ENDEAVORS TO SERVICE INDIVIDUALS WITH SERIOUS MENTAL ILLNESS (SMI) OR SEVERE SUBSTANCE USE DISORDER (SUD), CHILDREN AND ADOLESCENTS WITH SERIOUS EMOTIONAL DISTURBANCE (SED), AND THOSE WITH CO-OCCURRING MENTAL, SUBSTANCE USE, AND/OR PHYSICAL HEALTH DISORDERS, OR EXPERIENCING A SMI OR SUD-RELATED CRISIS IN THE KINGS COUNTY (BROOKLYN), NEW YORK CITY (NYC) SERVICE AREA THROUGH THE SAMSHA CCBHC - PLANNING, DEVELOPMENT, AND IMPLEMENTATION GRANT OPPORTUNITY. AS A LEADER WITHIN THE MENTAL HEALTH AND SUBSTANCE PROVIDER SPACE IN NYC, AND AS AN AFFILIATE OF THE ACACIA NETWORK, PROMESA HAS MADE STRIDES IN CONTENDING AGAINST THE INCREASED PREVALENCE OF MENTAL HEALTH AND SUBSTANCE USE DISORDERS, PARTICULARLY IN BROOKLYN, NY. BROOKLYN IS HOME TO 2,576,771 RESIDENTS, AND 63.6% OF THE POPULATION IDENTIFY AS PEOPLE OF COLOR (POC). 35.6% OF BROOKLYN RESIDENTS ARE FOREIGN BORN AND NEARLY HALF OF ITS POPULATION SPEAKS A LANGUAGE OTHER THAN ENGLISH (44.5%), WHICH CAN BE A BARRIER TO ACCESSING TREATMENT (14.2% OF BROOKLYN RESIDENTS HAVE LIMITED ENGLISH ABILITY). CONSIDERING THESE BARRIERS AND MORE, THERE IS A HIGH PREVALENCE OF SUBSTANCE USE AND MENTAL HEALTH CONDITIONS AMONG THE TARGET POPULATION AND OFTEN THESE CONDITIONS GO UNDIAGNOSED AND UNTREATED. THROUGH THIS FUNDING, PROMESA WILL 1) HIRE ADDITIONAL LEADERSHIP, CLINICAL, AND SUPPORTIVE SERVICES STAFF TO EXPAND ACCESS; 2) IMPLEMENT COMPREHENSIVE ASSESSMENT UTILIZING VALIDATED SCREENING AND ASSESSMENT TOOLS, INCLUSIVE OF THOSE FOR ADVERSE CHILDHOOD EXPERIENCES (ACES), SUICIDE RISK, AND BEHAVIORAL HEALTH DISORDERS, AS INDICATED; 3) DEVELOP TAILORED SERVICE AND TREATMENT PLANS; AND 4) INTRODUCE CRISIS AND PSYCHIATRIC REHABILITATION SERVICES; 5) PROVIDE A RANGE OF EVIDENCE-BASED PREVENTION AND TREATMENT SERVICES THAT ADDRESS A COMBINATION OF IMMEDIATE AND LONG-TERM NEEDS. PROMESA WILL CONTINUE TO PROVIDE DIRECT OUTPATIENT MENTAL HEALTH AND SUBSTANCE USE TREATMENT SERVICES, LEVERAGING ITS CURRENT PROGRAMS AND COMMUNITY PARTNERSHIPS TO RECRUIT CONSUMERS; AND COMMIT TO DEVELOPING FURTHER LINKAGES WITH ENTITIES SUCH AS THE VETERAN ADMINISTRATION AND OTHER PRIMARY HEALTH CARE AND BEHAVIORAL HEALTH CARE ORGANIZATIONS IN CLOSE PROXIMITY TO PROMESA'S CARLOS PAGAN HEALTH CENTER. OVER THE FOUR-YEAR PROGRAM, PROMESA WILL ACHIEVE THE FOLLOWING: - HIRE AN ADDITIONAL 9.0 FTE STAFF TO INCREASE AVAILABILITY, ACCESS TO, AND COORDINATION OF INTEGRATED, EVIDENCE-BASED MENTAL HEALTH AND SUBSTANCE USE CARE, INCLUDING CRISIS AND PSYCHIATRIC REHABILITATION SERVICES, AT THE CLINIC AND THROUGH THE MOBILE UNIT. - 100% OF CLINICAL STAFF WILL HAVE EARNED THEIR CERTIFICATE IN INTEGRATED MENTAL HEALTH AND ADDICTIONS TREATMENT TRAINING (IMHATT). - INCREASE INITIATION AND ENGAGEMENT IN TREATMENT BY 25% AMONG ENROLLED CLIENTS (FROM BASELINE). - REDUCE THE TIME BETWEEN SCREENING AND TREATMENT INITIATION AMONG ENROLLED CLIENTS BY 25% (FROM BASELINE). - COMPLETE A COMPREHENSIVE INTAKE AND INTEGRATED TREATMENT PLAN DEVELOPMENT PROCESS WITH 100% OF CONSUMERS SERVED. - INCREASE THE NUMBER OF CONSUMERS INITIATED ON MEDICATION-ASSISTED TREATMENT (MAT) BY 20% (FROM BASELINE). - REDUCE SYMPTOMS OF ANXIETY AND/OR DEPRESSION AMONG ENROLLED CLIENTS BY 15% (FROM BASELINE). THE PROGRAM WILL ENROLL 150 CONSUMERS IN EACH PROGRAM YEAR (YEARS 1 - 4), FOR A TOTAL OF 600 CONSUMERS OVER THE LIFE OF THE PROGRAM.

COMPREHENSIVE HEALTH, NUTRITION AND PROTECTION PROGRAM FOR CONGOLESE AND BURUNDIAN REFUGEES HOSTED IN RWANDA

TO PROVIDE IMPROVED ACCESS TO LIFE SAVING AND EMPOWERMENT SERVICES TO VULNERABLE GROUPS AMONG IDPS, RETURNEES, AND HOST COMMUNITIES THROUGH INTEGRATED AND COMPREHENSIVE RESPONSE IN SOUTH SUDAN.

TO IMPROVE WELL-BEING AND RESILIENCE OF REFUGEES AND COMMUNITIES VIA PROVISION OF GBV, SL, CWC/AAP, MHPSS, CP, AND WASH IN UGANDA

LIVELIHOOD, ECONOMIC, ACCOUNTABLE AND PROTECTIVE SOLUTIONS II (LEAPS2) FOR REFUGEES AND HOST COMMUNITIES

LIVELIHOOD, ECONOMIC, ACCOUNTABLE AND PROTECTIVE SOLUTIONS II (LEAPS2) FOR REFUGEES AND HOST COMMUNITIES

AMERICAN RESCUE PLAN ACT FUNDING FOR HEALTH CENTERS

DEVELOPMENT OF A PEANUT ALLERGY TREATMENT FOR ADULTS USING MICRONEEDLES

TO IMPROVE THE WELL-BEING AND SELF-RELIANCE OF REFUGEES IN RWANDA THROUGH THE PROVISION OF HEALTHCARE, NUTRITION AND GBV PREVENTION AND RESPONSE.

LIVELIHOOD, ECONOMIC, ACCOUNTABLE AND PROTECTIVE SOLUTIONS (LEAPS) TO IMPROVE THE WELL-BEING AND RESILIENCE OF REFUGEES AND HOST COMMUNITIES IN UGANDA.

TAS::89 0328::TAS RECOVERY WISCONSIN POWER AND LIGHT COMPANY (WPL) WILL IMPLEMENTING A POWER FACTOR MANAGEMENT SYSTEM IN ITS WISCONSIN TERRITORY.

TO PROVIDE AIDS/HIV SERVICES

COMPREHENSIVE HEALTH, NUTRITION AND PROTECTION PROGRAM FOR CONGOLESE AND BURUNDIAN REFUGEES HOSTED IN RWANDA

PRIMARY HEALTH CARE, MICRO-ENTERPRISE DEVELOPMENT, WASH & GBV CAPACITY STRENGTHENING FOR BURMESE & ETHNIC MINORITY REFUGEES ON THE THAI-BURMA BORDER

IMPROVE WELL-BEING AND RESILIENCE THROUGH A MULTI-SECTORAL APPROACH

IMPROVE WELL-BEING AND SELF-RELIANCE OF CONGOLESE AND BURUNDIAN REFUGEES THROUGH INTEGRATED SECTOR PROVISIONS AND RESPONSE

