H Foundation

PHFE CDPH ELC 2019-2024

MANAGEMENT AND OPERATIONS OF THE JOIDES RESOLUTION AS A FACILITY FOR THE INTERNATIONAL OCEAN DISCOVERY PROGRAM (IODP)

ECOG-ACRIN NCORP RESEARCH BASE

TAS::97 0400::TAS INTEGRATED PHOTONICS IMI

ECOG-ACRIN OPERATIONS CENTER

COLLABORATIVE STUDY ON THE GENETICS OF ALCOHOLISM/COGA

AMERICAN INSTITUTE FOR MANUFACTURING INTEGRATED PHOTONICS 2.0

FORMER WORKER SURVEILLANCE PROGRAM

NYS OASAS SOR 3 - NEW YORK PROPOSES TO CONTINUE INVESTING IN REGIONAL NETWORKS TO BUILD CROSS-SYSTEM COLLABORATION AND INCREASE CONNECTIONS TO CARE. NEW YORK FUNDED REGIONAL NETWORKS THROUGH SOR 2 TO PROVIDE SERVICES ACROSS THE CONTINUUM OF CARE TO CREATE A WHOLISTIC APPROACH TO COMMUNITY INTERVENTION AT THE REGIONAL LEVEL. THIS INCLUDED UTILIZING MEASURES TO ENCOURAGE NETWORK AND PROVIDER COLLABORATION TO ATTAIN FURTHER INCREASES IN MAT INITIATION, MAT ADHERENCE, CONTINUATION OF ENGAGEMENT IN TREATMENT, AND CONTINUITY BETWEEN LEVELS OF CARE, AS WELL AS DEMONSTRABLY IMPROVED OUTREACH TO PEOPLE WHO USE OPIOIDS AND/OR STIMULANTS WHO ARE NOT ENGAGED IN CARE. THE NETWORKS INCORPORATED THE FULL CONTINUUM OF OASAS SERVICES INCLUDING PREVENTION AND RECOVERY INTO THE NETWORK AND INCLUDED A REPRESENTATIVE FROM EACH ON THE LEADERSHIP TEAM. EACH NETWORK WAS ENCOURAGED TO INCLUDE A FULL ARRAY OF SUD SERVICES INCLUDING HARM REDUCTION, CRISIS SERVICES, AND EVIDENCE-BASED PREVENTION PRACTICES. EACH OF THE NETWORKS HAS HAD SUCCESS IN BRINGING PROVIDERS TOGETHER, IMPLEMENTING SCOPES OF WORK AS PROPOSED IN THEIR APPLICATION, AND SOLVING PROBLEMS RELATED TO GAPS AND BARRIERS TO CARE IN THEIR COMMUNITIES. AN EXAMPLE OF THIS IS THE RECENT OPPORTUNITY THROUGH ANOTHER FUNDING SOURCE TO IMPLEMENT TRANSPORTATION WITHIN THE REGION FOR NON-MEDICAL SERVICES TO SUPPORT RECOVERY. EACH OF THE NETWORKS APPLIED FOR THE FUNDING WITH UNIQUE SOLUTIONS BASED ON THE NEEDS OF THEIR REGION CAPITALIZING ON THE COLLABORATION OF THE NETWORK AND THE CURRENT SUD ASSETS IN THE REGION. THROUGH A REQUEST FOR APPLICATIONS, EACH REGIONAL NETWORK WILL IDENTIFY THE INNOVATIVE MODELS OF SERVICE PROVISION IN PREVENTION, TREATMENT, AND RECOVERY THAT ADDRESS THE EXISTING NEEDS OF THEIR POPULATION. OASAS WILL PROVIDE A LIST OF SERVICES WHICH THE REGIONAL NETWORK WILL SELECT FROM TO BEST ADDRESS LOCAL NEEDS. AMONG THESE SERVICES, OASAS WILL PLACE AN EMPHASIS ON IN-COMMUNITY SERVICES AS MODELED IN THE CENTER OF TREATMENT INNOVATION (COTI) PROGRAM INITIATED UNDER STR AND CONTINUED THROUGH THE SOR GRANT. THE MODEL INCLUDES TRANSPORTATION AND MOBILE TREATMENT, THE USE OF A PEER OUTREACH WORKFORCE, TELE-PRACTICE AND LINKAGES MENTAL HEALTH AND MEDICAL SERVICES. OTHER MODELS AND TYPES OF SERVICE THE NETWORKS WILL INCLUDE ARE: LINKING EMERGENCY ROOMS TO PEERS, OUTPATIENT TREATMENT PROGRAMS, AND ADDICTION MEDICINE SPECIALISTS TO IMPROVE INTERVENTION AND INITIATION OF MEDICATION FOR OPIOID USE DISORDER; LINKING OUTPATIENT TREATMENT PROVIDERS TO FEDERALLY QUALIFIED HEALTH CENTERS; IMPROVE PROVIDER CAPACITY TO USE QUALITY IMPROVEMENT STRATEGIES TO INCREASE ACCESS TO MAT INITIATION, MAT ADHERENCE AND IMPROVED RATES OF FOLLOW UP AFTER HIGH INTENSITY SERVICES; IMPROVE SUD PROVIDER NETWORK COLLABORATION FOR SHARED AND AGGREGATED DATA ACROSS A NETWORK OF PROVIDERS, IMPLEMENTATION OF COORDINATED PREVENTION, CLINICAL AND PEER INTERVENTIONS ACROSS THE NETWORK; AND INCREASE POSITIVE FAMILY MANAGEMENT; ADULT ORIENTED RECOVERY CENTERS AND YOUTH CLUBHOUSES TO PROMOTE SUBSTANCE FREE POSITIVE SOCIAL ACTIVITIES TO PROMOTE RECOVERY. THE EXISTING REGIONAL NETWORKS PROVIDE AN OPPORTUNITY FOR THE STATE TO MEET THE GOALS OF THE SOR GRANT AT A REGIONAL LEVEL, ACROSS THE STATE TO ENSURE UNIVERSAL ACCESS TO OUD IDENTIFICATION, OUTREACH, HARM REDUCTION SERVICES, MEDICATION ACCESS, PREVENTION, AND RECOVERY SUPPORT.

NYS OASAS SOR 4 - THE NEW YORK STATE (NYS) OFFICE OF ADDICTION SERVICES AND SUPPORTS (OASAS) WILL CONTINUE TO FUND THE REGIONAL NETWORK APPROACH TO PREVENTION, HARM REDUCTION, TREATMENT, AND RECOVERY TO SERVE NYS RESIDENTS WHO HAVE AN OPIOID USE DISORDER (OUD) OR STIMULANT USE DISORDER (STUD), ARE AT RISK FOR DEVELOPING AND OUD OR STUD, OR ARE IN RECOVERY FROM AN OUD OR STUD. THE REGIONAL NETWORK APPROACH, INITIATED UNDER THE 2020 STATE OPIOID RESPONSE GRANT, GAVE PROVIDERS THE OPPORTUNITY TO DEVELOP A REGIONAL NETWORK OF CARE FOR OUD AND STUD THROUGH SHARED KNOWLEDGE, THE IDENTIFICATION OF OPPORTUNITIES FOR PARTNERSHIP AND THE SHARING OF, OR CO CREATION OF, PROGRAMS. NETWORKS WILL CONTINUE TO INVEST IN REGIONAL INITIATIVES AIMED AT IMPROVING DATA QUALITY, PROMOTING STAFF TRAINING/WELLNESS AND DEVELOPING SHARED REFERRAL SYSTEMS USING TECHNOLOGY. NETWORK PROVIDERS FORMALIZED COLLABORATIONS WITH MEMORANDUMS OF UNDERSTANDING, BUILT NEW SERVICES, AND JOINTLY PURSUED PROGRAM FUNDING OPPORTUNITIES. WITHIN EACH OF THE 13 REGIONAL NETWORKS, PROVIDERS WILL CONTINUE DELIVERING SERVICES INCLUDING: EXPANDING ACCESS TO MEDICATION FOR OPIOID USE DISORDER (MOUD); LINKING HOSPITAL EMERGENCY DEPARTMENTS AND URGENT MEDICAL CARE CENTERS TO PEER SUPPORTS, OUTPATIENT TREATMENT PROGRAMS, AND ADDICTION MEDICINE SPECIALISTS TO IMPROVE INTERVENTION AND INITIATION OF MOUD; LINKING FEDERALLY QUALIFIED HEALTH CENTERS TO OUTPATIENT TREATMENT PROGRAMS TO INCREASE PATIENT ACCESS TO MOUD AND LEVERAGE RESOURCES AND EXPERTISE ACROSS PATIENT SETTINGS; INTEGRATING AND SUPPORTING THE PEER WORKFORCE WITHIN TREATMENT AND RECOVERY SETTINGS; DELIVERING RECOVERY SERVICES, INCLUDING PEER SERVICES, HOUSING ASSISTANCE, VOCATIONAL SUPPORT, NON-MEDICAL TRANSPORTATION, AND SERVICES FOR THE CHILDREN AND FAMILIES OF THOSE IN RECOVERY; INNOVATIVE TELEHEALTH STRATEGIES IN RURAL AND UNDERSERVED AREAS TO INCREASE THE CAPACITY OF COMMUNITIES TO SUPPORT OUD/STUD TREATMENT AND RECOVERY; OPERATING ACCESS AND SUPPORT HOTLINES TO SUPPORT REGIONAL NETWORKS; PROVIDING SERVICES AND SUPPORTS SPECIFICALLY DESIGNED TO MEET THE NEEDS OF THE YOUTH AND YOUNG ADULT POPULATIONS; PARTNERING WITH EXISTING RECOVERY COMMUNITY AND OUTREACH CENTERS AND YOUTH CLUBHOUSES; PROVIDING SERVICES AND SUPPORTS THAT TARGET CRIMINAL LEGAL SYSTEM POPULATIONS; AND MAINTAINING A JUSTICE-INVOLVED PEER PROGRAM TO ADDRESS SIGNIFICANT CHALLENGES UPON REENTRY INTO THE COMMUNITY FROM THE CRIMINAL LEGAL SYSTEM. ADDITIONALLY, OASAS WILL CONTINUE TO SUPPORT THE DISTRIBUTION OF HARM REDUCTION SUPPLIES THROUGH OPIOID OVERDOSE PREVENTION COMMUNITY TRAININGS, AN OASAS WEB-BASED HARM REDUCTION SUPPLY ORDERING PORTAL, AND HARM REDUCTION VENDING MACHINES ACROSS THE STATE. PROJECT GOALS ARE TO: ENHANCE COORDINATION AND DELIVERY OF COMPREHENSIVE PREVENTION SERVICES THROUGH REGIONAL NETWORKS; INCREASE THE NUMBER OF PERSONS WITH OUD OR STUD RECEIVING TREATMENT THROUGH PEER OUTREACH AND ENGAGEMENT ENCOUNTERS; INCREASE THE CAPACITY OF THE SUD PROVIDERS TO PROVIDE HARM REDUCTION SERVICES TO PEOPLE WHO USE DRUGS; INCREASE THE NUMBER OF PERSONS WITH OUD OR STUD RECEIVING INITIAL OR RE-ENGAGEMENT IN RECOVERY-RELATED SERVICES BY ESTABLISHING AND STRENGTHENING LINKAGES BETWEEN PROGRAMS; AND INCREASE THE NUMBER OF VULNERABLE PERSONS WITH OUD OR STUD RECEIVING RECOVERY-RELATED SERVICES THROUGH EXPANSION AND ENHANCEMENT OF SERVICES AND ACCESS. THIS PROJECT ANTICIPATES SERVING APPROXIMATELY 5,100 PERSONS PER YEAR THROUGH PREVENTION SERVICES, 22,000 PER YEAR THROUGH TREATMENT SERVICES, AND 16,200 PER YEAR THROUGH RECOVERY SERVICES.

NYS OASAS SOR 2020

THE NEW YORK STATE OFFICE OF MENTAL HEALTH

HEAD START AND EARLY HEAD START

NYS OASAS SOR

EXPANDS MARKETS FOR CLIMATE SMART DAIRY PRODUCTS IN CALIFORNIA AND SUPPORTS FARMER IMPLEMENTATION AND MONITORING OF CLIMATE SMART PR ACTICES.

FOR 30 YEARS SAN JOSE STATE UNIVERSITY (SJSU) HAS PARTNERED WITH NASA AMES RESEARCH CENTER (ARC) ON COLLABORATIVE HUMAN SYSTEMS INTEGRATION RESEARCH (HSIR) THAT HAS MADE AIR AND SPACE TRAVEL MORE SAFE EFFICIENT AND RELIABLE. WE NOW PROPOSE A FIVE-YEAR RESEARCH PLAN TO BUILD UPON OUR COLLABORATIVE WORK IN THE HUMAN SYSTEMS INTEGRATION DIVISION (CODE TH) OTHER ARC DIVISIONS AND THE US MILITARY UNDER COOPERATIVE AGREEMENT NNX12AB08A. THE RESEARCH WE PROPOSE FULFILLS THE TECHNICAL AREAS PREVIOUSLY IDENTIFIED IN NASA SOLICITATION NNA11364623A THAT REMAIN RELEVANT TO THE MISSION AND STRATEGIC GOALS OF NASA AND OTHER GOVERNMENTAL ORGANIZATIONS (E.G. FAA US ARMY). THESE AREAS ARE: (1) HUMAN-AUTOMATION INTERACTION (2) HUMAN-COMPUTER INTERACTION AND (3) INDIVIDUAL- AND TEAM-PERFORMANCE FACTORS. THIS PROPOSAL WILL ALSO EXPAND UPON PREVIOUS RESEARCH BY INCORPORATING NEW EMPHASES THAT HAVE EMERGED SINCE OUR LAST PROPOSAL. THIS PROPOSAL ENCOMPASSES THE EXISTING SJSU/ARC LABORATORY ORGANIZATION AND TECHNICAL COMPETENCIES BASED ON OUR KNOWLEDGE OF NASA S PROCESSES ACQUIRED DURING OUR LONG PARTNERSHIP. WE ANTICIPATE SIGNIFICANT BENEFITS FOR NASA FROM MAINTAINING THAT PARTNERSHIP INCLUDING: (1) AN EXISTING STRONG RESEARCH AND MANAGEMENT INFRASTRUCTURE THAT WILL REMAIN ON-SITE THROUGHOUT THE AWARD PERIOD PROVIDING TIMELY AGILE AND ADAPTIVE RESPONSES TO NASAS NEEDS AND PRIORITIES; (2) LONG-TERM CONTINUITY FOR RESEARCH ACTIVITIES; (3) SHARED GOALS AND SHARED INSTITUTIONAL KNOWLEDGE; (4) KNOWN AND RESPECTED PERSONNEL WHO HAVE ESTABLISHED PRODUCTIVE WORKING RELATIONSHIPS WITH NASA SCIENTISTS AND MANAGEMENT; (5) ACADEMIC STUDENT AND PUBLIC OUTREACH PROGRAMS CREATED TO ENHANCE NASA PROJECTS DEVELOP RELEVANT WORKFORCE SKILLS AND MEET NASA S MISSION AND STRATEGIC GOALS; (6) AN EXPERIENCED MANAGEMENT TEAM WITH A STRONG FOCUS ON SUSTAINED COLLABORATION; (7) A SUPPORTIVE AND RESPONSIVE ORGANIZATION IN THE SAN JOSE STATE UNIVERSITY RESEARCH FOUNDATION (SJSURF); (8) PROVEN SUCCESSFUL PROJECT MODELS; AND (9) RESOURCE EFFICIENCIES THROUGH AVOIDANCE OF A TIME-CONSUMING AND COSTLY TRANSITION TO ANOTHER RESEARCH ORGANIZATION.

