Southern Illinois University

HEAD START: FULL YEAR PART DAYHANDICAPPED TRAINING AND TECHNICAL ASSISTANCE

HEAD START/EARLY HEAD START

HEAD START AND EARLY HEAD START

RECIPIENT'S FUNDING CERTIFICATION AND AGREEMENT - EMERGENCY FINANCIAL AID GRANTS TO STUDENTS UNDER THE CORONAVIRUS AID, RELIEF, AND ECONOMIC SECURITY (CARES) ACT

HEALTH CENTER CLUSTER

HEAD START

SIU CARES INSTITUTIONAL PORTION

HEAD START: FULL YEAR PART DAY HANDICAPPED TRAINING AND TECHNICAL ASSISTANCE

RECIPIENT'S FUNDING CERTIFICATION AND AGREEMENT - EMERGENCY FINANCIAL AID GRANTS TO STUDENTS UNDER THE CORONAVIRUS AID, RELIEF, AND ECONOMIC SECURITY (CARES) ACT

SIUC CARES

HEAD START

HEALTH CENTER CLUSTER

HEAD START AND EARLY HEAD START

TRADE ADJUSTMENT ASSISTANCE COMMUNITY COLLEGE AND CAREER TRAINING

THE SOMATOTROPIC AXIS AND HEALTH AGING: A SEARCH FOR MECHANISMS

AMERICAN RESCUE PLAN ACT FUNDING FOR HEALTH CENTERS

CODING IN AUDITORY NEURONS: EFFECTS OF AMINO ACIDS

REHABILITATION CONTINUING EDUCATION PROGRAM

CELLULAR SENESCENCE, INFLAMMATION AND NEUROTRANSMISSION IN ALZHEIMER'S DISEASE

NURSE EDUCATION, PRACTICE, QUALITY AND RETENTION

INTERACTION OF CALORIC RESTRICTION WITH LONGEVITY GENES

LONG RANGE LOW FREQUENCY HIGH AMPLITUDE ACOUSTICAL PROPORAGATION STUDY

NURSE EDUCATION PRACTICE QUALITY AND RETENTION: CLINICAL FACULTY AND PRECEPTOR ACADEMY - THE PRIMARY GOAL OF THIS PROJECT IS TO RECRUIT AND TRAIN CLINICAL FACULTY AND PRECEPTORS IN LOCAL AND REGIONAL COMMUNITY HEALTHCARE AND ACADEMIC ORGANIZATIONS WHICH SERVE RURAL AND MEDICALLY UNDERSERVED POPULATIONS. THIS ADDRESSES THE FUNDING PREFERENCE OF THIS GRANT, UNDER QUALIFICATION 2, FOCUSED ON SUBSTANTIALLY BENEFITING UNDERSERVED POPULATIONS. THE POPULATION OF CLINICAL FACULTY AND PRECEPTORS THAT WILL BE RECRUITED AND TRAINED THROUGH THIS PROPOSED PROJECT INCLUDE FEDERALLY DESIGNATED MEDICALLY UNDERSERVED AREAS (MUA) AND MEDICALLY UNDERSERVED POPULATIONS (MUP) THROUGHOUT ILLINOIS AND THE HHS REGION 5 STATES, AS NOTED IN OUR FUNDING PREFERENCE REQUEST. THE OBJECTIVES OF THIS PROJECT ARE: 1) ESTABLISH A SUSTAINABLE CLINICAL FACULTY AND PRECEPTOR TRAINING PROGRAM TO EXPAND THE NURSING WORKFORCE SERVING RURAL AND UNDERSERVED POPULATIONS IN ILLINOIS AND THE HHS REGION 5 STATES; 2) FOSTER A LEARNING EXPERIENCE THAT PROMOTES KNOWLEDGE BUILDING AND ENHANCEMENT OF CLINICAL FACULTY AND PRECEPTOR ABILITIES, RESILIENCY, AND EMOTIONAL INTELLIGENCE; 3) MAINTAIN, CREATE, AND EXPAND COLLABORATIVE PARTNERSHIPS BETWEEN ACADEMIA AND PRACTICE TO PROMOTE CLINICAL FACULTY AND PRECEPTOR EDUCATION TO INCREASE THE NUMBER OF CLINICAL FACULTY AND PRECEPTORS TRAINING NURSES IN RURAL AND UNDERSERVED COMMUNITIES; 4) INCREASE THE RECRUITMENT OF CLINICAL FACULTY AND PRECEPTORS WORKING IN RURAL AND UNDERSERVED COMMUNITIES WITHIN HHS REGION 5. GRADUATE NURSING STUDENTS ENROLLED IN NURSE EDUCATOR PROGRAMS, NURSE PRACTITIONER PROGRAMS, AND NURSE ANESTHESIA PROGRAMS, CLINICAL FACULTY, REGISTERED NURSES AND ADVANCED PRACTICE NURSES WORKING IN INPATIENT AND OUTPATIENT SETTINGS, AND NEW AND EXISTING PRECEPTORS IN HHS REGION 5 STATES WILL BE THE TARGETED POPULATION FOR THIS PROJECT. STUDENTS ENROLLED IN GRADUATE NURSING PROGRAMS ARE OFTEN EXPERIENCED REGISTERED NURSES WHO ARE ALREADY OR WILL SOON TAKE ON PRECEPTOR ROLES AND CLINICAL FACULTY ROLES IN THE NURSING WORKFORCE. CUR RENT PRECEPTORS IN THE COMMUNITY AND CLINICAL FACULTY ARE OFTEN ENGAGED IN THE ROLE OF PRECEPTOR WITHOUT FORMAL TRAINING AND LACK SUPPORT. THE PROJECT SEEKS TO REACH POPULATIONS THROUGH THE DEVELOPMENT OF EASILY ACCESSIBLE SELF-PACED INTERNET-BASED TRAINING MODULES, AN ANNUAL CLINICAL FACULTY AND PRECEPTOR CONFERENCE, AND INCORPORATION OF EMOTIONAL INTELLIGENCE AND RESILIENCY COACHING. THESE MODULES WILL COVER TOPICS IMPORTANT FOR CLINICAL FACULTY AND PRECEPTORS INCLUDING METHODS OF GIVING CONSTRUCTIVE FEEDBACK, UNCONSCIOUS BIAS, CHALLENGING STUDENT SITUATIONS, BUILDING STUDENT INDEPENDENCE AND CONFIDENCE, EMOTIONAL INTELLIGENCE, RESILIENCY, AND DEVELOPING CLINICAL STUDENT LEARNING AND EVALUATION PLANS. THE CLINICAL FACULTY AND PRECEPTOR ANNUAL CONFERENCE WILL BE HOSTED AT THE SIUE CAMPUS USING A HYBRID FORMAT TO FACILITATE ATTENDANCE FOR ALL PARTICIPANTS WITHIN HHS REGION 5. EACH YEAR THE PROGRAM’S GOAL IS TO TRAIN 60 STUDENTS IN GRADUATE NURSE EDUCATOR, NURSE ANESTHESIA, OR NURSE PRACTITIONER PROGRAMS, 100 HEALTHCARE PRECEPTORS AND 40 CLINICAL FACULTY FOR EACH YEAR OF THE PROJECT PROGRAM FUNDING. AFTER COMPLETION OF THE MODULES AND ATTENDANCE AT THE ANNUAL CONFERENCE, PARTICIPANTS WILL BE PROVIDED WITH A STIPEND AND CONTINUING EDUCATION CERTIFICATE. SIUE IS IN HHS FUNDING REGION 5. THE TOTAL REQUESTED FOR THIS GRANT IS $3,813,888.63 OVER A PERIOD OF 4 YEARS.

