University School

STRENGTHENING THE GOVERNMENT OF UGANDA'S CAPACITY FOR REGIONALLY CENTERED AND DISTRICT IMPLEMENTED HIV AND TB PROGRAMMING THROUGH HIS, CBS, M&E AND QI SUPPORT

HEALTH CENTER CLUSTER

HIGHER EDUCATION SOLUTIONS NETWORK COOPERATIVE AGREEMENT

MONITORING AND EVALUATION TECHNICAL SUPPORT (METS) TO STRENGTHEN MONITORING AND EVALUATION, DISEASE SURVEILLANCE AND THE CAPABILITIES OF DISTRICT HEALTH TEAMS IN THE REPUBLIC OF UGANDA UNDER

DEVELOPING NATIONAL CAPACITY FOR THE MANAGEMENT OF HIV/AIDS PROG & SUPPORT FOR TH

STRENGTHENING CIVIL SOCIETY ORGANIZATIONS'CAPACITY AND COORDINATION FOR ACCELERATED HIV EPIDEMIC CONTROL IN UGANDA THROUGH SUPPORTING IMPLEMENTATION OF COMPREHENSIVE HIV/AIDS PREVENTION AND TREATMENT

HEALTH CENTER CLUSTER

MONITORING AND EVALUATION TECHNICAL SUPPORT (METS) TO STRENGTHEN MONITORING AND EVALUATION, DISEASE SURVEILLANCE AND THE CAPABILITIES OF DISTRICT HEA

THE SOMATOTROPIC AXIS AND HEALTH AGING: A SEARCH FOR MECHANISMS

STRENGTHEN CAPACITY OF UGANDA MINISTRY OF HEALTH AND SUB - NATIONAL ENTITIES TO EXECUTE ESSENTIAL PUBLIC HEALTH FUNCTIONS THROUGH SUPPORTING PUBLIC HEALTH WORKFORCE DEVELOPMENT AND INSTITUTIONAL...

STRENGTHEN UGANDA MINISTRY OF HEALTH CAPACITY TO EXECUTE ITS ESSENTIAL PUBLIC HEALTH FUNCTIONS THROUGH PROVISION OF TECHNICAL ASSISTANCE, PUBLIC HEALTH WORKFORCE DEVELOPMENT AND INSTITUTIONAL

AMERICAN RESCUE PLAN ACT FUNDING FOR HEALTH CENTERS

CODING IN AUDITORY NEURONS: EFFECTS OF AMINO ACIDS

CELLULAR SENESCENCE, INFLAMMATION AND NEUROTRANSMISSION IN ALZHEIMER'S DISEASE

INTERACTION OF CALORIC RESTRICTION WITH LONGEVITY GENES

GLUTAMATE NEUROTRANSMISSION IN ALZHEIMER'S DISEASE PROGRESSION

OPTIMIZING D-METHIONINE (D-MET) PRE-LOADING AND RESCUE DOSING THROUGH FUNCTIONAL AND BIOMARKER MEASURES

ENDOGENOUS MODULATION OF COCHLEAR INJURY

RURAL COMMUNITIES OPIOID RESPONSE PROGRAM - MEDICATION ASSISTED TREATMENT ACCESS - PROJECT TITLE: SOUTHERN ILLINOIS UNIVERSITY (SIU) COMMUNITY HEALTH PROGRAM MEDICATION ASSISTED TREATMENT (MAT) EXPANSION PROJECT REQUESTED AWARD AMOUNT: $2,669,913 APPLICANT ORGANIZATION NAME: BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY FACILITY TYPE: PUBLIC UNIVERSITY AND FEDERALLY QUALIFIED HEALTH CENTER ADDRESS: 520 N 4TH STREET, SPRINGFIELD IL 62702-5238 WEBSITE: HTTPS://WWW.SIUMED.EDU/CENTERS-FAMILY-MEDICINE PROJECT DIRECTOR AND TITLE: CAMILLE DUNKLEY, MD, ASSISTANT PROFESSOR OF FAMILY AND COMMUNITY MEDICINE, DIRECTOR OF MEDICATION ASSISTED RECOVERY PROJECT DIRECTOR CONTACT: PHONE: 217-757-8137 FAX: 217-545-5806 EMAIL: CDUNKLEY46@SIUMED.EDU LEARNED OF FUNDING OPPORTUNITY: HRSA NEWS RELEASE & GRANTS.GOV BRIEF DESCRIPTION OF TARGET SERVICE AREA: TWO HRSA-DESIGNATED RURAL COUNTIES (CHRISTIAN AND MORGAN) IN ILLINOIS. TARGET POPULATION: RESIDENTS OF CHRISTIAN COUNTY: 95% WHITE (NON-HISPANIC), 1.3% AFRICAN AMERICAN (NON-HISPANIC), 1.6% HISPANIC OR LATINO, 0.3% AS AMERICAN INDIAN/ALASKA NATIVE (NON-HISPANIC). RESIDENTS OF MORGAN COUNTY: 88% WHITE (NON-HISPANIC), 6.8% AFRICAN AMERICAN (NON-HISPANIC), 2.5% HISPANIC OR LATINO, 0.2% AS AMERICAN INDIAN/ALASKA NATIVE (NON-HISPANIC). THE PRIMARY AIM OF THIS PROJECT IS TO ESTABLISH TWO OUTPATIENT MEDICATION-ASSISTED TREATMENT (MAT) CLINICS IN TAYLORVILLE AND JACKSONVILLE, IL, WHICH ARE IN CHRISTIAN AND MORGAN COUNTY, RESPECTIVELY. THESE CLINICS WILL BE ESTABLISHED WITHIN THE EXISTING SIU CENTER FOR FAMILY MEDICINE PRIMARY CARE CLINICS. THEY WILL PROVIDE LEVEL 1 TREATMENT SERVICES AS DESIGNATED BY THE ILLINOIS SUBSTANCE USE PREVENTION AND RECOVERY (SUPR) LICENSE. THESE CLINICS WILL SERVE PATIENTS WITH OPIOID USE DISORDER, ALCOHOL USE DISORDER, AND CO-OCCURRING ADDICTION AND MENTAL HEALTH DISORDERS. THE MAT OPTIONS WILL INCLUDE SUBLINGUAL BUPRENORPHINE, BUPRENORPHINE EXTENDED-RELEASE INJECTABLE, AND NALTREXONE-EXTENDED RELEASE INJECTABLE. BEHAVIORAL SERVICES WILL BE INTEGRATED INTO THE C LINIC AND OFFERED ON-SITE. ADDITIONAL ADJUNCTIVE SERVICES WILL INCLUDE PEER SUPPORT, COMMUNITY HEALTH WORKERS, AND CASE MANAGEMENT.

ENHANCING PHYSICAL ACTIVITY AFTER BREAST CANCER DIAGNOSIS: RANDOMIZED TRIAL

ORAL EPIGALLOCATECHIN GALLATE (EGCG) FOR TREATMENT OF CISPLATIN OTOTOXICITY

BEHAVIORAL HEALTH WORKFORCE EDUCATION AND TRAINING PROGRAM

SANGAMON COUNTY ILLINOIS ASSISTED OUTPATIENT TREATMENT

FEATURES OF CHRONIC TINNITUS IN AN ANIMAL MODEL AS INDICATED BY MEMRI AND MRS

BEHAVIORAL HEALTH WORKFORCE EDUCATION AND TRAINING PROGRAM- AMERICAN RESCUE PLAN

MONITORING AND EVALUATION TECHNICAL SUPPORT (METS) TO STRENGTHEN MONITORING AND EVALUATION, DISEASE SURVEILLANCE AND THE CAPABILITIES OF DISTRICT HEA

MONITORING AND EVALUATION TECHNICAL SUPPORT (METS) TO STRENGTHEN MONITORING AND EVALUATION, DISEASE SURVEILLANCE AND THE CAPABILITIES OF DISTRICT HEA