COMPREHENSIVE HEALTH, NUTRITION AND PROTECTION PROGRAM FOR CONGOLESE AND BURUNDIAN REFUGEES HOSTED IN RWANDA

ESTABLISHMENT OF A SUSTAINABLE SOCIAL ENTERPRISE APPROACH IN SOUTH KIVU, DRC

HIGH ENERGY COST GRANT

HIGH ENERGY COST GRANT

REVOLUTIONIZING ORE TO STEEL TO IMPACT EMISSIONS (ROSIE) SBIR/STTR TO OBTAIN A COPY OF THE FUNDING OPPORTUNITY ANNOUNCEMENT (FOA) PLEASE GO TO THE ARPA-E WEBSITE AT HTTPS://ARPA-E-FOA.ENERGY.GOV. TO APPLY TO THIS FOA, APPLICANTS MUST REGISTER WITH AND SUBMIT APPLICATION MATERIALS THROUGH ARPA-E EXCHANGE (HTTPS://ARPA-E-FOA.ENERGY.GOV/REGISTRATION.ASPX). FOR DETAILED GUIDANCE ON USING ARPA-E EXCHANGE, PLEASE REFER TO THE ARPA-E EXCHANGE USER GUIDE (HTTPS://ARPA-E-FOA.ENERGY.GOV/MANUALS.ASPX). ARPA-E WILL NOT REVIEW OR CONSIDER CONCEPT PAPERS SUBMITTED THROUGH OTHER MEANS. FOR PROBLEMS WITH ARPA-E EXCHANGE, EMAIL EXCHANGEHELP@HQ.DOE.GOV (WITH FOA NAME AND NUMBER IN THE SUBJECT LINE). QUESTIONS ABOUT THIS FOA? CHECK THE FREQUENTLY ASKED QUESTIONS AVAILABLE AT HTTP://ARPA-E.ENERGY.GOV/FAQ. FOR QUESTIONS THAT HAVE NOT ALREADY BEEN ANSWERED, EMAIL ARPA-E-CO@HQ.DOE.GOV. AGENCY OVERVIEW THE ADVANCED RESEARCH PROJECTS AGENCY – ENERGY (ARPA-E), AN ORGANIZATION WITHIN THE DEPARTMENT OF ENERGY (DOE), IS CHARTERED BY CONGRESS IN THE AMERICA COMPETES ACT OF 2007 (P.L. 110-69), AS AMENDED BY THE AMERICA COMPETES REAUTHORIZATION ACT OF 2010 (P.L. 111-358), AS FURTHER AMENDED BY THE ENERGY ACT OF 2020 (P.L. 116-260): “(A) TO ENHANCE THE ECONOMIC AND ENERGY SECURITY OF THE UNITED STATES THROUGH THE DEVELOPMENT OF ENERGY TECHNOLOGIES THAT— (I) REDUCE IMPORTS OF ENERGY FROM FOREIGN SOURCES; (II) REDUCE ENERGY-RELATED EMISSIONS, INCLUDING GREENHOUSE GASES; (III) IMPROVE THE ENERGY EFFICIENCY OF ALL ECONOMIC SECTORS; (IV) PROVIDE TRANSFORMATIVE SOLUTIONS TO IMPROVE THE MANAGEMENT, CLEAN-UP, AND DISPOSAL OF RADIOACTIVE WASTE AND SPENT NUCLEAR FUEL; AND (V) IMPROVE THE RESILIENCE, RELIABILITY, AND SECURITY OF INFRASTRUCTURE TO PRODUCE, DELIVER, AND STORE ENERGY; AND (B) TO ENSURE THAT THE UNITED STATES MAINTAINS A TECHNOLOGICAL LEAD IN DEVELOPING AND DEPLOYING ADVANCED ENERGY TECHNOLOGIES.” ARPA-E ISSUES THIS FUNDING OPPORTUNITY ANNOUNCEMENT (FOA) UNDER ITS AUTHORIZING STATUTE CODIFIED AT 42 U.S.C. § 16538. THE FOA AND ANY COOPERATIVE AGREEMENTS OR GRANTS MADE UNDER THIS FOA ARE SUBJECT TO 2 C.F.R. PART 200 AS SUPPLEMENTED BY 2 C.F.R. PART 910. ARPA-E FUNDS RESEARCH ON, AND THE DEVELOPMENT OF, TRANSFORMATIVE SCIENCE AND TECHNOLOGY SOLUTIONS TO ADDRESS THE ENERGY AND ENVIRONMENTAL MISSIONS OF THE DEPARTMENT. THE AGENCY FOCUSES ON TECHNOLOGIES THAT CAN BE MEANINGFULLY ADVANCED WITH A MODEST INVESTMENT OVER A DEFINED PERIOD OF TIME IN ORDER TO CATALYZE THE TRANSLATION FROM SCIENTIFIC DISCOVERY TO EARLY-STAGE TECHNOLOGY. FOR THE LATEST NEWS AND INFORMATION ABOUT ARPA-E, ITS PROGRAMS AND THE RESEARCH PROJECTS CURRENTLY SUPPORTED, SEE: HTTP://ARPA-E.ENERGY.GOV/. ARPA-E FUNDS TRANSFORMATIONAL RESEARCH. EXISTING ENERGY TECHNOLOGIES GENERALLY PROGRESS ON ESTABLISHED “LEARNING CURVES” WHERE REFINEMENTS TO A TECHNOLOGY AND THE ECONOMIES OF SCALE THAT ACCRUE AS MANUFACTURING AND DISTRIBUTION DEVELOP DRIVE IMPROVEMENTS TO THE COST/PERFORMANCE METRIC IN A GRADUAL FASHION. THIS CONTINUAL IMPROVEMENT OF A TECHNOLOGY IS IMPORTANT TO ITS INCREASED COMMERCIAL DEPLOYMENT AND IS APPROPRIATELY THE FOCUS OF THE PRIVATE SECTOR OR THE APPLIED TECHNOLOGY OFFICES WITHIN DOE. IN CONTRAST, ARPA-E SUPPORTS TRANSFORMATIVE RESEARCH THAT HAS THE POTENTIAL TO CREATE FUNDAMENTALLY NEW LEARNING CURVES. ARPA-E TECHNOLOGY PROJECTS TYPICALLY START WITH COST/PERFORMANCE ESTIMATES WELL ABOVE THE LEVEL OF AN INCUMBENT TECHNOLOGY. GIVEN THE HIGH RISK INHERENT IN THESE PROJECTS, MANY WILL FAIL TO PROGRESS, BUT SOME MAY SUCCEED IN GENERATING A NEW LEARNING CURVE WITH A PROJECTED COST/PERFORMANCE METRIC THAT IS SIGNIFICANTLY BETTER THAN THAT OF THE INCUMBENT TECHNOLOGY. ARPA-E FUNDS TECHNOLOGY WITH THE POTENTIAL TO BE DISRUPTIVE IN THE MARKETPLACE. THE MERE CREATION OF A NEW LEARNING CURVE DOES NOT ENSURE MARKET PENETRATION. RATHER, THE ULTIMATE VALUE OF A TECHNOLOGY IS DETERMINED BY THE MARKETPLACE, AND IMPACTFUL TECHNOLOGIES ULTIMATELY BECOME DISRUPTIVE – THAT IS, THEY ARE WIDELY ADOPTED AND DISPLACE EXISTING TECHNOLOGIES FROM THE MARKETPLACE OR CREATE ENTIRELY NEW MARKETS. ARPA-E UNDERSTANDS THAT DEFINITIVE PROOF OF MARKET DISRUPTION TAKES TIME, PARTICULARLY FOR ENERGY TECHNOLOGIES. THEREFORE, ARPA-E FUNDS THE DEVELOPMENT OF TECHNOLOGIES THAT, IF TECHNICALLY SUCCESSFUL, HAVE CLEAR DISRUPTIVE POTENTIAL, E.G., BY DEMONSTRATING CAPABILITY FOR MANUFACTURING AT COMPETITIVE COST AND DEPLOYMENT AT SCALE. ARPA-E FUNDS APPLIED RESEARCH AND DEVELOPMENT. THE OFFICE OF MANAGEMENT AND BUDGET DEFINES “APPLIED RESEARCH” AS AN “ORIGINAL INVESTIGATION UNDERTAKEN IN ORDER TO ACQUIRE NEW KNOWLEDGE…DIRECTED PRIMARILY TOWARDS A SPECIFIC PRACTICAL AIM OR OBJECTIVE” AND DEFINES “EXPERIMENTAL DEVELOPMENT” AS “CREATIVE AND SYSTEMATIC WORK, DRAWING ON KNOWLEDGE GAINED FROM RESEARCH AND PRACTICAL EXPERIENCE, WHICH IS DIRECTED AT PRODUCING NEW PRODUCTS OR PROCESSES OR IMPROVING EXISTING PRODUCTS OR PROCESSES.”1 APPLICANTS INTERESTED IN RECEIVING FINANCIAL ASSISTANCE FOR BASIC RESEARCH (DEFINED BY THE OFFICE OF MANAGEMENT AND BUDGET AS “EXPERIMENTAL OR THEORETICAL WORK UNDERTAKEN PRIMARILY TO ACQUIRE NEW KNOWLEDGE OF THE UNDERLYING FOUNDATIONS OF PHENOMENA AND OBSERVABLE FACTS”)2 SHOULD CONTACT THE DOE’S OFFICE OF SCIENCE (HTTP://SCIENCE.ENERGY.GOV/). OFFICE OF SCIENCE NATIONAL SCIENTIFIC USER FACILITIES (HTTP://SCIENCE.ENERGY.GOV/USER-FACILITIES/) ARE OPEN TO ALL RESEARCHERS, INCLUDING ARPA-E APPLICANTS AND AWARDEES. THESE FACILITIES PROVIDE ADVANCED TOOLS OF MODERN SCIENCE INCLUDING ACCELERATORS, COLLIDERS, SUPERCOMPUTERS, LIGHT SOURCES AND NEUTRON SOURCES, AS WELL AS FACILITIES FOR STUDYING THE NANOWORLD, THE ENVIRONMENT, AND THE ATMOSPHERE. PROJECTS FOCUSED ON EARLY-STAGE R&D FOR THE IMPROVEMENT OF TECHNOLOGY ALONG DEFINED ROADMAPS MAY BE MORE APPROPRIATE FOR SUPPORT THROUGH THE DOE APPLIED ENERGY OFFICES INCLUDING: THE OFFICE OF ENERGY EFFICIENCY AND RENEWABLE ENERGY (HTTP://WWW.EERE.ENERGY.GOV/), THE OFFICE OF FOSSIL ENERGY AND CARBON MANAGEMENT (HTTPS://WWW.ENERGY.GOV/FECM/OFFICE-FOSSIL-ENERGY-AND-CARBON-MANAGEMENT), THE OFFICE OF NUCLEAR ENERGY (HTTP://WWW.ENERGY.GOV/NE/OFFICE-NUCLEAR-ENERGY), AND THE OFFICE OF ELECTRICITY (HTTPS://WWW.ENERGY.GOV/OE/OFFICE-ELECTRICITY). SBIR/STTR PROGRAM OVERVIEW THE SMALL BUSINESS INNOVATION RESEARCH (SBIR) AND SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAMS ARE GOVERNMENT-WIDE PROGRAMS AUTHORIZED UNDER SECTION 9 OF THE SMALL BUSINESS ACT (15 U.S.C. § 638). THE OBJECTIVES OF THE SBIR PROGRAM ARE TO (1) STIMULATE TECHNOLOGICAL INNOVATION IN THE PRIVATE SECTOR, (2) STRENGTHEN THE ROLE OF SMALL BUSINESS CONCERNS IN MEETING FEDERAL R&D NEEDS, (3) INCREASE PRIVATE SECTOR COMMERCIALIZATION OF INNOVATIONS DERIVED FROM FEDERAL R&D ACTIVITIES, (4) FOSTER AND ENCOURAGE PARTICIPATION BY SOCIALLY AND ECONOMICALLY DISADVANTAGED AND WOMEN-OWNED SMALL BUSINESS CONCERNS, AND (5) IMPROVE THE RETURN ON INVESTMENT FROM FEDERALLY FUNDED RESEARCH AND ECONOMIC BENEFITS TO THE NATION. THE OBJECTIVE OF THE STTR PROGRAM IS TO STIMULATE COOPERATIVE PARTNERSHIPS OF IDEAS AND TECHNOLOGIES BETWEEN SMALL BUSINESS CONCERNS AND PARTNERING RESEARCH INSTITUTIONS THROUGH FEDERALLY FUNDED R&D ACTIVITIES.3 ARPA-E ADMINISTERS A JOINT SBIR/STTR PROGRAM IN ACCORDANCE WITH THE SMALL BUSINESS ACT AND THE SBIR AND STTR POLICY DIRECTIVE ISSUED BY THE U.S. SMALL BUSINESS ADMINISTRATION (SBA).4 ARPA-E PROVIDES SBIR/STTR FUNDING IN THREE PHASES (PHASE I, PHASE II, AND PHASE IIS). PROGRAM OVERVIEW THE ROSIE (REVOLUTIONIZING ORE TO STEEL TO IMPACT EMISSIONS) PROGRAM IS A 3-YEAR, $35 MILLION PROGRAM DEVELOPING PATHWAYS TO ZERO EMISSIONS IRONMAKING AND ULTRA-LOW LIFE CYCLE EMISSIONS FOR STEELMAKING. THE PROGRAM SEEKS TO FUND THE DEVELOPMENT AND DEMONSTRATION OF NOVEL TECHNOLOGIES THAT PRODUCE IRON-BASED PRODUCTS FROM IRON-CONTAINING ORES AND ALTERNATIVE FEEDSTOCKS WITHOUT PROCESS EMISSIONS IN THE IRONMAKING STEP. THE PROGRAM’S TECHNOLOGIES WILL DEMONSTRATE A PATH TO COST-COMPETITIVENESS WITH TRADITIONAL INCUMBENT CARBOTHERMIC BLAST FURNACE IRONMAKING. THE TECHNOLOGIES FUNDED THROUGH THIS PROGRAM HAVE TRANSFORMATIVE POTENTIAL, BECAUSE NO TECHNOLOGY ROUTE EXISTS TODAY THAT MEETS BOTH THIS EMISSIONS CONSTRAINT AND THIS COST PARITY GOAL. THE PROGRAM WILL HAVE TWO CATEGORIES. CATEGORY A INCLUDES PROCESSES FROM ORE TO IRONMAKING. CATEGORY B MUST INCLUDE IRONMAKING BUT CAN EXTEND TO DOWNSTREAM STEEL PRODUCTION. TECHNOLOGIES MUST HAVE THE POTENTIAL TO ACHIEVE: • ZERO NON-BIOGENIC5 GREENHOUSE GAS (GHG) EMISSIONS SPECIFICALLY FROM THE IRONMAKING6 PROCESS. • ULTRA-LOW CRADLE-TO-GATE LIFECYCLE GHG EMISSIONS EMITTED PER TONNE OF IRON OR STEEL PRODUCT (<0.7 TONNES CO2 EMITTED PER TONNE OF HRC STEEL) • PROCESS AND PRODUCT SCALABILITY OF >15 MILLION TONNES • COST PARITY WITH THE IRON OR STEEL PRODUCT BEING DISPLACED • MATERIALS PROPERTIES CONSISTENT WITH RELEVANT COMMERCIAL PRODUCT BEING DISPLACED • PRODUCED 10 KILOGRAMS (KG) OF PROPOSED PRODUCT BY PROJECT END • A DEMONSTRATED PRODUCTION RATE OF 1 KG/HOUR BY PROJECT END IF SUCCESSFUL, NOVEL IRONMAKING TECHNOLOGIES MEETING THE METRICS SET FORTH BY THE PROGRAM WILL ENABLE A REDUCTION OF U.S. EMISSIONS BY OVER 65 MILLION TONNES (MT) CARBON DIOXIDE EMITTED (CO2E) ANNUALLY (~1% OF U.S. EMISSIONS) AND GLOBAL EMISSIONS BY OVER 2.9 GIGATONNES (GT) ANNUALLY (5.5 % OF GLOBAL EMISSIONS).