DELTA STATE RURAL DEVELOPMENT NETWORK GRANT PROGRAM (DELTA)

A COMMUNITY OF PROBLEM SOLVERS: TEACHERS LEADING PROBLEM-BASED LEARNING IN SOUTHERN ILLINOIS

IGERT: MULTIDISCIPLINARY, TEAM-BASED TRAINING IN WATERSHED SCIENCE AND POLICY

GLUTAMATE NEUROTRANSMISSION IN ALZHEIMER'S DISEASE PROGRESSION

LEAD OPTIMIZATION OF SOMATOSTATIN-BASED THERAPEUTIC FOR ALZHEIMER'S DISEASE

TRIO UPWARD BOUND EC SERVING 150 STUDENTS (EAST ST. LOUIS HIGH SCHOOL / SOUTHERN ILLINOIS UNIVERSITY EDWARDSVILLE CHARTER SCHOOL)

OPTIMIZING D-METHIONINE (D-MET) PRE-LOADING AND RESCUE DOSING THROUGH FUNCTIONAL AND BIOMARKER MEASURES

UNDERSTANDING COMPOUND PHASE TRASITIONS IN NEW HEUSLER ALLOY COLOSSAL MAGNETOCALORIC MATERIALS

ENDOGENOUS MODULATION OF COCHLEAR INJURY

ADVANCED NURSING EDUCATION WORKFORCE

UPWARD BOUND

SOUTHERN ILLINOIS BRIDGES TO THE BACCALAUREATE PROGRAM

RURAL COMMUNITIES OPIOID RESPONSE PROGRAM - MEDICATION ASSISTED TREATMENT ACCESS - PROJECT TITLE: SOUTHERN ILLINOIS UNIVERSITY (SIU) COMMUNITY HEALTH PROGRAM MEDICATION ASSISTED TREATMENT (MAT) EXPANSION PROJECT REQUESTED AWARD AMOUNT: $2,669,913 APPLICANT ORGANIZATION NAME: BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY FACILITY TYPE: PUBLIC UNIVERSITY AND FEDERALLY QUALIFIED HEALTH CENTER ADDRESS: 520 N 4TH STREET, SPRINGFIELD IL 62702-5238 WEBSITE: HTTPS://WWW.SIUMED.EDU/CENTERS-FAMILY-MEDICINE PROJECT DIRECTOR AND TITLE: CAMILLE DUNKLEY, MD, ASSISTANT PROFESSOR OF FAMILY AND COMMUNITY MEDICINE, DIRECTOR OF MEDICATION ASSISTED RECOVERY PROJECT DIRECTOR CONTACT: PHONE: 217-757-8137 FAX: 217-545-5806 EMAIL: CDUNKLEY46@SIUMED.EDU LEARNED OF FUNDING OPPORTUNITY: HRSA NEWS RELEASE & GRANTS.GOV BRIEF DESCRIPTION OF TARGET SERVICE AREA: TWO HRSA-DESIGNATED RURAL COUNTIES (CHRISTIAN AND MORGAN) IN ILLINOIS. TARGET POPULATION: RESIDENTS OF CHRISTIAN COUNTY: 95% WHITE (NON-HISPANIC), 1.3% AFRICAN AMERICAN (NON-HISPANIC), 1.6% HISPANIC OR LATINO, 0.3% AS AMERICAN INDIAN/ALASKA NATIVE (NON-HISPANIC). RESIDENTS OF MORGAN COUNTY: 88% WHITE (NON-HISPANIC), 6.8% AFRICAN AMERICAN (NON-HISPANIC), 2.5% HISPANIC OR LATINO, 0.2% AS AMERICAN INDIAN/ALASKA NATIVE (NON-HISPANIC). THE PRIMARY AIM OF THIS PROJECT IS TO ESTABLISH TWO OUTPATIENT MEDICATION-ASSISTED TREATMENT (MAT) CLINICS IN TAYLORVILLE AND JACKSONVILLE, IL, WHICH ARE IN CHRISTIAN AND MORGAN COUNTY, RESPECTIVELY. THESE CLINICS WILL BE ESTABLISHED WITHIN THE EXISTING SIU CENTER FOR FAMILY MEDICINE PRIMARY CARE CLINICS. THEY WILL PROVIDE LEVEL 1 TREATMENT SERVICES AS DESIGNATED BY THE ILLINOIS SUBSTANCE USE PREVENTION AND RECOVERY (SUPR) LICENSE. THESE CLINICS WILL SERVE PATIENTS WITH OPIOID USE DISORDER, ALCOHOL USE DISORDER, AND CO-OCCURRING ADDICTION AND MENTAL HEALTH DISORDERS. THE MAT OPTIONS WILL INCLUDE SUBLINGUAL BUPRENORPHINE, BUPRENORPHINE EXTENDED-RELEASE INJECTABLE, AND NALTREXONE-EXTENDED RELEASE INJECTABLE. BEHAVIORAL SERVICES WILL BE INTEGRATED INTO THE C LINIC AND OFFERED ON-SITE. ADDITIONAL ADJUNCTIVE SERVICES WILL INCLUDE PEER SUPPORT, COMMUNITY HEALTH WORKERS, AND CASE MANAGEMENT.

