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STANDING ANNOUNCEMENT FOR RESIDENTIAL (SHELTER AND/OR TRANSITIONAL FOSTER CARE) SERVICES FOR UNACCOMPANIED CHILDREN-UNLICENSED - ENDEAVORS EAGLE LAKE

HEAD START FULL YEAR/PART DAY

HEAD START AND EARLY HEAD START

THE SSVF PROGRAM'S PURPOSE IS TO PROVIDE SUPPORTIVE SERVICES GRANTS TO PRIVATE NON-PROFIT ORGANIZATIONS AND CONSUMER COOPERATIVES, WHO WILL COORDINATE OR PROVIDE SUPPORTIVE SERVICES TO VERY LOW-INCOME VETERAN FAMILIES WHO ARE RESIDING IN PERMANENT HOUSING, ARE HOMELESS AND SCHEDULED TO BECOME RESIDENTS OF PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD; OR AFTER EXITING PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD, ARE SEEKING OTHER HOUSING THAT IS RESPONSIVE TO SUCH VERY LOW-INCOME VETERAN FAMILY'S NEEDS AND PREFERENCES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES.

HEAD START YEAR 1 NON-COMPETITIVE

THE SSVF PROGRAM'S PURPOSE IS TO PROVIDE SUPPORTIVE SERVICES GRANTS TO PRIVATE NON-PROFIT ORGANIZATIONS AND CONSUMER COOPERATIVES, WHO WILL COORDINATE OR PROVIDE SUPPORTIVE SERVICES TO VERY LOW-INCOME VETERAN FAMILIES WHO ARE RESIDING IN PERMANENT HOUSING, ARE HOMELESS AND SCHEDULED TO BECOME RESIDENTS OF PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD; OR AFTER EXITING PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD, ARE SEEKING OTHER HOUSING THAT IS RESPONSIVE TO SUCH VERY LOW-INCOME VETERAN FAMILY'S NEEDS AND PREFERENCES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES.

THE SSVF PROGRAM'S PURPOSE IS TO PROVIDE SUPPORTIVE SERVICES GRANTS TO PRIVATE NON-PROFIT ORGANIZATIONS AND CONSUMER COOPERATIVES, WHO WILL COORDINATE OR PROVIDE SUPPORTIVE SERVICES TO VERY LOW-INCOME VETERAN FAMILIES WHO ARE RESIDING IN PERMANENT HOUSING, ARE HOMELESS AND SCHEDULED TO BECOME RESIDENTS OF PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD; OR AFTER EXITING PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD, ARE SEEKING OTHER HOUSING THAT IS RESPONSIVE TO SUCH VERY LOW-INCOME VETERAN FAMILY'S NEEDS AND PREFERENCES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES.

NATIONAL OUTREACH PROGRAMS TO PROVIDE PEER SUPPORT COUNSELING SERVICES AND RESOURCES TO SURVIVORS OF FALLEN LAW ENFORCEMENT OFFICERS

THE SSVF PROGRAM'S PURPOSE IS TO PROVIDE SUPPORTIVE SERVICES GRANTS TO PRIVATE NON-PROFIT ORGANIZATIONS AND CONSUMER COOPERATIVES, WHO WILL COORDINATE OR PROVIDE SUPPORTIVE SERVICES TO VERY LOW-INCOME VETERAN FAMILIES WHO ARE RESIDING IN PERMANENT HOUSING, ARE HOMELESS AND SCHEDULED TO BECOME RESIDENTS OF PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD; OR AFTER EXITING PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD, ARE SEEKING OTHER HOUSING THAT IS RESPONSIVE TO SUCH VERY LOW-INCOME VETERAN FAMILY'S NEEDS AND PREFERENCES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES.

CARES 2.0 FUNDING FOR COVID19. THE SSVF PROGRAM'S PURPOSE IS TO PROVIDE SUPPORTIVE SERVICES GRANTS TO PRIVATE NON-PROFIT ORGANIZATIONS AND CONSUMER COOPERATIVES, WHO WILL COORDINATE OR PROVIDE SUPPORTIVE SERVICES TO VERY LOW-INCOME VETERAN FAMILIES WHO ARE RESIDING IN PERMANENT HOUSING, ARE HOMELESS AND SCHEDULED TO BECOME RESIDENTS OF PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD; OR AFTER EXITING PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD, ARE SEEKING OTHER HOUSING THAT IS RESPONSIVE TO SUCH VERY LOW-INCOME VETERAN FAMILY'S NEEDS AND PREFERENCES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES.

CARES FUNDING FOR COVID19. THE SSVF PROGRAM'S PURPOSE IS TO PROVIDE SUPPORTIVE SERVICES GRANTS TO PRIVATE NON-PROFIT ORGANIZATIONS AND CONSUMER COOPERATIVES, WHO WILL COORDINATE OR PROVIDE SUPPORTIVE SERVICES TO VERY LOW-INCOME VETERAN FAMILIES WHO ARE RESIDING IN PERMANENT HOUSING, ARE HOMELESS AND SCHEDULED TO BECOME RESIDENTS OF PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD; OR AFTER EXITING PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD, ARE SEEKING OTHER HOUSING THAT IS RESPONSIVE TO SUCH VERY LOW-INCOME VETERAN FAMILY'S NEEDS AND PREFERENCES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES.

THE SSVF PROGRAM'S PURPOSE IS TO PROVIDE SUPPORTIVE SERVICES GRANTS TO PRIVATE NON-PROFIT ORGANIZATIONS AND CONSUMER COOPERATIVES, WHO WILL COORDINATE OR PROVIDE SUPPORTIVE SERVICES TO VERY LOW-INCOME VETERAN FAMILIES WHO ARE RESIDING IN PERMANENT HOUSING, ARE HOMELESS AND SCHEDULED TO BECOME RESIDENTS OF PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD; OR AFTER EXITING PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD, ARE SEEKING OTHER HOUSING THAT IS RESPONSIVE TO SUCH VERY LOW-INCOME VETERAN FAMILY'S NEEDS AND PREFERENCES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES.

SYSTEMATIC FUNCTIONAL INTERPRETATION OF REGULATORY VARIANTS IN SCHIZOPHRENIA

CONCERNS OF POLICE SURVIVORS (C.O.P.S.), FOUNDED IN 1984, IS A NATIONAL NON-PROFIT ORGANIZATION WITH THE MISSION OF REBUILDING THE SHATTERED LIVES OF SURVIVORS AND CO-WORKERS AFFECTED BY LINE OF DUTY DEATHS. C.O.P.S., AFTER EXPERIENCING A SHARP INCREASE IN LINE OF DUTY DEATHS OVER THE PAST FOUR YEARS, NOW PROVIDES SERVICES TO THE 81,000 SURVIVORS IN C.O.P.S. SECURE DATABASE. C.O.P.S. WILL PARTNER WITH THE PUBLIC SAFETY OFFICERS BENEFIT (PSOB) OFFICE TO CONTINUE TO BUILD THEIR SURVIVOR NETWORK AND PROVIDE SERVICES TO SURVIVORS THROUGH THEIR 14 HANDS-ON PROGRAMS AND THROUGH OUTREACH BY THEIR 54 CHAPTERS. TWO OF THESE PROGRAMS ARE NEW AND DIRECTLY BENEFIT SUICIDE SURVIVORS WHO INTEND TO FILE FOR PSOB BENEFITS. C.O.P.S. WILL ALSO CONTINUE TO HOST THE POLICE SURVIVORS CONFERENCE DURING NATIONAL POLICE WEEK AND CHAIR THE NATIONAL POLICE WEEK COMMITTEE ENSURING POLICE SURVIVORS ARE SUPPORTED AS THEY ATTEND THE NUMEROUS NATIONAL MEMORIAL EVENTS THAT WEEK. EVERY SURVIVOR OF A LINE OF DUTY DEATH IS INVITED TO NATIONAL POLICE WEEK THROUGH C.O.P.S. C.O.P.S. WILL CONDUCT LAW ENFORCEMENT TRAINING, IN PERSON AND VIRTUALLY TO PREPARE AGENCIES TO RESPOND TO A LINE OF DUTY DEATHS OR TRAUMATIC INCIDENTS AND WILL PRESENT AT LAW ENFORCEMENT CONFERENCES TO EDUCATE ABOUT C.O.P.S. SERVICES AND PSOB.C.O.P.S. WILL HOST AN ANNUAL NATIONAL CONFERENCE ON LAW ENFORCEMENT WELLNESS AND TRAUMA TO ENGAGE LAW ENFORCEMENT IN THE IMPORTANCE OF PREPAREDNESS AND TO INCREASE KNOWLEDGE OF THE PSOB BENEFITS. C.O.P.S. OFFERS MONTHLY VIRTUAL MEETINGS FOR NEW SURVIVORS INTRODUCING THEM TO THE PSOB PROGRAM AND OTHER AVAILABLE SERVICES AND VIRTUAL PEER SUPPORT SESSIONS FOR NEW AND SEASONED SURVIVORS. C.O.P.S. NOW OFFERS MUCH OF ITS TRAINING VIRTUALLY IN ORDER SAVE COSTS AND REACH MORE PARTICIPANTS. C.O.P.S. COMMUNICATES WITH LAW ENFORCEMENT AGENCIES AND SURVIVORS OF FALLEN OFFICERS THROUGH THEIR WEBSITE, PRINTED AND EMAIL NEWSLETTERS, INNOVATIVE VIDEOS, PODCASTS, PHONE APPLICATIONS AND SOCIAL MEDIA. C.O.P.S. HAS A SECURE DATABASE OF LAW ENFORCEMENT SURVIVOR CONTACTS AND THE INFORMATION CONCERNING THEIR FALLEN OFFICERS.C.O.P.S. HAS INCREASED THE CAPABILITY OF THE DATABASE TO ALSO CAPTURE SUICIDE SURVIVORS TO ENSURE THEY ARE ALSO OFFERED PSOB ASSISTANCE AND C.O.P.S. SERVICES. C.O.P.S. WILL PARTNER WITH PSOB TO USE THIS INFORMATION TO DETERMINE ELIGIBILITY FOR C.O.P.S. SERVICES AND TO INFORM OF THE PSOB BENEFITS AVAILABLE TO SURVIVORS. C.O.P.S. IS COMMITTED TO COLLECTING DATA FROM ALL OF ITS SERVICES TO FOSTER A CULTURE OF USING EVIDENCE-BASED PRACTICES TO ENSURE CONTINUOUS IMPROVEMENT.

NATIONAL OUTREACH PROGRAMS TO PROVIDE HEALING, LOVE AND LIFE RENEWED TO AMERICA''S LAW ENFORCEMENT SURVIVING FAMILIES AND AFFECTED CO-WORKERS.

NATIONAL OUTREACH PROGRAMS TO PROVIDE PEER SUPPORT COUNSELING SERVICES AND RESOURCES TO SURVIVORS OF FALLEN LAW ENFORCEMENT OFFICERS

THE SSVF PROGRAM’S PURPOSE IS TO PROVIDE SUPPORTIVE SERVICES GRANTS TO PRIVATE NON-PROFIT ORGANIZATIONS AND CONSUMER COOPERATIVES, WHO WILL COORDINATE OR PROVIDE SUPPORTIVE SERVICES TO VERY LOW-INCOME VETERAN FAMILIES WHO ARE RESIDING IN PERMANENT HOUSING, ARE HOMELESS AND SCHEDULED TO BECOME RESIDENTS OF PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD; OR AFTER EXITING PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD, ARE SEEKING OTHER HOUSING THAT IS RESPONSIVE TO SUCH VERY LOW-INCOME VETERAN FAMILY’S NEEDS AND PREFERENCES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES.

THE SSVF PROGRAM'S PURPOSE IS TO PROVIDE SUPPORTIVE SERVICES GRANTS TO PRIVATE NON-PROFIT ORGANIZATIONS AND CONSUMER COOPERATIVES, WHO WILL COORDINATE OR PROVIDE SUPPORTIVE SERVICES TO VERY LOW-INCOME VETERAN FAMILIES WHO ARE RESIDING IN PERMANENT HOUSING, ARE HOMELESS AND SCHEDULED TO BECOME RESIDENTS OF PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD; OR AFTER EXITING PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD, ARE SEEKING OTHER HOUSING THAT IS RESPONSIVE TO SUCH VERY LOW-INCOME VETERAN FAMILY'S NEEDS AND PREFERENCES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES.

DECIPHERING THE HORMONAL AND NOCICEPTIVE MECHANISMS UNDERLYING BLADDER PAIN

HOMELESS PREVENTION

HOMELESS PREVENTION

BUILDING CAPACITY OF THE PASTEUR INSTITUTE TO PROVIDE QUALITY LABORATORY DIAGNOSI

CIVIC ADVOCACY AND PARTNERSHIP ACTIVITY (CAPA)

HOMELESS PREVENTION

DEVELOPMENT OF A HANDHELD RAPID AIR SENSING SYSTEM TO MONITOR AND QUANTIFY SARS-COV-2 IN AEROSOLS IN REAL-TIME - PROJECT SUMMARY THE ABILITY TO RAPIDLY MONITOR SARS-COV-2 IN AEROSOL—DROP PARTICLES <5 ΜM IN SIZE THAT EVAPORATE INTO DROPLET NUCLEI AND BECOME SUSPENDED IN AIR—AT THE POINT OF PRESENTATION IS CRITICAL TO MANAGING THE RISK OF INFECTION BY AIRBORNE TRANSMISSION AS PEOPLE RETURN TO THEIR COMMUNITIES, WORKPLACES, AND SCHOOLS DURING THE COVID-19 PANDEMIC. HOWEVER, CURRENT ENZYME-BASED METHODS LACK SENSITIVITY, SPEED, SIMPLICITY, AND REQUIRE LAB EQUIPMENT—HENCE, LACK THE CAPABILITY FOR REAL-TIME POINT-OF-PRESENTATION (POP) MONITORING. IN THE ABSENCE OF A REAL-TIME POP MONITORING CAPABILITY, SARS-COV-2 TRANSMISSION REMAINS POORLY UNDERSTOOD. IN THIS APPLICATION, A MULTIDISCIPLINARY RESEARCH APPROACH THAT INTEGRATES INNOVATIONS IN RAPID-KINETIC CHEMICAL AUTO-LIGATION, NON- ENZYMATIC ISOTHERMAL SIGNAL AMPLIFICATION, SOLID-STATE ELECTRONICS, AND BIOPHOTONICS IS PROPOSED TO ENABLE THE DEVELOPMENT OF A NOVEL AIR MONITORING SYSTEM (AMS) THAT DETECTS AND QUANTIFIES AEROSOLIZED SARS-COV-2 AT THE POINT OF PRESENTATION IN REAL-TIME. RECENT ADVANCES IN VIRAL CULTURING PROTOCOLS, AIR SAMPLING TECHNOLOGY, AND SINGLE-PHOTON DETECTION CAPABILITY WILL PROVIDE THE FRAMEWORK FOR A COLLABORATIVE RESEARCH ENDEAVOR TO ESTABLISH A NEW PARADIGM TO ADDRESS THE KNOWLEDGE GAP BETWEEN THE SPREAD OF COVID-19 AND SARS-COV-2 AEROSOL TRANSMISSION. THEREFORE, THE PROPOSAL IS AIMED AT TRANSFORMING THE WAY COVID-19 IS CURRENTLY RESEARCHED BY PROVIDING A TOOL TO ENABLE UNPARALLELED STUDIES THAT WILL SIGNIFICANTLY ADVANCE THE CURRENT KNOWLEDGEBASE. THESE TRANSFORMATIVE STUDIES COULD ULTIMATELY GUIDE A NEW FIELD OF INVESTIGATIONS THAT LEAD TO A BETTER UNDERSTANDING OF COVID-19 SPREAD, SUCH AS VIRAL EXPOSURE VS. RISK, VIRAL DECAY RATE VS. INFECTIVITY, AND VIRAL LOAD VS. INFECTIOUS DOSE IN SARS-COV-2 AIRBORNE TRANSMISSION. AT A MINIMUM, THE PROPOSED THREE RESEARCH OBJECTIVES WILL PROVIDE A BASIC UNDERSTANDING OF COVID-19 AEROSOL TRANSMISSION. FIRSTLY, CURRENT AIR SAMPLING SYSTEMS USE A MULTI-STEP WORKFLOW THAT TAKES SEVERAL HOURS TO COMPLETE AND REQUIRES LAB EQUIPMENT, REAGENTS, AND SIGNIFICANT HANDS-ON TIME. THE GOAL OF OBJECTIVE 1 IS TO COMBINE AIR SAMPLING AND DETECTION INTO A ONE-STEP REAL-TIME POP AMS DEVICE THAT YIELDS SARS-COV-2 QUANTIFICATION RESULTS IN LESS THAN 5 MINUTES, WITHOUT LAB EQUIPMENT OR REAGENTS. SECONDLY, VIRAL INOCULUM, OR INITIAL DOSE OF VIRUS, ASPIRATED INTO THE NASAL CAVITY AND LUNGS HAS BEEN ASSOCIATED WITH DISEASE ONSET AND SEVERITY. THE GOAL OF OBJECTIVE 2 IS TO OPTIMIZE AND VALIDATE AMS TO CORRELATE READINGS FROM THE AIR MONITORING DEVICE WITH TISSUE-CULTURE INFECTIOUS DOSE (TCID50) AND REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION (RT-PCR) QUANTITIES. THESE PARAMETERS CAN THEN LATER BE APPLIED TO HUMAN STUDIES TO DETERMINE THE HUMAN INFECTIOUS DOSE OF SARS-COV-2 BY AEROSOL TRANSMISSION. THIRDLY, FIELD-BASED TESTING IN HOSPITALS WILL PROVIDE A MEANS TO BETA TEST AMS PERFORMANCE IN HIGH-RISK ENVIRONMENTS. THE GOAL OF OBJECTIVE 3 IS TO CALIBRATE AMS MEASUREMENTS WITH RT-PCR CYCLE-THRESHOLD (CT) VALUES AND CELL-CULTURE TCID50 VIABILITY RESULTS AND THEN BENCHMARK WITH RESULTS FROM HIGH-RISK ENVIRONMENTS TAKEN FROM AROUND THE WORLD TO CORRELATE SARS-COV-2 AEROSOL CONCENTRATIONS WITH GLOBAL INFECTION RATE, AS A POTENTIAL FOR ESTABLISHING THRESHOLD LEVELS.

THE SSVF PROGRAM'S PURPOSE IS TO PROVIDE SUPPORTIVE SERVICES GRANTS TO PRIVATE NON-PROFIT ORGANIZATIONS AND CONSUMER COOPERATIVES, WHO WILL COORDINATE OR PROVIDE SUPPORTIVE SERVICES TO VERY LOW-INCOME VETERAN FAMILIES WHO ARE RESIDING IN PERMANENT HOUSING, ARE HOMELESS AND SCHEDULED TO BECOME RESIDENTS OF PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD; OR AFTER EXITING PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD, ARE SEEKING OTHER HOUSING THAT IS RESPONSIVE TO SUCH VERY LOW-INCOME VETERAN FAMILY'S NEEDS AND PREFERENCES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES.

HOMELESS PREVENTION

HEAD START AND EARLY HEAD START

BUILDING CAPACITY OF THE PASTEUR INSTITUTE TO PROVIDE QUALITY LABORATORY DIAGNOSIS AND SURVEILLANCE IN 6 ALREADY IMPLEMENTED RAGIONAL LABS AND 4 NEW REGIONAL LABS.THE PROJECT ALSO EMPHASES TB

TRI-COUNTY BEHAVIORAL HEALTHCARE CMHC - TRI-COUNTY BEHAVIORAL HEALTHCARE'S (TCBHC) PROPOSED PROJECT WOULD SUPPORT AND RESTORE VITAL CLINICAL SERVICE DELIVERY AND RECOVERY-ORIENTED SUPPORT SERVICES TO INDIVIDUALS WITH SMI, SED, COD IN THE TEXAS COUNTIES OF MONTGOMERY, LIBERTY, AND WALKER. THE THREE MOSTLY RURAL COUNTIES CONTAIN MANY BEHAVIORAL HEALTH AND HEALTH DISPARITY POPULATIONS, INCLUDING ECONOMICALLY DISADVANTAGED COMMUNITIES (POVERTY RATES RANGE FROM 10.3% TO 24.4%; THE NATIONAL AVERAGE IS 10.4%), AND MINORITY POPULATIONS (BLACK/AFRICAN-AMERICAN POPULATIONS RANGE FROM 4.6% TO 23%, HISPANIC/LATINO POPULATIONS RANGE FROM 18% TO 23%, WHITE POPULATIONS RANGE FROM 54% TO 63%, COMPARED TO THE NATIONAL AVERAGE OF 76.3% WHITE), WITH APPROXIMATELY 17% SPANISH-SPEAKING LANGUAGE MINORITIES. THE PANDEMIC HAS SIGNIFICANTLY DECREASED TCBHC'S REVENUE WHILE INCREASING COMMUNITY NEED, JEOPARDIZING THE ABILITY TO PROVIDE KEY SERVICES. TCBHC HAS SEEN UNPRECEDENTED INCREASES IN MENTAL ILLNESS SEVERITY, SYMPTOMS AND CRISES, STEADILY RISING SERVICE REQUESTS AND CRISIS CONTACTS, AND NEW GAPS IN ACCESS TO TIMELY MENTAL HEALTH CARE AND OTHER NEEDED SERVICES. CLIENT EMPLOYMENT IS DOWN BY 20%, AND CLIENTS ARE LOSING ACCESS TO PRIMARY HEALTH CARE, CHRONIC HEALTH CONDITION MANAGEMENT AND OTHER SUPPORTIVE SERVICES THAT IMPROVE MENTAL HEALTH OUTCOMES, AND ENHANCE TREATMENT ENGAGEMENT AND EFFICACY. THE PROPOSED PROJECT WOULD SUPPORT AND RESTORE CORE CLINICAL SERVICES, INCLUDING: 1. SUSTAINING 24/7/365 CRISIS RESPONSE CAPACITY (OBJECTIVES INCLUDE MAINTAINING OUR WALK-IN CRISIS AND MCOT SERVICES, AVOIDING UNNECESSARY PSYCHIATRIC ADMISSIONS FOR INVOLUNTARY INDIVIDUALS BY PROVIDING PSYCHIATRIC EVALUATION, EITHER IN PERSON OR VIA TELEHEALTH; SUICIDE PREVENTION TRAINING; AND COMMUNITY OUTREACH); 2. SUSTAINING OUTPATIENT INTEGRATED HEALTH (IH) AND WELLNESS SERVICES TO PROVIDE PRIMARY CARE, CHRONIC CONDITION MANAGEMENT, AND HEALTH EDUCATION AND PROMOTION TO INDIVIDUALS WHOSE MENTAL HEALTH NEEDS COMPLICATE RECEIVING THESE SERVICES IN MAINSTREAM SETTINGS (OBJECTIVES INCLUDE IMPROVED BLOOD PRESSURE AMONG IH CLIENTS, WELLNESS ACTIVITIES THAT IMPROVE HEALTH BEHAVIOR KNOWLEDGE AND SKILLS); 3. EXPANDING SUPPORTED EMPLOYMENT AND EDUCATION (SEE) SERVICES (OBJECTIVES INCLUDE CLIENTS OBTAINING AND MAINTAINING COMMUNITY BASED EMPLOYMENT AND EDUCATION); 4. ENHANCING OUR ABILITY TO PARTNER WITH SCHOOLS TO SERVE CHILDREN/YOUTH WITH SED BY HIRING A SCHOOL-BASED SERVICE INTENSIVE COORDINATOR (OBJECTIVES INCLUDE RAISING AWARENESS OF AND FACILITATING ACCESS TO MENTAL HEALTH SERVICES); AND 5. SUPPORTING THE MENTAL HEALTH AND WELLBEING OF STAFF BY DEVELOPING RESPONSIVE RESOURCES/TRAINING. WITH OVER 38 YEARS OF EXPERIENCE PROVIDING CULTURALLY COMPETENT, TRAUMA INFORMED, RECOVERY-ORIENTED AND PERSON-CENTERED CARE TO DIVERSE UNDERSERVED POPULATIONS IN OUR SERVICE AREA, TCBHC IS WELL QUALIFIED TO CARRY OUT THE PROPOSED PROJECT. EVALUATION WILL BE CONDUCTED BY SAE AND ASSOCIATES (SAE) BEHAVIORAL HEALTH EVALUATION (BHE), WHICH HAS EVALUATED CCBHC AND CMHC PROJECTS AND MULTIPLE SAMHSA INITIATIVES. 500 INDIVIDUALS WILL BE SERVED IN EACH YEAR OF THE PROJECT, FOR A TOTAL OF 1000 UNDUPLICATED INDIVIDUALS.

HOMELESS PREVENTION

CONTINUUM OF CARE PROGRAM

PSYCHOSOCIAL INTERVENTION, MATERNAL INFLAMMATION, AND BIRTH OUTCOMES: CENTERING VS. ROUTINE PRENATAL CARE (PIINC) STUDY

MODELING ALZHEIMER'S DISEASE GENETIC VARIANTS IN HIPSC

EARLY MENSTRUAL PAIN IMPACT ON MULTISENSORY HYPERSENSITIVITY

A NOVEL DATA SCIENCE AND NETWORK ANALYSIS APPROACH TO QUANTIFYING FACILITATORS AND BARRIERS OF LOW TIDAL VOLUME VENTILATION IN AN INTERNATIONAL CONSORTIUM OF MEDICAL CENTERS

TRI-COUNTY BEHAVIORAL HEALTHCARE EXPANDED CCBHC ACCESS - TRI-COUNTY BEHAVIORAL HEALTH CARE, A SAFETY NET PROVIDER OF BEHAVIORAL HEALTH AND HOUSING TO LOW-INCOME UNDERSERVED POPULATIONS IN 3 COUNTIES AT THE PERIPHERY OF THE HOUSTON, TEXAS METROPOLITAN AREA, WILL ESTABLISH A CCBHC TO PROVIDE EXPANDED ACCESS TO TREATMENT FOR ADULTS WITH SMI AND COD, INCREASED RURAL SUD TREATMENT, EXPANDED MH CARE FOR CHILDREN/YOUTH WITH SED, INCLUDING SCHOOL-BASED SERVICES, AND CARE COORDINATION FOR CHRONIC HEALTH ISSUES. TRI-COUNTY [TCBHC] WILL ADD THE CAPACITY TO PROVIDE SERVICES IN SPANISH FOR THE GROWING POPULATION OF CHILDREN AND ADULTS WITH LIMITED ENGLISH LITERACY. THE PROJECT NAME IS THE TRI-COUNTY BEHAVIORAL HEALTHCARE EXPANDED CCBHC ACCESS. TOTAL AREA POPULATION IS OVER 768,551 PERSONS IN THREE COUNTIES. POVERTY RATES FOR THESE COUNTIES RANGE FROM 10.3% TO 24.4%. WHITE POPULATION RANGES FROM 54% TO 63%, HISPANIC FROM 18% TO 23%, AND AFRICAN AMERICAN FROM 4.6% TO 23%. FIFTY-FIVE PERCENT OF ADULTS SERVED HAVE AT LEAST A GED, 27% ARE EMPLOYED, 3.9% ARE HOMELESS, AND 45% REPORT NO INCOME. THE CCBHC NEEDS ASSESSMENT INDICATED THAT THERE IS A HIGH INCIDENCE OF UNTREATED MENTAL ILLNESS AND SUBSTANCE ABUSE, ATTRIBUTABLE TO DEMAND FAR EXCEEDING RESOURCES, POOR ACCESS TO LIMITED SERVICES, COSTS BEYOND THE MEANS OF LOW-INCOME CLIENTS, AND STIGMA ASSOCIATED WITH SEEKING CARE. FOUR MAJOR PROJECT GOALS ADDRESS THE UNMET NEED IN THE CATCHMENT AREA: 1) INCREASE ACCESS TO SUD TREATMENT FOR RURAL CONSUMERS; 2) INCREASE ACCESS TO MH CARE FOR CHILDREN/YOUTH WITH SED, THROUGH EXPANDED INTAKE, EXPANDED THERAPY AND CULTURALLY AND LINGUISTICALLY APPROPRIATE OUTPATIENT AND SCHOOL-BASED TREATMENT; 3) INCREASE ACCESS TO THERAPY FOR ADULTS WITH SMI AND COD AND CULTURALLY APPROPRIATE OUTPATIENT TREATMENT AND PSYCHOSOCIAL INTERVENTIONS; 4) PROVIDE CARE COORDINATION TO IMPROVE HEALTH OUTCOMES FOR THE POPULATIONS OF FOCUS. OBJECTIVES INCLUDE: ADD IOP SUD GROUPS IN 3 RURAL SITES; INCREASE WALK-IN CLINIC DAYS FOR CHILDREN/YOUTH AND FAMILIES IMPACTED BY SUD; ADD SCHOOL-BASED MH SERVICES IN RURAL SCHOOLS WITH HIGH PROPORTIONS OF SPANISH-SPEAKING CHILDREN/YOUTH; ELIMINATE PAST 30-DAY SUBSTANCE USE FOR 30% OF ADULTS AND YOUTH IN SUD TREATMENT FOR 6 MONTHS; REDUCE SYMPTOMS OF SED FOR 50% OF CHILDREN/YOUTH BY TREATMENT COMPLETION; REDUCE DEPRESSIVE SYMPTOMS OF 50% OF ADULTS WITH SMI/COD AFTER TREATMENT COMPLETION. IN ADDITION TO ADDING MH AND SUD TREATMENT STAFF, SOME BILINGUAL IN SPANISH AND ENGLISH, THE PROJECT WILL ADD A CARE COORDINATION TEAM CONSISTING OF A LICENSED VOCATIONAL NURSE, MH CLINICIAN, CERTIFIED PEER RECOVERY SPECIALIST, A BENEFITS SPECIALIST, AND A DATA ANALYST. THE EVALUATION WILL BE CONDUCTED BY SAE AND ASSOCIATES (SAE) BEHAVIORAL HEALTH EVALUATION (BHE), WHICH HAS EVALUATED CCBHC PROJECTS AND MULTIPLE SAMHSA INITIATIVES. 150 ADULTS AND 167 CHILDREN/YOUTH WILL BE SERVED IN YEAR 1, 205 ADULTS AND 235 CHILDREN/YOUTH IN YEAR 2, WITH A TOTAL OF 757 UNDUPLICATED CLIENTS SERVED OVER THE 2 PROJECT YEARS.