AFFORDABLE CARE ACT: PRIMARY CARE RESIDENCY EXPANSION

CEREBELLAR GRANULE CELL DYSFUNCTION IN SHANK3 MUTANT MICE - PROJECT SUMMARY/ABSTRACT AUTISM SPECTRUM DISORDER (ASD) IS A COMPLEX NEUROLOGICAL DISORDER ASSOCIATED WITH A BROAD COLLECTION OF GENETIC MUTATIONS AND ENVIRONMENTAL FACTORS. WHILE IDENTIFYING THE NEURAL UNDERPINNINGS OF ASD HAS BEEN A MAJOR FOCUS IN THE FIELD OF GENETICS AND NEUROSCIENCE, IT IS NOT CLEAR WHICH BRAIN REGION (S) AND CELL TYPES MAY BE FUNCTIONING ABNORMALLY TO GIVE RISE TO ASD. THE CEREBELLUM, A BRAIN REGION TYPICALLY CONSIDERED TO BE INVOLVED IN MOTOR COORDINATION AND CONTROL, HAS RECEIVED CONSIDERABLE ATTENTION FOR ITS POTENTIAL ROLE IN ASD, WITH A GROWING BODY OF CLINICAL EVIDENCE CORRELATING ASD DIAGNOSES WITH ABNORMALITIES IN CEREBELLAR ANATOMY, FUNCTION, AND MOTOR OR VESTIBULAR BEHAVIORS/FUNCTIONS. IN PARALLEL, CEREBELLAR INVOLVEMENT IN CIRCUITS OUTSIDE OF THE MOTOR SYSTEM PROVIDES A SUBSTRATE FOR THE CEREBELLUM TO INFLUENCE NON-MOTOR BEHAVIORS AND PROCESSES, SETTING THE STAGE FOR THE IMPORTANCE OF APPROPRIATE CEREBELLAR FUNCTION IN A HOST OF NEURAL PROCESSES. WITHIN THE CEREBELLUM, THE INITIAL INTEGRATION OF ALL INCOMING SENSORIMOTOR INFORMATION ENTERING THE CEREBELLAR CORTEX IS CARRIED OUT BY THE MORPHOLOGICALLY SIMPLE AND EXTREMELY DENSE POPULATION OF GRANULE CELLS. THESE GRANULE CELLS ALSO EXPRESS MANY HIGH RISK ASD-LINKED GENES, ESPECIALLY THOSE INVOLVED IN SYNAPTIC TRANSMISSION AND DEVELOPMENT. HOWEVER, LITTLE IS KNOWN ABOUT THE ROLE AND IMPORTANCE OF MANY ASD-LINKED GENES IN THE CEREBELLUM, ESPECIALLY IN GRANULE CELLS. IT IS ALSO NOT CLEAR WHAT ASPECTS OF CEREBELLAR GRANULE CELL FUNCTION AND CONNECTIVITY MAY BE IMPORTANT FOR SHAPING CERTAIN NON-MOTOR (AND MOTOR) BEHAVIORS. TO ADDRESS THIS KNOWLEDGE GAP, IN AIMS 1 AND 2 WE PROPOSE TO IDENTIFY THE DEGREE TO WHICH AN ASD-LINKED GENE DETERMINES PROPERTIES OF CEREBELLAR GRANULE CELL SYNAPTIC INTERACTIONS AND CORTICAL CIRCUITRY DYNAMICS OVER TIME. IN AIM 3, WE WILL IDENTIFY HOW A PARTICULAR ASD-LINKED GENE IN CEREBELLAR GRANULE CELLS INFLUENCE BEHAVIORAL PHENOTYPE ACROSS MOTOR AND NON-MOTOR DOMAINS. RESULTS FROM THE PROPOSED WORK WILL BE KEY IN IDENTIFYING A MECHANISTIC LINK BETWEEN A GENE/PROTEIN LINKED TO ASD AND SPECIFIC SYNAPTIC ABNORMALITIES IN THE CEREBELLUM.

MECHANISMS OF FATIGUE IN A CHRONIC VIRAL DISEASE

DEVELOPING D-METHIONINE AS AN AMINOGLYCOSIDE OTOPROTECTANT

NICOTINIC RECEPTOR PATHOLOGY IN TINNITUS: AUDITORY CORTEX AND SELECTIVE DESENSITIZING NICOTINIC AGENTS

NOVEL ROLE OF MYELOID-DERIVED LYMPHATIC PROGENITORS IN INDUCTION OF BREAST CANCER LYMPHATICS

MECHANISMS THAT REGULATE HAIR CELL SURVIVAL

TRANSPLATIN: A NOVEL AGENT TO MITIGATE CISPLATIN TOXICITY

INVESTIGATION OF NOTCH SIGNALING DURING SPONTANEOUS REGENERATION OF COCHLEAR HAIR CELLS

DEVELOPMENT OF NEW THERAPIES THAT STIMULATE HAIR CELL REGENERATION

NF-KB MEDIATED INDUCTION OF VEGFR-3 AND NEW LYMPHATIC VESSELS IN BREAST CANCER

PRIMARY CARE TRAINING AND ENHANCEMENT

A NOVEL APPROACH FOR CHRONIC PAIN TREATMENT USING RESINIFERATOXIN

CIRCADIAN CLOCK DISRUPTION: A MECHANISM FOR DIOXIN-INDUCED METABOLIC SYNDROME

THE GLYCINE RECEPTOR IN A RAT TINNITUS MODEL: A POSSIBLE THERAPEUTIC TARGET

RESEARCH IN PERVENTION AND TREATMENT OF NOISE-INDUCED HEARING LOSS (NHL)

MONITORING AND EVALUATION TECHNICAL SUPPORT (METS) TO STRENGTHEN MONITORING AND EVALUATION, DISEASE SURVEILLANCE AND THE CAPABILITIES OF DISTRICT HEA

BEHAVIORAL HEALTH WORKFORCE EDUCATION AND TRAINING PROGRAM - TRAUMA-BASED BEHAVIORAL HEALTH FELLOWSHIP: HEALING-CENTERED INTEGRATED AND INTERDISCIPLINARY CARE TRAINING PROJECT AIMS TO EXPAND AND SUSTAIN THE TRAUMA-INFORMED BEHAVIORAL HEALTH WORKFORCE IN SOUTHERN ILLINOIS, A REGION CHARACTERIZED BY RURAL, MEDICALLY UNDERSERVED COMMUNITIES (MUCS), AND DESIGNATED BY HRSA AS A HEALTHCARE WORKFORCE SHORTAGE AREA. THIS COLLABORATIVE INITIATIVE SEEKS TO ADDRESS HEALTH DISPARITIES BY ENHANCING THE PROVISION OF TRAUMA-INFORMED, BILINGUAL MENTAL HEALTH SERVICES TO CHILDREN, ADOLESCENTS, AND TRANSITIONAL-AGED YOUTH IN BEHAVIORAL HEALTH (BH) AND INTEGRATED CARE (IC) SETTINGS. AT THE HEART OF THIS PROJECT IS THE WIDELY RECOGNIZED TRAUMA-BASED BEHAVIORAL HEALTH FELLOWSHIP (TBBHF) AT SOUTHERN ILLINOIS UNIVERSITY (SIU) SCHOOL OF MEDICINE (SOM). AN INTEGRATED/INTERPROFESSIONAL TRAINING PROGRAM THAT EQUIPS GRADUATE STUDENTS FOR CAREERS IN BH. THE PROGRAM FOCUSES ON TRAUMA-INFORMED SYSTEMS OF CARE, INTEGRATED HEALTH SYSTEMS, AND PREPARING STUDENTS TO WORK EFFECTIVELY IN INTERDISCIPLINARY TEAMS WITH VULNERABLE POPULATIONS, PARTICULARLY IN RURAL AND UNDERSERVED COMMUNITIES. THIS PROJECT IS FOCUSED ON CHILDREN, ADOLESCENTS AND YOUNG ADULTS. BUILDING ON THE PROGRAM'S 11 YEARS OF SUCCESS, THE CONTINUED FUNDING WILL STRENGTHEN THE HYBRID, INTERDISCIPLINARY DIDACTIC TRAINING CURRICULUM WITH A FOCUS ON HEALING-CENTERED INTEGRATED TRAUMA-INFORMED CARE, EVIDENCE-BASED TRAUMA INTERVENTIONS, TELEHEALTH, AND ENHANCED CLINICAL OFFERINGS FOR STUDENTS, FACULTY, AND FIELD SITE SUPERVISORS. KEY COMPONENTS OF THE CONTINUATION PROJECT INCLUDE: ENHANCED SUPERVISION FRAMEWORK: DEVELOPMENT OF A ROBUST SUPERVISION CURRICULUM FOR BOTH MSW STUDENTS AND CLINICAL SUPERVISORS; EDUCATIONAL SESSIONS FOR CLINICAL SUPERVISORS IN THE REGION TO ENSURE QUALITY PRACTICE IN COMMUNITY MENTAL HEALTH ORGANIZATIONS; POST-GRADUATION OPPORTUNITIES FOR CLINICAL SUPERVISION TO SUPPORT LICENSURE ATTAINMENT. PROFESSIONAL DEVELOPMENT: A PREPARATORY COURSE FOR STUDENTS TO OBTAIN LICENSURE; GUIDED INSTRUCTION FOR OBTAINING AN NPI NUMBER, A PROGRAM REQUIREMENT; CONTINUING EDUCATION IN INTERDISCIPLINARY AND IC TEAMS FOR FIELD SITE SUPERVISORS TO ENHANCE INTEGRATED SERVICE DELIVERY AND STREAMLINE PATIENT CARE. DIVERSE CLINICAL CASELOADS: USING VIRTUAL TRAINING TO EXPOSE STUDENTS TO DIVERSE CLIENTS, DIAGNOSES, CULTURAL BACKGROUNDS, AND COMPLEX, MULTIFACETED CASES; OPPORTUNITIES FOR STUDENTS TO DEVELOP CRITICAL THINKING AND DECISION-MAKING SKILLS THROUGH SIMULATED AND REAL-WORLD SCENARIOS. ENHANCED SUPPORT FOR EXPERIENTIAL SITES: TARGETED TRAINING AND RESOURCES TO ASSIST EXPERIENTIAL SITES IN ADOPTING IC SYSTEMS AND PROVIDING STREAMLINED, PATIENT-CENTERED SERVICES. THIS PROJECT WILL RECRUIT A DIVERSE GROUP OF 48 STUDENTS OVER THE 4-YEAR GRANT PERIOD, FROM THE MSW PROGRAM AT SOUTHERN ILLINOIS UNIVERSITY CARBONDALE. EACH STUDENT WILL BE ASSIGNED A MENTOR/SITE SUPERVISOR AT ONE OF THE 7 INTEGRATED/INTERDISCIPLINARY SITES. ONCE ACCEPTED, THE MSW FELLOWS WILL ATTEND A DIDACTIC TRAINING EVERY FRIDAY FOR 4 HOURS OVER TWO SEMESTERS. THE HEALING-CENTERED INTEGRATED INTERDISCIPLINARY CURRICULUM IS BUILT ORGANICALLY WITH THE LATEST RESEARCH IN TRAUMA INFORMED EVIDENCE BASED CLINICAL PRACTICES. TO FORTIFY THE MSW TFS PROFESSIONAL GROWTH AND CLINICAL SUCCESS, A HEALING-CENTERED INTEGRATED INTERDISCIPLINARY CLINICAL SUPERVISION TRAINING. WITH ADDITIONAL GROUP CONSULTATION. WILL BE A RESOURCE FOR THE SITE SUPERVISORS, WHO WILL MEET QUARTERLY FOR CONSULTATION. ADDITIONAL PROFESSIONAL DEVELOPMENT ENHANCEMENT FOR GRADUATING STUDENTS INCLUDE A LICENSING PREP COURSE AND CONNECTION TO EMPLOYMENT OPPORTUNITIES IN THE MEDICAL UNDERSERVED REGION OF SOUTHERN ILLINOIS. THIS WILL INCREASE THE SUPPLY OF A DIVERSE BH WORKFORCE WHO ARE TRAINED TO PROVIDE INTEGRATED CARE IN RURAL SOUTHERN ILLINOIS WHICH AIMS TO IMPROVE PATIENT CARE AND HEALTH EQUITY. THIS PROJECT MEETS THE QUALIFICATIONS FOR A FUNDING PRIORITY AND PREFERENCE. (ATTACHMENT 8)