ENHANCING PHYSICAL ACTIVITY AFTER BREAST CANCER DIAGNOSIS: RANDOMIZED TRIAL

DELTA STATE RURAL DEVELOPMENT NETWORK GRANT PROGRAM (DELTA)

BEHAVIORAL HEALTH WORKFORCE EDUCATION AND TRAINING PROGRAM

ORAL EPIGALLOCATECHIN GALLATE (EGCG) FOR TREATMENT OF CISPLATIN OTOTOXICITY

EEG & BEHAVIORAL PREDICTORS OF CHANGES IN SMOKING TRAJECTORIES IN YOUNG LIGHT SMO

BEHAVIORAL HEALTH WORKFORCE EDUCATION AND TRAINING PROGRAM

RIVER REGION MASTER TEACHING FELLOWSHIPS IN ENVIRONMENTAL SUSTAINABILITY

SANGAMON COUNTY ILLINOIS ASSISTED OUTPATIENT TREATMENT

DELTA STATE RURAL DEVELOPMENT NETWORK GRANT PROGRAM (DELTA)

PROJECT UPWARD BOUND, SOUTHERN ILLINOIS UNIVERSITY CARBONDALE

UPWARD BOUND PROGRAM AT EAST ST. LOUIS AND CAHOKIA HIGH SCHOOLS (EC)

NURSE, EDUCATION, PRACTICE, QUALITY AND RETENTION - REGISTERED NURSES IN PRIMARY CARE

FEATURES OF CHRONIC TINNITUS IN AN ANIMAL MODEL AS INDICATED BY MEMRI AND MRS

UPWARD BOUND PROGRAM

BEHAVIORAL HEALTH WORKFORCE EDUCATION AND TRAINING PROGRAM- AMERICAN RESCUE PLAN

UPWARD BOUND PROGRAM

NURSING WORKFORCE DIVERSITY

PROJECT UPWARD BOUND, SOUTHERN ILLINOIS UNIVERSITY CARBONDALE

AFFORDABLE CARE ACT: PRIMARY CARE RESIDENCY EXPANSION

HEARTLAND PARTNERSHIPS: INQUIRY-BASED ECOLOGICAL AND ENVIRONMENTAL EDUCATION AT SIUC

CEREBELLAR GRANULE CELL DYSFUNCTION IN SHANK3 MUTANT MICE - PROJECT SUMMARY/ABSTRACT AUTISM SPECTRUM DISORDER (ASD) IS A COMPLEX NEUROLOGICAL DISORDER ASSOCIATED WITH A BROAD COLLECTION OF GENETIC MUTATIONS AND ENVIRONMENTAL FACTORS. WHILE IDENTIFYING THE NEURAL UNDERPINNINGS OF ASD HAS BEEN A MAJOR FOCUS IN THE FIELD OF GENETICS AND NEUROSCIENCE, IT IS NOT CLEAR WHICH BRAIN REGION (S) AND CELL TYPES MAY BE FUNCTIONING ABNORMALLY TO GIVE RISE TO ASD. THE CEREBELLUM, A BRAIN REGION TYPICALLY CONSIDERED TO BE INVOLVED IN MOTOR COORDINATION AND CONTROL, HAS RECEIVED CONSIDERABLE ATTENTION FOR ITS POTENTIAL ROLE IN ASD, WITH A GROWING BODY OF CLINICAL EVIDENCE CORRELATING ASD DIAGNOSES WITH ABNORMALITIES IN CEREBELLAR ANATOMY, FUNCTION, AND MOTOR OR VESTIBULAR BEHAVIORS/FUNCTIONS. IN PARALLEL, CEREBELLAR INVOLVEMENT IN CIRCUITS OUTSIDE OF THE MOTOR SYSTEM PROVIDES A SUBSTRATE FOR THE CEREBELLUM TO INFLUENCE NON-MOTOR BEHAVIORS AND PROCESSES, SETTING THE STAGE FOR THE IMPORTANCE OF APPROPRIATE CEREBELLAR FUNCTION IN A HOST OF NEURAL PROCESSES. WITHIN THE CEREBELLUM, THE INITIAL INTEGRATION OF ALL INCOMING SENSORIMOTOR INFORMATION ENTERING THE CEREBELLAR CORTEX IS CARRIED OUT BY THE MORPHOLOGICALLY SIMPLE AND EXTREMELY DENSE POPULATION OF GRANULE CELLS. THESE GRANULE CELLS ALSO EXPRESS MANY HIGH RISK ASD-LINKED GENES, ESPECIALLY THOSE INVOLVED IN SYNAPTIC TRANSMISSION AND DEVELOPMENT. HOWEVER, LITTLE IS KNOWN ABOUT THE ROLE AND IMPORTANCE OF MANY ASD-LINKED GENES IN THE CEREBELLUM, ESPECIALLY IN GRANULE CELLS. IT IS ALSO NOT CLEAR WHAT ASPECTS OF CEREBELLAR GRANULE CELL FUNCTION AND CONNECTIVITY MAY BE IMPORTANT FOR SHAPING CERTAIN NON-MOTOR (AND MOTOR) BEHAVIORS. TO ADDRESS THIS KNOWLEDGE GAP, IN AIMS 1 AND 2 WE PROPOSE TO IDENTIFY THE DEGREE TO WHICH AN ASD-LINKED GENE DETERMINES PROPERTIES OF CEREBELLAR GRANULE CELL SYNAPTIC INTERACTIONS AND CORTICAL CIRCUITRY DYNAMICS OVER TIME. IN AIM 3, WE WILL IDENTIFY HOW A PARTICULAR ASD-LINKED GENE IN CEREBELLAR GRANULE CELLS INFLUENCE BEHAVIORAL PHENOTYPE ACROSS MOTOR AND NON-MOTOR DOMAINS. RESULTS FROM THE PROPOSED WORK WILL BE KEY IN IDENTIFYING A MECHANISTIC LINK BETWEEN A GENE/PROTEIN LINKED TO ASD AND SPECIFIC SYNAPTIC ABNORMALITIES IN THE CEREBELLUM.