< STRENGTHEN PUBLIC HEALTH LABORATORY SYSTEMS FOR PRIORITIZE DISEASES, ANTIMICROBIAL RESISTANCE AND OUTBREAKS DETECTION AND SURVEILLANCE IN COTE D?IVOIRE?

TARGETING INTERINDIVIDUAL VARIABILITY IN NSAID RESPONSES TO MITIGATE CHRONIC PELVIC PAIN RISK IN DYSMENORRHEA - MENSTRUAL PAIN (DYSMENORRHEA) IS A MAJOR CAUSE OF DISTRESS, DISABILITY, AND DEVELOPMENT OF CHRONIC PELVIC PAIN (CPP). VERY LITTLE IS KNOWN ABOUT HOW LOCAL UTERINE INFLAMMATION AND CENTRAL NEURAL DYSREGULATION INTERACT TO CAUSE PAINFUL PERIODS. UNDERSTANDING THEIR INTERACTION AND HOW IT MIGHT WORSEN CENTRAL NEURAL HYPERSENSITIVITY IS ESSENTIAL TO PREVENT DYSMENORRHEA FROM PROGRESSING INTO CPP CONDITIONS LIKE BLADDER PAIN SYNDROME, IRRITABLE BOWEL SYNDROME, OR ENDOMETRIOSIS. THERE ARE TWO FACTORS IN DYSMENORRHEA WE HAVE STUDIED THAT HOLD PROMISE AS TARGETS TO REDUCE FUTURE RISK OF CPP – THE PRESENCE OF CO-OCCURRING BLADDER HYPERSENSITIVITY AND THE INDIVIDUAL RESPONSE TO COMMON ANTI-INFLAMMATORY TREATMENTS. THE EXPANSION OF PAIN FROM ONE PELVIC ORGAN TO NEARBY ONES SUGGESTS SENSORY PROCESSING DYSREGULATION IN THE SPINAL CORD OR BRAIN. OUR PRELIMINARY DATA SHOWS THAT EFFECTIVE NSAID THERAPY FOR DYSMENORRHEA MAY REDUCE FUTURE CPP RISK BY NORMALIZING LOCAL NERVE ACTIVATION, INFLAMMATORY MOLECULES IN THE UTERINE LINING, AND PAINFUL HYPERSENSITIVITY IN ADJACENT PELVIC ORGANS. TO DISTINGUISH THE ROLE OF DIFFERENT SENSORY MECHANISMS IN CPP PROGRESSION, OUR INTERDISCIPLINARY TEAM WILL USE A COLLECTION OF VALIDATED SENSORY TASKS INVOLVING MECHANICAL, THERMAL, ELECTRICAL STIMULATION AND BLADDER FILLING. OUR PROPOSAL ALSO PAIRS HIGH-DENSITY ELECTROENCEPHALOGRAPHY WITH SENSORY TESTING TO IDENTIFY BRAIN DIFFERENCES RELATED TO ABNORMAL PAIN INTERPRETATION. WE PLAN TO ADMINISTER THESE TASKS ALONG WITH SYMPTOM QUESTIONNAIRES TO UNDERSTAND WHY SOME WOMEN WITH MENSTRUAL PAIN RESPOND BETTER TO NSAIDS, AND WHICH FACTORS PREDICT DIMINISHED CPP RISK FOLLOWING AN OPTIMIZED PROGRAM TO REDUCE MENSTRUAL PAIN. IN AIM 1 WE WILL CONDUCT A ONE- YEAR, RANDOMIZED CONTROLLED TRIAL (N=300) OF OPTIMIZED NSAID VS. PLACEBO TREATMENT FOR PERIOD PAIN IN MODERATE-PLUS DYSMENORRHEA SUFFERERS. WE WILL DETERMINE WHETHER ACTIVE TREATMENT, MENSTRUAL PAIN RELIEF, AND LOWER LEVELS OF UTERINE INFLAMMATORY MOLECULES PREDICT LOWER NONMENSTRUAL PELVIC PAIN (NMPP, A MARKER FOR FUTURE CPP RISK) AT ONE YEAR POST-TREATMENT. AIM 2, CONDUCTED WITHIN THE AIM 1 STUDY STRUCTURE, WILL ESTABLISH WHICH SPECIFIC SENSORY TESTS PREDICT REDUCTIONS IN NMPP FOLLOWING TREATMENT. EEG WILL BE USED TO PINPOINT PRECISE MECHANISMS FOR DIFFERENCES IN THESE SENSORY RESPONSES. COLLECTIVELY, THIS STUDY OF HIGHER-RISK WOMEN IS DESIGNED TO CHARACTERIZE HOW MENSTRUAL PAIN AND BLADDER HYPERSENSITIVITY INTERACT TO PROMOTE CPP, AND IF THESE FACTORS PREDICT WHO BENEFITS FROM EARLY PREVENTATIVE TREATMENT. THE APPROACH IS NOVEL FOR USING A SAMPLE OF WOMEN ENRICHED FOR FUTURE PAIN RISK (WOMEN WITH DYSMENORRHEA AND BLADDER PAIN) AND FOR CONDUCTING FUTURE PAIN-RISK PREDICTION WITH RECOGNIZED FACTORS: SENSORY TESTING PROFILES, ADJACENT ORGAN PAIN INVOLVEMENT, AND OBSERVED RESPONSE TO A TARGETED TREATMENT. STRUCTURAL EQUATION MODELING WILL BE USED TO FORMALLY DEFINE HOW THESE INTERACT TO CAUSE CPP WHILE CONTROLLING FOR OTHER KEY PAIN RISK FACTORS, SUCH AS RELATIVE LOCAL INFLAMMATION AND PSYCHOSOCIAL PROFILES. THESE STUDY RESULTS OBTAINED BY A DIVERSE TEAM OF INTERDISCIPLINARY COLLABORATORS ARE EXPECTED TO MARKEDLY IMPROVE OUR UNDERSTANDING OF PAIN RISK HETEROGENEITY FOR CHRONIC PAIN PREVENTION

INTEGRATING EPIGENOMICS WITH DNA BREATHING DYNAMICS FOR HUMAN NON-CODING DISEASE VARIANTS

ANESTHESIA-INDUCED LEARNING DEFICIENCY AND BRAIN HYPEROXIA

NORTH CENTRAL BEHAVIORAL HEALTH SYSTEMS SAMHSA CCBHC PDI - NORTH CENTRAL BEHAVIORAL HEALTH SYSTEMS (NCBHS) WILL PROVIDE COMPREHENSIVE, COORDINATED BEHAVIORAL HEALTH CARE TO CHILDREN AND YOUTH WITH SERIOUS EMOTIONAL DISTURBANCE (SED), ADULTS WITH SERIOUS MENTAL ILLNESS (SMI), AND PEOPLE WITH SUBSTANCE USE DISORDERS (SUD) AND/OR CO-OCCURRING DISORDERS (COD) IN THE SERVICE AREA OF LASALLE COUNTY, ILLINOIS. INDIVIDUALS EXPERIENCING A MENTAL HEALTH OR SUBSTANCE USE-RELATED CRISIS, SERVICE MEMBERS, VETERANS, AND MILITARY FAMILIES WILL ALSO RECEIVE CARE. AS A CERTIFIED COMMUNITY BEHAVIORAL HEALTH CLINIC (CCBHC), NCBHS WILL PROVIDE A COMPREHENSIVE RANGE OF SERVICES TO THE POPULATION OF FOCUS, INCLUDING EXPANDING PRIMARY CARE SCREENING; MONITORING OF BEHAVIORAL HEALTH AND PHYSICAL HEALTH CONDITIONS FOR INDIVIDUALS OF ALL AGES; EXPANSION AND ENHANCEMENT OF THE CRISIS SYSTEM OF CARE; SCREENING, ASSESSMENT, AND OUTPATIENT AND COMMUNITY-BASED EBPS FOR CLIENTS OF ALL AGES; AND MEDICATION-ASSISTED TREATMENT/RECOVERY SERVICES FOR PEOPLE WITH OPIOID USE AND ALCOHOL USE DISORDERS. NCBHS EXPECTS TO REACH 2,520 CHILDREN, YOUTH, AND ADULTS OVER THE COURSE OF THE 4-YEAR GRANT. NCBHS CCBHC HAS FIVE GOALS: (1) ESTABLISHING THE CCBHC INFRASTRUCTURE; (2) ESTABLISHING UNIVERSAL SCREENING, ASSESSMENT, AND MONITORING OF MENTAL HEALTH, SUBSTANCE USE, AND PHYSICAL HEALTH CONDITIONS; (3) ENSURING ACCESS TO INTEGRATED PRIMARY CARE AND BEHAVIORAL HEALTH CARE AND CONTINUITY OF CARE FOR INDIVIDUALS WITH COMPLEX NEEDS; (4) EXPANDING ACCESS TO MEDICATION-ASSISTED TREATMENT/RECOVERY SERVICES FOR INDIVIDUALS WITH IDENTIFIED NEEDS; AND (5) ESTABLISHING A BEHAVIORAL HEALTH URGENT CARE CLINIC MODEL TO DECREASE THE USE OF HOSPITALS AND EMERGENCY ROOMS. NCBHS WILL IMPLEMENT, EXPAND AND ENHANCE NINE REQUIRED SERVICES AS PART OF ITS CCBHC AND WILL HAVE THE ORGANIZATIONAL CAPACITY TO PROVIDE COMPREHENSIVE, COORDINATED, INTEGRATED, CULTURALLY COMPETENT, TRAUMA-INFORMED, RECOVERY-ORIENTED, AND PERSON- AND FAMILY-CENTERED BEHAVIORAL HEALTH SERVICES THAT MEET ALL CCBHC REQUIREMENTS. NCBHS OFFERS AND WILL ENHANCE A COMPREHENSIVE ARRAY OF EVIDENCE-BASED PRACTICES (EBPS) THAT MEET THE CULTURAL AND LINGUISTIC NEEDS OF THE CHILDREN, YOUTH, AND ADULTS IT SERVES. THE ARRAY OF EBPS WILL HELP INDIVIDUALS WITH SMI, SED, SUD, OR COD ACHIEVE THEIR RECOVERY GOALS. NCBHS WILL EXPAND ITS CAPACITY OVER THE 4-YEAR PERIOD TO MEASURE, ASSESS, AND REPORT ON CLIENT OUTCOMES, CLINICAL QUALITY MEASURES, AND ITS PERFORMANCE AS A CCBHC.

SERVICES TO AFGHAN SURVIVORS IMPACTED BY COMBAT INCLUDING WHOLE FAMILY HOLISTIC PSYCHOLOGICAL, PEDIATRIC, SOCIAL, MEDICAL, WELLNESS SERVICES, COMMUNITY ENGAGEMENT AND EDUCATION.

THE PURPOSE OF THIS ACTIVITY IS GENERATING INCLUSIVE ECONOMIC OPPORTUNITIES FOR RURAL COMMUNITIES BY FORMALIZING DIRECT RELATIONSHIPS WITH THEIR SUPPLIERS. BY STREAMLINING THE VALUE CHAIN, WHILE ALSO INCREASING FARMER ACCESS TO KNOWLEDGE AND FINANCIAL SERVICES, FARMERS WILL EARN HIGHER INCOMES AND CONTRIBUTE TO ECONOMIC REVITALIZATION IN THEIR COMMUNITIES.

PORTAGE PATH BEHAVIORAL HEALTH'S CCBHC PDI - SUMMARY: PORTAGE PATH BEHAVIORAL HEALTH (PPBH), LOCATED IN AKRON, OHIO (SUMMIT COUNTY), SEEKS CCBHC PDI FUNDING TO INCREASE ACCESS TO HELP TRANSFORM THE COMMUNITY BEHAVIORAL HEALTH (BH) SYSTEM AND PROVIDE COMPREHENSIVE, COORDINATED BH CARE. DCOS INCLUDE AXESSPOINTE COMMUNITY HEALTH CENTER, GENOA PHARMACY, AND CHILD GUIDANCE & FAMILY SOLUTIONS. POPULATION OF FOCUS: THE POPULATION OF FOCUS WILL BE INDIGENT, LOW- AND MODERATE-INCOME INDIVIDUALS WHO ARE EXPERIENCING SMI, SED, OR COD. THIS FOCUS INCLUDES INCREASING SERVICES TO RACIAL MINORITIES, INCLUDING IMMIGRANTS AND REFUGEES IN NORTH HILL AND OTHER VULNERABLE POPULATIONS SUCH AS THE LGBTQ+ PERSONS. TOTAL NUMBER SERVED OVER FOUR YEARS: 1,650. GOALS AND OBJECTIVES: GOAL 1 OF PPBH'S CCBHC IS TO TRANSFORM THE COMMUNITY BH SYSTEM AND PROVIDE COMPREHENSIVE COORDINATED BH CARE TO INDIVIDUALS ACROSS THE LIFESPAN. GOAL 2 IS TO INCREASE ACCESS TO CARE THROUGH MOBILE SERVICE AND TARGETED CO-LOCATION OF STAFF. GOAL 1, OBJECTIVE 1: 75% OF CCBHC PARTICIPANTS WHO RECEIVE AT LEAST FOUR OF THE CORE SERVICES WILL REPORT A 50% IMPROVEMENT IN THEIR PERCEIVED HEALTH AND WELL-BEING BETWEEN THE ADMINISTRATION OF THE BASELINE NOMS AND THEIR SIX-MONTH FOLLOW-UP NOMS. GOAL 1, OBJECTIVE 2: 100% OF CCBHC PARTICIPANTS WHO IDENTIFY AS HAVING A HOUSING NEED AT THE TIME OF THEIR ASSESSMENT WILL RECEIVE A REFERRAL TO PPBH'S CASE MANAGERS WHO WILL LINK THEM TO HOUSING RESOURCES WITHIN 30 DAYS OF THIS NEED BEING IDENTIFIED. GOAL 1, OBJECTIVE 3: 100% OF CCBHC PARTICIPANTS WILL BE OFFERED LINKAGE TO RECOVERY SUPPORT SERVICES (RSS), INCLUDING PEER SERVICES, WITHIN 10 DAYS OF THEIR ENROLLMENT TO INCREASE THEIR CONNECTION TO RECOVERY AND TO THE RECOVERY COMMUNITIES. 75% WILL REPORT UTILIZATION OF RSS IN THE COMMUNITY AT THE TIME OF THEIR SIX-MONTH REASSESSMENT. GOAL 1, OBJECTIVE 4: 100% OF CCBHC PARTICIPANTS WILL BE OFFERED TARGETED CASE MANAGEMENT AND PSYCHIATRIC REHABILITATION SERVICES TO ASSIST THEM IN PURSUING EDUCATION AND/OR VOCATIONAL NEEDS, IMPROVE THEIR DAILY LIVING SKILLS, AND HELP THEM ENGAGE IN WELLNESS ACTIVITIES THAT SUPPORT RECOVERY. GOAL 2, OBJECTIVE 1: 100% OF CCBHC PARTICIPANTS WILL RECEIVE SERVICES THAT SUPPORT MULTIPLE PATHWAYS OF RECOVERY THAT ARE CULTURALLY COMPETENT, AND PATIENT CENTERED. GOAL 2, OBJECTIVE 2: BY THE END OF Y1, PROVIDE MOBILE BH SERVICES THROUGHOUT THE CATCHMENT AREAS TO DECREASE DISPARITIES AND INCREASE ACCESS TO CARE TO POPULATIONS IN NEED, SERVING AT LEAST 25% OF THE POPULATION THROUGH THE MOBILE UNIT. GOAL 2, OBJECTIVE 3: BY THE END OF Y2, ESTABLISH 8 CO-LOCATIONS OF STAFF WITHIN NON-TRADITIONAL SETTINGS TO INCREASE EQUITY AND ACCESS TO CARE.

CARES FUNDING FOR COVID19. THE SSVF PROGRAM'S PURPOSE IS TO PROVIDE SUPPORTIVE SERVICES GRANTS TO PRIVATE NON-PROFIT ORGANIZATIONS AND CONSUMER COOPERATIVES, WHO WILL COORDINATE OR PROVIDE SUPPORTIVE SERVICES TO VERY LOW-INCOME VETERAN FAMILIES WHO ARE RESIDING IN PERMANENT HOUSING, ARE HOMELESS AND SCHEDULED TO BECOME RESIDENTS OF PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD; OR AFTER EXITING PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD, ARE SEEKING OTHER HOUSING THAT IS RESPONSIVE TO SUCH VERY LOW-INCOME VETERAN FAMILY'S NEEDS AND PREFERENCES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES.

FEMALE SEXUAL ORIENTATION GWAS

INTERNATIONAL PUBLIC HEALTH PROGRAMS FOR THE SURVIVORS OF LANDMINES AND UNEXPLODE

MECHANISTIC CHARACTERIZATION OF UTERINE PAIN (M-CUP) TO IMPROVE DIAGNOSIS AND TREATMENT FOR DYSMENORRHEA

NEURONAL VULNERABILITY TO LIPID DROPLETS AND CHOLESTEROL IN ALZHEIMER'S DISEASE - ABSTRACT ALZHEIMER'S DISEASE (AD) IS A DEVASTATING NEURODEGENERATIVE DISORDER THAT AFFLICTS OVER 6.5 MILLION AMERICANS. DESPITE DECADES OF RESEARCH ON AMYLOID-SS (ASS) AND TAU LESIONS, EFFECTIVE TREATMENT REMAINS OUT OF REACH. MOUNTING AD GENOME-WIDE ASSOCIATION STUDIES (GWAS) RISK LOCI PROVIDE OPPORTUNITIES FOR UNDERSTANDING DISEASE BIOLOGY AND DEVELOPING EFFECTIVE TREATMENT. MULTIPLE AD GWAS RISK GENES, SUCH AS APOE, ARE PIVOTAL FOR LIPID METABOLISM THAT IS ESSENTIAL TO BRAIN HEALTH AND DISEASE. UNDER STRESS OR IN THE AGING BRAIN, BOTH ASTROCYTES AND MICROGLIA SHOW ABNORMAL LIPID METABOLISM AND ACCUMULATION OF LIPID DROPLETS (LD). ALTHOUGH GLIAL LD ARE KNOWN TO BE LARGELY NEUROPROTECTIVE, LD FORMATION IN HUMAN NEURONS AND ITS CELLULAR AND MOLECULAR RAMIFICATIONS ARE LESS CLEAR. WITH EXCITATORY NEURONS (EX) DERIVED FROM HUMAN INDUCED PLURIPOTENT STEM CELLS (IPSC), WE HAVE SHOWN THAT APOE4 EX NEURONS CO-CULTURED WITH ASTROCYTES ACCUMULATED MORE LD THAN APOE2/3 NEURONS. OUR SINGLE-CELL TRANSCRIPTOMIC ANALYSIS OF AD BRAIN ALSO IDENTIFIED AN IMPAIRED NEURON- OLIGODENDROCYTE PRECURSOR CELL (OPC) COMMUNICATION MEDIATED BY APOE AND ITS RECEPTOR LDLR. INTERESTINGLY, NEURAL CHOLESTEROL WAS RECENTLY FOUND TO BE ESSENTIAL TO OPC PROLIFERATION AND REMYELINATION. WE THUS HYPOTHESIZE THAT ABNORMAL NEURONAL LD AND CHOLESTEROL IN AD CONTRIBUTE TO NEURONAL DAMAGE AND IMPAIRED NEURON REMYELINATION. LEVERAGING OUR EXPERTISE ON USING IPSC-DERIVED NEURONS AND CORTICAL ORGANOIDS AS CELLULAR MODELS FOR BRAIN DISORDERS, WE WILL CHARACTERIZE THE CELL TYPE VULNERABILITY TO LD/CHOLESTEROL AND THE CORRESPONDING EPIGENOMIC/TRANSCRIPTOMIC CHANGES IN THE CONTEXT OF AD RISK ALLELES. IN AIM 1, TO DETERMINE THE NEURAL VULNERABILITY TO LD AND ITS CLINICAL RELEVANCE IN AD, WE WILL CO-CULTURE EX AND INHIBITORY (INH) NEURONS OF A COHORT OF 60 PATIENT-SPECIFIC IPSC LINES, AND ASSAY NEURAL LD, FREE FATTY ACIDS, CHOLESTEROL, AND NEURAL MORPHOMETRICS, WHICH WILL THEN BE ASSOCIATED WITH APOE ALLELES AND NON-APOE AD POLYGENIC RISK SCORES. THESE CELLULAR PHENOTYPES WILL ALSO BE CORRELATED WITH PATIENTS’ LONGITUDINAL PLASMA LIPID LEVELS AND OTHER CLINICAL OUTCOMES. IN AIM 2, TO UNDERSTAND MOLECULAR MECHANISMS UNDERLYING NEURAL VULNERABILITY TO LD, WE WILL PERFORM SINGLE-CELL RNA/ATAC-SEQUENCING ON THE SAME NEURAL CO-CULTURES USED IN AIM 1 TO IDENTIFY GENES WITH CHROMATIN ACCESSIBILITY AND TRANSCRIPTION CORRELATED WITH CELLULAR LD IN EACH CELL TYPE. IN AIM 3, TO EXAMINE THE EFFECT OF AD RISK ALLELES ON CHOLESTEROL-MEDIATED NEURON-OPC COMMUNICATION AND MYELINATION, WE WILL FIRST USE CRISPR EDITING TO GENERATE ISOGENIC IPSC LINES CARRYING AD RISK ALLELES AND THEN DIFFERENTIATE THEM INTO MYELINATING CEREBRAL ORGANOIDS. WE WILL EXAMINE THE EFFECTS OF AD RISK ALLELES ON NEURONAL CHOLESTEROL LEVELS AS WELL AS THE OPC PROLIFERATION AND NEURON MYELINATION. THIS STUDY WILL SIGNIFICANTLY ADVANCE OUR UNDERSTANDING OF THE CELLULAR AND MOLECULAR MECHANISMS OF NEURONAL VULNERABILITY TO ABNORMAL LD AND CHOLESTEROL IN AD.

HOMELESS PREVENTION

IDENTIFYING THE CONTRIBUTIONS OF GESTATIONAL AND CAREGIVING ENVIRONMENTS TO SOCIOECONOMIC DISPARITIES IN CHILD LANGUAGE AND COGNITIVE DEVELOPMENT. - PROJECT SUMMARY/ABSTRACT IN THE UNITED STATES, CHILDREN’S DEVELOPMENT DIFFERS MARKEDLY AS A FUNCTION OF THEIR FAMILY’S SOCIOECONOMIC STATUS (SES). SOME OF THE MOST PRONOUNCED AND CONSEQUENTIAL SES DISPARITIES ARE IN LANGUAGE AND COGNITIVE DEVELOPMENT, WHICH ARE EVIDENT AS EARLY AS TWO YEARS OF AGE AND, BY KINDERGARTEN ENTRY, PREDICT WITH DEPRESSING ACCURACY CHILDREN’S LONG-TERM ACADEMIC TRAJECTORIES. YET WHILE SOCIAL SCIENCE HAS IDENTIFIED A VARIETY OF STRUCTURAL, CONTEXTUAL, AND PSYCHOLOGICAL FACTORS THAT CONTRIBUTE TO DISPARITIES IN CHILD DEVELOPMENT, WE HAVE LIMITED UNDERSTANDING OF HOW THESE FACTORS “GET UNDER THE SKIN” TO INFLUENCE BIOLOGICAL PROCESSES THAT ARE PROXIMALLY INVOLVED IN BRAIN MATURATION AND SHAPE KEY DEVELOPMENTAL OUTCOMES. THIS PROPOSAL INTEGRATES APPROACHES TO UNDERSTANDING DEVELOPMENTAL DISPARITIES FROM THE BIOLOGICAL AND PSYCHOLOGICAL SCIENCES. THEORISTS IN THE BIOLOGICAL SCIENCES HAVE PROPOSED THAT DISADVANTAGE GETS BIOLOGICALLY EMBEDDED DURING GESTATION, IN PART VIA IMMUNE RESPONSES TO STRESS THAT RESULT IN “ADVERSE GESTATIONAL ENVIRONMENTS” (AGES). ANIMAL STUDIES HAVE CONFIRMED THAT STRESSFUL EXPOSURES CAN CONTRIBUTE TO ADVERSE GESTATIONAL ENVIRONMENTS AND TO SUBSEQUENT OXIDATIVE NEURONAL INJURY AND IMPAIRED DEVELOPMENT, YET HUMAN STUDIES HAVE YET TO EXAMINE WHETHER AGES ARE ASSOCIATED WITH SOCIOECONOMIC DISPARITIES IN LANGUAGE AND COGNITION. WE LEVERAGE AN EXISTING NIH-FUNDED STUDY OF DISPARITIES IN PERINATAL OUTCOMES, WHERE IN-DEPTH ASSESSMENTS OF SES AND THE GESTATIONAL ENVIRONMENT ARE BEING PERFORMED IN 600 PREGNANT INDIVIDUALS FROM DIVERSE BACKGROUNDS. WE WILL FOLLOW CHILDREN BORN TO THESE INDIVIDUALS, COLLECTING MEASURES OF COGNITIVE AND LANGUAGE DEVELOPMENT DURING THE INFANT-TODDLER PERIOD AS WELL AS PRESCHOOL OUTCOMES AT AGE 5 YEARS. AIM 1 WILL DETERMINE IF ADVERSE GESTATIONAL ENVIRONMENTS RESULTING FROM MATERNAL STRESS MEDIATE SOCIOECONOMIC DISPARITIES IN CHILD LANGUAGE AND COGNITIVE DEVELOPMENT. AIM 2 WILL DEEPEN UNDERSTANDING INTO THE PLACENTAL CHARACTERISTICS OF ADVERSE GESTATIONAL ENVIRONMENTS THAT ARE ASSOCIATED WITH LOWER LANGUAGE AND COGNITIVE DEVELOPMENT. AIM 3 WILL EXAMINE THE COMBINED CONTRIBUTIONS OF AGES AND POSTNATAL CAREGIVING ENVIRONMENTS IN PREDICTING LANGUAGE AND COGNITIVE DEVELOPMENT. ACROSS THESE AIMS, WE UTILIZE STATE-OF-THE-ART METHODS FROM THE SOCIAL, BEHAVIORAL, AND BIOLOGICAL SCIENCES, AND ADOPT A CULTURALLY AND LINGUISTICALLY RESPONSIVE APPROACH TO ASSESSMENT OF CHILD LANGUAGE AND COGNITIVE DEVELOPMENT. THIS STUDY WILL ANSWER KEY QUESTIONS ABOUT THE ORIGINS OF SES DISPARITIES IN LANGUAGE AND COGNITIVE DEVELOPMENT THAT HAVE IMPORTANT IMPLICATIONS FOR THEORY, POLICY, AND PRACTICE.

PORTABLE HAZARDOUS AGENT DETECTION - PHASE 2 (PHAD - 2)

DIRECT SERVICES FOR SURVIVORS OF TORTURE, INCLUDING HOLISTIC PSYCHOLOGICAL, SOCIAL, LEGAL, MEDICAL SERVICES, AND TRAINING.