RAPID SENSITIVE LOW-COST TEST FOR RESISTANT MICROBES CAUSING HOSPITAL INFECTIONS

LIVELIHOOD, ECONOMIC, ACCOUNTABLE AND PROTECTIVE SOLUTIONS (LEAPS) FOR REFUGEES AND HOST COMMUNITIES

CAMINO NUEVO CCBHC - PROMESA, INC. IS SEEKING SUPPORT FOR THE ESTABLISHMENT OF A NEW CCBHC AT ITS CAMINO NUEVO FACILITY AT 175 CENTRAL AVENUE, ALBANY, NY 12206. THE CCBHC WILL PROVIDE COMPREHENSIVE, COORDINATED BEHAVIORAL HEALTHCARE TO THOSE WITH SERIOUS MENTAL ILLNESS (SMI) AND/OR SUBSTANCE USE DISORDER (SUD), CHILDREN WITH SERIOUS EMOTIONAL DISTURBANCE, AND THOSE EXPERIENCING AN SMI- OR SUD-RELATED CRISIS IN THE ALBANY REGION OF NEW YORK STATE (NYS). THE SERVICE AREA IS PREDOMINANTLY WHITE (81%), 43% OF RENTER HOUSEHOLDS ARE RENT-BURDENED (SPENDING 30% OR MORE OF INCOME ON RENT), AND MEDIAN HOUSEHOLD INCOME IN THE SERVICE AREA IS LOWER THAN THAT OF NYS AS A WHOLE. EIGHT OF THE 12 COUNTIES IN THE SERVICE AREA ARE HPSAS FOR PRIMARY CARE, SIX ARE HPSAS FOR MENTAL HEALTHCARE, AND FIVE ARE HPSAS FOR DENTAL CARE. PROMESA'S CAMINO NUEVO SITE CURRENTLY OPERATES A NYS-LICENSED INTEGRATED OUTPATIENT SERVICES (IOS) PROGRAM THAT PROVIDES SUBSTANCE USE TREATMENT, INCLUDING MEDICATION ASSISTED TREATMENT (MAT) SUCH AS METHADONE, BUPRENORPHINE, AND NALTREXONE; MENTAL HEALTH SERVICES; AND BEGINNING AUGUST 2022 WILL OPERATE A MOBILE MEDICATION UNIT EQUIPPED TO DISPENSE MAT. WHILE THE SITE CURRENTLY OFFERS ROBUST SUBSTANCE USE SERVICES, PROMESA WILL USE CCBHC FUNDING TO ADD 8.25 FTE STAFF TO EXPAND AND BOLSTER ITS MENTAL HEALTH SERVICES.THIS INCLUDES 1.0 FTE PROGRAM DIRECTOR, 1.0 FTE INTAKE COORDINATOR, 0.75 FTE RN, 2.0 FTE CASE MANAGERS, 1.0 FTE COUNSELOR (LMSW), 1.0 FTE PSYCHIATRIC REHABILITATION WORKER, 1.0 FTE PEER, AND 0.5 FTE PSYCHIATRIST. IN ADDITION, FUNDING WILL BE USED FOR 0.5 FTE SENIOR ADMINISTRATOR/PROJECT DIRECTOR, 0.25 FTE TALENT DEVELOPMENT SPECIALIST (FOR TRAININGS), 0.5 FTE DIRECTOR OF CONTINUOUS QUALITY IMPROVEMENT/EVALUATOR, AND 0.5 FTE DATA ANALYST. WHEN COMBINED WITH CAMINO NUEVO'S EXISTING STAFF, THE CCBHC WILL HAVE A TOTAL OF 37.75 FTE STAFF. WITH THESE NEW HIRES, PROMESA WILL BE ABLE TO IMMEDIATELY IMPLEMENT SEVEN OF THE NINE CORE CCBHC SERVICES, INCLUDING THE DIRECT PROVISION OF SCREENING, ASSESSMENT, AND DIAGNOSIS, INCLUDING RISK ASSESSMENT; PATIENT- AND FAMILY-CENTERED TREATMENT PLANNING; OUTPATIENT MENTAL HEALTH AND SUBSTANCE USE SERVICES; PRIMARY CARE SERVICES AND MONITORING OF KEY HEALTH INDICATORS AND HEALTH RISK; TARGETED CASE MANAGEMENT; PEER SUPPORT, COUNSELOR SERVICES, AND FAMILY SUPPORTS; AND MENTAL HEALTHCARE FOR MILITARY PERSONNEL. WITHIN THE FIRST SIX MONTHS OF THE PROGRAM, CAMINO NUEVO WILL ADD CRISIS MANAGEMENT SERVICES AND PSYCHIATRIC REHABILITATION SERVICES TO ITS OFFERINGS. IN ORDER TO ACCOMPLISH THIS GOAL, THE FACILITY WILL EXECUTE A CONTRACT WITH PROMESA'S EXISTING CRISIS CALL CENTER, WHICH PROVIDES A CENTRALIZED NUMBER FOR SERVICE AREA RESIDENTS AND CCBHC CONSUMERS TO CALL AFTER HOURS. CRISIS COUNSELORS TRIAGE THE CALLS. IF DE-ESCALATION OVER THE PHONE CANNOT OCCUR, A MEMBER OF CAMINO NUEVO'S CRISIS TEAM WILL BE DISPATCHED TO ENGAGE THE CLIENT WITHIN 3 HOURS.PSYCHIATRIC REHABILITATION SERVICES WILL ALSO BE ESTABLISHED AT THE CLINIC THROUGH HIRING AND TRAINING A PSYCHIATRIC REHABILITATION WORKER TO PROVIDE MEDICATION EDUCATION, SELF-MANAGEMENT, COMMUNITY INTEGRATION SERVICES, ETC. IN ORDER TO MOST EFFECTIVELY SERVE CAMINO NUEVO'S CLIENTS, PROMESA WILL IMPLEMENT SEVERAL EVIDENCE-BASED PRACTICES, INCLUDING THE INTEGRATED TREATMENT FOR CO-OCCURRING DISORDERS TRAINING (AND SUBSEQUENTLY EARNING THE INTEGRATED MENTAL HEALTH AND ADDICTIONS TREATMENT CERTIFICATE), MOTIVATIONAL INTERVIEWING (MI), TRAUMA-INFORMED CARE (TIC), PEER & FAMILY SUPPORT SPECIALISTS, MAT, COGNITIVE BEHAVIORAL THERAPY (CBT), DIALECTICAL BEHAVIORAL THERAPY (DBT), SEEKING SAFETY, AND STAGES OF CARE. PROMESA AIMS TO SERVE 150 UNDUPLICATED INDIVIDUALS PER YEAR, FOR A TOTAL OF 600 THROUGHOUT THE LIFETIME OF THE PROJECT.

HIV CARE AND TREATMENT INTEGRATED PROGRAMS FOR COMPREHENSIVE CARE IN THE REPUBLIC

RAPID ANTIMICROBIAL SUSCEPTIBILITY TESTING DIRECTLY FROM URINE SPECIMENS - RAPID ANTIMICROBIAL SUSCEPTIBILITY TESTING DIRECTLY FROM PATIENT SPECIMENS ABSTRACT EACH YEAR, 20 MILLION PATIENTS ARE DIAGNOSED WITH INFECTIONS LEADING TO OVER 100,000 DEATHS AND COSTING THE US HEALTHCARE SYSTEM ABOUT $70B. ANTIBIOTIC RESISTANT INFECTIONS ARE INCREASINGLY COMMON, CAUSING ABOUT 3 MILLION INFECTIONS AND 35,000 DEATHS ANNUALLY IN THE US. PATIENTS, EVEN THOSE WITH LIFE-THREATENING INFECTIONS, CAN BE QUICKLY CURED IF, NEAR THE ONSET OF INFECTION, THEY CAN BE TREATED WITH AN ANTIBIOTIC THAT SPECIFICALLY TARGETS THE PATHOGEN CAUSING THE INFECTION. UNFORTUNATELY, TODAY’S DIAGNOSTIC METHODS REQUIRE 2-4 DAYS TO DETERMINE TAR- GETED, OR DEFINITIVE, THERAPIES. FOR THIS REASON, PHYSICIANS MUST TREAT PATIENTS EMPIRICALLY USING BROAD-SPECTRUM ANTIBIOTICS THAT ARE OFTEN LESS EFFECTIVE THAN DEFINITIVE TREATMENTS AND SOMETIMES EVEN COMPLETELY INEFFECTIVE. FURTHERMORE, TREATMENT WITH THESE POWERFUL DRUGS CAUSES THE SPREAD OF ANTIBIOTIC RESISTANCE. THIS IS EXACERBATED BY THE FACT THAT AT LEAST 30% OF ANTIBIOTICS ARE PRESCRIBED UNNECESSARILY TO PATIENTS THAT ARE IN FACT UNINFECTED. CURRENT ANTIMICROBIAL SUSCEPTIBILITY TESTING METHODS FOR DETERMINING THE DEFINITIVE THERAPIES TAKE DAYS TO DELIVER RESULTS BECAUSE THEY REQUIRE MULTIPLE LENGTHY STEPS INCLUDING A DAY-LONG STEP TO PURIFY THE PATHOGEN CELLS IN LARGE NUMBERS BY MICROBIOLOGICAL CULTURE. THIS PROPOSAL DEVELOPS NOVEL PRODUCTS THAT DETECT WHETHER PATIENTS ARE IN- FECTED, IDENTIFY THE PATHOGEN IN 30 MINUTES, AND DETERMINE THE DEFINITIVE TREATMENT IN JUST A FEW HOURS RATHER THAN THE DAYS REQUIRED TODAY. THE PROPOSED TESTS THUS HAVE THE POTENTIAL TO DRAMATICALLY IMPROVE PATIENT OUT- COMES AND ATTENUATE THE SPREAD OF RESISTANCE. THE NEW TESTS IDENTIFY (ID) PATHOGENS AND PERFORM ANTIMICROBIAL SUSCEPTIBILITY TESTING (AST) DIRECTLY FROM PATIENT SPECIMENS, ELIMINATING THE LENGTHY CULTURE STEPS REQUIRED BY THE CURRENT METHODS. THE NOVEL MULTIPATH TECHNOLOGY UNDERLYING THE TESTS USES INEXPENSIVE DIGITAL IMAGING TO RAPIDLY, SENSITIVELY, AND AFFORDABLY COUNT INDIVIDUAL MICROSCOPIC BACTERIAL CELLS WITHOUT MAGNIFICATION. THE MULTIPATH AST TESTS CAN DETERMINE THE DEFINITIVE TREATMENT FOR A MUCH BROADER RANGE OF INFECTIONS THAN OTHER EMERGING RAPID SUSCEPTIBILITY METHODS BECAUSE THEY CAN DETERMINE ANTIMICROBIAL SUSCEPTIBILITY FOR SPECIMENS WITH COMMENSAL BACTERIA AND FROM PATIENTS WITH POLYMICROBIAL INFECTIONS. THE EASY-TO-USE TESTS RUN ON THE AUTOMATED RANDOM- ACCESS MULTIPATH ANALYZER THAT IS CURRENTLY UNDER REGULATORY REVIEW. THIS PHASE II PROPOSAL DEVELOPS RAPID ID AND AST TESTS FOR URINARY TRACT INFECTIONS (UTIS). UTIS ACCOUNT FOR ABOUT HALF OF ALL INFECTIONS WHICH ARE INCREASINGLY CAUSED BY RESISTANT PATHOGENS. THE PROPOSED WORK BUILDS ON WORK PRESENTED IN THE PRELIMINARY RESULTS DEMON- STRATING THE FEASIBILITY OF AST DIRECTLY FROM URINE SPECIMENS. SPECIFICALLY, WE WILL (1) COMPLETE UTI ID/AST PRODUCT DEVELOPMENT; (2) COMPLETE ALPHA UTI/AST ANALYTICAL AND PRECLINICAL STUDIES; AND (3) COMPLETE EXTERNAL BETA PRE- CLINICAL STUDIES AND PREPARE FOR REGULATORY SUBMISSION. COMPLETION OF THE PROPOSED PROJECT WILL DELIVER MULTIPATH UTI ID/AST TESTS READY FOR VERIFICATION AND VALIDATION STUDIES FOR REGULATORY SUBMISSION IN PHASE III.

DOD MANUFACTURING INNOVATION INSTITUTE, CROSS INSTITUTE COLLABORATIVE PROJECT: DIGITAL DATA MANAGEMENT FOR TRANSCRIBING STRUCTURAL PART PERFORMANCE ACROSS ADDITIVE MANUFACTURING PLATFORMS

GLOBAL SAFETY INFORMATION PROJECT

GLOBAL INFORMATION SAFETY PROJECT

LIVELIHOOD, ECONOMIC, ACCOUNTABLE AND PROTECTIVE SOLUTIONS (LEAPS) FOR REFUGEES AND HOST COMMUNITIES

HIGH EFFICIENCY DRIVING ELECTRONICS FOR GENERAL ILLUMINATION LED LUMINAIRES

RYAN WHITE PART C OUTPATIENT EIS PROGRAM

A PROJECT TO TEST THE EFFICACY AND SAFETY OF AN INNOVATIVE TREATMENT FOR OPIATE USE DISORDERS. - PROJECT SUMMARY/ABSTRACT THIS PROJECT IS TO DEMONSTRATE THAT A NOVEL TREATMENT FOR OPIATE ADDICTION, AS DEFINED BY DSM 5, IS SAFE AND FAR SUPERIOR TO A SHAM COMPARISON TREATMENT WHEN USED AS A STAND-ALONE TREATMENT. THE TREATMENT IS HOPED TO SIGNIFICANTLY AID IN THE BATTLE AGAINST THE OPIATE EPIDEMIC THAT IS RAVAGING MUCH OF OUR COUNTRY AND THE WORLD. THE TREATMENT CONSISTS OF USING A 4-MINUTE APPLICATION OF UNILATERAL TRANSCRANIAL PHOTOBIOMODULATION, NEAR INFRA-RED MODE, THROUGH A SUPRA-LUMINOUS LED, TO ONE SIDE OF THE FOREHEAD OVER THE BRAIN HEMISPHERE THAT WE DETERMINE (THROUGH A PROPRIETARY TEST) TO HAVE A MORE POSITIVE EMOTIONAL VALENCE. BASED ON ROBUST PRELIMINARY DATA, INCLUDING A COMPLETED, PUBLISHED PHASE I STUDY, WE ANTICIPATE THAT THE TREATMENT WILL BE VERY EFFECTIVE IN REDUCING DRUG USE AND RELAPSES AS WELL AS CRAVINGS, AND OVERALL CLINICAL STATE AND FUNCTIONING. AIM I WILL OFFER ONCE OR TWICE WEEKLY (IN EQUAL NUMBERS) TREATMENTS TO TWO GROUPS, ACTIVE AND SHAM, FOR 25-WEEKS WITH 1 WEEKLY FOLLOW-UP AND WILL LOOK SPECIFICALLY FOR DIFFERENCES IN OPIOID ABSTINENCE, OPIOID USE, CRAVINGS, AND GENERAL PSYCHOLOGICAL AND FUNCTIONING STATE. ALL THE PATIENTS WILL BE USING OPIOIDS AT ENROLLMENT AND WILL BE ON NO OPIOID USE DISORDER TREATMENT. WE WILL EVALUATE PATIENTS CLOSELY FOR SAFETY AND EFFICACY DURING THE STUDY. IN AIM II WE WILL WORK WITH TO DEVELOP LED DEVICES THAT PASS REGULATORY REQUIREMENTS AND APPLY FOR AN FDA BREAKTHROUGH TREATMENT DESIGNATION. WE WILL WORK WITH THE FDA TOWARD ACHIEVING EVENTUAL APPROVAL FOR THIS TREATMENT OF OPIOID USE DISORDER. MINDLIGHT’S EXECUTIVE TEAM WILL WORK CLOSELY WITH GARRETT TECHNOLOGIES, INC. BUSINESS AND ENGINEERING PERSONNEL, TO ACHIEVE EVENTUAL, SUCCESSFUL COMMERCIALIZATION SO THAT THE NOVEL TREATMENT MIGHT BECOME WIDELY AVAILABLE TO THOSE IN NEED. THE THERAPY IS BASED ON HYPOTHESES FROM THE MINDLIGHT FOUNDER’S PSYCHOLOGICAL THEORY, DUAL-BRAIN PSYCHOLOGY, AND PUBLISHED EXPERIMENTS HAVE WELL SUPPORTED THOSE THEORIES.

MICRONEEDLE BASED TARGETED ALLERGEN SPECIFIC IMMUNOTHERAPY FOR TREATMENT OF PEANUT ALLERGIES

SCALING UP MULTI SECTOR RESPONSE IN SOUTH SUDAN

RESILIENCE AND LIFE SAVING AWARD INTEGRATING - PROTECTION, ERMS, WASH, SHELTER IN SOUTH SUDAN

HUMANITARIAN ASSISTANCE

VA IS PROVIDING PER DIEM FUNDING TO ASSIST WITH THE OPERATIONAL COSTS ASSOCIATED WITH TRANSITIONAL HOUSING BEDS FOR HOMELESS VETERANS.

