Hektoen Institute For Medical Research

WOMEN'S INTERAGENCY HIV STUDY (WIHS) IV, CHICAGO CONSORTIUM

MACS/WIHS COMBINED COHORT STUDY: COOK COUNTY CLINICAL RESEARCH SITE (CC_CRS)

RYAN WHITE PART C OUTPATIENT EIS PROGRAM

RYAN WHITE TITLE IV WOMEN, INFANTS, CHILDREN, YOUTH AND AFFECTED FAMILY MEMBERS AIDS HEALTHCARE

RYAN WHITE TITLE IV WOMEN, INFANTS, CHILDREN, YOUTH AND AFFECTED FAMILY MEMBERS AIDS HEALTHCARE

RYAN WHITE PART C OUTPATIENT EIS PROGRAM

RYAN WHITE TITLE IV PROGRAM

NATIONAL CENTER ON DOMESTIC VIOLENCE, TRAUMA & MENTAL HEALTH

NATIONAL CENTER ON DOMESTIC VIOLENCE, TRAUMA & MENTAL HEALTH

FAMILY VIOLENCE PREVENTION AND SERVICES

CHICAGO ADOLESCENT TRIALS UNIT

STROGER HOSPITAL OF COOK COUNTY, DEPARTMENT OF SURGERY,*

CHICAGO PREVENTION AND INTERVENTION EPICENTER (CHICAGO PIE)

POSSE PROJECT: A COMMUNITY-LEVEL INTERVENTION FOR BLACK YMSM

TRANSGENDER YOUTH AND PREP: PK, SAFETY, UPTAKE & ADHERENCE

KEEPING IT LITE: EXPLORING HIV RISK IN VULNERABLE YOUTH WITH LIMITED INTERACTION

IMPROVING ADHERENCE AMONG HIV+ RWANDAN YOUTH: A TI-CBTE INDIGENOUS LEADER MODEL

H-STAR PROJECT: (HIV SUBSTANCE TREATMENT AND RECOVERY)

KEEPING IT LITE 2: EXPLORING HIV RISK IN VULNERABLE YOUTH WITH LIMITED INTERACTION AND DIGITAL HEALTH INTERVENTION (LITE-2) - ABSTRACT DESPITE ADVANCES IN HIV DIAGNOSTICS, CARE AND PREVENTION STRATEGIES, INFECTION RATES AMONG ADOLESCENT AND YOUNG ADULT SEXUAL AND GENDER MINORITIES (SGM) CONTINUE TO RISE IN THE UNITED STATES (US). THERE IS AN URGENT NEED TO DESCRIBE THE EPIDEMIOLOGY AND TRAJECTORIES OF HIV ACQUISITION IN THIS POPULATION AND TO OFFER AGE AND CULTURALLY APPROPRIATE SCALABLE PREVENTION INTERVENTIONS TO THOSE AT HIGHEST RISK OF INFECTION IN THE US. THIS PROJECT WILL ENGAGE AND RETAIN YOUNG SGM IN AN INNOVATIVE LONGITUDINAL COHORT, ENROLL THEM IN A DYNAMIC ESTABLISHED DIGITAL HEALTH RETENTION PLATFORM (HMP; HEALTHMPOWERMENT), MONITOR HIV RISK AND PREVENTION BEHAVIORS AND EXPLORE THE SOCIOECOLOGICAL FACTORS THAT INFLUENCE THE USE OF NEW HIV PREVENTION TECHNOLOGIES (UG3 PHASE), WHILE ALSO ALLOWING TARGETED TESTING OF NOVEL DIGITAL HEALTH INTERVENTIONS (UH3 PHASE). WE WILL ALSO TEST THE EFFICACY OF EXPANDING THE CORE VERSION OF HMP (HMP BASIC) BY ADDING ADHERENCE TOOLS (HMP ENHANCED) FOR THOSE WHO ARE ON PREP OR ART TO IMPROVE ADHERENCE AND PERSISTENCE. IN AIM 1, WE WILL ENROLL AND RETAIN A LARGE (N=6000; 3000/YEAR), DIVERSE COHORT OF SEXUALLY ACTIVE, SGM ADOLESCENTS AND YOUNG ADULTS, AGES 13-34, USING INNOVATIVE DIGITAL RECRUITMENT, ENGAGEMENT AND RETENTION STRATEGIES. OVER THE COURSE OF THE STUDY, WE WILL LONGITUDINALLY CHARACTERIZE THE SEXUAL BEHAVIOR, HIV TRANSMISSION RISK, AND PREP UPTAKE TRAJECTORIES OF SGM YOUTH UTILIZING EPIDEMIOLOGICAL TRAJECTORY ANALYSES TO IDENTIFY THE MOST EFFECTIVE POINTS OF INTERVENTION (AIM 2). FOR AIM 3, WE WILL LAUNCH A RANDOMIZED CLINICAL TRIAL TO EXAMINE THE EFFICACY OF HMP ENHANCED TO IMPROVE PREP ADHERENCE AMONG HIV-NEGATIVE YOUTH (N =750) AND ART ADHERENCE AMONG HIV-POSITIVE YOUTH (N =150) COMPARED TO HMP BASIC. FINALLY, WE WILL MAXIMIZE THE PRODUCTIVITY OF THE COHORT BY TESTING NEW AND INNOVATIVE DIGITAL HEALTH DEVICES, HIV/STI DIAGNOSTICS AND INTERVENTIONS, INFORMED BY THE PREVIOUS AIMS AS WELL AS EMERGING NIH PREVENTION PRIORITIES (AIM 4). OUR INVESTIGATIVE TEAM HAS DECADES OF EXPERIENCE WITH RECRUITMENT, PREVENTION AND CARE OF SGM YOUTH AND LARGE-SCALE LONGITUDINAL COHORT STUDIES. THIS STUDY WILL CAPITALIZE UPON PRODUCTIVE EXISTING PARTNERSHIPS AND DIGITAL HEALTH EXPERTISE TO ARTICULATE THE DRIVERS OF THE ONGOING HIV EPIDEMIC AMONG THE MOST VULNERABLE POPULATIONS IN THE US IN ORDER TO IDENTIFY THE MOST EFFECTIVE, EXPEDITIOUS AND SCALABLE STRATEGIES TO ADDRESS THIS ONGOING PUBLIC HEALTH CRISIS.