MECHANISMS OF FATIGUE IN A CHRONIC VIRAL DISEASE

UPWARD BOUND

DEVELOPING D-METHIONINE AS AN AMINOGLYCOSIDE OTOPROTECTANT

THERAPEUTIC EFFICACY OF FLAXSEED IN THE TREATMENT OF OVARIAN CANCER

NICOTINIC RECEPTOR PATHOLOGY IN TINNITUS: AUDITORY CORTEX AND SELECTIVE DESENSITIZING NICOTINIC AGENTS

COLLABORATIVE RESEARCH: UPPER DELTA REGION BIODIVERSITY SCHOLARSHIP

CHROMATIN REMODELING AND TRANSCRIPTION REPRESSION

SIUC TRIO STUDENT SUPPORT SERVICES

NOVEL ROLE OF MYELOID-DERIVED LYMPHATIC PROGENITORS IN INDUCTION OF BREAST CANCER LYMPHATICS

NRT & BUPROPION MECHANISMS OF EFFICACY IN SMOKERS

ULTRAFAST DYNAMICS IN ENZYME CATALYSIS

MECHANISMS THAT REGULATE HAIR CELL SURVIVAL

UPWARD BOUND

TRIO UPWARD BOUND MLC SERVING 75 STUDENTS (MADISON HIGH SCHOOL, LOVE-JOY TECHNICAL HIGH SCHOOL, CAHOKIA HIGH SCHOOL)

AT THE CONFLUENCE: SUPPORTING CRITICAL TRANSITIONS FOR GRADUATE STUDENTS IN SUSTAINABLE WATERSHEDS RESEARCH

TRANSPLATIN: A NOVEL AGENT TO MITIGATE CISPLATIN TOXICITY

INVESTIGATION OF NOTCH SIGNALING DURING SPONTANEOUS REGENERATION OF COCHLEAR HAIR CELLS

DEVELOPMENT OF NEW THERAPIES THAT STIMULATE HAIR CELL REGENERATION

NF-KB MEDIATED INDUCTION OF VEGFR-3 AND NEW LYMPHATIC VESSELS IN BREAST CANCER

STUDENT SUPPORT SERVICES PROGRAM

AROUND THE NATION, NASA'S FACILITIES SERVE AS CENTERS FOR RESEARCH AND ENGAGEMENT WITH FORMAL AND INFORMAL LEARNERS. THIS LATTER ROLE MAKES NASAS CEN

CNH: CLIMATE CHANGE HYDROLOGY AND LANDSCAPES OF AMERICA'S HEARTLAND: A MULTI-SCALE NATURAL-HUMAN SYSTEM

PRIMARY CARE TRAINING AND ENHANCEMENT

STUDENT SUPPORT SERVICES PROGRAM

UPWARD BOUND MATH AT SCIENCE AT CAHOKIA AND MADISON HIGH SCHOOLS

A NOVEL APPROACH FOR CHRONIC PAIN TREATMENT USING RESINIFERATOXIN

VETERANS UPWARD BOUND PROGRAM AT SIUE, SERVING VETERANS IN THE ST. LOUIS METROPOLITAN AREA

CONVERGING EARTH SCIENCE AND SUSTAINABILITY EDUCATION AND EXPERIENCE TO PREPARE NEXT-GENERATION GEOSCIENTISTS -THIS PROJECT WILL CONTRIBUTE TO THE NATIONAL NEED FOR WELL-EDUCATED SCIENTISTS, MATHEMATICIANS, ENGINEERS, AND TECHNICIANS BY SUPPORTING THE RETENTION AND GRADUATION OF HIGH-ACHIEVING, LOW-INCOME STUDENTS WITH DEMONSTRATED FINANCIAL NEED AT SOUTHERN ILLINOIS UNIVERSITY CARBONDALE (SIUC). SIUC IS A RURAL UNIVERSITY AND THE MAJOR RESEARCH INSTITUTION IN SOUTHERN ILLINOIS, ONE OF AMERICA?S MOST ECONOMICALLY DISTRESSED REGIONS. OVER ITS FIVE-YEAR DURATION, THIS PROJECT WILL FUND SCHOLARSHIPS TO 40 UNIQUE FULL-TIME TRANSFER STUDENTS WHO ARE PURSUING BACHELOR?S DEGREES IN GEOGRAPHY & ENVIRONMENTAL RESOURCES AND GEOLOGY. TRANSFER STUDENTS WILL RECEIVE TWO-YEAR SCHOLARSHIPS. THE PROPOSED PROJECT IS AN INTERDISCIPLINARY STEM PROGRAM, EARTH-SUSTAINABILITY SCHOLARSHIP (ESS), FOR ACADEMICALLY TALENTED STUDENTS WHO DEMONSTRATE FINANCIAL NEED TO PURSUE UNDERGRADUATE ENVIRONMENTAL AND EARTH SCIENCE DEGREES. A SUSTAINABILITY-MINDED STEM WORKFORCE IS VITAL FOR THE NATION TO STRATEGICALLY DEVELOP NATURAL RESOURCES, EXPERIENCE ECONOMIC GROWTH, AND MAKE INFORMED DECISIONS IN A RAPIDLY CHANGING WORLD. THE PROJECT WILL DEVELOP AN EDUCATIONAL PIPELINE FROM STUDENT ADMISSION AND TRAINING TO GRADUATION AND PROFESSIONAL DEVELOPMENT AND ADVANCE THE UNDERSTANDING OF THE DOMINANT FACTORS THAT