KENTUCKY CAN HEAL (COMMUNITIES AND NETWORKS HELPING END ADDICTION LONG-TERM)

DRCR NETWORK

ANTICIPATED DRAMATIC INCREASES IN AIR TRAFFIC HAVE FUELED THE PLANNED CONVERSION TO THE NEXT GENERATION AIR TRANSPORTATION SYSTEM, WHICH REINVENTS AI

DIABETIC RETINOPATHY CLINICAL RESEARCH NETWORK

PEDIATRIC EYE DISEASE INVESTIGATOR GROUP NETWORK

EASTERN COOPERATIVE ONCOLOGY GROUP OPERATIONS OFFICE

U.S. ATLAS OPERATIONS: DISCOVERY AND MEASUREMENT AT THE ENERGY FRONTIER

HUMAN SYSTEMS INTEGRATION: COLLABORATIVE HUMAN FACTORS RESEARCH TO IMPROVE THE SAFETY EFFICIENCY AND RELIABILITY OF NASAS AERONAUTICS AND SPACE MISSIONS: PHASE 2

BIOLOGY WITH X-RAY LASERS

U.S. ATLAS OPERATIONS: DISCOVERY AND MEASUREMENT AT THE ENERGY FRONTIER -RESEARCHERS IN HIGH ENERGY PHYSICS SEEK TO UNDERSTAND THE FUNDAMENTAL NATURE OF MATTER AND THE BASIC FORCES THROUGH WHICH IT INTERACTS. ONE WAY THEY DO THIS IS BY OBSERVING WHAT HAPPENS WHEN COUNTER-ROTATING BEAMS OF PROTONS COLLIDE. THE CHARACTERISTICS OF THE DEBRIS PRODUCED IN THE COLLISIONS CAN REVEAL THE BASIC PHYSICS OF FUNDAMENTAL PARTICLES AND THE FORCES BETWEEN THEM. HIGHLY SOPHISTICATED PARTICLE DETECTORS AND ANALYSIS METHODS ARE REQUIRED TO MEASURE THESE CHARACTERISTICS. NSF PROVIDES FUNDING TO U.S. RESEARCHERS TO CONDUCT RESEARCH IN EXPERIMENTAL HIGH ENERGY PHYSICS USING THE ATLAS DETECTOR AT THE LARGE HADRON COLLIDER (LHC), THE WORLD?S PREMIER LABORATORY FOR THIS RESEARCH. IN ADDITION TO DIRECTLY SUPPORTING RESEARCH ACTIVITIES, NSF WILL PROVIDE, VIA THIS AWARD, FUNDING TO TWENTY-TWO U.S. UNIVERSITIES TO MAINTAIN THE OPERATION OF U.S.-SUPPLIED COMPONENTS OF THE ATLAS DETECTOR AND ITS SUPPORTING SOFTWARE AND COMPUTING SYSTEMS, DEVELOP NEW SOFTWARE TOOLS, AND INSTALL AND COMMISSION DETECTOR ENHANCEMENTS IN PREPARATION FOR MORE INTENSE OPERATION PLANNED TO COMMENCE IN 2027. THIS AWARD WILL ALSO PROMOTE SCIENCE EDUCATION AND PROMOTE DIVERSE PARTICIPATION IN RESEARCH. THE LARGE HADRON COLLIDER IS LOCATED AT THE EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH (CERN) NEAR GENEVA SWITZERLAND. U.S. PARTICIPATION IN ATLAS WILL STIMULATE THE DEVELOPMENT OF A SCIENTIFIC AND TECHNICALLY EDUCATED WORKFORCE, ADVANCING THE MULTIDISCIPLINARY APPLICATION OF TECHNOLOGY, AND THE POPULARIZATION AND DISSEMINATION OF SCIENCE TO THE GENERAL PUBLIC. THE AWARD WILL SUPPORT ACTIVITIES THAT PROVIDE OPPORTUNITIES TO DEVELOP AND MAINTAIN COMPLEX DETECTOR APPARATUS, CUSTOM ANALOG AND DIGITAL ELECTRONICS AND SOFTWARE SYSTEMS FOR DATA MANAGEMENT, AND TO SUPPORT DATA PROCESSING AND TECHNICAL ANALYSES OF DETECTOR SYSTEMS. TECHNICAL PROFESSIONALS ARE REQUIRED TO PERFORM MANY OF THESE TASKS, INCREASING THE EXPERTISE OF THE U.S. WORK FORCE. THE OPERATION OF EXISTING DETECTOR COMPONENTS, DESIGN OF UPGRADE COMPONENTS, AND RELATED RESEARCH ACTIVITIES CREATE OPPORTUNITIES FOR INTERDISCIPLINARY COLLABORATION AMONG UNIVERSITY PHYSICS PERSONNEL, UNIVERSITY PERSONNEL IN ENGINEERING DEPARTMENTS, AND PHYSICS DEPARTMENT TECHNICAL PERSONNEL AS PHYSICISTS, ELECTRICAL ENGINEERS, MECHANICAL ENGINEERS AND COMPUTER SCIENTISTS WORK WITH POST-DOCS AND STUDENTS. SIMILARLY, PHYSICS PERSONNEL WILL WORK CLOSELY WITH COMPUTING PROFESSIONALS AT THEIR HOME INSTITUTIONS AND AT NATIONAL LABORATORIES TO SUPPORT THE VARIOUS SOFTWARE AND COMPUTING ACTIVITIES. TECHNICAL PART: THIS AWARD SUPPORTS THE DEVELOPMENT AND OPERATION OF THE INSTRUMENTATION AND ANALYSIS TOOLS THAT ARE ESSENTIAL TO STUDYING DEBRIS FROM PROTON-PROTON COLLISIONS. THESE TOOLS ARE ESSENTIAL FOR ANSWERING BASIC, FOUNDATIONAL QUESTIONS, SUCH AS ?WHAT IS THE ORIGIN OF MASS OF THE ELEMENTARY PARTICLES?? THE HIGGS BOSON DISCOVERY, A PHYSICAL MANIFESTATION OF THE MECHANISM THAT GENERATES ELEMENTARY PARTICLE MASSES, LED TO THE 2013 PHYSICS NOBEL PRIZE THAT WAS AWARDED TO PETER HIGGS AND FRANCOIS ENGLERT. IS THAT THE END OF THE STORY, OR ARE THERE OTHER, AS-OF-YET UNDISCOVERED, CONTRIBUTIONS TO THIS PROCESS? OTHER FUNDAMENTAL QUESTIONS, EQUALLY IMPORTANT, MAY HAVE ANSWERS THAT DEPEND, AT LEAST IN PART, ON THE PHYSICS OBSERVED THROUGH THE CONTINUED OPERATION AND ANALYSIS OF DATA OBTAINED FROM THE LHC. ?WHAT IS THE DARK MATTER THAT ACCOUNTS FOR 25% OF THE MASS OF THE UNIVERSE? CAN DARK MATTER BE PRODUCED AND OBSERVED AT THE LHC? CAN EVIDENCE OF EXTRA DIMENSIONS PREDICTED IN SOME MODELS BE FOUND AT LHC ENERGIES? ARE THERE PARTICLES WITH EXOTIC PROPERTIES, UNLIKE ANY FORMS OF MATTER OBSERVED SO FAR, WHOSE EXISTENCE IS PREDICTED BY SOME THEORIES THAT EXTEND THE STANDARD MODEL OF ELEMENTARY PARTICLES?? IN EACH CASE, ANSWERING THE QUESTION REQUIRES THE AGGREGATION OF LARGE AMOUNTS OF DATA FROM WHICH TO DRAW MEANINGFUL STATISTICAL INFERENCES. THIS AWARD WILL ENABLE RESEARCHERS TO DOUBLE THE AMOUNT OF DATA COLLECTED FOR ANALYSIS AND INVESTIGATIONS OF THESE PHENOMENA. IT WILL ENABLE PREPARATIONS THAT WILL LEAD TO FUTURE COLLECTION OF ABOUT TEN TIMES THE CURRENTLY AVAILABLE DATA. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

MOLECULAR AND IMMUNOLOGIC ANALYSIS OF THE PATHOBIOLOGY OF ANTHRAX

DATA COLLECTION

TO IMPROVE MUNICIPAL GOVERNANCE, EXPANDING THE ROLE FOR CIVIL SOCIETY ADVOCACY, AND INCREASING THE RESPONSIVENESS OF THE PARLAIMENT.

PEDIATRIC EYE DISEASE INVESTIGATOR GROUP

HEALTH CENTER CLUSTER

CRISIS COUNSELING

CALIFORNIA EMERGING INFECTIONS PROGRAM

HEALTH CENTER CLUSTER

ECOG-ACRIN BIOREPOSITORIES TO SUPPORT NCTN

AMERICAN RESCUE PLAN ACT FUNDING FOR HEALTH CENTERS

CALIFORNIA ELC 2014

HIV CENTER FOR CLINICAL AND BEHAVIOR STUDIES

KENTUCKY CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE

THE LII ACTIVITY WILL PROVIDE AND LEVERAGE INVESTMENT CAPITAL AND BUILD SUPPORTING INSTITUTIONS IN LEBANON. LII WILL SUPPORT LOCAL ENTREPRENEURS AND SMALL AND MEDIUM ENTERPRISES (SMES).

PROMOTING THE READINESS OF MINORS IN SUPPLEMENTAL SECURITY INCOME (PROMISE)

DATA COLLECTION

NUTRITION AND SUPERFUND CHEMICAL TOXICITY

DATA COLLECTION

UNIVERSITY OF KENTUCKY MARKEY CANCER CENTER - CANCER CENTER SUPPORT GRANT

BROOKLYN WOMEN'S INTERAGENCY HIV STUDY (WIHS) IV

SUNY COLLEGE AT BUFFALO INSTITUTIONAL HEERF

BUFFALO CLINICAL AND TRANSLATIONAL RESEARCH CENTER

HEALTH CENTER CLUSTER

SVTC SOLAR: A PHOTOVOLTAIC MANUFACTURING DEVELOPMENT FACILITY

TO IMPROVE THE OPPORTUNITIES AND LIVELIHOODS OF MARGINALIZED AND DISADVANTAGED YOUTH IN SUPPORT OF THE YOUTH DEVELOPMENT PROGRAM.

CLINICAL SERVICES FOR WORLD TRADE CENTER RESPONDERS

THE NORTHEAST REGIONAL FOOD BUSINESS CENTER (RFBC) WILL SEEK TO SYNERGIZE EFFORTS AND BUILD TRUSTACROSS THE REGION BETWEEN STATE DEPARTMENTS OF AGRICULTURE, UNIVERSITIES, COOPERATIVE EXTENSIONSERVICES, TECHNICAL ASSISTANCE PROVIDERS, AND FOOD SYSTEM STAKE