15-LIPOXYGENASE-2 (ALOX15B) AS A TUMOR SUPPRESSOR

HEALTH CENTER CORONAVIRUS AID, RELIEF, AND ECONOMIC SECURITY (CARES) ACT FUNDING

CONGRESSIONALLY DIRECTED SPENDING FOR CONSTRUCTION PROJECTS

COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - NON-CONSTRUCTION

PRIMARY CARE TRAINING AND ENHANCEMENT -- RESIDENCY TRAINING IN STREET MEDICINE - THE PROPOSED SOUTHERN ILLINOIS UNIVERSITY (SIU) SCHOOL OF MEDICINE PROJECT IS ENTITLED PRISM – PREPARING RESIDENTS IN STREET MEDICINE – SEEING HOMELESS CARE THROUGH A NEW LENS IN CENTRAL AND SOUTHERN ILLINOIS. THE PURPOSE OF THIS PROJECT IS TO PREPARE SIU FAMILY MEDICINE RESIDENTS ACROSS THREE RESIDENCY SITES IN CENTRAL AND SOUTHERN ILLINOIS – ONE SUBURBAN AND TWO RURAL - TO DELIVER HIGH QUALITY, INNOVATIVE CARE TO INDIVIDUALS EXPERIENCING HOMELESSNESS IN THEIR COMMUNITIES AS WELL AS THE KNOWLEDGE, LEADERSHIP, AND INTER-PROFESSIONAL COLLABORATION SKILLS NEEDED TO ADAPT THIS CARE TO THEIR FUTURE PRACTICE COMMUNITIES. FAMILY MEDICINE RESIDENTS WILL GAIN EXPERTISE IN THE UNIQUE CHALLENGES OF CHRONIC DISEASE MANAGEMENT, SUBSTANCE USE DISORDER, AND MENTAL HEALTH THROUGH A ROBUST EXPANSION OF DIDACTICS AND COMMUNITY PARTNERSHIPS AS WELL AS DIRECT HANDS-ON EXPERIENTIAL LEARNING WITH SIU FACULTY USING STATE-OF-THE-ART SIMULATIONS AND CLINICAL ROTATIONS. FAMILY MEDICINE RESIDENTS WILL HAVE THE OPPORTUNITY TO BUILD ON THEIR SKILLS THROUGH DIRECT CARE OF INDIVIDUALS EXPERIENCING HOMELESSNESS AS A MEMBER OF THE SIU STREET MEDICINE TEAM. THIS INNOVATIVE TEAM WILL ALLOW RESIDENTS TO LEARN FIRSTHAND THE CHALLENGES OF CARE DELIVERY IN A NONTRADITIONAL MODEL THROUGH AD HOC STREET BASED CLINICAL CARE AS WELL AS THE IMPORTANCE OF INTER-PROFESSIONAL AND COMMUNITY COLLABORATION AS THEY PROVIDE DIRECT SERVICE TO THE NEARLY 800 INDIVIDUALS EXPERIENCING HOMELESSNESS ACROSS THREE RESIDENCY SITES IN A MIXTURE OF SUBURBAN AND RURAL CARE SETTINGS. THIS PROJECT REQUESTS CONSIDERATION FOR FUNDING PRIORITY BY TRAINING RESIDENTS IN RURAL AREAS AND ALSO FOR FUNDING PREFERENCE DUE TO PLACING 67% OF THE LAST 2 YEARS OF GRADUATES IN MEDICALLY UNDERSERVED COMMUNITIES.

CONGRESSIONALLY DIRECTED SPENDING FOR CONSTRUCTION PROJECTS

CELL-TYPES SPECIFIC NEUROADAPTATIONS IN THE NUCLEUS ACCUMBENS SHELL ASSOCIATED WITH INDIVIDUAL DIFFERENCES IN COCAINE-SEEKING - PROJECT SUMMARY/ABSTRACT ALTHOUGH COCAINE IS POWERFULLY REWARDING, NOT ALL PEOPLE WHO ARE EXPOSED TO THIS DRUG ARE EQUALLY PRONE TO ABUSING IT. THE REASONS FOR THESE DIFFERENCES REMAIN UNKNOWN BUT MAY INVOLVE PREDISPOSING FACTORS WHOSE ELUCIDATION COULD LEAD TO THERAPIES THAT, IN THE FUTURE, MAY PREVENT COCAINE ADDICTION. ONE SUCH PREDISPOSING FACTOR IS BEHAVIORAL SENSITIVITY TO THE AVERSIVE ATTRIBUTES OF COCAINE, WHICH OVERLAP WITH THE REWARDING EFFECTS TO PROTECT AGAINST COCAINE-SEEKING. PRELIMINARY DATA IN THIS PROPOSAL SUGGEST THAT THE AVERSIVE EFFECT OF COCAINE MAY BE MUCH STRONGER IN SOME INDIVIDUALS THAN OTHERS AND POTENTIALLY A DETERMINANT FOR COCAINE ADDICTION VULNERABILITY. THE UNDERLYING CELLULAR MECHANISM OF THIS VARIABILITY REMAINS UNKNOWN. HOWEVER, OUR PRELIMINARY DATA REVEALED THAT HIGHER RHOA ACTIVITY AND D2-MSN EXCITABILITY IN THE MNACSHELL CORRELATE WITH RATS DISPLAYING HIGHER AVERSIVE EFFECTS OF COCAINE (AND CONSEQUENTLY LOWER DRIVE TO SEEK COCAINE). NEVERTHELESS, IT IS UNKNOWN IF THESE CELLULAR AND MOLECULAR ADAPTATIONS IN THE MNACSHELL ARE INVOLVED IN THE AVERSIVE ATTRIBUTES OF COCAINE. ACCORDINGLY, TO ADDRESS THIS GAP IN KNOWLEDGE, I’M PROPOSING TWO AIMS. IN AIM 1, I WILL DETERMINE THE ROLES OF D2MSN ON COCAINE AVOIDANCE BEHAVIOR, AND FOR THIS, I WILL BE TRAINED IN FIBER PHOTOMETRIC AND OPTOGENETIC METHODS. I HYPOTHESIZE THAT D2- BUT NOT D1-MSNS ARE ACTIVATED DURING COCAINE’S AVERSIVE PHASE, AND THAT D2 ACTIVITY IN TURN DRIVES CONDITIONED NEGATIVE ATTRIBUTES OF COCAINE. IN AIM 2, I WILL EXAMINE THE ROLES OF RHOA AND RELATED GENES ON NEURAL EXCITABILITY AND COCAINE AVOIDANCE IN A CELL-SPECIFIC MANNER. FIRST, I WILL USE MRNA TRAP METHODS TO ANALYZE CELL-SPECIFIC GENE TRANSLATION ASSOCIATED WITH RHOA SIGNALING OR EXCITABILITY LINKED TO COCAINE AVOIDANCE PHENOTYPES. IN ADDITION, TO TEST THE CAUSAL ROLE OF RHOA IN EXCITABILITY AND COCAINE AVOIDANCE BEHAVIOR, I WILL DECREASE OR INCREASE RHOA ACTIVITY IN A CELL-SPECIFIC MANNER USING AN ADENO-ASSOCIATED GENE MANIPULATION STRATEGY. I HYPOTHESIZE THAT INCREASES IN RHOA ACTIVITY IN D2-MSN BUT NOT D1-MSN ENHANCES EXCITABILITY IN THE MNACSHELL CONFER PROTECTION AGAINST THE ACQUISITION OF COCAINE-SEEKING. AN INTENSE AND COMPREHENSIVE TRAINING, MENTORING, AND RESEARCH PLAN HAS BEEN DEVELOPED TO ACHIEVE THESE GOALS. THIS PLAN WILL BE GUIDED BY A POWERFUL TEAM OF MENTORS AND COLLABORATORS THAT WILL HELP BLEND MY CURRENT SKILL SET WITH NEW CONCEPTUAL AND TECHNICAL FRAMEWORKS AS I CONTINUE TO ESTABLISH MY OWN UNIQUE AND INNOVATIVE RESEARCH PROGRAM IN ADDICTION NEUROSCIENCE.