INCREASE THE ACADEMIC AND PROFESSIONAL SUCCESS OF LOW-INCOME STUDENTS. A MENTORING SYSTEM AND A NETWORKED SUPPORTING COMMUNITY THAT INTEGRATE CAMPUS RESOURCES AND SUSTAINABILITY ACTIVITIES WILL BE ESTABLISHED FOR IMPROVED CURRICULAR AND CO-CURRICULAR EXPERIENCES. THE PROJECT IS EXPECTED TO BROADEN THE PARTICIPATION OF LOW-INCOME STUDENTS IN ENVIRONMENTAL AND EARTH SCIENCE BY REDUCING FINANCIAL PRESSURE, INCREASING LEARNING OPPORTUNITIES AND OUTCOMES, AND BRIDGING OVERALL CAREER SUCCESS. IT WILL ALSO ADVANCE THE MISSION OF U.S. INSTITUTIONS OF HIGHER EDUCATION THAT TRAIN A DIVERSE AND GLOBALLY COMPETITIVE STEM WORKFORCE IN SUSTAINABLE ENVIRONMENTAL AND EARTH SCIENCE. THE OVERALL GOAL OF THIS PROJECT IS TO INCREASE STEM DEGREE COMPLETION OF LOW-INCOME, HIGH-ACHIEVING UNDERGRADUATES WITH DEMONSTRATED FINANCIAL NEED. SPECIFIC OBJECTIVES INCLUDE: (1) INCREASING EDUCATIONAL OPPORTUNITIES FOR ACADEMICALLY TALENTED STUDENTS WITH FINANCIAL NEED, (2) IMPROVING EDUCATIONAL SUPPORT PROGRAMS AT SIUC, (3) IMPROVING THE RETENTION OF STUDENTS IN THE SIUC SCHOOL OF EARTH SYSTEMS AND SUSTAINABILITY, AND (4) ENHANCING THE FUTURE STEM WORKFORCE WITH SKILLS IN EARTH SCIENCE AND SUSTAINABILITY. TO ADDRESS THE HISTORIC DISCONNECT BETWEEN SUSTAINABILITY AND EARTH SCIENCE TRAINING, IT IS VITAL TO INTEGRATE SUSTAINABILITY INTO EARTH SCIENCE EDUCATION IN INSTITUTES OF HIGHER EDUCATION. ADVANCING UNDERSTANDING OF HOW SUPPORTING SERVICES AND PROGRAMS DRIVE ACADEMIC SUCCESS IN GEOSCIENCE MAJORS, ESPECIALLY FOR TRANSFER STUDENTS, IS ALSO CRITICAL. THIS PROJECT WILL ESTABLISH AN EDUCATIONAL PROTOTYPE THAT SUCCESSFULLY SUPPORTS ACADEMICALLY TALENTED AND LOW-INCOME TRANSFER STUDENTS TO BECOME SUSTAINABILITY-FOCUSED EARTH SCIENCE DEGREE GRADUATES. FOLLOWING THE THEORY OF PLANNED BEHAVIORS, THE SUPPORTING SERVICE AND ACTIVITIES TO ENHANCE ATTITUDES, SUBJECTIVE NORMS, AND PERCEIVED BEHAVIORAL CONTROL WILL BE FRAMED AS THREE CRITICAL CONSTRUCTS THAT ARE EXPECTED TO DRIVE STUDENTS? POSITIVE INTENTIONS FOR GRADUATION. THE PROJECT HOPES TO CREATE AN INCLUSIVE AND DIVERSE LEARNING COMMUNITY AND INFRASTRUCTURE TO ADVANCE THE PROJECT GOALS AND MISSIONS. IT IS EXPECTED THAT 40 LOW-INCOME ACADEMICALLY TALENTED TRANSFER STUDENTS WILL BE AWARDED $10,000 SCHOLARSHIPS EACH YEAR AND THAT AN OVERALL 85% RETENTION RATE AND 80% GRADUATION RATE WILL BE ACHIEVED. THE PROJECT WILL UTILIZE A MANAGEMENT-ORIENTED FORMATIVE AND SUMMATIVE EVALUATION APPROACH. RESULTS WILL BE DISSEMINATED INTERNALLY TO THE OFFICE OF THE PROVOST AND FACULTY MEMBERS AT SIUC AND SHARED EXTERNALLY TO THE STEM COMMUNITY THROUGH STEM CENTRAL, SOCIAL MEDIA, PROFESSIONAL CONFERENCES, AND PUBLICATIONS IN STEM EDUCATION JOURNALS. THIS PROJECT IS FUNDED BY NSF?S SCHOLARSHIPS IN SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS PROGRAM, WHICH SEEKS TO INCREASE THE NUMBER OF LOW-INCOME ACADEMICALLY TALENTED STUDENTS WITH DEMONSTRATED FINANCIAL NEED WHO EARN DEGREES IN STEM FIELDS. IT ALSO AIMS TO IMPROVE THE EDUCATION OF FUTURE STEM WORKERS, AND TO GENERATE KNOWLEDGE ABOUT ACADEMIC SUCCESS, RETENTION, TRANSFER, GRADUATION, AND ACADEMIC/CAREER PATHWAYS OF LOW-INCOME STUDENTS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

