Sinai Health System

IMMUNOBIOLOGY OF PEANUT ALLERGY AND ITS TREATMENT: A PROTOTYPE

MSHS TRANSLATIONAL SCIENCE HUB

ALZHEIMER'S DISEASE RESEARCH CENTER

DRUG COMBINATION SIGNATURES FOR PREDICTION AND MITIGATION OF TOXICITY

A NEW DISEASE PLATFORM LEVERAGING COMPLEX DROSOPHILA AND MAMMALIAN MODELS

CANNABIDIOL IN THE TREATMENT OF OPIOID USE DISORDER

SOMATIC MOSAICISM IN SCHIZOPHRENIA AND CONTROL BRAINS

MOLECULAR PROFILING OF SCHIZOPHRENIA

IN VIVO MOLECULAR MRI OF ATHEROTHROMBOTIC LESIONS

UNDERSTANDING GENE X STRESS INTERACTIONS ACROSS THE CELL TYPES OF THE BRAIN IN PTSD

MOUNT SINAI INJURY CONTROL RESEARCH CENTER (MS-ICRC)

IDENTIFICATION OF IBD SUSCEPTIBILITY GENES

MODELING CELL REGULATORY NETWORKS

GMP PRODUCTION OF CANDIDATE PAN-GROUP 2 INFLUENZA A VIRUS

MODEL OF HUMAN DISC REGENERATION IN THE SPECTRUM OF DEGENERATIVE DISC DISEASE

MOLECULAR STUDIES OF COCAINE ACTION IN BRAIN

MONOCLONAL THYROID STIMULATING ANTIBODIES

BIOMEDICAL IMAGE ENGINEERING OF MACULAR IMAGES

SYSTEMS BIOLOGY BASED PROTEOGENOMIC TRANSLATOR FOR CANCER MARKER DISCOVERY TOWARDS PRECISION MEDICINE

ENZYMES INVOLVED IN NEUROPEPTIDE BIOSYNTHESIS AND REGULATION

SURGICAL IIH TREATMENT TRIAL

INVESTIGATING GENOMIC FACTORS AND MICROBIOME FEATURES THAT IMPACT CDI TRANSMISSION AND PROGNOSIS

AGE-RELATED TAUOPATHY IN HIV-ASSOCIATED NEUROCOGNITIVE DISORDERS

MOLECULAR CHARACTERIZATION AND VALIDATION OF GENDER DIFFERENCES IN ALZHEIMERS DISEASE PATHOGENESIS

MECHANISMS OF STRUCTURAL PLASTICITY IN STRESS-RELATED DISORDERS

SYSTEMATIC DRUG REPURPOSING TARGETING IMMUNE ACTIVATION NETWORKS IN ALZHEIMER'S DISEASE (AD)

ROLE OF MICRORNAS IN THE MECHANISMS OF DRUG DEPENDENCE

ROLE OF HIPK2 IN KIDNEY TUBULOINTERSTITIAL INJURY

THRESHOLD OF COGNITIVE IMPAIRMENT AFTER HIV INFECTION: EFFECT OF MORPHINE

SYSTEMATIC LIGHT EXPOSURE FOR FATIGUE IN STEM CELL TRANSPLANT SURVIVORS

DEVELOPMENT OF NOVEL THERAPEUTICS FOR OPIOID DEPENDENCE

RNA EXPRESSION IN PTSD IN INDUCED HUMAN NEURONS AND BLOOD CELLS IN BASAL AND GLUCOCORTICOID-STIMULATED CONDITIONS

HYBRID CORONARY REVASCULARIZATION TRIAL- DCC

INTEGRATIVE GENOMIC ANALYSES OF MACROPHAGES IN CROHNS DISEASE

TRANSCRIPTOME ATLASES OF THE CRANIOFACIAL SUTURES

MOLECULAR PATHOGENESIS OF INTESTINAL SERRATED POLYPS

MSHS TRANSLATIONAL SCIENCE HUB

THE ROLE OF KLF6 IN HEPATIC FIBROSIS

MECHANISMS FOR INCREASED BREAST CANCER RISK IN TYPE 2 DIABETES

WNT SIGNALS IN SKIN AND HAIR DEVELOPMENT AND HAIR GROWTH

2/2-A LARGE-SCALE SCHIZOPHRENIA ASSOCIATION STUDY IN SWEDEN

PREVENTION OF THE CARDIOVASCULAR MEDICAL CONSEQUENCES OF DRUG OVERDOSE

TOWARDS A COMPREHENSIVE SIGNALING PATHWAY MAP OF PARAHIPPOCAMPAL VULNERABILITY IN ALZHEIMERS DISEASE

CNS RESERVOIRS OF HIV IN A MOUSE MODEL OF HIV INFECTION AND COGNITIVE IMPAIRMENT:

