Sequoia Foundation

ENHANCING THE CALIFORNIA ENVIRONMENTAL CONTAMINANT BIOMONITORING PROGRAM

DEVELOPMENT OF A RESEARCH-READY PREGNANCY AND NEWBORN BIOBANK IN CALIFORNIA

EXPANDING CALIFORNIA BIOMONITORING DATABASE THROUGH STATEWIDE SURVEILLANCE AND TARGETED POPULATION STUDIES

CALIFORNIA'S CHILDHOOD LEAD POISONING PREVENTION PROGRAM

EXPANDING CALIFORNIA BIOMONITORING DATABASE THROUGH STATEWIDE SURVEILLANCE AND TARGETED POPULATION STUDIES

PURPOSE: THE LEAD-BASED PAINT HAZARD REDUCTION (LHR) GRANT PROGRAM IS TO MAXIMIZE THE NUMBER OF CHILDREN UNDER THE AGE OF SIX PROTECTED FROM LEAD POISONING BY ASSISTING STATES, CITIES, COUNTIES/PARISHES, NATIVE AMERICAN TRIBES OR OTHER UNITS OF LOCAL GOVERNMENT IN UNDERTAKING COMPREHENSIVE PROGRAMS TO IDENTIFY AND CONTROL LEAD-BASED PAINT HAZARDS IN ELIGIBLE PRIVATELY-OWNED RENTAL OR OWNER-OCCUPIED HOUSING POPULATIONS. IN ADDITION, THERE IS HEALTHY HOMES SUPPLEMENTAL FUNDING AVAILABLE THAT IS INTENDED TO ENHANCE THE LEAD-BASED PAINT HAZARD CONTROL ACTIVITIES BY COMPREHENSIVELY IDENTIFYING AND ADDRESSING OTHER HOUSING HAZARDS THAT AFFECT OCCUPANT HEALTH. INFORMATION ABOUT WHERE THE SUPPLEMENTAL FUNDING CAN BE USED CAN BE FOUND AT. HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/HEALTHY_HOMES/PROJECT_DESCRIPTIONS; ACTIVITIES TO BE PERFORMED: PROGRAM FUNDS WILL BE AWARDED TO APPLICANTS TO ACCOMPLISH THE FOLLOWING OBJECTIVES: A. TARGETED UNITS: TARGET LEAD HAZARD CONTROL EFFORTS IN HOUSING UNITS WHERE CHILDREN LESS THAN 6 YEARS OF AGE ARE AT GREATEST RISK OF LEAD POISONING (PRE-1960, AND, ESPECIALLY, PRE-1940 CONSTRUCTION), WHICH HAS HISTORICALLY INCLUDED CHILDREN IN LOW-INCOME AND MINORITY NEIGHBORHOODS, TO REDUCE THE LIKELIHOOD OF ELEVATED BLOOD LEAD LEVELS IN THESE CHILDREN. B. COST EFFECTIVENESS: UTILIZE COST-EFFECTIVE LEAD HAZARD CONTROL METHODS AND APPROACHES THAT ENSURE THE LONG-TERM SAFETY OF THE BUILDING OCCUPANTS. C. CAPACITY: BUILD LOCAL CAPACITY OF TRAINED AND CERTIFIED INDIVIDUALS AND FIRMS TO ADDRESS LEAD HAZARDS SAFELY AND EFFECTIVELY DURING LEAD HAZARD CONTROL, RENOVATION, REMODELING, AND