DATA COLLECTION

NSF ENGINES: UPSTATE NEW YORK ENERGY STORAGE ENGINE -THIS NSF ENGINES AWARD TO THE UPSTATE NEW YORK ENERGY STORAGE ENGINE WILL ADDRESS THE ENTIRE BATTERY TECHNOLOGY VALUE CHAIN TO ESTABLISH A TECH-BASED, INDUSTRY-DRIVEN INNOVATION HUB. BATTERY TECHNOLOGY DEVELOPMENT AND DEPLOYMENT INVOLVES MULTICOMPONENT DISTRIBUTED SUPPLY CHAINS. THE NSF ENGINE WILL COVER THE BATTERY LIFECYCLE SPANNING MATERIALS, COMPONENTS, CELLS, MODULES, PACKS, SYSTEM MANAGEMENT, INDUSTRIAL APPLICATIONS, AND RECYCLING, WITH INDUSTRY PARTNERS SECURED ALONG EACH STEP. THE NSF ENGINE WILL ADDRESS INDUSTRY- AND TECHNOLOGY-LEVEL CHALLENGES INCLUDING MATERIAL SOURCING AND RECOVERY, BATTERY COMPONENT INNOVATION, SAFETY TESTING AND CERTIFICATION, PILOT MANUFACTURING, APPLICATIONS INTEGRATION, AND WORKFORCE TRAINING. THE INDUSTRY- AND COMMUNITY-RESPONSIVE NSF ENGINE PROGRAMS WILL CATALYZE HIGH-TECH R&D OUTCOMES, BROADEN PARTICIPATION TO BUILD AN INCLUSIVE INNOVATION ECOSYSTEM, AND DRIVE EQUITABLE ECONOMIC DEVELOPMENT AT THE REGIONAL AND NATIONAL LEVELS. THE ENGINE WILL LEVERAGE TRANSFORMATIONAL INVESTMENTS FROM THE ECONOMIC DEVELOPMENT ADMINISTRATION AND THE NSF AND THE COLLECTIVE CAPACITY OF NSF ENGINE PARTNERS TO POSITION UPSTATE NEW YORK?S EMERGING BATTERY ECOSYSTEM AS AN INTERNATIONAL LEADER IN THE SECTOR, POWERING AMERICAN BATTERY INNOVATION AND SUPPLY CHAIN RESILIENCY. THE UPSTATE NEW YORK ENERGY STORAGE ENGINE SERVICE REGION COMPRISES 27 COUNTIES IN WESTERN, CENTRAL, SOUTHERN TIER, AND FINGER LAKES REGIONS OF THE STATE OF NEW YORK SPANNING MICROPOLITAN AND MAJORITY-RURAL AREAS WITH MORE THAN 4 MILLION RESIDENTS AND MORE THAN 100 FEDERALLY DESIGNATED OPPORTUNITY ZONES. THE REGION HAS SUFFERED FROM DECADES OF ECONOMIC DOWNTURN AND HAS 30% RURAL AND 28% ENVIRONMENTAL JUSTICE COMMUNITIES. THE NSF ENGINE LEVERAGES A LARGE ECOSYSTEM OF CORE PARTNERS THAT INCLUDES R1 UNIVERSITIES (BINGHAMTON UNIVERSITY, CORNELL UNIVERSITY, ROCHESTER INSTITUTE OF TECHNOLOGY, SYRACUSE UNIVERSITY, AND UNIVERSITY OF BUFFALO), MAJOR INDUSTRY PARTNERS (INCLUDING BAE, RAYMOND, LI-CYCLE, IM3NY, NYSEG, ELECTROVAYA, KODAK AND OTHERS), MANY OF THE REGION?S SMALL AND MEDIUM MANUFACTURERS, INDUSTRY TRADE ORGANIZATIONS (INCLUDING NEW YORK BATTERY AND ENERGY STORAGE TECHNOLOGY CONSORTIUM ? NY-BEST), INCUBATORS AND INVESTORS (INCLUDING LAUNCH NY AND INCUBATORWORKS), AND WORKFORCE DEVELOPMENT PARTNERS (INCLUDING BOCES, SUNY CORNING COMMUNITY COLLEGE, SUNY BROOME COMMUNITY COLLEGE, JAMESTOWN COMMUNITY COLLEGE, GREEN FORCE). THIS DIVERSE COALITION OF PARTNERS WILL BE CENTRAL TO R&D, TRANSLATION, AND WORKFORCE DEVELOPMENT EFFORTS. THE KEY AREAS IDENTIFIED FOR USE-INSPIRED R&D WERE SHAPED BY EXTENSIVE DISCUSSIONS WITH INDUSTRY PARTNERS, NATIONAL LABORATORIES, AND FEDERAL AGENCIES. THESE AREAS INCLUDE INNOVATIONS IN MATERIAL SOURCING AND PROCESSING, ALTERNATIVE CHEMISTRIES AND NEXT-GENERATION BATTERY TECHNOLOGIES, IMPROVED METROLOGY, BATTERY MANUFACTURING PROCESS INNOVATION, MATERIAL RECOVERY AND RECYCLING, AND SAFETY AND TESTING. ALL THESE RESEARCH THRUSTS ARE AIMED AT DEVELOPING LEAPFROG INNOVATIONS TO BOLSTER DOMESTIC BATTERY PRODUCTION AND REDUCE DEPENDENCE ON NON-DOMESTIC SUPPLY CHAINS. LITHIUM BATTERY PRODUCTION DEPENDS UPON CRITICAL MINERALS WHOSE DOMESTIC SUPPLY IS AT RISK FOR DISRUPTION, AND THERE ARE FURTHER MAJOR GAPS IN THE PROCESSING OF ACTIVE MATERIALS AND PRODUCTION OF KEY BATTERY COMPONENTS; THESE GAPS UNDERSCORE THE NEED TO DEVELOP ALTERNATIVE APPROACHES, SUCH AS INTRODUCTION OF NEW AND ALTERNATIVE MATERIALS, AS WELL AS IMPROVED METROLOGY IN PRODUCTION LINES TO REDUCE WASTE IN MANUFACTURING. MATERIAL RECOVERY AND RECYCLING, AS WELL AS THE DEVELOPMENT OF ALTERNATIVE CHEMISTRIES, CAN REDUCE THE NEED FOR CRITICAL MINERALS AND DEPENDENCE ON UNSTABLE FOREIGN SUPPLY CHAINS. FINALLY, WITH SAFETY AND TESTING ISSUES CRITICAL AT VARIOUS LEVELS OF BATTERY DEVELOPMENT AND PRODUCTION, THE NSF ENGINE WILL PURSUE A HOLISTIC DESIGN APPROACH TO IMPROVING BATTERY SYSTEM SAFETY, WITH SYSTEM-SCALE TESTING CAPABILITIES. THE UPSTATE NEW YORK ENERGY STORAGE ENGINE PROVIDES A COMPREHENSIVE TECHNOLOGY TRANSLATION PLAN FROM LAB TO MARKET THAT STARTS WITH INDUSTRY-INFORMED R&D AND TRANSITIONS TECHNOLOGY DEVELOPMENT THROUGH VENTURE LAUNCH AND GROWTH, PROOF-OF-CONCEPT, PROTOTYPING, TO PILOT PROJECTS, SCALING, AND COMMERCIAL DEVELOPMENT WITH EXTERNAL FUNDING. SPECIFICALLY, THE NSF ENGINE WILL PROVIDE SUPPORT FOR EARLY-STAGE REGIONAL STARTUPS WITH GAP GRANTS FOR EARLY DEVELOPMENT PROTOTYPING EFFORTS, AS WELL AS FOR VENTURE DEVELOPMENT NEEDS INCLUDING INTELLECTUAL PROPERTY. THE NSF ENGINE WILL PROVIDE A COMPREHENSIVE SUITE OF REGIONAL R&D, TESTING, AND PILOT PRODUCTION INFRASTRUCTURE TO SUPPORT BATTERY DEVELOPMENT AT VARIOUS STAGES. THE UPSTATE NEW YORK ENERGY STORAGE ENGINE HAS WORKED CLOSELY WITH INDUSTRY PARTNERS TO IDENTIFY SKILLS AND TRAINING NEEDS, AND WITH WORKFORCE DEVELOPMENT ORGANIZATIONS TO DEVELOP A COMPREHENSIVE PLAN FOR WORKFORCE DEVELOPMENT TO SUPPORT THIS IMPORTANT INDUSTRY. THE NSF ENGINE WILL EXPAND STEM EDUCATION AND WORKFORCE DEVELOPMENT ACROSS ALL LEVELS TO DELIVER SKILLED TECHNICIANS, ENGINEERS, AND ENTREPRENEURS TO SUPPORT THE PROJECTED GROWTH OF THE INDUSTRY AND THE DEVELOPMENT AND DEPLOYMENT OF BATTERY INNOVATIONS. WORKFORCE DEVELOPMENT EFFORTS SPAN FROM NEXT-GENERATION PRE-COLLEGE; TO UNDERGRAD, GRAD, AND POSTDOC; TO RESKILLING OF EXISTING WORKFORCE. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

SAVANNAH RIVER ECOLOGY LABORATORY.

THIS EDA INVESTMENT SUPPORTS THE NEW ENERGY NEW YORK COALITION, LED BY THE STATE UNIVERSITY OF NEW YORK (SUNY) AT BINGHAMTON, WITH ACCELERATING BATTERY TECHNOLOGY INNOVATION IN NEW YORK BY TRANSFORMING NEW YORK'S SOUTHERN TIER INTO A GLOBAL HUB OF ENERGY STORAGE MANUFACTURING. THE PROJECTS FUNDED AS PART OF THIS AWARD INCLUDE BUILDING A LITHIUM-BASED BATTERY DEVELOPMENT MANUFACTURING FACILITY, THE BATTERY-NY CENTER, WHICH WILL PROVIDE TESTING, CERTIFICATION, AND SCALE-UP CAPACITY FOR NEW PRODUCTS AND COMPANIES. COMPLEMENTARY PROJECT LEADS WILL WORK WITH EXISTING MANUFACTURERS TO ESTABLISH THEM AS ELIGIBLE SUPPLIERS FOR ENERGY PRODUCTS; AND EXPAND WORKFORCE TRAINING PROGRAMS TO ADDRESS NEEDS OF THE GROWING CLUSTER. ONCE IMPLEMENTED, THE INVESTMENT WILL HELP DEVELOP AND STRENGTHEN REGIONAL INDUSTRY CLUSTERS - ALL WHILE EMBRACING ECONOMIC EQUITY, CREATING GOOD-PAYING JOBS, AND ENHANCING U.S. COMPETITIVENESS GLOBALLY.

NEW COOPERATIVE AGREEMENT FOR USAID COMMUNITY HIV AND AIDS CARE AND TREATMENT ACTIVITY; INITIAL OBLIGATE $4,000,000 .

SAN FRANCISCO VACCINE AND PREVENTION UNIT

CLINICAL TRIALS NETWORK: LONG ISLAND REGIONAL NODE

CHILD WELFARE TRAINING: THE NATIONAL CHILD WELFARE WORKFORCE INSTITUTE

KENTUCKY OVERDOSE DATA TO ACTION

DATA COLLECTION

DEVELOPMENTAL EXPOSURE ALCOHOL RESEARCH CENTER

ACCELERATING MEDICINES PARTNERSHIP-AUTOIMMUNE AND IMMUNOLOGIC DISEASE TISSUE RESEARCH CORE - PROJECT SUMMARY THE SUCCESSFUL ACCELERATING MEDICINES PARTNERSHIP IN RA/LUPUS (AMP1) PROGRAM FOCUSED ON DECONSTRUCTING DISEASE TISSUES THROUGH SINGLE-CELL TRANSCRIPTOMIC TECHNOLOGIES. AMP IN AUTOIMMUNE AND IMMUNE-MEDIATED DISEASES (AMP AIM) IS POISED TO EXPAND THE UNDERSTANDING OF THE CELLULAR COMPONENTS AND INTERACTIONS AT PLAY IN FOUR AUTOIMMUNE DISEASE TARGET TISSUES WITH NEW SPATIALLY-ORIENTED MODALITIES OF SINGLE-CELL ANALYSES. AS IN THE AMP1, THE AMP AIM WILL REQUIRE HIGH-QUALITY SAMPLES FOR INTERROGATION, STANDARDIZED METHODS TO ASSESS SAMPLE QUALITY AND COMMON MOLECULAR/PHENOTYPIC BIOMARKER TESTING ACROSS ALL SUBJECTS FOR A CLINICALLY AND MOLECULARLY WELL-PHENOTYPED COHORT TO APPLY NEW CUTTING-EDGE TECHNOLOGIES TO RE-CONSTRUCT DISEASE. THE OMRF TISSUE RESEARCH CORE (TRC) IS UNIQUELY POSITIONED TO SUCCESSFULLY DEPLOY A CENTRALIZED TRC ACROSS ALL DISEASE TEAMS FOR LUPUS (SLE), RA, SJOGREN’S DISEASE (SJD), AND PSORIATIC SPECTRUM DISEASES (PSD). WITH A ROBUST, EXISTING INFRASTRUCTURE, CAPABILITIES, AND LEADERSHIP, THE OMRF TRC WILL PROVIDE THE NETWORK WITH: 1) STANDARDIZED PROTOCOLS AND MANUALS TO BE USED ACROSS ALL PARTS OF THE NETWORK, 2) CENTRALIZED LOGISTICS FOR COLLECTION, TRANSPORT, STORAGE AND DISSEMINATION, 3) CENTRALIZED, TRANS-DISEASE QC AND INITIAL TESTING OF ALL SAMPLES IN A CONTINUOUS MANNER AS SAMPLES ARE COLLECTED FOR EARLY QUALITY MANAGEMENT AND IDENTIFICATION OF SAMPLES OF HIGH IMPORTANCE, 4) TISSUE IMAGING (BASIC HISTOLOGY & INITIAL HIGH-DIMENSIONAL) UTILIZING SAMPLE SPARING WORKFLOWS THAT PROVIDE SCORING AND QC OF TISSUE, PLUS INITIAL MULTI-OMIC, SPATIALLY-INFORMED DATA SETS, AND 5) INDUSTRY STANDARD REPOSITORY AND IMAGE DATABASE SYSTEMS. THE OMRF TRC IS CENTRALLY LOCATED, MAKING IT AN IDEAL LOCATION FOR LOGISTICS MANAGEMENT AND, SINCE IT WAS THE REPOSITORY FOR AMP1 CARRIES NETWORK KNOWLEDGE ALONG WITH THE EXTENSIVE EXPERIENCE AS REPOSITORY FOR MULTIPLE OTHER NATIONAL CONSORTIUMS, PROVIDES FOR CONTINUITY DURING TRANSITION TO AMP AIM. THE OMRF TRC ALREADY HAS INFRASTRUCTURE IN PLACE AND THE REPUTATION THAT FOLLOWS FROM STRONG LEADERSHIP TO CONTINUE TO ACT AS AN IDEAL HONEST BROKER FOR THE NETWORK. THE OMRF TRC HAS STATE-OF-THE-ART FACILITIES THAT ARE INTEGRATED WITH ADVANCED TECHNOLOGIES WITHIN ITS ASSOCIATED CORES TO RECEIVE, STORE, COLLECT MEANINGFUL QC AND INITIAL DATA SETS, AND DISSEMINATE SELECTED SAMPLES TO TECHNOLOGY AND ANALYTIC CORES (TAC) POISED TO PROVIDE DATA FROM EMERGING TECHNOLOGIES TO BUILD UPON THE DEEP CLINICAL AND INITIAL CHARACTERIZATION DATA, TO MAKE EXTREMELY HIGH- DIMENSIONAL, ROBUST DATASETS. CONSIDERING THE LONGSTANDING HISTORY OF THE OMRF TRC IN BIOBANKING SAMPLES FOR AUTOIMMUNE DISEASE STUDIES, THE OMRF TRC IS POISED TO A PRODUCE A SOLID FOUNDATION OF BANKED SAMPLES, ORGANIZED LOGISTICS, AND INITIAL MULTI-OMIC DATASETS THAT WILL SETUP THE NETWORK FOR SUCCESS IN RECONSTRUCTING OUR MECHANISTIC UNDERSTANDING AND CLINICAL APPLICATION OF THESE NEW DATA TO BETTER TREAT THESE AUTOIMMUNE DISEASES.

