Madonna Inc

HIGHER EDUCATION EMERGENCY RELIEF FUND-IHE/INSTITUTION

INSTITUTION’S 50% DIRECT-TO-STUDENT ALLOCATION ON THE CERTIFICATE

STRENGTHENING INSTITUTIONS

ENGLISH LANGUAGE ACQUISITION: NATIONAL PROFESSIONAL DEVELOPMENT PROGRAM

STUDENT SUPPORT SERVICES PROGRAM

MADONNA UNIVERSITY TRIO STUDENT SUPPORT SERVICES GRANT

STUDENT SUPPORT SERVICES PROGRAM

TRIO - STUDENT SUPPORT SERVICES - STUDENT SUPPORT SERVICES PROGRAM

QUANTITATIVE MODELING SOFTWARE WITH APPLICATIONS TO MEDICAL DECISION MAKING - PROJECT SUMMARY/ABSTRACT IN RECENT YEARS, HEALTH CARE SYSTEMS AND PHYSICIANS HAVE MADE CONCERTED EFFORTS TO PRACTICE EVIDENCE-BASED MEDICINE AND PROVIDE PATIENTS WITH THE BEST AVAILABLE INFORMATION WHEN MAKING CHOICES ABOUT THEIR MEDICAL CARE. HOWEVER, MEDICAL DECISIONS ARE OFTEN COMPLEX WITH MANY UNCERTAINTIES AND POTENTIAL OUTCOMES TO CONSIDER, SOME BENEFICIAL AND SOME ADVERSE. A POPULAR ANALYTIC METHOD USED TO HELP IDENTIFY BEST TREATMENT STRATEGIES WHILE ACCOUNTING FOR UNCERTAINTY IS DECISION ANALYSIS, WHICH TYPICALLY INVOLVES COMPUTER MODELING OF A TREATMENT CHOICE OUTLINED IN THE FORM OF A DECISION TREE, WHICH SHOWS OPTIONS AND HEALTH OUTCOMES THAT MAY OCCUR AS A RESULT OF THE CHOICE MADE. COMPLEX DECISION TREES ARE EVALUATED VIA MONTE CARLO MICROSIMULATION TO ALLOW FOR VARIABILITY IN INDIVIDUAL PATIENT CHARACTERISTICS AND TRACE A PATIENT’S PATH THROUGH THE TREE; WHEN THE MICROSIMULATION IS REPEATED MANY TIMES TO SIMULATE MANY INDIVIDUALS, IT PROVIDES THE PROBABILITY OF EACH POTENTIAL OUTCOME RESULTING FROM THE INITIAL DECISION. FROM THIS PROBABILITY DISTRIBUTION, QUANTITATIVE MEASURES ASSOCIATED WITH EACH DECISION CAN BE CALCULATED SUCH AS LIFE YEARS, QUALITY-ADJUSTED LIFE YEARS (A GENERIC MEASURE OF DISEASE BURDEN), AND OTHERS; FURTHERMORE, WHEN COSTS ARE ALSO INCORPORATED, COST-EFFECTIVENESS ANALYSIS (CEA) CAN BE PERFORMED TO COMPUTE THE INCREMENTAL COST-EFFECTIVENESS OF EACH OPTION. IN THIS PROPOSAL, WE DESCRIBE PLANS TO ADD FUNCTIONALITY TO THE MATHEMATICAL MODELING SOFTWARE BERKELEY MADONNA TO ALLOW USERS TO BUILD DECISION TREES AND CARRY OUT MONTE CARLO MICROSIMULATIONS AND MARKOV COHORT ANALYSIS. BERKELEY MADONNA’S INTERFACE WAS DESIGNED TO MAKE MATHEMATICAL MODELING QUICK AND EASY FOR NON-TECHNICAL USERS BY USING A SIMPLE SYNTAX AND GRAPHICAL IMAGES TO CONSTRUCT SOPHISTICATED DIFFERENTIAL EQUATIONS. WE WILL LEVERAGE THIS EASY-TO-USE INTERFACE TO ENABLE MEDICAL RESEARCHERS TO PERFORM MICROSIMULATION WITH SOFTWARE THAT IS MORE USER-FRIENDLY, TRANSPARENT, POWERFUL, AND AFFORDABLE THAN CURRENTLY AVAILABLE OPTIONS. IN AIM 1, WE PROPOSE FURTHER DEVELOPMENT OF OUR DECISION ANALYSIS USER INTERFACE THAT ALLOWS USERS TO GRAPHICALLY CONSTRUCT DECISION TREES AND PERFORM MICROSIMULATIONS. IN THIS AIM, IN ADDITION TO OPTIMIZING TOOLS AND FEATURES FOR THE GUI, WE WILL ADD CEA OUTPUT REPORTS AND GRAPHICS, SENSITIVITY ANALYSIS CAPABILITIES, AND MARKOV COHORT ANALYSIS CAPABILITIES. WE WILL CREATE TUTORIALS AND A USER GUIDE AS WELL AS READY-MADE TEMPLATES THAT PROVIDE USERS A JUMPING OFF POINT FOR QUICKLY MAKING THEIR OWN MODELS. IN AIM 2, WE PROPOSE TO OPTIMIZE CODE FOR PERFORMANCE ON SINGLE CPUS, MULTIPLE CPUS, AND GPUS. ANALYSIS SPEED IS IMPORTANT BECAUSE LARGE, COMPLEX MODELS CAN TAKE WEEKS TO MONTHS TO RUN WITH CURRENTLY AVAILABLE SOFTWARE, NONE OF WHICH HARNESS THE POWER OF GPU TECHNOLOGY; SUCCESSFUL COMPLETION OF THIS AIM WOULD MAKE BERKELEY MADONNA THE FASTEST AVAILABLE SOFTWARE BY FAR FOR PERFORMING DECISION ANALYSIS MICROSIMULATIONS. FINALLY, WE WILL CARRY OUT EXTENSIVE BETA TESTING. ACHIEVEMENT OF THESE GOALS WILL PROVIDE AN EASY-TO-USE, TRANSPARENT, POWERFUL, AND AFFORDABLE TOOL TO BIOMEDICAL RESEARCHERS, EDUCATORS, AND PROFESSIONALS, AND POSITIVELY IMPACT SCIENTIFIC DISCOVERY.