FOREIGN ASSISTANCE: EMERGENCY ASSIISTANCE TO IDP''S

CHILD ABUSE AND NEGLECT DISCRETIONARY PROJECTS

PORT SECURITY GRANT PROGRAM (ARRA)

AMERICORPS*NATIONAL

NEW AWARD UNDER THE NEW PARTNERS INTIATIVE

THE SSVF PROGRAM'S PURPOSE IS TO PROVIDE SUPPORTIVE SERVICES GRANTS TO PRIVATE NON-PROFIT ORGANIZATIONS AND CONSUMER COOPERATIVES, WHO WILL COORDINATE OR PROVIDE SUPPORTIVE SERVICES TO VERY LOW-INCOME VETERAN FAMILIES WHO ARE RESIDING IN PERMANENT HOUSING, ARE HOMELESS AND SCHEDULED TO BECOME RESIDENTS OF PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD; OR AFTER EXITING PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD, ARE SEEKING OTHER HOUSING THAT IS RESPONSIVE TO SUCH VERY LOW-INCOME VETERAN FAMILY'S NEEDS AND PREFERENCES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES.

THE SSVF PROGRAM'S PURPOSE IS TO PROVIDE SUPPORTIVE SERVICES GRANTS TO PRIVATE NON-PROFIT ORGANIZATIONS AND CONSUMER COOPERATIVES, WHO WILL COORDINATE OR PROVIDE SUPPORTIVE SERVICES TO VERY LOW-INCOME VETERAN FAMILIES WHO ARE RESIDING IN PERMANENT HOUSING, ARE HOMELESS AND SCHEDULED TO BECOME RESIDENTS OF PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD; OR AFTER EXITING PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD, ARE SEEKING OTHER HOUSING THAT IS RESPONSIVE TO SUCH VERY LOW-INCOME VETERAN FAMILY'S NEEDS AND PREFERENCES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES.

THE SSVF PROGRAM'S PURPOSE IS TO PROVIDE SUPPORTIVE SERVICES GRANTS TO PRIVATE NON-PROFIT ORGANIZATIONS AND CONSUMER COOPERATIVES, WHO WILL COORDINATE OR PROVIDE SUPPORTIVE SERVICES TO VERY LOW-INCOME VETERAN FAMILIES WHO ARE RESIDING IN PERMANENT HOUSING, ARE HOMELESS AND SCHEDULED TO BECOME RESIDENTS OF PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD; OR AFTER EXITING PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD, ARE SEEKING OTHER HOUSING THAT IS RESPONSIVE TO SUCH VERY LOW-INCOME VETERAN FAMILY'S NEEDS AND PREFERENCES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES.

PORT SECURITY GRANT PROGRAM

NEW SBIR PHASE I 2009: RADIATION HARD GAAS PHOTOMULTIPLIER CHIP(TM); PI - ERIC SPANGLER HARMON

COOPERATIVE AGREEMENT TO SUPPORT NAVIGATORS IN FEDERALLY-FACILITATED EXCHANGES

ENGAGEMENT, TREATMENT, RETENTION PROJECT (ETR PROJECT)

RETINAL EYE-TRACKING AS A PROGNOSTIC TOOL FOR TRAUMATIC BRAIN INJURY AND CONCUSSION - ABSTRACT THE GOAL OF OUR PROJECT IS TO FURTHER DEVELOP THE TRACKING SCANNING LASER OPHTHALMOSCOPE (TSLO), THE RETITRACK DEVICE, TO ENABLE WIDESPREAD USE OF THE TECHNOLOGY FOR HIGH-RESOLUTION EYE- TRACKING FOR HEAD INJURIES, SUCH AS MILD TRAUMATIC BRAIN INJURY (MTBI)/CONCUSSIONS. PHASE I OF THIS GRANT ENABLED THE COLLECTION OF DATA FROM 50 PATIENTS WHO HAD RECENTLY BEEN DIAGNOSED WITH A CONCUSSION BOTH DURING THEIR ACUTE RECOVERY PERIOD AND UPON CLEARANCE. ACCOUNTING FOR AGE AND TIME SINCE INJURY, FIXATIONAL EYE MOTION METRICS WERE ABLE TO PREDICT INDIVIDUALS WITH PROLONGED RECOVERY (AUC=0.81; 95% CI: 0.68-0.93; P<0.001). THE RETITRACK BRINGS AN UNPRECEDENTED LEVEL OF ACCURACY OF EYE TRACKING TO THE CLINIC BY USING AN IMAGE-BASED RETINAL APPROACH RESULTING IN MOTION MEASUREMENTS WITH A SENSITIVITY OF 0.25 ARCMIN (~1 MICRON). CURRENTLY, THIS SYSTEM IS THE MOST ACCURATE, FAST AND FUNCTIONAL EYE-TRACKING SYSTEM USED IN A STANDARD OPHTHALMIC INSTRUMENT. RESEARCH HAS SUGGESTED THAT PUPIL EYE-TRACKING TECHNOLOGIES HAVE VALIDATED THE IDEA OF USING EYE MOVEMENTS AS A BIOMARKER OF CONCUSSION, BUT THE CURRENT EYE-TRACKERS AVAILABLE LACK THE CAPACITY, REPEATABILITY, AND SENSITIVITY TO PREDICT RECOVERY IN MTBI. THE RETITRACK DEVICE CAN ACCURATELY MEASURE FIXATIONAL EYE MOVEMENTS (FEMS), QUANTIFY RETINAL SACCADES AT AN UNPRECEDENTED LEVEL, AND CAN BECOME AN EMERGING BIOMARKER OF MTBI PROGNOSIS. FURTHERMORE, IT CAN SERVE AS AN INDICATOR OF SEVERITY IN THE SYMPTOMATOLOGY OF MULTIPLE OTHER NEUROLOGICAL DISORDERS. THE RETITRACK DEVICE AS A CONCUSSIVE PROGNOSTIC TOOL WOULD BE THE PERFECT FIT FOR SPORT MEDICINE CLINICS AND THE LOCKER ROOM FOR POST-CONCUSSION RECOVERY MONITORING ENSURING A SAFE RETURN TO ACTIVITY AND MITIGATING LONG-TERM CONSEQUENCES OF CONCUSSION BY GUIDING THE MOST EFFECTIVE THERAPIES. FURTHER OPTIMIZATION OF FIXATIONAL TASKS AND THE CONSTRUCTION OF INNOVATIVE SOFTWARE THAT USES ARTIFICIAL INTELLIGENCE ALGORITHMS TO AUTOMATICALLY QUANTIFY RETINAL MICROSACCADES WHICH WILL LEAD TO THE IMPROVEMENT OF PREDICTING THE RECOVERY AND/OR WORSENING OF CONCUSSION.

AMERICORPS NATIONAL

TO SUPPLY CAPITAL IN DEVELOPING COUNTRIES AND COMMUNITIES IN VULNERABLE SITUATIONS IN THEIR EFFORTS TO ADAPT TO AND MANAGE THE IMPACTS OF CLIMATE CHANGE BY HELPING COMPANIES WITH CLIMATE RESILIENCE SOLUTIONS TO APPLY THEIR INNOVATIVE SOLUTIONS WHERE

DEVELOPMENT OF A PULMONARY FLOW RESTRICTOR FOR HYPOPLASTIC LEFT HEART SYNDROME - ABSTRACT STARLIGHT CARDIOVASCULAR IS DEVELOPING WHAT WILL BE THE FIRST FDA APPROVED PERCUTANEOUS FLOW RESTRICTOR TO REPLACE SURGICAL BANDING IN CONGENITAL HEART DISEASE (CHD). MANY BABIES WITH CHDS SUCH AS HYPOPLASTIC LEFT HEART SYNDROME AND COMMUNICATING HEART DEFECTS HAVE OVERCIRCULATION TO THE LOWER-RESISTANCE PULMONARY BED AND UNDERCIRCULATION TO THE REST OF THE BODY. REDUCING PULMONARY ARTERY FLOW IN THESE BABIES CREATES A MORE PHYSIOLOGIC BALANCE BETWEEN PULMONARY AND SYSTEMIC CIRCULATIONS AND ALLOWS THEM TO SURVIVE THE FIRST FEW WEEKS OF LIFE, REDUCES DAMAGE TO THEIR PULMONARY ARTERIES, AND ENABLES THEM TO GROW LARGER AND STRONGER PRIOR TO THEIR NEXT, MORE INVASIVE SURGERY TO REPAIR THEIR HEART DEFECT. CURRENTLY, THE REDUCTION OF PULMONARY BLOOD FLOW IN THESE NEONATAL PATIENTS IS ACHIEVED BY SURGICAL PULMONARY ARTERY BANDING, BUT BANDING REQUIRES AN OPEN-CHEST SURGERY AND CAN INTERFERE WITH PULMONARY ARTERY GROWTH, THUS LIMITING ITS CLINICAL UTILITY. A PERCUTANEOUS SOLUTION COULD ELIMINATE AN OPEN CHEST SURGERY FOR A NEWBORN. PEDIATRIC INTERVENTIONAL CARDIOLOGISTS HAVE SO MUCH INTEREST IN OVERCOMING THE NEGATIVE EFFECTS OF BANDING THAT THEY ARE PERFORATING VASCULAR PLUGS TO CREATE HAND-MADE PERCUTANEOUS PULMONARY FLOW RESTRICTORS, AND EARLY CLINICAL USE OF THESE DEVICES HAVE PRODUCED PROMISING RESULTS. HOWEVER, USE OF THESE MODIFIED VASCULAR PLUGS IS LIMITED BY TECHNICAL CHALLENGES SUCH AS LONG IMPLANT LENGTHS, DEVICE MIGRATION, AND LACK OF ADJUSTABILITY AND RELIABILITY. ADDITIONALLY, MANY CLINICIANS ARE UNCOMFORTABLE WITH MODIFYING AN OCCLUDER BY HAND AND USING IT OFF-LABEL. STARLIGHT CARDIOVASCULAR IS DEVELOPING A CATHETER-DELIVERED, PERCUTANEOUS, AND ADJUSTABLE BRANCH PULMONARY ARTERY BLOOD FLOW RESTRICTOR TO REPLACE SURGICAL BANDING. OUR DEVICE ADDRESSES THE SHORTCOMINGS FROM PREVIOUS ATTEMPTS AT A PERCUTANEOUS FLOW RESTRICTOR BY PROVIDING RELIABLE FLOW REDUCTION, PERCUTANEOUS ADJUSTABILITY, AND A SHORT AND WELL-ANCHORED IMPLANT DESIGN THAT IS REMOVABLE. THESE PULMONARY FLOW RESTRICTORS COULD BENEFIT AS MANY AS 130,000 BABIES BORN EACH YEAR WITH CHDS INCLUDING HYPOPLASTIC LEFT HEART SYNDROME, VENTRICULAR SEPTAL DEFECTS, AND TRUNCUS ARTERIOSUS. THIS PHASE II SBIR GRANT WILL CONSIST OF DEVICE DESIGN OPTIMIZATION THROUGH DESIGN ITERATION, BENCHTOP TESTING, END-USER SIMULATED USE TESTING BY PEDIATRIC INTERVENTIONAL CARDIOLOGISTS, AND ACUTE AND CHRONIC ANIMAL STUDIES. SUCCESSFUL COMPLETION OF THIS PROJECT WILL PRODUCE A FINAL DEVICE DESIGN THAT IS READY FOR FORMAL VERIFICATION AND VALIDATION TESTING, CLINICAL STUDIES, FDA APPROVAL, AND COMMERCIALIZATION.

HIGH ENERGY COST GRANT

NONINVASIVE CONTRAST ENHANCED EARLY DETECTION OF MELANOMA LIVER METASTASIS

DETECTION AND STAGING OF LIVER FIBROSIS BY PRECISE MRI (PMRI)

