Onea

DESCRIPTION:THIS AGREEMENT APPROVES FUNDING IN THE AMOUNT OF $2,650,770 UNDER THE INFRASTRUCTURE INVESTMENT AND JOBS ACT (IIJA) TO THE TOWN OF HONEA PATH SOUTH CAROLINA. BROWNFIELDS ARE REAL PROPERTY, THE EXPANSION, DEVELOPMENT OR REUSE OF WHICH MAY BE COMPLICATED BY THE PRESENCE OR POTENTIAL PRESENCE OF A HAZARDOUS SUBSTANCE, POLLUTANT, OR CONTAMINANT. THE RECIPIENT WILL CONDUCT REMEDIATION ACTIVITIES AS AUTHORIZED BY CERLCA 104(K)(3) IN THE TOWN OF HONEA PATH..ACTIVITIES:SPECIFICALLY, THIS AGREEMENT WILL PROVIDE FUNDING TO THE RECIPIENT TO CLEAN UP A BROWNFIELD SITE(S). ADDITIONALLY, THE RECIPIENT WILL COMPETITIVELY PROCURE (AS NEEDED) AND DIRECT A QUALIFIED ENVIRONMENTAL PROFESSIONAL TO CONDUCT ENVIRONMENTAL SITE ACTIVITIES, WILL CREATE A COMMUNITY INVOLVEMENT PLAN AND ADMINISTRATIVE RECORD FOR THE SITE(S), AND WILL REPORT ON INTERIM PROGRESS AND FINAL ACCOMPLISHMENTS BY COMPLETING AND SUBMITTING RELEVANT PORTIONS OF THE PROPERTY PROFILE FORM USING EPA'S ASSESSMENT, CLEANUP AND REDEVELOPMENT EXCHANGE SYSTEM (ACRES).SUBRECIPIENT:NO SUBAWARDS ARE INCLUDED IN THIS ASSISTANCE AGREEMENT.OUTCOMES:FURTHER, THE RECIPIENT WILL REMEDIATE 1 BROWNFIELD SITE AND ANTICIPATES HOLDING 3 COMMUNITY MEETINGS, FINALIZING 1 ANALYSIS OF BROWNFIELD CLEANUP ALTERNATIVES, AND SUBMITTING 16 QUARTERLY REPORTS. WORK CONDUCTED UNDER THIS AGREEMENT WILL BENEFIT THE RESIDENTS, BUSINESS OWNERS, AND STAKEHOLDERS IN AND NEAR THE TOWN OF HONEA PATH, SOUTH CAROLINA.