SURVIVORS OF TORTURE, INTERNATIONAL WILL PROVIDE TORTURE SURVIVORS AND THEIR FAMILIES WHO LIVE IN SAN DIEGO AND IMPERIAL COUNTY HEAL PHYSICALLY, PSYCHOLOGICALLY AND SOCIALLY; AND LEAD MEANINGFUL LIVES

BUILDING CAPACITY OF THE INSTITUT PASTEUR DE COTE D'IVOIRE TO PROVIDE QUALITY LABORATORY DIAGNOSIS AND SURVEILLANCE OF OPPORTUNISTIC INFECTIONS RELATED TO HIV - SINCE 2004, USG IS SUPPORTING COTE D'IVOIRE TO DEVELOP CLINICAL LABORATORY NETWORK TO REDUCE HIV AIS BURDEN AND STRENGTHEN LABORATORY SYSTEM. THESE SUPPORTS HELP CTE D'IVOIRE TO UNDERSTAND THE INPORTANCE OF HAVING TIERED FUNCTIONING CLINICAL LABORATORY WITHN THE HEALTH SYSTEM. SEVERAL PILAR OF IVORIAN LABORATORY SYSTEM ARE STILL WEAK DESPITE THE ENORMOUS EFFORT MADE BY INTERNATIONAL STAKEHOLDERS AND WILL NEED ADDITIONNAL SUPPORT FOR THE SYSTEM TO RESPOND TO NATIONAL AND INTERNATIONAL STANDARDS. THESE ARE A LABORATORY MANAGEMENT SYSTEM, HUMAN RESOURCE CAPACITY BUILDING IN CERTAIN AREA. INFRASTRUCTURE AND EQUIPMENT MAINTENANCE, BIODAFETY AND BIOSERCURITY AND PROCUREMENT. UNDER THIS PROJECT, BASICALLY, OUR OBJECTIVES ARE DECLINES ARROUND THREE STRATEGIES INCLUDING FOLLOWING ELEMENTS: - SUSTAIN AND EXPAND LABORATORY SERVICES AND INFRASTRUCTURE FOR MICROBIOLOGY TESTS STIS AND OTHER IOS) AT REGIONAL HOSPITAL LABORATORY AND CATS (I) SUPPORT CENTRAL LABORATORY TO SUSTAIN TB LABS ACTIVITIES (II)SUPPORT CATS TO IMPROVE MICROSCOPY AND MOLECULAR TESTS XPERT (III)STRENGTHEN TB LABS FOR DATA COLLECTION AND MANAGEMENT (IV)SUPPORT MICROBIOLOGY ACTIVITIES (STI IOS) -- EXTEND AND SUSTAIN ACCESS TO HIGH QUALITY LABORATORY SERVICES FOR PATIENT WITH ADVANCED HIV DISEASE AT SELECTED CLINICAL SITES. (I) DEVELOP AND REVIEW PROCEDURES AND TRAINING MATERIAL FOR ADVANCED HIV DISEASE PATIENT TESTING (XPERT ULTRA, LF-LAM, AND CRYPTOCOCCAL ANTIGEN RAPID TEST, ETC.) (II) IMPLEMENT STANDARD OPERATING PROCEDURES (SOPS) FOR LABORATORY TESTING AT EACH CLINICAL AND LABORATORY SITE, (III) SUPPORT DATA COLLECTION, MONITORING AND EVALUATION OF THE PROGRAM. IMPLEMENT A QUALITY MANAGEMENT SYSTEM FOR TB AND MICROBIOLOGY LABORATORY SERVICES TO SUPPORT LABORATORY ACCREDITATION (I) DEVELOP AND/OR REVISE DOCUMENTS, SOPS, AND GUIDELINES FOR TB AND MICROBIOLOGY LABORATORY EXTERNAL QUALITY ASSURANCE (EQA) PROGRAMS, (II) SUPPORT EQA FOR PROGRAMS, FOR TB, OIS, STI, LF-LAM AND EQA PROGRAM AND MICROBIOLOGY TESTS, (III) SUPPORT THE CENTRAL LABORATORIES OF IPCI AND CEDRES FOR COMPLIANCE TO THE WHO/AFRO ACCREDITATION SHEME AT THE OF THE PROJECT, EXPECTED OUTCOME WILL INCLUDE AVAILABILITY OF INCREASZ AVAILABILITY OF LABOROTORY SERVICES AND DIADNOSTICS FOR STIS, TB (GENEXPERT, CULTURE, LINE PROBE ASSAYS, MICROSCOPY), AND OTHER OIS, IMPROVE STANDARDIZATION AND HARMONIZATION OF LAB ACTIVITIES BY PROCEDURES ND GUIDELINE DEVELOPMENT, IMPROVE PROCUREMENT OF LAB COMMODITIES TO ASSURE CONTINOUS ACTIVITIES INCREASE COMPETENCY OF CLINICAL SITES PERFORMING ACCURATE RAPID TESTING FOR TB, STI AND OIS DIAGNOSTICS IPCI WILL IMPLEMENT THE PROJECT ACTIVITIES UNDER THE COLLABORATIVE SUPPORT OF THE NATIONAL TB CONTROL PROGRAM, THE AIDS PROGRAM THE NATIONAL PUBLIC HEALTH LABORATORY AND WITH THE TECHNICAL ASSISTANCE OF CDC PARTNERS AND COTE D IVOIRE PEPFAR IMPLEMENTING PARTNERS. MINISTRY OF HEALTH AND AIDS OF THE GOVERMENT OF CTE D'IVOIRE WILL BE INVOLVED IN THE PRESENT PROJCET FOR THE PROMOTION OF LABORATARY ACTIVITIES DECENTRALIZATION

COMMUNITY CLINICAL ONCOLOGY PROGRAM

THE PURPSE OF THIS MODIFICATION IS TO OBLIGATE $390,000

ROLE OF INTERNEURONS IN BRAIN TISSUE OXYGEN REGULATION

IMPROVED DETECTION OF CEREBRAL METASTASES USING A USING A NOVEL T1 RELAXATION-ENHANCED STEADY-STATE (T1RESS) MRI TECHNIQUE - CONTRAST-ENHANCED MAGNETIC RESONANCE IMAGING (MRI) IS THE CORNERSTONE FOR BRAIN TUMOR DIAGNOSIS AND TREATMENT PLANNING. WHILE ITS SENSITIVITY FOR METASTASES IS SUPERIOR TO THAT OF CT OR PET-CT, SMALL LESIONS (<5- MM) AND LEPTOMENINGEAL SPREAD MAY STILL BE MISSED, WHICH CAN HAVE A MAJOR IMPACT ON PROGNOSIS AND PLANNING FOR STEREOTACTIC RADIOSURGERY, AS WELL AS ON THE USE OF TARGETED BIOLOGICS THAT CROSS THE BLOOD-BRAIN BARRIER. A METHOD THAT COULD FURTHER IMPROVE THE SENSITIVITY AND SPECIFICITY OF MRI FOR BRAIN TUMORS WOULD BE OF GREAT CLINICAL BENEFIT. TOWARDS THIS END, WE HAVE DEVELOPED A NEW CLASS OF PULSE SEQUENCES, CALLED T1 RELAXATION-ENHANCED STEADY-STATE (T1RESS), THAT GREATLY IMPROVES THE VISIBILITY OF TUMORS IN CONTRAST- ENHANCED MRI. COMPARED WITH EXISTING NEUROIMAGING TECHNIQUES, T1RESS AT LEAST DOUBLES THE TUMOR-TO- BACKGROUND CONTRAST WHILE SIGNIFICANTLY IMPROVING THE TUMOR-TO-BACKGROUND CONTRAST-TO-NOISE RATIO. AN “UNBALANCED” VERSION (UT1RESS) RENDERS BLOOD VESSEL DARK AND IS THE FOCUS OF OUR PROPOSAL. IN A PRELIMINARY STUDY OF 54 ADULT PATIENTS THAT WAS PUBLISHED IN SCIENCE ADVANCES, UT1RESS PROVIDED A REMARKABLE TWOFOLD OR GREATER IMPROVEMENT IN TUMOR-TO-BRAIN CONTRAST ALONG WITH A MARKED IMPROVEMENT IN LESION-TO-BRAIN CONTRAST-TO-NOISE IN COMPARISON TO STANDARD-OF-CARE MPRAGE AND OTHER PULSE SEQUENCES THAT ARE COMMONLY USED TO IMAGE BRAIN TUMORS. WE FOUND THAT EVEN SMALL METASTATIC TUMOR DEPOSITS AND LEPTOMENINGEAL LESIONS THAT WERE DIFFICULT TO DISTINGUISH FROM SMALL BLOOD VESSELS WITH STANDARD IMAGING TECHNIQUES COULD BE UNAMBIGUOUSLY IDENTIFIED. THE PRIMARY HYPOTHESIS OF THIS FIVE-YEAR GRANT PROPOSAL IS THAT T1RESS WILL SIGNIFICANTLY IMPROVE THE SENSITIVITY FOR SMALL BRAIN METASTASES COMPARED WITH EXISTING MRI PULSE SEQUENCES, WHILE ALSO REDUCING SCAN TIMES. A SECONDARY HYPOTHESIS IS THAT THE TWOFOLD IMPROVEMENT IN TUMOR-TO-BRAIN CONTRAST OBTAINED WITH UT1RESS CAN BE USED TO ENABLE A SUBSTANTIAL TWOFOLD REDUCTION IN GADOLINIUM-BASED CONTRAST AGENT (GBCA) DOSAGE. STUDIES OF PHANTOMS, HEALTHY VOLUNTEERS, AND PATIENTS WITH BRAIN TUMORS ALONG WITH BLOCH EQUATION MODELING WILL BE USED TO GUIDE SEQUENCE OPTIMIZATION. THESE OPTIMIZATION EFFORTS WILL BE FOLLOWED BY A TWO- INSTITUTION STUDY TO DETERMINE THE ACCURACY OF THE TECHNIQUE. OUR SPECIFIC AIMS ARE AS FOLLOWS: 1. TO APPLY UT1RESS IN HEALTHY SUBJECTS AND PATIENTS WITH BRAIN TUMORS TO SYSTEMATICALLY EVALUATE THE IMPACT OF VARIOUS SEQUENCE PARAMETERS ON IMAGE APPEARANCE, CONTRAST, SNR, AND LESION SHARPNESS, AND TO OPTIMIZE THE TECHNIQUE TO MAXIMIZE TUMOR VISIBILITY WHILE MINIMIZING SCAN TIME AND IMAGE ARTIFACTS. 2. TO PERFORM A PILOT STUDY TO DETERMINE WHETHER METRICS OF TUMOR VISIBILITY USING UT1RESS AND A TWOFOLD REDUCED GBCA CONTRAST AGENT DOSAGE ARE NONINFERIOR TO MPRAGE WITH A STANDARD CONTRAST AGENT DOSAGE. 3. TO PERFORM A TWO-SITE RESEARCH TRIAL AT 3T TO CHARACTERIZE THE APPEARANCE OF BRAIN METASTASES WITH UT1RESS, AND TO DETERMINE ITS ACCURACY FOR SMALL BRAIN METASTASES COMPARED TO STANDARD-OF-CARE MPRAGE.

DIRECT SERVICES FOR SURVIVORS OF TORTURE, INCLUDING HOLISTIC PSYCHOLOGICAL, SOCIAL, LEGAL, MEDICAL SERVICES AND TRAINING.

INFLAMMATORY PATHWAYS IN BPH/LUTS

CONCERNS OF POLICE SURVIVORS NATIONAL OUTREACH PROGRAMS

VITAMIN D AND PROGESTINS FOR THE CHEMOPREVENTION OF FALLOPIAN TUBE/OVARIAN CANCER

HOMELESS PREVENTION

DEVELOPMENT OF SUPR PEPTIDES AS PET IMAGING AGENTS FOR HER2+ BREAST CANCER

PROJECT DESCRIPTION: ENDEAVOR HEALTH AIMS TO DEVELOP AND IMPLEMENT A HOSPITAL-BASED COMMUNITY VIOLENCE INTERVENTION PROGRAM, ENDEAVOR TO HEAL, AT THREE OF THEIR EIGHT HOSPITALS ON CHICAGO, ILS NORTH SIDE AND NORTH SUBURBS (SWEDISH HOSPITAL, EVANSTON HOSPITAL AND HIGHLAND PARK HOSPITAL). THE ENDEAVOR TO HEAL PROGRAMS GOAL IS TO DECREASE INSTANCES OF VIOLENT INJURY WITHIN HIGH-CRIME NEIGHBORHOODS IN THE ENDEAVOR HEALTH SERVICE AREA, THEREBY CONTRIBUTING TO AN OVERALL REDUCTION IN VIOLENT CRIME IN CHICAGO, AND ITS SURROUNDING SUBURBS BY USING A SYSTEMATIC APPROACH THAT INCORPORATES COLLABORATIVE PARTNERSHIPS, COMMUNITY ENGAGEMENT, AND EVIDENCE-BASED VIOLENCE PREVENTION AND INTERVENTION METHODS. THE CORE STRATEGIES TO MEET THESE OBJECTIVES INCLUDE: RAPID RESPONSE AND CRISIS INTERVENTION, INTENSIVE CASE MANAGEMENT, MENTAL HEALTH SERVICES, HOSPITAL-COMMUNITY COLLABORATION, AND WORKFORCE DEVELOPMENT. ENDEAVOR TO HEAL DEFINES THE TARGET POPULATION AND HIGH-RISK INDIVIDUALS (ADULTS AND YOUTH OVER THE AGE OF 16) AS THOSE WHO HAVE EXPERIENCED VIOLENT INJURY, SUCH AS GUNSHOT WOUNDS, STABBINGS, OR PHYSICAL ASSAULT, AND ARE ADMITTED TO ONE OF THE THREE PARTICIPATING HOSPITALS. THE PROGRAM WILL ALSO CONSIDER INDIVIDUALS WITH A HISTORY OF VIOLENT VICTIMIZATION OR INVOLVEMENT IN COMMUNITY VIOLENCE TO BE AT HIGH RISK. ENDEAVOR HEALTH HAS SUBSTANTIAL EXPERIENCE WORKING DIRECTLY WITH SURVIVORS OF VIOLENCE THROUGH BOTH MEDICAL INTERVENTION AND PROGRAMMATIC INITIATIVES AIMED AT PREVENTION AND INTERVENTION AND WILL BUILD SUPPORTIVE SERVICES FOR VICTIMS OF VIOLENT INJURY THROUGH INDIVIDUALIZED TREATMENT PLANS, ACCESS TO INDIVIDUAL AND GROUP THERAPY, ENGAGEMENT IN COMMUNITY-BASED AGENCIES DEDICATED TO ADDRESSING SOCIAL DETERMINANTS AND EQUITY IN CARE, AND OTHER SERVICES AIMED AT REDUCING RISK OF REINJURY. THE ENDEAVOR TO HEAL PROGRAM WILL ADDRESS HEALTHCARE DISPARITIES ACROSS THE CARE CONTINUUM THROUGH PARTNERSHIP WITH COMMUNITY ORGANIZATIONS THAT SHARE OUR VISION TO IMPROVE EQUITABLE HEALTH OUTCOMES AND WILL CONDUCT A PROCESS AND OUTCOMES EVALUATION TO ASSESS PROGRAMMATIC SUCCESS.

ZERO SUICIDE INITIATIVE - ENDEAVORS’ ZERO SUICIDE INITIATIVE SEEKS TO CHANGE THE TRAJECTORY AND ACCELERATE POSITIVE OUTCOMES BY TRAINING BOTH CLINICAL AND FRONT-LINE STAFF (RECEPTIONISTS, INTAKE WORKERS, HOUSING COUNSELORS) WHO ARE TYPICALLY THE FIRST TO ENCOUNTER THE PUBLIC. THESE INDIVIDUALS WILL BE TRAINED TO ASK BRIEF, RELEVANT QUESTIONS OF ALL ADULTS AGE 25 OR OLDER AND, WHEN INDICATED, CONNECT THEM TO A CASE MANAGER OR CLINICIAN FOR A RISK ASSESSMENT AND THE PROVISION OR COORDINATION OF TREATMENT. TWO SIGNIFICANT OUTCOMES WILL ACCRUE: SCREENING WILL MOVE UPSTREAM, CREATING AN OPPORTUNITY FOR EARLY INTERVENTION, AND IDENTIFICATION OF NEED, AND ACCESS TO CARE WILL BE ENHANCED FOR RURAL RESIDENTS AND OTHER UNRECOGNIZED, AT-RISK INDIVIDUALS.

MOLECULAR CONTROL OF EGF RECEPTOR DOWN-REGULATION

ANTI-INFECTIVE STEWARDSHIP USING THE WISCA TOOL IN THE ELECTRONIC MEDICAL RECORD

SYSTEMIC DELIVERY OF AN ONCOLYTIC ADENOVIRUS TARGETING TGF? TO ENHANCE ANTI-PD-1 AND ANTI-CTLA-4 THERAPY FOR TRIPLE NEGATIVE BREAST CANCER - PROJECT SUMMARY THE DEVELOPMENT OF NOVEL THERAPIES FOR THE TREATMENT OF BREAST CANCER IS A MAJOR UNMET NEED. IN RECENT YEARS, IMMUNE CHECKPOINT INHIBITORS INCLUDING ANTI-PD-1, ANTI-PD-L1 AND ANTI-CTLA-4 HAVE SHOWN PROMISE AS ANTITUMOR AGENTS, AND ARE APPROVED FOR THE TREATMENT OF SEVERAL MALIGNANCIES. CLINICAL TRIALS IN BREAST CANCER PATIENTS HAVE SHOWN THAT ABOUT 20% OF TRIPLE NEGATIVE BREAST CANCERS (TNBC) RESPOND FAVORABLY TO ANTI-PD-1 ANTIBODIES AND ATEZOLIZUMAB, AN ANTI-PD-L1 ANTIBODY IN COMBINATION WITH NAB-PACLITAXEL (ABRAXANE) IS NOW FDA APPROVED FOR ADVANCED STAGE TNBC PATIENTS WITH POSITIVE PDL-1 EXPRESSION. HOWEVER, MANY TNBC PATIENTS ARE RESISTANT TO ANTI-PD-1/PDL-1 AND ANTI-CTLA-4 TREATMENTS WHICH COULD BE DUE TO WEAK IMMUNOGENICITY OF THE TUMORS AND POOR INFLAMMATORY BUT HIGHLY IMMUNE SUPPRESSIVE TUMOR MICROENVIRONMENT. IN RECENT YEARS TGFSS HAS BEEN SHOWN TO BE A STRONG IMMUNE SUPPRESSOR AND CAN POTENTIALLY PRODUCE A TUMOR MICROENVIRONMENT THAT IS RESISTANT TO ANTI-PD-1 AND ANTI-CTLA-4 THERAPY. TO OVERCOME RESISTANCE TO ANTI-PD-1 AND ANTI-CTLA-4 WE HAVE DEVELOPED ADENOVIRUSES (AD) EXPRESSING STGFSSRIIFC (SOLUBLE TGFSS RECEPTOR II FUSED WITH HUMAN IGG FC). STGFSSRIIFC ACTS AS A TGFSS DECOY, AND CAN INHIBIT TGFSS PATHWAYS. INITIALLY, WE CREATED AD5 BASED AD.ST EXPRESSING STGFSSRIIFC. TO REDUCE HEPATIC/SYSTEMIC TOXICITY ASSOCIATED WITH SYSTEMIC DELIVERY OF AD.ST, WE CREATED MHAD.ST, A LIVER-DETARGETED VIRUS, BY REPLACING HYPERVARIABLE REGIONS (HVRS) (1-7) OF AD.ST WITH AD48 HVRS. TO ENHANCE TUMOR SPECIFICITY, WE HAVE NOW CREATED MHADLYP.ST BY INTRODUCING LYP-1 PEPTIDE, A 9-AMINO ACID LONG TUMOR HOMING-CELL PEPTIDE, INTO THE HI LOOP OF THE MHAD.ST FIBER. IN THIS PROPOSAL, WE WILL TEST THE HYPOTHESES THAT SYSTEMIC ADMINISTRATION OF MHADLYP.ST IN MICE BEARING 4T1 TRIPLE NEGATIVE MAMMARY TUMORS WILL RESULT IN REDUCED HEPATIC/SYSTEMIC TOXICITY BUT PRODUCE HIGH LEVELS OF STGFSSRIIFC AND INHIBIT TGFSS PATHWAYS. THIS WILL ALTER THE TUMOR MICROENVIRONMENT, INDUCE TUMOR IMMUNITY, AND OVERCOME RESISTANCE TO ANTI-PD-1 AND ANTI-CTLA-4., AND EXAMINE THE EXPRESSION PROFILES OF TGFSS-1, TGFSS-1 REGULATED GENES, AND PD-1 AND CTLA-4 SIGNALING PATHWAYS. WE WILL EXAMINE IMMUNO-PHENOTYPES IN TUMORS, PERIPHERAL BLOOD AND SPLEEN (AIM 1). NEXT, WE WILL EXAMINE MHADLYP.ST, ANTI-PD-1 AND ANTI-CTLA-4 COMBINATION THERAPIES IN MOUSE TUMOR MODELS. WE WILL CONDUCT RNA-SEQ ANALYSIS OF THE WHOLE TRANSCRIPTOMES, AND EXAMINE THE ROLE OF IMMUNE ACTIVATION IN MEDIATING THE ANTI-TUMOR RESPONSES (AIM 2). WE WILL TEST THE HYPOTHESIS THAT SYSTEMIC ADMINISTRATION OF MHLYPAD.ST, IN COMBINATION WITH ANTI-PD-1 AND ANTI- CTLA-4 IN MICE WITH PRE-ESTABLISHED METASTASES WILL BE EFFECTIVE (AIM 3). TO GUIDE US FOR THE COMBINATION THERAPY TRIALS WITH MHADLYP.ST, ANTI-PD-1 AND ANTI-CTLA-4, WE WILL EXAMINE HUMAN TNBC TUMORS BY NANOSTRING TECHNOLOGY FOR RNA PROFILING, AND WILL FURTHER EXAMINE THE TGFSS-1 AND OTHER RELEVANT BIOMARKERS AND TILS IN HUMAN TNBC TUMORS. WE WILL ALSO SCREEN THE HUMAN POPULATION FOR THE AD NEUTRALIZING ANTIBODIES TITERS (AIM 4). WE BELIEVE THAT OUR RESEARCH DESCRIBED HERE IS CRITICAL TO BRING FORWARD OUR ONCOLYTIC VIRUS MHADLYP.ST TARGETING TGFSS IN COMBINATION WITH ANTI-PD-1 AND ANTI-CTLA-4 FOR CLINICAL EVALUATION IN TNBC PATIENTS.

NONENHANCED 3T QISS MR ANGIOGRAPHY OF THE PERIPHERAL ARTERIES

EFFECTS OF TNF BLOCKADE ON HUMAN BPH/LUTS - SUMMARY BENIGN PROSTATIC HYPERPLASIA (BPH) AND ASSOCIATED LOWER URINARY TRACT SYMPTOMS (LUTS) ARE A MAJOR CAUSE OF MORBIDITY IN AGING MEN, RESULTING IN MAJOR ECONOMIC COSTS IN BOTH DIRECT HEALTHCARE EXPENDITURE AS WELL AS LOST PRODUCTIVITY. THE PATHOGENESIS OF BPH/LUTS IS MULTIFACTORIAL. HOWEVER, CURRENT MEDICAL BPH TREATMENT GENERALLY FOLLOWS A SCRIPTED FORMAT USING TWO APPROACHES: -ADRENERGIC BLOCKERS (-BLOCKERS) TO RELAX MUSCLE TONE AND 5- REDUCTASE INHIBITORS (5ARI) TO SHRINK THE PROSTATE. MANY MEN FAIL THESE MEDICAL TREATMENTS, RESULTING IN AROUND 120,000 SURGICAL INTERVENTIONS ANNUALLY IN THE UNITED STATES. COMMON PRO-INFLAMMATORY CO-MORBIDITIES INCLUDE OBESITY AND DIABETES. INFLAMMATION IS STRONGLY ASSOCIATED WITH INCREASED LUTS SEVERITY AND ALSO WITH THE FAILURE OF EXISTING MEDICAL TREATMENTS FOR BPH RESULTING IN PROGRESSION TO SURGERY. LINKS BETWEEN AUTOIMMUNE INFLAMMATORY (AI) DISEASES AND BPH ARE NOW WELL ESTABLISHED WITH COMMON COMORBIDITIES INCLUDING PSORIASIS AND RHEUMATOID ARTHRITIS. AI DISEASE PATIENTS HAVE AROUND A 50% INCREASE IN BPH PREVALENCE. WE RECENTLY SHOWED THAT AI DISEASE TREATMENT, SPECIFICALLY WITH TNF-ANTAGONISTS, REDUCED SUBSEQUENT BPH DIAGNOSES DOWN TO OR EVEN BELOW THE BASELINE POPULATION INCIDENCE. THIS EFFECT WAS NOT OBSERVED WITH THE BROAD SPECTRUM IMMUNE-SUPPRESSANT METHOTREXATE. WE ALSO SHOWED BOTH SUPPRESSION OF THE DEVELOPMENT OF PROSTATE HYPERPLASIA AND THE SHRINKAGE OF EXISTING ENLARGED GLANDS IN MOUSE MODELS TREATED WITH TNF-ANTAGONISTS. THE PROSTATES OF PATIENTS TREATED WITH THESE AGENTS DEMONSTRATE REDUCED PROLIFERATION AND INFLAMMATION. THIS STRONGLY SUGGESTS THAT APPROACHES THAT TARGET IMMUNOMODULATORY PATHWAYS, SPECIFICALLY TNF BLOCKADE, MAY BE BENEFICIAL IN THE PREVENTION AND/OR TREATMENT OF BPH/LUTS. PATHWAY ANALYSIS IN TNF-ANTAGONIST-TREATED MOUSE MODELS DEMONSTRATED THAT BLOCKADE OF THIS PATHWAY REDUCES ANTIGEN PRESENTATION AND INFLAMMATORY SIGNALING DOWNSTREAM OF TNF RECEPTOR 2. OVERALL THESE CHANGES WERE CONSISTENT WITH TNF BLOCKADE REDUCING BOTH OVERALL CELLULAR PROLIFERATION AND THE SUPPRESSION OF APOPTOSIS. THERE ARE LIMITED MEDICAL OPTIONS TO TREAT PATIENTS WITH BPH/LUTS AND NO NEW MEDICAL TREATMENTS HAVE BEEN DEVELOPED IN NEARLY 30 YEARS. THIS PROPOSAL WILL TEST THAT IDEA IN A PILOT TRIAL WITH SUBSEQUENT TISSUE AND GENOMIC ANALYSIS TO IDENTIFY PATHWAYS THAT MAY BE CONCURRENTLY TARGETED AS WELL AS PROVIDE DATA TO ASSIST IN FUTURE PATIENT STRATIFICATION. THE MAJOR IMPACT OF THIS WORK WILL BE TO TEST AN EXISTING AND WIDELY USED DRUG AS A POSSIBLE NOVEL APPROACH TO TREAT BPH. IF SUCCESSFUL, THIS WORK WOULD SET THE STAGE FOR INTEGRATING A NEW APPROACH WITH EXISTING THERAPIES FOR THE BPH/LUTS PATIENT POPULATION WITH LARGE PROSTATES. WE WILL PURSUE THREE AIMS, THAT WILL: 1) EVALUATE THE EFFICACY OF TNF ANTAGONIST ACTION IN BPH/LUTS, 2) DEFINE THE CONSEQUENCES OF TNF ANTAGONIST THERAPY ON HUMAN PROSTATE TISSUE, AND, 3) IDENTIFY GENETIC PREDICTORS TO STRATIFY PATIENTS WITH DIFFERENTIAL RESPONSE TO TNF ANTAGONISTS.

RAPID REAL-TIME MR ANGIOGRAPHY OF SUSPECTED STROKE

PROJECTS TO ASSIST AMERICA'S LAW ENFORCEMENT SURVIVING FAMILIES TO REBUILD THEIR SHATTERED LIVES

SUSTAINING INFLUENZA SURVEILLANCE NETWORKS AND RESPONSE TO SEASONAL AND PANDEMIC

ROLE OF INTERNEURONS IN RESTING STATE FMRI CONNECTIVITY DURING NORMAL DEVELOPMENT AND AFTER PERINATAL BRAIN INJURY - DESPITE IMPROVEMENTS OF NEONATAL INTENSIVE CARE OVER RECENT DECADES, HYPOXIC-ISCHEMIC PERINATAL BRAIN INJURY REMAINS A MAJOR CAUSE OF NEURODEVELOPMENTAL IMPAIRMENT AMONG TERM AND PRETERM INFANT, INCLUDING MOTOR, BEHAVIORAL AND COGNITIVE DEFICITS. DIAGNOSIS OF COGNITIVE AND BEHAVIORAL ABNORMALITIES CANNOT BE ACCURATELY MADE UNTIL 2-3 YEARS OLD. CURRENT STATE OF THE ART PROVIDES NO OBJECTIVE FUNCTIONAL MEASURES OF BRAIN INJURY IN NEWBORNS THAT PREDICT LONG TERM COGNITIVE AND BEHAVIORAL DEFICITS. CLEARLY THERE IS A NEED FOR AN EARLY NON-INVASIVE MEASURE THAT CAN PROGNOSTICATE FOR COGNITIVE PROBLEMS IN LATER DEVELOPMENT AND PROVIDE AN OPPORTUNITY FOR EARLY INTERVENTION. AMONG FEW AVAILABLE MODALITIES TO ASSESS FUNCTIONAL BRAIN DEVELOPMENT IS RESTING STATE FUNCTIONAL MRI (RSFMRI). THIS MODALITY IS PARTICULARLY SUITED FOR NEONATAL AND INFANT STUDIES SINCE IT REQUIRES MINIMAL SUBJECT COOPERATION, EASY TO IMPLEMENT, SHORT IN DURATION, AND CAN BE DONE IN NATURAL SLEEP. HOWEVER, MECHANISM AND ORIGINS OF RSFMRI SIGNAL ARE POORLY UNDERSTOOD. EMERGING CELLULAR MECHANISMS OF MICROVASCULAR TONE REGULATION AND OUR PRELIMINARY OBSERVATIONS SUGGEST THAT ACTIVITY OF GABAERGIC INTERNEURONS, AND NOT PRIMARY NEURONS, MAY PLAY A SIGNIFICANT ROLE IN EARLY LOCAL RSFMRI CONNECTIVITY. DEVELOPMENTAL SHIFT TO HIGHER FREQUENCIES AND INCREASED AMPLITUDES OF RSFMRI BOLD OSCILLATIONS IN THIS RANGE COINCIDES WITH THE MATURATION OF INTERNEURONS IN SOMATOSENSORY CORTEXES IN EARLY PERINATAL PERIOD. WE HYPOTHESIZED THAT PROPERTIES OF RSFMRI SIGNAL IN THE HIGHER RANGE OF RSFMRI AND LOCAL RSFMRI CONNECTIVITY IS LARGELY DETERMINED BY ACTIVITY OF INTERNEURONS AND THUS REFLECT MATURATION PROGRESSION OF CORTICAL INTERNEURONS DURING NORMAL PERINATAL DEVELOPMENT AND AFTER INJURY. THE OVERALL GOALS OF THE PROPOSAL ARE TO EXPLORE CELLULAR MECHANISMS OF RSFMRI REGULATION, DISCOVER AND VALIDATE CELL SPECIFIC INFORMATION IN RSFMRI CONNECTIVITY THAT INFORMS US ABOUT THE STATE OF FUNCTIONAL MATURATION OF CORTICAL INTERNEURONS IN EARLY POSTNATAL PERIOD IN RABBIT. USING SIMULTANEOUS RECORDING OF NEURONAL ACTIVITY, LOCAL TISSUE OXYGEN FLUCTUATIONS DURING MRI ACQUISITION IN AIM 1 WE WILL CHARACTERIZE PHYSIOLOGICAL MECHANISMS MODULATING RESTING STATE FMRI SIGNAL IN RABBIT CORTEX DURING POSTNATAL DEVELOPMENT. ROLE OF INTERNEURONS WILL BE EXPLORED USING PHARMACOLOGICAL INTERVENTIONS TO SELECTIVELY BLOCK ACTIVITY OF INTERNEURONS AND AND/OR PYRAMIDAL NEURONS. SPECIFIC SIGNATURE OF INTERNEURON CONTRIBUTION TO RSFMRI SIGNAL AND LOCAL CONNECTIVITY BETWEEN NEIGHBORING VOXELS WILL BE DETERMINED DURING NORMAL POSTNATAL DEVELOPMENT AND APPLIED TO PREDICT INJURY TO INTERNEURONS AND COGNITIVE ABNORMALITIES IN AIM 2 IN A RABBIT MODEL OF ANTENATAL HYPOXIC ISCHEMIC INJURY.