VIOLENCE AGAINST WOMEN AND SUBSTANCE USE PREVENTION INITIATIVE - THERE IS A HIGH LEVEL OF NEED FOR COORDINATED INTIMATE PARTNER VIOLENCE (IPV) AND SUBSTANCE USE DISORDER (SUD) SERVICES IN WEST VIRGINIA, PARTICULARLY FOR PREGNANT AND PARENTING WOMEN (PPW), AS EVIDENCED BY HIGH RATES OF SUBSTANCE USE, POOR INFANT AND MATERNAL HEALTH OUTCOMES, AND RACIAL DISPARITIES IN HEALTH, HEALTHCARE ACCESS AND IPV. THE PURPOSE OF THIS PROJECT IS TO CREATE A STATEWIDE PILOT INITIATIVE TO TRAIN SUBSTANCE USE DISORDER (SUD) TREATMENT PROVIDERS ON INTIMATE PARTNER VIOLENCE (IPV) AND IPV PROVIDERS ON SUBSTANCE USE AND TO ADDRESS THE INTERSECTION OF IPV AND SUD DURING THE PREGNANCY AND POSTPARTUM PERIOD. PROJECT GOALS ARE TO ENGAGE STATE AGENCIES, IPV PROGRAMS, TREATMENT PROVIDERS, AND OTHER KEY STAKEHOLDERS FROM DIVERSE COMMUNITIES IN INCREASING THE USE OF EVIDENCE-BASED AND PROMISING PRACTICES IN SERVICE DELIVERY; TO CREATE AND DELIVER TRAINING FOR SUD, IPV, AND HEALTHCARE PROVIDERS; AND TO BUILD A COLLABORATIVE STATEWIDE NETWORK OF REGIONAL TEAMS TO PROMOTE SERVICE IMPLEMENTATION AT THE LOCAL LEVEL AND ADDRESS ACCESS AND OUTCOME DISPARITIES AND UNMET NEEDS. TO ACHIEVE THESE GOALS, THE NATIONAL CENTER ON DOMESTIC VIOLENCE, TRAUMA, AND MENTAL HEALTH IS PARTNERING WITH THE WEST VIRGINIA DEPARTMENT OF HEALTH AND HUMAN RESOURCES' BUREAU FOR BEHAVIORAL HEALTH, THE WEST VIRGINIA COALITION AGAINST DOMESTIC VIOLENCE, THE WEST VIRGINIA PERINATAL PARTNERSHIP, AND THE MARSHALL UNIVERSITY RESEARCH CORPORATION’S WEST VIRGINIA BEHAVIORAL HEALTH WORKFORCE AND HEALTH EQUITY TRAINING CENTER TO ENGAGE IN SIX KEY ACTIVITIES. FIRST, WE WILL INCENTIVIZE SUD PROVIDERS TREATING PREGNANT AND POSTPARTUM WOMEN TO RECEIVE TRAINING ON IDENTIFYING IPV IN THEIR CLIENT POPULATION. SECOND, WE WILL TRAIN SUD TREATMENT PROVIDERS TO ADDRESS IPV WITH PATIENTS AND TRAIN IPV STAFF ON SUD. THIRD, WE WILL IDENTIFY RESEARCH-BASED SERVICES FOR SCREENING, ASSESSMENT, BRIEF INTERVENTION, AND REFERRAL. FOURTH WE WILL INTEGRATE IPV AND SUD PROTOCOLS INTO MEDICAL PRAC TICE. FIFTH WE WILL INTEGRATE PERINATAL AND POSTPARTUM PROGRAMS INTO EXISTING SUBSTANCE USE PROGRAMS. SIXTH, WE WILL CONDUCT PROCESS AND OUTCOMES EVALUATIONS TO DETERMINE CHANGES IN PROVIDERS' KNOWLEDGE, SKILL, AND COMFORT IN ADDRESSING IPV/SU, DOCUMENT CHANGES IN REFERRALS AND COLLABORATION AMONG STATE PARTNERS, AND ASSESS IMPROVEMENT IN IPV-SUD HEALTH OUTCOMES AMONG PREGNANT AND POSTPARTUM WOMEN. OUR APPROACH BUILDS ON WEST VIRGINIA’S EXISTING STATEWIDE PARTNERSHIPS AND NETWORKS, INCORPORATES THE PROMISING PRACTICE OF REDUCING SUBSTANCE USE COERCION, AND RESPONDS TO THE HIGH OVERDOSE AND DRUG-RELATED DEATH RATE FOR WOMEN IN WV.