EXPANDING EXCELLENCE IN DEVELOPMENTAL BIOLOGY IN OKLAHOMA

CALIFORNIA EMERGING INFECTIONS PROGRAM - IN THIS PROPOSAL, THE CALIFORNIA DEPARTMENT OF PUBLIC HEALTH (CDPH), THE UNIVERSITY OF CALIFORNIA, BERKELEY SCHOOL OF PUBLIC HEALTH (UCB-SPH), SELECTED LOCAL AND COUNTY HEALTH DEPARTMENTS, AND OTHER PARTNERS REQUEST AN ADDITIONAL FIVE YEARS OF SUPPORT FOR THE CALIFORNIA EMERGING INFECTIONS PROGRAM (EIP), WHICH WAS ESTABLISHED IN 1994 WITH SUPPORT FROM THE CENTERS FOR DISEASE CONTROL AND PREVENTION AND HAS BEEN RE-FUNDED FOUR TIMES SINCE THEN. WE PROPOSE TO MAINTAIN CORE DISEASE SURVEILLANCE AND RESPONSE CAPABILITIES AND TO IMPLEMENT OR CONTINUE DATA MODERNIZATION EFFORTS WITH THE ACTIVE BACTERIAL CORE SURVEILLANCE AND RELATED ACTIVITIES (ABCS); ACTIVE POPULATION-BASED LABORATORY SURVEILLANCE FOR FOODBORNE DISEASES AND RELATED ACTIVITIES (FOODNET); INFLUENZA AND RSV INFECTIONS RESULTING IN HOSPITALIZATION; POPULATION-BASED SURVEILLANCE FOR HOSPITALIZATIONS RESULTING FROM LABORATORY-CONFIRMED SARS-COV-2, (RESP-NET); SURVEILLANCE FOR AND RELATED STUDIES OF HEALTHCARE-ASSOCIATED INFECTIONS (HAI) AND ANTIMICROBIAL RESISTANCE; SURVEILLANCE FOR HPV INFECTION AND RELATED STUDIES OF THE IMPACT OF HPV VACCINE (HPV-IMPACT); SURVEILLANCE FOR PRION DISEASE, MYALGIC ENCEPHALOMYELITIS/ CHRONIC FATIGUE SYNDROME (ME/CFS) AND ME/CFS-LIKE POST-COVID CONDITIONS, AND THE MPOX VACCINE EFFECTIVENESS EVALUATION AS WELL AS MAINTAIN SURGE CAPACITY THAT CAN ASSIST IN FLEXIBLE RESPONSES TO NEWLY EMERGING INFECTIOUS DISEASE THREATS AND PARTICIPATE IN RAPID POPULATION SURVEYS. IN ADDITION, WE PROPOSE TO CONTINUE TO PROVIDE APPROPRIATE ISOLATES AND/OR SPECIMENS TO CDC; COLLABORATE WITH CDC AND OTHER EIP SITES IN THE MANAGEMENT, ANALYSIS, INTERPRETATION, AND PUBLICATION OF DATA FROM EIP PROJECTS; PROVIDE TRAINING TO WORKING PUBLIC HEALTH PROFESSIONALS, STUDENTS, AND FELLOWS; PARTICIPATE IN AN EXCHANGE PROGRAM; ACT AS A RESOURCE FOR STATES AND OTHER PARTS OF CALIFORNIA WITHOUT EIPS; AND ENSURE REVIEW OF VARIOUS EIP PROJECTS BY APPROPRIATE INSTITUTIONAL REVIEW BOARDS WHENEVER NE CESSARY (FOR CURRENT IRB APPROVALS SEE APPENDIX X). THE CALIFORNIA EIP WILL CONTINUE TO BE ADMINISTERED BY PUBLIC HEALTH FOUNDATION ENTERPRISES, INC., BASED IN THE CITY OF INDUSTRY, CALIFORNIA.

CCNY/MSK CANCER CENTER PARTNERSHIP, TRAINING AND COMMUNITY OUTREACH

SUNY COLLEGE AT BUFFALO EMERGENCY RELIEF FUND FROM CARES ACT

CELL AND MOLECULAR PATHOBIOLOGY OF ALZHEIMER'S DISEASE

THE NEW YORK STATE OFFICE OF ALCOHOLISM AND SUBSTANCE ABUSE SERVICES (OASAS) IN PARTNERSHIP WITH THE RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC. (RFMH) WILL UNDERTAKE A MULTI-PRONGED APPROACH TO ADDRESS THE ISSUES OF OPIOID USE DISORDERS IN THE UNSERVED AND UNDERSERVED AREAS OF THE STATE. OASAS HAS IDENTIFIED HIGH NEED AREAS IN THE STATE AND THROUGH ITS EXISTING INFRASTRUCTURE WILL ENHANCE TREATMENT AND RECOVERY SERVICES. OASAS'S PROPOSAL IS TO DEVELOP CENTERS OF TREATMENT INNOVATION IN HIGH NEED AREAS WHICH WILL INCLUDE DEVELOPING TELE-HEALTH CAPACITY; INCREASING THE NUMBER OF PRESCRIBING PRACTITIONERS FOR MEDICATION ASSISTED TREATMENT VIA TRAINING AND MENTORING; HAVING CARE MANAGERS TO BRIDGE THE GAP BETWEEN BEHAVIORAL HEALTH AND PRIMARY CARE; USE OF LOCALLY PLACED PEER RECOVERY SUPPORT STAFF TO IMPROVE TREATMENT ENGAGEMENT AND RETENTION; ENHANCED CLINICAL STAFF; AND PROVIDING REENTRY SUPPORT FOR INDIVIDUALS BEING RELEASED FROM JAILS/CORRECTIONAL FACILITIES. OASAS WILL ALSO UTILIZE A MULTI-LEVEL PREVENTION APPROACHES INCLUDING DELIVERY OF EVIDENCE-BASED PREVENTION SERVICES TO UNDERSERVED, HARD-TO-REACH YOUTH AND OTHER AT RISKS POPULATIONS, FOSTER CARE SETTINGS AND PERMANENT SUPPORTIVE HOUSING; PROVIDE TRAINING AND DISTRIBUTION OF NALOXONE KITS; AND A TARGETED MEDIA CAMPAIGN. TO SUPPORT A GROWING RECOVERY COMMUNITY OASAS WILL DEVELOP A YOUTH AND YOUNG ADULT STATEWIDE RECOVERY NETWORK AND LOCAL COMMUNITY NETWORKS. OASAS LOOKS TO ESTABLISH A SOCIAL MEDIA CAMPAIGN THAT PROMOTES HEALTH, RECOVERY AND WELLNESS, ESTABLISH PEER SUPPORTS AND TO PROVIDE TECHNICAL ASSISTANCE AND SUPPORT TO LOCAL COMMUNITIES AND NETWORKS OF YOUNG PEOPLE ACROSS NEW YORK STATE.

NYS OPIOID STR PROJECT

BEING A FIVE YEAR COOPERATIVE AGREEMENT WITH A TECOF $24,000,000 AND INITIAL OBLIGATION OF $500,000

CENTER FOR MESOSCALE TRANSPORT PROPERTIES

SAVANNAH RIVER ECOLOGY LABORATORY

F0RMER WORKER SURVEILLANCE PROGRAM

NEXT GENERATION MATERIALS AND PROCESSING TECHNOLOGIES (NEXTGENMATPROTECH)

INVESTING IN INNOVATION - SCALE UP

DATA COLLECTION

CLOSEOUT OF JOIDES RESOLUTION IODP EXPEDITION OBLIGATIONS AND OPERATION OF AN INSTRUMENTED GULF COAST REPOSITORY -THIS AWARD WILL ENABLE TEXAS A&M UNIVERSITY (TAMU) TO CLOSE OUT ALL POST-EXPEDITION INTERNATIONAL OCEAN DISCOVERY PROGRAM (IODP) OBLIGATIONS THAT WILL NOT BE COMPLETED BY THE END OF THE CURRENT AWARD TO THE JOIDES RESOLUTION SCIENCE OPERATOR (JRSO). OBLIGATIONS INCLUDE POST-EXPEDITION EDITORIAL AND SCIENCE MEETINGS, PROGRAMMATIC XRF SCANNING, SAMPLING PARTIES, DATA MIGRATION, LEGACY DOCUMENTATION, PROPERTY DISPOSITION, AND PUBLICATIONS. PUBLICATION OBLIGATIONS ALSO INCLUDE FOUR EXPEDITIONS FOR THE TWO OTHER IODP OPERATORS, WHOSE REPORTS THE JRSO HAS PUBLISHED DURING IODP. IN ADDITION, TAMU WILL CONTINUE OPERATION OF THE GULF COAST REPOSITORY (GCR) CORE COLLECTION (>150 KM OF CORE) WITH SIGNIFICANTLY ENHANCED ANALYTICAL CAPABILITIES, WHICH WILL BE ACHIEVED BY RELOCATING INSTRUMENTATION FROM THE JOIDES RESOLUTION (JR) TO LABORATORIES CURRENTLY BEING RENOVATED IN THE GCR. THE INTELLECTUAL MERIT IS THAT THIS PROJECT WILL PROVIDE CRITICAL ACCESS TO CORES, DATA, AND RELATED SERVICES TO U.S. AND INTERNATIONAL SCIENTIFIC COMMUNITIES TO PURSUE THE OBJECTIVES OUTLINED IN THE FRAMEWORK DURING A TRANSITIONAL PERIOD WHEN THERE WILL NOT BE A DEDICATED U.S. RISERLESS VESSEL. THE PRINCIPAL BROADER IMPACT IS THE RELOCATION OF LABORATORY INSTRUMENTATION FROM THE JR THAT WILL ALLOW THE GCR TO SERVE AS A TRAINING AND OUTREACH FACILITY FOR THE U.S. SCIENTIFIC DRILLING COMMUNITY. IN PARTICULAR, THE GCR WILL PROVIDE AN ENVIRONMENT FOR TRAINING, EDUCATION, AND OUTREACH ACTIVITIES SIMILAR TO THE JR?S SHIPBOARD LABORATORIES. THE INSTRUMENTED GCR WILL HAVE THE BENEFIT OF BROADENING ACCESS TO COHORTS THAT WERE RARELY PART OF THE SHIPBOARD PARTY, INCLUDING NON-R1 INSTITUTIONS AND 2-YR COLLEGES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

CARES INSTITUTIONAL SHARE FUNDING.

PHFE CDPH ELC 2024-2029 - ELC NWSS MPOX APPLICATION

CATEGORY B: PUBLIC HEALTH PROFESSIONALS IN STLT HDS WORKING TO IMPROVE QUALITY, PERFORMANCE, AND OUTCOMES OF INDIVIDUALS, PROGRAMS, AND ORGANIZATIONS

ANTECEDENTS OF SUICIDAL BEHAVIOR RELATED NEUROBIOLOGY

CHILD WELFARE TRAINING: NATIONAL CHILD WELFARE WORKFORCE INSTITUTE

ENHANCED COGNITIVE REHABILITATION TO TREAT COMORBID TBI AND PTSD

UNIVERSITY OF KENTUCKY CENTER FOR CANCER AND METABOLISM

PEANUT RESEARCH INNOVATION LAB (PRIL)

HEALTH CENTER CLUSTER

NEUROBIOLOGY AND DYNAMICS OF ACTIVE SENSING

CATEGORY I: AMA27: SUSTAINABLE CYBER-INFRASTRUCTURE FOR EXPANDING PARTICIPATION -THE STATE UNIVERSITY OF NEW YORK (STONY BROOK UNIVERSITY, IN COLLABORATION WITH THE UNIVERSITY AT BUFFALO) WILL PROCURE AND OPERATE FOR AT LEAST FIVE YEARS A HIGH-PERFORMANCE, HIGHLY ENERGY-EFFICIENT, LARGE-MEMORY COMPUTER SYSTEM RESPONSIVE TO THE INTERESTS AND PRIORITIES OF MULTIPLE SCIENCE AND ENGINEERING (S&E) AND ARTIFICIAL INTELLIGENCE (AI)-FOCUSED RESEARCH COMMUNITIES AND RESEARCH APPLICATIONS IN NATIONAL CYBERINFRASTRUCTURE. THE PROJECT DEPLOYS A SYSTEM UTILIZING THE LOW-COST AND LOW-ENERGY AMPEREONE ARM PROCESSORS THAT EXCEL AT AI INFERENCE, AS WELL AS IMPERFECTLY-VECTORIZED OR PURE SCALAR WORKLOADS THAT CHARACTERIZE MUCH ACADEMIC RESEARCH COMPUTING BUT ARE INEFFICIENTLY (COST, ENERGY, AND PERFORMANCE) SUPPORTED BY CURRENT NSF CYBERINFRASTRUCTURE. THE LARGE MEMORY AND EXCELLENT AI INFERENCE AND GENERATIVE PERFORMANCE OF THIS PROCESSOR AND QUALCOMM AI-200 ACCELERATORS WILL DIRECTLY ADVANCE THE MISSION OF THE NATIONAL ARTIFICIAL INTELLIGENCE RESEARCH RESOURCE TO BROADEN ACCESS TO AI BY BEING EASILY AND TIGHTLY COUPLED INTO DIVERSE APPLICATIONS, YET SCALABLE TO TENS OF THOUSANDS OF SIMULTANEOUS JOBS OR USERS NATIONWIDE. THE PROJECT EMPLOYS A COMPREHENSIVE, MULTILAYERED STRATEGY, WITH REGIONAL AND NATIONAL ELEMENTS TO ENSURE THE WIDEST POSSIBLE BENEFIT OF AMA27. THE TEAM COLLABORATES WITH MULTIPLE INITIATIVES AND NSF PROJECTS, REACHING AN AUDIENCE THAT SPANS HIGH-SCHOOL STUDENTS TO FACULTY. NATIONALLY AND REGIONALLY, AMA27 WILL SUPPORT A VARIETY OF PROJECTS AND WILL PROVIDE TAILORED COURSES AND TRAINING (BOTH IN-PERSON AND REMOTE), HOST STUDENTS AND FACULTY, AND ENCOURAGE EARLY REGISTRATION ACCESS AND FLEXIBLE AND NOVEL ACCESS MODELS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

CARDIAC GENE TRANSFER OF AC & MECHANISMS FOR EFFECTS

** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** COORDINATE THE USDA SARE (SUSTAINABLE AGRICULTURE RESEARCH AND EDUCATION) PROGRAM FOR THE 13 STATES AND 2 TERRITORIES OF THE SOUTHERN REGION. EACH AGREEMENT SUPPORTS APPROXIMATELY 13 RESEARCH AND EDUCATION PROJECTS, 13 EDUCATION PROJECTS, APPROXIMATELY 20 GRADUATE STUDENT PROJECTS, APPROXIMATELY 10 ON-FARM RESEARCH PROJECTS, APPROXIMATELY 9 FARMER PROJECTS, APPROXIMATELY 8 PROFESSIONAL DEVELOPMENT PROGRAM COMPETITIVEPROJECTS,APPROXIMATELY 20 PDP MODEL STATE PROGRAM TRAINING GRANTS AND 14 MODEL STATE PROGRAM-PROGRAM ASSISTANT GRANTS. REGIONAL COMPETITIVE GRANTS PROGRAM TO HELP AGRICULTURE BECOME MORE PROFITABLE, PROTECT NATURAL RESOURCES AND THE ENVIRONMENT AND IMPROVE QUALITY OF LIFE FOR RURAL COMMUNITIES.