SURVIVORS OF TORTURE, INTERNATIONAL WILL PROVIDE DIRECT SERVICES FOR THE REHABILITATION OF TORTURE SURVIVORS THROUGH PHYSICAL, PSYCHOLOGICAL, SOCIAL,SPIRITUAL AND LEGAL SUPPORT SERVICES.

NATIONAL LGBTQ INSTITUTE ON IPV

NON-CONTRAST MAGNETIC RESONANCE ANGIOGRAPHY OF PERIPHERAL VASCULAR DISEASE

PURPOSE: THE CONTINUUM OF CARE (COC) PROGRAM IS DESIGNED TO PROMOTE COMMUNITY-WIDE COMMITMENT TO THE GOAL OF ENDING HOMELESSNESS; PROVIDE FUNDING FOR EFFORTS BY NONPROFIT PROVIDERS, STATES, AND LOCAL GOVERNMENTS TO QUICKLY HOUSE HOMELESS INDIVIDUALS AND FAMILIES WHILE MINIMIZING THE TRAUMA AND DISLOCATION CAUSED TO HOMELESS INDIVIDUALS, FAMILIES, AND COMMUNITIES BY HOMELESSNESS; PROMOTE ACCESS TO AND EFFECTIVE UTILIZATION OF MAINSTREAM PROGRAMS BY HOMELESS INDIVIDUALS AND FAMILIES; AND OPTIMIZE SELF-SUFFICIENCY AMONG INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS. THE MOST RECENT COC AWARD ANNOUNCEMENT LISTING AWARDS BY STATE AND COC IS ACCESSIBLE AT HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/COC/AWARDS. SELECT THE LINK UNDER THE FUNDING AND AWARD INFORMATION SECTION FOR THE APPROPRIATE FISCAL YEAR.; ACTIVITIES TO BE PERFORMED: CONTINUUM OF CARE PROGRAM FUNDS MAY BE USED TO PAY FOR THE ELIGIBLE COSTS USED TO ESTABLISH AND OPERATE PROJECTS UNDER FIVE PROGRAM COMPONENTS: (1) PERMANENT HOUSING, WHICH INCLUDES PERMANENT SUPPORTIVE HOUSING FOR PERSONS WITH DISABILITIES, AND RAPID REHOUSING; (2) TRANSITIONAL HOUSING; (3) SUPPORTIVE SERVICES ONLY; (4) HOMELESS MANAGEMENT INFORMATION SYSTEMS (HMIS), AND (5) IN SOME CASES, HOMELESSNESS PREVENTION. THIRTEEN TYPES OF ASSISTANCE MAY BE PROVIDED THROUGH THE CONTINUUM OF CARE (COC) PROGRAM: (1) COC PLANNING ACTIVITIES/COSTS FOR DESIGNING AND CARRYING OUT A COLLABORATIVE PROCESS FOR THE DEVELOPMENT OF AN APPLICATION TO HUD; (2) UNITED FUNDING AGENCY (UFA) COSTS FOR FISCAL CONTROL AND ACCOUNTING NECESSARY TO ASSURE THE PROPER DISBURSAL OF, AND ACCOUNTING FOR, FEDERAL FUNDS AWARDED TO SUBRECIPIENTS UNDER THE CONTINUUM OF CARE PROGRAM, (3) ACQUISITION OF REAL PROPERTY (INCLUDING STRUCTURES) FOR USE IN THE PROVISION OF HOUSING OR SUPPORTIVE SERVICES; (4) REHABILITATION OF STRUCTURES TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (5) NEW CONSTRUCTION, INCLUDING THE BUILDING OF A NEW STRUCTURE OR BUILDING AN ADDITION TO AN EXISTING STRUCTURE FOR USE AS SUPPORTIVE HOUSING; (6) LEASING OF A STRUCTURE OR STRUCTURES, OR PORTIONS THEREOF, TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (7) RENTAL ASSISTANCE, WHICH MAY BE SHORT-TERM, MEDIUM-TERM, OR LONG-TERM, AS WELL AS TENANT-BASED, PROJECT-BASED, OR SPONSOR-BASED, FOR TRANSITIONAL OR PERMANENT HOUSING; (8) SUPPORTIVE SERVICES TO ASSIST PROGRAM PARTICIPANTS OBTAIN AND MAINTAIN HOUSING; (9) OPERATING COSTS OF SUPPORTIVE HOUSING; (10) COSTS OF IMPLEMENTING AND OPERATING HMIS; (11) PROJECT ADMINISTRATIVE COSTS; (12) RELOCATION COSTS; AND (13) INDIRECT COSTS IN ACCORDANCE WITH 2 CFR PARTS 200, AS APPLICABLE. IN ADDITION TO USING GRANT FUNDS FOR THE ELIGIBLE COSTS DESCRIBED ABOVE, RECIPIENTS AND SUBRECIPIENTS IN CONTINUUMS OF CARE DESIGNATED AS HIGH PERFORMING COMMUNITIES MAY ALSO USE GRANT FUNDS TO PROVIDE HOUSING RELOCATION AND STABILIZATION SERVICES AND SHORT- AND/OR MEDIUM-TERM RENTAL ASSISTANCE TO INDIVIDUALS AND FAMILIES AT RISK OF HOMELESSNESS AS SET FORTH IN 24 CFR 576.103 AND 24 CFR 576.104, IF NECESSARY TO PREVENT THE INDIVIDUAL OR FAMILY FROM BECOMING HOMELESS. LIMITATION ON USE OF FUNDS: NO ASSISTANCE PROVIDED UNDER PROGRAM (OR ANY STATE OR LOCAL GOVERNMENT FUNDS USED TO SUPPLEMENT THIS ASSISTANCE) MAY BE USED TO REPLACE STATE OR LOCAL FUNDS PREVIOUSLY USED, OR DESIGNATED FOR USE, TO ASSIST HOMELESS PERSONS OR PERSONS AT-RISK OF HOMELESSNESS.; EXPECTED OUTCOMES: DECREASE IN THE NUMBER INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS, MORE SPECIFICALLY USING PERFORMANCE INDICATORS SUCH AS THE LENGTH OF TIME HOMELESS, RETURNS TO HOMELESSNESS OVER TIME, AND EXITS TO PERMANENT HOUSING. COC PERFORMANCE PROFILE REPORTS CAN BE FOUND AT HTTPS://WWW.HUDEXCHANGE.INFO/PROGRAMS/COC/COC-PERFORMANCE-PROFILE-REPORTS/.; INTENDED BENEFICIARIES: INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

METHAMPHETAMINE AND OTHER SUBSTANCE ABUSE

A MOBILE APP TO REDUCE TREATMENT-RELATED FINANCIAL BURDEN FOR CANCER PATIENTS

DEVELOPMENT OF THE BREAKTHROUGH VORCAT TECHNOLOGY FOR CLOUD-BASED COMPLEX ENERGY SIMULATIONS

SPINAL SEROTONIN IN CEREBRAL PALSY

CONTINUUM OF CARE PROGRAM

PRE-PROCEDURAL EVALUATION OF HIGH-RISK PATIENTS USING NEXT-GENERATION RADIAL QISS

CONTINUUM OF CARE PROGRAM

PURPOSE: ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING/CONGRESSIONAL DIRECTED SPENDING AWARDS ARE AUTHORIZED UNDER THE CONSOLIDATED APPROPRIATIONS ACT, 2022 PUBLIC LAW 117-328 AND THE EXPLANATORY STATEMENT FOR DIVISION L OF THAT ACT. PROJECTS SELECTED FOR COMMUNITY PROJECT FUNDING/CONGRESSIONAL DIRECTED SPENDING ARE LISTED IN THE JOINT EXPLANATORY STATEMENT (JES) THAT ACCOMPANIES A SPECIFIC FISCAL YEAR’S APPROPRIATIONS ACT OR CONGRESSIONAL RECORD. THE JES LISTS PROJECT, RECIPIENT, STATE, AMOUNT AND CONGRESSIONAL SPONSOR.; ACTIVITIES TO BE PERFORMED: ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING AWARD PROJECTS INCLUDE A WIDE VARIETY OF ACTIVITIES THAT RESULT IN ECONOMIC DEVELOPMENT OR COMMUNITY DEVELOPMENT OUTCOMES. HUD WILL NOT KNOW THE FULL SCOPE OF THE PROJECT UNTIL THE RECIPIENT SUBMITS THE REQUIRED PROJECT NARRATIVE AND CONFIRMS ALIGNMENT WITH THE LANGUAGE AS PROVIDED IN THE CONGRESSIONAL RECORD. TO FIND THE DETAILS OF THE GRANT AWARD AS WRITTEN WITHIN THE CONGRESSIONAL RECORD USE THE FOLLOWING LINK AND PATH SELECTIONS TO GET TO THE DESCRIPTION OF THE ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING GRANTS HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/EDI-GRANTS, SELECT THE FISCAL YEAR OF INTEREST, SCROLL DOWN TO PROGRAM LAWS AND REGULATIONS, UNDER FISCAL YEAR 20XX CONSOLIDATED APPROPRIATIONS ACT, 20XX: CONGRESSIONAL RECORD (JOINT EXPLANATORY STATEMENT).; EXPECTED OUTCOMES: COMPLETION OF THE PROJECT AS DESCRIBED IN THE JOINT EXPLANATORY STATEMENT (JES) PROJECT DESCRIPTION AND SUBSEQUENT APPROVED PROJECT NARRATIVE.; INTENDED BENEFICIARIES: THE PROJECT BENEFICIARIES ARE THE INDIVIDUALS AND/OR ORGANIZATIONS THAT ARE AWARDED GRANT FUNDS OR SERVED BY THE ENTITIES THAT ARE AWARDED GRANT FUNDS AS IDENTIFIED IN THE JES RECIPIENT OR PROJECT DESCRIPTION SECTIONS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

AWARD PURPOSE.WORC PURPOSE: IN ALIGNMENT WITH THE JUSTICE40 INITIATIVE, THE PURPOSE OF THE WORC INITIATIVE GRANTS IS TO CREATE ECONOMIC MOBILITY, ADDRESS HISTORIC INEQUITIES FOR MARGINALIZED COMMUNITIES OF COLOR, RURAL AREAS, AND OTHER UNDERSERVED AND UNDERREPRESENTED COMMUNITIES, AND PRODUCE HIGH-QUALITY EMPLOYMENT OUTCOMES FOR WORKERS WHO LIVE OR WORK IN THE APPALACHIAN, DELTA, AND NORTHERN BORDER REGIONS, ENABLING THEM TO REMAIN AND THRIVE IN THESE COMMUNITIES. PROJECT TITLE: CONNECTING RURAL, MARGINALIZED RESIDENTS OF SOUTHEAST OHIO TO EMPLOYERS IN APPALACHIA IN ALIGNMENT WITH THE GOOD JOBS PRINCIPLESGRANTEE REGION: ARCDELIVERABLES EXPECTED OUTCOMES.TOTAL PARTICIPANTS: 30PARTICIPANTS OBTAINING NEW OR ENHANCED EMPLOYMENT: 30INTENDED BENEFICIARIES.TARGET POPULATION: DISLOCATED WORKERS, INCUMBENT WORKERS, AND NEW WORKFORCE ENTRANTSAREAS TO BE SERVED: ATHENS, GALLIA, HOCKING, JACKSON, LAWRENCE, MEIGS, MORGAN, PERRY, AND VINTON COUNTIES IN SOUTHEASTERN OHIOACTIVITIES TO BE PERFORMED.SUMMARY OF PROJECT: SAOP AIMS TO DISPLAY A COMMITMENT TO THE CORE PRINCIPLES BY INCREASING THE NUMBER OF SKILLED WORKERS IN APPALACHIAN OHIO THROUGH AN EXPANSION OF A CURRENT AND SUCCESSFUL WORKFORCE DEVELOPMENT PROGRAM AND A NEW PARTNERSHIP WITH AN EXTENSION OF AN ESTABLISHED APPAREL COMPANY IN A GROWING INDUSTRY AND RESHORING EFFORT. THE JOBS CREATED AND MAINTAINED WITH WORC FUNDING WILL ENSURE LIVING WAGES, HEALTHY WORKING CONDITIONS, AND SKILL CAREER ADVANCEMENT. ADDITIONALLY, A MINIMUM OF 15 EMPLOYERS IN APPALACHIAN OHIO WILL BE PROVIDED WITH AN OPPORTUNITY INVOLVING EDUCATION ON THE GOOD JOBS PRINCIPLES FROM THE WORC INITIATIVE TO PROVIDE A WIDESPREAD ATTEMPT TO INCREASE THE AVAILABILITY OF GOOD JOBS IN THE REGION AND BE A CATALYST FOR ECONOMIC TRANSFORMATION.SUBRECIPIENT ACTIVITIES.THE RECIPIENT DOES NOT INTEND TO SUBAWARD FUNDS.

TAS::89 0321::TAS ADVANCED INTEGRATION OF POWER TAKE-OFF IN VIVACE

DETECTION, EDUCATION, RESEARCH AND DECOLONIZATION WITHOUT ISOLATION IN LONG-TERM

BEHAVIORAL HEALTHCARE PARTNERS OF CENTRAL OHIO, INC. CERTIFIED COMMUNITY BEHAVIORAL HEALTH CLINIC EXPANSION - BEHAVIORAL HEALTHCARE PARTNERS OF CENTRAL OHIO - CERTIFIED COMMUNITY BEHAVIORAL HEALTH EXPANSION PROJECT BEHAVIORAL HEALTHCARE PARTNERS OF CENTRAL OHIO, INC.’S (BHP) CERTIFIED COMMUNITY BEHAVIORAL HEALTH CLINIC EXPANSION PROJECT WILL SERVE ADULTS, ADOLESCENTS, AND CHILDREN WITH THE MOST SERIOUS AND COMPLEX MENTAL AND SUBSTANCE USE DISORDERS (SUD) USING A COMPREHENSIVE COLLECTION OF SERVICES THAT CREATES ACCESS TO CARE, STABILIZATION OF INDIVIDUALS IN CRISIS, AND NEEDED TREATMENT AND RECOVERY SUPPORT SERVICES. DURING THE TWO YEAR PROJECT BEHAVIORAL HEALTHCARE PARTNERS PLANS TO SERVE 250 NEW CLIENTS DURING YEAR 1 (AUGUST 30, 2020 – AUGUST 29, 2021) AND 250 NEW CLIENTS DURING YEAR 2 (AUGUST 30, 2021 – AUGUST 29, 2022) FOR A TOTAL OF 500 CLIENTS DURING THE PROJECT PERIOD. BHP’S CCBHC EXPANSION PROJECT WILL SERVE THE CENTRAL OHIO REGION WITH A FOCUS IN LICKING AND KNOX COUNTIES. THESE AREAS ARE LOCATED TO THE EAST/NORTHEAST OF THE STATE CAPITAL OF COLUMBUS. ACCORDING TO THE US CENSUS BUREAU, LICKING COUNTY IS A SUBURBAN-RURAL AREA WITH A POPULATION OF 172,293 AND KNOX COUNTY IS IDENTIFIED AS A RURAL COUNTY WITH A POPULATION OF 61,215. ALTHOUGH, LICKING AND KNOX COUNTIES ARE NOT DESIGNATED AS APPALACHIAN BY THE APPALACHIAN REGIONAL COMMISSION, BOTH COUNTIES ARE BORDERED BY APPALACHIAN COUNTIES AND MANY OF THE CULTURAL NORMS ASSOCIATED WITH APPALACHIA ARE PREVALENT IN OUR CATCHMENT AREA. THE MENTAL HEALTH AND RECOVERY BOARD FOR LICKING AND KNOX COUNTY’S (MHR) 2017 COMMUNITY PLAN SHOWS EVIDENCE OF THE INCREASED NEED FOR BEHAVIORAL HEALTH SERVICES. THE REPORT STATES THAT CALLS TO TREATMENT PROVIDERS FOR SERVICES FROM NEW CLIENTS OR POTENTIAL CLIENTS HAD INCREASED BY 41% IN COMPARING FISCAL YEARS 2012 AND 2013 TO FISCAL YEARS 2010 AND 2011. OVER A THREE-YEAR PERIOD (2013 – 2015) THE 211 CRISIS/HOTLINE & INFORMATION AND REFERRAL LINE LISTED REQUESTS REGARDING MENTAL HEALTH AND ADDICTION CONSISTENTLY AS THE TOP REQUEST FOR INFORMATION. (HTTPS://MHA.OHIO.GOV/PORTALS/0/ASSETS/SCHOOLSANDCOMMUNITIES/COMMUNITYANDHOUSING/COMMUNITY-PLANNING/2017/KNOX-LICKING.PDF?VER=2018-12-17-090048-343) OHIO HAS BEEN HIT HARD BY THE CURRENT OPIOID EPIDEMIC. ACCORDING TO THE CENTER FOR DISEASE CONTROL, OHIO RANKS AS THE SECOND HIGHEST STATE IN THE COUNTRY FOR OPIOID RELATED DEATHS (4,329 IN 2016) OR AT A RATE OF 39.2 DEATHS PER 100,000 PERSONS, COMPARED TO THE AVERAGE NATIONAL RATE OF 14.6 DEATHS PER 100,000 PERSONS. (HTTPS://WWW.DRUGABUSE.GOV/OPIOID-SUMMARIES-BY-STATE/OHIO-OPIOID-SUMMARY) THE MHR 2017 COMMUNITY PLAN STATES AN ESTIMATED 6.5% OF RESIDENTS IN LICKING AND KNOX COUNTIES, AGES 12+, ARE SUBSTANCE DEPENDENT AND IN NEED OF SUBSTANCE ABUSE TREATMENT SERVICES. THE PLAN ALSO ESTIMATES THAT APPROXIMATELY 14% OF THE ADULT RESIDENTS IN THE TWO COUNTIES WOULD BENEFIT FROM MENTAL HEALTH TREATMENT SERVICES, AND APPROXIMATELY 3% OF RESIDENTS HAVE EXPERIENCED A SEVERE MENTAL ILLNESS.

INSTITUT PASTEUR DE COTE DIVOIRE APPLICATION TO CDC RFA-GH15-1627 BUILDING AND STRENGTHENING PUBLIC HEALTH LABORATORY SYSTEMS, CAPACITY AND SECURITY

PREVENTION OF PRETERM BIRTH USING THE COLLECTIN SURFACTANT PROTEIN A (SP-A)

CONTINUUM OF CARE PROGRAM

CONTINUUM OF CARE PROGRAM

AP-1 FACTORS IN THE PATHOGENESIS AND PROGRESSION OF BENIGN PROSTATIC HYPERPLASIA

2/2 TARGETED SEQUENCING AND FUNCTIONAL EVALUATION OF MUTATIONS IN SCHIZOPHRENIA

CONTINUUM OF CARE PROGRAM

HUMAN IPSC NEURAL SPHEROIDS TO SCREEN FOR COMPOUNDS THAT BLOCK TAU PROPAGATION - RESEARCH & RELATED OTHER PROJECT INFORMATION NOVORON BIOSCIENCE, INC. 7. PROJECT SUMMARY APPROXIMATELY 6.9 MILLION PEOPLE AGED 65 AND OLDER IN THE UNITED STATES HAVE ALZHEIMER’S DEMENTIA (AD).1,2 AD AND OTHER DEMENTIAS ARE A MAJOR ECONOMIC BURDEN EXPECTED TO COST $360 B IN 2024, OF WHICH $231 B WILL BE FUNDED THROUGH MEDICARE AND MEDICAID.3 THERE IS AN URGENT NEED TO IDENTIFY AND DEVELOP DISEASE-MODIFYING THERAPEUTICS AS CURRENT THERAPIES ONLY ADD 0.65 QUALITY-ADJUSTED LIFE YEARS AND COST $130,000 PER YEAR.4,5 TAUOPATHIES, INCLUDING AD, EXHIBIT PRION-LIKE NEURON-TO-NEURON TRANSSYNAPTIC PROPAGATION OF TAU.6 HERE, WE PROPOSE A PLATFORM-BASED STRATEGY TO EVALUATE NOVEL THERAPIES DESIGNED TO INHIBIT THE PROPAGATION AND AGGREGATION OF PATHOLOGICAL TAU. AS PART OF THIS PLATFORM, WE WILL USE LRP1 (AN ESTABLISHED MODEL KNOWN TO INFLUENCE TAU PROPAGATION) WT AND KO HUMAN INDUCED PLURIPOTENT STEM CELL (HIPSCS) DERIVED NEURAL ORGANOIDS TO CONFIRM THAT OUR SYSTEM ACCURATELY DETECTS CHANGES IN TAU PROPAGATION. THIS ROBUST, MULTI-FACETED PLATFORM WILL ENABLE THE IDENTIFICATION AND VALIDATION OF CANDIDATES THAT DISRUPT TAU PATHOLOGY, PROVIDING A PATH TOWARD NEW TREATMENTS FOR AD AND OTHER TAUOPATHIES. OUR TEAM AND OTHERS HAVE SHOWN THAT ORGANOIDS GENERATED FROM HIPSCS SERVE AS A SCALED-DOWN AND THREE- DIMENSIONAL MODEL OF THE HUMAN BRAIN, MIMICKING VARIOUS DEVELOPMENTAL FEATURES AT THE CELLULAR AND MOLECULAR LEVELS. UNLIKE ANIMAL MODELS, WHICH DO NOT ALWAYS TRANSLATE TO HUMAN UTILITY, OR OTHER IN VITRO MODELS, WHICH CANNOT CAPTURE THE COMPLEXITY OF HUMAN TISSUES, ORGANOIDS RECAPITULATE ASPECTS OF IN VIVO BRAIN DEVELOPMENT AND FUNCTION IN A DISH. ORGANOIDS ARE RECOGNIZED FOR THEIR USEFULNESS AS A TRANSLATIONALLY VALID ORGAN-LEVEL PLATFORM IN THE DRUG DISCOVERY SPACE FOR COLON CANCER, CYSTIC FIBROSIS, AND PRECISION THERAPY. CORTICAL ORGANOIDS HAVE FURTHER PROVEN TO BE INFORMATIVE MODELS OF HUMAN BRAIN DEVELOPMENT, TISSUE ORGANIZATION AND CELL-CELL INTERACTIONS, AND MATURATION, SUGGESTING A LIKELY UTILITY IN THERAPEUTIC ADVANCEMENT. CORTICAL ORGANOIDS RETAIN PROPERTIES OF A NEURAL ORGAN TO A LARGE DEGREE, INCLUDING INTEGRATION OF SUPPORTING CELLS, CYTOSKELETAL STRUCTURING, CELLULAR ORGANIZATION INTO PARTICULAR REGIONS, AND IN SOME CASES, IN VIVO-LIKE SPONTANEOUS NETWORK ACTIVITY. OUR TEAM RECENTLY USED RETT SYNDROME ORGANOIDS TO IDENTIFY DONEPEZIL (APPROVED FOR AD AS ARICEPT) THAT IS NOW ENTERING A DOD-FUNDED PHASE II CLINICAL TRIAL. WE WILL CREATE LRP1 WT AND KO ORGANOIDS TO OPTIMIZE AND VALIDATE THE UTILITY OF THE ORGANOIDS IN SCREENING WITH CONTROL COMPOUNDS AND THE ABILITY OF THE EXPERIMENTAL SMALL MOLECULES TO MODULATE TAU PROPAGATION. THIS PROJECT BRINGS TOGETHER THE EXPERTISE OF NOVORON BIOSCIENCE, BRAINSTORM THERAPEUTICS, AND DEFINED BIOSCIENCE TO DEVELOP HUMAN-RELEVANT BRAIN MODELS FOR DRUG DISCOVERY. BY EMPLOYING ADVANCED HIPSC-DERIVED CORTICAL BRAIN ORGANOID TECHNOLOGIES, WE AIM TO ESTABLISH A SCALABLE, HIGH-THROUGHPUT SCREENING PLATFORM TO IDENTIFY SMALL MOLECULES THAT DISRUPT TAU-LRP1 INTERACTIONS. THE PROJECT ADDRESSES CRITICAL UNMET NEEDS IN ALZHEIMER’S DRUG DEVELOPMENT AND WILL GENERATE NEW INSIGHTS INTO TAU PATHOLOGY MECHANISMS.