THE CONTRIBUTION OF SLEEP AND CIRCADIAN DISRUPTION TO KYNURENINE PATHWAY ACTIVATION AND CARDIOMETABOLIC RISK IN WOMEN WITH HIV

POWERING UP MALE PREVENTION (PUMP)

FEASIBILITY OF AN INGESTIBLE SENSOR SYSTEM TO MEASURE PREP ADHERENCE IN YMSM

CHICAGO ANTIMICROBIAL RESISTANCE AND INFECTION PREVENTION EPI-CENTER (CARPE)

RYAN WHITE CARE ACT TITLE IV ADOLESCENT INITIATIVE

PRIMARY CARE TRAINING AND ENHANCEMENT

HEALTH CARE AND OTHER FACILITIES

SPECIAL PROJECTS OF NATIONAL SIGNIFICANCE

FVPSA AMERICAN RESCUE PLAN COVID-19 TESTING, VACCINES, AND MOBILE HEALTH UNITS SUPPLEMENTAL FUNDING

FAMILY VIOLENCE PREVENTION AND SERVICES PROGRAM

SPECIAL PROJECTS OF NATIONAL SIGNIFICANCE

TRUST IN HEALTH CARE AND RACIAL DISPARITIES IN AN AGING POPULATION

KEEPING IT LITE: EXPLORING HIV RISK IN VULNERABLE YOUTH WITH LIMITED INTERACTION

FACULTY DEVELOPMENT IN PRIMARY CARE

FY2021 FVPSA ARP ACT SUPPLEMENTAL

COMPUTER ASSISTED QUALITY OF LIFE AND SYMPTOM ASSESSMENT OF COMPLEX PATIENTS

ARRA - TRAINING IN PRIMARY CARE MEDICINE AND DENTISTRY: RESIDENCY TRAINING IN PRIMARY CARE

PREVENTIVE MEDICINE RESIDENCIES

MENTAL HEALTH, TRAUMA AND EMPLOYMENT TA PROJECT

AN HIV INTERVENTION TAILORED FOR BLACK YMSM IN THE HOUSE BALL COMMUNITY

POWERING UP MALE PREVENTION (PUMP)

TRAINING AND TA ON THE INTERSECTION OF VIOLENCE AGAINST WOMEN AND SUBSTANCE ABUSE: COLLABORATIVE STRATEGIES FOR IMPROVING SAFETY AND RECOVERY

NT'L TRAINING & TECH. ASSIST. CENTER ON D.V. TRAUMA AND MENTAL HEALTH

INCREASING ACCESS TO VICTIM SERVICES FOR VICTIMS OF DOMESTIC VIOLENCE AND SEXUAL ASSAULT WHO HAVE A SERIOUS MENTAL ILLNESS

MEASURING HEALTH-RELATED TRUST IN DIVERSE POPULATIONS

PRIMARY CARE TRAINING AND ENHANCEMENT

SPECIAL PROJECTS OF NATIONAL SIGNIFICANCE

#CHOPVIOLENCE/#CHOPHIV: A TAILORED VIOLENCE PREVENTION INTERVENTION FOR BLACK YOUNG MSM AND TRANSGENDER WOMEN FROM THE HOUSE BALL COMMUNITY TO IMPROVE HIV OUTCOMES AND DECREASE EXPOSURE TO VIOLENCE