LIQUID-INFUSED TYMPANOSTOMY TUBES WITH NOVEL MATERIAL DESIGN FOR EFFICIENT DRUG TRANSPORT - PROJECT SUMMARY OTITIS MEDIA (OM) IS THE LEADING CAUSE OF HEALTHCARE VISITS IN THE WORLD, AFFECTING MORE THAN 700 MILLION PEOPLE WORLDWIDE1 AND ACCRUING A SIGNIFICANT ECONOMIC BURDEN OF OVER $5 BILLION ANNUALLY IN DIRECT AND INDIRECT COSTS IN THE US ALONE2. CHILDREN ARE PARTICULARLY SUSCEPTIBLE TO THIS DISEASE; 90% OF CHILDREN WILL CONTRACT OM BY THE AGE OF FIVE3,4, WITH 40% OF CASES EVENTUALLY BECOMING RECURRENT OR CHRONIC5. THE GOLD STANDARD FOR TREATMENT OF RECURRENT ACUTE OM AND CHRONIC OM WITH EFFUSION IS MYRINGOTOMY SURGERY WITH TYMPANOSTOMY TUBE INSERTION, IN WHICH A SMALL TUBE IS INSERTED INTO THE TYMPANIC MEMBRANE TO VENTILATE AND DRAIN FLUIDS OUT OF THE MIDDLE EAR. NEARLY 700,000 CHILDREN IN THE US ARE TREATED WITH TYMPANOSTOMY TUBES (TTS) ANNUALLY. TO HELP RESOLVE INFECTION AND PREVENT OTORRHEA, TUBE INSERTION IS COMMONLY SUPPLEMENTED WITH A REGIMEN OF TOPICAL ANTIBIOTICS. HOWEVER, DUE TO THEIR LUMEN GEOMETRY AND MATERIAL COMPOSITION, EXISTING TTS ARE NOT OPTIMIZED FOR RELIABLE DELIVERY OF DRUGS INTO THE MIDDLE EAR AND FREQUENTLY BECOME OCCLUDED BY CELLULAR DEBRIS, PATHOGENIC BACTERIA, BLOOD, AND PUS. SUCH CHALLENGES HINDER OM TREATMENT AND PROMPT INVASIVE TT REPLACEMENT SURGERIES IN UP TO 20% OF CHILDREN WITH TTS.6 TO COMBAT THESE CHALLENGES SIMULTANEOUSLY, PIONEAR TECHNOLOGIES INC. IS DEVELOPING TYMPANOSTOMY TUBES (PIONEAR TTS) WITH A PATENT-PENDING MATERIAL DESIGN THAT SYNERGISTICALLY REDUCES THE PRESSURE BARRIER FOR DRUGS TO PENETRATE INTO THE MIDDLE EAR AND SUPPRESSES BIOADHESION, THUS MAXIMIZING THE THERAPEUTIC BENEFIT OF TOPICAL DRUGS AND FACILITATING EARLIER ERADICATION OF INFECTION. NOVEL BIO-INSPIRED PIONEAR TTS POSSESS (1) PRECISELY ENGINEERED LUMEN GEOMETRY THAT IS OPTIMIZED TO PROMOTE SPONTANEOUS TRANSPORT OF THERAPEUTICS EVEN WITHOUT TRAGAL PUMPING, AND (2) SLIPPERY LIQUID-INFUSED MATERIALS THAT FURTHER MINIMIZE CONTACT LINE PINNING WHILE SUPPRESSING BIOADHESION7–9. PIONEAR TUBES ARE BIOCOMPATIBLE AND NON-OTOTOXIC, MINIMALLY INVASIVE, AND SIMPLE-TO-MANUFACTURE. THEY PRESERVE CRITICAL FUNCTIONALITY OF EXISTING TYMPANOSTOMY TUBES: TO ENABLE VENTILATION AND DRAINAGE OF THE MIDDLE EAR AND PREVENT WATER FROM ENTERING THE MIDDLE EAR.10,11 IN AN SBIR PHASE I, WE PROPOSE TO ASSESS THE IN VIVO PERFORMANCE OF PIONEAR TUBES FOR PROMOTING MORE EFFICIENT DRUG DELIVERY AND RESOLUTION OF OM COMPARED TO COMMERCIAL TUBES IN A GOLD-STANDARD OM CHINCHILLA MODEL. DEMONSTRATION OF PROOF-OF-CONCEPT WILL PREPARE THE TECHNOLOGY FOR SUCCESSFUL PHASE II APPLICATION AND FUTURE COMMERCIALIZATION. IF SUCCESSFUL, PIONEAR TTS WOULD ALLEVIATE THE PREVALENT ISSUE OF RECURRENT EAR INFECTIONS AND COMPLICATIONS, AND OPEN UP NEW AVENUES FOR THE TREATMENT OF OM. PIONEAR TECHNOLOGIES INC. WAS BORN OUT OF THREE YEARS OF RIGOROUS TRANSLATIONAL MEDICINE RESEARCH AND COLLABORATION BETWEEN HARVARD’S WYSS INSTITUTE, J.A. PAULSON SCHOOL OF ENGINEERING AND APPLIED SCIENCES, AND MASSACHUSETTS EYE AND EAR. ITS NOVEL TT TECHNOLOGY WAS AWARDED THE GRAND PRIZE AT THE COLLEGIATE INVENTORS COMPETITION BY NIHF AND USPTO AS WELL AS FIVE OTHER PRESTIGIOUS AWARDS.

THIS ACTION APPROVES AN AWARD IN THE AMOUNT OF $300,000 TO THE TOWN OF HONEA PATH, INC TO ENABLE THE TOWN TO CONDUCT COMMUNITY-WIDE ASSESSMENTS AT BROWNFIELDS SITES POTENTIALLY CONTAMINATED WITH HAZARDOUS SUBSTANCES AND/OR PETROLEUM PRODUCTS. THE RECIPIENT MAY ALSO DEVELOP A SITE INVENTORY, PRIORITIZE SITES AND CONDUCT PHASE I AND/OR PHASE II ASSESSMENTS. FUNDS MAY ALSO BE USED FOR PUBLIC OUTREACH, COMMUNITY INVOLVEMENT, AND CLEANUP/REUSE PLANNING ACTIVITIES.

MACHINE LEARNED BREATH SOUND SIGNATURES FOR OBSTRUCTIVE SLEEP APNEA

ASSISTANCE TO FIREFIGHTERS GRANT

DOMESTIC WATER GRANTS - REGULAR

DEVELOPMENT OF AN ACCESSIBLE, HIGH-PRECISION HISTOLOGY PROCUREMENT SYSTEM

ASSISTANCE TO FIREFIGHTERS GRANTS

ASSISTANCE TO FIREFIGHTERS GRANTS

SEC. 9007 REAP-ENERGY EFFICIENCY IMPROVEMENTS GRANTS (MAN)

HONEA PATH TOWN RECOVERY ACT JAG PROJECT

ASSISTANCE TO FIREFIGHTERS GRANTS

PURPOSE: TO SUPPORT THE FINAL DEVELOPMENT AND PRESENTATION OF A NEW DANCE WORK BY CHOREOGRAPHER HELEN SIMONEAU IN COLLABORATION WITH COMPOSER AND MULTI-INSTRUMENTALIST ANGÉLICA NEGRÓN.

TO SUPPORT SALARIES AND ARTIST FEES FOR THE CREATION AND PRESENTATION OF DELICATE POWER BY CHOREOGRAPHER HELEN SIMONEAU.