STTR PHASE II: INNOVATIVE DISPERSION TECHNOLOGY FOR THE SUSTAINABLE REPURPOSING OF OFF-SPEC AND RECYCLED CARBON FIBER INTO LOW-COST, DEFECT-FREE, NONWOVEN FABRICS -THE BROADER/COMMERCIAL IMPACT OF THIS SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PHASE II PROJECT IS THE DEVELOPMENT OF AN INNOVATIVE MIXER FOR THE DISPERSION OF CARBON FIBER IN THE NONWOVEN METHOD KNOWN AS WET LAID. THE PATENTED TECHNIQUE IS USED TO FABRICATE MATS FOR USE IN THE PRODUCTION OF ADVANCED COMPOSITE MATERIALS, LIGHTWEIGHT MATERIALS CHARACTERIZED BY HIGH SPECIFIC STRENGTH AND STIFFNESS. IT HAS BEEN PREVIOUSLY SHOWN THAT THE TECHNIQUE COULD BE USED TO PRODUCE HIGH-PERFORMING NONWOVEN FABRICS IN A COST-EFFECTIVE, SUSTAINABLE, AND HIGHLY REPRODUCIBLE MANNER BY INCORPORATING MATERIAL THAT IS GENERALLY DISCARDED, INCLUDING OFF-SPEC CARBON FIBERS AND RECYCLED CARBON FIBERS. THE COMPANY NOW PLANS TO USE THIS INNOVATIVE PROCESS WITH AN OFF-SPEC CARBON-HEMP, POLYPROPYLENE BLEND TO DEVELOP A SUSTAINABLE AND COST-EFFICIENT PRODUCT LINE SUITABLE FOR AN AUTOMOTIVE USE CASE. THE WORK WILL PROVIDE VALUABLE INSIGHT INTO HYBRID REINFORCEMENT OF COMPOSITES, A LARGELY UNSTUDIED AREA. IT WILL ALSO PROVIDE A MODEL FOR PRODUCTION OF HYBRID-REINFORCED COMPOSITE PRODUCTS AND A COMPREHENSIVE ASSESSMENT OF PRODUCTS DERIVED FROM OFF-SPEC CARBON FIBER AND RECYCLED CARBON FIBER. THE DEVELOPMENT OF THIS COST-EFFICIENT TECHNIQUE TO PRODUCE CARBON FIBER ADVANCED COMPOSITES WILL CREATE OPPORTUNITIES FOR SEVERAL INDUSTRIES TO INCORPORATE THESE HIGH-PERFORMANCE MATERIALS INTO A VARIETY OF PRODUCTS AND APPLICATIONS. THIS SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PHASE II PROJECT WILL DEVELOP A NOVEL METHOD WHERE OFF-SPEC AND RECYCLED CARBON FIBER CAN BE COST-EFFICIENTLY PROCESSED INTO HIGH-VALUE MATERIALS. THIS TECHNIQUE OFFERS A WAY TO PRODUCE NONWOVEN MATS WITH FIBER LENGTH RETENTION AND TAILORED FIBER ORIENTATION. THE SYSTEM CAN PRODUCE CARBON FIBER MATS AT VARIOUS AREA DENSITIES AND IS COMPATIBLE WITH PRODUCTION OF HYBRID FIBER TEXTILES SUCH AS MIXTURES OF CARBON FIBER/THERMOPLASTIC FIBERS (E.G., POLYPROPYLENE FIBERS), NATURAL FIBERS, AND OTHER SYNTHETICS SUCH AS GLASS, BASALT, AND KEVLAR. THE PROJECT WILL FOCUS ON PRODUCING AND EVALUATING ADVANCED COMPOSITE MATERIALS FOR AN AUTOMOTIVE USE CASE. THIS ANALYSIS WILL PROVIDE CRITICAL INSIGHT INTO THE MECHANICAL AND COMMERCIALLY-RELEVANT PROPERTIES OF COMPOSITES GENERATED THROUGH HYBRID REINFORCEMENT. THE PROJECT ALSO AIMS TO DEMONSTRATE CONSISTENCY ACROSS PRODUCTION BATCHES AT LARGER SCALES BY EVALUATING PRODUCED MATS AND MEASURING KEY PERFORMANCE INDICATORS IN A HIGH-EFFICIENCY FABRIC PRODUCTION SCENARIO. THIS WORK WILL HELP ILLUMINATE KEY CONSIDERATIONS FOR THE PRODUCTION OF HYBRID REINFORCED COMPOSITES AND INFORM FUTURE PRODUCT DESIGN. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

CONTINUUM OF CARE PROGRAM

PURPOSE OF PROJECT: FAMILY ENDEAVORS INC., DBA ENDEAVORS, PROPOSES TO EXTEND HVRP SERVICES TO HOMELESS VETERANS (CATEGORY 1) WHO RESIDE IN THE ESCAMBIA, COUNTY. THE PURPOSE OF OUR PROJECT IS TO HELP VETERANS ACHIEVE ECONOMIC PROSPERITY AND ADDRESS HISTORICAL INEQUITIES. ENDEAVORS GOAL FOR THE HVRP PROGRAM IS TO FACILITATE HIGH-QUALITY CAREER OUTCOMES FOR VETERAN EXPERIENCING HOMELESSNESS. OUR PRIMARY STRATEGIES ARE 1) PREPARE AND CONNECT PARTICIPANTS TO JOB TRAINING AND COMPETITIVE EMPLOYMENT OPPORTUNITIES 2) USE MULTI-DISCIPLINARY APPROACHES TO IDENTIFY AND ADDRESS BARRIERS TO EMPLOYMENT AND JOB RETENTION, SUCH AS PREVIOUS ICACERATION AND SUBSTANCE USE DISORDERS, AND 3) CREATE LINKAGE TO HOUSING. ENDEAVORS WILL COORDINATE JOB PLACEMENT ASSISTANCE WITH THE AMERICAN JOB CENTERS IN ARIZONA AND OTHER MEMBERS OF THE WORKFORCE DEVELOPMENT SYSTEM. ASSISTING VETERANS IN ESTABLISHING AND MAINTAINING A WORKING LIFE REQUIRES A BASIC UNDERSTANDING OF MILITARY CULTURE POSITION. WE HAVE A COMMITMENT TO ARIZONA S VETERANS TO IMPROVE THEIR QUALITY OF LIFE WITH FAIR AND DIGNIFIED TREATMENT. ACTIVITIES FUNDED BY GRANT: CASE MANAGEMENT SERVICES WORKSHOPS (VIRTUAL, HYBRID, AND IN-PERSON) ON-THE-JOB TRAINING, CAREER COUNSELING, CHILD CARE, TRANSPORTATION, WORK CLOTHES, RESUME BUILDING, FINANCIAL ASSISTANCE UPON ELIGIBILITY, JOB PLACEMENT THROUGH AMERICAN JOB CENTERS AND OTHER WORKFORCE ORGANIZATION, AND SUPPORT SERVICES. INTENDED BENEFICIARIES OF THE PROJECT: WE WILL BE IMPACTING 58 VETERANS PER YEAR IN PENSACOLA, FLORIDA. OUTCOMES OF THE PROJECT: ENDEAVORS WILL PROJECT TO IMPACT 58 HOMELESS VETERANS IN THE PERIOD OF PERFORMANCE. WE EXPECT TO HAVE AN OVERALL PLACEMENT RATE OF 68%.KEY PARTNERSHIPS: ESCAMBIA COUNTY VETERAN SERVICES, PENSACOLA VETERAN AFFAIRS CLINIC, AND PENSACOLA VETERANS CENTER VETERAN AFFAIRS SUBRECIPIENT ACTIVITIES: N ARECIPIENT OF OTHER FUNDING: N A

AWARD PURPOSE HVRP IS AN EMPLOYMENT-FOCUSED COMPETITIVE GRANT PROGRAM THAT FOCUSES EXCLUSIVELY ON OBTAINING COMPETITIVE EMPLOYMENT FOR VETERANS EXPERIENCING OR AT-RISK OF HOMELESSNESS. ACTIVITIES PERFORMED EMPLOYMENT SERVICES, JOB TRAINING DELIVERABLES HVRP GRANT RECIPIENTS WILL PROVIDE EMPLOYMENT SERVICES AND JOB TRAINING TO VETERANS EXPERIENCING HOMELESSNESS WHICH WILL RESULT IN THE VETERANS EARNING INCOME AND LONG TERM JOB STABILITY AS EVIDENCED BY JOB PLACEMENT RATES, AND EARNINGS INCOME AFTER EXITING THE PROGRAM. INTENDED BENEFICIARY VETERANS AT RISK OF OR EXPERIENCING HOMELESSNESS. GRANT RECIPIENTS MAY ALSO CHOOSE TO FOCUS SERVICES TO VETERANS TRANSITIONING FROM INCARCERATION, HOMELESS FEMALE VETERANS AND/OR HOMELESS VETERANS WITH CHILDREN. SUBRECIPIENT ACTIVITIES RECIPIENTS GENERALLY DO NOT SUB-AWARD FUNDS.

VALIDATING MOUSE MODELS OF PROSTATIC HYPERPLASIA - OVERALL: SUMMARY THIS P20 FORWARD CENTER WILL SUPPORT A PROJECT CONCEIVED AND EXECUTED BY THREE EARLY STAGE INVESTIGATORS (ESIS) TO ADDRESS A PROBLEM THAT IS IMPORTANT TO THE FIELD OF BENIGN PROSTATE RESEARCH AND TO OTHER FIELDS MORE BROADLY: THE RELEVANCE OF SPECIFIC GENETICALLY ENGINEERED MOUSE MODELS TO HUMAN DISEASE. THE NEED FOR ANIMAL MODELS IN BIOMEDICAL RESEARCH AND THE UTILITY OF MICE, SPECIFICALLY, IS WELL RECOGNIZED AND ACCEPTED. A NUMBER OF MOUSE MODELS THAT PURPORT TO REPRESENT THIS DISEASE HAVE BEEN GENERATED. IT IS WELL RECOGNIZED IN THE FIELD THAT NONE OF THESE IS A GOOD OVERALL REPRESENTATION OF THE HUMAN CONDITION. AS SUCH, CRITICISM OF MODELS IS A COMMON ISSUE IN GRANT AND PAPER REVIEW. THIS IS A PROBLEM FOR ALL INVESTIGATORS IN THE FIELD AND CAN BE PARTICULARLY DAMAGING TO ESIS WHO DO NOT HAVE RESOURCES TO GENERATE DATA FROM MULTIPLE LINES. THE CENTER WILL BRING TOGETHER TWO BIOLOGISTS (DRS. POPOVICS AND VICKMAN) WITH COMPLEMENTART SKILL SETS AND AN INTEREST IN BPH, , CONTRIBUTING EXPERTISE IN MOUSE MODELS AND INFLAMMATION, WITH A BIOINFORMATICIAN (DR. LANMAN) TO DEVELOP NEW APPROACHES TO CORRELATE TRANSCRIPTOMIC DATA FROM MICE WITH EXISTING HUMAN BPH DATASETS TO ESTABLISH A REFERENCE DTABASE ENCOMPASSING SIMILARITIES AND DIFFERENCES BETWEEN INDIVIDUAL MOUSE MODELS AND SALIENT ASPECTS OF HUMAN DISEASES. SUCCESSFUL DEVELOPMENT OF THESE METHODS WILL ALLOW BROAD APPLICATION OF THE APPROACH ACROSS A RANGE OF DISEASES WHERE SUCH PROBLEMS EXIST. THE PROJECT WILL ESTABLISH STANDARDS AND BENCHMARKS FOR COMPARING MOUSE MODELS TO HUMAN BPH AND IDENTIFYING COMMONALITIES AND DISPARITIES BETWEEN THE TWO. THIS WILL FACILITATE THE SELECTION OF THE BEST MODELS AND WILL ENCOURAGE SIMILAR CHARACTERIZATION AND COMPARISON OF OTHER MODELS IN THE FIELD. THE DATA WILL BE MADE AVAILABLE TO THE SCIENTIFIC COMMUNITY, AS A COLLECTION IN THE CELLXGENE PORTAL AND AS AN RSHINY APPLICATION. CONSISTENT WITH THE STATED GOALS OF THE RFA THE ADMINISTRATIVE CORE AND ITS DIRECTOR (THE PI, DR. HAYWARD) WILL SUPPORT THE PROJECT AND SPECIFICALLY WILL PROVIDE ACCESS TO RESOURCES AND EXPERTISE TO ASSIST THE THREE ESIS IN THE DEVELOPMENT OF NEW FUNDING PROPOSALS DERIVATIVE FROM THE DATA GENERATED HERE. THE ADMINISTRATIVE CORE WILL ALSO OVERSEE THE FISCAL AND REGULATORY ASPECTS OF THE CENTER AND WILL PROVIDE MECHANISMS FOR REGULAR CONTACTS BETWEEN THE PROJECT INVESTIGATORS AND THE BROADER RESEARCH COMMUNITY, IN PARTICULAR WITH PAST AND PRESENT CAIRIBU MEMBERS, FOSTERING OPPORTUNITIES TO PRESENT DATA AND FURTHERING CAREER OPPORTUNITIES. THE ADMINSTRATIVE CORE WILL ALSO COORDINATE WITH EXPERTS IN THE FIELD TO SUPPORT THE DEVELOPMENT AND SUBMISSION OF NEW GRANT PROPOSALS FROM THE ESIS. THE IMMEDIATE GOAL OF THIS CENTER IS TO SUPPORT THE DEVELOPMENT OF DATA THAT WILL CONTRIBUTE TO THE CAREER DEVELOPMENT AND FUNDING SUCCESS OF THREE EARLY STAGE INVESTIGATORS IN THE FIELD OF BENIGN UROLOGIC RESEARCH, BRING NEW IDEAS AND RETAIN EXPERTISE IN THE FIELD. THE LONG-TERM GOAL IS FOR THE ESIS TO ACHIEVE SIGNIFICANT INDEPENDENT CAREERS.

OVW FY 06 RURAL DOMESTIC VIOLENCE AND CHILD VICTIMIZATION ENFORCEMENT GRANTS

SERVICES FOR SURVIVORS OF TORTURE PROGRAM

TARGETING RACIAL DISPARITIES IN STROMAL DGAT TO SUPPRESS AGGRESSIVE PROSTATE CANCER

SEE NOTICE OF AWARD, ATTACHMENT 1 - TERMS AND CONDITIONS, ATTACHMENT D-STATEMENT OF WORK, ABSTRACT

PURPOSE: THE CONTINUUM OF CARE (COC) PROGRAM IS DESIGNED TO PROMOTE COMMUNITY-WIDE COMMITMENT TO THE GOAL OF ENDING HOMELESSNESS; PROVIDE FUNDING FOR EFFORTS BY NONPROFIT PROVIDERS, STATES, AND LOCAL GOVERNMENTS TO QUICKLY HOUSE HOMELESS INDIVIDUALS AND FAMILIES WHILE MINIMIZING THE TRAUMA AND DISLOCATION CAUSED TO HOMELESS INDIVIDUALS, FAMILIES, AND COMMUNITIES BY HOMELESSNESS; PROMOTE ACCESS TO AND EFFECTIVE UTILIZATION OF MAINSTREAM PROGRAMS BY HOMELESS INDIVIDUALS AND FAMILIES; AND OPTIMIZE SELF-SUFFICIENCY AMONG INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS. THE MOST RECENT COC AWARD ANNOUNCEMENT LISTING AWARDS BY STATE AND COC IS ACCESSIBLE AT HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/COC/AWARDS. SELECT THE LINK UNDER THE FUNDING AND AWARD INFORMATION SECTION FOR THE APPROPRIATE FISCAL YEAR.; ACTIVITIES TO BE PERFORMED: CONTINUUM OF CARE PROGRAM FUNDS MAY BE USED TO PAY FOR THE ELIGIBLE COSTS USED TO ESTABLISH AND OPERATE PROJECTS UNDER FIVE PROGRAM COMPONENTS: (1) PERMANENT HOUSING, WHICH INCLUDES PERMANENT SUPPORTIVE HOUSING FOR PERSONS WITH DISABILITIES, AND RAPID REHOUSING; (2) TRANSITIONAL HOUSING; (3) SUPPORTIVE SERVICES ONLY; (4) HOMELESS MANAGEMENT INFORMATION SYSTEMS (HMIS), AND (5) IN SOME CASES, HOMELESSNESS PREVENTION. THIRTEEN TYPES OF ASSISTANCE MAY BE PROVIDED THROUGH THE CONTINUUM OF CARE (COC) PROGRAM: (1) COC PLANNING ACTIVITIES/COSTS FOR DESIGNING AND CARRYING OUT A COLLABORATIVE PROCESS FOR THE DEVELOPMENT OF AN APPLICATION TO HUD; (2) UNITED FUNDING AGENCY (UFA) COSTS FOR FISCAL CONTROL AND ACCOUNTING NECESSARY TO ASSURE THE PROPER DISBURSAL OF, AND ACCOUNTING FOR, FEDERAL FUNDS AWARDED TO SUBRECIPIENTS UNDER THE CONTINUUM OF CARE PROGRAM, (3) ACQUISITION OF REAL PROPERTY (INCLUDING STRUCTURES) FOR USE IN THE PROVISION OF HOUSING OR SUPPORTIVE SERVICES; (4) REHABILITATION OF STRUCTURES TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (5) NEW CONSTRUCTION, INCLUDING THE BUILDING OF A NEW STRUCTURE OR BUILDING AN ADDITION TO AN EXISTING STRUCTURE FOR USE AS SUPPORTIVE HOUSING; (6) LEASING OF A STRUCTURE OR STRUCTURES, OR PORTIONS THEREOF, TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (7) RENTAL ASSISTANCE, WHICH MAY BE SHORT-TERM, MEDIUM-TERM, OR LONG-TERM, AS WELL AS TENANT-BASED, PROJECT-BASED, OR SPONSOR-BASED, FOR TRANSITIONAL OR PERMANENT HOUSING; (8) SUPPORTIVE SERVICES TO ASSIST PROGRAM PARTICIPANTS OBTAIN AND MAINTAIN HOUSING; (9) OPERATING COSTS OF SUPPORTIVE HOUSING; (10) COSTS OF IMPLEMENTING AND OPERATING HMIS; (11) PROJECT ADMINISTRATIVE COSTS; (12) RELOCATION COSTS; AND (13) INDIRECT COSTS IN ACCORDANCE WITH 2 CFR PARTS 200, AS APPLICABLE. IN ADDITION TO USING GRANT FUNDS FOR THE ELIGIBLE COSTS DESCRIBED ABOVE, RECIPIENTS AND SUBRECIPIENTS IN CONTINUUMS OF CARE DESIGNATED AS HIGH PERFORMING COMMUNITIES MAY ALSO USE GRANT FUNDS TO PROVIDE HOUSING RELOCATION AND STABILIZATION SERVICES AND SHORT- AND/OR MEDIUM-TERM RENTAL ASSISTANCE TO INDIVIDUALS AND FAMILIES AT RISK OF HOMELESSNESS AS SET FORTH IN 24 CFR 576.103 AND 24 CFR 576.104, IF NECESSARY TO PREVENT THE INDIVIDUAL OR FAMILY FROM BECOMING HOMELESS. LIMITATION ON USE OF FUNDS: NO ASSISTANCE PROVIDED UNDER PROGRAM (OR ANY STATE OR LOCAL GOVERNMENT FUNDS USED TO SUPPLEMENT THIS ASSISTANCE) MAY BE USED TO REPLACE STATE OR LOCAL FUNDS PREVIOUSLY USED, OR DESIGNATED FOR USE, TO ASSIST HOMELESS PERSONS OR PERSONS AT-RISK OF HOMELESSNESS.; EXPECTED OUTCOMES: DECREASE IN THE NUMBER INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS, MORE SPECIFICALLY USING PERFORMANCE INDICATORS SUCH AS THE LENGTH OF TIME HOMELESS, RETURNS TO HOMELESSNESS OVER TIME, AND EXITS TO PERMANENT HOUSING. COC PERFORMANCE PROFILE REPORTS CAN BE FOUND AT HTTPS://WWW.HUDEXCHANGE.INFO/PROGRAMS/COC/COC-PERFORMANCE-PROFILE-REPORTS/.; INTENDED BENEFICIARIES: INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

DEVELOPING A NOVEL VESICO-AMNIOTIC SHUNT TO TREAT FETAL LOWER URINARY TRACT OBSTRUCTION - PROJECT SUMMARY FETAL LOWER URINARY TRACT OBSTRUCTION (LUTO) IS A SEVERE BIRTH DEFECT THAT RESULTS IN DAMAGE OR MALFORMATION OF THE BLADDER, KIDNEYS, AND LUNGS. LUTO IS ASSOCIATED WITH AN UP TO 80% MORTALITY RISK, AND SURVIVORS CONTINUE TO SUFFER LIFE-LONG COMPLICATIONS ASSOCIATED WITH THEIR KIDNEYS AND URINARY AND PULMONARY SYSTEMS. LUTO CAN BE TREATED BY PERFORMING FETAL SURGERY (USUALLY IN THE SECOND OR THIRD TRIMESTER) TO IMPLANT A VESICOAMNIOTIC SHUNT (VAS). THIS CREATES AN ALTERNATE CHANNEL BETWEEN THE BLADDER AND AMNIOTIC SPACE THAT BYPASSES THE BLADDER OBSTRUCTION, IMPROVES AMNIOTIC FLUID VOLUME, AND RESCUES LUNG DEVELOPMENT DURING GESTATION. EXISTING VAS ARE ASSOCIATED WITH A DISLODGEMENT RATE UP TO 80%, WHICH OFTEN NECESSITATES REPEAT INVASIVE PROCEDURES TO REPLACE THE SHUNT. DUE TO THE RISKS OF THE OPERATION AND ITS HIGH INHERENT FAILURE RATE, VAS TREATMENT IS TYPICALLY PERFORMED IN THE MOST SEVERE LUTO CASES (~10%). THIS INDICATES A LARGE UNMET NEED. VORTEX MEDICAL IS DEVELOPING A NOVEL FETAL VAS THAT INCORPORATES ENHANCED ANCHORS (FIXATION) TO REDUCE DISLODGEMENT, MATERIALS THAT ENHANCE THE SHUNT'S VISIBILITY ON ULTRASOUND TO OPTIMIZE SHUNT DEPLOYMENT, AND A REINFORCED CHANNEL THAT RESISTS KINKING AND CAN EXTEND AS THE FETUS GROWS. WE HAVE PROTOTYPED THE DESIGN AND TESTED THE DEVICE'S PERFORMANCE IN BENCH TESTS AND A PILOT STUDY IN FETAL SHEEP. THESE STUDIES SUGGEST THE VORTEX SHUNT IS SUPERIOR TO CURRENTLY AVAILABLE SHUNTS, DELIVERING PROOF-OF-CONCEPT FOR OUR DESIGN. IN THE PROPOSED FAST-TRACK SBIR PROJECT, WE WILL REFINE THE DESIGN OF THE VORTEX SHUNT AND COMPLETE PRECLINICAL TESTING. IN PHASE I, WE WILL OPTIMIZE THE DESIGN OF THE CONDUIT AND THE METHOD FOR JOINING THE CONDUIT AND ANCHORS. WE WILL SUBJECT PROTOTYPES TO GESTATION-EQUIVALENT FATIGUE AND THEN VERIFY PERFORMANCE TO ENSURE THE DESIGN IS ROBUST TO FETAL MOVEMENTS. SUBSEQUENTLY, WE WILL HOLD A PRE-SUBMISSION MEETING WITH THE FDA TO SOLIDIFY THE PRECLINICAL TESTING PLAN. IN PHASE II, WE WILL OPTIMIZE THE DESIGN OF THE DELIVERY SYSTEM, DEVELOP SCALABLE MANUFACTURING METHODS, CONDUCT VERIFICATION AND VALIDATION TESTING, AND COMPLETE USABILITY STUDIES WITH FETAL SURGEONS IN A SIMULATED CLINICAL ENVIRONMENT. THESE EFFORTS WILL PROVIDE THE FOUNDATION FOR OUR IDE APPLICATION TO THE FDA TO BEGIN FIRST-IN-HUMAN TRIALS. THE VORTEX SHUNT WILL FOLLOW THE SAME REGULATORY PATHWAY AS CURRENT SHUNTS WITH A HUMANITARIAN USE DESIGNATION (HUD). THE PROPOSED EFFORTS WILL LAY THE GROUNDWORK TO BRING THE VORTEX SHUNT ONE STEP CLOSER TO IMPACTING THE LONG-TERM OUTCOMES FOR PRENATAL LUTO PATIENTS. THE VORTEX SHUNT WILL IMPROVE THE EFFICACY OF PRENATAL LUTO TREATMENT, WHICH WILL REDUCE MORTALITY AND COMPLICATIONS AND RESULT IN HEALTHCARE SAVINGS OF MILLIONS OF DOLLARS ANNUALLY IN THE US ALONE. FURTHERMORE, BY IMPROVING THE SAFETY AND RELIABILITY OF VAS THERAPY, IT WILL EXTEND THE POTENTIAL FOR TREATMENT TO MANY PATIENTS WHO CURRENTLY HAVE NO OPTION.

DEVELOPMENT OF A NOVEL MYC INHIBITOR FOR CANCER THERAPY - SUMMARY MYC PROTEINS (INCLUDING C-MYC, N-MYC AND L-MYC) ARE CRITICAL ONCOGENIC DRIVERS THAT REGULATE MULTIPLE CANCER HALLMARKS. THE EVIDENCE INDICATING THAT MYC IS A CRITICAL ONCOGENIC DRIVER THAT REGULATES MULTIPLE CANCER HALLMARKS IS COMPELLING. RECENT PAN-CANCER ANALYSES OF OVER 9,000 HUMAN CANCERS OF VARIOUS TYPES FOUND AMPLIFICATION OF MYC GENES IN ~28% OF ALL CASES. IN ADDITION, MULTIPLE MECHANISMS EXIST IN TUMOR CELLS THAT FREQUENTLY LEAD TO THE UPREGULATION OF MYC MRNA AND PROTEIN EXPRESSION, LEADING TO ESTIMATES THAT MYC PROTEINS ARE INVOLVED IN AT LEAST 70% OF ALL HUMAN CANCERS. MYC IS PARTICULARLY IMPORTANT IN MANY THERAPY-RESISTANT CANCERS. FOR EXAMPLE, IN CASTRATION-RESISTANT PROSTATE CANCER (CRPC), C-MYC IS AMPLIFIED IN 45% OF CASES, WHILE IN LATE-STAGE NEUROENDOCRINE PROSTATE CANCER (NEPC), N-MYC IS OVEREXPRESSED IN 40% OF CASES. IN NON-SMALL CELL LUNG CANCER, MYC PROMOTES RESISTANCE TO TARGETED THERAPIES AGAINST EGFR AND ALK. IN HEPATOCELLULAR CARCINOMA (HCC), C-MYC PROTEIN IS OVEREXPRESSED IN UP TO 70% OF CASES ACROSS ALL STAGES AND GRADES, IMPLICATING MYC AS A PREVALENT, EARLY AND CRITICAL EVENT IN TUMORIGENESIS. THUS, INHIBITING MYC SYSTEMICALLY WITH A SMALL MOLECULE MYC INHIBITOR MAY LEAD TO PROFOUND ANTITUMOR ACTIVITY ACROSS MANY CANCER TYPES. HOWEVER, TO- DATE, NO SMALL MOLECULE MYC INHIBITOR HAS BEEN DEVELOPED INTO THE CLINIC. TO ADDRESS THIS DRUG TARGET, WE SET OUT TO DEVELOP SMALL MOLECULE MYC INHIBITORS SUITABLE FOR DEVELOPMENT AS A NEW THERAPEUTIC FOR CANCER. AFTER IMPLEMENTING A NOVEL IN SILICO SCREEN, NOVEL IN VIVO TESTING, EXTENSIVE MEDICINAL CHEMISTRY OPTIMIZATION, AND THOROUGH IN VITRO AND IN VIVO CHARACTERIZATION, WE DEVELOPED A NOVEL SERIES OF DIRECT SMALL MOLECULE MYC INHIBITORS THAT DEMONSTRATE PROFOUND ANTITUMOR EFFICACY IN MYC-DRIVEN MODELS OF PROSTATE, LIVER, AND OTHER TUMOR TYPES. OUR LEAD COMPOUND, MYCI606, COMPLETELY ELIMINATES HCC TUMORS IN MULTIPLE SYNGENEIC MODELS AND INDUCES IMMUNOLOGICAL MEMORY IN HCC, SUGGESTING THIS COMPOUND HAS THE POTENTIAL TO BE AN EXTREMELY IMPACTFUL NEW THERAPEUTIC FOR LIVER CANCER. VORTEX THERAPEUTICS HAS INITIATED IND-ENABLING STUDIES ON MYCI606. IN THIS PROPOSAL, WE SEEK FUNDING TO CONTINUE THIS THE DEVELOPMENT OF MYCI606 BY COMPLETING PROCESS DEVELOPMENT AND GLP TOXICOLOGY STUDIES. THESE EFFORTS WILL POSITION US FOR FILING AN IND IN THE NEAR-TERM TO STUDY THE FIRST DIRECT MYC INHIBITOR IN HUMAN CLINICAL TRIALS.

YOUTH BUILD

HEALTH CENTER CLUSTER

CONTINUUM OF CARE PROGRAM

CAROL M. WHITE PHYSICAL EDUCATION PROGRAM

ADVANCED INDOOR NAVIGATION AID FOR BLIND AND VISUALLY-IMPAIRED INDIVIDUALS IN UNFAMILIAR SPACES

CONTINUUM OF CARE PROGRAM

DIRECT SERVICES FOR SURVIVORS OF TORTURE, INCLUDING HOLISTIC PSYCHOLOGICAL, SOCIAL, LEGAL, MEDICAL SERVICES AND TRAINING.

CONTINUUM OF CARE PROGRAM

YOUTH BUILD

VA SUPPORTIVE SERVICES FOR VETERAN FAMILIES PROGRAM

REAP RENEWABLE ENERGY SYSTEM (RES) GRANT UNRESTRICTED AMOUNT

REAP RENEWABLE ENERGY SYSTEM (RES) GRANT UNRESTRICTED AMOUNT

VA SUPPORTIVE SERVICES FOR VETERAN FAMILIES PROGRAM

CURRENT ENERGY HARNESSING USING SYNERGISTIC KINEMATICS OF SCHOOLS OF FISH-SHAPED BODIES

HEMATOLOGIC CANCERS-STRATEGIES FOR EDUCATION & OUTREACH

PURPOSE WITH THE SUPPORT OF THE LOCAL FOOD PROMOTION PROGRAM (LFPP), FLAVORS LLC., WILL SUPPORT 150 BIPOC LOCAL GROWERS, FARMERS, AND FOOD BUSINESS ENTERPRISES IN THE GREATER PRINCE GEORGE S COUNTY REGION BY LAUNCHING A HYBRID 12 WEEK CULINARY MICRO ENTERPRISE PROGRAM. THIS PROGRAM WILL IMPROVE BUSINESS DEVELOPMENT KNOWLEDGE AND GROWTH STRATEGIES TO HELP GROW AND SCALE A PROFITABLE AGRICULTURE AND CULINARY BUSINESS THROUGH WEEKLY WORKSHOPS LED BY FIELD EXPERTS. PROVIDE EQUITABLE ACCESS TO LOCAL GROWERS, FARMERS, AND CULINARY BUSINESS ADVISORS AND FUNDING OPPORTUNITIES THROUGH COLLABORATIVE COMMUNITY PARTNERSHIPS. DEVELOP AND LAUNCH THE FLAVORS WEB AND APP BASED VIRTUAL EDUCATION PLATFORM FOR PROGRAM DELIVERY TO LOCAL GROWERS, FARMERS , AND BIPOC FOOD BUSINESS ENTERPRISES TO CONNECT, NETWORK, AND EXPAND THEIR BUSINESS OPPORTUNITIES WITH FOOD AND BEVERAGE ENTREPRENEURS, INDUSTRY LEADERS, CAPITAL AND INVESTMENT RESOURCES, AND SERVICE PROVIDERS NATIONWIDE. ACTIVITIES DESIGN AND LAUNCH VIRTUAL EDUCATION PLATFORM FOR PROGRAM DELIVERY MARKET INCUBATOR PROGRAM ENROLL 25 PARTICIPANTS INTO THE WINTER COHORT, AND EACH COHORT THEREAFTER DISTRIBUTE COURSE MATERIALS HOST ORIENTATION AND NETWORKING EVENT FOR PARTICIPANTS TO MEET INSTRUCTORS AND COLLABORATORS. PROVIDE LIVE DEMO SESSION TO COURSE PARTICIPANTS TO UNDERSTAND HOW PLATFORM WORKS START LIVE WEEKLY WORKSHOP SESSIONS LED BY INSTRUCTORS. ONE NEW CLASS PER WEEK FOR 12 WEEKS. BIWEEKLY ONE ON ONE CHECK INS WITH LEAD INSTRUCTOR ATTEND 3 SITE VISITS TO LOCAL PRODUCE MARKETS, FOOD SUPPLIERS AND DEPOTS, AND TOUR SINCERELY WILMA E COMMERCE PANCAKE AND WAFFLE BATTER FACILITY DEVELOP BUSINESS PLANS, GROWTH AND FUNDING STRATEGIES FOR PARTICIPANTS COMPLETE POST ASSESSMENTS FOR BUSINESS PLANS, AND FINANCIAL ACCOUNTING SYSTEMS (QUICKBOOKS) WEEKLY PROJECT MANAGEMENT MEETINGS WITH INSTRUCTORS, PROGRAM ADMINISTRATOR, GRANTS MANAGER, AND CEO TO MONITOR STUDENT PERFORMANCE, CONDUCT VIRTUAL PROGRAM MONITORING VISITS, AND RECONCILIATION OF CHARGES FINAL PRESENTATIONS AND GRADUATION CEREMONY RECONCILE ALL FINAL CHARGES, COMPLETE MANDATORY GRANT REPORTING DELIVERABLES 1. DELIVERY OF A VIRTUAL EDUCATION E LEARNING PLATFORM FOR CONTENT DELIVERY AND ACCESS TO BUSINESS DEVELOPMENT RESOURCES FOR LIFETIME ACCESS FOR PARTICIPANTS 2. DELIVERY OF SIX (6), 12 WEEK TECHNICAL INCUBATOR COHORTS ( 3 COHORTS EACH YEAR FOR 2 YEARS) EXPECTED OUTCOMES 1.DEVELOP BUSINESS PLANS 2.FACILITATE REGIONAL FOOD CHAIN COORDINATION AND INCREASE CAPACITY OF DIRECT TO CONSUMER ENTITIES 3.DEVELOP THE MARKET FOR LOCAL REGIONAL AGRICULTURAL PRODUCTS 4.INCREASE VIABILITY OF LOCAL REGIONAL PRODUCERS AND PROCESSORS 5.IMPROVE FOOD SAFETY OF LOCAL REGIONAL AGRICULTURAL PRODUCTS 6.EXPAND CONSUMER PRODUCT GOODS (CPG) MANUFACTURERS THAT BEGIN TO MAKE E COMMERCE SALES AND NUMBER OF FOOD TRUCKS LAUNCHED INTENDED BENEFICIARIES THE MAIN BENEFICIARIES OF THIS PROJECT WILL BE BLACK, INDIGENOUS, AND PEOPLE OF COLOR (BIPOC) FOOD BUSINESS ENTERPRISES AND THE LOCAL GROWER AND FARMER COMMUNITY AS THIS PROGRAM WAS DESIGNED SPECIFICALLY WITH THIS TARGET POPULATION IN MIND. PARTICIPANTS IN THE 12 WEEK INCUBATOR PROGRAM WILL RECEIVE THE EDUCATION, RESOURCES, AND MENTORSHIP THEY NEED TO CREATE EFFICIENT, STRATEGIC AND SUSTAINABLE CULINARY BUSINESSES. WITH THE EXPERIENCE AND RESOURCES WITH THIS PROGRAM, FLAVORS WILL HELP MITIGATE THE BARRIERS TO SUCCESS, SUCH AS ACCESS TO CAPITAL AND COMMERCIAL KITCHEN SPACE THROUGH COLLABORATIVE COMMUNITY PARTNERSHIPS.