MAINTENANCE ACTIVITIES. ANOTHER CORE ELEMENT FOR CAPACITY INCLUDES THE DEVELOPMENT OF COMPREHENSIVE, COMMUNITY-BASED APPROACHES TO INTEGRATING THIS GRANT PROGRAM WITHIN OTHER LOCAL INITIATIVES THROUGH PUBLIC AND PRIVATE PARTNERSHIPS THAT ADDRESS HOUSING RELATED HEALTH AND SAFETY HAZARDS AND/OR SERVE LOW-INCOME FAMILIES WITH CHILDREN UNDER THE AGE OF SIX (6). D. AFFIRMATIVE MARKETING: ESTABLISH AND IMPLEMENT A DETAILED PROCESS OF MONITORING AND ENSURING THAT UNITS MADE LEAD-SAFE ARE AFFIRMATIVELY MARKETED, AND PRIORITY GIVEN, TO FAMILIES WITH CHILDREN UNDER AGE 6 YEARS FOR NOT LESS THAN THREE YEARS. E. DATA COLLECTION: GATHER PRE- AND POST-TREATMENT DATA THAT SUPPORTS AND VALIDATES LEAD HAZARD CONTROL INVESTMENTS. PROGRAM DATA COLLECTED SHOULD SUPPORT THE EVALUATION OF GRANT PROGRAM ACTIVITIES AND OUTCOMES. F. TARGETED OUTREACH AND EDUCATION: CONDUCTING TARGETED OUTREACH, AFFIRMATIVE MARKETING, EDUCATION OR OUTREACH PROGRAMS ON LEAD HAZARD CONTROL AND LEAD POISONING PREVENTION DESIGNED TO INCREASE THE ABILITY OF THE APPLICANT TO DELIVER THE SPECIFIED LEAD HAZARD CONTROL SERVICES THROUGH THIS PROGRAM; INCLUDING EDUCATING OWNERS OF ELIGIBLE RENTAL PROPERTIES, TENANTS, AND OTHERS ON THE BENEFITS AND EXPECTATIONS OF PARTICIPATING IN THIS PROGRAM PROVIDED BY "TITLE X" OF THE RESIDENTIAL LEAD-BASED PAINT HAZARD REDUCTION ACT OF 1992.; EXPECTED OUTCOMES: TO IDENTIFY AND CLEAN UP DANGEROUS LEAD IN LOW-INCOME FAMILIES’ HOMES WHERE LOW-INCOME FAMILIES WERE CHILDREN 6 AND UNDER RESIDE. THESE INVESTMENTS WILL PROTECT FAMILIES AND CHILDREN BY TARGETING SIGNIFICANT LEAD AND HEALTH HAZARDS IN OVER 3,700 LOW-INCOME HOMES FOR WHICH OTHER RESOURCES ARE NOT AVAILABLE.; INTENDED BENEFICIARIES: TO ASSIST STATES, CITIES, COUNTIES/PARISHES, NATIVE AMERICAN TRIBES OR OTHER UNITS OF LOCAL GOVERNMENT IN UNDERTAKING COMPREHENSIVE PROGRAMS TO IDENTIFY AND CONTROL LEAD-BASED PAINT HAZARDS IN ELIGIBLE PRIVATELY-OWNED RENTAL OR OWNER-OCCUPIED HOUSING POPULATIONS WERE CHILDREN UNDER 6 RESIDE.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