GLUCOCORTICOIDS & ADIPOCYTE FUNCTION IN HUMAN OBESITY

THERAPEUTIC MECHANISMS OF CARDIAC PROGENITORS IN ISCHEMIC CARDIOMYOPATHY

SUMO1 AND SERCA2A FUNCTION

ANTI-AAV ANTIBODIES AS AN OBSTACLE TO CARDIAC AAV GENE THERAPY

RYAN WHITE PART C OUTPATIENT EIS PROGRAM

COMPARATIVE EFFECTIVENESS OF LIMITED RESECTION VS. STEREOTACTIC BODY RADIATION THERAPY FOR EARLY STAGE LUNG CANCER

DISSECTING SPLICING FACTOR MUTATIONS IN IPSCS

MICRORNA & BREAST CANCER: FUNCTIONAL CHARACTERIZATION IN A POPULATION-BASED STUDY

OBESITY AND ASTHMA: UNVEILING METABOLIC AND BEHAVIORAL PATHWAYS

INSULIN RESISTANCE AND BREAST CANCER PROGNOSIS IN BLACK & WHITE WOMEN

OOCYTE POLARITY AND MRNA LOCALIZATION IN ZEBRAFISH

INTEGRATED MULTISCALE NETWORKS IN SCHIZOPHRENIA

COMMUNITY HEALTH WORKER TRAINING PROGRAM - ADDRESS: 1501 S FAIRFIELD, CHICAGO, IL 60608-1782 PROJECT DIRECTOR: STACY IGNOFFO OFFICE PHONE NUMBER: 773-257-2745 EMAIL ADDRESS: STACY.IGNOFFO@SINAI.ORG WEBSITE ADDRESS: HTTPS://WWW.SINAICHICAGO.ORG/EN/ REQUESTED FUNDS: $2,999,989.67 PROJECT OVERVIEW: OUR PROJECT OFFERS COLLABORATIONS WITH LOCAL WORKFORCE DEVELOPMENT, EMPLOYER, COMMUNITY-BASED, COMMUNITY HEALTH WORKER (CHW) COALITIONS, PUBLIC HEALTH, ACADEMIC AND HEALTH SYSTEM PARTNERS TO ENHANCE AND EXPAND INNOVATIVE, COLLABORATIVE, AND COMMUNITY-ENGAGED CHW WORKFORCE DEVELOPMENT APPROACHES TO MEET THE UNIQUE NEEDS OF COMMUNITIES AND THE STAKEHOLDERS SERVING THEM. OVER THE COURSE OF THREE YEARS, SINAI URBAN HEALTH INSTITUTE (SUHI) WILL RECRUIT AND TRAIN 240 NEW AND INCUMBENT CHWS FROM SOUTH SIDE OF CHICAGO AND THE WESTERN COOK COUNTY SUBURBS OF CHICAGO ON CORE COMPETENCY SKILLS AND ADVANCED CHW SPECIALIZATION TOPICS SUCH AS BEHAVIORAL HEALTH, HEALTH EDUCATION, AND SYSTEM NAVIGATION. SUHI SEEKS TO EXPAND THE CHW WORKFORCE AND SUPPORT ESSENTIAL PUBLIC HEALTH SERVICES BY DEVELOPING EXPERIENTIAL LEARNING, ON THE JOB TRAINING, APPRENTICESHIPS, AND EMPLOYMENT OPPORTUNITIES. STAFFING INCLUDES FOUR KEY STAFF: THE PROJECT DIRECTOR, A SENIOR ADVISOR, A SENIOR MANAGER, AND AN EVALUATOR CURRENTLY ON STAFF. WE WILL ENGAGE FOUR NEW STAFF: A PROGRAM COORDINATOR, BUSINESS SERVICES LIAISON, CAREER COACH, AND A DIGITAL LITERACY INSTRUCTOR. THE GOALS AND OBJECTIVES ALIGN WITH THE PROGRAM GOALS AND PROGRAM OBJECTIVES OUTLINED IN THE NOFO. IN ORDER TO ACHIEVE OUR GOALS OF (1) EXPANDING, (2) EXTENDING, AND UPSKILLING THE PUBLIC HEALTH WORKFORCE; (3) INCREASING CHW EMPLOYMENT READINESS; AND (4) ADVANCING HEALTH EQUITY AND SUPPORT FOR UNDERSERVED COMMUNITIES, WE HAVE IDENTIFIED THE FOLLOWING OBJECTIVES: 1.A. ESTABLISH EDUCATIONAL TRAINING CURRICULA AND RECRUIT, TRAIN AND ENABLE NEW CHWS CANDIDATES TO ACQUIRE CORE COMPETENCIES FOR CHWS AND PUBLIC HEALTH CERTIFICATIONS THAT FOLLOW STATE, LOCAL, OR ENTITY GUIDELINES AN D SUPPORT ESSENTIAL PUBLIC HEALTH SERVICES 1.B. REDUCE BARRIERS TO CHW PROGRAM ENROLLMENT AND RETENTION BY PROVIDING ELIGIBLE TRAINEES WITH PARTICIPANT SUPPORT 2.A. PROVIDE ADDITIONAL TRAINING FOR CURRENT CHWS TO INCLUDE THE CORE COMPETENCIES FOR PUBLIC HEALTH AND ESSENTIAL PUBLIC HEALTH SERVICES. 2.B. DEVELOP OR ENHANCE TRAINEE CURRICULUM AROUND EVIDENCE-BASED CORE COMPETENCIES FOR PUBLIC HEALTH, INCLUDING BUT NOT LIMITED TO EMERGENCY RESPONSE EDUCATION, PREVENTION, TREATMENT, AND VACCINE HESITANCY RESEARCH. 3.A. IMPLEMENT HANDS-ON CHW INTEGRATED TRAINING THROUGH COMMUNITY-BASED PARTNERSHIPS THAT PROVIDE FIELD PLACEMENTS IN UNDERSERVED COMMUNITIES. 3.B. PROVIDE JOB PLACEMENT SERVICES AND ON-THE-JOB EXPERIENTIAL TRAINING TO NEW CHWS THROUGH DEPARTMENT OF LABOR OR STATE/LOCAL REGISTERED APPRENTICESHIP PROGRAMS. 4.A. ASSESS AND ADDRESS CRITICAL GAPS IN PUBLIC HEALTH AND COMMUNITY NEEDS THAT CAN BE FILLED BY CHWS IN COMMUNITIES THAT ARE DISPROPORTIONATELY BURDENED BY COVID-19, HEALTH INEQUITIES, LIMITED ACCESS TO TECHNOLOGY, AND SOCIAL DETERMINANTS OF HEALTH (SDOH). 4.B. INCREASE THE DISTRIBUTION AND DIVERSITY OF THE CHW WORKFORCE BY RECRUITING, TRAINING, OR EMPLOYING, AS APPLICABLE, INDIVIDUALS WHO WILL SERVE IN UNDERSERVED COMMUNITIES AS INTEGRAL MEMBERS OF INTEGRATED CARE TEAMS. THESE OBJECTIVES WERE DEVELOPED IN RESPONSE TO THE CURRENT GAPS IN THE CHW WORKFORCE; THEY AIM TO PROVIDE PERSONALIZED CHW TRAINING AND SUPPORT, COMPREHENSIVE RECRUITMENT STRATEGIES, STRONG MENTORSHIPS, AND CLEAR PATHWAYS TO SUSTAINABLE CAREERS. WE WILL NOT REQUEST A FUNDING PREFERENCE ALTHOUGH THROUGH TWO FUNDED PROJECTS, SUHI IS TRAINING INDIVIDUALS WHO ARE FROM DISADVANTAGED BACKGROUNDS TO JOIN THE PUBLIC HEALTH WORKFORCE. FROM 2020-2022, THE COVID-19 RESPONSE CORPS SERVED A TOTAL OF 809 INDIVIDUALS. WE DO NOT HAVE ALL THE INFORMATION NEEDED TO SATISFY QUALIFICATION #2. OUR TOTAL REQUEST IS $2,999,999.

ROLE OF THE P53 C-TERMINAL DOMAIN IN TISSUE HOMEOSTASIS, TUMOR SUPPRESSION, AND ONCOGENESIS

MULTI-LEVEL ANALYSIS OF INFLUENZA VIRUS POLYMERASE AND ITS ROLE IN PATHOGENESIS

IMPACT OF WTC DUST ON IMMUNE FUNCTIONS AND PROSTATE CANCER PROMOTION

ASSESSING INFLAMMATORY AND BEHAVIORAL PATHWAYS LINKING PTSD TO INCREASED ASTHMA MORBIDITY IN WTC WORKERS

OPTIMIZING TREATMENT OF LUNG CANCER PATIENTS WITH COMORBIDITIES

REWARD SYSTEMS AND FOOD AVOIDANCE IN ADOLESCENTS WITH LOW WEIGHT EATING DISORDERS

THYROTROPIN RECEPTOR, THYROTROPIN AND MECHANISMS OF BONE LOSS

REALIZATION OF OPTICAL CELL-BASED REPORTERS FOR IN VIVO DETECTION OF NEUROPEPTIDES

EFFECTS OF PS1FAD MUTATIONS ON PS1-NMDAR ASSOCIATION, NECROPTOSIS AND ELECTROPHYSIOLOGY.