YOUTH BUILD

CONSUMER RIGHTS FOR DOMESTIC & SEXUAL VIOLENCE SURVIVORS INITIATIVE

THE ROLE OF MUTATIONS IN BRCA2 AND OTHER KNOWN AND NOVEL CANCER SUSCEPTIBILITY GENES IN INHERITED RISK FOR LETHAL PROSTATE CANCER

PURPOSE: THE CONTINUUM OF CARE (COC) PROGRAM IS DESIGNED TO PROMOTE COMMUNITY-WIDE COMMITMENT TO THE GOAL OF ENDING HOMELESSNESS; PROVIDE FUNDING FOR EFFORTS BY NONPROFIT PROVIDERS, STATES, AND LOCAL GOVERNMENTS TO QUICKLY HOUSE HOMELESS INDIVIDUALS AND FAMILIES WHILE MINIMIZING THE TRAUMA AND DISLOCATION CAUSED TO HOMELESS INDIVIDUALS, FAMILIES, AND COMMUNITIES BY HOMELESSNESS; PROMOTE ACCESS TO AND EFFECTIVE UTILIZATION OF MAINSTREAM PROGRAMS BY HOMELESS INDIVIDUALS AND FAMILIES; AND OPTIMIZE SELF-SUFFICIENCY AMONG INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS. THE COC PROGRAM INCLUDES GRANTS THAT ARE AVAILABLE TO SPECIFIC SUBPOPULATIONS OF PEOPLE EXPERIENCING HOMELESSNESS. THE GRANTS SPECIFICALLY SERVE YOUTH, DEFINED AS HOUSEHOLDS WHERE NO PERSON IS OVER THE AGE OF 24 UNDER THE YOUTH HOMELESS DEMONSTRATION PROGRAM (YHDP). THE GOAL OF THE YOUTH HOMELESSNESS DEMONSTRATION PROGRAM (YHDP) IS TO SUPPORT THE DEVELOPMENT AND IMPLEMENTATION OF A COORDINATED COMMUNITY APPROACH TO PREVENTING AND ENDING YOUTH HOMELESSNESS AND SHARING THAT EXPERIENCE WITH AND MOBILIZING COMMUNITIES AROUND THE COUNTRY TOWARD THE SAME END. THE NOTICE OF FUNDING OPPORTUNITY (NOFO) FOR NEW YHDP GRANTS IS FOUND AT HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/YHDP (CHOOSE THE MOST RECENT YHDP NOFO LISTED). THE NOFO FOR YHDP RENEWALS AND REPLACEMENTS IS FOUND AT HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/COC/COMPETITION (CHOOSE THE MOST RECENT COC/YHDP RENEWAL OR REPLACEMENT NOFO LISTED).; ACTIVITIES TO BE PERFORMED: THESE GRANTS MAY BE USED TO PAY FOR THE ELIGIBLE COSTS USED TO ESTABLISH AND OPERATE PROJECTS UNDER FIVE PROGRAM COMPONENTS: 1. PERMANENT HOUSING, WHICH INCLUDES PERMANENT SUPPORTIVE HOUSING FOR PERSONS WITH DISABILITIES, AND RAPID REHOUSING; 2. TRANSITIONAL HOUSING; 3. SUPPORTIVE SERVICES ONLY; 4. HOMELESS MANAGEMENT INFORMATION SYSTEMS (HMIS); AND 5. HOMELESSNESS PREVENTION (IN SOME CASES). ELIGIBLE COSTS WITHIN THESE PROJECTS INCLUDE: 1. LEASING OF A STRUCTURE OR STRUCTURES, OR PORTIONS THEREOF, TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; 2. RENTAL ASSISTANCE, WHICH MAY BE SHORT-TERM, MEDIUM-TERM, OR LONG-TERM, AS WELL AS TENANT-BASED, PROJECT-BASED, OR SPONSOR-BASED, FOR TRANSITIONAL OR PERMANENT HOUSING; 3. SUPPORTIVE SERVICES TO ASSIST PROGRAM PARTICIPANTS OBTAIN AND MAINTAIN HOUSING; 4. OPERATING COSTS OF SUPPORTIVE HOUSING; 5. COSTS OF IMPLEMENTING AND OPERATING HMIS; 6. PROJECT ADMINISTRATIVE COSTS; 7. RELOCATION COSTS; AND 8. INDIRECT COSTS IN ACCORDANCE WITH 2 CFR PARTS 200, AS APPLICABLE. IN ADDITION TO USING GRANT FUNDS FOR THE ELIGIBLE COSTS DESCRIBED ABOVE, RECIPIENTS AND SUBRECIPIENTS IN CONTINUUMS OF CARE DESIGNATED AS HIGH PERFORMING COMMUNITIES MAY ALSO USE GRANT FUNDS TO PROVIDE HOUSING RELOCATION AND STABILIZATION SERVICES AND SHORT- AND/OR MEDIUM-TERM RENTAL ASSISTANCE TO YOUTH AT RISK OF HOMELESSNESS AS SET FORTH IN 24 CFR 576.103 AND 24 CFR 576.104, IF NECESSARY TO PREVENT YOUTH FROM BECOMING HOMELESS. NO ASSISTANCE PROVIDED UNDER PROGRAM (OR ANY STATE OR LOCAL GOVERNMENT FUNDS USED TO SUPPLEMENT THIS ASSISTANCE) MAY BE USED TO REPLACE STATE OR LOCAL FUNDS PREVIOUSLY USED, OR DESIGNATED FOR USE, TO ASSIST HOMELESS PERSONS OR PERSONS AT-RISK OF HOMELESSNESS.; EXPECTED OUTCOMES: DECREASE IN THE NUMBER OF YOUTH EXPERIENCING HOMELESSNESS, MORE SPECIFICALLY USING PERFORMANCE INDICATORS SUCH AS THE LENGTH OF TIME HOMELESS, RETURNS TO HOMELESSNESS OVER TIME, AND EXITS TO PERMANENT HOUSING. COC PERFORMANCE PROFILE REPORTS CAN BE FOUND AT: HTTPS://WWW.HUDEXCHANGE.INFO/PROGRAMS/COC/COC-PERFORMANCE-PROFILE-REPORTS/; INTENDED BENEFICIARIES: YOUTH DEFINED AS HOUSEHOLDS WHERE NO PERSON IS OVER THE AGE OF 24; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD

THE NATIONAL LGBTQ DV CAPACITY BUILDING LEARNING CENTER

THE RURAL DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, AND STALKING PROGRAM (RURAL PROGRAM) IS AUTHORIZED BY 34 U.S.C. 12341. RURAL PROGRAM FUNDS ARE USED TO SUPPORT PROGRAMS THAT: 1) IDENTIFY, ASSESS, AND APPROPRIATELY RESPOND TO CHILD, YOUTH, AND ADULT VICTIMS OF DOMESTIC VIOLENCE, SEXUAL ASSAULT, DATING VIOLENCE, AND STALKING IN RURAL COMMUNITIES; 2) ESTABLISH AND EXPAND VICTIM SERVICES IN RURAL COMMUNITIES TO CHILD, YOUTH, AND ADULT VICTIMS; 3) INCREASE THE SAFETY AND WELL-BEING OF WOMEN AND CHILDREN IN RURAL COMMUNITIES, BY (A) DEALING DIRECTLY AND IMMEDIATELY WITH DOMESTIC VIOLENCE, SEXUAL ASSAULT, DATING VIOLENCE, AND STALKING; AND (B) CREATING AND IMPLEMENTING STRATEGIES TO INCREASE AWARENESS AND PREVENT THESE CRIMES; AND 4) DEVELOP, EXPAND, IMPLEMENT, AND IMPROVE THE QUALITY OF SEXUAL ASSAULT FORENSIC MEDICAL EXAMINATION OR SEXUAL ASSAULT NURSE EXAMINER PROGRAMS. GRANTEES MUST USE AT LEAST ONE OF THE FOLLOWING STRATEGIES IN IMPLEMENTING THEIR PROJECTS: 1) IMPLEMENT, EXPAND, AND ESTABLISH COOPERATIVE EFFORTS AND PROJECTS AMONG LAW ENFORCEMENT OFFICERS, PROSECUTORS, VICTIM SERVICE PROVIDERS, AND OTHER RELATED PARTIES TO INVESTIGATE AND PROSECUTE INCIDENTS OF DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, AND STALKING; 2) PROVIDE TREATMENT, COUNSELING, ADVOCACY, LEGAL ASSISTANCE, AND OTHER LONG-TERM AND SHORT-TERM VICTIM AND POPULATION SPECIFIC SERVICES TO ADULT AND MINOR VICTIMS OF DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, AND STALKING IN RURAL COMMUNITIES; 3) WORK IN COOPERATION WITH THE COMMUNITY TO DEVELOP EDUCATION AND PREVENTION STRATEGIES DIRECTED TOWARD SUCH ISSUES; 4) DEVELOP, ENLARGE, OR STRENGTHEN PROGRAMS ADDRESSING SEXUAL ASSAULT; AND 5) DEVELOP PROGRAMS AND STRATEGIES THAT FOCUS ON THE SPECIFIC NEEDS OF VICTIMS OF WHO RESIDE IN REMOTE RURAL AND GEOGRAPHICALLY ISOLATED AREAS. WITH THIS CONTINUATION RURAL DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, AND STALKING GRANT AWARD, THE SURVIVOR ADVOCACY OUTREACH PROGRAM, IN PARTNERSHIP WITH THE ATHENS COUNTY FOUNDATIONS RACIAL EQUITY COALITION OF ATHENS COUNTY, WILL IMPLEMENT A PROJECTFOR NINE COUNTIES IN SOUTHEASTERN OHIO THATFOCUSES ON CULTURALLY SPECIFIC POPULATIONS WITHIN THE SERVICE AREAS AND INCREASING STAFFING LEVELS AT THE ATHENS COUNTY CHILD ADVOCACY CENTER. SPECIFIC ACTIVITIES WILL INCLUDE: 1) MOBILE COMMUNITY ADVOCACY, WHERE STAFF MEETS WITH CLIENTS AT SAFE LOCATIONS IN THEIR HOME COMMUNITY TO DELIVER THE INTERVENTION; 2) COMMUNITY ENGAGEMENT, WHICH INVOLVES ADVOCATES TRAVELING INTO THE COMMUNITY WITH SURVIVORS TO ACCESS SERVICES AND CULTIVATING RELATIONSHIPS WITH COMMUNITY MEMBERS AND ORGANIZATIONS TO IMPROVE CCR; AND 3) FUNDINGTHREE ADVOCATES, THE PARTIAL SALARY OF A FORENSIC INTERVIEWER, A CONTRACTUAL PSANE, SUPPORT HELPLINE/TEXT LINE CONTRACTUAL WORKERS, AND THE RACIAL EQUITY COALITION COORDINATOR. THE TIMING FOR PERFORMANCE OF THIS AWARD IS 36 MONTHS.

YOUTH HOMELESSNESS DEMONSTRATION PROGRAM

FAMILY ENDEAVORS INC., DBA ENDEAVORS, PROPOSES TO EXTEND HVRP SERVICES TO HOMELESS VETERANS (CATEGORY 1) WHO RESIDE IN THE PIMA, COUNTY. THE PURPOSE OF OUR PROJECT IS TO HELP VETERANS ACHIEVE ECONOMIC PROSPERITY AND ADDRESS HISTORICAL INEQUITIES. ENDEAVORS GOAL FOR THE HVRP PROGRAM IS TO FACILITATE HIGH-QUALITY CAREER OUTCOMES FOR VETERAN EXPERIENCING HOMELESSNESS. OUR PRIMARY STRATEGIES ARE 1) PREPARE AND CONNECT PARTICIPANTS TO JOB TRAINING AND COMPETITIVE EMPLOYMENT OPPORTUNITIES 2) USE MULTI-DISCIPLINARY APPROACHES TO IDENTIFY AND ADDRESS BARRIERS TO EMPLOYMENT AND JOB RETENTION, SUCH AS PREVIOUS INCARCERATION AND SUBSTANCE USE DISORDERS, AND 3) CREATE LINKAGE TO HOUSING. ENDEAVORS WILL COORDINATE JOB PLACEMENT ASSISTANCE WITH THE AMERICAN JOB CENTERS IN ARIZONA AND OTHER MEMBERS OF THE WORKFORCE DEVELOPMENT SYSTEM. ASSISTING VETERANS IN ESTABLISHING AND MAINTAINING A WORKING LIFE REQUIRES A BASIC UNDERSTANDING OF MILITARY CULTURE POSITION. WE HAVE A COMMITMENT TO ARIZONA S VETERANS TO IMPROVE THEIR QUALITY OF LIFE WITH FAIR AND DIGNIFIED TREATMENT. CASE MANAGEMENT SERVICES WORKSHOPS (VIRTUAL, HYBRID, AND IN-PERSON) ON-THE-JOB TRAINING, CAREER COUNSELING, CHILDCARE, TRANSPORTATION, WORK CLOTHES, RESUME BUILDING, FINANCIAL ASSISTANCE UPON ELIGIBILITY, JOB PLACEMENT THROUGH AMERICAN JOB CENTERS AND OTHER WORKFORCE ORGANIZATION, AND SUPPORT SERVICES. WE WILL BE IMPACTING 58 VETERANS PER YEAR IN TUCSON, ARIZONA. ENDEAVORS WILL PROJECT TO IMPACT 58 HOMELESS VETERANS IN THE PERIOD OF PERFORMANCE. WE EXPECT TO HAVE AN OVERALL PLACEMENT RATE OF 66.7%.ARIZONA COALITION FOR MILITARY FAMILIES, DISABLED AMERICAN VETERANS, VETERAN AFFAIRS, TUCSON VETERANS SERVING VETERANS, AND TUCSON VETERANS.SUBRECIPIENT ACTIVITIES, IF APPLICABLE: N ARECIPIENT OF OTHER FUNDING: N A

SERVICES FOR SURVIVORS OF TORTURE PROGRAM

YOUTH BUILD

CONTEXT UNDERSTANDING TECHNOLOGY TO IMPROVE INTERNET ACCESSIBILITY FOR USERS WITH

SURVIVORS TO ENTREPRENEURS (S2E) PROGRAM

ENERGY-EFFICIENT HYBRID MEDIUM AND HEAVY DUTY VEHICLE POWER SYSTEMS

PURPOSE: THE CONTINUUM OF CARE (COC) PROGRAM IS DESIGNED TO PROMOTE COMMUNITY-WIDE COMMITMENT TO THE GOAL OF ENDING HOMELESSNESS; PROVIDE FUNDING FOR EFFORTS BY NONPROFIT PROVIDERS, STATES, AND LOCAL GOVERNMENTS TO QUICKLY HOUSE HOMELESS INDIVIDUALS AND FAMILIES WHILE MINIMIZING THE TRAUMA AND DISLOCATION CAUSED TO HOMELESS INDIVIDUALS, FAMILIES, AND COMMUNITIES BY HOMELESSNESS; PROMOTE ACCESS TO AND EFFECTIVE UTILIZATION OF MAINSTREAM PROGRAMS BY HOMELESS INDIVIDUALS AND FAMILIES; AND OPTIMIZE SELF-SUFFICIENCY AMONG INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS. THE MOST RECENT COC AWARD ANNOUNCEMENT LISTING AWARDS BY STATE AND COC IS ACCESSIBLE AT HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/COC/AWARDS. SELECT THE LINK UNDER THE FUNDING AND AWARD INFORMATION SECTION FOR THE APPROPRIATE FISCAL YEAR.; ACTIVITIES TO BE PERFORMED: CONTINUUM OF CARE PROGRAM FUNDS MAY BE USED TO PAY FOR THE ELIGIBLE COSTS USED TO ESTABLISH AND OPERATE PROJECTS UNDER FIVE PROGRAM COMPONENTS: (1) PERMANENT HOUSING, WHICH INCLUDES PERMANENT SUPPORTIVE HOUSING FOR PERSONS WITH DISABILITIES, AND RAPID REHOUSING; (2) TRANSITIONAL HOUSING; (3) SUPPORTIVE SERVICES ONLY; (4) HOMELESS MANAGEMENT INFORMATION SYSTEMS (HMIS), AND (5) IN SOME CASES, HOMELESSNESS PREVENTION. THIRTEEN TYPES OF ASSISTANCE MAY BE PROVIDED THROUGH THE CONTINUUM OF CARE (COC) PROGRAM: (1) COC PLANNING ACTIVITIES/COSTS FOR DESIGNING AND CARRYING OUT A COLLABORATIVE PROCESS FOR THE DEVELOPMENT OF AN APPLICATION TO HUD; (2) UNITED FUNDING AGENCY (UFA) COSTS FOR FISCAL CONTROL AND ACCOUNTING NECESSARY TO ASSURE THE PROPER DISBURSAL OF, AND ACCOUNTING FOR, FEDERAL FUNDS AWARDED TO SUBRECIPIENTS UNDER THE CONTINUUM OF CARE PROGRAM, (3) ACQUISITION OF REAL PROPERTY (INCLUDING STRUCTURES) FOR USE IN THE PROVISION OF HOUSING OR SUPPORTIVE SERVICES; (4) REHABILITATION OF STRUCTURES TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (5) NEW CONSTRUCTION, INCLUDING THE BUILDING OF A NEW STRUCTURE OR BUILDING AN ADDITION TO AN EXISTING STRUCTURE FOR USE AS SUPPORTIVE HOUSING; (6) LEASING OF A STRUCTURE OR STRUCTURES, OR PORTIONS THEREOF, TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (7) RENTAL ASSISTANCE, WHICH MAY BE SHORT-TERM, MEDIUM-TERM, OR LONG-TERM, AS WELL AS TENANT-BASED, PROJECT-BASED, OR SPONSOR-BASED, FOR TRANSITIONAL OR PERMANENT HOUSING; (8) SUPPORTIVE SERVICES TO ASSIST PROGRAM PARTICIPANTS OBTAIN AND MAINTAIN HOUSING; (9) OPERATING COSTS OF SUPPORTIVE HOUSING; (10) COSTS OF IMPLEMENTING AND OPERATING HMIS; (11) PROJECT ADMINISTRATIVE COSTS; (12) RELOCATION COSTS; AND (13) INDIRECT COSTS IN ACCORDANCE WITH 2 CFR PARTS 200, AS APPLICABLE. IN ADDITION TO USING GRANT FUNDS FOR THE ELIGIBLE COSTS DESCRIBED ABOVE, RECIPIENTS AND SUBRECIPIENTS IN CONTINUUMS OF CARE DESIGNATED AS HIGH PERFORMING COMMUNITIES MAY ALSO USE GRANT FUNDS TO PROVIDE HOUSING RELOCATION AND STABILIZATION SERVICES AND SHORT- AND/OR MEDIUM-TERM RENTAL ASSISTANCE TO INDIVIDUALS AND FAMILIES AT RISK OF HOMELESSNESS AS SET FORTH IN 24 CFR 576.103 AND 24 CFR 576.104, IF NECESSARY TO PREVENT THE INDIVIDUAL OR FAMILY FROM BECOMING HOMELESS. LIMITATION ON USE OF FUNDS: NO ASSISTANCE PROVIDED UNDER PROGRAM (OR ANY STATE OR LOCAL GOVERNMENT FUNDS USED TO SUPPLEMENT THIS ASSISTANCE) MAY BE USED TO REPLACE STATE OR LOCAL FUNDS PREVIOUSLY USED, OR DESIGNATED FOR USE, TO ASSIST HOMELESS PERSONS OR PERSONS AT-RISK OF HOMELESSNESS.; EXPECTED OUTCOMES: DECREASE IN THE NUMBER INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS, MORE SPECIFICALLY USING PERFORMANCE INDICATORS SUCH AS THE LENGTH OF TIME HOMELESS, RETURNS TO HOMELESSNESS OVER TIME, AND EXITS TO PERMANENT HOUSING. COC PERFORMANCE PROFILE REPORTS CAN BE FOUND AT HTTPS://WWW.HUDEXCHANGE.INFO/PROGRAMS/COC/COC-PERFORMANCE-PROFILE-REPORTS/.; INTENDED BENEFICIARIES: INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

CONTINUUM OF CARE PROGRAM

MCH RESEARCH

CULTURALLY SPECIFIC SERVICES FOR LESBIAN, BISEXUAL, TRANS & GAY SURVIVORS OF ABUSE

FAVOR HEALTH, EDUCATION, AND LINKAGES TO SUPPORT (FAVOR HEALS)

CONTINUUM OF CARE PROGRAM

A NOVEL APPROACH TO RESTRICTING THE SPREAD OF NEUROFIBRILLARY TAU - 7. PROJECT SUMMARY ALZHEIMER’S DISEASE (AD) IS THE MOST COMMON CAUSE OF DEMENTIA AND IS A GROWING PROBLEM AS POPULATIONS AGE. MORE THAN 25 MILLION PEOPLE ARE AFFECTED BY DEMENTIA WORLDWIDE WITH MOST SUFFERING FROM AD. AD IS CHARACTERIZED BY THE PRESENCE OF PLAQUES OF INSOLUBLE AMYLOID-BETA (ASS) AND TANGLES OF HYPERPHOSPHORYLATED AGGREGATES OF THE CYTOSKELETAL PROTEIN, TAU. THUS FAR, MOST AD TREATMENTS HAVE TARGETED ASS AGGREGATION AND PLAQUE FORMATION, BUT THESE THERAPIES HAVE LARGELY FAILED TO TRANSLATE FROM PRECLINICAL RODENT MODELS TO HUMANS. INTERESTINGLY, TAU PATHOLOGY HAS BEEN SHOWN TO CORRELATE BETTER WITH COGNITIVE DECLINE THAN ASS, AND THUS RESTRICTING THE SPREAD OF NEUROFIBRILLARY TAU HAS BECOME A GROWING FOCUS FOR DEVELOPMENT OF TREATMENTS FOR VARIOUS TAUOPATHIES, INCLUDING AD. IT WAS RECENTLY DISCOVERED THAT LRP1 IS A MASTER REGULATOR OF TAU UPTAKE AND SPREAD IN THE BRAIN, INDICATING THAT LRP1 MAY BE AN IMPORTANT THERAPEUTIC TARGET FOR SLOWING THE PROGRESSION OF VARIOUS TAUOPATHIES. NOVORON BIOSCIENCE IS DEVELOPING NOVEL LARGE-MOLECULE THERAPIES TARGETING LDL RECEPTOR-RELATED PROTEIN 1 (LRP1), A MASTER REGULATOR OF TAU UPTAKE AND SPREAD IN THE BRAIN, TO SLOW THE PROGRESSION OF TAUOPATHIES SUCH AS (AD) AND IMPROVE FUNCTIONAL OUTCOMES IN PATIENTS. NOVORON’S LEAD COMPOUND, NOVO-118, IS A HIGH-AFFINITY LRP1 ANTAGONIST THAT IS ACTIVELY TAKEN UP INTO THE BRAIN VIA BOTH SUBCUTANEOUS AND INTRAVENOUS ADMINISTRATION. THE PURPOSE OF THIS PROPOSAL IS TO EVALUATE THE THERAPEUTIC POTENTIAL OF NOVO-118 BY ASSESSING ITS ABILITY TO RESTRICT THE SPREAD OF TAU IN THE RODENT BRAIN. WE WILL ACCOMPLISH THIS BY UNCOUPLING PROOF OF CONCEPT STUDIES FOR EFFECTIVE TAU RESTRICTION FROM ASSESSMENT OF TRANSLATABILITY IN TERMS OF CLINICALLY RELEVANT UTILIZATION. TO ACCOMPLISH THIS, WE HAVE DESIGNED THIS PROJECT WITH TWO PRIMARY GOALS: 1) GENERATE NECESSARY PROOF OF CONCEPT DEMONSTRATING THE ABILITY OF NOVO-118 TO ABROGATE TAU SPREAD; AND 2) DE-RISK THE TECHNOLOGY BY DEMONSTRATING THAT WE CAN DELIVER THE DRUG AND ELICIT BENEFIT IN A CLINICALLY TRANSLATABLE FASHION.

HERE FOR YOU PROJECT - THE "HERE FOR YOU" PROJECT WILL STRENGTHEN THE ABILITY OF SUMMIT COUNTY, OHIO'S COMMUNITY MENTAL HEALTH SYSTEM TO PROVIDE CARE FOR INDIGENT, LOW AND MODERATE INCOME PEOPLE, MINORITIES, AND OTHER VULNERABLE POPULATIONS WHO ARE EXPERIENCING SERIOUS MENTAL ILLNESS, SERIOUS EMOTIONAL DISTURBANCE, AND CO-OCCURRING DISORDERS, WHILE RESTORING AND SUPPORTING CLINICAL SERVICES THAT WERE IMPACTED BY COVID-19. THE PROJECT WILL ESTABLISH, STRENGTHEN AND SUSTAIN TELEHEALTH CAPABILITIES, EXPAND CAPACITY TO ADDRESS CRISIS AND EMERGENCY RESPONSE, ENGAGE WITH THE COMMUNITY TO CREATE REFERRAL PATHWAYS TO GAIN AND RETAIN MINORITY AND DISADVANTAGED CLIENTS SO THAT THEY CAN RECEIVE HIGH QUALITY PATIENT CENTERED OUTPATIENT SERVICES, TRAUMA-INFORMED SCREENING, ASSESSMENT, DIAGNOSIS AND PATIENT CENTERED TREATMENT PLANNING AND TREATMENT DELIVERY, AND CLINICAL AND RECOVERY SUPPORT SERVICES. IN SUPPORT OF THOSE SERVICES, RESOURCES TO ADDRESS THE MENTAL HEALTH NEEDS OF OUR CMHC STAFF WILL BE DEVELOPED AND MADE AVAILABLE TO TEAM MEMBERS. STRATEGIES AND INTERVENTIONS TO BE EMPLOYED INCLUDE PUBLIC EDUCATION, COGNITIVE BEHAVIORAL THERAPY, DIALECTICAL BEHAVIORAL THERAPY, MOTIVATIONAL INTERVIEWING, SCREENING BRIEF INTERVENTION AND REFERRAL TO TREATMENT (SBIRT), PEER SUPPORT, TRAINING OF STAFF, AND IMPLEMENTATION OF A LIVING ROOM MODEL DROP IN/POLICE DROP OFF CENTER. PROJECT GOALS ARE TO EXPAND ACCESS TO TRAUMA INFORMED, PATIENT CENTERED OUTPATIENT SERVICES AND RECOVERY SUPPORT SERVICES FOR THE TARGET POPULATIONS, TO EXPAND CAPACITY TO ADDRESS CRISIS AND EMERGENCY RESPONSE, AND TO DEVELOP RESOURCES TO ADDRESS THE MENTAL HEALTH AND WELLBEING OF OUR CMHC TEAM MEMBERS. MEASURABLE OBJECTIVES INCLUDE STRENGTHENING AND SUSTAINING TELEHEALTH CAPABILITIES BY REPLACING NECESSARY ELECTRONIC INFRASTRUCTURE AND BY INTENSIVELY TRAINING ALL APPLICABLE STAFF PLACEMENT OF CLINICAL PROFESSIONALS AND/OR TELEHEALTH CAPABILITIES IN AT LEAST FIVE LOCATIONS CONVENIENT FOR LOW TO MODERATE INCOME FAMILIES, RACIAL MINORITIES AND OTHER VULNERABLE POPULATIONS, PROVIDE ALL STAFF SPECIFIC TRAINING ON BEHAVIORAL HEALTH DISPARITIES, INCLUDING CULTURAL AND LINGUISTIC COMPETENCE AND STRATEGIES TO ENHANCE CLIENT EXPERIENCE, AND ENGAGE AND RETAIN DIVERSE CLIENT POPULATIONS, CREATE AND IMPLEMENT AN ONGOING CYCLE OF TRAINING THAT INCLUDES ROBUST PROGRAMMING IN SELF-CARE, MEDITATION, PHYSICAL EXERCISE, LUNCH AND LEARN SESSIONS AND OTHER ACTIVITIES INTENDED TO BOOST MENTAL HEALTH AND DECREASE COMPASSION FATIGUE, ENHANCING DIVERSION FROM JAILS AND HOSPITALS BY IMPLEMENTING A LIVING ROOM MODEL DROP IN/POLICE DROP OFF CENTER, AND TO PLAN AND IMPLEMENT AN ONGOING COMMUNITY EDUCATION & OUTREACH EFFORT THAT ENGAGES THE TARGET POPULATION AND PARTNERS, AND CREATES REFERRAL PATHWAYS TO GAIN AND RETAIN MINORITY AND DISADVANTAGED CLIENTS THAT WERE LOST DURING THE PANDEMIC. THE NUMBER OF PEOPLE TO BE SERVED ANNUALLY AND OVER THE LIFE OF THE PROGRAM IS EXPECTED TO BE 1,000 UNIQUE CLIENTS AND 160 STAFF TEAM MEMBERS.