MCH RESEARCH

ROLE OF PRE-NATAL VITAMIN D AND GENE INTERACTIONS IN AUTISM SPECTRUM DISORDERS; LEVERAGING AN EXISTING CASE-CONTROL STUDY

CHINA-CALIFORNIA ENVIRONMENTAL HEALTH TRAINING PROGRAM

HEALTHY HOMES AND LEAD POISONING PREVENTION PROGRAM

THE PREGNANCY EXPOSOME AND METABOLOME AND RISK FOR PREMENOPAUSAL BREAST CANCER - PROJECT SUMMARY/ABSTRACT PREMENOPAUSAL BREAST CANCER (PMBC), PARTICULARLY WHEN DIAGNOSED POSTPARTUM, IS INCREASING IN INCIDENCE AND IS OFTEN MORE AGGRESSIVE THAN BREAST CANCER DIAGNOSED LATER IN LIFE. ENVIRONMENTAL CHEMICAL EXPOSURES MAY INITIATE OR PROMOTE CARCINOGENESIS IN THE BREAST AND RISK MAY BE MODIFIED BY ENDOGENOUS METABOLIC PATHWAYS. PREGNANT INDIVIDUALS ARE ESPECIALLY SUSCEPTIBLE TO EFFECTS OF EXOGENOUS CHEMICALS DUE TO CHANGES IN SUBSTANCE METABOLISM, TRANSPORT, AND INTAKE, WHICH IS CRITICALLY IMPORTANT DURING HORMONE-INDUCED BREAST DIFFERENTIATION AND DEVELOPMENT. PREGNANT PEOPLE ARE EXPOSED TO A VAST MULTIPLICITY OF EXOGENOUS CHEMICALS THAT MAY ACT SYNERGISTICALLY ON LATER DISEASE RISK, HOWEVER LITTLE IS KNOWN ON HOW CHEMICAL EXPOSURES AND METABOLIC RESPONSES DURING THIS CRITICAL WINDOW AFFECT FUTURE PMBC RISK. RESEARCH AT THE EXPOSOME SCALE, WITH THE ABILITY TO COMPREHENSIVELY ACCOUNT FOR CO-POLLUTANT CONFOUNDING AND INVESTIGATE EXPANSIVE CHEMICAL MIXTURES, MAY REVEAL DISEASE RELATIONSHIPS UNDETECTABLE IN SINGLE-POLLUTANT OR LOWER-DIMENSIONAL APPROACHES. BIOLOGIC REACTIONS TO THESE CHEMICAL EXPOSURES, ALONG WITH NUMEROUS ENDOGENOUS PROCESSES THAT MODULATE BREAST CANCER RISK ARE ENCODED IN METABOLIC PATHWAYS, WHICH CHANGE SUBSTANTIALLY WITH BOTH PREGNANCY AND MENOPAUSE. METABOLOMIC PROFILING MAY YIELD IDENTIFICATION OF EARLY BIOLOGIC SIGNATURES OF PMBC RISK AS WELL AS INSIGHT INTO UNDERLYING MECHANISMS AND THE POTENTIAL DEVELOPMENT OF PREDICTIVE BIOMARKERS DURING PREGNANCY. THIS STUDY WILL BE THE FIRST TO JOINTLY ANALYZE THE UNTARGETED PREGNANCY EXPOSOME AND METABOLOME IN RELATION TO FUTURE PMBC RISK. USING PRENATAL SERUM SPECIMENS FROM AN ESTABLISHED, POPULATION-BASED CASE-COHORT OF OVER 3,000 WOMEN PREGNANT IN 2003-2019 IN CALIFORNIA (INCLUDING 1,283 PMBC CASES), HIGH-THROUGHPUT, ULTRA-HIGH RESOLUTION MASS SPECTROMETRY AND GAS AND LIQUID CHROMATOGRAPHY WILL QUANTIFY MORE THAN 600 ENVIRONMENTAL CHEMICALS AND OVER 1,000 METABOLITES PER SAMPLE. ADVANCED BIOINFORMATICS TOOLS SUCH AS HIGH-DIMENSIONAL MIXTURE MODELING, NETWORK ANALYSIS, AND MULTIOMICS DATA INTEGRATION TECHNIQUES WILL BE USED TO CHARACTERIZE EXPOSURE AND METABOLIC PROFILES, IDENTIFY SINGLE AND MULTIOMIC PATTERNS ASSOCIATED WITH PMBC RISK, AND UNCOVER MECHANISTIC PATHWAYS LINKING ENVIRONMENTAL EXPOSURES TO PMBC DEVELOPMENT. BY QUANTIFYING BOTH THE EXPOSOME AND METABOLOME WE CAN DETERMINE PMBC RISK IN RELATION TO COMPLEX PATTERNS OF REAL-WORLD ENVIRONMENTAL EXPOSURES; METABOLIC BIOMARKERS OF ENDOGENOUS BIOLOGICAL RISK; AND, CRUCIALLY, PATTERNS OF CROSS-OMICS INTERACTION. SUBTYPE-SPECIFIC ANALYSES WILL FOCUS ON MORE AGGRESSIVE FORMS OF EARLY BREAST CANCER, SUCH AS TRIPLE NEGATIVE TUMORS AND DIAGNOSES WITHIN FIVE OR TEN YEARS OF DELIVERY. BY CAPTURING COMPLEX INTERACTIONS BETWEEN EXPOSURES AND METABOLIC RESPONSES DURING PREGNANCY, THIS STUDY HAS THE POTENTIAL TO TRANSFORM UNDERSTANDING OF EARLY-LIFE BREAST CANCER RISK AND GUIDE NOVEL PREVENTION EFFORTS. FINDINGS FROM THIS WORK WILL FILL CRITICAL GAPS IN BREAST CANCER ETIOLOGY, IDENTIFY MODIFIABLE RISK FACTORS AND EARLY BIOLOGIC MARKERS, AND LAY GROUNDWORK FOR PREVENTION OR SCREENING STRATEGIES TAILORED TO PREGNANCY AND THE POSTPARTUM PERIOD.

