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SBIR PHASE II: DEVELOPMENT OF A STOICHIOMETRIC, DIRECT-INJECTED, SOOT-FREE ENGINE FOR HEAVY-DUTY APPLICATIONS

COMBUSTION GEOMETRY OPTIMIZATION TO INCREASE ALCOHOL-FUELED MCCI EFFICIENCY

DESIGNING DRUGS THAT SUPRESS CHRONIC BRAIN INFLAMMATION

INHIBITION OF COMPLEMENT PATHWAYS WITH VCP AS A TREATMENT FOR ALZHEIMER'S DISEASE - PROJECT SUMMARY/ABSTRACT VACCINIA VIRUS COMPLEMENT CONTROL PROTEIN (VCP) HAS BEEN SHOWN TO HAVE STRUCTURAL AND FUNCTIONAL SIMILARITY TO HUMAN COMPLEMENT CONTROL PROTEINS. VCP MODULATES THE HUMAN AND RODENT COMPLEMENT SYSTEM. DURING THE PAST TWO DECADES, WE HAVE STUDIED VCP EXTENSIVELY IN A NUMBER OF PRECLINICAL INFLAMMATORY DISEASE MODELS INCLUDING ALZHEIMER’S DISEASE (AD) AND SPINAL CORD INJURY (SCI) AND DEMONSTRATED THAT CONTROLLING COMPLEMENT MEDIATED INFLAMMATION BY VCP HAS SIGNIFICANTLY IMPROVED OUTCOMES, LEADING TO OUR HYPOTHESIS THAT VCP CAN BE POTENTIALLY USED FOR THERAPEUTIC TREATMENTS OF THESE DISEASES. AD IS ONE OF THE MOST DEVASTATING DISEASES AMONGST THE AGING POPULATION IN THE WORLD AND THE 6TH LEADING CAUSE OF DEATH IN THE US. IT IS WELL KNOWN THAT AMYLOID PROTEINS AND PLAQUES ARE ASSOCIATED WITH ACTIVATION OF SEVERAL PROINFLAMMATORY MEDIATORS, ESPECIALLY COMPLEMENT COMPONENTS. INTERESTINGLY, APOE GENOTYPES THAT SIGNIFICANTLY FACILITATE A- DEPOSIT, ARE STRONGLY INVOLVED IN REGULATION OF CLASSICAL COMPLEMENT CASCADE. THESE PRO-INFLAMMATORY MEDIATORS CAN CAUSE DAMAGE ON THEIR OWN AS WELL AS WORKING IN SYNERGY WITH EACH OTHER, ULTIMATELY LEADING TO NEURODEGENERATION. OVER TIME, THE DAMAGING ROLE OF COMPLEMENT COMPONENTS OVERPOWERS THEIR BENEFICIAL EFFECTS AS THE DISEASE PROGRESSES. AS A RESULT, COMPLEMENT PATHWAYS HAVE BECOME POTENTIAL TARGETS FOR DEVELOPING TREATMENTS OF DISEASES SUCH AS AD. TO PROVIDE A PROOF OF CONCEPT, WE INVESTIGATED THE ROLE OF COMPLEMENT PATHWAYS REGULATED BY VCP IN AD MICE MODEL. IN THIS MODEL, VCP WAS SHOWN TO BE EFFECTIVE IN PREVENTING MEMORY LOSS. TO FURTHER DEVELOP VCP AS A POTENTIAL TREATMENT FOR AD, IN THIS SBIR PHASE I STUDY, WE WILL AIM AT CHARACTERIZING HIGH QUALIFY HUMANIZED RECOMBINANT VCP (HRVCP) AND AT THE ASSESSMENT OF CANDIDATE HRVCP IN ANIMAL MODELS IN A MORE CLINICAL RELEVANT MANNER BY AN INDEPENDENT CRO COMPANY WITH TWO SPECIFIC AIMS: 1) TO SUBJECT HRVCP TO A FULL BATTERY OF IN-HOUSE ANALYTICAL CHARACTERIZATION AND STABILITY PROFILING; ; SPECIFIC AIM 2: TO VALIDATE OUR PREVIOUS FINDINGS BY TESTING EFFICACY OF HRVCP IN APP/PS1 AD MODELS WITH COLLABORATION OF AN INDEPENDENT CRO LABORATORY. OUR MILESTONE GOALS INCLUDE DEVELOPMENT OF ACTIVE AND STABLE HRVCP PRE-FORMULATION IN SALINE, PRODUCTION OF MORE HRVCP IF RESOURCES ALLOW, AND VALIDATION OF EFFICACY DATA IN AD MODELS FROM A LABORATORY OTHER THAN OUR OWN. IF WE ARE SUCCESSFUL, PK/SAFETY ASSESSMENTS AND OTHER PRECLINICAL STUDIES OF PURIFIED HRVCP PROTEIN WILL BE THE GOAL OF PHASE II STUDIES, ALONG WITH EVEN MORE RIGOROUS SAFETY STUDIES INCLUDING IN VITRO CARDIOTOXICITY, HEPATOTOXICITY AND BONE MARROW TOXICITY STUDIES IN STEM CELLS DERIVED TISSUE CELLS. WE EXPECT THAT THE SBIR PHASE1 STUDIES WILL LEAD TO DEVELOPMENT OF HRVCP FOR A COMMERCIAL SCALE THERAPEUTIC APPROACH TO TARGET THE PROGRESSION OF NEUROINFLAMMATION AND NEURODEGENERATION ANTICIPATED IN AD PATIENTS.