DATA COLLECTION

THE HIV/AIDS PARTNERSHIP: IMPACT THROUGH PREVENTION, PRIVATE SECTOR AND EVIDENCE-BASED PROGRAMMING (PIPPSE)

SOUTHEAST CENTER FOR AGRICULTURAL HEALTH AND INJURY PREVENTION-RENEWAL

SPHINGOLIPIDS IN CANCER BIOLOGY AND THERAPY

HEALTH CENTER CLUSTER

ALZHEIMER'S DISEASE CORE CENTER

MACS/WIHS COMBINED COHORT STUDY: BROOKLYN CLINICAL RESEARCH SITE (BKLYN CRS)

CSULB BUILDING BIOMEDICAL RESEARCH PROGRAM: OVERALL COMPONENT

RII TRACK-1: KENTUCKY ADVANCED MANUFACTURING PARTNERSHIP FOR ENHANCED ROBOTICS AND STRUCTURES

POWERING THE KENTUCKY BIOECONOMY FOR A SUSTAINABLE FUTURE

MIDDLE EAST NORTH AFRICA INVESTMENT INITIATIVE (MENA II) LEBANON

REDUCING TRAFFICKING AMONG CHILDREN IN SUB SAHARAN AFRICA

THE UNIVERSITY OF MISSISSIPPI RESEARCH PARK

THE SCIENCE OF DECISION MAKING: CONNECTING PEOPLE AND POLICY

NOVEL MEDICATION APPROACHES FOR SUBSTANCE ABUSE

NATIONAL CHILD WELFARE WORKFORCE INSTITUTE

SCIENCE BASED NANO-STRUCTURE DESIGN AND SYNTHESIS OF HETEROGENEOUS FUNCTIONAL MATERIALS FOR ENERGY SYSTEMS -- EFRC

TO PROVIDE SUPPORT FOR "FAMILY PLANNING AND REPRODUCTIVE HEALTH METHODS TO ADDRESS UNMET NEEDS"

CARES FUNDING FOR STUDENTS AFFECTED BY COVID-19

HEALTH CENTER CLUSTER

CSC-EARTH SYSTEM SCIENCES AND REMOTE SENSING TECHNOLOGIES - ESSRST

NORTHEASTERN CHEMICAL ENERGY STORAGE CENTER (NOCESC) -- EFRC

UNDERSTANDING MECHANISMS OF HESC SELF-RENEWAL AND CELL FATE COMMITMENT

TRADE ADJUSTMENT ASSISTANCE COMMUNITY COLLEGE AND CAREER TRAINING

IN ORDER FOR SUNY MARITIME TO BE ABLE TO RECEIVE ITS NEW TRAINING VESSEL, THE EXISTING PIER AND INFRASTRUCTURE MUST BE UPGRADED. THESE FUNDS ARE PROVIDED TO SUNY MARITIME ACADEMY TO MAKE THE UPGRADES AND IMPROVEMENTS.

HIGHER EDUCATION EMERGENCY RELIEF FUND - SUNY OLD WESTBURY

BREAKING THE CYCLE OF INTERGENERATIONAL DISADVANTAGE: NEURODEVELOPMENT AMONG PUERTO RICAN CHILDREN.

NEW AWARD DE-FE0007395 ENTITLED "APPLICATION OF A HEAT-INTEGRATED POST-COMBUSTION CARBON DIOXIDE CAPTURE SYSTEM WITH HITACHI ADVANCED SOLVENT INTO EX

A SCIENTIFIC OCEAN DRILLING COORDINATING OFFICE FOR THE US COMMUNITY -TEXAS A&M UNIVERSITY (TAMU) AND COLUMBIA UNIVERSITY (LDEO) COLLABORATIVELY PROPOSE TO FORM A SCIENTIFIC OCEAN DRILLING COORDINATING OFFICE (SODCO) TO FACILITATE U.S. SCIENTIFIC OCEAN DRILLING (SOD) GOALS. WITH AN EXPERIENCED STAFF OF ENGINEERS, SCIENTISTS, AND TECHNICAL SPECIALISTS, TAMU WILL ASSIST PRINCIPAL INVESTIGATORS WITH CREATING DRILLING PROPOSALS; IDENTIFY SUITABLE DRILLING PLATFORMS, CORING, AND LOGGING TOOLS; WORK WITH THE SCIENTIFIC COMMUNITY TO ADVANCE NEW TECHNOLOGIES; AND PLAN AND IMPLEMENT EXPEDITIONS. ACQUISITION OF CUSTOMIZED SEAGOING CONTAINERS WILL PROVIDE CRITICAL INSTRUMENTATION AND SUPPORT FOR AT-SEA DATA COLLECTION, WHILE LABORATORY FACILITIES AT THE GULF COAST REPOSITORY WILL BE AVAILABLE FOR SHORE-BASED DESCRIPTION AND MEASUREMENTS. LDEO, WITH EXPERIENCED SCIENCE, COMMUNICATIONS, AND ADMINISTRATIVE STAFF, WILL PROVIDE RESEARCH COMMUNITY SUPPORT SERVICES FOR SUCCESSFUL PLANNING AND EXECUTION OF EXPEDITIONS, INCLUDING PRE-DRILLING ACTIVITIES, PLANNING AND TRAINING WORKSHOPS, AND SCIENCE COMMUNICATIONS AND OUTREACH. SODCO WILL BE GUIDED BY A COMMUNITY ADVISORY BOARD AND TWO PANELS TO PROVIDE SAFETY AND ENVIRONMENTAL PROTECTION AND ENGINEERING DEVELOPMENT GUIDANCE. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

STRATEGIES FOR TARGETING ASTROCYTE REACTIVITY IN ALZHEIMER'S DISEASE AND RELATED DEMENTIAS - OVERALL – ABSTRACT SUMMARY THIS P01— STRATEGIES FOR TARGETING ASTROCYTE REACTIVITY IN AD AND ADRD (STAR-ADRD) ADDRESSES THE (PATHO)PHYSIOLOGIC ROLES OF REACTIVE ASTROCYTES IN ALZHEIMER’S DISEASE (AD) AND RELATED DEMENTIAS (ADRD). THOUGH HIGHLY SIGNIFICANT TO MANY DISEASE PHENOTYPES, ASTROCYTE FUNCTIONS ARE UNDER-INVESTIGATED AND HAVE YET TO BENEFIT FROM LARGE-SCALE PROGRAMMATIC SUPPORT FROM THE NIH. TO FILL THIS VOID WE HAVE ASSEMBLED A HIGHLY ACCOMPLISHED AND COLLABORATIVE TEAM FROM THE UNIVERSITY OF KENTUCKY SANDERS-BROWN CENTER ON AGING (UK- SBCOA). THE OVERARCHING GOALS OF THIS PROJECT ARE TO: (1) USE CELL-SPECIFIC TARGETING TO MODULATE DISTINCT ASPECTS OF THE REACTIVE ASTROCYTE PHENOTYPE. (2) USE CUTTING-EDGE TECHNOLOGIES TO ASSESS THE FUNCTIONAL IMPACT OF REACTIVE ASTROCYTES IN INTACT PRECLINICAL MOUSE MODELS OF AD AND ADRD PATHOLOGIES. (3) LEVERAGE UK-SBCOA AND UK- ALZHEIMER’S DISEASE RESEARCH CENTER (ADRC) RESOURCES TO VALIDATE PRECLINICAL RESULTS IN POSTMORTEM AND LIVING HUMAN SUBJECTS. AND (4) USE AN INTEGRATED DATA PIPELINE APPROACH TO ANALYZE AND INTERPRET DATA WITHIN AND ACROSS PROJECTS. THROUGH THESE AIMS WE WILL TEST THE HYPOTHESIS THAT: INTERRELATED REACTIVE ASTROCYTE PHENOTYPES DRIVE MAJOR PATHOPHYSIOLOGIC FEATURES OF DEMENTIA INCLUDING CEREBROVASCULAR DYSFUNCTION, HYPOMETABOLISM, AND IMPAIRED NEURONAL NETWORK FUNCTION AND FIDELITY. PROJECTS ARE DESIGNED AROUND A CLEAR UNDERSTANDING THAT DEMENTIA DOES NOT EXIST AS A SINGLE PATHOLOGICAL ENTITY MOST OF THE TIME, BUT RATHER IS CHARACTERIZED BY MULTIPLE BRAIN PATHOLOGIES. PROJECT 1 (ASTROCYTIC END-FEET AND VCID) WILL USE MMP9 OVEREXPRESSION/KNOCKDOWN IN A MODEL OF CEREBRAL SMALL VESSEL DISEASE TO ADDRESS ASTROCYTE ENDFEET DEGENERATION. PROJECT 2 (ASTROCYTIC INSULIN SIGNALING AND AD) WILL OVEREXPRESS/KNOCKDOWN ASTROCYTIC INSULIN RECEPTORS (IR) IN AN ASS MODEL TO STUDY THE IMPACT OF IMPAIRED ASTROCYTIC IR SIGNALING. PROJECT 3 (ASTROCYTIC GLUTAMATE TRANSPORT IN AD AND VCID) WILL OVEREXPRESS/KNOCKDOWN THE ASTROCYTIC GLUTAMATE TRANSPORTER SLC1A2 IN A MIXED ASS-VASCULAR MODEL TO ASSESS THE ROLE OF IMPAIRED GLUTAMATE TRANSPORT IN REACTIVE ASTROCYTES. PROJECT 4 (ASTROCYTIC KATP CHANNELS IN LATE+HS) WILL OVEREXPRESS/ELIMINATE ASTROCYTIC ABCC9/SUR2 IN A MODEL OF LATE + HIPPOCAMPAL SCLEROSIS TO ASSESS THE ROLE OF KATP CHANNELS. FOUR CORES WILL SUPPORT AND FURTHER INTEGRATE OUR PROJECTS. CORE B: ANIMAL VASCULAR-METABOLIC-NEURAL NETWORK (VMN) WILL ASSESS CEREBROVASCULAR, METABOLIC, AND NEURAL NETWORK PROPERTIES IN MICE USING TWO-PHOTON MICROSCOPY, MRI/MRS, MICROELECTRODE ARRAY NEURO- CHEMISTRY, AND ELECTROPHYSIOLOGY. CORE C: HUMAN CONSULTATION-BIOSAMPLES-BIOMARKERS (CBB) WILL VALIDATE RESULTS IN MICE USING WELL CHARACTERIZED AUTOPSY TISSUE, MRI, EEG, AND FLUID BIOMARKER DATA FROM HUMANS. AND CORE D: DATA MANAGEMENT AND BIOSTATISTICS WILL ESTABLISH A DATA PIPELINE FOR EFFICIENT CATEGORIZATION, TRANSFORMATION, AND STATISTICAL ANALYSIS OF COMPLEX RELATIONSHIPS BETWEEN ASTROCYTE INTERVENTIONS AND ENDPOINT MEASURES, WITHIN AND BETWEEN PROJECTS. FINALLY, AN ADMINISTRATIVE CORE (CORE A) WILL PROVIDE LEADERSHIP, COORDINATION, INTEGRATION, AND ADMINISTRATIVE STRUCTURE, SO THAT THE P01 GOALS ARE ACHIEVED.

THE NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION (NOAA) AWARD RECIPIENT IS THE RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK - THE CITY COLLEGE. THIS COOPERATIVE SCIENCE CENTER (CSC), FUNDED THROUGH NOAA OFFICE OF EDUCATION, EDUCATIONAL PARTNERSHIP PROGRAM WITH MINORITY SERVING INSTITUTIONS (EPP/MSI) IS FOCUSED ON EARTH SYSTEMS SCIENCE AND REMOTE SENSING TECHNOLOGIES ALIGNED WITH THE NOAA MISSION. THE ACADEMIC HOME OF THE CENTER IS THE GROVE SCHOOL OF ENGINEERING AT THE CITY COLLEGE OF NEW YORK. THIS IS THE SECOND FIVE-YEAR AWARD CYCLE FOR THE NOAA CENTER FOR EARTH SYSTEM SCIENCE AND REMOTE SENSING TECHNOLOGIES 9CESSRST-II). THE PURPOSE OF THIS EPP/MSI CSC AWARD IS TO ENHANCE DEVELOPING STUDENTS THROUGH EDUCATION, AND WITH INTERNSHIPS AT NOAA, TO BE A DIVERSE CADRE OF NEW PROFESSIONALS, REPRESENTATIVE OF THE NATION'S DEMOGRAPHY, AND ELIGIBLE CANDIDATES FOR THE FUTURE NOAA MISSION ENTERPRISE WORKFORCE. CESSRST-II IS TO BE FUNDED ANNUALLY, BASED ON SATISFACTORY PERFOR