ADVANCED EDUCATION NURSING GRANTS

RESEARCH FOCUSED INITIATIVE

LONG-TERM APPROACHES TO TREATING OSTEOPOROSIS - PROJECT SUMMARY/ABSTRACT OSTEOPOROSIS, A SKELETAL DISEASE CHARACTERIZED BY COMPROMISED BONE STRENGTH AND INCREASED RISK OF FRACTURE, AFFECTS 10 MILLION OLDER ADULTS IN THE UNITED STATES. APPROXIMATELY 50% OF POSTMENOPAUSAL WOMEN AND 25% OF WHITE MEN OVER AGE 60 WILL EXPERIENCE AN OSTEOPOROTIC FRACTURE IN THEIR LIFETIMES, AND THE MORBIDITY, MORTALITY, AND COSTS ARE HIGH AND PROJECTED TO INCREASE WITH THE AGING OF THE U.S. POPULATION. THERE ARE MANY EFFECTIVE PHARMACOLOGICAL TREATMENT OPTIONS FOR OSTEOPOROSIS, WHICH BROADLY FALL INTO CATEGORIES OF ANTIRESORPTIVE AGENTS THAT INHIBIT BONE BREAKDOWN AND ANABOLIC AGENTS THAT BUILD BONE. HOWEVER, INDIVIDUAL OSTEOPOROSIS THERAPIES ARE NOT RECOMMENDED FOR INDEFINITE USE, ALTHOUGH OSTEOPOROSIS IS A CHRONIC DISEASE THAT REQUIRES LONG-TERM MANAGEMENT TO MAINTAIN REDUCED RISK OF FRAGILITY FRACTURE. THUS, TREATMENT OF OSTEOPOROSIS OVER THE LIFETIME INVOLVES TRANSITIONS BETWEEN AGENTS. SEQUENTIAL USE OF OSTEOPOROSIS MEDICATIONS IS A NOVEL AND IMPORTANT AREA OF INVESTIGATION THAT REQUIRES FURTHER EXAMINATION. ADDITIONALLY, THE USE OF COMBINATION TREATMENT REGIMENS WITH MULTIPLE MEDICATIONS IS ANOTHER IMPORTANT TOPIC OF INTEREST THAT MAY BE EFFECTIVE AND APPROPRIATE SHORT-TERM THERAPY FOR SOME INDIVIDUALS WITH OSTEOPOROSIS AT PARTICULARLY HIGH FRACTURE RISK. CURRENTLY, THERE IS LITTLE SCIENTIFIC EVIDENCE TO GUIDE PHYSICIANS AND PATIENTS WITH OSTEOPOROSIS ON BEST STRATEGIES FOR TRANSITIONS BETWEEN MEDICATIONS FOR LONG-TERM TREATMENT, AND THIS HAS BEEN IDENTIFIED AS A KEY KNOWLEDGE GAP IN THE FIELD BY PROFESSIONAL SOCIETIES AND THE NIH. WITH THE WORK PROPOSED IN THIS APPLICATION WE AIM TO ADDRESS THIS KNOWLEDGE GAP BY EVALUATING MANY DIFFERENT LONG-TERM TREATMENT STRATEGIES FOR OSTEOPOROSIS, INCLUDING SEQUENTIAL AND COMBINATION THERAPIES, TO IDENTIFY THE BEST THERAPEUTIC APPROACHES OVER THE LIFETIME. TO DO SO, WE PROPOSE TO FIRST PERFORM META-ANALYSES OF CLINICAL STUDIES ON THE EFFICACY OF SEQUENTIAL AND COMBINATION THERAPIES FOR OSTEOPOROSIS (AIM 1). SUBSEQUENTLY, WE WILL PERFORM COMPREHENSIVE COST-EFFECTIVENESS ANALYSES COMPARING VARIOUS LONG-TERM TREATMENT STRATEGIES, INCLUDING SEQUENTIAL AND COMBINATION THERAPY REGIMENS, AS WELL AS THE USE OF SINGLE THERAPEUTIC AGENTS WITH INTERMITTENT DRUG HOLIDAYS, EXERCISE THERAPY, AND USUAL CARE (CALCIUM AND VITAMIN D ONLY) FOR PATIENTS WITH OSTEOPOROSIS AND DIFFERENT CLINICAL CHARACTERISTICS (AIM 2). OUR RESEARCH FINDINGS WILL ELUCIDATE WHICH OSTEOPOROSIS TREATMENT STRATEGIES ARE MOST EFFECTIVE AND COST-EFFECTIVE FOR INDIVIDUALS WITH VARIOUS CLINICAL CHARACTERISTICS OVER THE LIFETIME, AND THUS DIRECTLY ADDRESS ONE OF THE BIGGEST CHALLENGES FACING PHYSICIANS WHO TREAT PATIENTS WITH OSTEOPOROSIS. THIS INNOVATIVE INVESTIGATION WILL HELP PROVIDE THE FRAMEWORK FOR EVIDENCE- BASED AND INDIVIDUALIZED MANAGEMENT OF TRANSITIONS OF THERAPY FOR MILLIONS OF AMERICANS WITH OSTEOPOROSIS.