BUILDING RESILIENCE AND SELF-RELIANCE OF THE REFUGEES LIVING IN RWANDA

SCALE-UP MANUFACTURING OF MICRONEEDLE STAMP FOR PEANUT ALLERGEN IMMUNOTHERAPY - THE FOLLOWING CONTAINS PROPRIETARY/PRIVILEGED INFORMATION THAT MOONLIGHT THERAPEUTICS REQUESTS NOT BE RELEASED TO PERSONS OUTSIDE THE GOVERNMENT, EXCEPT FOR PURPOSES OF REVIEW AND EVALUATION SCALE-UP MANUFACTURING OF MICRONEEDLE STAMP FOR PEANUT ALLERGEN IMMUNOTHERAPY FOOD ALLERGIES AFFECT 30 MILLION PEOPLE IN THE USA AND 17 MILLION IN EUROPE. SIX MILLION CHILDREN, ROUGHLY 1 IN 13, IN THE USA HAVE AT LEAST ONE FOOD ALLERGY; THIS EQUATES TO AT LEAST 1 IN EVERY CLASSROOM. CURRENTLY, THERE IS ONLY ONE FDA APPROVED THERAPY IN THE USA FOR FOOD ALLERGIES. FOOD ALLERGIES ARE EXPECTED TO GROW 10% ANNUALLY UNTIL AT LEAST 2022. IT IS ALSO COMMON FOR SOMEONE TO HAVE MORE THAN ONE ALLERGY. THIS IS A GROWING, UNDERSERVED GLOBAL MARKET THAT HAS FEW TREATMENT OPTIONS. A MEANINGFUL INITIAL THERAPY WOULD BE ONE THAT REDUCES THE CHANCE FOR ANAPHYLACTIC REACTION AFTER ACCIDENTAL EXPOSURE. SUCH A THERAPY WILL HELP BRING PEACE OF MIND TO FAMILIES, ALLOW FOR CHILDREN AFFECTED BY FOOD ALLERGIES TO HAVE BETTER QUALITY OF LIFE, FEEL LESS SOCIALLY OUT CASTED AND MOST IMPORTANTLY REDUCE THE POTENTIAL FOR DEATH FROM ACCIDENTAL PROCEDURE. MOONLIGHT THERAPEUTICS IS DEVELOPING A TARGETED WAY TO ADMINISTER ALLERGENS INTO THE TOP SKIN LAYERS TO DESENSITIZE AN ALLERGIC PATIENT, USING MICRONEEDLES APPLIED TO THE SKIN FOR ONLY A FEW MINUTES. MICRONEEDLES CAN DELIVER INTO TOPMOST SKIN LAYERS, NEAR IMMUNE CELLS, WITH HIGH PRECISION AND REPRODUCIBILITY. THE COMPANY’S FIRST TREATMENT IS FOCUSED ON PEANUT ALLERGY AND IS CALLED MOON101. WE HAVE DEMONSTRATED EFFICACY OF OUR APPROACH IN A PRE-CLINICAL MOUSE MODEL OF PEANUT SENSITIZATION, COMPLETED A PRE-IND MEETING WITH THE FDA AND RECEIVED A U44 CLINICAL TRIAL GRANT TO CONDUCT THE FIRST EVER CLINICAL STUDY TO EVALUATE THE SAFETY AND TOLERABILITY OF MOON101 IN PEANUT ALLERGIC SUBJECTS. THE OBJECTIVE OF THE CRP GRANT IS TO IMPROVE THE CURRENT MICRONEEDLE COATING METHOD SO THAT LARGE-SCALE CLINICAL TRIALS FOR SAFETY AND EFFICACY CAN BE CONDUCTED. THERE ARE 2 MAIN IMPROVEMENTS THAT WILL BE THE FOCUS OF THE NEW DROP-ON-DEMAND COATING SYSTEM: (1) AN AUTOMATED COATING METHOD FOR MICRONEEDLES TO ALLOW FOR INCREASED PRODUCTION RATE AND (2) THE ABILITY TO CONCURRENTLY COAT DIFFERENT ALLERGENS ONTO A SINGLE MICRONEEDLE ARRAY. WE HAVE IDENTIFIED A PARTICULAR PIECE OF EQUIPMENT THAT CAN BE CUSTOMIZED TO SUIT OUR NEEDS. OUR APPROACH WILL BE TO PURCHASE THIS EQUIPMENT, SET IT UP AND DEMONSTRATE THAT IT CAN BE USED FOR CLINICAL PRODUCTION OF MOON101. WE WILL FIRST EVALUATE IT FOR COATING OF PEANUT ALLERGENS, AND THEN DETERMINE IF WE CAN COAT MULTIPLE ALLERGENS SIMULTANEOUSLY. THIS WILL ADDRESS FUTURE NEEDS OF TREATING MULTIPLE ALLERGIES CONCURRENTLY. OVERALL, THIS GRANT WILL ENABLE MOONLIGHT THERAPEUTICS TO ADVANCE THE PRODUCTION CAPABILITIES OF THEIR PLATFORM. IT WILL SET THE STAGE TO EVALUATE THE EFFICACY OF MOON101 TO TREAT PEANUT ALLERGY IN A PHASE 2 CLINICAL TRIAL AND BEGIN TO ADDRESS TREATMENT OF MULTIPLE FOOD ALLERGIES.

NON-INVASIVE STAGING OF METASTASIS BY PRECISION MRI - PROJECT SUMMARY/ABSTRACT THIS SBIR APPLICATION WILL DEVELOP AN IMPROVED CONTRAST AGENT FOR PRECISION STAGING THROUGH EARLY AND ACCURATE DETECTION OF PANCREATIC DUCTAL ADENOCARCINOMA (PDAC) LIVER METASTASIS. WE HAVE CREATED AN INNOVATIVE PLATFORM TECHNOLOGY USING A NEW CLASS OF PROTEIN-BASED MRI CONTRAST AGENTS (PROCAS) FOR CONTRAST-ENHANCED MRI. WE HAVE DEVELOPED AN EFFECTIVE APPROACH TO GENERATE PROTEIN CONTRAST AGENTS AGAINST AN ARRAY OF MOLECULAR BIOMARKERS INCLUDING COLLAGEN I (PROCA32.COLLAGEN). THIS EXTRACELLULAR MATRIX PROTEIN IS HIGHLY EXPRESSED IN THE TUMOR MICROENVIRONMENT AND ITS EXPRESSION LEVELS AND CROSSLINKING INCREASE UPON PROGRESSION. PROCA32.COLLAGEN EXHIBITS 10- TO 50-FOLD INCREASE IN BOTH R1 AND R2 RELAXIVITIES, COMPARED TO CLINICALLY-APPROVED GD3+ CONTRAST AGENTS, RESULTING IN EXCEPTIONAL IMAGING CAPABILITY THAT CAN DISCERN HETEROGENEOUS TISSUE SIGNALS VIA A DUAL MR IMAGING METHODOLOGY. PROCA32.COLLAGEN HAS STRONG COLLAGEN BINDING AFFINITY, ENABLES EARLY DETECTION OF SMALL LIVER METASTASES <0.2 MM AND ALLOWS FOR MAPPING TUMOR HETEROGENEITY IN SEVERAL MURINE XENOGRAFT TUMOR MODELS; A 100-FOLD IMPROVEMENT IN THE DETECTION LIMIT OVER CLINICAL CONTRAST AGENTS. PROCA32.COLLAGEN IS EXPECTED TO HAVE A LOW RISK RELATED TO METAL TOXICITY DUE TO ITS UNPRECEDENTED METAL BINDING SELECTIVITY AND KINETIC STABILITY, PROLONGED BLOOD RETENTION AND ADEQUATE BIODISTRIBUTION, WHICH PERMITS HIGH QUALITY IMAGING AT LOW DOSES. THIS PROPOSAL WILL TEST THE HYPOTHESIS THAT A NON- INVASIVE, IN VIVO MRI FOR ACCURATE STAGING OF PDAC THROUGH DETECTION OF SUBCLINICAL LIVER METASTASES CAN BE ACHIEVED BY FURTHER OPTIMIZING THE COLLAGEN TARGETED PROCA32.COLLAGEN+ CONTRAST AGENT. THIS SERIES OF PRECLINICAL STUDIES WILL PROVIDE DATA SUCH AS FORMULATION AND SAFETY PROFILE NEEDED TO SUBMIT AN FDA INVESTIGATIONAL NEW DRUG (IND) APPLICATION FOR AN EARLY PHASE CLINICAL TRIAL. THIS APPLICATION WILL IMPROVE DETECTION OF SUBCLINICAL METASTASIS AND HAVE BROAD IMPACT FOR PDAC.

PROVIDING ASSISTANCE & PROMOTING THE WELLBEING AND SELF-RELIANCE OF CONGOLESE REFUGEES IN KIZIBA, GIHEMBE, NYABIHEKE, KIGEME AND MUGOMBWA

COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - NON-CONSTRUCTION - LIFEFLIGHT OF MAINE IS A PRIVATE NON-PROFIT WITH AN IMPORTANT PUBLIC, STATEWIDE MISSION AS MAINE’S ONLY CRITICAL CARE AMBULANCE SERVICE; TO ENSURE THAT EVERYONE, IN EVERY COMMUNITY, HAS ACCESS TO CRITICAL CARE AND MEDICAL TRANSPORT WHEN NEEDED. LIFEFLIGHT PARTNERS WITH EVERY HOSPITAL AND EMERGENCY MEDICAL SERVICE (EMS) AGENCY IN THE STATE, ASSURING TIMELY ACCESS TO TERTIARY CARE FOR CRITICALLY ILL AND INJURED PATIENTS OF ALL AGES AND DISEASES. SINCE 1998, LIFEFLIGHT’S HIGHLY SKILLED AND TRAINED MEDICAL CREWS HAVE PROVIDED ICU-LEVEL CARE, CONSISTENT WITH PHYSICIANS, TO MORE THAN 38,000 PATIENTS. THE COMBINATION OF MAINE’S VAST EXPANSE, RUGGED LANDSCAPE, CHALLENGING WEATHER, RURAL POPULATION, AND A FRAGILE AND FRAGMENTED HEALTHCARE SYSTEM DEMANDS AN EQUALLY COMPLEX AND DELIBERATELY DESIGNED MEDICAL TRANSPORT FLEET THAT CONNECTS MAINE’S MOST ILL AND INJURED PATIENTS TO THE CARE THEY NEED. LIFEFLIGHT OF MAINE IS THAT CONNECTOR. LIFEFLIGHT CURRENTLY OWNS AND OPERATES HELICOPTERS, AN AIRPLANE, AND PARTNERS WITH EMS PROVIDERS WHO OWN GROUND AMBULANCES. FOR THE LAST 26 YEARS, LIFEFLIGHT HAS RELIED ON PARTNER-OWNED AMBULANCES FOR ITS GROUND TRANSPORTS. THE EMS AGENCY SUPPLIES AN AMBULANCE AND AN EMERGENCY MEDICAL TECHNICIAN DRIVER, WHILE LIFEFLIGHT PROVIDES THE CRITICAL CARE TEAM AND SPECIALIZED EQUIPMENT. HOWEVER, MAINE EMS AGENCIES ARE IN CRISIS DUE TO COMPLEX FINANCIAL CHALLENGES AND STAFFING ISSUES. THE AGENCIES ARE UNABLE TO PROVIDE RELIABLE RESOURCES FOR LIFEFLIGHT’S EMERGENCY INTER-HOSPITAL TRANSPORTS BECAUSE OF THEIR OWN 911 EMERGENCY RESPONSE CALLS. FURTHERMORE, PARTNER EMS AGENCIES ARE NOT LICENSED TO PROVIDE CRITICAL CARE AND THEIR VEHICLES ARE OFTEN NOT EQUIPPED TO SUPPORT COMPLEX PATIENTS DURING TRANSFER, ESPECIALLY REGARDING THE ELECTRICAL REQUIREMENTS OF LIFEFLIGHT’S MEDICAL TECHNOLOGY. LIFEFLIGHT INCURS THE COST OF CRITICAL CARE SERVICES PROVIDED AND RECEIVES NO REIMBURSEMENT FOR THOSE SERVICES, AS ONLY THE AGENCY DIRECTLY PROVIDIN G THE TRANSPORT CAN BILL FOR SERVICES. THIS PRACTICE IS UNSUSTAINABLE AND DIMINISHES LIFEFLIGHT’S ABILITY TO CARE FOR CRITICALLY ILL OR INJURED PATIENTS WHEN EVERY MINUTE MATTERS. LIFEFLIGHT HAS IDENTIFIED THE GROWING NEED TO ENHANCE AND EXPAND PATIENT CARE BY SECURING ITS OWN SPECIALIZED GROUND AMBULANCES. LIFEFLIGHT CARES FOR 2,500+ PATIENTS ANNUALLY AND IS PROJECTED TO SERVE 4,000 PATIENTS A YEAR BY 2030. NEARLY 90% OF TRANSPORTS ARE INTER-HOSPITAL. LIFEFLIGHT IS THE ONLY OPTION TO CONNECT CRITICALLY ILL OR INJURED PATIENTS QUICKLY AND SAFELY TO THE CARE THEY NEED. THESE PATIENTS RANGE FROM PREMATURE INFANTS AND SERIOUSLY INJURED CHILDREN TO ADULTS AND SENIORS WHO NEED SPECIALTY CARE. FOR NON-TIME URGENT, HIGH ACUITY TRANSPORTS OR WHEN LIFEFLIGHT’S AIRCRAFT ARE UNABLE TO FLY DUE TO WEATHER CONDITIONS OR MAINTENANCE, GROUND VEHICLES ARE A CRITICAL COMPONENT TO THE FLEET. GROUND TRANSPORTS ACCOUNT FOR APPROXIMATELY 25% OF LIFEFLIGHT’S MISSIONS AND DEMAND IS INCREASING. AS ALL LIFEFLIGHT SERVICES ARE EMERGENT, GROUND VEHICLES AND TRAINED DRIVERS MUST BE IMMEDIATELY AVAILABLE. LIFEFLIGHT HAS INITIATED PURCHASING ITS OWN GROUND MOBILE INTENSIVE CARE AND NEWBORN UNITS TO MEET INCREASING NEED AND RELIABILITY. THE VEHICLES WILL OPERATE OUT OF LIFEFLIGHT’S THREE BASES OF OPERATION—BANGOR, LEWISTON, AND SANFORD. TO ENSURE THE GROUND VEHICLES ARE STAFFED AND IMMEDIATELY READY FOR SERVICE ONCE ACQUIRED, LIFEFLIGHT WILL HIRE AND TRAIN 16 NEW FULL-TIME EMPLOYEES. LIFEFLIGHT WILL EQUIP THE SPECIALLY DESIGNED AMBULANCES WITH FULL MOBILE ICU TECHNOLOGY INCLUDING VENTILATORS, INFUSION PUMPS, INVASIVE CARDIAC, PULMONARY, AND NEURO SYSTEMS, LABORATORY, ULTRASOUND, BLOOD, AND PHARMACY AT AN ESTIMATED COST OF $400,000 PER VEHICLE. THE INITIAL PURCHASE OF THREE SPECIALIZED VEHICLES, SUPPORTED BY CDS FUNDING, WILL ENHANCE LIFEFLIGHT’S CURRENT GROUND CAPABILITY, ASSURING LIFEFLIGHT’S ABILITY TO RESPOND TO A PROJECTED 300% INCREASE IN GROUND CRITICAL CARE TRANSPORT OVER THE NEXT 5- 7 YEARS.