HEALTH CENTER CLUSTER

CENTER OF BIOMEDICAL RESEARCH EXCELLENCE IN PHARMACEUTICAL RESEARCH AND INNOVATION

AI INSTITUTE FOR TRANSFORMING EDUCATION FOR CHILDREN WITH SPEECH AND LANGUAGE PROCESSING CHALLENGES -IT IS ESTIMATED THAT MORE THAN 3.4 MILLION CHILDREN NEED SPEECH AND LANGUAGE RELATED SERVICES IN THE US SCHOOL SYSTEM, YET THERE ARE LESS THAN SIXTY-ONE THOUSAND SPEECH-LANGUAGE PATHOLOGISTS (SLPS) TO SERVE THEM. THE COVID-19 PANDEMIC HAS FURTHER EXACERBATED THIS GAP, MAKING IT ALMOST IMPOSSIBLE FOR SLPS TO PROVIDE INDIVIDUALIZED SERVICES FOR CHILDREN. THE AI INSTITUTE FOR TRANSFORMING EDUCATION FOR CHILDREN WITH SPEECH AND LANGUAGE PROCESSING CHALLENGES AIMS TO CLOSE THIS GAP BY DEVELOPING ADVANCED AI TECHNOLOGIES TO SCALE SLPS' AVAILABILITY AND SERVICES SUCH THAT NO CHILD IN NEED OF SPEECH AND LANGUAGE SERVICES IS LEFT BEHIND. TOWARDS THIS END, THE INSTITUTE PROPOSES TO DEVELOP TWO NOVEL AI SOLUTIONS: (1) THE AI SCREENER TO ENABLE UNIVERSAL EARLY SCREENING FOR ALL CHILDREN, AND (2) THE AI ORCHESTRATOR TO WORK WITH SLPS TO PROVIDE INDIVIDUALIZED INTERVENTIONS FOR CHILDREN WITH THEIR FORMAL INDIVIDUALIZED EDUCATIONAL PLAN (IEP). IN DEVELOPING THESE SOLUTIONS, THE INSTITUTE WILL ADVANCE FOUNDATIONAL AI TECHNOLOGIES, ENHANCE UNDERSTANDING OF CHILDREN'S SPEECH AND LANGUAGE DEVELOPMENT, SERVE AS A NEXUS POINT FOR SPECIAL EDUCATION STAKEHOLDERS, AND REPRESENT A FUNDAMENTAL PARADIGM SHIFT IN HOW SLPS SERVE CHILDREN IN NEED OF ABILITY BASED SPEECH AND LANGUAGE SERVICES. THE AI SCREENER WILL BE INITIALLY DEPLOYED IN EARLY CHILDHOOD CLASSROOMS AND WILL ANALYZE VIDEO AND AUDIO STREAMS OF CHILDREN'S CLASSROOM INTERACTIONS, DERIVE CONVENTIONAL SPEECH AND LANGUAGE MEASURES USED BY SLPS, AND ASSESS NOVEL AND HARD TO OBTAIN AUTOMATICITY MEASURES. THE AI ORCHESTRATOR IS A SUPERSET OF THE AI SCREENER WITH ITS MAIN APPLICATION IN THE PUBLIC SCHOOL CLASSROOMS. IT WILL HELP SLPS TO ADMINISTER A WIDE RANGE OF EVIDENCE-BASED INTERVENTIONS AND ASSESS THEIR EFFECTS ON MEETING CHILDREN'S INDIVIDUAL IEP LEARNING TARGETS. AT THE CORE OF THE ORCHESTRATOR IS A ROBUST MULTI-AGENT REINFORCEMENT LEARNING FRAMEWORK THAT CAN EVALUATE THE POTENTIAL BENEFITS OF DIFFERENT INTERVENTION PRACTICES AND RECOMMEND THOSE MOST APPROPRIATE FOR EACH CHILD. BOTH SOLUTIONS WILL PUSH SIGNIFICANT ADVANCES IN SELF-SUPERVISED LEARNING TO ADDRESS SPARSE AND NOISY DATA ISSUES, MULTIMODALITY PERCEPTION, LEARNING MATERIAL REWRITING AND ENRICHMENT, AND EDGE AI FOR REAL TIME PROCESSING. THE INSTITUTE WILL DEVELOP HUMAN CENTERED AI DESIGN METHODOLOGIES TO EMBODY THE SOLUTIONS IN A FORM APPROPRIATE FOR CHILDREN?S LEARNING. EDUCATION RESEARCH AND THE LEARNING SCIENCES WILL INFORM THE INITIAL PROTOTYPING AND VALIDATION, AND WILL DERIVE VALUABLE INSIGHTS FROM THE FIELD DEPLOYED SOLUTIONS. THE NATIONAL CENTER FOR SPECIAL EDUCATION RESEARCH AT THE INSTITUTE OF EDUCATION SCIENCES OF THE US DEPARTMENT OF EDUCATION IS PARTNERING WITH NSF TO PROVIDE FUNDING FOR THE INSTITUTE. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

RISE PROGRAM-HUNTER COLLEGE

OVERDOSE DATA TO ACTION - KENTUCKY CONTINUES TO BE PLAGUED BY THE DRUG OVERDOSE EPIDEMIC. IN 2021, KENTUCKY HAD AGE-ADJUSTED DRUG OVERDOSE MORTALITY RATE OF 53.6 DEATHS PER 100,000 RESIDENTS, 3RD HIGHEST STATE IN THE UNITED STATES. (CDC NCHS, 2023). SINCE 2018, KENTUCKY THE AGE-ADJUSTED DRUG OVERDOSE MORTALITY RATE HAS INCREASED 81%. (STEEL & MIRZAIAN, 2022). THE DRUG OVERDOSE MORTALITY BURDEN IS HIGH IN KENTUCKY AS IS DRUG OVERDOSE MORBIDITY. IN 2021, THE AGE-ADJUSTED RATE OF DRUG OVERDOSES TREATED IN KENTUCKY EMERGENCY DEPARTMENT (ED) WAS 308.2/100,000 RESIDENTS - 8 PERCENT INCREASE SINCE 2018. RATES OF ED VISITS FOR ANY REASON WITH A CO-OCCURRING SUBSTANCE USE DISORDER DIAGNOSIS HAS INCREASED NEARLY 5% FROM 1002.1 IN 2018 TO 1049.1/100,000 IN 2019. (KIPRC, 2022). THE BURDEN OF OVERDOSE IS FELT DISPROPORTIONATELY. BLACK KENTUCKIANS HAVE HIGHER AGE-ADJUSTED MORTALITY (58.5/100,000) AND MORBIDITY (359.2/100,000) THAN WHITE KENTUCKIANS (MORTALITY (53.5/100,000) AND MORBIDITY (324/100,000)). NINE OF THE 10 COUNTIES WITH THE HIGHEST AGE-ADJUSTED MORTALITY RATES ARE RURAL COUNTIES, AND 9 OF 10 COUNTIES WITH THE HIGHEST AGE-ADJUSTED MORBIDITY RATES ARE ALSO RURAL. TO REDUCE THESE RATES, THERE MUST BE MULTIPRONGED APPROACHES IMPLEMENTED: 1) IDENTIFICATION AND MONITORING OF SUBSTANCE USE DISORDERS (SUD) AND DRUG OVERDOSES THROUGH COMPREHENSIVE SURVEILLANCE; AND 2) ENHANCING DEVELOPMENT, IMPLEMENTATION, AND EVALUATION OF EVIDENCE-INFORMED, EVIDENCE-BASED, AND PROMISING PREVENTION PROGRAM AND POLICY STRATEGIES. THE KENTUCKY INJURY PREVENTION AND RESEARCH CENTER (KIPRC), AS A BONA FIDE AGENT FOR THE KENTUCKY DEPARTMENT OF PUBLIC HEALTH, WILL COLLABORATE WITH STATE, UNIVERSITY, AND COMMUNITY PARTNERS TO IMPLEMENT SURVEILLANCE AND PREVENTION STRATEGIES. SURVEILLANCE STRATEGIES INCLUDE ENHANCING THE SURVEILLANCE INFRASTRUCTURE; THE TIMELY ANALYSIS OF DRUG OVERDOSE ED ENCOUNTERS AND FATAL DRUG OVERDOSES USING MULTIPLE DATA SOURCES; BIO SURVEILLANCE OF DRUG INVOLVEMENT IN NON-FATAL OVERDOSES; AND DATA LINKAGES TO CRIMINAL JUSTICE DATA AT THE INDIVIDUAL LEVEL; HARM REDUCTION DATA TEMPORALLY TO OVERDOSE DATA, AND OPTIONAL STRATEGIES OF BIOSURVEILLANCE AND DATA LINKAGE. KIPRC'S PREVENTION STRATEGIES INCLUDE EDUCATING CLINICIANS ON BEST PAIN MANAGEMENT PRACTICES USING CDC PRESCRIBING GUIDELINES; TRAINING CLINICIANS ON OUD (OPIOID USE DISORDER) AND STIMULANT USE DISORDER (STUD) PATIENT STANDARDS OF CARE; SUPPORTING ED LINKAGE TO CARE WITH NAVIGATORS; EXPANDING PRESCRIPTION DRUG MONITORING PROGRAM DATA SHARING; DEVELOPING PUBLIC HEALTH (PH)/PUBLIC SAFETY (PS) PARTNERSHIPS; IMPROVING PH/PS DATA SHARING; DEVELOPING PH/PS OUD AND STUD TRAININGS; USING HARM REDUCTION (HR) NAVIGATORS TO CONNECT PEOPLE TO SERVICES; DEVELOPING A STATEWIDE HARM REDUCTION SERVICES RESOURCE LIST; HOSTING ANNUAL IN-PERSON HR SERVICES TRAINING; USING RECOVERY NAVIGATORS TO LINK VULNERABLE INDIVIDUALS TO AVAILABLE SUD TREATMENT WITH FINDHELPNOWKENTUCKY (FHNKY) AND RECOVERY HOUSING WITH FINDRECOVERYHOUSINGNOWKENTUKCKY(FRHNKY); DEVELOPING A RECOVERY MONITORING SYSTEM; DEVELOPING A RECOVERY RESIDENT MANAGEMENT SYSTEM; AND DEVELOPING A COMPREHENSIVE RESOURCES SECTION WITHIN FRHNKY. KIPRC HOPES TO REDUCE OVERDOSE MORTALITY AND MORBIDITY, IMPROVE THE STANDARD OF CARE AND LINKAGE TO CARE FOR INDIVIDUALS WITH SUD, AND INCREASE ACCESS TO RECOVERY SUPPORT THROUGH PREVENTION EFFORTS GUIDED BY ENHANCED SURVEILLANCE.

CALIFORNIA EMERGING INFECTIONS PROGRAM

TRANSPORT - THE TRANSLATIONAL PROGRAM OF HEALTH DISPARITIES RESEARCH TRAINING

ECOG STATISTICAL OFFICE DATA MANAGEMENT GRANT

CENTRAL APPALACHIAN REGION EDUCATIONAL RESEARCH CENTER OCCUPATIONAL SAFETY CORE

PROTOTYPE STUDY OF A NEW CENTRAL DRIFT CHAMBER FOR CLEO II & INVESTIGATION OF THE T PARADOX USING CLEO II OUTSTANDING JUNIOR INVESTIGATOR PROGRAM.

NSF I-CORPS HUB: NEW YORK REGION

FREDONIA'S RESPONSE TO THE CARES ACT: HIGHER EDUCATION EMERGENCY RELIEF FUND (INSTITUTIONAL)

SREL

CENTER FOR CELLULAR METABOLISM RESEARCH IN OKLAHOMA - ALTERED CELLULAR METABOLISM CONTRIBUTES TO THE PATHOGENESIS OF MANY COMMON DISEASES, SUCH AS CARDIOVASCULAR DISEASE, CANCER, DIABETES, AND AUTOIMMUNE DISORDERS, WHICH ARE PREVALENT IN OKLAHOMA. HOWEVER, METABOLISM- RELATED RESEARCH RESOURCES AND INFRASTRUCTURE ARE CURRENTLY INSUFFICIENT AND SCATTERED IN OKLAHOMA. TO ADDRESS THESE DEFICIENCIES, THIS CENTER FOR CELLULAR METABOLISM RESEARCH IN OKLAHOMA (CMRO) PHASE I COBRE WILL CREATE AND NURTURE EXCELLENCE IN CELLULAR METABOLISM IN OKLAHOMA. THE CMRO IS LOCATED AT THE OKLAHOMA MEDICAL RESEARCH FOUNDATION (OMRF), A LEADING BIOMEDICAL RESEARCH INSTITUTE. THE CENTRAL FOCUS OF THE CMRO IS TO SUPPORT FIVE NEW ASSISTANT MEMBER-LEVEL FACULTY (EQUIVALENT TO TENURE-TRACK ASSISTANT PROFESSOR AT A RESEARCH UNIVERSITY) AS PROJECT LEADERS FROM THREE DIFFERENT OMRF RESEARCH PROGRAMS: CARDIOVASCULAR BIOLOGY (CVB), AGING & METABOLISM (AM), AND ARTHRITIS & CLINICAL IMMUNOLOGY (ACI). THESE NEW JUNIOR INVESTIGATORS ARE THE FOUNDATION FOR EXPANSION AND UNIFICATION OF CELLULAR METABOLISM RESEARCH. THEY WILL RECEIVE AN APPROPRIATE LEVEL AND FORM OF MULTIDISCIPLINARY MENTORING FROM EXPERIENCED AND COMPETITIVE SCIENTISTS. THE CMRO COBRE AIMS TO DEVELOP A CRITICAL MASS OF INVESTIGATORS WHO CAN SECURE EXTERNAL FUNDING TO SUPPORT THEIR RESEARCH WHILE CREATING A NEW, EXCITING, MULTIDISCIPLINARY, AND COLLABORATIVE ENVIRONMENT FOR SUSTAINED COMPETITIVE RESEARCH ON CELLULAR METABOLISM IN OKLAHOMA, WHICH WILL BE ACHIEVED THROUGH FIVE AIMS: 1) SUPPORT FIVE PROMISING YOUNG PROJECT LEADERS TO SCIENTIFIC INDEPENDENCE THROUGH INCORPORATION OF CELLULAR METABOLISM RESEARCH IN THEIR LABS; 2) PROMOTE NOVEL MULTIDISCIPLINARY RESEARCH FOCUSING ON CELLULAR METABOLISM THROUGH MENTORING THE JUNIOR PROJECT LEADERS FROM THREE DIFFERENT OMRF RESEARCH PROGRAMS; 3) INTEGRATE EXISTING AND NEW RESOURCES THROUGH CORE FACILITIES THAT SUPPORT CELLULAR METABOLISM RESEARCH; 4) PROMOTE AN ENVIRONMENT THAT SUPPORTS THE SUCCESS AND DEVELOPMENT OF AN INDEPENDENT SUSTAINABLE CENTER. THE COBRE SUPPORT WILL BE CRITICAL TO CREATE A NEW, MULTIDISCIPLINARY AND COLLABORATIVE ENVIRONMENT FOR SUSTAINED COMPETITIVE RESEARCH ON CELLULAR METABOLISM IN OKLAHOMA.