CCAMPIS

ENVIRONMENTAL HEALTH INVESTIGATORS: BUILDING STEM INTEREST TO PROMOTE CAREERS IN THE HEALTH SCIENCES

UPWARD BOUND MATH AND SCIENCE COMPETITION

CIRCADIAN CLOCK DISRUPTION: A MECHANISM FOR DIOXIN-INDUCED METABOLIC SYNDROME

THE GLYCINE RECEPTOR IN A RAT TINNITUS MODEL: A POSSIBLE THERAPEUTIC TARGET

COLLABORATIVE RESEARCH: DEVELOPING STEM EDUCATION REFORM LEADERS THROUGH A MULTIDISCIPLINARY AND CROSS-INSTITUTIONAL COMMUNITY OF TRANSFORMATION -THIS PROJECT AIMS TO SERVE THE NATIONAL INTEREST BY SYSTEMATICALLY SCALING UP EVIDENCE-BASED TEACHING PRACTICES IN SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS (STEM) COURSES ACROSS A DIVERSE SET OF INSTITUTIONS AND BY INVESTIGATING FACTORS ASSOCIATED WITH EFFECTIVE EDUCATIONAL INTERVENTIONS. TO UNDERSTAND AND ASSESS THESE FACTORS, THE COLLABORATIVE RESEARCH PROJECT INTENDS TO RIGOROUSLY IMPLEMENT AND INVESTIGATE A RECOGNIZED EFFECTIVE TEACHING PRACTICE, FLIPPED INSTRUCTION, IN WHICH STUDENTS APPLY KNOWLEDGE FROM WELL-STRUCTURED MATERIALS TO ACTIVE LEARNING SITUATIONS DURING CLASS TIME. A TEAM OF FACULTY AND RESEARCHERS FROM SOUTHERN ILLINOIS UNIVERSITY - EDWARDSVILLE, NORTHEASTERN ILLINOIS UNIVERSITY, SOUTHERN ILLINOIS UNIVERSITY CARBONDALE, AND CHICAGO STATE UNIVERSITY AND THEIR COMMUNITY COLLEGE PARTNERS, ST. LOUIS COMMUNITY COLLEGE, CITY COLLEGES OF CHICAGO-MALCOLM X COLLEGE, OAKTON COLLEGE, AND SHAWNEE COMMUNITY COLLEGE INTEND TO CONDUCT A WIDE-RANGE OF PROFESSIONAL DEVELOPMENT ACTIVITIES. THEY ALSO AIM TEST A MODEL OF PROFESSIONAL DEVELOPMENT, AND DETERMINE THE EFFECTS OF INSTITUTIONAL, DISCIPLINARY, INSTRUCTOR, AND STUDENT CHARACTERISTICS ON THE EFFECTIVENESS OF FLIPPED INSTRUCTION IN STEM UNDERGRADUATE EDUCATION. FOUR PAIRINGS OF INSTITUTIONS - EACH PAIR INCLUDING A 4-YEAR INSTITUTION AND A 2-YEAR INSTITUTION - CONSTITUTE THE FOUNDATION FOR BOTH IMPLEMENTATION AND INVESTIGATION. FLIPPED INSTRUCTION HAS DEMONSTRATED ITS POTENTIAL TO SIGNIFICANTLY TRANSFORM TEACHING AND LEARNING IN UNDERGRADUATE STEM EDUCATION. DRAWING ON EXTENSIVE RESEARCH AND FINDINGS FROM A PRIOR NSF IUSE EXPLORATORY AWARD, THIS TRACK 2 INSTITUTIONAL AND COMMUNITY TRANSFORMATION LEVEL II COLLABORATIVE RESEARCH PROJECT INTENDS TO (1) MONITOR STUDENT- CENTERED ORIENTATION OF FACULTY, IMPLEMENTATION, AND VARIATIONS IN IMPLEMENTATION BASED ON INSTITUTIONAL TYPE, DEPARTMENT/DISCIPLINE, AND STUDENT DEMOGRAPHICS; (2) IDENTIFY ENABLERS AND OBSTACLES; AND (3) EXAMINE CHANGE LEADERSHIP AS FOUNDATIONAL STRATEGIES FOR DEVELOPING A COMMUNITY OF PRACTICE. ACTIVITIES HAVE BEEN DESIGNED TO ENHANCE INSTRUCTOR EXPERTISE AND SKILLS IN FLIPPED INSTRUCTION TO MEET THE NEEDS OF STUDENTS AND LEADERSHIP TO DRIVE TRANSFORMATIVE, LASTING CHANGE WITHIN THE RESPECTIVE INSTITUTIONS. GROUNDED IN A COMMUNITIES OF TRANSFORMATION PERSPECTIVE, THE MIXED METHODS RESEARCH DESIGN USES RIGOROUS DATA COLLECTION, ANALYSIS, AND INTERPRETATION METHODS. THE TEAM WILL DOCUMENT AND ASSESS INSTRUCTORS' CONFIDENCE, ATTITUDES, AND MOTIVATIONS TO USE FLIPPED INSTRUCTION, AS WELL AS STUDENTS' ACADEMIC PERFORMANCE AND PERSISTENCE IN STEM. THE INNOVATIVE COLLABORATION OF EIGHT INSTITUTIONS (FOUR PAIRS) INCLUDES INTENTIONALLY DESIGNED TRAINING FOR EFFECTIVE STEM TEACHING, WHILE THE RESEARCH SEEKS TO ADDRESS DIFFERENTIAL EFFECTS ACROSS INSTITUTIONS AND FIND SOLUTIONS THAT STRENGTHEN STEM EDUCATION. THE PROJECT WILL IDENTIFY ENABLERS AND CHALLENGES TO LASTING CHANGE IN UNDERGRADUATE STEM EDUCATION, BOTH AT THE FOUR-YEAR AND COMMUNITY COLLEGE LEVELS. THE NSF IUSE: EDU PROGRAM SUPPORTS RESEARCH AND DEVELOPMENT PROJECTS TO IMPROVE THE EFFECTIVENESS OF STEM EDUCATION FOR ALL STUDENTS. THROUGH THE INSTITUTIONAL AND COMMUNITY TRANSFORMATION TRACK, THE PROGRAM SUPPORTS EFFORTS TO TRANSFORM AND IMPROVE STEM EDUCATION ACROSS INSTITUTIONS OF HIGHER EDUCATION AND DISCIPLINARY COMMUNITIES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

TRIO VETERANS UPWARD BOUND

TRIO UPWARD BOUND SCHOLARS ACADEMY

SIUE NOYCE SCHOLARSHIP PROGRAM: PREPARING FUTURE SCIENCE TEACHERS FOR SOUTHWESTERN ILLINOIS

FIRST PRINCIPLES BASED SIMULATION OF HYDROGEN INTERACTIONS IN COMPLEX HYDRIDES

RESEARCH IN PERVENTION AND TREATMENT OF NOISE-INDUCED HEARING LOSS (NHL)

BEHAVIORAL HEALTH WORKFORCE EDUCATION AND TRAINING (BHWET) PROGRAM

DNA MISMATCH REPAIR IN THE NUCLEOSOMAL ENVIRONMENT

NOVEL MECHANISMS IN DNA MISMATCH REPAIR

RONALD E. MCNAIR POST-BACCALAUREATE ACHIEVEMENT

UPWARD BOUND PROGRAM

NURSE EDUCATION, PRACTICE, QUALITY, AND RETENTION - INTERPROFESSIONAL COLLBORATIVE PRACTICE

SIUC MCNAIR SCHOLARS PROJECT

BEHAVIORAL HEALTH WORKFORCE EDUCATION AND TRAINING FOR PROFESSIONALS AND PARAPROFESSIONALS

SUPPORT OF THE "MONITORING POPULATION STATUS AND MOVEMENT OF NATIVE AND NON-NATIVE FISHES IN THE UPPER, MIDDLE, AND LOWER MISSISSIPPI RIVER"