DEVELOPING A PRENATAL BIOLOGIC THERAPY TO MITIGATE ASD RISK FROM MATERNAL AUTOANTIBODIES TO CASPR2

SBIR PHASE I: DEVELOPMENT OF A STOICHIOMETRIC, DIRECT-INJECTED, SOOT-FREE ENGINE FOR HEAVY-DUTY APPLICATIONS

PURPOSE: TO SUPPORT PERSONNEL AND FACILITIES EXPENSES IN RESPONSE TO AND RECOVERY FROM THE COVID-19 PANDEMIC.

ETHANOL DUAL-FUEL ENGINE RETROFITS TO DISPLACE DIESEL USAGE IN FARM EQUIPMENT

AUTISM SPECTRUM DISORDER DIAGNOSTIC/THERAPEUTIC AGENT

A DIAGNOSTIC FOR MATERNAL AUTOAB TO CASPR2 TO PREDICT INCREASED RISK OF AUTISM SPECTRUM DISORDER IN CHILDREN

PURPOSE: TO SUPPORT ARTIST FEES FOR THE FESTIVAL FLAMENCO ALBURQUERQUE.

PURPOSE: TO SUPPORT ARTIST FEES FOR THE 35TH ANNUAL FESTIVAL FLAMENCO ALBURQUERQUE.

PURPOSE: TO SUPPORT ARTIST FEES FOR THE FESTIVAL FLAMENCO ALBUQUERQUE.

PURPOSE: TO SUPPORT ARTIST TRAVEL COSTS FOR THE FESTIVAL FLAMENCO ALBUQUERQUE.

TO SUPPORT PERSONNEL AND FACILITIES COSTS IN RESPONSE TO THE COVID-19 PANDEMIC.

PURPOSE: TO SUPPORT TOURING PERFORMANCES OF SEARCHING FOR GOYA.

TO SUPPORT ARTIST FEES FOR THE 34TH ANNUAL FESTIVAL FLAMENCO ALBURQUERQUE.

TO SUPPORT ARTIST FEES FOR THE ANNUAL FESTIVAL FLAMENCO ALBURQUERQUE.

PURPOSE: TO SUPPORT PERFORMANCES ON TOUR OF AN ORIGINAL FLAMENCO PRODUCTION BASED ON FRANCISCO GOYAS ART WITH ACCOMPANYING ENGAGEMENT ACTIVTIES.

PURPOSE: TO SUPPORT THE DEVELOPMENT AND PRODUCTION OF A DANCE WORK BY CHOREOGRAPHER JESÚS MUÑOZ.