MECHANISM OF TUMOR METASTASES SUPPRESSION BY DRG1

A NOVEL GABAA RECEPTOR SUBTYPE IN AUDITORY THALAMUS: A POTENTIAL NEW TARGET FOR TINNITUS TREATMENT

HEALTH CENTER INFRASTRUCTURE SUPPORT

ARYL HYDROCARBON RECEPTOR REGULATION OF ENERGY METABOLISM

COMMUNICATION BETWEEN NEIGHBORING RYANODINE RECEPTOR CHANNELS IN SKELETAL MUSCLE

PRIMARY CARE TRAINING AND ENHANCEMENT

RURAL COMMUNITIES OPIOID RESPONSE-IMPLEMENTATION

INFLUENCE OF ENDOCRINE DISRUPTORS ON REPRODUCTIVE NEUROENDOCRINE FUNCTION

DEPRESSING NRIP1 REDUCES IGF1 SIGNALING IMPROVES METABOLISM AND EXTENDS LONGEVITY

EMSC TARGETED ISSUE GRANTS

TARGETING ATTENTIONAL MECHANISMS IN TINNITUS: CONTRIBUTION OF THE THALAMIC CHOLINERGIC SYSTEM

1/2 ADDRESSING RURAL CANCER HEALTH DISPARITIES: AN SCC-SIUSM PARTNERSHIP

FY 2020 EXPANDING CAPACITY FOR CORONAVIRUS TESTING (ECT)

ADDICTION MEDICINE FELLOWSHIP - ACCORDING TO THE NATIONAL INSTITUTE OF DRUG ABUSE (NIDA), 40 MILLION AMERICANS HAD A SUBSTANCE USE DISORDER (SUD) DIAGNOSIS IN 2020. HOWEVER, LESS THAN 7% OF THEM RECEIVED TREATMENT. ALTHOUGH, SEVERAL STRATEGIES HAVE BEEN DEVELOPED TO COMBAT THIS PUBLIC HEALTH CRISIS, THE ROLE HEALTHCARE PROVIDERS PLAY IS STILL CENTRAL. ADDICTION MEDICINE IS A MEDICAL SUBSPECIALTY THAT FOCUSES ON THE PREVENTION, EVALUATION, DIAGNOSIS, AND TREATMENT OF INDIVIDUALS WITH THE DISEASE OF ADDICTION. THE FIELD WAS OFFICIAL RECOGNIZED BY THE AMERICAN BOARD OF MEDICAL SPECIALTIES (ABMS) AS A SUBSPECIALTY IN 2016. CURRENTLY, THERE ARE 106 ACGME (ACCREDITATION COUNCIL FOR GRADUATE MEDICAL EDUCATION) ACCREDITED ADDICTION MEDICINE FELLOWSHIPS IN THE UNITED STATES. HOWEVER, THE MAJORITY ARE IN URBAN AREAS. THIS IS PARTICULARLY EVIDENT THROUGHOUT THE MIDWESTERN REGION AND CAN LIMIT ACCESS TO ADDICTION SERVICES FOR RURAL POPULATIONS. THEREFORE, THE PURPOSE OF THIS APPLICATION IS TO OBTAIN FUNDING TO SPONSOR TWO ADDICTION FELLOWSHIP POSITIONS IN SPRINGFIELD, ILLINOIS. SPRINGFIELD IS A CITY IN CENTRAL ILLINOIS SURROUNDED BY RURAL COMMUNITIES. THE PROGRAM CURRICULUM EMPHASIZES SKILLS AND KNOWLEDGE NECESSARY TO PRACTICE ADDICTION MEDICINE IN RURAL AND UNDERSERVED MEDICAL COMMUNITIES. WE ARE REQUESTING FUNDING PRIORITY (PRIORITY 3) AND FUNDING PREFERENCE (QUALIFICATION 3) IN THE SUBMISSION OF THE APPLICATION.

CODING IN AUDITORY NEURONS: EFFECTS OF AMINO ACIDS - PROJECT SUMMARY AGE-RELATED HEARING LOSS (ARHL) IS A COMPLEX DISORDER AFFECTING BETWEEN 50-70% OF THE UNITED STATES POPULATION AGED 65 OR OLDER. IN PUBLIC SETTINGS, SENIORS FREQUENTLY HAVE GREAT DIFFICULTY UNDERSTANDING SPEECH, WHICH CAN LEAD TO WITHDRAWAL FROM SOCIAL ACTIVITIES, DEPRESSION AND COGNITIVE DECLINE. ALL INDIVIDUALS AND ESPECIALLY THE ELDERLY CAN MAINTAIN SPEECH UNDERSTANDING IN DIFFICULT LISTENING CONDITIONS BY ENGAGING ATTENTIONAL, COGNITIVE AND MNEMONIC (TOP-DOWN) RESOURCES TO HELP DISAMBIGUATE SPEECH FROM A DEGRADED ASCENDING ACOUSTIC CODE. UNDERSTANDING THE IMPACT OF AGING ON CIRCUITS THAT MAINTAIN SPEECH UNDERSTANDING AND THE PHARMACOLOGY OF CHOLINERGIC ATTENTIONAL SYSTEMS IN THEIR MODULATION IS AT THE CORE OF THE PROPOSED STUDIES. STUDIES DURING THE PREVIOUS GRANT PERIOD IDENTIFIED DIFFERENTIAL AGE-RELATED CHANGES IN NICOTINIC CHOLINERGIC RECEPTOR (NACHR) SUBUNIT/SUBTYPES IN THE MEDIAL GENICULATE BODY (MGB) AND PRIMARY AUDITORY CORTEX (AI). IN VITRO AGING STUDIES DETAILED THE PRE- AND POSTSYNAPTIC FUNCTION OF NACHRS IN THALAMIC CIRCUITS LIKELY TO UNDERPIN ATTENTIONAL MODULATION OF ACOUSTIC INFORMATION. UNIT RECORDINGS FROM AWAKE RAT AUDITORY THALAMUS MGB ALSO SHOWED AGE-RELATED REPETITION-ENHANCEMENT, AS OPPOSED TO SENSORY ADAPTATION, IN RESPONSE TO REPEATING/PREDICTABLE TEMPORALLY RICH STIMULI. THIS WAS POSITED TO REFLECT INCREASED USE OF CORTICOFUGAL/HIGHER- ORDER RESOURCES. AGE-RELATED ENHANCED CODING OF REPEATING MODULATED STIMULI WAS REPRODUCED IN YOUNG ANIMALS BY SIMPLY DEGRADING THE TEMPORAL CLARITY OF THE SINUSOIDAL AMPLITUDE MODULATED (SAM) STIMULI. CORTICOTHALAMIC BLOCKADE OF PROJECTIONS TO MGB REVERSED PREDICTIVE REPETITION-ENHANCEMENT TO A DEGREE, BUT NOT COMPLETELY. THE PROPOSED SPECIFIC AIMS WILL ADDRESS QUESTIONS RAISED BY THESE PRIOR STUDIES AND SUPPORTED BY PRELIMINARY DATA. IN VITRO AND IN VIVO APPROACHES IN RATS WILL: SA1: CHARACTERIZE THE FUNCTIONAL PHARMACOLOGY AND THE IMPACT OF AGING ON NACHR PHARMACOLOGY IN THE CENTRAL AND DORSAL NUCLEI OF THE INFERIOR COLLICULUS (CNIC, ENIC AND DNIC). SA2A: DETERMINE SINGLE UNIT RESPONSE PROPERTIES OF CNIC AND DNIC UNITS TO TEMPORALLY DISTINCT AND LESS TEMPORALLY DISTINCT SAM STIMULI PRESENTED IN REPEATING/PREDICTABLE OR RANDOM SEQUENCES. SA2B: DETERMINE THE IMPACT OF AGING ON THE RESPONSE PROPERTIES OF CNIC AND DNIC UNITS TO REPEATING VS. RANDOMLY PRESENTED SAM STIMULI. SA3. DETERMINE THE IMPACT OF PONTINE MESENCEPHALIC TEGMENTUM (PMT) RELEASE OF ACETYLCHOLINE ON THE RESPONSE PROPERTIES OF IC UNITS TO TEMPORALLY DISTINCT AND TEMPORALLY LESS DISTINCT SAM STIMULI PRESENTED IN A REPEATING OR RANDOM SEQUENCES. UNDERSTANDING THE MECHANISMS INVOLVED IN REPETITION ENHANCEMENT/PREDICTIVE CODING AND IDENTIFICATION OF NOVEL NACHR SUBTYPES POTENTIALLY RESISTANT TO AGING WILL INFORM FUTURE BEHAVIORAL AND PHARMACOTHERAPEUTIC APPROACHES TO IMPROVE SPEECH UNDERSTANDING IN THE ELDERLY.