THE SSVF PROGRAM'S PURPOSE IS TO PROVIDE SUPPORTIVE SERVICES GRANTS TO PRIVATE NON-PROFIT ORGANIZATIONS AND CONSUMER COOPERATIVES, WHO WILL COORDINATE OR PROVIDE SUPPORTIVE SERVICES TO VERY LOW-INCOME VETERAN FAMILIES WHO ARE RESIDING IN PERMANENT HOUSING, ARE HOMELESS AND SCHEDULED TO BECOME RESIDENTS OF PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD; OR AFTER EXITING PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD, ARE SEEKING OTHER HOUSING THAT IS RESPONSIVE TO SUCH VERY LOW-INCOME VETERAN FAMILY'S NEEDS AND PREFERENCES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES.

THE SSVF PROGRAM'S PURPOSE IS TO PROVIDE SUPPORTIVE SERVICES GRANTS TO PRIVATE NON-PROFIT ORGANIZATIONS AND CONSUMER COOPERATIVES, WHO WILL COORDINATE OR PROVIDE SUPPORTIVE SERVICES TO VERY LOW-INCOME VETERAN FAMILIES WHO ARE RESIDING IN PERMANENT HOUSING, ARE HOMELESS AND SCHEDULED TO BECOME RESIDENTS OF PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD; OR AFTER EXITING PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD, ARE SEEKING OTHER HOUSING THAT IS RESPONSIVE TO SUCH VERY LOW-INCOME VETERAN FAMILY'S NEEDS AND PREFERENCES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES.

CONTINUUM OF CARE PROGRAM

SURVIVOR VENTURES (SV) WILL STRENGTHEN AND EXPAND ECONOMIC EMPOWERMENT SERVICES FOR TRAFFICKING SURVIVORS THROUGH THE ESTABLISHED SURVIVORS TO ENTREPRENEURS (S2E) PROGRAM IN THE METROPOLITAN STATISTICAL AREAOF HAMPTON ROADS AND THE GREATER VIRGINIA PENINSULA. S2E IS A 24-MONTH PROGRAM, ACCEPTING 35 NEW SURVIVORS EACH YEAR, THAT OCCURS IN TWO PHASES: S2E1 INVOLVES WAGE SUBSIDIES, JOB COACHING, ENTREPRENEUR MENTORSHIP, AND SPECIALIZED SKILLS TRAINING TO INCLUDE VETTED BUSINESS PLAN DEVELOPMENT AND THE OPPORTUNITY TO INCORPORATE ONES OWN BUSINESS; AND S2E2 BUILDS UPON THE SKILLS AND EXPERIENCE DERIVED IN YEAR ONE WITH A CLEAR PIPELINE TO CONNECT PARTICIPANTS WITH ADDITIONAL EXISTING SMALL BUSINESS RESOURCES TO FUND AND GROW THEIR BUSINESS. THIS PROGRAM WILL SERVE A MINIMUM OF 105 TRAFFICKING SURVIVORS TO EXPAND SERVICES TO THE GREATER PENINSULA AND WILL LOWER BARRIERS TO CREATE TRAUMA-INFORMED, CULTURALLY COMPETENT, SURVIVOR-CENTERED AND INFORMED, GAINFUL EMPLOYMENT AND PATHWAYS TO SELF-EMPLOYMENT FOR SURVIVORS.

SURVIVORS OF TORTURE, INTERNATIONAL WILL PROVIDE DIRECT SERVICES FOR THE REHABILITATION OF TORTURE SURVIVORS, INCLUDING

CONTINUUM OF CARE PROGRAM

SCHOOL-BASED PREVENTION, EDUCATION AND CRISIS INTERVENTION PROGRAM

5/5-THE PSYCHIATRIC GWAS CONSORTIUM: INTEGRATED & COORDINATED GWAS META-ANALYSES

REFUGEE INDIVIDUAL DEVELOPMENT ACCOUNTS (IDA) PROGRAM

THE LEGAL ASSISTANCE FOR VICTIMS (LAV) GRANT PROGRAM, AUTHORIZED BY 34 U.S.C. 20121, IS INTENDED TO INCREASE THE AVAILABILITY OF CIVIL AND CRIMINAL LEGAL ASSISTANCE NEEDED TO EFFECTIVELY AID VICTIMS (AGES 11 AND OLDER) OF DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, AND STALKING BY PROVIDING FUNDS FOR COMPREHENSIVE DIRECT LEGAL SERVICES TO VICTIMS IN LEGAL MATTERS RELATING TO OR ARISING OUT OF THAT ABUSE OR VIOLENCE. LEGAL ASSISTANCE INCLUDES ASSISTANCE TO VICTIMS OF DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, AND STALKING IN: A) FAMILY, TRIBAL, TERRITORIAL, IMMIGRATION, EMPLOYMENT, ADMINISTRATIVE AGENCY, HOUSING MATTERS, CAMPUS ADMINISTRATIVE, OR PROTECTION OR STAY AWAY ORDER PROCEEDINGS, AND OTHER SIMILAR MATTERS; B) CRIMINAL JUSTICE INVESTIGATIONS, PROSECUTIONS, AND POST-TRIAL MATTERS (INCLUDING SENTENCING, PAROLE, AND PROBATION) THAT IMPACT THE VICTIMS SAFETY AND PRIVACY; C) ALTERNATIVE DISPUTE RESOLUTION, RESTORATIVE PRACTICES, OR OTHER PROCESSES INTENDED TO PROMOTE VICTIM SAFETY, PRIVACY, AND AUTONOMY; AND D) POST-CONVICTION RELIEF PROCEEDINGS IN STATE, LOCAL, TRIBAL, OR TERRITORIAL COURT WHERE THE CONVICTION OF A VICTIM IS RELATED TO OR ARISING FROM DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, STALKING, OR SEX TRAFFICKING. 34 U.S.C. 12291(A)(24)(C). THROUGH THIS CONTINUATION LEGAL ASSISTANCE FOR VICTIMS PROJECT, ADVOCATES FOR IMMIGRANT SURVIVORS, IN PARTNERSHIP WITH DAYA, INC., WILL PROVIDE FULL LEGAL REPRESENTATION TO VICTIMS OF DOMESTIC VIOLENCE, DATING VIOLENCE, STALKING, OR SEXUAL ASSAULT IN GREATER HOUSTON, TEXAS. THE PROJECT WILL ADDRESS THE FOLLOWING STATUTORY CONSIDERATION: IMPROVE THE AVAILABILITY OF LEGAL SERVICES FOR SEXUAL ASSAULT SURVIVORS, BY FOCUSING 50 PERCENT OR MORE OF ITS GRANT ACTIVITIES ON SEXUAL ASSAULT LEGAL SERVICES. THIS AWARD IS A CONTINUATION OF 15JOVW-22-GG-00322-LEGA.

THE LEGAL ASSISTANCE FOR VICTIMS (LAV) GRANT PROGRAM, AUTHORIZED BY 34 U.S.C. 20121, IS INTENDED TO INCREASE THE AVAILABILITY OF CIVIL AND CRIMINAL LEGAL ASSISTANCE NEEDED TO EFFECTIVELY AID VICTIMS (AGES 11 AND OLDER) OF DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, AND STALKING BY PROVIDING FUNDS FOR COMPREHENSIVE DIRECT LEGAL SERVICES TO VICTIMS IN LEGAL MATTERS RELATING TO OR ARISING OUT OF THAT ABUSE OR VIOLENCE. LEGAL ASSISTANCE INCLUDES ASSISTANCE TO VICTIMS OF DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, AND STALKING IN: A) FAMILY, TRIBAL, TERRITORIAL, IMMIGRATION, EMPLOYMENT, ADMINISTRATIVE AGENCY, HOUSING MATTERS, CAMPUS ADMINISTRATIVE, OR PROTECTION OR STAY AWAY ORDER PROCEEDINGS, AND OTHER SIMILAR MATTERS; B) CRIMINAL JUSTICE INVESTIGATIONS, PROSECUTIONS, AND POST-TRIAL MATTERS (INCLUDING SENTENCING, PAROLE, AND PROBATION) THAT IMPACT THE VICTIMS SAFETY AND PRIVACY; C) ALTERNATIVE DISPUTE RESOLUTION, RESTORATIVE PRACTICES, OR OTHER PROCESSES INTENDED TO PROMOTE VICTIM SAFETY, PRIVACY, AND AUTONOMY; AND D) POST-CONVICTION RELIEF PROCEEDINGS IN STATE, LOCAL, TRIBAL, OR TERRITORIAL COURT WHERE THE CONVICTION OF A VICTIM IS RELATED TO OR ARISING FROM DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, STALKING, OR SEX TRAFFICKING. 34 U.S.C. 12291(A)(24)(C). THROUGH THIS CONTINUATION LEGAL ASSISTANCE FOR VICTIMS PROJECT, SURVIVOR RESOURCE NETWORK, INC, IN PARTNERSHIP WITH LEGAL AID SERVICES OF OKLAHOMA, INC., WILL PROVIDE COMPREHENSIVE CIVIL LEGAL SERVICES TO SURVIVORS OF DOMESTIC VIOLENCE, DATING VIOLENCE, STALKING, OR SEXUAL ASSAULT IN KAY AND NOBLE COUNTIES OF OKLAHOMA. THIS AWARD IS A CONTINUATION OF 15JOVW-21-GG-00390-LEGA.

YEAR FOUR FUNDS AUTHORIZED FOR THIS GRANTEE FOR FY 26

GRANTEE YEAR THREE FUNDING FOR SUICIDE PREVENTION GRANTS PROVIDED BY SSG FOX SPGP. SUICIDE PREVENTION GRANTS ARE AWARDED TO ELIGIBLE ENTITIES TO MEET THE NEEDS OF ELIGIBLE INDIVIDUALS AND THEIR FAMILIES THROUGH OUTREACH, PROVISION OR COORDINATION OF SUICIDE PREVENTION SERVICES, AND CONNECTION TO VA AND COMMUNITY RESOURCES AS DESCRIBED IN 38 CFR PART 78

TO ADDRESS THE CHALLENGES FARMERS AND RANCHERS IN PUERTO RICO FACE BY PROVIDING WORKSHOPS AND TRAINING IN FARM AND RANCH MANAGEMENT, AGRICULTURAL PRACTICES, BUSINESS AND FINANCIAL PLANNING, MARKETING STRATEGIES, AND ACCESS TO USDA GRANTS AND LOANS.

PURPOSE: THE CONTINUUM OF CARE (COC) PROGRAM IS DESIGNED TO PROMOTE COMMUNITY-WIDE COMMITMENT TO THE GOAL OF ENDING HOMELESSNESS; PROVIDE FUNDING FOR EFFORTS BY NONPROFIT PROVIDERS, STATES, AND LOCAL GOVERNMENTS TO QUICKLY HOUSE HOMELESS INDIVIDUALS AND FAMILIES WHILE MINIMIZING THE TRAUMA AND DISLOCATION CAUSED TO HOMELESS INDIVIDUALS, FAMILIES, AND COMMUNITIES BY HOMELESSNESS; PROMOTE ACCESS TO AND EFFECTIVE UTILIZATION OF MAINSTREAM PROGRAMS BY HOMELESS INDIVIDUALS AND FAMILIES; AND OPTIMIZE SELF-SUFFICIENCY AMONG INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS. THE MOST RECENT COC AWARD ANNOUNCEMENT LISTING AWARDS BY STATE AND COC IS ACCESSIBLE AT HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/COC/AWARDS. SELECT THE LINK UNDER THE FUNDING AND AWARD INFORMATION SECTION FOR THE APPROPRIATE FISCAL YEAR.; ACTIVITIES TO BE PERFORMED: CONTINUUM OF CARE PROGRAM FUNDS MAY BE USED TO PAY FOR THE ELIGIBLE COSTS USED TO ESTABLISH AND OPERATE PROJECTS UNDER FIVE PROGRAM COMPONENTS: (1) PERMANENT HOUSING, WHICH INCLUDES PERMANENT SUPPORTIVE HOUSING FOR PERSONS WITH DISABILITIES, AND RAPID REHOUSING; (2) TRANSITIONAL HOUSING; (3) SUPPORTIVE SERVICES ONLY; (4) HOMELESS MANAGEMENT INFORMATION SYSTEMS (HMIS), AND (5) IN SOME CASES, HOMELESSNESS PREVENTION. THIRTEEN TYPES OF ASSISTANCE MAY BE PROVIDED THROUGH THE CONTINUUM OF CARE (COC) PROGRAM: (1) COC PLANNING ACTIVITIES/COSTS FOR DESIGNING AND CARRYING OUT A COLLABORATIVE PROCESS FOR THE DEVELOPMENT OF AN APPLICATION TO HUD; (2) UNITED FUNDING AGENCY (UFA) COSTS FOR FISCAL CONTROL AND ACCOUNTING NECESSARY TO ASSURE THE PROPER DISBURSAL OF, AND ACCOUNTING FOR, FEDERAL FUNDS AWARDED TO SUBRECIPIENTS UNDER THE CONTINUUM OF CARE PROGRAM, (3) ACQUISITION OF REAL PROPERTY (INCLUDING STRUCTURES) FOR USE IN THE PROVISION OF HOUSING OR SUPPORTIVE SERVICES; (4) REHABILITATION OF STRUCTURES TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (5) NEW CONSTRUCTION, INCLUDING THE BUILDING OF A NEW STRUCTURE OR BUILDING AN ADDITION TO AN EXISTING STRUCTURE FOR USE AS SUPPORTIVE HOUSING; (6) LEASING OF A STRUCTURE OR STRUCTURES, OR PORTIONS THEREOF, TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (7) RENTAL ASSISTANCE, WHICH MAY BE SHORT-TERM, MEDIUM-TERM, OR LONG-TERM, AS WELL AS TENANT-BASED, PROJECT-BASED, OR SPONSOR-BASED, FOR TRANSITIONAL OR PERMANENT HOUSING; (8) SUPPORTIVE SERVICES TO ASSIST PROGRAM PARTICIPANTS OBTAIN AND MAINTAIN HOUSING; (9) OPERATING COSTS OF SUPPORTIVE HOUSING; (10) COSTS OF IMPLEMENTING AND OPERATING HMIS; (11) PROJECT ADMINISTRATIVE COSTS; (12) RELOCATION COSTS; AND (13) INDIRECT COSTS IN ACCORDANCE WITH 2 CFR PARTS 200, AS APPLICABLE. IN ADDITION TO USING GRANT FUNDS FOR THE ELIGIBLE COSTS DESCRIBED ABOVE, RECIPIENTS AND SUBRECIPIENTS IN CONTINUUMS OF CARE DESIGNATED AS HIGH PERFORMING COMMUNITIES MAY ALSO USE GRANT FUNDS TO PROVIDE HOUSING RELOCATION AND STABILIZATION SERVICES AND SHORT- AND/OR MEDIUM-TERM RENTAL ASSISTANCE TO INDIVIDUALS AND FAMILIES AT RISK OF HOMELESSNESS AS SET FORTH IN 24 CFR 576.103 AND 24 CFR 576.104, IF NECESSARY TO PREVENT THE INDIVIDUAL OR FAMILY FROM BECOMING HOMELESS. LIMITATION ON USE OF FUNDS: NO ASSISTANCE PROVIDED UNDER PROGRAM (OR ANY STATE OR LOCAL GOVERNMENT FUNDS USED TO SUPPLEMENT THIS ASSISTANCE) MAY BE USED TO REPLACE STATE OR LOCAL FUNDS PREVIOUSLY USED, OR DESIGNATED FOR USE, TO ASSIST HOMELESS PERSONS OR PERSONS AT-RISK OF HOMELESSNESS.; EXPECTED OUTCOMES: DECREASE IN THE NUMBER INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS, MORE SPECIFICALLY USING PERFORMANCE INDICATORS SUCH AS THE LENGTH OF TIME HOMELESS, RETURNS TO HOMELESSNESS OVER TIME, AND EXITS TO PERMANENT HOUSING. COC PERFORMANCE PROFILE REPORTS CAN BE FOUND AT HTTPS://WWW.HUDEXCHANGE.INFO/PROGRAMS/COC/COC-PERFORMANCE-PROFILE-REPORTS/.; INTENDED BENEFICIARIES: INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

A "LIP READING" CLICK DEVICE FOR DISABLED COMPUTER USERS

INTRARENAL OXYGENATION: AN EARLY MARKER FOR RISK OF DEVELOPING AKI

CONTINUUM OF CARE PROGRAM

NOVO-118 AS A THERAPEUTIC TO PROMOTE REMYELINATION IN IN VIVO MODELS OF MS

INSTITUT PASTEUR DE COTE DIVOIRE APPLICATION TO CDC RFA-GH15-1627 BUILDING AND STRENGTHENING PUBLIC HEALTH LABORATORY SYSTEMS, CAPACITY AND SECURITY

THE LEGAL ASSISTANCE FOR VICTIMS (LAV) GRANT PROGRAM, AUTHORIZED BY 34 U.S.C. 20121, IS INTENDED TO INCREASE THE AVAILABILITY OF CIVIL AND CRIMINAL LEGAL ASSISTANCE NEEDED TO EFFECTIVELY AID VICTIMS (AGES 11 AND OLDER) OF DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, AND STALKING BY PROVIDING FUNDS FOR COMPREHENSIVE DIRECT LEGAL SERVICES TO VICTIMS IN LEGAL MATTERS RELATING TO OR ARISING OUT OF THAT ABUSE OR VIOLENCE. LEGAL ASSISTANCE INCLUDES ASSISTANCE TO VICTIMS OF DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, AND STALKING IN: A) FAMILY, TRIBAL, TERRITORIAL, IMMIGRATION, EMPLOYMENT, ADMINISTRATIVE AGENCY, HOUSING MATTERS, CAMPUS ADMINISTRATIVE, OR PROTECTION OR STAY AWAY ORDER PROCEEDINGS, AND OTHER SIMILAR MATTERS; B) CRIMINAL JUSTICE INVESTIGATIONS, PROSECUTIONS, AND POST-TRIAL MATTERS (INCLUDING SENTENCING, PAROLE, AND PROBATION) THAT IMPACT THE VICTIMS SAFETY AND PRIVACY; C) ALTERNATIVE DISPUTE RESOLUTION, RESTORATIVE PRACTICES, OR OTHER PROCESSES INTENDED TO PROMOTE VICTIM SAFETY, PRIVACY, AND AUTONOMY; AND D) POST-CONVICTION RELIEF PROCEEDINGS IN STATE, LOCAL, TRIBAL, OR TERRITORIAL COURT WHERE THE CONVICTION OF A VICTIM IS RELATED TO OR ARISING FROM DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, STALKING, OR SEX TRAFFICKING. 34 U.S.C. 12291(A)(24)(C). THROUGH THIS NEW LEGAL ASSISTANCE FOR VICTIMS PROJECT, ST. LOUIS SURVIVORS LEGAL SUPPORT, INC. WILL PROVIDE COMPREHENSIVE LEGAL SERVICES FOR ORDERS OF PROTECTION AND CUSTODY CASES FOR VICTIMS AND SURVIVORS OF DOMESTIC VIOLENCE IN ST. LOUIS COUNTY, MISSOURI.

ASSESSMENT OF NOVO-118 AS A REGENERATIVE THERAPEUTIC IN ACUTE SPINAL CORD INJURY

THE RURAL DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, AND STALKING PROGRAM (RURAL PROGRAM) IS AUTHORIZED BY 34 U.S.C. 12341. RURAL PROGRAM FUNDS ARE USED TO SUPPORT PROGRAMS THAT: 1) IDENTIFY, ASSESS, AND APPROPRIATELY RESPOND TO CHILD, YOUTH, AND ADULT VICTIMS OF DOMESTIC VIOLENCE, SEXUAL ASSAULT, DATING VIOLENCE, AND STALKING IN RURAL COMMUNITIES; 2) ESTABLISH AND EXPAND VICTIM SERVICES IN RURAL COMMUNITIES TO CHILD, YOUTH, AND ADULT VICTIMS; 3) INCREASE THE SAFETY AND WELL-BEING OF WOMEN AND CHILDREN IN RURAL COMMUNITIES, BY (A) DEALING DIRECTLY AND IMMEDIATELY WITH DOMESTIC VIOLENCE, SEXUAL ASSAULT, DATING VIOLENCE, AND STALKING; AND (B) CREATING AND IMPLEMENTING STRATEGIES TO INCREASE AWARENESS AND PREVENT THESE CRIMES; AND 4) DEVELOP, EXPAND, IMPLEMENT, AND IMPROVE THE QUALITY OF SEXUAL ASSAULT FORENSIC MEDICAL EXAMINATION OR SEXUAL ASSAULT NURSE EXAMINER PROGRAMS. GRANTEES MUST USE AT LEAST ONE OF THE FOLLOWING STRATEGIES IN IMPLEMENTING THEIR PROJECTS: 1) IMPLEMENT, EXPAND, AND ESTABLISH COOPERATIVE EFFORTS AND PROJECTS AMONG LAW ENFORCEMENT OFFICERS, PROSECUTORS, VICTIM SERVICE PROVIDERS, AND OTHER RELATED PARTIES TO INVESTIGATE AND PROSECUTE INCIDENTS OF DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, AND STALKING; 2) PROVIDE TREATMENT, COUNSELING, ADVOCACY, LEGAL ASSISTANCE, AND OTHER LONG-TERM AND SHORT-TERM VICTIM AND POPULATION SPECIFIC SERVICES TO ADULT AND MINOR VICTIMS OF DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, AND STALKING IN RURAL COMMUNITIES; 3) WORK IN COOPERATION WITH THE COMMUNITY TO DEVELOP EDUCATION AND PREVENTION STRATEGIES DIRECTED TOWARD SUCH ISSUES; 4) DEVELOP, ENLARGE, OR STRENGTHEN PROGRAMS ADDRESSING SEXUAL ASSAULT; AND 5) DEVELOP PROGRAMS AND STRATEGIES THAT FOCUS ON THE SPECIFIC NEEDS OF VICTIMS OF WHO RESIDE IN REMOTE RURAL AND GEOGRAPHICALLY ISOLATED AREAS. THROUGH THIS NEW OVW RURAL PROGRAM PROJECT, RESPONSE, IN PARTNERSHIP WITH ASPEN FAMILY CONNECTIONS, WILL IMPLEMENT THE SURVIVOR SUPPORT SERVICES PROJECT. THIS VICTIM SERVICE AND OUTREACH PROJECT ADDRESSES THE FOLLOWING PURPOSE AREAS: 1, 2, AND 3 FOR PITKIN, EAGLE AND GARFIELD COUNTIES IN COLORADO. SPECIFIC ACTIVITIES WILL INCLUDE:1) FACILITATING A COMMUNITY RESPONSE TEAM TO IMPROVE COLLABORATIVE EFFORTS IN SERVING SURVIVORS; 2) ENSURING THAT ALL LOCAL LAW ENFORCEMENT AGENCIES ARE KNOWLEDGEABLE ABOUT RESPONSE AND SERVICES FOR SURVIVORS;3) PROVIDING ASSISTANCE FOR SURVIVORS INCLUDING HOUSING, FINANCIAL AND CIVIL LEGAL ASSISTANCE; 4) PROVIDING SOCIO-EMOTIONAL SUPPORTS FOR SURVIVORS, PARTICULARLY THOSE RECOVERING FROM SEXUAL ASSAULT; 5) PROVIDING CRISIS INTERVENTION FOR SURVIVORS; 6) INCREASING OUTREACH AND EDUCATION EFFORTS AROUND SEXUAL ASSAULT, DOMESTIC VIOLENCE, TEEN DATING VIOLENCE AND STALKING; AND 7) STRENGTHENING AWARENESS WITH PARTNER ORGANIZATIONS AND COMMUNITY STAKEHOLDERS TO INCREASE AWARENESS OF SERVICES FOR AND PREVENTION OF SEXUAL ASSAULT.

INTEGRATIVE ANALYSES OF CLINICAL PHARMACOGENETIC DATA TO PREVENT HOSPITAL READMISSION IN REAL-WORLD HEALTH SYSTEMS - PROJECT SUMMARY/ABSTRACT ADVERSE DRUG REACTIONS RELATED TO INADEQUATELY DOSED OR PRESCRIBED MEDICATIONS ARE A MAJOR CAUSE OF MORBIDITY, MORTALITY, AND HOSPITAL READMISSIONS IN THE UNITED STATES. PHARMACOGENETICS RESEARCH HAS IDENTIFIED GENETIC VARIANTS ASSOCIATED WITH RESPONSE OR TOXICITY FOR HUNDREDS OF DRUGS, AND VARIANT GENOTYPES CARRIED BY SOME INDIVIDUALS MAY CONTRIBUTE DISPROPORTIONATELY TO MEDICATION-RELATED HOSPITAL ADMISSIONS. YET THE CLINICAL UTILITY OF PHARMACOGENETICS (PGX) WHEN IMPLEMENTED IN HEALTHCARE SYSTEMS HAS NOT BEEN WIDELY ESTABLISHED. IN A RESOURCE-LIMITED HEALTH SYSTEM, IT IS NOT PRACTICAL TO GENOTYPE EVERY PATIENT, BUT IF WE CAN IDENTIFY PATIENTS AT HIGHER RISK OF HOSPITAL ADMISSION BASED ON MEDICATION PRESCRIBING EVENTS, WE COULD BE BETTER ABLE TO DISCERN WHICH PATIENTS TO APPROACH WITH PREEMPTIVE GENOTYPING. WE PROPOSE A COHORT STUDY WITHIN TWO LEARNING HEALTHCARE SYSTEMS WITH ESTABLISHED PGX IMPLEMENTATION PROGRAMS – NORTHSHORE UNIVERSITY HEALTHSYSTEM AND THE UNIVERSITY OF CHICAGO CENTER – IN A POOLED, ETHNICALLY DIVERSE PATIENT POPULATION OF 5,726 PATIENTS – TO EVALUATE THE AGGREGATE IMPACT OF PHARMACOGENETIC DRUG INTERACTIONS ON READMISSIONS AND EMERGENCY DEPARTMENT (ED) VISITS ATTRIBUTABLE TO ADVERSE DRUG REACTIONS INCLUDING INADEQUATE DRUG RESPONSE, OVER A TWO-YEAR FOLLOW-UP PERIOD. THE OVERALL GOAL OF THIS PROJECT IS TO DEVELOP NOVEL ANALYTIC METHODS TO QUANTIFY THE CONTRIBUTION OF GENE-X-DRUG INTERACTIONS AFTER HOSPITAL DISCHARGE TO ED VISITS AND READMISSIONS, AND TO IDENTIFY THOSE INDIVIDUALS AT GREATEST RISK OF THESE OUTCOMES. AIM 1 IS TO ESTIMATE THE RATE OF COMBINED 90-DAY ED VISITS AND READMISSIONS ATTRIBUTABLE TO INADEQUATE DRUG RESPONSE OR TOXICITY AND IDENTIFY THE CLINICAL AND DEMOGRAPHIC PREDICTORS OF THOSE ADMISSIONS. AIM 2 IS TO IDENTIFY 90-DAY ED VISITS AND READMISSIONS ASSOCIATED WITH ADVERSE DRUG REACTIONS AMONG PATIENTS DISCHARGED ON MEDICATIONS FOR WHICH THERE IS EVIDENCE OF GENETIC VARIABILITY FOR OUTCOMES – FOCUSING ON MEDICATIONS WITH HIGH-LEVEL EVIDENCE GUIDELINES FROM THE CLINICAL PHARMACOGENOMICS IMPLEMENTATION CONSORTIUM AND FOOD AND DRUG ADMINISTRATION LABELS PRESCRIBED AND CONTINUED AT HOSPITAL DISCHARGE ON 90-DAY READMISSIONS. AIM 3 WILL BE TO DETERMINE THE CONTRIBUTION OF SPECIFIC GENOTYPES TO MEDICATION-RELATED 90-DAY ED VISITS AND READMISSIONS VISITS AMONG GENOTYPED PATIENTS. THIS PROJECT IS RESPONSIVE TO RFA HG-20-037 ADVANCING GENOMIC MEDICINE RESEARCH BY FACILITATING ANALYSIS OF CLINICAL GENOMIC DATA AND WILL LEVERAGE THE EXTENSIVE EXPERIENCE OF OUR TEAM AND DATASET FROM TWO DIVERSE, REAL-WORLD HEALTHCARE SYSTEMS ACROSS CHICAGOLAND. OUR MULTIDISCIPLINARY, COLLABORATIVE TEAM, AIDED BY USE OF NATURAL LANGUAGE PROCESSING, WILL SCREEN ELECTRONIC HEALTH RECORDS TO EXTRACT DE-IDENTIFIED PATIENT DATA, CURATE, AND APPLY INNOVATIVE, INTEGRATED ANALYTIC METHODS TO BETTER IDENTIFY PATIENTS WHO COULD BENEFIT THE MOST FROM PREEMPTIVE PGX GENOTYPING AND PHARMACOVIGILANCE TO PREVENT ED VISITS AND READMISSIONS. IF, AS WE HYPOTHESIZE, OUR ANALYSES DEMONSTRATE THAT GENE-X-DRUG INTERACTIONS CONTRIBUTE SUBSTANTIALLY TO 90-DAY ED VISITS AND READMISSIONS, THESE METHODS CAN BE AUTOMATED AND WILL BE TRANSPORTABLE TO OTHER HEALTH SYSTEMS TO GUIDE PREEMPTIVE GENOTYPING PROTOCOLS FOR THE HIGHEST RISK PATIENTS TO PREVENT HOSPITAL READMISSIONS. THESE RESULTS WILL INFORM THE DESIGN OF A FUTURE CLINICAL EFFECTIVENESS TRIAL OF TAILORED, PGX INTERVENTIONS TO PREVENT ADVERSE DRUG REACTIONS AND ASSOCIATED READMISSIONS.