FERTILIZER PRODUCTION EXPANSION PROGRAM 2.0

PRIMARY HEALTH CARE, MICRO-ENTERPRISE DEV. (MED), WASH, AND GBV CAPACITY STRENGTHENING FOR BURMESE & ETHNIC MINORITY REFUGEES ON THAI-BURMA BORDER

LIFT - ADVANCING MANUFACTURING TECHNOLOGY & TALENT IN PUERTO RICO

PROVIDING PROTECTION ASSISTANCE AND IMPROVING THE WELLBEING OF REFUGEES FROM DRC RESIDING IN GIHEMBE, NYABIHEKE, KIZIBA AND KIGEME CAMPS IN RWANDA

COMPREHENSIVE SUPPORT SERVICES FOR FAMILIES AFFECTED BY SUBSTANCE ABUSE AND/OR HIV/AIDS

MOBILE ORAL CANCER SCREENING SYSTEM FOR LOW-RESOURCE SETTINGS - TWO-THIRDS OF ORAL AND OROPHARYNGEAL SQUAMOUS CELL CARCINOMA (OSCC) OCCUR IN LOW- AND MIDDLE-INCOME COUNTRIES (LMICS), THE 5-YEAR SURVIVAL RATE IS ONLY 10-40. ENOUGH IS ALREADY KNOWN ABOUT THE DISEASE AND ITS PREVENTION FOR ACTION TO BE TAKEN. THE POOR SURVIVAL RATE IN LMICS IS MAINLY DUE TO LATE DIAGNOSIS. THEREFORE, IT IS IMPERATIVE TO DETECT PRECURSOR AND MALIGNANT LESIONS EARLY AND EXPEDITIOUSLY. TO MEET THE NEED FOR TECHNOLOGIES THAT ENABLE ORAL CANCER SCREENING AND DIAGNOSIS IN LOW RESOURCE SETTINGS (LRS), LIGHT RESEARCH INC (LRI) WILL DEVELOP, VALIDATE, AND COMMERCIALIZE A LOW-COST SMARTPHONE-BASED IMAGING SYSTEM THAT PROVIDES REMOTE SPECIALIST ACCESS AND TRIAGE DECISION-MAKING GUIDANCE TAILORED TO NON-SPECIALIST USE IN LRS. TO ACHIEVE THE PROJECT GOAL, LRI WILL LICENSE TECHNOLOGIES FROM UNIVERSITY OF ARIZONA (UA), AND PARTNER WITH UA AND MAZUMDAR-SHAW CANCER CENTER (MSCC) (BANGALORE, INDIA) TO DEVELOP AND VALIDATE A MULTIMODAL MOBILE ORAL IMAGING SYSTEM FOR ORAL CANCER DETECTION AND DIAGNOSIS IN LRS. IN THE PAST FEW YEARS, THE PROJECT TEAM HAS DEVELOPED AND EVALUATED A DUAL-MODE (POLARIZED WHITE LIGHT IMAGING [PWLI]) AND AUTOFLUORESCENCE IMAGING [AFI])) MOBILE IMAGING DEVICE THAT SPECIFICALLY ADDRESSES CRITICAL BARRIERS IN LRS TO IMPROVE ORAL CANCER SCREENING. TO ADDRESS ONE OF THE KEY HURDLES IN ADOPTING OPTICAL IMAGING TECHNIQUES FOR ORAL CANCER SCREENING IN LRS, THE TEAM HAS ALSO DEVELOPED AND EVALUATED CLOUD-BASED AND MOBILE-BASED DEEP LEARNING IMAGE CLASSIFICATION METHODS FOR GUIDING PATIENT TRIAGE. SINCE THE KEY TECHNIQUES PROPOSED IN THIS MOBILE IMAGING SYSTEM HAVE BEEN SUCCESSFULLY EVALUATED FOR ORAL CANCER SCREENING WITH 3,000 HIGH-RISK POPULATION IN LRS, THE POTENTIAL OF SUCCESSFULLY TRANSITIONING IT TO THE LOW- RESOURCE REGIONS FOR ACCURATE, OBJECTIVE AND LOCATION-RESOLVED DETECTION OF ORAL CANCER IS VERY HIGH. THE PROJECT OBJECTIVE WILL BE ACHIEVED THROUGH THREE AIMS: (1) TO OPTIMIZE A MOBILE INTRAORAL IMAGING SYSTEM FOR LRS, (2) TO OPTIMIZE DEEP LEARNING-BASED DUAL-MODALITY IMAGE CLASSIFICATION METHODS, AND (3) TO VALIDATE THE CLINICAL USEFULNESS OF THE MOBILE ORAL IMAGING SYSTEM FOR ORAL CANCER SCREENING AND TRIAGE IN LSR. SUCCESSFUL COMPLETION OF THIS PROJECT WILL LEAD TO A MOBILE ORAL IMAGING SYSTEM WITH DEEP LEARNING IMAGE CLASSIFICATION METHOD THAT DELIVERS URGENTLY-NEEDED CAPABILITIES TO THE END USERS IN LRS. LRI WILL PARTNER WITH JANA CARE INC (NEW DELHI, INDIA) FOR LOW-COST PRODUCTION, WITH ERGO HEALTHCARE (MUMBAI, INDIA) FOR PRODUCT DISTRIBUTION IN SOUTH AND SOUTHEAST ASIAN, AND WITH DENTALEZ GROUP FOR PRODUCT DISTRIBUTION IN AMERICA AND EUROPE. THE USE OF THIS MOBILE-BASED SCREENING APPROACH FOR EARLY DETECTION AND TRIAGE OF ORAL CANCERS WILL EVENTUALLY IMPROVE ORAL CANCER DETECTION RATES, TREATMENT OUTCOMES, AND QUALITY OF LIFE OF PATIENTS IN LRS.

COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - CONSTRUCTION

PRIMARY HEALTH CARE, MICRO-ENTERPRISE DEVELOPMENT, AND GBV CAPACITY STRENGTHENING FOR BURMESE AND ETHNIC MINORITY REFUGEES

PRIMARY HEALTH CARE AND GBV CAPACITY STRENGTHENING FOR BURMESE AND ETHNIC MINORITY REFUGEES ON THE THAI-BURMESE BORDER

FIRELIGHT MEDIA?S SPARK FUND FOR FILMMAKERS OF COLOR WORKING ON HUMANITIES FILMS [FOUNDED BY STANLEY NELSON, FIRELIGHT MEDIA, INC. IS A CREATOR OF ACCLAIMED HISTORICAL DOCUMENTARY FILMS, KNOWN FOR ITS PROGRAMS THAT BENEFIT BIPOC FILMMAKERS WHO PRODUCE RICH HUMANITIES-THEMED DOCUMENTARIES, THAT WILL INCREASE ITS CAPACITY TO NURTURE AND SUPPORT A PIPELINE OF HISTORICAL NONFICTION MEDIA. FIRELIGHT WILL RELEASE AN RFP OFFERING 12-MONTH STIPENDS FOR MID-CAREER FILMMAKERS OF COLOR, WHOSE WORK ON THEIR HISTORICAL OR HUMANITIES-FOCUSED FILM WAS DISRUPTED BY THE COVID PUBLIC HEALTH EMERGENCY. WITH THE SUPPORT OF AN EXTERNAL SELECTION COMMITTEE COMPOSED OF HUMANITIES SCHOLARS, RENOWNED HISTORICAL DOCUMENTARY FILMMAKERS, AND EDUCATORS, FIRELIGHT WILL ADD THIS NEW FUND TO ITS EXISTING GRANT-MAKING ACTIVITIES, WHICH ALSO INCLUDE NON-MONETARY SUPPORT IN THE FORM OF MENTORSHIP, PROJECT SUPPORT, AND NETWORKING OPPORTUNITIES.] [PURPOSE: EMERGENCY RELIEF FOR FILMMAKERS WORKING ON HISTORICAL OR HUMANITIES-FOCUSED DOCUMENTARY FILM PROJECTS. ACTIVITIES TO BE PERFORMED: ADMINISTRATION OF A GRANTMAKING PROGRAM COMPRISED OF 36 12-MONTH STIPENDS OF $50,000. THIS PROGRAM WILL ALSO CONVENE HUMANITIES ADVISORS TO SUPPORT INDIVIDUALS DEVELOPING HUMANITIES PROJECTS IN ACTIVE DEVELOPMENT, PRODUCTION, OR POST-PRODUCTION OF FILMS. EXPECTED OUTCOMES: EMERGENCY RELIEF TO 36 HUMANITIES FILMMAKERS. INTENDED BENEFICIARIES: MID-CAREER BLACK, INDIGENOUS, AND PEOPLE OF COLOR FILMMAKERS. SUBRECIPIENT ACTIVITIES: DEVELOPMENT OF HISTORICAL OR HUMANITIES-FOCUSED DOCUMENTARY FILM PROJECTS DISRUPTED BY THE CORONAVIRUS PANDEMIC.]

PRIMARY HEALTHCARE AND GBV CAPACITY STRENGHTENING FOR BURMESE AND ETHNIC MINORITY REFUGEES ON THE THAI-BURMESE BORDER

PRIMARY HEALTH CARE AND GBV CAPACITY STRENGTHENING FOR BURMESE AND ETHNIC MINORITY REFUGEES ON THE THAI-BURMESE BORDER

TAS::89 0331::TAS RECOVERY NEW SOLID STATE LIGHTING (PRODUCT) AWARD #DE-EE0003245 ENTITLED "RECOVERY ACT: NITRIDE AND OXYNITRIDE-BASED PHOSPHORS FOR

PROMESA CCBHC EXPANSION - PROMESA'S CCBHC EXPANSION GRANT PROGRAM WILL ENHANCE ITS EXISTING NEW YORK STATE-FUNDED CCBHC (2017) TO ENSURE THAT CONSUMERS HAVE IMMEDIATE AND TIMELY ACCESS TO WELL-COORDINATED AND EVIDENCE-BASED TREATMENT THROUGH A SINGLE POINT OF ENTRY. THE PROGRAM WILL SERVE INDIVIDUALS WITH SERIOUS MENTAL ILLNESS, SEVERE SUBSTANCE USE DISORDER, AND THOSE WITH OCCURRING MENTAL, SUBSTANCE USE, AND/OR PHYSICAL HEALTH DISORDERS IN THE SOUTH BRONX IN NEW YORK CITY (NYC).

PRIMARY HEALTH CARE, MICRO-ENTERPRISE DEVELOPMENT, AND GBV CAPACITY STRENGTHENING FOR BURMESE AND ETHNIC MINORITY REFUGEES

PORT SECURITY GRANT PROGRAM

TO PROVIDE PARTIAL FINANCIAL SUPPORT TOWARDS "PRIMARY HEALTH CARE AND GBV ASSISTANCE AND CAPACITY STRENGTHENING FOR BURMESE AND ETHNIC MINORITY REFUG

THE SSVF PROGRAM'S PURPOSE IS TO PROVIDE SUPPORTIVE SERVICES GRANTS TO PRIVATE NON-PROFIT ORGANIZATIONS AND CONSUMER COOPERATIVES, WHO WILL COORDINATE OR PROVIDE SUPPORTIVE SERVICES TO VERY LOW-INCOME VETERAN FAMILIES WHO ARE RESIDING IN PERMANENT HOUSING, ARE HOMELESS AND SCHEDULED TO BECOME RESIDENTS OF PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD; OR AFTER EXITING PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD, ARE SEEKING OTHER HOUSING THAT IS RESPONSIVE TO SUCH VERY LOW-INCOME VETERAN FAMILY'S NEEDS AND PREFERENCES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES.

PRIMARY HEALTH CARE AND GBV ASSISTANCE AND CAPACITY STRENGTHENING FOR BURMESE AND ETHNIC MINORITY REFUGEES ON THE THAI-BURMESE BORDER

CF CONGRESSIONALLY DIRECTED GRANTS

HIGH-EFFICIENCY HSL/TPV COGENERATION FOR COMMERCIAL BUILDINGS

VISCERAL VR: IMMERSIVE HUMAN BIOLOGY FOR THE STUDY OF HEALTH AND DISEASE

HIGH-DEFINITION, WIDE FIELD OF VIEW CORNEAL IMAGING

WASH - HEALTHCARE, NUTRITION, SHELTER, GENDER-BASED VIOLENCE AND CONSTRUCTION SERVICES IN GIHEMBE, KIZIBA AND NYABIHEKE REFUGEE CAMPS.

WASH, HEALTHCARE, NUTRITION, SHELTER, GENDER-BASED VIOLENCE AND CONSTRUCTION SERVICES GIHEMBE, KIZIBA, AND NYABIHEKE REFUGEES CAMPS, RWANDA

ADVANCING A NOVEL PORTABLE DETECTION METHOD FOR CANNABIS INTOXICATION

SUPPORTING DURABLE REINTEGRATION IN MALAKAL, AWEIL, KAJO KEJI AND MADWI COUNTIES, SOUTH SUDAN.