TARGETING TUMOR OCT4 TO DEPLETE PROSTATE TUMOR- AND METASTASIS-INITIATING CELLS

RESIDENCY TRAINING IN PRIMARY CARE

DEVELOPMENT OF AN EFFECTIVE GENITAL HERPES VACCINE

THE SURVIVOR RECOVERY CENTER AT THE SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE WILL IMPLEMENT THE TRAUMA RECOVERY CENTER EXPANSION PROJECT TO INCREASE THE AVAILABILITY OF TRAUMA-FOCUSED, EVIDENCE-BASED BEHAVIORAL HEALTH SERVICES FOR CRIME VICTIMS AGED 18-54 IN SANGAMON COUNTY, ILLINOIS. DIRECT SERVICES WILL INCLUDE INDIVIDUAL AND GROUP THERAPY, CASE MANAGEMENT, AND REFERRAL PATHWAYS FOR PSYCHIATRIC SERVICES.

LEICA TCS SP5 SPECTRAL LSCM FOR THE RESEARCH IMAGING FACILITY

AGING AT THERMONEUTRAL TEMPERATURE

NEUROPROTECTION IN PARKINSON DISEASE: CLINICAL CENTER

TESTING DEVELOPING THE NEXT GENERATION TENT TO SUPPORT EBOLA TREATMENT UNITS AND HUMANITARIAN SERVICE DELIVERY IN HOT CLIMATIC CONDITIONS

FACS ARIA II FOR FLOW CYTOMETRY CORE FACILITY

DEFINITION OF STRUCTURAL ORGANIZATION AND ENZYMOLOGY OF THE EBV PROTEIN KINASE.

ROLE OF TH2 CYTOKINES IN PROGENITOR-MEDIATED FORMATION OF TUMOR LYMPHATICS - PROJECT SUMMARY/ABSTRACT ROLE OF TH2 CYTOKINES IN PROGENITOR-MEDIATED FORMATION OF TUMOR LYMPHATICS LYMPH NODE METASTASIS, A COMMON EVENT IN BREAST CANCER, IS A STRONG INDICATOR OF POOR OUTCOME DUE TO SPREAD OF NODAL METASTATIC CELLS TO DISTANT ORGANS WHICH LEADS TO MORTALITY OF PATIENTS. METASTATIC BURDEN IN LYMPH NODES DIRECTLY CORRELATES WITH THE DENSITY OF TUMOR LYMPHATIC VESSELS. OUTGROWTH OF THESE VESSELS IS PROMOTED BY BONE MARROW (BM) DERIVED PROGENITORS THAT CO-EXPRESS SPECIFIC MARKERS OF LYMPHATIC ENDOTHELIAL CELLS AND M2- TYPE MACROPHAGES. THIS SUBSET DUBBED MYELOID-DERIVED LYMPHATIC ENDOTHELIAL CELLS PROGENITORS (M-LECP) IS PRESENT IN MICE AND PATIENTS WITH METASTATIC BREAST TUMORS BUT NOT IN CANCER-FREE INDIVIDUALS. WE PREVIOUSLY SHOWED IN CLINICAL BREAST CANCERS THAT DENSITY OF LYMPHATIC PROGENITORS SIGNIFICANTLY CORRELATES WITH TUMOR LYMPHATIC FORMATION AND METASTASES IN LYMPH NODES. THESE DATA UNDERSCORE THE CLINICAL SIGNIFICANCE OF M-LECP AND THE NEED TO DEFINE THEIR PROPERTIES AND THE MECHANISMS THAT INDUCE TUMOR LYMPHATICS FORMATION. WE PREVIOUSLY SHOWED THAT M-LECP ARE M2-MYELOID CELLS WITH LYMPHATIC-SPECIFIC MARKERS WHEREAS NEWLY FORMED LYMPHATIC VESSELS EXPRESS MACROPHAGE-SPECIFIC MARKERS. THIS MISALIGNMENT BETWEEN THE MARKERS AND THEIR RESPECTIVE LYMPHATIC/MYELOID LINEAGES IS WELL-DOCUMENTED BUT UNEXPLAINED. HOWEVER, IT CAN BE EXPLAINED CONSIDERING THE TRAITS OF OTHER BM PROGENITORS KNOWN TO ADOPT THE PHENOTYPE OF LINEAGES TARGETED FOR REPAIR, AND TO EMPLOY FUSION AS THE MEANS TO INITIATE THE REPAIR BY INSERTING A TRIGGER FOR CELL PROLIFERATION. FUSION OF BM PROGENITORS WITH TARGETED CELLS RESULTS IN TRANSFER OF GENOMIC MATERIAL ENCODING FOR M2 MYELOID MARKERS WHICH EXPLAINS THEIR APPEARANCE IN NEW STRUCTURES. WE REASONED THAT M-LECP, MYELOID PROGENITORS WITH PARTIAL LYMPHATIC IDENTITY, MIGHT SIMILARLY USE BM-ENABLED FUSOGENIC PROPERTIES TO EXPAND LYMPHATIC VESSELS. OUR PRELIMINARY DATA SHOW THAT MYELOID PRECURSORS TREATED WITH TH2 CYTOKINES IL-4, IL-13 AND IL-10 IN VITRO DIFFERENTIATE INTO CELLS WITH COMBINED M2-MYELOID, LYMPHATIC ENDOTHELIAL, AND FUSOGENIC PHENOTYPES. THIS LED TO THE HYPOTHESIS THAT ACTIVATION OF TH2 PATHWAYS IN M2-BIASED MYELOID PRECURSORS CO-REGULATES LYMPHATIC LINEAGE-SPECIFIC AND FUSOGENIC PROPERTIES THAT COLLECTIVELY PROMOTE THE ABILITY OF MATURE PROGENITORS TO INDUCE NEW LYMPHATIC VESSELS. THIS HYPOTHESIS IS SUPPORTED BY OUR DATA THAT DEMONSTRATE CO-DEVELOPMENT OF M2, LYMPHATIC, AND FUSOGENIC PROPERTIES IN DIFFERENTIATED M-LECP AS WELL AS MULTIPLE EVIDENCE FOR FUSION OF THESE PROGENITORS WITH LYMPHATIC ENDOTHELIAL CELLS IN VIVO AND IN VITRO. WE WILL TEST THIS HYPOTHESIS THROUGH THE FOLLOWING SPECIFIC AIMS: (1) DETERMINE IN VIVO THE SIGNIFICANCE OF TH2 PATHWAYS IN M-LECP DRIVEN TUMOR LYMPHANGIOGENESIS; AND (2) DETERMINE WHETHER FUSOGENIC PROPERTIES INDUCED BY TH2 FACTORS AND ITS REGULATOR TLR4 ENABLE M-LECP TO TRIGGER TUMOR LYMPHATIC FORMATION. SIGNIFICANCE: TH2 FACTORS COULD PLAY A PARAMOUNT ROLE IN ENABLING THE LYMPHANGIOGENIC FUNCTION OF M-LECP THROUGH FUSION, A CONCEPT THAT PROVIDES A NOVEL FRAMEWORK FOR DELINEATING GENERATION OF TUMOR LYMPHATIC VESSELS. EXPLORATION OF THIS CONCEPT CAN LEAD TO NEW THERAPEUTIC TARGETS PAVING THE WAY FOR SUPPRESSION OF TUMOR LYMPHATICS AND INHIBITION OF LYMPH NODE METASTASIS.