PURPOSE: TO SUPPORT JESÚS MUÑOZ FLAMENCOS FIESTA FLAMENCA A FREE DANCE FESTIVAL OF PERFORMANCES AND EDUCATIONAL PROGRAMMING.

TO SUPPORT THE FESTIVAL FLAMENCO INTERNACIONAL DE ALBUQUERQUE.

TO SUPPORT THE CREATION AND PRESENTATION OF "DESEO" (DESIRE), A NEW FLAMENCO WORK BY ARTISTIC DIRECTOR MARTIN SANTANGELO.

TO SUPPORT THE ANNUAL FESTIVAL FLAMENCO INTERNACIONAL DE ALBUQUERQUE.

TO SUPPORT THE PRESENTATION AND TOUR OF A FLAMENCO DANCE BASED ON ANTON CHEKOV'S STORY "THE HUNTSMAN."

PURPOSE: TO SUPPORT THE CREATION AND PRESENTATION OF A LIVE FLAMENCO PRODUCTION BASED ON SELECTED WORKS OF ARTIST FRANCISCO GOYA.

TO SUPPORT THE ANNUAL FESTIVAL FLAMENCO INTERNACIONAL DE ALBURQUERQUE.

TO SUPPORT RESIDENCY ACTIVITIES FOR FLAMENCO ARTISTS TRAVELING FROM SPAIN TO NEW MEXICO.

COMMUNITY FACILITIES - ECONOMIC IMPACT INITIATIVE GRANTS

PURPOSE: TO SUPPORT THE CREATION AND PRESENTATION OF A CONTEMPORARY FLAMENCO DANCE WORK FEATURING PERFORMERS ALICE BLUMENFELD AND FELISE BAGLEY.

PURPOSE: TO SUPPORT A FLAMENCO RESIDENCY PROGRAM AND PUBLIC PERFORMANCES.

PURPOSE: TO SUPPORT THE CREATION AND PRESENTATION OF A THEATER AND FLAMENCO DANCE PROJECT WITH ASSOCIATED PUBLIC PROGRAMMING.

TO SUPPORT THE CREATION AND PRESENTATION OF AN ORIGINAL FLAMENCO INTERPRETATION OF SOPHOCLES PLAY WOMEN OF TRACHIS.

TO SUPPORT THE RESEARCH DEVELOPMENT AND PERFORMANCE OF A NEW DANCE WORK BASED ON THE GREEK MYTH OF DEMETER AND PERSEPHONE.

TO SUPPORT A RESIDENCY WITH FLAMENCO ARTIST BELÉN MAYA AS PART OF THE MAJAS APPRENTICE PROGRAM.

TO SUPPORT THE CREATION AND PRESENTATION OF A NEW WORK "LA RONDE.

TO SUPPORT THE MAJAS APPRENTICE PROGRAM.

TO SUPPORT THE CREATION AND PRESENTATION OF A NEW WORK BASED ON A RUMI POEM CALLED "THE CHRISTIAN, THE MUSLIM, AND THE JEW," BY ARTISTIC DIRECTOR MAR

TO SUPPORT THE CONTINUED DEVELOPMENT AND PRESENTATION OF "ANTIGONA," A FLAMENCO INTERPRETATION OF THE TEXT AND THEMES IN SOPHOCLES' PLAY, "ANTIGONE,"

TO SUPPORT A UNITED STATES TOUR OF FLAMENCO DANCE PROGRAMS.

TO SUPPORT A TOUR OF FLAMENCO DANCE PERFORMANCES.

TO SUPPORT A UNITED STATES TOUR OF FLAMENCO DANCE PROGRAMS.

TO SUPPORT THE TOUR OF A SERIES OF FLAMENCO PERFORMANCES.

TO SUPPORT A TOUR OF FLAMENCO DANCE ACROSS THE UNITED STATES.

SEC 9007 REAP-RENEW ENERGY EFFICIENCY IMPROVE GRANTS $20 000 OR LESS (MAN)

COMBUSTION OF LIQUID FUELS IN THE AIR CORE OF ROTATING WATER FOR APPLICATION IN A DOWNHOLE STEAM GENERATOR