IMPROVE EXISTING AIRPORT

IN VIVO HIGH-DEFINITION 3D CORNEAL IMAGING - THE CORNEA, THE OUTERMOST WINDOW OF OUR VISUAL SYSTEM, IS VULNERABLE TO VARIOUS TYPES OF INFECTIONS AND DISEASES. CORNEAL DISEASE IS ONE OF THE LEADING CAUSES OF VISUAL DEFICIENCY AND BLINDNESS, AND IS CONSIDERED THE SECOND MAJOR CAUSE OF BLINDNESS IN DEVELOPING COUNTRIES. THERE ARE NEARLY 5 MILLION BILATERALLY CORNEAL BLIND PERSONS WORLDWIDE, AND AN ESTIMATED 23 MILLION PEOPLE AFFECTED BY UNILATERAL CORNEAL BLINDNESS GLOBALLY. IN A CONSERVATIVE ESTIMATE, CORNEAL DISEASES AFFECT NEARLY 300,000 PEOPLE IN THE UNITED STATES, WITH FUCHS’ DYSTROPHY AFFECTING 4% OF PEOPLE AGED OVER 40. GIVEN THE LARGE PREVALENCE OF CORNEAL DISEASE AND THE NEAR-IMPOSSIBILITY OF PERFORMING BIOPSY, HIGH-DEFINITION CORNEAL IMAGING IS NEEDED TO ASSIST CLINICAL DIAGNOSIS, EVALUATE PROGRESSION OF DISEASES, AND TREATMENT. ADDITIONALLY, THE CORNEA IS THE MOST COMMONLY TRANSPLANTED TISSUE WORLDWIDE. GABOR-DOMAIN OPTICAL COHERENCE MICROSCOPY (GDOCM) IS A HIGH-RESOLUTION, NON-INVASIVE IMAGING TECHNOLOGY THAT CAN VISUALIZE MICROSCOPIC STRUCTURES IN VIVO IN 3D. PRELIMINARY DATA SUGGEST THAT GDOCM HAS THE FOLLOWING KEY ADVANTAGES OVER EXISTING CORNEAL IMAGING TECHNIQUES, WHICH INCLUDE SPECULAR AND CONFOCAL MICROSCOPY: 1) 10-100X INCREASE IN FIELD OF VIEW – THIS WILL LEAD TO MORE ACCURATE QUALIFICATION OF THE CORNEAL TISSUE, SINCE A LARGER AREA CAN BE ASSESSED; 2) SIMULTANEOUS MEASURE OF CORNEAL THICKNESS, QUANTIFICATION OF ENDOTHELIAL CELL DENSITY, AS WELL AS IDENTIFICATION OF MORPHOLOGICAL VARIATIONS DUE TO CORNEAL DISEASE – THIS WILL LEAD TO FULL CORNEAL EVALUATION IN ONE INSTRUMENT; 3) 3D IMAGING CAPABILITY AT THE CELLULAR LEVEL OF THE MOSAIC OF TRANSLUCENT CORNEAL CELLS – THIS WILL ENABLE A DETAILED UNDERSTANDING THE VOLUMETRIC PROGRESSION OF THE DISEASES. WE HAVE ASSEMBLED AN EXCEPTIONALLY STRONG TEAM OF CLINICAL INVESTIGATORS TO COLLABORATE ON THIS PROPOSAL, AND WITH THEIR HELP WE HAVE IDENTIFIED FOUR USE CASES FOR CLINICAL APPLICATION OF OUR DUAL-IMAGING TECHNOLOGY TO IMAGE THE CORNEA WITH VOLUMETRIC CELLULAR-RESOLUTION. WE ENVISION THAT IN THE FUTURE THE DUAL OCT (OPTICAL COHERENCE TOMOGRAPHY) AND GDOCM INSTRUMENT ENABLED BY THIS PHASE II SBIR PROPOSAL WILL PROVIDE AN IMAGE-GUIDANCE METHOD TO ASSIST CLINICIANS IN THE ASSESSMENT AND TREATMENT OF CORNEAL DISEASES AND OTHER DISEASES AFFECTING THE ANTERIOR SEGMENT OF THE EYE, INCLUDING DIABETES AND GLAUCOMA.

WATER, SANITATION, HEALTHCARE, NUTRITION, SHELTER, GENDER-BASED VIOLENCE AND CONSTRUCTION SERVICES IN GIHMBE, KIZIBA AND NYABIHEKE REFUGEE CAMPS.

AWARD TO SUPPORT THE DEVELOPMENT OF A CUSTOMER FEEDBACK SUPPORT MECHANISM.

TO PROVIDE HEALTH AND WATER, SANITATION, AND HYGIENE SERVICES IN RESPONSE TO COVID-19 EMERGENCY IN SUDAN.

THE NEW DIRECTIONS PROJECT

PURPOSE: THE CONTINUUM OF CARE (COC) PROGRAM IS DESIGNED TO PROMOTE COMMUNITY-WIDE COMMITMENT TO THE GOAL OF ENDING HOMELESSNESS; PROVIDE FUNDING FOR EFFORTS BY NONPROFIT PROVIDERS, STATES, AND LOCAL GOVERNMENTS TO QUICKLY HOUSE HOMELESS INDIVIDUALS AND FAMILIES WHILE MINIMIZING THE TRAUMA AND DISLOCATION CAUSED TO HOMELESS INDIVIDUALS, FAMILIES, AND COMMUNITIES BY HOMELESSNESS; PROMOTE ACCESS TO AND EFFECTIVE UTILIZATION OF MAINSTREAM PROGRAMS BY HOMELESS INDIVIDUALS AND FAMILIES; AND OPTIMIZE SELF-SUFFICIENCY AMONG INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS. THE MOST RECENT COC AWARD ANNOUNCEMENT LISTING AWARDS BY STATE AND COC IS ACCESSIBLE AT HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/COC/AWARDS. SELECT THE LINK UNDER THE FUNDING AND AWARD INFORMATION SECTION FOR THE APPROPRIATE FISCAL YEAR.; ACTIVITIES TO BE PERFORMED: CONTINUUM OF CARE PROGRAM FUNDS MAY BE USED TO PAY FOR THE ELIGIBLE COSTS USED TO ESTABLISH AND OPERATE PROJECTS UNDER FIVE PROGRAM COMPONENTS: (1) PERMANENT HOUSING, WHICH INCLUDES PERMANENT SUPPORTIVE HOUSING FOR PERSONS WITH DISABILITIES, AND RAPID REHOUSING; (2) TRANSITIONAL HOUSING; (3) SUPPORTIVE SERVICES ONLY; (4) HOMELESS MANAGEMENT INFORMATION SYSTEMS (HMIS), AND (5) IN SOME CASES, HOMELESSNESS PREVENTION. THIRTEEN TYPES OF ASSISTANCE MAY BE PROVIDED THROUGH THE CONTINUUM OF CARE (COC) PROGRAM: (1) COC PLANNING ACTIVITIES/COSTS FOR DESIGNING AND CARRYING OUT A COLLABORATIVE PROCESS FOR THE DEVELOPMENT OF AN APPLICATION TO HUD; (2) UNITED FUNDING AGENCY (UFA) COSTS FOR FISCAL CONTROL AND ACCOUNTING NECESSARY TO ASSURE THE PROPER DISBURSAL OF, AND ACCOUNTING FOR, FEDERAL FUNDS AWARDED TO SUBRECIPIENTS UNDER THE CONTINUUM OF CARE PROGRAM, (3) ACQUISITION OF REAL PROPERTY (INCLUDING STRUCTURES) FOR USE IN THE PROVISION OF HOUSING OR SUPPORTIVE SERVICES; (4) REHABILITATION OF STRUCTURES TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (5) NEW CONSTRUCTION, INCLUDING THE BUILDING OF A NEW STRUCTURE OR BUILDING AN ADDITION TO AN EXISTING STRUCTURE FOR USE AS SUPPORTIVE HOUSING; (6) LEASING OF A STRUCTURE OR STRUCTURES, OR PORTIONS THEREOF, TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (7) RENTAL ASSISTANCE, WHICH MAY BE SHORT-TERM, MEDIUM-TERM, OR LONG-TERM, AS WELL AS TENANT-BASED, PROJECT-BASED, OR SPONSOR-BASED, FOR TRANSITIONAL OR PERMANENT HOUSING; (8) SUPPORTIVE SERVICES TO ASSIST PROGRAM PARTICIPANTS OBTAIN AND MAINTAIN HOUSING; (9) OPERATING COSTS OF SUPPORTIVE HOUSING; (10) COSTS OF IMPLEMENTING AND OPERATING HMIS; (11) PROJECT ADMINISTRATIVE COSTS; (12) RELOCATION COSTS; AND (13) INDIRECT COSTS IN ACCORDANCE WITH 2 CFR PARTS 200, AS APPLICABLE. IN ADDITION TO USING GRANT FUNDS FOR THE ELIGIBLE COSTS DESCRIBED ABOVE, RECIPIENTS AND SUBRECIPIENTS IN CONTINUUMS OF CARE DESIGNATED AS HIGH PERFORMING COMMUNITIES MAY ALSO USE GRANT FUNDS TO PROVIDE HOUSING RELOCATION AND STABILIZATION SERVICES AND SHORT- AND/OR MEDIUM-TERM RENTAL ASSISTANCE TO INDIVIDUALS AND FAMILIES AT RISK OF HOMELESSNESS AS SET FORTH IN 24 CFR 576.103 AND 24 CFR 576.104, IF NECESSARY TO PREVENT THE INDIVIDUAL OR FAMILY FROM BECOMING HOMELESS. LIMITATION ON USE OF FUNDS: NO ASSISTANCE PROVIDED UNDER PROGRAM (OR ANY STATE OR LOCAL GOVERNMENT FUNDS USED TO SUPPLEMENT THIS ASSISTANCE) MAY BE USED TO REPLACE STATE OR LOCAL FUNDS PREVIOUSLY USED, OR DESIGNATED FOR USE, TO ASSIST HOMELESS PERSONS OR PERSONS AT-RISK OF HOMELESSNESS.; EXPECTED OUTCOMES: DECREASE IN THE NUMBER INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS, MORE SPECIFICALLY USING PERFORMANCE INDICATORS SUCH AS THE LENGTH OF TIME HOMELESS, RETURNS TO HOMELESSNESS OVER TIME, AND EXITS TO PERMANENT HOUSING. COC PERFORMANCE PROFILE REPORTS CAN BE FOUND AT HTTPS://WWW.HUDEXCHANGE.INFO/PROGRAMS/COC/COC-PERFORMANCE-PROFILE-REPORTS/.; INTENDED BENEFICIARIES: INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

PORT SECURITY GRANT PROGRAM

ENGAGES AMERICORPS MEMBERS IN FULL AND PART-TIME SERVICE TO MEET COMMUNITY NEEDS IN EDUCATION, THE ENVIRONMENT, HEALTH, VETERANS, AND OTHER AREAS

TO IMPROVE HEALTH AND WELLBEING OF CONGOLESE AND BURUNDIAN REFUGEES LIVING IN THREE CAMPS. AND TARGETED HOST COMMUNITIES. IN RWANDA

TAS::89 0321::TAS CITY OF LANSING BOARD OF WATER AND LIGHT CDP FOR PLUG-IN HYBRID INITIATIVE.

ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING, AND MISCELLANEOUS GRANTS

TO PROVIDE PROTECTION AND WASH SERVICES IN SOUTH SUDAN.

LIGHTHOUSE SKILLS FOR YOUNG FATHERS PROGRAM

THIS EDA INVESTMENT SUPPORTS THE GREENEVILLE WATER AND LIGHT COMMISSION OF THE TOWN OF GREENEVILLE D/B/A GREENEVILLE WATER COMMISSION WITH MAKING SEWER INFRASTRUCTURE IMPROVEMENTS TO THE HOLLEY CREEK BASIN WITHIN THE TOWN TO SERVE PARKWAY PRODUCTS IN GREENE COUNTY, TENNESSEE. THE PROJECT WILL PROVIDE FOR FUTURE GROWTH IN INDUSTRY FOR GREENEVILLE AND HELP OFFSET JOB LOSSES DUE TO COAL TRANSPORTATION REDUCTIONS ON A NEARBY CSX RAIL YARD. ONCE COMPLETED, THE PROJECT WILL SERVE AS A CATALYST FOR ECONOMIC DEVELOPMENT, STIMULATE THE LOCAL ECONOMY, SAVE JOBS, AND HELP CREATE NEW JOB OPPORTUNITIES THROUGHOUT THE REGION.

STARTALK RADIO SHOW

AURORA FLIGHT SCIENCES, A BOEING COMPANY, IS COLLABORATING WITH BOEING RESEARCH AND TECHNOLOGY, THE UNIVERSITY OF CALIFORNIA SAN DIEGO, THE UNIVERSITY OF SOUTH CAROLINA, AND STORAGENERGY TECHNOLOGIES TO DEVELOP AN INNOVATIVE ALUMINUM (AL) AIR ENERGY STORAGE AND POWER GENERATION (ESPG) SYSTEM. THIS SYSTEM AIMS TO MEET THE ZERO-EMISSION, 1000 WH/KG, 1000 WH/L, AND >70% ENERGY EFFICIENCY TARGETS SET BY ARPA-E PROPEL 1K. BY COMBINING HIGH-ENERGY DENSITY AL FUEL WITH EFFICIENT ENERGY EXTRACTION AND CONVERSION, THE SYSTEM ENABLES ELECTRIFICATION ACROSS THE AVIATION, RAILROAD, MARITIME, AND TRUCKING INDUSTRIES. THE TEAM WILL DEVELOP A PROTOTYPE WITH A MINIMUM CAPACITY OF = 1KWH TO PROVE THE CONCEPT AND DEMONSTRATE PERFORMANCE. THE SYSTEM UTILIZES A PLATFORM THAT SEPARATES ENERGY AND POWER, ALLOWING FOR SWAPPABLE ENERGY BOXES THAT CAN BE RAPIDLY AND SEAMLESSLY CHARGED AND DISCHARGED MECHANICALLY FROM THE VEHICLE. SAFETY IS ENSURED BY USING NON-FLAMMABLE AND NON-TOXIC MEDIA. WITH ITS HIGH ENERGY EFFICIENCY, THE SYSTEM EFFECTIVELY CONVERTS STORED ENERGY INTO USABLE POWER, REDUCING WASTE AND IMPROVING OVERALL PERFORMANCE. THE SYSTEM'S VERSATILITY AND ADAPTABILITY MAKE IT SUITABLE FOR VARIOUS TRANSPORTATION APPLICATIONS, WHILE ITS COMPACT AND LIGHTWEIGHT DESIGN FACILITATES SEAMLESS INTEGRATION INTO DIFFERENT VEHICLE PLATFORMS. BY ADOPTING THIS SYSTEM, ELECTRIFICATION OF TRANSPORTATION CAN LEAD TO SIGNIFICANT REDUCTIONS IN GREENHOUSE GAS EMISSIONS, AIR POLLUTION, AND DEPENDENCE ON FOSSIL FUELS. IN SUMMARY, THE AL-AIR ESPG SYSTEM PROVIDES A SUSTAINABLE AND ENVIRONMENTALLY FRIENDLY SOLUTION FOR POWERING HEAVY-DUTY TRANSPORTATION, POSING IMMENSE POTENTIAL FOR ELECTRIFYING TRANSPORTATION AND ADVANCING TOWARDS A CLEANER, MORE SUSTAINABLE FUTURE.