NETWORK MODULATORS OF AUDITORY THALAMOCORTICAL FEEDBACK INHIBITION

PRO-INFLAMMATORY REGULATION OF ANGIOGENIC GENE EXPRESSION IN HUMAN TROPHOBLAST

TARGETING INFLAMMATION FOR THE AMELIORATION OF CISPLATIN-HEARING LOSS

A NOVEL BIOTHERAPEUTIC FOR TRIPLE-NEGATIVE BREAST CANCER.

TAU-BINDING B CELLS IN ALZHEIMER'S DISEASE

NOVEL APPROACHES FOR PREVENTION AND TREATMENT OF NOISE INDUCED HEARING LOSS

HIGHER EDUCATION EMERGENCY RELIEF FUND - FIPSE

DEVELOPMENTAL PROGRAMMING OF MAMMALIAN AGING

IGM VS IGG NATURAL ANTIBODIES THAT BIND PATHOGENIC APOLIPOPROTEIN B100

CUX1 AND CELL CYCLE REGULATION IN KIDNEY DEVELOPMENT AND DISEASE

PREVENTION OF SEIZURE-INDUCED SUDDEN DEATH BY PERIAQUEDUCTAL GRAY STIMULATION - PROJECT ABSTRACT EPILEPSY IS A COMMON AND SERIOUS BRAIN DISORDER THAT CAN BE FATAL. THE RISK OF SUDDEN DEATH IS 24 TIMES GREATER IN EPILEPSY PATIENTS THAN THE GENERAL POPULATION, AND SUDDEN UNEXPLAINED DEATH IN EPILEPSY (SUDEP) RANKS 2ND HIGHEST AMONG NEUROLOGIC DISEASES IN POTENTIAL YEARS OF LIFE LOST. THERE ARE CURRENTLY NO PREVENTATIVE TREATMENTS FOR THIS DEVASTATING EPILEPSY SEQUELAE. THEREFORE, RESEARCH INTO MECHANISMS FOR PREVENTION OF SUDEP IS CRITICALLY IMPORTANT, AS INDICATED IN THE NINDS BENCHMARKS. DEATH IN MOST WITNESSED SUDEP CASES RESULTS FROM GENERALIZED TONIC-CLONIC SEIZURES (GTCS) LEADING TO TERMINAL APNEA. WE HAVE DEVELOPED THE DBA/1 MOUSE MODEL OF SUDEP, WHICH MIMICS HUMAN SUDEP IN THAT IT EXHIBITS GTCS AND SEIZURE-INDUCED RESPIRATORY ARREST (S-IRA) THAT LEADS DIRECTLY TO DEATH. SEVERAL OTHER LABS HAVE RECENTLY UTILIZED THIS MODEL. RESEARCH IN DBA/1 MICE LED TO THE DEVELOPMENT OF THE SEROTONIN THEORY OF SUDEP, WHICH HAS RECEIVED POSITIVE SUPPORT IN RECENT STUDIES IN EPILEPSY PATIENTS. THIS HYPOTHESIS, FIRST PROPOSED BY OUR LAB IS BASED, IN PART, ON THE FINDINGS THAT TREATMENTS WHICH ENHANCE THE ACTION OF SEROTONIN BLOCK SEIZURE-INDUCED DEATH. THE SUDEP MODELS IN WHICH THE HYPOTHESIS HAS BEEN TESTED INCLUDE THE DRAVET MICE, WHICH MODEL DRAVET SYNDROME, AN INTRACTABLE FORM OF HUMAN EPILEPSY THAT HAS A HIGH RISK FOR SUDEP. DRAVET MICE ARE GENETICALLY MODIFIED TO MIMIC HUMAN DRAVET SYNDROME AND ALSO SHOW SUDDEN DEATH DUE TO S- IRA. DRAVET MICE EXHIBIT HEAT-INDUCED SEIZURES, AND DEATH CAN BE PREVENTED BY TIMELY RESUSCITATION SIMILAR TO DBA/1 MICE. IMPORTANTLY, IN EPILEPSY PATIENTS NON-FATAL BUT SIGNIFICANT RESPIRATORY DEFICITS FREQUENTLY OCCUR AFTER GTCS, AND POSTICTAL APNEA IS THE MOST COMMON CAUSE OF HUMAN SUDEP. THIS PROPOSAL WILL UTILIZE DBA/1 AND DRAVET MICE TO TEST PREVENTATIVE MEASURES FOR SUDEP. OUR RECENT NEUROIMAGING STUDIES IN DBA/1 MICE HAVE PROVIDED SUGGESTIVE EVIDENCE THAT A SPECIFIC BRAINSTEM SITE- THE PERIAQUEDUCTAL GRAY (PAG)-MAY BE CRITICAL IN PREVENTING SEIZURE-INDUCED DEATH. THE PAG IS KNOWN TO PLAY A CRITICAL ROLE TO COMPENSATE FOR MANY TYPES OF NON-EPILEPSY-RELATED RESPIRATORY DEFICITS. PAG STIMULATION IS CURRENTLY USED IN PATIENTS TO TREAT CHRONIC PAIN AND WILL ENHANCE RESPIRATION. WE HAVE PRELIMINARILY EVALUATED THE EFFECTS OF PAG STIMULATION AND FOUND THAT IT ENHANCES RESPIRATION IN ANESTHETIZED DBA/1 MICE. THEREFORE, WE WILL EXPLORE IF PAG ELECTRICAL STIMULATION WILL ENHANCE RESPIRATION AND REVERSE S-IRA FOLLOWING SEIZURES INDUCED IN BEHAVING DBA/1 AND DRAVET MICE. AIM 1: TO EXPLORE IF TIMELY ELECTRICAL STIMULATION OF THE PAG CAN PREVENT AUDIOGENIC SEIZURE-INDUCED RESPIRATORY ARREST (S-IRA) AND DEATH IN THE DBA/1 MOUSE MODEL OF SUDEP. AIM 2: TO EXAMINE IF TIMELY PAG ELECTRICAL STIMULATION CAN PREVENT SEIZURE-INDUCED SUDDEN DEATH IN THE DRAVET MOUSE MODEL OF SUDEP INDUCED BY ELEVATED TEMPERATURE.

CELL SOURCE AND MECHANISM OF HAIR CELL REGENERATION IN THE NEONATAL MOUSE COCHLEA

RENAL CELL TUMOR-MEDIATED TRANS-DIFFERENTIATION OF NATURAL KILLER CELLS

ROLE OF ALDOSE REDUCTASE-LIKE-1 IN COLON TUMORIGENESIS

AGE-RELATED RESPONSE OF HIPPOCAMPAL NEURONS TO STRESS

FY 2023 EXPANDING COVID-19 VACCINATION

PHYSICAL ACTIVITY BENEFITS AFTER BREAST CANCER: EXPLORING CYTOKINE MECHANISMS

DEVELOPMENTAL ORIGINS OF PHENOTYPIC CHARACTERISTICS THAT PREDICT LONGEVITY

THE ROLE OF AFRICAN GREEN MONKEYS IN THE EPIDEMIOLOGY OF DENGUE AND CHIKUNGUNYA ON ST KITTS, WEST INDIES

SEX-DIFFERENTIAL EFFECTS OF ADJUVANTED AND NON-ADJUVANTED RABIES VACCINES ON ALL-CAUSE MORTALITY IN A NOVEL ANIMAL MODEL: UNDERSTANDING NON-SPECIFIC EFFECTS OF VACCINES IN HIGH-MORTALITY POPULATIONS

CONFOCAL MICROSCOPE FOR THE INVESTIGATION OF HEARING LOSS, OTOPROTECTION, AND TINNITUS

CHARACTERIZATION OF A NOVEL QUORUM QUENCHING PROTEIN PRODUCED BY S AUREUS

HIGHER EDUCATION EMERGENCY RELIEF FUND - INSTITUTIONAL PORTION

A MEMORY CD4 T-CELL BIOMARKER PREDICTS T1D PROGRESSION AND TREATMENT RESPONSE

TO IMPLEMENT A RESEARCH AND INNOVATION CAPACITY BUILDING PROJECT IN PARTNERSHIP WITH MICHIGAN STATE UNIVERSITY TO STRENGTHEN MAKERERE UNIVERSITY'S RESEARCH, GRANT WRITING AND PUBLICATION CAPACITY.