DESCRIPTION:THE PURPOSE OF THIS AMERICAN RESCUE PLAN FUNDED AND COMPETITIVELY SELECTED COOPERATIVE AGREEMENT IS TO CONDUCT AMBIENT AIR MONITORING OF POLLUTANTS OF GREATEST CONCERN IN COMMUNITIES WITH ENVIRONMENTAL AND HEALTH OUTCOME DISPARITIES STEMMING FROM POLLUTION AND THE COVID-19 PANDEMIC. THIS AGREEMENT PROVIDES FULL FEDERAL FUNDING IN THE AMOUNT OF $499,895.ACTIVITIES:THESE FUNDS WILL BE USED TO SUPPORT COMMUNITY AND LOCAL EFFORTS TO MONITOR THEIR OWN AIR QUALITY AND TO PROMOTE AIR QUALITY MONITORING PARTNERSHIPS BETWEEN COMMUNITIES AND TRIBAL, STATE, AND LOCAL GOVERNMENTS THAT: LEVERAGE EXISTING AIR QUALITY EXPERTISE, EXPAND USE OF COMMUNITY MONITORING GROUPS AND OTHER APPROACHES THAT GIVE THE COMMUNITY A VOICE IN THE MONITORING OF THE AIR QUALITY, AND BUILD A FOUNDATION OF TRUSTING RELATIONSHIPS AND ENHANCED UNDERSTANDING FROM WHICH SUSTAINABLE SOLUTIONS TO COMMUNITY AIR POLLUTION PROBLEMS CAN BE FOUND. SPECIFICALLY, THE RECIPIENT WILL: CREATE A REGIONAL, RESOURCE-EFFICIENT COLLABORATION OF COMMUNITY-BASED ORGANIZATIONS, GOVERNMENT COLLABORATORS, DATA ANALYSIS STAKEHOLDERS, AND TECHNOLOGY PARTNERS IN THE CALIFORNIA BAY AREA THAT WILL UNDERTAKE 1) COMMUNITY ENGAGEMENT AND COMMUNITY-SPECIFIC NEEDS-ASSESSMENT ACTIVITIES, 2) SUPPORT AIR QUALITY CAPACITY-BUILDING, 3) DEPLOY A PUBLIC NETWORK OF LOW-COST AIR SENSORS THROUGHOUT THREE CALIFORNIA BAY AREA ENVIRONMENTAL JUSTICE COMMUNITIES (EASTERN SAN FRANCISCO, EAST OAKLAND AND SOUTH SAN FRANCISCO), AND 4) PROMOTE BEST PRACTICES IN COMMUNITY AIR MONITORING DERIVED FROM OUR ACTIVITIES.SUBRECIPIENT:COMMUNITY-BASED PARTNERS THAT RECEIVE SUBAWARDS WILL LEVERAGE COMMUNITY CONNECTIONS TO FURTHER THE OBJECTIVES LAID OUT IN THE WORKPLAN. INCLUDING, ENGAGING COMMUNITY IN DIALOGUE AROUND AIR QUALITY DATA AND DEPLOYMENT OF AIR QUALITY SENSORS.OUTCOMES:EXPECTED DELIVERABLES INCLUDE AIR SENSOR DATA TO PROVIDE QUANTIFIED INFORMATION TO INFORM A CALIFORNIA BAY AREA COMMUNITY AIR QUALITY COLLABORATIVE EFFORT. DIRECT BENEFICIARIES OF THESE ACTIVITIES ARE COMMUNITY RESIDENTS WHO WILL HAVE ACCESS TO COMMUNITY DRIVEN AIR QUALITY DATA IN ENVIRONMENTAL JUSTICE COMMUNITIES.