THERAPEUTICS TARGETING FILOVIRAL INTERFERON-ANTAGONIST AND REPLICATION FUNCTIONS

RURAL OPPORTUNITIES THROUGH LITERACY, OBSERVATION, TUTORING, AND STEM (ROOTS)

PROJECT RESEARCH-BASED STRATEGIES AND ARTIFICIAL INTELLIGENCE FOR SCHOOL ENHANCEMENT:TURNING AROUND SCHOOLS (RAISE)

NORTHEAST CENTER FOR CHEMICAL ENERGY STORAGE (NECCES)

ESC INSTITUTIONAL CARES AID

TAS::89 0211::TAS RECOVERY SITE CHARACTERIZATION OF PROMISING GEOLOGIC FORMATIONS FOR CO2 STORAGE FOR NEW AWARD ENTITLED, "RECOVERY ACT: GEOLOGICAL C

KNOWLEDGE ACQUISITION AND TRANSFORMATION EXPANSION (KATE)

CROSS-INSTITUTIONAL COLLABORATION AND REIMAGINING TOWARD EQUITY, ACCESS, AND TEACHER EFFECTIVENESS: EXPANDING AND SUSTAINING PROJECT CREATE

CALIFORNIA ELC 2014

UNIVERSITY OF KENTUCKY ALZHEIMER'S DISEASE RESEARCH CENTER - PROJECT SUMMARY/ABSTRACT: OVERALL THE UNIVERSITY OF KENTUCKY ALZHEIMER’S DISEASE RESEARCH CENTER (UK-ADRC) IS AN EXPERIENCED AND COLLABORATIVE CENTER THAT HAS FACILITATED PIONEERING RESEARCH IN AD AND RELATED DEMENTIAS (ADRD) SINCE ITS INCEPTION IN 1985. OUR PRINCIPAL MISSION IS TO SERVE AS THE FOCAL POINT FOR ALL AD-RELATED ACTIVITIES AT UK AND THIS REGION OF THE UNITED STATES, BY PROVIDING AN ENVIRONMENT AND CORE RESOURCES THAT CATALYZE INNOVATIVE RESEARCH, OUTREACH, EDUCATION, AND CLINICAL PROGRAMS. OUR SIGNATURE RESOURCES INCLUDE: 1) A COGNITIVELY NORMAL GROUP OF ~500 SUBJECTS FOLLOWED LONGITUDINALLY, TOGETHER WITH ~300 ADDITIONAL SUBJECTS WHO TRANSITIONED TO MCI OR DEMENTIA, AND ALL COMMITTED TO BRAIN AUTOPSY UPON DEATH; 2) A STRONG AUTOPSY PROGRAM WITH CLINICAL- NEUROPATHOLOGICAL CORRELATIONS AND SHORT POSTMORTEM INTERVAL RESEARCH MATERIAL; 3) A MATURING PROGRAM STUDYING THE EARLY PRECLINICAL BIOLOGICAL EMERGENCE OF MIXED PATHOLOGIES AND HOW THEY CONTRIBUTE TO LATE LIFE DEMENTIA STATES, WITH AN INCREASING FOCUS ON ANTEMORTEM BIOMARKER COLLECTION; 4) AN INTEGRATED CENTRALIZED DATABASE AND INNOVATIVE BIOSTATISTICAL EXPERTISE TO CHARACTERIZE CLINICAL AND BIOLOGICAL TRANSITIONS; 5) A SUCCESSFUL AND CLOSE PARTNERSHIP WITH THE AFRICAN-AMERICAN COMMUNITY AND INCREASED PARTICIPATION OF UNDERREPRESENTED INDIVIDUALS IN OUR LONGITUDINAL COHORT AND ADRC-AFFILIATED RESEARCH STUDIES AND CLINICAL TRIALS; AND 6) A RICH, INTERDISCIPLINARY TRAINING ENVIRONMENT THAT PROVIDES MULTI-FACETED EDUCATIONAL OPPORTUNITIES FOR RESEARCHERS, HEALTHCARE PROVIDERS, AND OUR COMMUNITY PARTNERS. THE OVERARCHING THEME OF THE UK-ADRC IS: TRANSITIONS FROM NORMAL TO LATE-LIFE MULTI-ETIOLOGY DEMENTIA. OUR WELL-CHARACTERIZED, LONGITUDINAL COHORT AND HISTORICALLY STRONG NEUROPATHOLOGY PROGRAM FOCUSED ON NORMAL AGING, PRECLINICAL DISEASE STATES AND EARLY COGNITIVE TRANSITIONS HAVE BEEN CENTRAL TO OUR SUCCESS IN DEFINING EARLY PATHOGENIC MECHANISMS UNDERLYING THE TRANSITIONS FROM NORMAL COGNITIVE AGING TO IMPAIRMENT. IN ADDITION, THESE EFFORTS HAVE BEEN A DRIVING FORCE IN OUR RECOGNITION OF THE HETEROGENEITY AND MULTIPLE PATHOLOGIES THAT CHARACTERIZE LATE-LIFE DEMENTIA. THE UK-ADRC WILL CONTINUE TO LEVERAGE OUR STRENGTHS TO ENHANCE OUR IMPACT AND “CENTERNESS” BY OUR FOCUS ON THIS OVERARCHING THEME, AND THE PURSUIT OF FOUR OVERALL SPECIFIC AIMS. AIM 1. FACILITATE AND ENHANCE BASIC, TRANSLATIONAL AND CLINICAL RESEARCH IN AD AND RELATED DEMENTIAS. AIM 2. PROVIDE THE NECESSARY RESOURCES AND INTERACTIVE ENVIRONMENT TO SUPPORT AND CREATE NEW OPPORTUNITIES FOR INNOVATIVE RESEARCH. AIM 3. MAINTAIN AND GROW EDUCATIONAL OPPORTUNITIES AND COMMUNITY PARTNERSHIPS TO PROMOTE AWARENESS, INCREASE PARTICIPATION IN RESEARCH, AND PROVIDE AN INNOVATIVE AND INTERDISCIPLINARY TRAINING ENVIRONMENT. AIM 4. CONTRIBUTE TO THE NATIONAL EFFORTS AND COLLABORATIVE ACTIVITIES WITH OTHER CENTERS, PROGRAMS AND GROUPS TO ADVANCE AD/ADRD RESEARCH, EDUCATION, AND CARE.

BASIC AND TRANSLATIONAL RESEARCH CENTER FOR REDUCING HEALTH DISPARITIES

MID-SCALE RI-1 (M1:IP): EDUCELAB: INFRASTRUCTURE FOR NEXT-GENERATION HERITAGE SCIENCE

RESOURCE FOR INTEGRATED GLYCOTECHNOLOGY

CALIFORNIA HOSPITALS COVID-19 PREPAREDNESS AND RESPONSE PROGRAM

GEAR-UP

SHARED PHARMACOTHERAPEUTIC STRATEGIES FOR CANNABINOID & OPIOID USE DISORDERS

NOAA-COOPERATIVE REMOTE SENSING SCIENCE AND TECHNOLOGY (CREST) CENTER

AN ANIMAL BIOSAFETY LEVEL 3 LABORATORY FOR STONY BROOK UNIVERSITY

BEING A PPP AGREEMENT WITH A CEILING OF $8,500,000 AND INITIAL OBLIGATION OF $260,000

NEVADA CANCER RESEARCH FOUNDATION-NCI COMMUNITY ONCOLOGY RESEARCH PROGRAM

CENTER FOR APPALACHIAN RESEARCH IN ENVIRONMENTAL SCIENCES

ENABLE MIDDLE-GRADERS WITH POWERFUL READING COMPREHENSION (EMPOWER)

TRANSFORMING KENTUCKY'S NEW ECONOMY

SC IDEA NETWORK OF BIOMEDICAL RESEARCH EXCELLENCE

OP EARLY INTERVENTION SVCS W/RESPECT TO HIV DISEASE

NATIONAL CENTER FOR BIOMEDICAL GLYCOMICS

CENTER OF RESEARCH IN OBESITY AND CARDIOVASCULAR DISEASE (1P20 RR021954-01A1)

PROTEIN-GLYCAN INTERACTIONS IN THE VASCULAR SYSTEM

FROM QUARKS TO NUCLEI

KENTUCKY CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE

MISSOURI ENTERPRISE

CDART - CENTER FOR DRUG ABUSE RESEARCH TRANSLATION

COORDINATING CENTER FOR RESEARCH AND TRAINING TO PROMOTE THE HEALTH OF PEOPLE WIT

NEW YORK SERVICE OPPORTUNITIES TO ACCESS RECOVERY SUCCESSFULLY (NY SOARS)

VALUE-BASED MEDICAL STUDENT EDUCATION TRAINING PROGRAM

THIS EDA INVESTMENT SUPPORTS THE NEW ENERGY NEW YORK COALITION, LED BY THE STATE UNIVERSITY OF NEW YORK (SUNY) AT BINGHAMTON, WITH ACCELERATING BATTERY TECHNOLOGY INNOVATION IN NEW YORK BY TRANSFORMING NEW YORK'S SOUTHERN TIER INTO A GLOBAL HUB OF ENERGY STORAGE MANUFACTURING. THE PROJECTS FUNDED AS PART OF THIS AWARD INCLUDE BUILDING A LITHIUM-BASED BATTERY DEVELOPMENT MANUFACTURING FACILITY, THE BATTERY-NY CENTER, WHICH WILL PROVIDE TESTING, CERTIFICATION, AND SCALE-UP CAPACITY FOR NEW PRODUCTS AND COMPANIES. COMPLEMENTARY PROJECT LEADS WILL WORK WITH EXISTING MANUFACTURERS TO ESTABLISH THEM AS ELIGIBLE SUPPLIERS FOR ENERGY PRODUCTS; AND EXPAND WORKFORCE TRAINING PROGRAMS TO ADDRESS NEEDS OF THE GROWING CLUSTER. ONCE IMPLEMENTED, THE INVESTMENT WILL HELP DEVELOP AND STRENGTHEN REGIONAL INDUSTRY CLUSTERS - ALL WHILE EMBRACING ECONOMIC EQUITY, CREATING GOOD-PAYING JOBS, AND ENHANCING U.S. COMPETITIVENESS GLOBALLY.

XD METRICS SERVICE (XMS)

CALIFORNIA EMERGING INFECTIONS PROGRAM

RII TRACK-1: CLIMATE RESILIENCE THROUGH MULTIDISCIPLINARY BIG DATA LEARNING, PREDICTION & BUILDING RESPONSE SYSTEMS (CLIMBS) -THE COMMONWEALTH OF KENTUCKY FACES MOUNTING THREATS FROM GLOBAL ENVIRONMENTAL CHANGE AND NATURAL HAZARDS, INCLUDING EXTREME WEATHER EVENTS, FLOODS, DROUGHTS, AND LANDSLIDES. THIS CLIMATE RESILIENCE THROUGH MULTIDISCIPLINARY BIG DATA LEARNING, PREDICTION & BUILDING RESPONSE SYSTEMS (CLIMBS) PROJECT AIMS TO ADVANCE THE FIELDS OF CLIMATE SCIENCE, GEOHAZARDS ENGINEERING, AND DISASTER MANAGEMENT TO FACILITATE IMPROVED SUSTAINABILITY, RESILIENCE, AND ADAPTATIVE ENGINEERING TO CLIMATE CHANGE. CLIMBS RESEARCH WILL TARGET UNDERSERVED COMMUNITIES IN EASTERN KENTUCKY, AN APPALACHIAN REGION THAT IS ESPECIALLY VULNERABLE TO CLIMATE CHANGE. THE RESEARCH WILL PRODUCE A HOLISTIC UNDERSTANDING OF CLIMATE CHANGE PROCESSES IN KENTUCKY ACROSS MULTIPLE SPATIAL AND TEMPORAL SCALES, DETERMINE THE INFLUENCE OF CLIMATE CHANGE ON GEOHAZARDS THAT THREATEN THE COMMONWEALTH, AND ESTABLISH AN ENHANCED TOOLS AND TECHNOLOGY FRAMEWORK FOR CLIMATE CHANGE MITIGATION AND COMMUNITY DISASTER RESPONSE. RESULTS OF THIS RESEARCH WILL BENEFIT KENTUCKY'S KEY INDUSTRIES OF MANUFACTURING, DATA ANALYTICS, ENERGY TRANSITION, AND ENGINEERING, AND HELP TRAIN A SCIENCE AND ENGINEERING WORKFORCE THAT WILL ALLOW SMALLER INDUSTRIES TO FLOURISH. CLIMBS WILL BE ADMINISTERED BY THE UNIVERSITY OF KENTUCKY IN COLLABORATION WITH SEVEN OTHER INSTITUTIONS: UNIVERSITY OF LOUISVILLE, EASTERN KENTUCKY UNIVERSITY, NORTHERN KENTUCKY UNIVERSITY, WESTERN KENTUCKY UNIVERSITY, MOREHEAD STATE UNIVERSITY, MURRAY STATE UNIVERSITY, AND THOMAS MORE COLLEGE. CLIMBS SEEKS TO ADDRESS MAJOR KNOWLEDGE GAPS THAT SURROUND: (I) CLIMATE CHANGE PROCESSES AFFECTING KENTUCKY; (II) PATTERNS IN CLIMATE CHANGE IMPACTS; (III) CONTROLS ON SEVERE WEATHER AND EXTREME EVENTS; (IV) CLIMATE TRIGGERS, THRESHOLDS, AND FEEDBACKS THAT RESULT IN FLOOD AND LANDSLIDE HAZARDS; AND (V) CLIMATE-SMART SUSTAINABLE DESIGN AND RESILIENCE ENGINEERING IN THE BUILT ENVIRONMENT. TO ADDRESS THESE ISSUES, CLIMBS WILL ACQUIRE THE CONTEMPORARY ATMOSPHERIC AND PALEOENVIRONMENTAL DATA NEEDED TO ASSESS THE CAUSES, PATTERNS, AND CHARACTERISTICS OF REGIONAL CLIMATE DYNAMICS (TO INCLUDE EXTREME WEATHER) ACROSS SPACE AND TIME, AS WELL AS FACILITATE PREDICTIONS FOR THE IMPACTS OF CLIMATE CHANGE ON KENTUCKY'S CRITICAL ZONE AND WATER RESOURCES. RESEARCHERS WILL PURSUE INTEGRATIVE, LONG-TERM ENVIRONMENTAL MONITORING EXPERIMENTS TO DEVELOP THE BIG DATA AND CYBERINFRASTRUCTURE NEEDED TO QUANTIFY THE PROCESSES, FEEDBACKS, AND THRESHOLD CONDITIONS THAT TRIGGER FLOODS AND LANDSLIDES, AND ESTABLISH INSTRUMENTED WATERSHEDS AND HILLSLOPE MONITORING SITES. INITIAL MONITORING SITES WILL BE DEPLOYED IN SOCIO-ECONOMICALLY VULNERABLE AREAS OF EASTERN KENTUCKY, TO BRIDGE WITH PROJECT ELEMENTS DESIGNED TO IMPROVE EDUCATION AND OUTREACH IN APPALACHIA. ADDITIONALLY, CLIMBS WILL ANALYZE KENTUCKY'S BUILT ENVIRONMENT AND SOCIO-BEHAVIORAL SYSTEMS, AND USE BIG DATA, ARTIFICIAL INTELLIGENCE/MACHINE LEARNING, AND COMPUTATIONAL TOOLS TO EVALUATE VULNERABILITIES TO CLIMATE CHANGE AND IMPROVE REAL-TIME DISASTER DETECTION, WARNING SYSTEMS, AND THE RESPONSE TOOLKIT. TEN NEW FACULTY HIRES ARE PLANNED IN THE FIRST THREE YEARS OF THE PROJECT. THE CORE RESEARCH PROGRAM IS WELL INTEGRATED WITH EDUCATION, WORKFORCE DEVELOPMENT, AND DIVERSITY PLANS THAT SPAN ACADEMIC, FEDERAL, COMMONWEALTH, AND PRIVATE SECTORS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