RURAL COMMUNITIES OPIOID RESPONSE (PLANNING)

MICROBRIGHTFIELD BIOSCIENCE IMAGING SYSTEM

EMERGENCY FINANCIAL AID GRANTS TO STUDENTS UNDER THE CORONAVIRUS AID, RELIEF, AND ECONOMICSECURITY (CARES)ACT.

DISTANCE LEARNING GRANT

ARRA - EQUIPMENT TO ENHANCE TRAINING FOR HEALTH PROFESSIONALS

B1A CELL FUNCTION IN SICKLE CELL DISEASE

TARGETING QUIESCENT CANCER CELLS TO ELIMINATE TUMOR RECURRENCE AFTER THERAPY

DIAGNOSTIC UTILITY OF CULDOCENTESIS IN PATIENTS WITH A SUSPICIOUS ADNEXAL MASS

SHIFT WORK AND LONGEVITY IN DISEASE-PRONE INBRED MICE

IDENTIFY GENETIC MECHANISMS THAT REGULATE FEMALE SEXUAL MATURATION

CODING IN AUDITORY NEURONS: EFFECTS OF AMINO ACIDS

STRENGTHENING THE MEDICAL EXAMINER - CORONER SYSTEM FELLOWSHIP PROGRAM IN THE MIDWEST

AMELIORATION OF CISPLATIN OTOTOXICITY BY TRANSPLATIN

IDENTIFICATION AND RECONSTRUCTION OF PROSTATE TUMOR-SUPPRESSING EXOSOMES FOR THERAPEUTIC APPLICATIONS

ADENOSINE A3 RECEPTOR SUPPRESSES PROSTATE CANCER METASTASIS BY INHIBITING

THE ROLE OF MICRORNA EDITING IN BREAST CANCER

A NOVEL THERAPY FOR METASTATIC MELANOMA

PROSPECTING THE VENOM OF A TROPICAL PREDATORY ANT FOR ANTICANCER DRUG

A NOVEL BIOTHERAPEUTIC FOR TRIPLE-NEGATIVE BREAST CANCER

SUSCEPTIBILITY OF AFRICAN GREEN MONKEYS (CHLOROCEBUS AETHIOPS SABAEUS) TO RICKETTSIA FELIS, THE AGENT OF FLEA-BORNE SPOTTED FEVER - FLEA-BORNE SPOTTED FEVER (FBSF) CAUSED BY RICKETTSIA FELIS, A GRAM -VE INTRACELLULAR BACTERIUM, IS A RECENTLY DESCRIBED (1994) EMERGING DISEASE OF PEOPLE THAT HAS NOW BEEN DESCRIBED WORLDWIDE. THE CAT FLEA IS THE CONFIRMED BIOLOGICAL VECTOR AND RESERVOIR ALTHOUGH TICKS AND MOSQUITOES CAN HARBOR R. FELIS. SINCE CLINICAL SIGNS OF FBSF ARE NON-SPECIFIC AND INFECTIONS CAN BE ASYMPTOMATIC, THERE MIGHT BE CONSIDERABLE UNDERREPORTING OF THE DISEASE. NEVERTHELESS, INFECTIONS, AS DETERMINED BY PCR OF BLOOD, ARE PARTICULARLY COMMON IN FEBRILE PATIENTS IN COUNTRIES IN AFRICA AND ASIA. TO DATE R. FELIS HAS NOT BEEN ISOLATED FROM THE BLOOD OF A FBSF PATIENT. AS A NEWLY DESCRIBED DISEASE THERE ARE MANY QUESTIONS RELATING TO FBSF, INCLUDING THE POSSIBILITY OF OTHER VECTORS, THE PATHOGENESIS AND IMMUNE RESPONSES TO INFECTION, AND EVEN AS TO WHETHER R. FELIS MIGHT NOT BE PATHOGENIC AND DETECTED ONLY AS A SYMBIONT OF A HUMAN PARASITE OR PROTOZOAN. THESE QUESTIONS WILL BE RESOLVED AS FURTHER PATIENT DATA SLOWLY ACCUMULATES AND CLINICAL TRIALS MAY BE CARRIED OUT. HOWEVER, AN APPROPRIATE ANIMAL MODEL WOULD GREATLY FACILITATE AND ACCELERATE THE INVESTIGATION OF THE UNANSWERED QUESTIONS SURROUNDING FBSF. UNFORTUNATELY, THE ONLY INFORMATION ON INFECTIONS IN ANIMALS, FROM CATS, DOGS, GUINEA PIGS, MICE, OPOSSUMS, AND RATS, INDICATE NONE ARE SUITABLE MODELS. THE MOST LIKELY ANIMAL MODEL SHOULD BE A NON-HUMAN PRIMATE (NHP) AS THEY ARE MORE CLOSELY RELATED, ANATOMICALLY AND PHYSIOLOGICALLY, TO HUMANS. TO DATE THE ONLY DATA ON R. FELIS IN NHPS IS THAT THE ORGANISM CAN BE FOUND IN THEIR FECES. THE AIM OF OUR STUDY IS TO DETERMINE IF AFRICAN GREEN MONKEYS (CHLOROCEBUS AETHIOPS SABAEUS) (AGMS) ARE SUSCEPTIBLE TO EXPERIMENTAL INFECTION (INTRAVENOUS INOCULATION) WITH THE LSU STRAIN OF R. FELIS. AFTER INFECTION, AGMS WILL BE MONITORED FOR CLINICAL SIGNS, RICKETTSEMIA BY PCR AND CULTURE, ANTIBODY RESPONSES, AND BODY ORGAN DAMAGE AND DYSFUNCTION. ONLY THE MINIMUM NUMBER OF ANIMALS REQUIRED TO MEET THE AIM OF THE STUDY WILL BE USED, AND THESE WILL BE HOUSED IN OPEN-AIR, DEDICATED FACILITIES THAT ARE INSECT-PROOF BUT CLOSELY MIRROR THEIR NATURAL ENVIRONMENT AT THE STUDY SITE ON THE CARIBBEAN ISLAND OF ST KITTS. AGMS THAT DEVELOP SEVERE SIGNS WILL BE GIVEN DOXYCYCLINE, THE ANTIBIOTIC RECOMMENDED FOR TREATMENT IN PEOPLE, WHICH WILL ENABLE A DETAILED EXAMINATION OF THE DRUG’S EFFICACY. IF AGMS DEVELOP VERY SEVERE SIGNS WITH A POOR PROGNOSIS, THEY WILL BE HUMANELY EUTHANIZED AND NECROPSIED TO DETERMINE THE PATHOGENESIS OF INFECTIONS. IF THE AGMS ARE FOUND SUSCEPTIBLE, THE DATA FROM THE STUDY WILL HELP RESEARCHERS TO DECIDE IF AGMS ARE SUITABLE MODELS OF R. FELIS INFECTIONS THAT CAN BE USED IN FUTURE PATHOGENESIS, TRANSMISSION, DIAGNOSIS, AND/OR TREATMENT STUDIES.

THE ROLE OF TUMOR-ASSOCIATED MACROPHAGE IN RECURRENT GROWTH OF TUMOR STEM CELL

SCHOLARSHIPS FOR DISADVANTAGED STUDENTS

TO IDENTIFY POTENTIAL AREAS FOR SUBMERGED AQUATIC VEGETATION.