RONALD E. MCNAIR POSTBACCALAUREATE ACHIEVEMENT

UPWARD BOUND PROGRAM, EAST ST. LOUIS HIGH SCHOOL SCHOLARS ACADEMY

SOUTHERN ILLINOIS UNIVERSITY MCNAIR SCHOLARS PROJECT

SINGLE-MOLECULE APPROACHES TO STUDY EPIBLAST STEM CELL FATE DECISION - PROJECT SUMMARY TISSUE AND ORGAN FAILURE, EITHER DUE TO INJURY OR AGING, ARE BECOMING A MAJOR HEALTH PROBLEM WORLDWIDE WITH AN ESTIMATED COST OF ONE-HALF OF THE TOTAL ANNUAL HEALTHCARE EXPENSES. TO ADDRESS THIS ISSUE, TISSUE ENGINEERING APPROACHES CAN BE LEVERAGED BY UTILIZING FUNCTIONAL BODY CELLS CREATED IN A LABORATORY SETTING. PLURIPOTENT EPIBLAST STEM CELLS (EPISCS) CAN SERVE AS AN EXCELLENT MODEL TO DETERMINE HOW TO DIRECT CELL FATE FOR CREATING FUNCTIONAL BODY CELLS. HOWEVER, EVEN WITH THE BEST CHEMICALLY-DEFINED DIFFERENTIATION PROTOCOL OF PLURIPOTENT STEM CELLS, THE CONTROL OF CELL-LINEAGE SPECIFICATION REMAINS POOR. BESIDES CHEMICAL SIGNALING, IT IS NOW WIDELY ACCEPTED THAT PHYSICAL SIGNALS FROM THE EXTRACELLULAR MATRIX (ECM) PLAY A CRUCIAL ROLE IN CELL FATE DETERMINATION. NEVERTHELESS, CONTROL OF CELL-LINEAGE SPECIFICATION BY SUCH MECHANICAL FORCES ALONE COULD NOT BE IMPROVED POSSIBLY DUE TO THE LACK OF PRECISE CONTROL OF FORCES AT THE SINGLE-MOLECULE LEVEL AND THE LACK OF SYNERGY BETWEEN CHEMICAL SIGNALING AND MECHANICAL PATHWAYS. TO ADDRESS THIS GAP, THE PROPOSED STUDY AIMS TO PROVIDE A MECHANISTIC FRAMEWORK OF SINGLE EPISC FATE DECISIONS (SELF-RENEWAL AND DIFFERENTIATION) BASED ON CHEMICAL AND SINGLE-MOLECULE FORCE BASED APPROACHES. THE CENTRAL HYPOTHESIS IS THAT THE SYNERGISTIC EFFECT OF CHEMICAL AND SINGLE-MOLECULE FORCE CUES VIA CELL-ECM AND CELL-CELL INTERACTIONS CAN CONTROL FATE DECISIONS FAR MORE EFFECTIVELY THAN PREVIOUSLY POSSIBLE. THE LONG-TERM GOAL IS TO DEVELOP NOVEL APPROACHES TO CONTROL THE DIRECTED DIFFERENTIATION OF PLURIPOTENT CELLS INTO ALL THREE GERM-LAYERS. TO THIS END, THE FOLLOWING THREE AIMS ARE PROPOSED. SPECIFICALLY, AIM 1 WILL FOCUS ON UNDERSTANDING THE MECHANISM OF SINGLE-MOLECULE FORCE MEDIATED DIFFERENTIATION OF EPISCS INTO THE MESODERM LINEAGE. THE FORCE TRANSMISSION INTO SINGLE CELLS VIA SINGLE AVSS3 INTEGRINS WILL BE CONTROLLED BY TENSION GAUGE TETHERS. THESE DNA-BASED RUPTURABLE TETHERS CAN PRECISELY LIMIT THE AMOUNT OF FORCE AT THE SINGLE-MOLECULE LEVEL. TOGETHER WITH CHEMICAL SIGNALING, SUCH PRECISE CONTROL AND SPECIFIC TARGETING OF MECHANICAL PATHWAYS MAY LEAD TO SUPERIOR CONTROL OF CELL DIFFERENTIATION INTO THE MESODERM. IN AIM 2, THE MECHANISM OF SELF-RENEWAL OF SINGLE EPISCS WILL BE IDENTIFIED BY DEFINING A MICROENVIRONMENT COMPOSED OF SELF-RENEWAL PROMOTING LIGANDS SUCH AS E-CADHERIN. IN AIM 3, DIFFERENTIATION OF SINGLE EPISCS WILL BE DEFINED VIA THE NOTCH PATHWAY BY ENGINEERED LOW- TOLERANCE TENSION GAUGE TETHER CALLED “NANO-YOYO” TO ACTIVATE FORCE-DEPENDENT NOTCH SIGNALING. THE PROPOSED WORK WILL ELUCIDATE DETAILED MOLECULAR, CHEMICAL, AND MECHANICAL PATHWAYS THAT CONTRIBUTE TO SPECIFIC LINEAGE COMMITMENTS. FINALLY, THREE UNDERGRADUATE AND TWO GRADUATE STUDENTS WILL GAIN RESEARCH EXPERIENCE IN RIGOROUS AND INTENSIVE RESEARCH IN THE AREAS OF STEM CELLS, CELL MECHANICS, AND BIOPHYSICS. STUDENTS WILL CONDUCT EXPERIMENTS, ANALYZE AND SUMMARIZE DATA, AND PREPARE MANUSCRIPTS SIMULTANEOUSLY ADVANCING THE PROPOSED SCIENTIFIC AGENDA.

15-LIPOXYGENASE-2 (ALOX15B) AS A TUMOR SUPPRESSOR

TRIO - STUDENT SUPPORT SERVICES - STUDENT SUPPORT SERVICES PROGRAM

PURPOSE: THE PRIMARY OBJECTIVE OF THE COLLABORATIVE SURVEILLANCE EFFORT BETWEEN APHIS, WS AND THE COOPERATOR IS TO IMPROVE UNDERSTANDING OF SPATIAL, TEMPORAL, AND EVOLUTIONARY DYNAMICS OF SARS-COV-2 IN WHITE-TAILED DEER (WTD) POPULATIONS, AND TO UNDERSTAND WTD MOVEMENT AND BEHAVIOR THAT AFFECT DISEASE PREVALENCE. ACTIVITIES TO BE PERFORMED: THE COLLABORATIVE EFFORT WILL LIVE-SAMPLE WTD POPULATIONS FOR SARS-COV-2 INTENSIVELY OVER TIME WHILE MONITORING THEIR MOVEMENTS AND INTERACTIONS. EXPECTED OUTCOMES: THIS APPROACH WILL IDENTIFY DRIVERS OF TRANSMISSION AND PERSISTENCE OF SARS-COV-2 IN WTD POPULATIONS AND PROVIDE DATA FOR OPTIMIZING RISK-BASED SURVEILLANCE DESIGNS AND DEVELOPING NEW ANALYTICAL TOOLS FOR ONE HEALTH MANAGEMENT. INTENDED BENEFICIARIES: AMERICAN AGRICULTURE, HUMAN HEALTH, ANIMALS, AND THE ENVIRONMENT. SUBRECIPIENT ACTIVITIES: THE RECIPIENT DOES NOT INTEND TO SUBAWARD FUNDS.