THE OVERALL OBJECTIVE OF USAID EMPOWERED COMMUNITIES ACTIVITY IS TO ACHIEVE BETTER HEALTH AND NUTRITIONAL OUTCOMES THROUGH IMPROVED COMMUNITY OWNERSHIP OF HEALTH AND STRENGTHENED SOCIAL ACCOUNTABILITY SYSTEMS AND PLATFORMS. THE ACTIVITY WILL BE PRIMARILY FUNDED WITH FAMILY PLANNING, AND MATERNAL AND CHILD HEALTH FUNDING. THEREFORE, ALL EXPECTED RESULTS AND PROPOSED INTERVENTIONS SHOULD CONTRIBUTE TO THE BETTERMENT OF THE LIVES OF WOMEN, CHILDREN, YOUTH AND MEN ULTIMATELY, IMPROVED REPRODUCTIVE, MATERNAL, NEWBORN, CHILD AND ADOLESCENT HEALTH AND NUTRITION (RMNCAH-N) OUTCOMES.

FREDONIA'S RESPONSE TO THE CARES ACT: HIGHER EDUCATION EMERGENCY RELIEF FUND

BIOMEDICAL INNOVATIONS FOR PARKINSON'S DISEASE & NEURODEGERATIVE CONDITIONS

EVALUATION OF SAFETY AND PHARMACOKINETICS OF NALTREXONE IMPLANT - NEW MEDICATION TREATMENT APPROACHES ARE NEEDED TO HELP ADDRESS THE SEVERE EPIDEMIC OF OPIOID USE DISORDER (OUD) AND OPIOID OVERDOSE DEATHS IN THE US. CURRENTLY AVAILABLE MEDICATIONS, METHADONE, BUPRENORPHINE, AND EXTENDED RELEASE INJECTION NALTREXONE (XR-NTX; TRADE NAME: VIVITROL), ARE HIGHLY EFFICACIOUS, BUT THEIR EFFECTIVENESS IN PRACTICE IS LIMITED BY POOR ADHERENCE, WITH MANY PATIENTS STOPPING TREATMENT PREMATURELY AND RELAPSING. THE GOAL OF THIS PROPOSAL IS TO DEVELOP AN INNOVATIVE LONG ACTING SUBCUTANEOUS IMPLANTED FORMULATION OF NALTREXONE, THE O’NEIL LONG-ACTING NALTREXONE IMPLANT (OLANI), TOWARDS FDA APPROVAL. EXPECTED TO PRODUCE NALTREXONE BLOOD LEVELS SUFFICIENT TO BLOCK THE EFFECTS OF OPIOIDS FOR 6 MONTHS AFTER IMPLANT, OLANI CIRCUMVENTS THE NEED FOR ADHERENCE TO MONTHLY INJECTIONS WITH XR-NTX, AND COULD REPRESENT AN IMPORTANT NEW ADDITION TO THE MEDICAL ARMAMENTARIUM FOR TREATMENT OF OUD. THE OLANI HAS BEEN IN DEVELOPMENT BY AN AUSTRALIAN COMPANY GO MEDICAL FOR 20 YEARS WITH SEVERAL PROTOTYPES EVALUATED IN CONTROLLED CLINICAL TRIALS AND USED CLINICALLY IN AUSTRALIA. THE CURRENT FORMULATION HAS HIGHER DRUG LOADING AND A BETTER RELEASE PROFILE AND IS MANUFACTURED IN A GMP FACILITY. IT HAS BEEN USED CLINICALLY IN OVER 800 PATIENTS, GIVING CONFIDENCE THAT THE PRODUCT CAN BE SUCCESSFULLY DEVELOPED IN THE US. GO MEDICAL AND THE CURRENT TEAM OF INVESTIGATORS MET WITH THE FDA TO CHART A DEVELOPMENT PATH TOWARDS A NEW DRUG APPLICATION (NDA) VIA THE 505 B(2) PATHWAY WITH VIVITROL AS A COMPARATOR PRODUCT. AN APPLICATION FOR AN IND (# 134996) IS UNDER REVIEW BY THE FDA. THIS PROPOSAL SEEKS NIDA’S SUPPORT UNDER THE UG3/UH3 MECHANISM TO CONDUCT THE STUDIES RECOMMENDED BY THE FDA FOR THE 505 B(2) PATHWAY TO APPROVAL. UNDER THE UG3 PHASE, STUDY 1 WILL EVALUATE LOCAL TISSUE TOXICITY OF OLANI IN A MINIPIG MODEL, AND STUDY 2 WILL GENERATE PILOT PHARMACOKINETIC (PK) DATA OF OLANI IN HEALTHY SUBJECTS IN ORDER TO DETERMINE POWER AND FINALIZE SAMPLE SIZE FOR A SUBSEQUENT BIOEQUIVALENCE (BE) STUDY AND TO SUPPORT FEASIBILITY AND TOLERABILITY. IF THERE ARE NO SAFETY CONCERNS AND NALTREXONE BLOOD LEVELS ARE ADEQUATE IN THE UG3 PHASE, THEN IN THE UH3 PHASE (STUDY 3) WILL BE FINALIZED IN CONSULTATION WITH NIDA AND FDA. STUDY 3 WILL COMPARE 6-MONTH PK OF OLANI VERSUS XR-NTX AS THE REFERENCE DRUG TO ESTABLISH BIOEQUIVALENCE (BE) IN TERMS OF NALTREXONE BLOOD LEVELS, SAFETY AND COMPARATIVE EFFECTIVENESS IN PATIENTS WITH OUD. PATIENTS WILL BE RANDOMIZED TO RECEIVE EITHER A SINGLE SUBCUTANEOUS IMPLANTATION OF 3.6G DOSE OF OLANI OR REPEAT DOSES OF VIVITROL 380 MG IM Q4 WEEKS FOR 24 WEEKS. PARTICIPANTS RANDOMIZED TO OLANI WILL BE OFFERED AN ADDITIONAL IMPLANT AT MONTH 6. WE HYPOTHESIZE THAT OLANI WILL HAVE A SYSTEMIC EXPOSURE (CMAX,CMIN,AUC0-180) AND MEC OF NALTREXONE BLOOD LEVELS COMPARABLE TO XR-NTX. IF OLANI IS SHOWN TO PROVIDE A SAFE, FEASIBLE AND EFFECTIVE METHOD OF DELIVERY OF NALTREXONE AT THERAPEUTIC LEVELS FOR AT LEAST 6 MONTHS, IT WOULD REPRESENT A MAJOR ADVANCE IN THE FIELD OF OUD TREATMENT, PROVIDING EFFECTIVE LONG TERM RELAPSE-PREVENTION TREATMENT TO INDIVIDUALS WITH OUD.

STRENGTHEN & IMPROVE THE NATION'S PUB HLT CAPACITY THROUGH NAT'L, NON-PROFIT, PR

BIOPOPLAR: A TUNABLE CHASSIS FOR DIVERSIFIED BIOPRODUCT PRODUCTION

GAINING EARLY AWARENESS AND READINESS FOR UNDERGRADUATE PROGRAMS (GEAR UP PARTNERSHIP)

MARSOC INJURY PREVENTION AND HUMAN PERFORMANCE RESEARCH

HEALTH PROFESSIONS OPPORTUNITY GRANTS- HOSOTOS COMMUNITY COLLEGE'S ALLIED HEALTH CAREER PIPELINE PROGRAM TO SERVE TANF RECIPIENTS AND LOW-INCOME INDI

2018-2022 OMNIBUS

RESEARCH IN THEORETICAL NUCLEAR PHYSICS

MISSOURI ENTERPRISE - MANUFACTURING EXTENSION PARTNERSHIP PROGRAM

SHIP COVID TESTING AND MITIGATION

HYPERGEN: GENETICS OF LEFT VENTRICULAR HYPERTROPHY

CHANGE THE COGNIZANT TECHNICAL OFFICER (CTO) IN THE AGREEMENT.

RESEARCH CENTER FOR STUDY OF GENE STRUCTURE AND FUNCTION

YOUTH WORK: ZIMBABWE PROGRAM

GEAR-UP

GEAR-UP

NYCENTER FOR MINORITY HEALTH, EQUITY AND SOCIAL JUSTICE - OVERALL-ABSTRACT THE OVERALL GOAL OF THE NEW RCMI AT THE CITY COLLEGE OF NEW YORK (CCNY) IS TO CREATE AN INTEGRATED MULTI-TIERED CENTER, THE NYCENTER FOR MINORITY HEALTH, EQUITY, AND SOCIAL JUSTICE (NYC-MHESJ). THIS PROPOSAL IS FOUNDED ON THE HISTORIC COMMITMENT OF CUNY MED AND CCNY TO THE HARLEM COMMUNITY. LOCATED IN HARLEM AND LED BY THE CUNY MED, THE NEW RCMI COLLABORATES WITH CCNY’S DIVISION OF SCIENCE, THE COLIN POWELL SCHOOL FOR CIVIC & GLOBAL LEADERSHIP, AND THE GROVE SCHOOL OF ENGINEERING. IT SPANS BASIC BIOMEDICAL, BEHAVIORAL, SOCIAL SCIENCE, AND CLINICAL RESEARCH. IT FURTHER DEVELOPS AND STRENGTHENS RESEARCH INFRASTRUCTURE, IMPROVES THE QUALITY OF SCIENCE, AND ENHANCES THE PREPARATION AND CAPACITY OF EARLY-STAGE INVESTIGATORS (ESI) TO CONDUCT STATE-OF-THE-ART HEALTH DISPARITIES RESEARCH WHILE, CREATING STRATEGIC COMMUNICATIONS, AND IMPLEMENTING A DISSEMINATION PLAN FOCUSED ON UNDERSERVED NYC COMMUNITIES WHERE DEEP DISPARITIES EXIST AND PERSIST. THE SPECIFIC AIMS AND KEY ACTIVITIES FOR THE OVERALL CORE ARE TO: AIM-1 SUPPORT THREE OUTSTANDING R01-LEVEL RESEARCH PROJECTS CENTERED ON HEALTH DISPARITIES: • A BASIC SCIENCE PROPOSAL FOCUSED ON END-STAGE KIDNEY DISEASE, WHICH PREDOMINANTLY AFFECTS MINORITY POPULATIONS SUCH AS AFRICAN-AMERICANS AND LATINO(S); • A BEHAVIORAL SCIENCE PROJECT FOCUSED ON MENTAL HEALTH AND STIGMA IN ADOLESCENTS • A CLINICAL PROJECT FOCUSED ON UNDERSTANDING CLINICAL TRIAL PARTICIPATION AND RECRUITMENT PARAMETERS OF HISPANICS WITH PARKINSON’S DISEASE AIM-2 CREATE A RESEARCH CAPACITY CORE (RCC) TO STRENGTHEN CUNY MED AND CCNY’S RESEARCH CAPACITY BY EXPANDING ACCESS AND TRAINING IN MOLECULAR BIOLOGY/GENOMICS TECHNOLOGIES, ACCESS TO A BIOSTATISTICS, EPIDEMIOLOGY, AND RESEARCH DESIGN CORE, ARTIFICIAL INTELLIGENCE (AI), AND DATA AND COMPUTATIONAL SCIENCE TO STUDY HEALTH DISPARITIES. AIM-3 CREATE AND ADMINISTER AN INVESTIGATOR DEVELOPMENT CORE (IDC) LED BY EXPERIENCED MENTORS TO DEVELOP FACULTY, AWARD PILOT PROJECTS, AND ENHANCE TRAINING ACTIVITIES FOR UNDERREPRESENTED ESI AND FACULTY WITHIN AN EFFECTIVE INTEGRATED MENTORING PROGRAM. AIM-4 CREATE A COMMUNITY ENGAGEMENT CORE (CEC) FOCUSED ON MINORITY HEALTH AND HEALTH DISPARITES (HD) IN UNDERSERVED NYC COMMUNITIES. AIM-5 CREATE A RECRUITMENT CORE (RC) TO INCREASE THE CRITICAL MASS OF SENIOR-LEVEL HEALTH DISPARITIES INVESTIGATORS. AIM-6 DEVELOP AN ADMINISTRATIVE CORE (AC) THAT INTEGRATES AND ALIGNS INSTITUTIONAL AND CENTER GOALS AND EVALUATES AND SUPPORTS THE CENTER’S SCIENTIFIC ADVANCEMENT.

IRACDA - THE NEW YORK CONSORTIUM FOR THE ADVANCEMENT OF POSTDOCTORAL SCHOLARS (NY

EXPANSION OF THE UNIVERSITY OF KENTUCKY CENTER FOR APPLIED ENERGY RESEARCH LABORATORY FACILITIES.

DEVELOPMENT OF A LONG-ACTING ENZYME THERAPY FOR TREATMENT OF COCAINE ABUSE