CONTINUUM OF CARE PROGRAM

PORT SECURITY GRANT PROGRAM

TO ENSURE ACCESS TO QUALITY PROTECTION AND MULTI-SECTORAL ASSISTANCE SERVICES

FOSTERING RESILIENCE AND PROTECTIVE ENVIRONMENTS TO IMPROVE HEALTH AND WELL BEING

GENDER-BASED VIOLENCE COOPERATIVE AGREEMENT

LOW COST CONCENTRATED SOLAR POWER (CSP) COLLECTOR

PURPOSE: THE CONTINUUM OF CARE (COC) PROGRAM IS DESIGNED TO PROMOTE COMMUNITY-WIDE COMMITMENT TO THE GOAL OF ENDING HOMELESSNESS; PROVIDE FUNDING FOR EFFORTS BY NONPROFIT PROVIDERS, STATES, AND LOCAL GOVERNMENTS TO QUICKLY HOUSE HOMELESS INDIVIDUALS AND FAMILIES WHILE MINIMIZING THE TRAUMA AND DISLOCATION CAUSED TO HOMELESS INDIVIDUALS, FAMILIES, AND COMMUNITIES BY HOMELESSNESS; PROMOTE ACCESS TO AND EFFECTIVE UTILIZATION OF MAINSTREAM PROGRAMS BY HOMELESS INDIVIDUALS AND FAMILIES; AND OPTIMIZE SELF-SUFFICIENCY AMONG INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS. THE MOST RECENT COC AWARD ANNOUNCEMENT LISTING AWARDS BY STATE AND COC IS ACCESSIBLE AT HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/COC/AWARDS. SELECT THE LINK UNDER THE FUNDING AND AWARD INFORMATION SECTION FOR THE APPROPRIATE FISCAL YEAR.; ACTIVITIES TO BE PERFORMED: CONTINUUM OF CARE PROGRAM FUNDS MAY BE USED TO PAY FOR THE ELIGIBLE COSTS USED TO ESTABLISH AND OPERATE PROJECTS UNDER FIVE PROGRAM COMPONENTS: (1) PERMANENT HOUSING, WHICH INCLUDES PERMANENT SUPPORTIVE HOUSING FOR PERSONS WITH DISABILITIES, AND RAPID REHOUSING; (2) TRANSITIONAL HOUSING; (3) SUPPORTIVE SERVICES ONLY; (4) HOMELESS MANAGEMENT INFORMATION SYSTEMS (HMIS), AND (5) IN SOME CASES, HOMELESSNESS PREVENTION. THIRTEEN TYPES OF ASSISTANCE MAY BE PROVIDED THROUGH THE CONTINUUM OF CARE (COC) PROGRAM: (1) COC PLANNING ACTIVITIES/COSTS FOR DESIGNING AND CARRYING OUT A COLLABORATIVE PROCESS FOR THE DEVELOPMENT OF AN APPLICATION TO HUD; (2) UNITED FUNDING AGENCY (UFA) COSTS FOR FISCAL CONTROL AND ACCOUNTING NECESSARY TO ASSURE THE PROPER DISBURSAL OF, AND ACCOUNTING FOR, FEDERAL FUNDS AWARDED TO SUBRECIPIENTS UNDER THE CONTINUUM OF CARE PROGRAM, (3) ACQUISITION OF REAL PROPERTY (INCLUDING STRUCTURES) FOR USE IN THE PROVISION OF HOUSING OR SUPPORTIVE SERVICES; (4) REHABILITATION OF STRUCTURES TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (5) NEW CONSTRUCTION, INCLUDING THE BUILDING OF A NEW STRUCTURE OR BUILDING AN ADDITION TO AN EXISTING STRUCTURE FOR USE AS SUPPORTIVE HOUSING; (6) LEASING OF A STRUCTURE OR STRUCTURES, OR PORTIONS THEREOF, TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (7) RENTAL ASSISTANCE, WHICH MAY BE SHORT-TERM, MEDIUM-TERM, OR LONG-TERM, AS WELL AS TENANT-BASED, PROJECT-BASED, OR SPONSOR-BASED, FOR TRANSITIONAL OR PERMANENT HOUSING; (8) SUPPORTIVE SERVICES TO ASSIST PROGRAM PARTICIPANTS OBTAIN AND MAINTAIN HOUSING; (9) OPERATING COSTS OF SUPPORTIVE HOUSING; (10) COSTS OF IMPLEMENTING AND OPERATING HMIS; (11) PROJECT ADMINISTRATIVE COSTS; (12) RELOCATION COSTS; AND (13) INDIRECT COSTS IN ACCORDANCE WITH 2 CFR PARTS 200, AS APPLICABLE. IN ADDITION TO USING GRANT FUNDS FOR THE ELIGIBLE COSTS DESCRIBED ABOVE, RECIPIENTS AND SUBRECIPIENTS IN CONTINUUMS OF CARE DESIGNATED AS HIGH PERFORMING COMMUNITIES MAY ALSO USE GRANT FUNDS TO PROVIDE HOUSING RELOCATION AND STABILIZATION SERVICES AND SHORT- AND/OR MEDIUM-TERM RENTAL ASSISTANCE TO INDIVIDUALS AND FAMILIES AT RISK OF HOMELESSNESS AS SET FORTH IN 24 CFR 576.103 AND 24 CFR 576.104, IF NECESSARY TO PREVENT THE INDIVIDUAL OR FAMILY FROM BECOMING HOMELESS. LIMITATION ON USE OF FUNDS: NO ASSISTANCE PROVIDED UNDER PROGRAM (OR ANY STATE OR LOCAL GOVERNMENT FUNDS USED TO SUPPLEMENT THIS ASSISTANCE) MAY BE USED TO REPLACE STATE OR LOCAL FUNDS PREVIOUSLY USED, OR DESIGNATED FOR USE, TO ASSIST HOMELESS PERSONS OR PERSONS AT-RISK OF HOMELESSNESS.; EXPECTED OUTCOMES: DECREASE IN THE NUMBER INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS, MORE SPECIFICALLY USING PERFORMANCE INDICATORS SUCH AS THE LENGTH OF TIME HOMELESS, RETURNS TO HOMELESSNESS OVER TIME, AND EXITS TO PERMANENT HOUSING. COC PERFORMANCE PROFILE REPORTS CAN BE FOUND AT HTTPS://WWW.HUDEXCHANGE.INFO/PROGRAMS/COC/COC-PERFORMANCE-PROFILE-REPORTS/.; INTENDED BENEFICIARIES: INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

MULTIMODAL INTRAORAL CAMERA - ABSTRACT THE WHO GLOBAL ORAL HEALTH STATUS REPORT (2022) ESTIMATED THAT ORAL DISEASES AFFECT CLOSE TO $3.5 BILLION PEOPLE WORLDWIDE. DENTAL CARIES AND CRACKS ARE TWO COMMON DENTAL DISEASES. GLOBALLY, AN ESTIMATED $2 BILLION PEOPLE SUFFER FROM CARIES OF PERMANENT TEETH AND $514 MILLION CHILDREN SUFFER FROM CARIES OF PRIMARY TEETH. CRACKED TOOTH IS A COMMON DENTAL HARD TISSUE DISEASE AND IS THE THIRD MAJOR CAUSE OF TOOTH LOSS AFTER CARIES AND PERIODONTAL DISEASE. WHILE THERE ARE SOME ADJUNCTS BASED ON AUTOFLUORESCENCE AND TRANSILLUMINATION FOR DETECTING CARIES AND CRACK, NONE OF THEM CAN PROVIDE QUANTITATIVE AND INTERNAL TOOTH STRUCTURAL INFORMATION FOR ACCURATE DIAGNOSIS AND MONITORING TREATMENT PROGRESS. TO ADDRESS THE NEED OF A QUANTITATIVE DEVICE FOR EARLIER DETECTION AND MORE ACCURATE DIAGNOSIS OF CARIES AND CRACK, LIGHT RESEARCH INC (LRI) PROPOSES TO OPTIMIZE AND COMMERCIALIZE A COMPACT MULTIMODAL INTRAORAL CAMERA WHICH UNIQUELY INTEGRATES POLARIZED WHITE LIGHT IMAGING (PWLI), AUTOFLUORESCENCE IMAGING (AFI), OPTICAL COHERENCE TOMOGRAPHY (OCT) IMAGING, AND NOVEL NIR TRANSILLUMINATION IMAGING (NIR-TI) MODALITIES. FOUR IMAGING MODALITIES WITH DISTINCT AND COMPLEMENTARY CONTRAST MECHANISMS WILL IMPROVE THE SENSITIVITY AND SPECIFICITY IN DETECTING CARIES AND CRACK SIGNIFICANTLY. THE NOVEL SYSTEM DESIGN FACILITATES THE COMPACT INTEGRATION OF FOUR DIFFERENT IMAGING MODALITIES AND ENABLES THE SEAMLESS TRANSITION BETWEEN IMAGING MODALITIES. THE PROPOSED CAMERA IS CLINICALLY INNOVATIVE IN THAT IT WILL SCREEN THE TOOTH IN WIDE FIELD OF VIEW (FOV) IMAGING MODES (PWLI, AFI, AND/OR NIR-TI) TO DETECT AND SEGMENT SUSPICIOUS REGION, AND THEN GUIDE OCT SCAN TO OBTAIN INTERNAL TOOTH STRUCTURAL INFORMATION OF THE SUSPICIOUS REGION FOR ACCURATE DIAGNOSIS. EARLIER CARIES AND CRACK DETECTION WILL ENABLE THE DENTAL PRACTITIONER TO INITIATE EARLY PROPHYLACTIC TREATMENT, THE INTERNAL TOOTH STRUCTURAL INFORMATION FROM OCT IMAGE AND THE REGISTERED WIDE-FOV PWLI AND AFI IMAGES WILL FACILITATE THE MONITORING OF TREATMENT PROGRESS. TO ACHIEVE THE PROJECT GOAL, LRI HAS ASSEMBLED A MULTIDISCIPLINARY TEAM WITH EXPERTISE IN DEVELOPING (DR. WILDER-SMITH) AND VALIDATING (DR. AMAECHI) OPTICAL TECHNOLOGIES FOR ORAL DISEASES INCLUDING CARIES AND CRACK, DEVELOPING COMMERCIAL DENTAL PRODUCTS (DR. LIANG), AND DEVELOPING ADVANCED IMAGE PROCESSING (DR. SONG). THE PROJECT TEAM MEMBERS HAVE COLLABORATIVELY OR INDEPENDENTLY INVESTIGATED DIFFERENT IMAGING MODALITIES FOR CARIES AND CRACK DETECTION, AS WELL AS FOR ORAL CANCER DETECTION AND DIAGNOSIS. IN THIS PROJECT, THE TEAM WILL FIRST OPTIMIZE AND PROTOTYPE TWO COMPACT MULTIMODAL INTRAORAL CAMERAS AND DEVELOP DEEP LEARNING-BASED IMAGE SEGMENTATION ALGORITHMS (AIM 1), OPTIMIZE SYSTEM SETTINGS AND EVALUATE THE PROPOSED MULTIMODAL INTRAORAL CAMERA (AIM 2), AND THEN CONDUCT A PILOT CLINICAL STUDY TO EVALUATE PERFORMANCE OF THE MULTIMODAL INTRAORAL CAMERA IN DETECTING CARIES AND CRACKS IN HUMAN SUBJECTS (AIM 3).

SBIR PHASE II: RELIABLE, SCALABLE PROJECTION MAPPING SYSTEMS WITH REUSABLE CONTENT

VA IS PROVIDING PER DIEM FUNDING TO ASSIST WITH THE OPERATIONAL COSTS ASSOCIATED WITH TRANSITIONAL HOUSING BEDS FOR HOMELESS VETERANS.

ALMMII - PILOT DOD MENTOR PROTEGE PROGRAM-MANUFACTURING INNOVATION INSTITUTE (MPP-MII) PARTNERSHIP INITIATIVE

VA IS PROVIDING PER DIEM FUNDING TO ASSIST WITH THE OPERATIONAL COSTS ASSOCIATED WITH TRANSITIONAL HOUSING BEDS FOR HOMELESS VETERANS.

ENERGY-EFFICIENT DATA CENTERS AND HIGH-PERFORMANCE COMPUTING ENABLED BY ON-CHIP PRINTED MICROELECTRONIC OPTICAL COMPONENT AND CIRCUIT MANUFACTURING

FINANCIAL ASSISTANCE AWARD

TAS::89 0328::TAS RECOVERY ACT. OBLIGATE FY 10 ARRA FUNDING IN THE AMOUNT OF $1,346,175.00

COOPERATIVE AGREEMENT TO SUPPORT NAVIGATORS IN FEDERALLY-FACILITATED AND STATE PARTNERSHIP MARKETPLACES

YOUTH - YOUNG OFFENDER

IMPROVED HEALTH AND WELL-BEING OF CONFLICT-AFFECTED POPULATIONS

DEVELOPMENT OF A NOVEL MRI CONTRAST AGENT FOR EARLY DETECTION OF ALCOHOLIC STEATOHEPATITIS

ULTRAHIGH RATE FABRICATION OF THIN-FILM SILICON SOLAR CELLS USING ROLL-TO-ROLL HYBRID CVD TECHNOLOGIES WITH RTSE MONITORING AND CONTROL