MULTIGENERATIONAL AIR POLLUTION EXPOSURE AND ADVERSE BIRTH OUTCOMES - PROJECT SUMMARY GROWING EVIDENCE SUGGESTS THAT PRENATAL ENVIRONMENTAL EXPOSURES PLAY A ROLE IN THE BIRTH OUTCOMES AND HEALTH OF FUTURE GENERATIONS. WHILE PREGNANCY EXPOSURE TO AMBIENT AIR POLLUTION IS RELATED TO INCREASED RISK OF ADVERSE BIRTH OUTCOMES, NO STUDIES IN HUMAN POPULATIONS HAVE YET ESTIMATED THE IMPACT ON THE SUBSEQUENT GENERATION’S BIRTH OUTCOMES. OUR LONG-TERM GOAL IS TO UNDERSTAND THE MULTIGENERATIONAL IMPACT OF DIFFERENTIAL PREGNANCY EXPOSURE TO AIR POLLUTION ON FUTURE GENERATION BIRTH OUTCOMES. BLACK WOMEN AND WOMEN WITH LOWER SOCIOECONOMIC STATUS IN THE U.S. HAVE PERSISTENT HIGHER PREVALENCE OF ADVERSE BIRTH OUTCOMES, AND INDIVIDUALS BORN PRETERM OR TERM-LOW BIRTH WEIGHT HAVE COMPROMISED HEALTH ACROSS THE LIFE-COURSE. PREGNANCY EXPOSURE TO AIR POLLUTION IN A PRIOR GENERATION, ALONG WITH INCREASED SUSCEPTIBILITY EXPERIENCED BY DISADVANTAGED AND DIVERSE COMMUNITIES, MAY THEREFORE CONTRIBUTE TO OBSERVED BIRTH OUTCOME AND LIFETIME HEALTH DISPARITIES. USING THE LARGEST MULTIGENERATIONAL BIRTH COHORT IN THE U.S., THIS PROJECT AIMS TO: 1) QUANTIFY THE RELATIONSHIP BETWEEN FIRST GENERATION PREGNANCY EXPOSURE TO AIR POLLUTANTS (PARTICULATE MATTER [PM2.5] AND NITROGEN DIOXIDE [NO2]) AND ADVERSE BIRTH OUTCOMES OF THE THIRD GENERATION, AND 2) ESTIMATE THE CONTRIBUTION OF FIRST GENERATION PREGNANCY EXPOSURE TO AIR POLLUTION ON RACIAL/ETHNIC AND SOCIOECONOMIC DISPARITIES IN BIRTH OUTCOMES OF THE THIRD GENERATION. THE MULTIGENERATIONAL BIRTH COHORT CONSISTS OF NEARLY 700,000 CALIFORNIA BIRTHS WITH GEOCODED RESIDENCE INFORMATION FOR TWO GENERATIONS BORN 1982-2011. PREGNANCIES FROM EACH GENERATION WILL BE ASSIGNED RECENTLY-DEVELOPED HISTORIC PM2.5 AND NO2 CONCENTRATIONS, AND BIRTH DATA ENHANCED THROUGH LINKAGE TO PRENATAL AND NEWBORN SCREENING RECORDS AND CENSUS AND METEOROLOGICAL DATA. LONGITUDINAL MARGINAL MODELS WILL BE USED TO ASSESS THE DIRECT RELATION OF FIRST GENERATION PREGNANCY AIR POLLUTION EXPOSURE WITH PRETERM AND TERM- LOW BIRTH WEIGHT IN THE THIRD GENERATION. EQUITABLE EXPOSURE CONDITIONS WILL BE SIMULATED USING A STOCHASTIC INTERVENTION TO EVALUATE CHANGE IN RACIAL/ETHNIC AND SOCIOECONOMIC BIRTH OUTCOME DISPARITIES UNDER THE SCENARIO WHERE DISADVANTAGED GROUPS RECEIVE AN EXPOSURE DISTRIBUTION EQUAL TO THAT OF HIGHER SOCIOECONOMIC STATUS OR NON-HISPANIC WHITE CALIFORNIANS. THE PROPOSED RESEARCH IS SIGNIFICANT BECAUSE FINDINGS MAY UNCOVER ANOTHER PATHWAY BY WHICH AIR POLLUTION INFLUENCES HEALTH, AS WELL AS PREVIOUSLY UNMEASURED EXPOSURE BURDEN FROM PREGNANCY AIR POLLUTION EXPOSURE IN A PRIOR GENERATION. THE PROPOSED STUDY ALSO HAS IMPLICATIONS FOR DESIGNING PUBLIC HEALTH AND ENVIRONMENTAL JUSTICE INTERVENTIONS. BY CHARACTERIZING PRIOR GENERATION EXPOSURES IN THE CONTEXT OF RACIAL/ETHNIC AND SOCIOECONOMIC DISPARITIES, THE PROJECT PROVIDES METHODS TO ESTIMATE THE LONG-TERM IMPACT OF EXPOSURES AMONG VULNERABLE POPULATIONS. EXPANDING AIR POLLUTION HEALTH EFFECTS RESEARCH TO MULTIPLE GENERATIONS COULD, IN THE LONG TERM, INFORM CALCULATIONS OF HEALTH AND EQUITY BENEFITS RELATED TO AIR POLLUTION REDUCTIONS.