RYAN WHITE HIV/AIDS PROGRAM PART C EIS COVID-19 RESPONSE

RYAN WHITE TITLE III HIV CAPACITY DEVELOPMENT AND PLANNING GRANTS - THE RUTH M. ROTHSTEIN CORE CENTER (CORE CENTER) IS A CRITICAL PROVIDER OF PRIMARY MEDICAL AND SUPPORTIVE SERVICES TO PEOPLE LIVING WITH HIV/AIDS (PLWHA) THROUGHOUT THE CHICAGO ELIGIBLE METROPOLITAN AREA (EMA). CORE CENTER IS PART OF THE COOK COUNTY HIV INTEGRATED PROGRAM (CCHIP) AND COOK COUNTY HEALTH (CCH), THE LARGEST SAFETY NET HEALTHCARE PROVIDER FOR CHICAGO AND COOK COUNTY. IN 2021, THE CORE CENTER PROVIDED 14,733 AMBULATORY VISITS TO 4,683 UNDUPLICATED CLIENTS AND 11,133 VISITS FOR MEDICAL SUBSPECIALTY CARE TO MORE THAN 3,300 CLIENTS. ACCORDING TO THE ILLINOIS DEPARTMENT OF PUBLIC HEALTH (IDPH), THE BURDEN OF HIV/AIDS IN THE STATE OF ILLINOIS IS MOST CONCENTRATED IN THE NINE-COUNTY CHICAGO EMA, WHICH INCLUDES THE CITY OF CHICAGO. AS OF DECEMBER 31, 2020, 80% OF ALL PLWHA IN ILLINOIS RESIDE IN THE CHICAGO EMA, WITH 66% IN THE CITY OF CHICAGO. THIS AREA IS ALSO HOME TO THE MAJORITY OF AFRICAN AMERICAN AND HISPANIC PLWHA: 84% OF AFRICAN AMERICAN PLWHA AND 88% OF HISPANIC PLWHA. THIS PROPOSAL SEEKS $150,000 FOR A ONE-YEAR INNOVATIVE PROJECT TO ENHANCE AND EXPAND OUR PEER NAVIGATOR PROGRAM AT CORE CENTER. THE AIM IS TO DEVELOP A VIRTUAL COMMUNITY HEALTH WORKER (CHW) PROGRAM AND RECRUIT CLIENTS TO PARTICIPATE TO GAIN SKILLS TOWARD WORKFORCE DEVELOPMENT. THIS FUNDING WOULD ALLOW THE NEWLY FORMED “SEXUAL HEALTH AMBASSADOR PROGRAM EMPOWERED” INITIATIVE OR “S.H.A.P.E. PROGRAM TO EXPAND AND CONTINUE BEYOND ITS CURRENT SHORT-TERM ENDING THE HIV EPIDEMIC (EHE) FUNDING WHICH ENDS FEBRUARY 2022. S.H.A.P.E. IS A "YOUTH SEXUAL HEALTH AMBASSADOR PROGRAM" AIMED AT RECRUITING YOUNG MSM AND TRANSGENDER HIV POSITIVE PATIENTS OF COLOR WHO ARE DISPROPORTIONATELY IMPACTED BY HIV/AIDS. THE PROJECT GOALS ARE TO: TO POSITIVELY IMPACT THE OVERALL SEXUAL HEALTH OUTCOMES OF YOUNG ADULTS OF COLOR AGES 18-25 AS WE ENGAGE, EDUCATE, AND EMPOWER YOUTH TO ACCESS PRIMARY CARE, PREVENTIVE SEXUAL HEALTH SERVICES INCLUDED BY NOT LIMITED TO EDUCATION, SCREENING, AND TR EATMENT OF HIV AND OTHER STI'S. WITH THIS FUNDING, WE WILL MERGE OUR EXISTING PEER NAVIGATION PROGRAM WITH THE S.H.A.P.E. INITIATIVE TO FORM A NEW CHW PROGRAM.

RYAN WHITE TITLE III HIV CAPACITY DEVELOPMENT AND PLANNING GRANTS

RYAN WHITE HIV/AIDS PROGRAM PART D WICY COVID-19 RESPONSE

RYAN WHITE TITLE III HIV CAPACITY DEVELOPMENT AND PLANNING GRANTS

SPECIAL PROJECTS OF NATIONAL SIGNIFICANCE

SPECIAL PROJECTS OF NATIONAL SIGNIFICANCE

CHICAGO INITIATIVE TO RAISE ASTHMA HEALTH EQUITY

TOXIC PREGNANCY: CONFERENCE ON EFFECTS OF ENVIRONMENTAL TOXICANT EXPOSURE IN PREG

PREVENTIVE MEDICINE RESIDENCIES

SPECIAL PROJECTS OF NATIONAL SIGNIFICANCE

SPECIAL PROJECTS OF NATIONAL SIGNIFICANCE