TROPISM, PATHOGENICITY, AND POTENTIAL FOR ZOONOTIC SPILLOVER OF EMERGENT HENIPA- AND HENIPA-LIKE VIRUSES

DIABETES INDUCED DISC DEGENERATION AND PREVENTION

NOTOCHORDAL CELL DERIVED THERAPIES FOR PAINFUL DISC DEGENERATION

A SYSTEMS BIOLOGY APPROACH FOR DISSECTING ENHANCER HIERARCHY

BIOGRID: AN OPEN RESOURCE FOR BIOLOGICAL INTERACTIONS AND NETWORK ANALYSIS

CARDIOVASCULAR INFLAMMATION REDUCTION TRIAL (CIRT) - INFLAMMATION IMAGING STUDY

TOWARDS AN INTEGRATED ANALYTICS SOLUTION TO CREATING A SPATIALLY-RESOLVED SINGLE-CELL MULTI-OMICS BRAIN ATLAS - PROJECT SUMMARY THE MAINTENANCE AND FUNCTION OF THE NERVOUS SYSTEM DEPENDS ON CELL-CELL INTERACTIONS AMONG NEURONAL AND NON-NEURONAL CELL POPULATIONS, WHICH OCCUR THROUGH PHYSICALLY BINDING CELL MEMBRANE SURFACE OR SECRETED PROTEINS, TRIGGERING SIGNALING CASCADES THAT ACTIVATE CELL-TYPE GENE REGULATORY PROGRAMS. THE CELL-CELL INTERACTOME RESPONDS AND REGULATES THE MICROENVIRONMENT WHICH IS ALTERED IN PHYSIOLOGICAL PROCESSES SUCH AS BRAIN DEVELOPMENT AND AGING, OR DURING THE ONSET AND PROGRESSION OF DIFFERENT NEUROPSYCHIATRIC DISORDERS. ALTHOUGH GREAT PROGRESS HAS BEEN MADE IN DISSECTING CELLULAR HETEROGENEITY THROUGH SINGLE-CELL TRANSCRIPTOME AND EPIGENOME PROFILING, A SPATIAL ATLAS DECIPHERING THE GENE REGULATORY PROGRAMS THAT MEDIATE CELL-CELL INTERACTIONS AMONG NEURONAL AND NON-NEURONAL CELL POPULATIONS IN THE HUMAN NERVOUS SYSTEM IS LACKING. NEW TECHNOLOGIES HAVE BEEN DEVELOPED TO GENERATE TRANSCRIPTOME-SCALE GENE EXPRESSION PROFILES WITH HIGH SPATIAL RESOLUTION IN THE ORIGINAL TISSUE CONTEXT, THUS GREATLY FACILITATING THE STRUCTURAL CHARACTERIZATION OF THE TISSUE MICROENVIRONMENT AS WELL AS MECHANISTIC INVESTIGATION OF CELL-CELL INTERACTIONS. SPATIAL TRANSCRIPTOMICS TECHNOLOGIES ARE INCREASINGLY USED BY THE NIH BRAIN RESEARCH THROUGH ADVANCING INNOVATIVE NEUROTECHNOLOGIES (BRAIN) INITIATIVE AND VIEWED AS AN IMPORTANT COMPONENT OF THE CELL ATLAS BUILDING EFFORT. INTEGRATIVE ANALYSES OF SPATIAL TRANSCRIPTOMICS AND MULTI-OMIC DATA HAVE GREAT POTENTIAL IN CONSTRUCTING A COMPLETE SPATIALLY RESOLVED BRAIN ATLAS. HOWEVER, IT REMAINS CHALLENGING TO SYSTEMATICALLY ANALYZE, COMPARE, AND INTEGRATE DATA GENERATED BY DIFFERENT GROUPS, IN PART DUE TO THE SIGNIFICANT VARIATION IN TECHNOLOGY PLATFORMS AND DATA ANALYSIS PIPELINES. IN PREVIOUS WORK, OUR LAB HAS DEVELOPED GIOTTO AS A POWERFUL TOOLBOX FOR COMPREHENSIVE SPATIAL TRANSCRIPTOMICS ANALYSIS. IN THIS PROJECT, WE PROPOSE TO USE GIOTTO AS THE BASIS TO CREATE A CLOUD-BASED SOFTWARE PLATFORM AND FURTHER DEVELOP NEW PIPELINES TO FACILITATE HARMONIZING AND INTEGRATING BRAIN INITIATIVE DATASETS. THE SPECIFIC AIMS ARE: 1. TO DEVELOP A CLOUD-BASED SOFTWARE PLATFORM FOR HARMONIZING SPATIAL TRANSCRIPTOMICS DATA ANALYSIS AND VISUALIZATION; 2. TO ELUCIDATE THE GENE REGULATORY NETWORKS MEDIATING CELL- CELL INTERACTIONS IN THE BRAIN THROUGH INTEGRATED SPATIAL MULTI-OMIC ANALYSIS; AND 3. TO CREATE A BENCHMARK SYSTEM FOR OBJECTIVE EVALUATION OF SPATIAL TRANSCRIPTOMICS TECHNOLOGIES AND DATA ANALYSIS PIPELINES. TAKEN TOGETHER, OUR PROPOSED RESEARCH WILL GENERATE POWERFUL COMPUTATIONAL TOOLS THAT WILL NOT ONLY HELP BRAIN INITIATIVE INVESTIGATORS TO CONSTRUCT A SPATIALLY RESOLVED BRAIN ATLAS BUT ALSO ENABLE THE BROAD COMMUNITY TO EFFICIENTLY UTILIZE THE RICH RESOURCES GENERATED BY THE BRAIN INITIATIVE IN THEIR OWN RESEARCH.

MOUSE MODELS FOR SYSTEMS THERAPEUTICS DEGENERATIVE DISEASES

MOLECULAR METHODS TO IMPROVE CERVICAL CANCER SCREENING IN HIV+ WOMEN

REGULATION OF ADULT VISUAL CORTEX PLASTICITY BY ENDOGENOUS NICOTINIC MODULATORS

TRAJECTORY OF RECOVERY IN THE ELDERLY

LATE-LIFE CONSEQUENCES OF TBI AND MILITARY SERVICE: A POPULATION-BASED STUDY

STRUCTURAL AND FUNCTIONAL NEUROIMAGING OF POST TRAUMATIC STRESS DISORDER AND COGNITIVE IMPAIRMENT IN WORLD TRADE CENTER RESPONDERS

HEPATOTOXIC EXPOSURES, PROGRESSIVE FATTY LIVER DISEASE (NASH), AND LIVER CANCER RISK IN THE WORLD TRADE CENTER HEALTH PROGRAM GENERAL RESPONDER COHORT

FEAR LEARNING AND RECONSOLIDATION AFTER TRAUMA EXPOSURE A COMPUTATIONAL APPROACH

NOVEL TOOLS TO MAXIMIZE PROFILING OF TISSUE AND ANTIGEN SPECIFIC IMMUNE DYSREGULATION IN ALLERGY AND INFLAMMATORY BOWEL DISESASE