CONTINUUM OF CARE PROGRAM

PROSPECTIVE RCT OF OBSTRUCTED DEFECATION SURGERY: COMPARING TRANSVAGINAL RECTOPEXY, VENTRAL MESH RECTOPEXY AND POP REPAIR (PROD TRIAL) - OBSTRUCTED DEFECATION (OD), DEFINED AS INCOMPLETE EMPTYING OF STOOL, IS A WIDELY PREVALENT DISORDER IN WOMEN’S HEALTH AND RESULTING IN MAJOR QUALITY OF LIFE (QOL) AND HEALTHCARE BURDEN. SUCCESSFUL MANAGEMENT HAS BEEN IMPAIRED, HISTORICALLY, BY DEFICIENCIES RELATING TO BOTH DIAGNOSIS AND TREATMENT. FIRST, THERE HAS BEEN A PERSISTENT MISCONCEPTION THAT OD IN THE ABSENCE OF DYSSYNERGIA (I.E., UNCOORDINATED CONTRACTION OF PELVIC FLOOR) RESULTS FROM PROLAPSE OF THE POSTERIOR VAGINAL WALL (‘RECTOCELE’) AND IMPROVES AFTER ITS REPAIR. IN FACT, PRIOR STUDIES HAVE CONFIRMED THAT THIS FORM OF OD RESULTS FROM SUPPORT DEFECTS INVOLVING THE RECTUM RATHER THAN VAGINA (8-10), AND MOREOVER THAT RECTOCELE REPAIRS ARE UNRELIABLE IN RELIEVING OD SYMPTOMS. RECENT WORK FROM OUR CENTER CONFIRMED RECTAL DETACHMENT AND HYPERMOBILITY TO BE THE MAJOR DETERMINANTS OF OD IN THE IRRESPECTIVE OF THE PRESENCE OF A RECTOCELE. SECONDLY, TRADITIONAL DIAGNOSTIC MODALITIES TO ASSES RECTAL SUPPORT AS THE SOURCE OF OD ARE EXPENSIVE (E.G. MRI DEFECOGRAPHY) AND/OR INVASIVE (E.G. ANAL MANOMETRY), AND OFTEN GENERATE FINDINGS WITH UNCLEAR CLINICAL CORRELATION AND IMPACT ON CARE. FINALLY, AVAILABLE SURGERIES TO REPAIR RECTAL SUPPORT DEFECTS HAVE BEEN LIMITED TO INVASIVE TRANSABDOMINAL OR PERINEAL METHODS, TYPICALLY INVOLVING MESH IMPLANTATION AND RESERVED FOR SEVERE CASES, E.G. THOSE WITH OVERT RECTAL PROLAPSE. LAPAROSCOPIC OR OPEN VENTRAL MESH RECTOPEXY IS THE MOST WIDELY ACCEPTED OPERATION TO STABILIZE RECTAL SUPPORT. WE ARE TESTING THE HYPOTHESIS THAT OD SYMPTOMS IN THE ABSENCE OF DYSSYNERGIA PRIMARILY RESULT FROM DEFICIENCIES IN RECTAL SUPPORT AND THAT PATIENTS PRESENTING OD SYMPTOMS WITH OR WITHOUT VAGINAL PROLAPSE UNDERGOING OUR NEW DIAGNOSTIC EVALUATION AND SURGICAL TREATMENT WILL HAVE IMPROVED OUTCOMES RELATIVE TO THE CURRENT STANDARD OF CARE AT 2 YEARS AFTER SURGERY. OUR STUDY IS DESIGNED TO EVALUATE PRIMARY AND SECONDARY OUTCOMES RELATING TO THE TWO RECTOPEXY PROCEDURES ON OD AT 2 YEARS FOLLOW UP ACROSS TWO INSTITUTIONS. THIS CLINICAL DATA WILL BE COMPLEMENTED BY A COMPUTATIONAL MODELING APPROACH THAT AIMS TO PROVIDE INSIGHT INTO THE MOST LIKELY CONTRIBUTORS TO OD SYMPTOMS, I.E. VAGINAL VERSUS RECTAL SUPPORT DEFECTS. AIM 1: COMPARE OCCULT RECTAL HYPERMOBILITY AS MEASURED USING POSTERIOR COMPARTMENT DYNAMIC ULTRASOUND IMAGING VERSUS MR DEFECOGRAPHY. POSTERIOR COMPARTMENT DYNAMIC ULTRASOUND IS A NOVEL APPROACH FOR IDENTIFYING THE UNDERLYING ANATOMIC CAUSE OF OD IN WOMEN SUFFERING FROM OD SYMPTOMS WITHOUT COEXISTING FUNCTIONAL BOWEL DISORDERS (E.G. NORMAL BM FREQUENCY AND STOOL TYPE, AND ABSENCE OF DYSSYNERGIA). AIM 2: COMPARE ANATOMIC, FUNCTIONAL, AND HEALTH-RELATED QUALITY OF LIFE OUTCOMES IN FEMALE SUBJECTS WITH MODERATE TO SEVERE OD SYMPTOMS, AND RECTAL HYPERMOBILITY DIAGNOSED BY ULTRASOUND, WHO ARE RANDOMIZED TO MINIMALLY INVASIVE TRANSVAGINAL RECTOPEXY VERSUS ABDOMINAL VENTRAL RECTOPEXY AT 2 YEARS AFTER SURGERY. AIM 3: DEVELOP AND VALIDATE A COMPUTATIONAL FINITE ELEMENT MODEL AND STATISTICAL SHAPE MODELING APPROACH TO DESCRIBE THE MECHANICS OF NORMAL DEFECATION AND THE ROLE OF RECTAL AND VAGINAL SUPPORT DEFICIENCIES IN CAUSING OD SYMPTOMS.

TRANSITIONAL HOUSING PROGRAM

RAP AS A NOVEL THERAPEUTIC TO PROMOTE REMYELINATION AFTER MS DEMYELINATING EVENT

CONTINUUM OF CARE PROGRAM

STRENGTHEN PUBLIC HEALTH LABORATORY SYSTEMS FOR PRIORITY DISEASES, OUTBREAKS DETECTION, AND SURVEILLANCE IN COTE D?IVOIRE - STRENGTHEN PUBLIC HEALTH LABORATORY SYSTEMS FOR PRIORITY DISEASES, OUTBREAKS DETECTION, AND SURVEILLANCE IN COTE D’IVOIRE

MANY INDUSTRIES USE RAW MATERIALS OR PROCESSES THAT RESULT IN HIGH CONCENTRATIONS OF POLLUTANTS IN WASTEWATER. THESE POLLUTANTS CAN HAVE A WIDE RANGE OF DETRIMENTAL EFFECTS ON THE ENVIRONMENT AND HUMAN HEALTH. REGULATIONS ARE ESTABLISHED TO LIMIT THE AMOUNT OF POLLUTANTS THAT ARE RELEASED INTO THE ENVIRONMENT. ADDITIONALLY, RISING FRESH WATER COSTS AND OVERALL WATER SCARCITY IS DRIVING THE NEED FOR WATER REUSE AT INDUSTRIAL MANUFACTURING FACILITIES. THEREFORE, EFFICIENT WASTEWATER TREATMENT SYSTEMS ARE NEEDED TO MEET POLLUTANT REMOVAL TARGETS AT INDUSTRIAL AND MANUFACTURING FACILITIES. ADSORPTION IS THE MOST FAVORABLE METHOD USED TO REMOVE POLLUTANTS FROM WASTEWATER DUE TO ITS EFFICIENCY, HIGH ADSORPTION CAPACITY, AND LOW OPERATIONAL COST.IN THE PROPOSED PHASE II PROJECT, WORK WILL BE CONDUCTED TO SCALE UP AND OPTIMIZE THE COMPOSITE ADSORBENT MATERIAL FORMULATION AND FABRICATION PROCESS DEVELOPED IN PHASE I. A PILOT PRODUCTION SYSTEM WILL BE BUILT TO DEMONSTRATE THE CONCEPT AT A LARGER SCALE. FROM THE PILOT SCALE DATA, PERFORMANCE AND ECONOMIC EVALUATIONS WILL BE PERFORMED TO VERIFY THE ADVANTAGES OF THE PROPOSED ADSORBENTS OVER TRADITIONAL ADSORBENTS. THE SUCCESSFUL DEVELOPMENT OF PROPOSED COMPOSITE ADSORBENTS USING BIOMASS MATERIALS WILL INCREASE THE UTILIZATION OF WOODY RESOURCES FOR VALUE-ADDED PRODUCTS FROM WOOD AND OTHER AGRICULTURAL MATERIALS, IMPROVE WATER QUALITY AND CONSERVATION THROUGH EFFECTIVE WASTEWATER TREATMENT AND REUSE, AND REDUCE ENVIRONMENTAL IMPACTS OF BIOMASS WASTES.

LEUKOCYTIC PHENOTYPES ASSOCIATED WITH BPH PROGRESSION

SBIR PHASE II: AUTOLIGATION CHAIN REACTION: DNA AMPLIFICATION WITHOUT ENZYMES OR NUCLEOTIDES

PURPOSE: THE CONTINUUM OF CARE (COC) PROGRAM IS DESIGNED TO PROMOTE COMMUNITY-WIDE COMMITMENT TO THE GOAL OF ENDING HOMELESSNESS; PROVIDE FUNDING FOR EFFORTS BY NONPROFIT PROVIDERS, STATES, AND LOCAL GOVERNMENTS TO QUICKLY HOUSE HOMELESS INDIVIDUALS AND FAMILIES WHILE MINIMIZING THE TRAUMA AND DISLOCATION CAUSED TO HOMELESS INDIVIDUALS, FAMILIES, AND COMMUNITIES BY HOMELESSNESS; PROMOTE ACCESS TO AND EFFECTIVE UTILIZATION OF MAINSTREAM PROGRAMS BY HOMELESS INDIVIDUALS AND FAMILIES; AND OPTIMIZE SELF-SUFFICIENCY AMONG INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS. THE MOST RECENT COC AWARD ANNOUNCEMENT LISTING AWARDS BY STATE AND COC IS ACCESSIBLE AT HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/COC/AWARDS. SELECT THE LINK UNDER THE FUNDING AND AWARD INFORMATION SECTION FOR THE APPROPRIATE FISCAL YEAR.; ACTIVITIES TO BE PERFORMED: CONTINUUM OF CARE PROGRAM FUNDS MAY BE USED TO PAY FOR THE ELIGIBLE COSTS USED TO ESTABLISH AND OPERATE PROJECTS UNDER FIVE PROGRAM COMPONENTS: (1) PERMANENT HOUSING, WHICH INCLUDES PERMANENT SUPPORTIVE HOUSING FOR PERSONS WITH DISABILITIES, AND RAPID REHOUSING; (2) TRANSITIONAL HOUSING; (3) SUPPORTIVE SERVICES ONLY; (4) HOMELESS MANAGEMENT INFORMATION SYSTEMS (HMIS), AND (5) IN SOME CASES, HOMELESSNESS PREVENTION. THIRTEEN TYPES OF ASSISTANCE MAY BE PROVIDED THROUGH THE CONTINUUM OF CARE (COC) PROGRAM: (1) COC PLANNING ACTIVITIES/COSTS FOR DESIGNING AND CARRYING OUT A COLLABORATIVE PROCESS FOR THE DEVELOPMENT OF AN APPLICATION TO HUD; (2) UNITED FUNDING AGENCY (UFA) COSTS FOR FISCAL CONTROL AND ACCOUNTING NECESSARY TO ASSURE THE PROPER DISBURSAL OF, AND ACCOUNTING FOR, FEDERAL FUNDS AWARDED TO SUBRECIPIENTS UNDER THE CONTINUUM OF CARE PROGRAM, (3) ACQUISITION OF REAL PROPERTY (INCLUDING STRUCTURES) FOR USE IN THE PROVISION OF HOUSING OR SUPPORTIVE SERVICES; (4) REHABILITATION OF STRUCTURES TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (5) NEW CONSTRUCTION, INCLUDING THE BUILDING OF A NEW STRUCTURE OR BUILDING AN ADDITION TO AN EXISTING STRUCTURE FOR USE AS SUPPORTIVE HOUSING; (6) LEASING OF A STRUCTURE OR STRUCTURES, OR PORTIONS THEREOF, TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (7) RENTAL ASSISTANCE, WHICH MAY BE SHORT-TERM, MEDIUM-TERM, OR LONG-TERM, AS WELL AS TENANT-BASED, PROJECT-BASED, OR SPONSOR-BASED, FOR TRANSITIONAL OR PERMANENT HOUSING; (8) SUPPORTIVE SERVICES TO ASSIST PROGRAM PARTICIPANTS OBTAIN AND MAINTAIN HOUSING; (9) OPERATING COSTS OF SUPPORTIVE HOUSING; (10) COSTS OF IMPLEMENTING AND OPERATING HMIS; (11) PROJECT ADMINISTRATIVE COSTS; (12) RELOCATION COSTS; AND (13) INDIRECT COSTS IN ACCORDANCE WITH 2 CFR PARTS 200, AS APPLICABLE. IN ADDITION TO USING GRANT FUNDS FOR THE ELIGIBLE COSTS DESCRIBED ABOVE, RECIPIENTS AND SUBRECIPIENTS IN CONTINUUMS OF CARE DESIGNATED AS HIGH PERFORMING COMMUNITIES MAY ALSO USE GRANT FUNDS TO PROVIDE HOUSING RELOCATION AND STABILIZATION SERVICES AND SHORT- AND/OR MEDIUM-TERM RENTAL ASSISTANCE TO INDIVIDUALS AND FAMILIES AT RISK OF HOMELESSNESS AS SET FORTH IN 24 CFR 576.103 AND 24 CFR 576.104, IF NECESSARY TO PREVENT THE INDIVIDUAL OR FAMILY FROM BECOMING HOMELESS. LIMITATION ON USE OF FUNDS: NO ASSISTANCE PROVIDED UNDER PROGRAM (OR ANY STATE OR LOCAL GOVERNMENT FUNDS USED TO SUPPLEMENT THIS ASSISTANCE) MAY BE USED TO REPLACE STATE OR LOCAL FUNDS PREVIOUSLY USED, OR DESIGNATED FOR USE, TO ASSIST HOMELESS PERSONS OR PERSONS AT-RISK OF HOMELESSNESS.; EXPECTED OUTCOMES: DECREASE IN THE NUMBER INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS, MORE SPECIFICALLY USING PERFORMANCE INDICATORS SUCH AS THE LENGTH OF TIME HOMELESS, RETURNS TO HOMELESSNESS OVER TIME, AND EXITS TO PERMANENT HOUSING. COC PERFORMANCE PROFILE REPORTS CAN BE FOUND AT HTTPS://WWW.HUDEXCHANGE.INFO/PROGRAMS/COC/COC-PERFORMANCE-PROFILE-REPORTS/.; INTENDED BENEFICIARIES: INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

HOUSING STABILITY PROGRAM - DELAWARE

THE GRANTS FOR OUTREACH AND SERVICES TO UNDERSERVED POPULATIONS (UNDERSERVED PROGRAM) WAS STATUTORILY CREATED IN THE VIOLENCE AGAINST WOMEN REAUTHORIZATION ACT OF 2013 (VAWA 2013) TO DEVELOP AND IMPLEMENT OUTREACH STRATEGIES TARGETED AT ADULT OR YOUTH VICTIMS OF DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, OR STALKING IN UNDERSERVED POPULATIONS, AND TO PROVIDE VICTIM SERVICES TO MEET THE NEEDS OF SUCH POPULATIONS. GRANT FUNDS MAY BE USED TO: 1) WORK WITH FEDERAL, STATE, TRIBAL, TERRITORIAL, AND LOCAL GOVERNMENTS, AGENCIES, AND ORGANIZATIONS TO DEVELOP OR ENHANCE POPULATION SPECIFIC VICTIM SERVICES; 2) STRENGTHEN THE CAPACITY OF UNDERSERVED POPULATIONS TO PROVIDE POPULATION SPECIFIC VICTIM SERVICES; 3) STRENGTHEN THE CAPACITY OF TRADITIONAL VICTIM SERVICE PROVIDERS TO PROVIDE POPULATION SPECIFIC VICTIM SERVICES; 4) STRENGTHEN THE EFFECTIVENESS OF CRIMINAL AND CIVIL JUSTICE INTERVENTIONS BY PROVIDING TRAINING FOR LAW ENFORCEMENT, PROSECUTORS, JUDGES, AND OTHER COURT PERSONNEL ON DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, OR STALKING IN UNDERSERVED POPULATIONS; 5) WORK IN COOPERATION WITH AN UNDERSERVED POPULATION TO DEVELOP AND IMPLEMENT OUTREACH, EDUCATION, PREVENTION, AND INTERVENTION STRATEGIES THAT HIGHLIGHT AVAILABLE RESOURCES AND THE SPECIFIC ISSUES FACED BY VICTIMS OF DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, OR STALKING FROM UNDERSERVED POPULATIONS; OR, 6) STRENGTHEN THE RESPONSE OF SOCIAL AND HUMAN SERVICES BY PROVIDING POPULATION-SPECIFIC TRAINING FOR SERVICE PROVIDERS ON DOMESTIC VIOLENCE, DATING VIOLENCE SEXUAL ASSAULT, OR STALKING IN UNDERSERVED POPULATIONS. ELIGIBLE APPLICANTS ARE LIMITED TO: POPULATION SPECIFIC ORGANIZATIONS OR VICTIM SERVICE PROVIDERS THAT ARE (1) DEAF PROGRAMS (2) LESBIAN, GAY, BISEXUAL, AND TRANSGENDER (LGBT) ORGANIZATIONS, (3) ORGANIZATIONS SERVING UNDERSERVED RELIGIOUS POPULATIONS, (4) DISABILITY PROGRAMS, OR (5) ORGANIZATIONS SERVING CERTAIN UNDERSERVED RACIAL AND ETHNIC POPULATIONS. THE RESOURCE, EDUCATION, ALLIANCE, COMMUNITY BUILDING, HEALING (REACH) PROGRAM OF SURVIVORS PATHWAY CORPORATION JUSTICE AND EMPOWERMENT CENTER SPECIFICALLY WORKS WITH THE IMMIGRANT LATINX COMMUNITY IDENTIFYING AS LGBTQI+ IN MIAMI-DADE COUNTY TO REDUCE BARRIERS THAT KEEP THIS POPULATION FROM ACCESSING AND UTILIZING VICTIM SERVICES. TO ADDRESS THESE BARRIERS, REACH WILL DEVELOP AND DELIVER EDUCATIONAL RESOURCES TO EQUIP COMMUNITY PARTNERS, THE LOCAL POLICE DEPARTMENT, CLERGY, AND OTHER NONTRADITIONAL COMMUNITY PARTNERS WITH VICTIM SERVICE INFORMATION, HOW TO SCREEN FOR SEXUAL AND DOMESTIC VIOLENCE, AND BEST PRACTICES FOR A TRAUMA-INFORMED APPROACH TO SERVING LGBTQI+ SURVIVORS OF VIOLENCE. REACH WILL PRODUCE A SOCIAL MEDIA CAMPAIGN TO DISMANTLE FEAR AND ENCOURAGE INDIVIDUALS TO ACCESS SERVICES. INDIVIDUALS THAT CONTACT REACH, ONLINE OR IN PERSON, SEEKING SERVICES WILL BE ASSIGNED TO EITHER A DIGITAL OR IN-PERSON ADVOCATE TO ASSIST. ALL PLANNED SERVICES WILL BE AVAILABLE IN PERSON OR ONLINE, AS WELL AS IN ENGLISH AND SPANISH TO PROMOTE ACCESSIBILITY.

THE GRANTS FOR OUTREACH AND SERVICES TO UNDERSERVED POPULATIONS (UNDERSERVED PROGRAM) WAS STATUTORILY CREATED IN THE VIOLENCE AGAINST WOMEN REAUTHORIZATION ACT OF 2013 TO DEVELOP AND IMPLEMENT OUTREACH STRATEGIES TARGETED AT ADULT OR YOUTH VICTIMS OF DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, OR STALKING IN UNDERSERVED POPULATIONS, AND TO PROVIDE VICTIM SERVICES TO MEET THE NEEDS OF SUCH POPULATIONS. GRANT FUNDS MAY BE USED TO: 1) WORK WITH FEDERAL, STATE, TRIBAL, TERRITORIAL, AND LOCAL GOVERNMENTS, AGENCIES, AND ORGANIZATIONS TO DEVELOP OR ENHANCE POPULATION SPECIFIC VICTIM SERVICES; 2) STRENGTHEN THE CAPACITY OF UNDERSERVED POPULATIONS TO PROVIDE POPULATION SPECIFIC VICTIM SERVICES; 3) STRENGTHEN THE CAPACITY OF TRADITIONAL VICTIM SERVICE PROVIDERS TO PROVIDE POPULATION SPECIFIC VICTIM SERVICES; 4) STRENGTHEN THE EFFECTIVENESS OF CRIMINAL AND CIVIL JUSTICE INTERVENTIONS BY PROVIDING TRAINING FOR LAW ENFORCEMENT, PROSECUTORS, JUDGES, AND OTHER COURT PERSONNEL ON DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, OR STALKING IN UNDERSERVED POPULATIONS; 5) WORK IN COOPERATION WITH AN UNDERSERVED POPULATION TO DEVELOP AND IMPLEMENT OUTREACH, EDUCATION, PREVENTION, AND INTERVENTION STRATEGIES THAT HIGHLIGHT AVAILABLE RESOURCES AND THE SPECIFIC ISSUES FACED BY VICTIMS OF DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, OR STALKING FROM UNDERSERVED POPULATIONS; OR (6) PROVIDE POPULATION-SPECIFIC TRAINING FOR SOCIAL AND HUMAN SERVICES PROVIDERS ON DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, OR STALKING IN UNDERSERVED POPULATIONS. OUR DEAF SURVIVORS CENTER, IN COLLABORATION WITH THE MASSACHUSETTS COMMISSION FOR DEAF AND HARD OF HEARING (MCDHH), WILL IMPLEMENT THE FILLING IN THE GAPS FOR DEAF SURVIVORS OF DOMESTIC VIOLENCE PROJECT. THROUGH THIS NEW AWARD, THE PROJECT WILL: 1) SUPPORT A NEW VICTIM ADVOCATE; 2) PROVIDE LIFE SKILLS AND OTHER SERVICES THAT SUPPORT VICTIM EMPOWERMENT AND SELF-SUFFICIENCY; 3) EXPAND SERVICES FOR DEAF SURVIVORS THROUGHOUT RURAL WESTERN MASSACHUSETTS; 4) DELIVER EDUCATION AND TRAININGS TO OTHER PROVIDERS ON HOW TO PROVIDE CULTURALLY AND LINGUISTICALLY APPROPRIATE SERVICES FOR DEAF VICTIMS OF DOMESTIC VIOLENCE; AND 5) COLLABORATE WITH PARTNERS TO EXPAND HEALTHY RELATIONSHIP SUPPORT GROUPS TO FOUR NEW LOCATIONS.

THE LEGAL ASSISTANCE FOR VICTIMS (LAV) GRANT (LAV) PROGRAM, AUTHORIZED BY 34 U.S.C. § 20121, INCREASES THE AVAILABILITY OF CIVIL AND CRIMINAL LEGAL ASSISTANCE FOR ADULT AND YOUTH VICTIMS OF DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, AND STALKING BY PROVIDING FUNDS FOR COMPREHENSIVE DIRECT LEGAL SERVICES TO VICTIMS IN LEGAL MATTERS RELATING TO OR ARISING OUT OF THAT ABUSE OR VIOLENCE. “LEGAL ASSISTANCE” INCLUDES ASSISTANCE IN: A) FAMILY, TRIBAL, TERRITORIAL, IMMIGRATION, EMPLOYMENT, ADMINISTRATIVE AGENCY, HOUSING MATTERS, CAMPUS ADMINISTRATIVE, OR PROTECTION OR STAY AWAY ORDER PROCEEDINGS, AND OTHER SIMILAR MATTERS; AND B) CRIMINAL JUSTICE INVESTIGATIONS, PROSECUTIONS, AND POST-TRIAL MATTERS (E.G., SENTENCING, PAROLE, AND PROBATION) THAT IMPACT THE VICTIM’S SAFETY AND PRIVACY. LAV FUNDS PROJECTS THAT IMPLEMENT, EXPAND, AND/OR ESTABLISH THIS COMPREHENSIVE LEGAL ASSISTANCE THROUGH (1) COLLABORATIONS BETWEEN LEGAL ASSISTANCE PROVIDERS AND DOMESTIC VIOLENCE, DATING VIOLENCE, AND SEXUAL ASSAULT VICTIM SERVICE PROVIDERS; (2) EFFORTS BY ORGANIZATIONS WITH A DEMONSTRATED HISTORY OF PROVIDING DIRECT LEGAL OR ADVOCACY SERVICES ON BEHALF OF VICTIMS OF DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, AND STALKING; OR (3) COMPETENT SUPERVISED PRO BONO LEGAL ASSISTANCE. GRANTEES MUST EITHER DEMONSTRATE EXPERTISE ON DOMESTIC VIOLENCE, DATING VIOLENCE, SEXUAL ASSAULT, AND/OR STALKING, OR PARTNER WITH AN ORGANIZATION THAT HAS SUCH EXPERTISE. THE TIMING FOR PERFORMANCE OF THIS AWARD IS 36 MONTHS.

KAY COUNTY LEGAL ASSISTANCE FOR VICTIMS PROJECT

SBIR PHASE II: GRAPHENE CONDUCTIVE INKS FOR FLEXIBLE PRINTED ELECTRONICS

SAKHI FOR SOUTH ASIAN WOMEN'S DIRECT SERVICES PROGRAM ECONOMIC EMPOWERMENT PROGRAM AND COMMUNITY OUTREACH PROGRAM.

SAKHI FOR SOUTH ASIAN WOMEN'S SEXUAL ASSAULT PROGRAM

INDOOR NAVIGATION AID FOR BLIND AND VISUALLY-IMPAIRED INDIVIDUALS IN UNFAMILIAR SPACES

ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING, AND MISCELLANEOUS GRANTS

CONTINUUM OF CARE PROGRAM

THE SSVF PROGRAM'S PURPOSE IS TO PROVIDE SUPPORTIVE SERVICES GRANTS TO PRIVATE NON-PROFIT ORGANIZATIONS AND CONSUMER COOPERATIVES, WHO WILL COORDINATE OR PROVIDE SUPPORTIVE SERVICES TO VERY LOW-INCOME VETERAN FAMILIES WHO ARE RESIDING IN PERMANENT HOUSING, ARE HOMELESS AND SCHEDULED TO BECOME RESIDENTS OF PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD; OR AFTER EXITING PERMANENT HOUSING WITHIN A SPECIFIED TIME PERIOD, ARE SEEKING OTHER HOUSING THAT IS RESPONSIVE TO SUCH VERY LOW-INCOME VETERAN FAMILY'S NEEDS AND PREFERENCES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES. GRANTEES WILL USE SUPPORTIVE SERVICES GRANT FUNDS TO PROVIDE SUPPORTIVE SERVICE. ALL GRANTEES ARE REQUIRED TO PROVIDE OUTREACH SERVICES, CASE MANAGEMENT SERVICES, ASSISTANCE IN OBTAINING VA BENEFITS AND ASSISTANCE IN OBTAINING AND COORDINATING OTHER PUBLIC BENEFITS. IN ADDITION TO THE REQUIRED SERVICES, GRANTEES MAY ALSO PROVIDE TEMPORARY FINANCIAL ASSISTANCE PAID DIRECTLY TO A THIRD PARTY ON BEHALF OF A PARTICIPANT FOR CHILD CARE, EMERGENCY HOUSING ASSISTANCE, TRANSPORTATION, RENTAL ASSISTANCE, UTILITY-FEE PAYMENT ASSISTANCE, SECURITY DEPOSITS, UTILITY DEPOSITS, MOVING COSTS, AND GENERAL HOUSING STABILITY ASSISTANCE (WHICH INCLUDES EMERGENCY SUPPLIES), IN ACCORDANCE WITH 38 CFR PART 62. ADDITIONAL OPTIONAL SUPPORTIVE SERVICES MAY INCLUDE LEGAL ASSISTANCE AND FINANCIAL MANAGEMENT SERVICES.

CONTINUUM OF CARE PROGRAM