DISABILITY AND REHABILITATION RESEARCH PROJECTS

MULTIFAMILY HOUSING SERVICE COORDINATORS

PEDIATRIC INTELLIGENTLY CONTROLLED ASSISTIVE REHABILITATION ELLIPTICAL TRAINING SYSTEM TO PROMOTE FITNESS IN CHILDREN W/PHYSICAL LIMITATIONS

QUANTITATIVE MODELING SOFTWARE WITH APPLICATIONS TO MEDICAL DECISION MAKING

MADONNA UNIVERSITY CRUSADERS CARE (CREATING A RESPECTFUL ENVIRONMENT) DOJ GRANT

MADONNA UNIVERSITY TRIO STUDENT SUPPORT SERVICES GRANT FY 2025

FIELD INITIATED

DIRECTED GRANTS

ASSESSING METHODS TO ENHANCE AND PRESERVE PROTEINACEOUS IMPRESSIONS FROM THE SKIN OF DECEDENTS DURING THE EARLY STAGES OF DECOMPOSITION WHILE EXAMINING ENVIRONMENTAL VARIATIONS ACROSS SEASONS

DEVELOPING DNA FRIENDLY FLUOROGENIC METHODS FOR DETECTING, ENHANCING AND PRESERVING BLOODY AND PROTEINACEOUS IMPRESSION EVIDENCE

NURSE FACULTY LOAN PROGRAM

MULTIFAMILY HOUSING SERVICE COORDINATORS

COMPUTER-BASED SPEECH PRACTICE FOR DYSARTHRIA: A PRELIMINARY INVESTIGATION

UNS: COLLABORATIVE RESEARCH: PROSODIC CONTROL OF SPEECH SYNTHESIS FOR ASSISTIVE COMMUNICATION IN SEVERE PARALYSIS

MADONNA UNIVERSITY FULBRIGHT-HAYES GROUP PROJECT ABROAD (GPA)

NURSE FACULTY LOAN PROGRAM

NURSE FACULTY LOAN PROGRAM

MULTIFAMILY HOUSING SERVICE COORDINATORS

NURSE FACULTY LOAN PROGRAM

ADVANCED EDUCATION NURSING TRAINEESHIP

NURSE FACULTY LOAN PROGRAM

TO SUPPORT "PROJECT ACCESSIBLE HOLLYWOOD: MOTOWN," A FILM WORKSHOP FOR YOUTH AND COMMUNITY FESTIVAL DESIGNED TO INSPIRE AND RECORD THE STORIES OF STU

MULTIFAMILY HOUSING SERVICE COORDINATORS

HOMELESS ASSISTANCE