THE BIOLOGY OF THE NUCLEAR EXPORT PROTEIN IN INFLUENZA A VIRUS REPLICATION

HIV RESTRICTION BY APOBEC3A

TISSUE-SPECIFIC TUMOR SUPPRESSOR EFFECTS OF P53

OPTIMIZING LUNG CANCER TREATMENT IN HIV INFECTED PERSONS

NORADRENERGIC CIRCUIT MECHANISMS OF PERSISTENT FEAR

MOLECULAR BASES OF LEUCINE RICH REPEAT KINASE 2 ACTIVITY REGULATION

GENETICS OF CONOTRUNCAL DEFECTS AND ASSOCIATED NEURODEVELOPMENTAL OUTCOMES

MOUNT SINAI SPINAL CORD INJURY MODEL SYSTEMS

METHODS FOR MULTISCALE AND INTEGRATIVE CHARACTERIZATION OF BACTERIAL EPIGENOMES

BRAIN CONNECTIVITY AND THE ROLE OF MYELIN IN PSYCHOSIS

NEURODEVELOPMENTAL PHENOTYPES IN MLL MUTANT MICE

SUMO AND UBIQUITIN MODIFICATIONS IN HENIPAVIRUS MATRIX TRAFFICKING AND FUNCTION

TOWARD THERAPEUTIC MANIPULATION OF ENDOTHELIAL TO MESENCHYMAL TRANSITION

CELL MIGRATION AND VIROLOGICAL SYNAPSE FORMATION IN PARENTERAL HIV TRANSMISSION

HOSPITAL QUALITY AND RACIAL/ETHNIC DISPARITIES IN SEVERE MATERNAL MORBIDITY

NOVEL PATHOPHYSIOLOGICAL INSIGHTS INTO MITOCHONDRIAL FATTY ACID OXIDATION DISORDERS

THERAPEUTIC MECHANISMS OF HUMAN CD34 EXOSOMES

MECHANISMS UNDERLYING PREDICTORS OF SUCCESS FROM OBESITY SURGERY

NURSING WORKFORCE DIVERSITY

MECHANISMS OF TGFBETA AND SMAD SIGNALING IN TENDON REGENERATION AND FIBROSIS

CHRONIC INHIBITION OF ANDROGEN RECEPTOR SIGNALING LEADS TO NEUROENDOCRINE PROSTATE CANCER BY TRANS DIFFERENTIATION OF STEM/PROGENITOR CELLS

COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - CONSTRUCTION

BIG OMICS DATA ENGINE 2 SUPERCOMPUTER

THE IMMUNE CELL ATLAS ? A ROBUST FRAMEWORK TO MAP THE ENTIRE HUMAN IMMUNE SYSTEM

QUANTIFYING ENVIRONMENTAL VARIABLES AFFECTING AIRBORNE INFLUENZA TRANSMISSION

CDH8-DEPENDENT CIRCUIT DEVELOPMENT IN AUTISM

DEVELOPING THERAPEUTICS AGAINST RESISTANCE TO THE ANDROGEN-DEPRIVATION THERAPY

LIPIDOMICS: A NOVEL TOOL TO DEFINE HUMAN PLACENTAL DEVELOPMENT AND FUNCTION ACROSS PREGNANCY

MECHANISMS OF ADPKD CYSTOGENESIS

THE ROLE OF DENDRIN IN GLOMERULAR DISEASE PROGRESSION

AN INTRONIC LOCUS DETERMINES SHROOM3-EXPRESSION AND POTENTIATES RENAL ALLOGRAFT FIBROSIS

NICOTINIC RECEPTORS AND ALCOHOL REINFORCEMENT

MECHANISM OF AUTOIMMUNE HEPATITIS DEVELOPMENT IN A NOVEL MOUSE MODEL

ROLE OF SOD1 IN CANCER

TENDON-DEPENDENT CONTROL OF LONGITUDINAL BONE GROWTH

HIGH RESOLUTION CHARACTERIZATION OF GUT MICROBIOME AND ITS RESPONSE TO ANTIBIOTICS

NEW EPIGENETIC GENE SILENCING TECHNOLOGY

THE NEW YORK CITY COLLABORATIVE REGIONAL COORDINATING STROKE CENTER

CONDUITS: MSHS TRANSLATIONAL SCIENCE HUB

EXPANDING ACCESS TO TRAUMA AND GRIEF SERVICES FOR SOUTHWEST SIDE CHICAGO YOUTH - SUMMARY: THIS PROJECT WILL EXPAND SINAI HEALTH SYSTEM’S CAPACITY TO PROVIDE EFFECTIVE TRAUMA- AND GRIEF-FOCUSED TREATMENT FOR CHILDREN, ADOLESCENTS, AND THEIR FAMILIES, WHO EXPERIENCE TRAUMATIC EVENTS ON THE SOUTHWEST SIDE OF CHICAGO, WITH A FOCUS ON INDIVIDUALS WHO IDENTIFY AS LESBIAN, GAY, BISEXUAL, TRANSGENDER, QUEER/QUESTIONING, INTERSEX, ASEXUAL, OR ANY OTHER GENDER EXPRESSION/IDENTITY (LGBTQIA+). SINAI’S BEHAVIORAL HEALTH (BH) DEPARTMENT WILL WORK WITH CHILD-SERVING INSTITUTIONS TO PROVIDE DIRECT EVIDENCE-BASED MENTAL HEALTH TREATMENT AND SERVICES INCLUDING SCREENING, DIAGNOSTIC ASSESSMENT, CARE MANAGEMENT, THERAPY, AND PREVENTION FOR AT-RISK CHILDREN AND ADOLESCENTS IN HOLY CROSS HOSPITAL’S CASIMIR CLINIC, AN OUTPATIENT ASSESSMENT AND TREATMENT PROGRAM WHICH TREATS CHILDREN, ADOLESCENTS, AND THEIR FAMILIES. TITLE: EXPANDING ACCESS TO TRAUMA AND GRIEF SERVICES FOR SOUTHWEST SIDE CHICAGO YOUTH POPULATION & DEMOGRAPHICS: THE GEOGRAPHIC CATCHMENT AREA WILL BE THE SERVICE AREA FOR HOLY CROSS HOSPITAL (HCH) WHICH INCLUDES 14 COMMUNITY AREAS ACROSS SEVEN ZIP CODES ON THE SOUTHWEST SIDE OF CHICAGO. THIS SERVICE AREA HAS A HARDSHIP INDEX SCORE OF 86 (OUT OF 100), INDICATING THAT THE COMMUNITIES FACE INCREASED HARDSHIP IN TERMS OF EMPLOYMENT, HOUSING, EDUCATION, AND POVERTY; FACTORS THAT ARE HIGHLY CORRELATED WITH POOR MENTAL AND PHYSICAL HEALTH. THE POPULATION OF FOCUS WILL BE UNDERSERVED AND UNDER-RESOURCED CHILDREN, ADOLESCENTS, AND THEIR FAMILIES WHO HAVE EXPERIENCED TRAUMA AND TRAUMATIC EVENTS. WITHIN OUR SERVICE AREAS, THIS POPULATION IS PREDOMINANTLY BLACK/AFRICAN AMERICAN (53%) AND BETWEEN 18 AND 40 YEARS OLD (46%). GOALS & OBJECTIVES: GOAL 1: INCREASE CAPACITY OF SINAI’S BEHAVIORAL HEALTH (BH) OUTPATIENT CLINIC TO PROVIDE EFFECTIVE TRAUMA- AND GRIEF-FOCUSED TREATMENT AND SERVICE SYSTEMS FOR CHILDREN, ADOLESCENTS, AND THEIR FAMILIES WHO EXPERIENCE TRAUMATIC EVENTS. 1.1. BY SEPTEMBER 29, 2028, SINAI’S BH DEPARTMENT WILL ENROLL 540 NEW YOUTH PATIENTS INTO THEIR BH OUTPATIENT CLINIC. 1.2 BY SEPTEMBER 29, 2028, 25% OF PATIENTS AT HOLY CROSS’S BH OUTPATIENT CLINIC WILL EXPERIENCE AN INCREASE IN STRENGTHS ONE YEAR AFTER THEIR INITIAL ASSESSMENT. 1.3 BY SEPTEMBER 29, 2028, 40% OF PATIENTS AT HOLY CROSS’S BH OUTPATIENT CLINIC WILL EXPERIENCE A DECREASE IN TRAUMA-RELATED SYMPTOMS ONE YEAR AFTER THEIR INITIAL ASSESSMENT. GOAL 2: INCREASE ACCESS TO EVIDENCE-BASED TRAUMA- AND GRIEF-FOCUSED TREATMENT AND SERVICE SYSTEMS FOR LGBTQIA+ YOUTH THROUGH ADDITIONAL TRAINING OPPORTUNITIES THAT FOCUS ON TREATING LGBTQIA+ POPULATIONS. 2.1 BY SEPTEMBER 29, 2025, SINAI’S BH DEPARTMENT WILL HAVE TRAINED 90% OF PSYCHOTHERAPISTS ON EVIDENCE-BASED PRACTICES FOR TREATING LGBTQIA+ POPULATIONS. NUMBER OF UNDUPLICATED INDIVIDUALS TO BE SERVED WITH AWARD FUNDS YEAR 1 YEAR 2 YEAR 3 YEAR 4 YEAR 5 TOTAL 80 100 120 120 120 540