NANOG, CANCER STEM CELLS, AND RESISTANCE TO CHEMOTHERAPY

EMSC TARGETED ISSUE GRANTS

FY 2020 CORONAVIRUS SUPPLEMENTAL FUNDING FOR HEALTH CENTERS

STRENGTHENING STROKE PREVENTION SERVICES IN UGANDA

ARRA - SCHOLARSHIPS FOR DISADVANTAGED STUDENTS

CARIBBEAN REGIONAL PROGRAM

COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - CONSTRUCTION - APPLICANT ORGANIZATION NAME: SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE ADDRESS: 801 N. RUTLEDGE AVENUE, SPRINGFIELD, IL 62794 PROJECT DIRECTOR NAME: LAURA HEPP KESSEL CONTACT PHONE / EMAIL: 309-543-2199 | LKESSEL21@SIUMED.EDU AMOUNT REQUESTED: $1,050,000 THE NATIONAL TELEHEALTH CENTER FOR ENGAGEMENT AND EDUCATION AT SIU MEDICINE WILL EMPOWER PATIENTS AND PROVIDERS WITH DIGITAL TOOLS AND STRATEGIES THAT PROMOTE THE EXCHANGE OF KNOWLEDGE AND RESOURCES RESULTING IN BETTER HEALTH FOR ALL. THE CONGRESSIONALLY DIRECTED FUNDING WILL BE USED TO BUILD A VIRTUAL TRAINING STUDIO WHERE PROGRAMS DEVELOPED BY THE CENTER CAN BE DELIVERED TO PARTICIPANTS IN RURAL COMMUNITIES THAT OTHERWISE WOULD NOT HAVE ACCESS TO THIS CONTENT. THE DELIVERY OF MEDICAL CARE VIA TELEHEALTH HAS INCREASED DRAMATICALLY OVER THE PAST 26 MONTHS HOWEVER, THERE IS STILL A NEED TO PROVIDE PATIENTS AND MEDICAL PROVIDERS MORE INFORMATION ABOUT TELEHEALTH AND RELATED PRACTICES. THE NATIONAL TELEHEALTH CENTER FOR ENGAGEMENT AND EDUCATION WILL BRIDGE THIS GAP AND FOCUS ON EDUCATING THE PUBLIC AND MEDICAL PROFESSIONALS ON THE USE OF TELEHEALTH IN CLINICAL PRACTICES. GOAL 1: BUILD OUT SPACE TO INCLUDE A VIRTUAL TRAINING STUDIO TO BE USED FOR THE DELIVERY OF TELEHEALTH PROGRAMS TO RURAL COMMUNITIES. GOAL 2: DEVELOP AND IMPLEMENT PROVIDER TELEHEALTH EDUCATION PROGRAMS - TELEHEALTH CERTIFICATE PROGRAM - MEDICAL CURRICULUM - ANNUAL TELEHEALTH CONFERENCE - ONLINE CONTINUING EDUCATION (CME) MODULES GOAL 3: DEVELOP AND IMPLEMENT PATIENT TELEHEALTH EDUCATION AND ENGAGEMENT PROGRAMS - TELEHEALTH DIGITAL HEALTH LITERACY VIDEO AND BLOG SERIES MEASURABLE OUTCOMES: 1 VIRTUAL TRAINING STUDIO COMPLETE AND OPERATIONAL # OF PROVIDERS AND STAKEHOLDERS COMPLETING CERTIFICATION COURSE # OF TELEHEALTH MEDICAL CURRICULUM LESSONS DEVELOPED # OF ECHO TELEHEALTH SESSIONS OFFERED # OF ECHO TELEHEALTH PARTICIPANTS # OF ATTENDEES AT ANNUAL TELEHEALTH CONFERENCE # OF DIGITAL HEALTH LITERACY VIDEO’S AND BL OGS CREATED # OF DIGITAL HEALTH LITERACY VIDEO’S BLOGS VIEWED # OF DIGITAL INFORMATIONAL DOCUMENTS CREATED

ADOLESCENT ANTISOCIAL BEHAVIOR & MENTAL HEALTH PROBLEMS IN HIGH-RISK PRESCHOOLERS

SCHOLARSHIPS FOR DISADVANTAGED STUDENTS

TO ENHANCE CAPACITY FOR RESEARCH, GRANT WRITING, AND PUBLICATION AMONG ECRS AND RMS AT MAKERERE UNIVERSITY THROUGH THE OPERATIONALIZATION OF THE WC BASED ON DIFFERENT MODELS IN AFRICA AND THE UNITED STATES.

COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - CONSTRUCTION - ADDRESS: 801 N. RUTLEDGE STREET, SPRINGFIELD, IL. 62702 PROJECT DIRECTOR: DR. WENDI ELLIS EL-AMIN, ASSOCIATE DEAN, EQUITY, DIVERSITY & INCLUSION CONTACT PHONE: 217-545-7334 / EMAIL ADDRESS: WEL-AMIN@SIUMED.EDU GRANT PROGRAM FUNDS REQUESTED: $1,000,000 PROJECT OVERVIEW SIU SCHOOL OF MEDICINE WILL CREATE THE REGIONAL CENTER FOR EQUITY IN PROFESSIONAL DEVELOPMENT TO ADDRESS WORKFORCE DEVELOPMENT, RESEARCH AND EDUCATION FOR BUSINESS AND COMMUNITY ORGANIZATIONS. THE GOAL IN CREATING THIS CENTER IS TO PROVIDE RESEARCHERS THE ABILITY TO COLLECT AND ANALYZE DATA ON UNDERREPRESENTED POPULATIONS IN THE WORKPLACE AND IN THE EDUCATIONAL SYSTEM. THE CENTER WILL IDENTIFY AND SHARE BEST PRACTICES IN RECRUITMENT AND RETENTION OF MARGINALIZED POPULATIONS IN OUR REGION MEASURABLE OBJECTIVES: GOAL 1: CREATE INDUSTRY-SPECIFIC EQUITY AND DIVERSITY FOCUSED PROFESSIONAL DEVELOPMENT PROGRAMS AND SERVICES. INDUSTRY INPUT AND PARTICIPATION IN STRATEGIC PLANNING PROCESS: # OF INDUSTRY SPECIFIC TRAINING PROGRAMS AND EDUCATIONAL RESOURCES DEVELOPED # OF INDIVIDUALS TRAINED BY INDUSTRY. GOAL 2: DEVELOP EDUCATIONAL PATHWAYS TO SUPPORT WORKFORCE DEVELOPMENT PROGRAMS FOR SCHOOLS AND COMMUNITY-BASED ORGANIZATIONS. -# OF WORKFORCE DEVELOPMENT PROGRAMS DEVELOPED -# OF LEARNERS RECRUITED AND TRAINED -# OF EDUCATORS AND COMMUNITY-BASED PROVIDERS TRAINED TO DELIVER WORKFORCE PROGRAMS GOAL 3: CREATION OF COMMUNITY-BASED LEARNING LABS TO PROVIDE ACCESS TO TRAINING PROGRAMS IN DIVERSE COMMUNITIES. -# OF LEARNING LABS ESTABLISHED -# OF EDUCATORS AND COMMUNITY-BASED PROVIDERS TRAINED AT EACH LAB -# OF LEARNERS TRAINED AT EACH HUB -# OF PARENTS AND ADVISORS INFORMED ABOUT PATHWAY OPPORTUNITIES GOAL 4: CREATION OF CENTER FOR EQUITY IN PROFESSIONAL DEVELOPMENT FACILITY SPACE. ESTABLISHMENT OF TRAINING CENTER INCLUDING SPACE, FURNITURE, EQUIPMENT, HOTELING SPACE FOR FACULTY, VIRTUAL TRAINING CLASSROOMS, RECORDING AND EDIT SPACE FOR FACULTY, AND SMALL GROUP SPACES. -# OF OFFICES AND TRAINING SPACES CREATED -# OF LEARNERS AND FACULTY UTILIZING THE CENTER SPACE GOAL 5: IMPROVE ACCESS TO WORKFORCE DEVELOPMENT AND PATIENT CARE THROUGH TELEHEALTH, ECHO, VIRTUAL AND ONLINE RESOURCES. -# OF WEBPAGES ESTABLISHED FOR PATHWAYS PROGRAM -# OF RESOURCES ADDED TO ONLINE REPOSITORY OF RESOURCES AND SERVICES -# OF TRAININGS HELD AND # OF LEARNERS

2019 MIDWEST AUDITORY RESEARCH CONFERENCE

TO SUPPORT FULBRIGHT CONFERENCE ON HEALTH CARE REFORM IN THE U.S. AND CHINA: DEVELOPING RESEARCH TO INFORM POLICY MAKING.

TRANSMISSION OF RICKETTSIA AFRICAE BY AMBLYOMMA AMERICANUM AND AMBLYOMMA MACULATUM

MONITORING AND EVALUATION TECHNICAL SUPPORT (METS) TO STRENGTHEN MONITORING AND EVALUATION, DISEASE SURVEILLANCE AND THE CAPABILITIES OF DISTRICT HEALTH TEAMS IN THE REPUBLIC OF UGANDA -PEPFAR

MONITORING AND EVALUATION TECHNICAL SUPPORT (METS) TO STRENGTHEN MONITORING AND EVALUATION, DISEASE SURVEILLANCE AND THE CAPABILITIES OF DISTRICT HEALTH TEAMS IN THE REPUBLIC OF UGANDA PEPFAR

FY 2023 BRIDGE ACCESS PROGRAM

CLOSEOUT DOCUMENT NUMBER

REGULATORY ROLE OF THE NF-KB PATHWAY IN LYMPHANGIOGENESIS AND BREAST CANCER METASTASIS

RESIDENCY TRAINING IN PRIMARY CARE

MONITORING AND EVALUATION TECHNICAL SUPPORT (METS) TO STRENGTHEN MONITORING AND EVALUATION, DISEASE SURVEILLANCE AND THE CAPABILITIES OF DISTRICT HEALTH TEAMS IN THE REPUBLIC OF UGANDA -PEPFAR

PCL - ALLOPATHIC MEDICINE - LOAN GRANT WITH FUNDS FOR NEW BUDGET PERIOD