COLLABORATIVE RESEARCH: CALBUG AN INTERACTIVE DATABASE USING ARTHROPODS TO EXAMINE IMPACTS OF CLIMATE CHANGE AND HABITAT MODIFICATION

NEURO-DEVELOPMENTAL DISABILITIES SCREENING AND ASSESSMENT IN UGANDA

1/2 - PLANNING A REGIONAL CHINA GEOHEALTH HUB: U.S.

MCH RESEARCH

CALIFORNIA ASTHMA RESEARCH SUMMIT: A FOCUS ON HEALTH CARE DELIVERY AND REDUCING DISPARITIES.

THE OBJECTIVE OF THIS PROJECT IS TO DEVELOP AND INTEGRATE CURRICULUM FOR HIGH SCHOOL STUDENTS TO EXPLORE LOCAL EJ ISSUES, UNDERSTAND COMMUNITY HEALTH IMPACTS, AND ENGAGE LOCAL RESIDENTS AND LEADERS IN DEVELOPING SOLUTIONS TO PROTECT HEALTH. THE PROJECT WILL LEVERAGE A PREVIOUS AIR QUALITY PROJECT TO ASSESS AIR QUALITY ACROSS SAN LEANDRO; ASSESS LOCAL SURFACE WATER QUALITY AND DEVELOP POLLUTION PREVENTION STRATEGIES; ASSESS CHEMICAL EXPOSURE AND AIR QUALITY AT HOME, AND DEVELOP EXPOSURE REDUCTION STRATEGIES. THIS AGREEMENT PROVIDES FULL FEDERAL FUNDING IN THE AMOUNT OF $30,000. SEE TERMS AND CONDITIONS. PREAWARD COSTS HAVE BEEN APPROVED BACK TO OCTOBER 1, 2019.