LEGACY: A COHORT OF YOUTH IN FAMILIES FROM THE BREAST CANCER FAMILY REGISTRY

CHROMATIN PLASTICITY, TRANSCRIPTIONAL ACTIVITY AND KINETICS IN DEVELOPING AND ADULT HUMAN ASTROCYTE AND OLIGODENDROGLIAL LINEAGES

(PQ5) ROLE OF MITOCHONDRIAL DIVISION IN CANCER BIOLOGY

MOLECULAR AND METABOLIC PHENOTYPE OF IMPAIRED ADIPOR1 IN THE HEART

THE ROLE OF MEDIAL AMYGDALA CIRCUITS IN MEDIATING THE EFFECTS OF DIET ON POST-TRAUMATIC BEHAVIORAL AND METABOLIC COMPLICATIONS

CONTROL OF NEURON ACTIVITY AND ANIMAL BEHAVIOR BY NON-CODING RNAS

NEUROPHYSIOLOGICAL MECHANISMS OF VARIABLE ALCOHOL DRINKING BEHAVIORS

THE ROLE OF MEDIAL AMYGDALA CIRCUITS IN MEDIATING THE EFFECTS OF DIET ON POST-TRAUMATIC BEHAVIORAL AND METABOLIC COMPLICATIONS

CHREBP ISOFORMS IN PANCREATIC BETA CELLS

DEXTRAN SULFATE, BETA CELL PRESERVATION AND IMMUNE REGULATION IN TYPE 1 DIABETES

DEVELOPING NEURONAL KCNQ CHANNEL MODULATORS FOR MOOD DISORDERS

COMPREHENSIVE HEALTH INFORMATICS ENGAGEMENT FRAMEWORK FOR PULMONARY REHAB

CHEMICAL INTERVENTION OF INFLUENZA VIRUS RNA NUCLEAR EXPORT

MODELING THE CONTRIBUTION OF COMMON VARIANTS TO SCHIZOPHRENIA RISK

DISSECTION OF SUPPRESSIVE AXES UNDERLYING NATURAL KILLER CELL DYSFUNCTION IN HUMAN BLADDER CANCER

NEURAL CIRCUITRY OF SWEET TASTE

RYAN WHITE TITLE IV WOMEN, INFANTS, CHILDREN, YOUTH AND AFFECTED FAMILY MEMBERS AIDS HEALTHCARE

PODOCYTE TO PODOCYTE PROPAGATION OF HYPERTROPHIC SIGNALS

ROLE OF APOPTOSIS IN THE INTESTINAL EPITHELIUM DURING HOMEOSTASIS AND DISEASE

DETERMINING THE CONTRIBUTION OF LINEAGE INTERMEDIATE TUMOR CELLS DURING PROGRESSION TO T-SCNC

LINKING THE EFFECTS OF 9/11 TO KIDNEY DISEASE

A RANDOMIZED CONTROLLED TRIAL OF INTERNET CBT FOR PTSD IN WTC RESPONDERS

NANOBODIES AS MARKERS AND TOOLS FOR STUDIES OF XENOPUS EMBRYONIC DEVELOPMENT

EXPLORING MECHANISMS OF OBSTRUCTIVE SLEEP APNEA (OSA) IN WTC RESPONDERS

TOWARD SAFER OPIOID PRESCRIBING FOR CHRONIC PAIN IN HIGH RISK POPULATIONS: IMPLEMENTING THE CENTERS FOR DISEASE CONTROL GUIDELINE (CDC) GUIDELINE IN THE PRIMARY CARE HIV CLINIC

SINAI DIABETES CENTER - PROJECT SUMMARY SINAI CHICAGO (SINAI) IS ILLINOIS’ LARGEST PRIVATE SAFETY-NET HEALTHCARE SYSTEM, SERVING PREDOMINANTLY LOW-INCOME COMMUNITIES OF COLOR WITH LARGE MEDICAID-ELIGIBLE POPULATIONS IN CHICAGO. IN RESPONSE TO HIGH DIABETES RATES AND COMMUNITY CALLS FOR COORDINATED, MULTIDISCIPLINARY DIABETES CARE, SINAI DESIGNED THE CENTER FOR DIABETES AND ENDOCRINOLOGY (THE CENTER) WHICH LAUNCHED IN 2020. THE CENTER USES A COMPREHENSIVE MODEL WITH STREAMLINED SERVICES TO ADDRESS THE FULL SPECTRUM OF PATIENT MEDICAL AND NON-MEDICAL NEEDS. WE PROPOSE A CONVERGENT MIXED-METHODS OPTIMIZATION STUDY TO DETERMINE THE APPROPRIATENESS AND FIDELITY OF THREE INTERVENTION COMPONENTS OF A TEAM- BASED CARE MODEL FOR PATIENTS SERVED BY THE CENTER TO DEFINE THE IDEAL SEQUENCE FOR IMPROVING PATIENT OUTCOMES. GROUNDED IN QUALITATIVE METHODOLOGY AND GUIDED BY A SEQUENTIAL MULTIPLE ASSIGNMENT RANDOMIZED TRIAL (SMART), WE PROPOSE EVALUATING THE APPROPRIATENESS OF NOVEL INTERVENTION ENHANCEMENTS (AIM 1); MEASURING FIDELITY OF NEW INTERVENTION ENHANCEMENTS (AIM 2); COMPARING THE EFFECTIVENESS AND DETERMINING OPTIMIZATION OF INTERVENTION ENHANCEMENTS (AIM 3). WE WILL EVALUATE AIM 1 VIA KEY STAKEHOLDER INTERVIEWS AND FOCUS GROUPS. WE WILL ANALYZE AIMS 2 AND 3 BY CONDUCTING DESCRIPTIVE STATISTICS ON ALL VARIABLES, GIVING SPECIAL ATTENTION TO OUTLIER VALUES. WE WILL ALSO RUN BIVARIATE AND MULTIVARIATE ANALYSES ACROSS VARIABLES OF INTEREST AND TIME POINTS TO DETERMINE THE OPTIMAL SEQUENCE OF INTERVENTION ACTIVITIES. WE WILL DISSEMINATE OUR LEARNINGS BROADLY TO KEY STAKEHOLDERS THROUGH COMMUNITY FORUMS, PEER-REVIEWED PUBLICATIONS AND PRESENTATIONS. OUR MULTI-DISCIPLINARY TEAM HAS A WEALTH OF EXPERIENCE IN HEALTH SERVICES PROGRAMMING AS WELL AS RESEARCH AND EVALUATION. WE PROPOSE A 3 YEAR, $1.5 MILLION PROJECT FROM MARCH 2023 TO FEBRUARY 2026.

OPTIMIZING LUNG CANCER SCREENING IN WORLD TRADE CENTER RESCUE AND RECOVERY WORKERS

LINEAGE MARKING IN HUMANIZED MICE TO REVEAL HIV-1 RESERVOIRS

THYROID CANCER RISK IN WTC RESPONDERS

MITRAL REGURGITATION, HEART FAILURE AND CORONARY DISEASE: BENEFITS TO MV REPAIR

MORTALITY AMONG WTC RESCUE AND RECOVERY WORKERS

TRAINING PROVIDERS IN CBT PLUS HYPNOSIS - AN EVIDENCE-BASED FATIGUE INTERVENTION

DISCOVER SMALL MOLECULE CHEMICAL PROBES TO MODULATE RING-TYPE E3 UBIQUITIN LIGASES

2/3 HIGH-RESOLUTION MAPPING OF CELL TYPE-SPECIFIC DNA (HYDROXY)METHYLATION IN THE HUMAN BRAIN DURING POSTNATAL DEVELOPMENT AND IN PSYCHIATRIC DISEASE

DISCOVERY OF SELECTIVE INHIBITORS FOR HISTONE METHYLTRANSFERASES

RABEX-5 REGULATION OF RAS AND NOTCH SIGNALING IN DEVELOPMENT AND DISEASE

CHICAGO WESTSIDE PARTNERSHIP FOR CHILDREN'S ASTHMA INITIATIVE (CWPC-AI)

BEHAVIORAL HEALTH FOR YOUTH & YOUNG ADULTS AT HOLY CROSS HOSPITAL - IN OUR PROPOSAL FOR CONGRESSIONAL DISCRETIONARY SPENDING, BEHAVIORAL HEALTH FOR YOUTH & YOUNG ADULTS AT HOLY CROSS HOSPITAL, SINAI HEALTH SYSTEM’S HOLY CROSS HOSPITAL WILL ADD BEHAVIORAL HEALTH SERVICES FOR 75 OR MORE YOUTH AND YOUNG ADULTS AGES 6-24 AT RISK OR SCREENING POSITIVELY FOR SERIOUS MENTAL HEALTH CONDITIONS. THEY WILL RECEIVE APPROXIMATELY 3,600 VISITS DURING THE YEAR. THE PROGRAM (TO BE NAMED UNDER THE RAINBOW) WILL PROVIDE ASSESSMENT, CASE MANAGEMENT, COUNSELING, ADVOCACY, TRANSPORTATION, AND REFERRALS. SINAI’S HOLY CROSS HOSPITAL SERVES 14 COMMUNITY AREAS ACROSS 7 ZIP CODES IN SOUTHWEST CHICAGO WITH A HARDSHIP INDEX SCORE OF 86 (OUT OF 100); THE RESIDENTS FACE SEVERE HARDSHIPS IN TERMS OF EMPLOYMENT, HOUSING, EDUCATION, AND POVERTY; FACTORS THAT HIGHLY CORRELATE WITH POOR MENTAL AND PHYSICAL HEALTH. IN SINAI CHICAGO’S 2022 COMMUNITY HEALTH NEEDS ASSESSMENT (CHNA) PROCESS, AS WELL AS IN 2016 AND 2019, WE HEARD FROM SOUTHWEST CHICAGO COMMUNITY MEMBERS THAT BEHAVIORAL HEALTH AND COLLECTIVE TRAUMA WITHIN OUR COMMUNITIES – CAUSED BY REPEATED EXPOSURE TO VIOLENCE, RACISM, AND SOCIOECONOMIC THREATS TO WELLBEING – ARE KEY AREAS IN NEED OF IMMEDIATE ATTENTION. HCH’S PROGRAM ( TO BE NAMED UNDER THE RAINBOW LIKE ITS COUNTERPART AT MOUNT SINAI)WILL PROVIDE HIGH-QUALITY, TRAUMA-INFORMED, EFFECTIVE, AND TIMELY ASSESSMENT AND TREATMENT SERVICES TO YOUTH THROUGH YOUNG ADULTS WHO HAVE EXPERIENCED ABUSE, NEGLECT, OR COMPLEX TRAUMA, AND WILL ALSO PROVIDE TREATMENT FOR A WIDE RANGE OF ISSUES INCLUDING DEPRESSION, ANXIETY, ADHD, PSYCHOTIC DISORDERS, GRIEF/LOSS, SCHOOL RELATED PROBLEMS, AND FAMILY CONFLICT. THE PROGRAM HAS TWO GOALS: 1) COMPLETE ALL PREPARATION TO BEGIN YOUTH, ADOLESCENT AD YOUNG ADULT SERVICES IN HOLY CROSS OFFICES BY DECEMBER 2024 AND 2) IMPLEMENTATION OF THE YOUTH, ADOLESCENT AND YOUNG ADULT SERVICES PROGRAM AT HOLY CROSS FOR THE REMAINDER OF THE AWARD PERIOD. HCH UTR (UNDER INTERIM PD, KATHERINE HALL) WILL RECRUIT AND HIRE A 1.0 FTE PROJECT DIRECTOR/CLINICAL SUPERVISOR TO MANAGE THE EMERGING CASELOAD AND ASSIST WITH THE RECRUITMENT AND ON-THE-JOB TRAINING OF THE PSYCHOTHERAPISTS AND OTHER STAFF TO PROVIDE SERVICES WITHIN 60 DAYS OF THE START DATE. HCH WILL HIRE THREE FULL-TIME PSYCHOTHERAPISTS, ALLOCATE A 50% FTE PSYCHIATRIST, AND ALLOCATE OR RECRUIT A 50% FTE CASE MANAGER, A 1 FTE CENTRAL SCHEDULER AND SUPPORT SPECIALIST, AND 65% FTE INSURANCE VERIFIER TO IMPLEMENT THE PROGRAM. ADDITIONALLY, THE PROGRAM WILL ENGAGE COMMUNITY- AND FAITH-BASED ORGANIZATIONS, OTHER CHILD/ADULT-SERVING PROVIDERS, AND RELEVANT PUBLIC AGENCIES IN SOUTHWEST CHICAGO TO MAXIMIZE AND COORDINATE TREATMENT SERVICES AND SUPPORTS AS INDICATED THROUGH SOCIAL DETERMINANTS OF HEALTH SCREENING TO MAXIMIZE THE IMPACT OF THESE SERVICES IN PATIENTS' LIVES.

SEE NOTICE OF AWARD, ATTACHMENT 1 - TERMS AND CONDITIONS, ATTACHMENT D - STATEMENT OF WORK, ABSTRACT.

TRAINING IN EVIDENCE-BASED INTERVENTIONS FOR CANCER-RELATED DISTRESS

INTERCELLULAR SIGNALING AND BIOMECHANICS OF PODOCYTES AND ENDOTHELIAL CELLS IN FSGS

INTERCELLULAR SIGNALING AND BIOMECHANICS OF PODOCYTES AND ENDOTHELIAL CELLS IN FSGS

AN INTEGRATED SYSTEMS BIOLOGY APPROACH FOR OVARIAN CANCER BIOMARKER DISCOVERY

NOVEL TARGETED THERAPIES FOR INFLAMMATORY BREAST CANCER

MULTINATIONAL COLLABORATIVE EVALUATION OF CORNEAL CONFOCAL MICROSCOPY AS A SURROGATE ENDPOINT FOR THE IDENTIFICATION AND PREDICTION OF DIABETIC NEURO

HIV AND HEPATIC INFLAMMATION AND FIBROSIS

RACIAL, CULTURAL, AND DYADIC RELATIONSHIP FACTORS INFLUENCING TREATMENT DECISIONS ABOUT ACTIVE SURVEILLANCE FOR LOCALIZED PROSTATE CANCER

REGENERATIVE MEDICINE AND RESTORATION OF JOINT FUNCTION

ANTIBODY RESPONSES IN HUMANS AFTER INFECTION WITH AVIAN INFLUENZA VIRUSES

COLLABORATIVE RESEARCH: NCS-FR: UNDERSTANDING THE NEUROPEPTIDE MODULATION OF BRAIN CIRCUITS BY ADVANCED NANOMATERIALS AND IMAGING

NORTH LAWNDALE DIABETES COMMUNITY ACTION PROJECT

SPECIAL PROJECTS OF NATIONAL SIGNIFICANCE - DEMONSTRATION/IMPLEMENTATION SITES

UNDERSTANDING THE INTERACTION BETWEEN HOST GENETICS, IMMUNE RESPONSE, AND GUT MICROBES IN POST-OPERATIVE RECURRENCE OF CROHN'S DISEASE - PROJECT SUMMARY/ABSTRACT INTESTINAL RESECTION REMAINS A COMMON COMPLICATION IN CROHN'S DISEASE (CD) DESPITE THE ADVENT OF ADVANCED BIOLOGICS AND SMALL MOLECULE THERAPIES. WITHIN ONE YEAR AFTER ILEOCOLIC RESECTION, OVER 70% OF PATIENTS WITH CD ARE KNOWN TO HAVE ENDOSCOPIC RECURRENCE. EVEN IN PATIENTS TREATED WITH A BIOLOGIC TREATMENT, 30% DEVELOPS RECURRENCE OF CD. DESPITE SIGNIFICANT PROGRESS IN THE MANAGEMENT OF POST-OPERATIVE CD PATIENTS, THERE IS STILL AN UNMET NEED IN EFFICIENTLY TREATING AND PREVENTING RECURRENCE OF CD FOLLOWING ILEAL RESECTION. SINCE 2011, SIX PARTICIPATING GENETIC RESEARCH CENTRES AS PART OF THE NIDDK INFLAMMATORY BOWEL DISEASE GENETIC CONSORTIUM (IBDGC) HAVE RECRUITED PATIENTS FOR THE CD ILEAL POST-OPERATIVE STUDY. THE CONSORTIUM- WIDE EFFORT HAS LED TO A CREATION OF A LARGE BIOBANK OF BLOOD, STOOL, AND BIOPSY SAMPLES DURING THE PERI-OPERATIVE PERIOD AND AT EACH FOLLOW-UP POST-OPERATIVE ENDOSCOPIC PROCEDURES. ALTHOUGH THESE EFFORTS LED TO IMPORTANT BIOMARKER DISCOVERIES RELATED TO POST-OPERATIVE DISEASE RECURRENCE, THE MECHANISM OF INTESTINAL INFLAMMATION INITIATION AFTER ILEAL RESECTION IS STILL UNKNOWN. FOR THIS ANCILLARY STUDY PROPOSAL, WE AIM TO BETTER UNDERSTAND THE PATHOPHYSIOLOGY OF CD BY LEVERAGING THE NIDDK IBDGC POST-OPERATIVE CD COHORT. WE PROPOSE TO MAKE USE OF THE LATEST HIGH-THROUGHPUT OMICS APPROACHES TO THIS COHORT. FIRST, AN UNTARGETED IN-DEPTH ANTIBODY REPERTOIRE PROFILING APPROACH USING PHASE DISPLAY TECHNOLOGY (PHIP-SEQ) WILL HELP US IDENTIFY NOVEL ANTI-MICROBIAL ANTIBODIES ASSOCIATED WITH DISEASE RECURRENCE. SECOND, METAGENOME-ASSEMBLED GENOME ANALYSIS (MAG) ON STOOL AND BIOPSY SAMPLES WILL HELP IDENTIFY NOVEL GUT MICROBIAL FUNCTIONAL GENOMIC SIGNATURES ASSOCIATED WITH POST-OPERATIVE CD RECURRENCE. THIRD, METABOLOMICS ANALYSIS WILL HELP IDENTIFY THE DOWNSTREAM EXPRESSION OF VARIOUS CHANGES THAT OCCUR IN THE GENOME, PROTEOME, AND TRANSCRIPTOME, THAT WILL ULTIMATELY CLOSELY REPRESENT THE PHENOTYPIC FINGERPRINTS OF CD RECURRENCE. ADDITIONALLY, THE ASSOCIATIONS BETWEEN ANTI-MICROBIAL ANTIBODIES, MICROBIOME, AND METABOLOME WITH POST-OPERATIVE CD RECURRENCE CAN BE ASSESSED FOR THEIR DEPENDENCE ON SPECIFIC KNOWN ILEAL CD-ASSOCIATED GENETIC VARIANTS (E.G., LOCATED NOD2, ATG16L1, HLA-DRB1*07:01, LRRK2, MUC19) OR COMBINED CD-GENETIC RISK VARIANTS (E.G., CD-POLYGENIC RISK SCORE). TAKEN TOGETHER, THROUGH THE RESEARCH PROPOSED, WE ANTICIPATE THAT SIGNIFICANT ADVANCES WILL BE MADE TOWARD A BETTER UNDERSTANDING OF THE MECHANISMS OF INTESTINAL INFLAMMATION FOLLOWING ILEAL RESECTION OF CD AND THE TRANSLATION OF THESE DATA INTO CLINICALLY MEANINGFUL TOOLS THAT WILL LEAD TO A LOWER RECURRENCE OF CD.

THE MOUNT SINAI ADOLESCENT HEALTH CENTER (MSAHC) WILL CREATE AN AUTONOMOUS PROGRAM FOR YOUTH VICTIMS OF HUMAN TRAFFICKING, PROMOTING RACIAL EQUITY AND THE REMOVAL OF BARRIERS TO ACCESS AND OPPORTUNITY, SERVING UNDERSERVED YOUTH SURVIVORS OF HUMAN TRAFFICKING TO ADDRESS IDENTIFIED BARRIERS AND GAPS IN MEDICAL, MENTAL HEALTH, HOUSING, CAREER DEVELOPMENT, AND LEGAL SERVICES. MSAHC WILL PROVIDE COMPREHENSIVE HEALTH CARE SERVICES INCLUDING PRIMARY, MENTAL / BEHAVIORAL, SEXUAL AND REPRODUCTIVE, AND OPTICAL CARE TO 100 SURVIVORS OF HUMAN TRAFFICKING EACH YEAR OF THE GRANT. ADDITIONALLY, MSAHC WILL UTILIZE ITS ESTABLISHED CONNECTIONS WITH COVENANT HOUSE NY, STRIVE, AND SANCTUARY FOR FAMILIES TO PROVIDE SURVIVORS WITH STABLE HOUSING, CAREER DEVELOPMENT, AND COMPREHENSIVE LEGAL SERVICES, RESPECTIVELY. ALL SERVICES ARE TO BE PROVIDED FREE OF CHARGE AND CREATED WITHIN THE FRAMEWORKS OF RACIAL, SOCIAL, ECONOMIC, AND SEXUAL AND REPRODUCTIVE JUSTICE TO HELP ACHIEVE HEALTH EQUITY AND AUTONOMY. THE BENEFICIARIES OF THIS PROPOSAL WILL HAVE ACCESSIBLE, HIGH QUALITY, INTEGRATED SERVICES, ENABLING THEM TO HEAL, BUILD RESILIENCY, AND REACH THEIR FULL POTENTIAL. THIS PROGRAM USES AN APPROACH TO CARE EMPOWERING SURVIVORS TO UNDERSTAND THEIR OWN HEALTH CARE DECISIONS AND SUPPORTIVE SERVICE OPTIONS, IN SO DOING BECOMING ADVOCATES FOR NOT ONLY THEMSELVES, BUT FOR OTHERS WITHIN THEIR COMMUNITIES.

DENTAL REIMBURSEMENT PROGRAM

RISK CLUSTERING AND STRATIFICATION IN GENETICALLY HIGH-RISK INDIVIDUALS USING ELECTRONIC MEDICAL RECORDS AND BIOMARKERS

LOCAL COMMUNITY-BASED WORKFORCE TO INCREASE COVID-19 VACCINE ACCESS

ANALYSIS OF TET2 FUNCTION IN ACUTE LEUKEMIA

COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - CONSTRUCTION - SINAI HEALTH SYSTEM ON BEHALF OF HOLY CROSS HOSPITAL BRANDON KING, VICE PRESIDENT OF FACILITIES (773) 257-2400 BRANDON.KING@ SINAI.ORG WWW.SINAICHICAGO.ORG CDS FUNDING TOTALS $900,000 AND WILL SUPPORT RENOVATION OF THE HOLY CROSS HOSPITAL FOURTH FLOOR MEDICAL/BEHAVIORAL HEALTH UNIT. FUNDS ARE ALLOCATED FOR: SITE WORK: $86,541 CONSTRUCTION: $570,029 EQUIPMENT: $92,116 MISCELLANEOUS: $5,000 CONTINGENCIES: $146,314

REGULATION OF HIPPOCAMPAL PLASTICITY AND LEARNING AND MEMORY BY A BLOODBORNE REJUVENATION FACTOR

ROUTES TO ENHANCED HIV NEUROPATHOGENESIS THROUGH EXPRESSION OF SUBCLINICAL LEVELS OF ENDOGENOUS AMYLOID-BETA

DENTAL REIMBURSEMENT PROGRAM

INTERNET-BASED MOTIVATIONAL INTERVIEWING FOR COLONOSCOPY IN AFRICAN AMERICANS

EVALUATING THE EFFECTIVENESS OF LUNG CANCER SCREENING IN PATIENTS WITH COPD

CHARACTERIZATION OF PROTECTIVE ROLES OF APOE2 AGAINST AGING AND ALZHEIMER'S DISEASE

OPTIMIZING POSTOPERATIVE COGNITION IN THE ELDERLY

CLINICAL AND TRANSLATIONAL SCIENCE AWARD

ENHANCING GLUTAMATE TRANSPORT IN AGE-RELATED COGNITIVE DECLINE AND ALZHEIMER'S DISEASE

DEFINING HOST-MICROBIAL INTERACTIONS USING FUNCTIONAL METAGENOMICS

THE ROLE OF ALTERNATIVE SPLICING IN NEURODEGENERATION

THROUGH THIS AWARD, MOUNT SINAI ADOLESCENT HEALTH CENTER (MSAHC) WILL IMPLEMENT THE EXPANDING BEHAVIORAL HEALTH SERVICES FOR HUMAN TRAFFICKING VICTIMS AT THE MOUNT SINAI ADOLESCENT HEALTH CENTER PROGRAM. THE PURPOSE IS TO INCREASE THE QUALITY AND QUANTITY OF BEHAVIORAL HEALTH SERVICES TO ASSIST VICTIMS OF HUMAN TRAFFICKING AGES 10-26 BY ADDING COGNITIVE PROCESSING THERAPY (CPT) TO ITS PROGRAM FOR ADOLESCENT AND YOUNG ADULT HUMAN TRAFFICKING VICTIMS. PROJECT ACTIVITIES INCLUDE TRAINING MSAHC MENTAL HEALTH CLINICIANS IN CPT, IMPLEMENTING CPT SERVICES IN ITS ARTICLE 28 PRIMARY CARE MENTAL HEALTH PROGRAM AND ARTICLE 31 MENTAL HEALTH CLINIC, AND ESTABLISHING A WORKING GROUP AT THE MSAHC TO IMPROVE THE QUALITY OF TRAFFICKING SERVICES. EXPECTED OUTCOMES INCLUDE THE PROVISION OF CPT TO SEX AND LABOR TRAFFICKING VICTIMS; CONNECTION TO COMPREHENSIVE, INTEGRATED EMOTIONAL SUPPORT, SAFETY, AND HEALTH SERVICES; AND REGULAR PROGRAM ASSESSMENTS. THE PROGRAM WILL BE IMPLEMENTED AT THE MSAHC IN EAST HARLEM IN NEW YORK CITY, A COMPREHENSIVE, INTEGRATED, CONFIDENTIAL, YOUTH-SPECIFIC HEALTH CARE PROGRAM WHICH PROVIDES PRIMARY CARE, SEXUAL AND REPRODUCTIVE HEALTH, BEHAVIORAL AND MENTAL HEALTH, HEALTH EDUCATION, NUTRITION, OPTICAL, AND LEGAL SERVICES AT NO COST TO PATIENTS.

INTEGRATIVE APPROACH TO STUDY MITOCHONDRIAL AMINOACYL-TRNA SYNTHETASE DISORDERS

EARLY STAGE IDENTIFICATION AND ENGAGEMENT TO REDUCE DURATION OF UNTREATED PSYCHOSIS (EASIE)

UNRAVELING THE EVOLUTION OF MELANOMA WITHIN THE HOST IMMUNE ECOSYSTEM

MECHANISMS OF COMPLEMENT-MEDIATED PODOCYTE INJURY IN FSGS

HEALTHY HOMES TECH STUDIES

SES AND ALLOSTATIC LOAD: PREGNANCY OUTCOMES AND MATERNAL NEUROBEHAVIOR

NEUROBEHAVIORAL STUDY OF WARNINGS FOR ADOLESCENTS AT RISK FOR NICOTINE DEPENDENCE