UNDERSTANDING COMPOUND PHASE TRANSITION IN NEW HEUSLER ALLOY COLOSSAL MAGNETOCALORIC MATERIALS

PREPARING MATHEMATICS TEACHERS FOR SOUTHWESTERN ILLINOIS

A YOUTH-LED CITIZEN SCIENCE NETWORK FOR COMMUNITY ENVIRONMENTAL ASSESSMENT

NICOTINE FOR MARIJUANA WITHDRAWAL

AMERICAN RESCUE PLAN

HEALTH CENTER CORONAVIRUS AID, RELIEF, AND ECONOMIC SECURITY (CARES) ACT FUNDING

CONGRESSIONALLY DIRECTED SPENDING FOR CONSTRUCTION PROJECTS

NURSE EDUCATION, PRACTICE, QUALITY AND RETENTION - WORKFORCE EXPANSION PROGRAM - RURAL COMMUNITIES FACE MORE SIGNIFICANT NURSING SHORTAGES THAN THE NATIONAL AVERAGE, IMPACTING THE QUALITY AND ACCESSIBILITY OF HEALTHCARE SERVICES. EVIDENCE SHOWS THAT STUDENTS FROM RURAL AREAS OFTEN RETURN TO THEIR OWN COMMUNITIES UPON DEGREE COMPLETION, MAKING IT CRUCIAL TO RECRUIT AND RETAIN STUDENTS FROM THESE LOCATIONS. LIMITED FINANCIAL RESOURCES AND LACK OF KNOWLEDGE ABOUT PATHWAYS TO NURSING DEGREE COMPLETION CONTRIBUTE TO THESE SHORTAGES. ADDITIONALLY, THERE IS A NEED FOR INCREASED KNOWLEDGE IN LONG-TERM CARE, GERIATRIC SUPPORT, AND COMMUNITY NURSING TO BETTER SERVE RURAL AND ADJACENT POPULATIONS. THIS PROPOSED PROJECT HAS TWO SPECIFIC AIMS WITH SEVERAL OBJECTIVES TO ACHIEVE THESE AIMS SUCCESSFULLY. AIM 1: EXPAND NURSING WORKFORCE CAPACITY IN RURAL AND LONG-TERM CARE SETTINGS. OBJECTIVES TO ADDRESS AIM 1 INCLUDE: 1) COLLABORATE WITH COMMUNITY COLLEGES, UNIVERSITIES, AND CLINICAL PARTNERS IN RURAL AREAS FOR RECRUITMENT OUTREACH PROGRAMS IN MIDDLE AND HIGH SCHOOLS TO PROMOTE MULTIPLE PATHWAYS TO NURSING DEGREE COMPLETION. 2) IMPLEMENT INTENTIONAL RECRUITMENT EFFORTS FOCUSING ON DIVERSIFYING THE NURSING WORKFORCE. 3) PROVIDE FUNDING OPPORTUNITIES FOR STUDENTS IN THE ACCELERATED POST-BACCALAUREATE NURSING PROGRAM. AIM 2: ENHANCE EDUCATIONAL EXPERIENCES THROUGH TRAINING AND EXPERIENTIAL LEARNING ACTIVITIES FOCUSED ON RURAL AND LONG-TERM CARE READINESS. OBJECTIVES TO ADDRESS AIM 2 INCLUDE: 1) COLLABORATE WITH COMMUNITY COLLEGES, UNIVERSITIES, AND CLINICAL PARTNERS IN RURAL AND LONG-TERM CARE SETTINGS TO PROVIDE CLINICAL ROTATIONS IN LONG-TERM CARE AND CRITICAL ACCESS HEALTHCARE DELIVERY CENTERS. 2) DEVELOP AND IMPLEMENT TRAINING PROGRAMS IN COLLABORATION WITH MULTIPLE CLINICAL PARTNERS AND COLLEGES THAT ENHANCE CRITICAL THINKING, UNDERSTANDING OF SOCIAL DETERMINANTS OF HEALTH, LEADERSHIP, AND COMMUNICATION SKILLS. 3) INCORPORATE VIRTUAL REALITY AND HANDS-ON SIMULATION EXPERIENCES INTO THE CURRICULUM WITH AN EMPHASIS ON COMMUNITY AND GERIATRIC CARE. BY ADDRESSING THESE CRITICAL NEEDS, THE PROJECT AIMS TO BUILD A ROBUST AND DIVERSE NURSING WORKFORCE EQUIPPED TO DELIVER HIGH-QUALITY HEALTHCARE IN RURAL AND UNDER-SERVED REGIONS. THROUGH COLLABORATIVE EFFORTS, TARGETED RECRUITMENT, AND COMPREHENSIVE EDUCATIONAL SUPPORT, THIS INITIATIVE WILL CONTRIBUTE TO THE SUSTAINABILITY AND EFFECTIVENESS OF HEALTHCARE DELIVERY IN THESE COMMUNITIES. FUNDING PRIORITY #2 AND FUNDING PREFERENCE - QUALIFICATION #1 REQUESTED.

COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - NON-CONSTRUCTION

SOUTHERN ILLINOIS ENERGY SCHOLARSHIPS

PATHWAYS TO STEM LEADERSHIP CAREERS

REGULATORY MECHANISMS OF EUKARYOTIC TRANSCRIPTIONAL ACTIVATION BY THE 19S PROTEAS

ADVANCE ADAPTATION: TOWARD AN INCLUSIVE MODEL OF EXCELLENCE IN STEM

CONGRESSIONALLY DIRECTED SPENDING FOR CONSTRUCTION PROJECTS

CELL-TYPES SPECIFIC NEUROADAPTATIONS IN THE NUCLEUS ACCUMBENS SHELL ASSOCIATED WITH INDIVIDUAL DIFFERENCES IN COCAINE-SEEKING - PROJECT SUMMARY/ABSTRACT ALTHOUGH COCAINE IS POWERFULLY REWARDING, NOT ALL PEOPLE WHO ARE EXPOSED TO THIS DRUG ARE EQUALLY PRONE TO ABUSING IT. THE REASONS FOR THESE DIFFERENCES REMAIN UNKNOWN BUT MAY INVOLVE PREDISPOSING FACTORS WHOSE ELUCIDATION COULD LEAD TO THERAPIES THAT, IN THE FUTURE, MAY PREVENT COCAINE ADDICTION. ONE SUCH PREDISPOSING FACTOR IS BEHAVIORAL SENSITIVITY TO THE AVERSIVE ATTRIBUTES OF COCAINE, WHICH OVERLAP WITH THE REWARDING EFFECTS TO PROTECT AGAINST COCAINE-SEEKING. PRELIMINARY DATA IN THIS PROPOSAL SUGGEST THAT THE AVERSIVE EFFECT OF COCAINE MAY BE MUCH STRONGER IN SOME INDIVIDUALS THAN OTHERS AND POTENTIALLY A DETERMINANT FOR COCAINE ADDICTION VULNERABILITY. THE UNDERLYING CELLULAR MECHANISM OF THIS VARIABILITY REMAINS UNKNOWN. HOWEVER, OUR PRELIMINARY DATA REVEALED THAT HIGHER RHOA ACTIVITY AND D2-MSN EXCITABILITY IN THE MNACSHELL CORRELATE WITH RATS DISPLAYING HIGHER AVERSIVE EFFECTS OF COCAINE (AND CONSEQUENTLY LOWER DRIVE TO SEEK COCAINE). NEVERTHELESS, IT IS UNKNOWN IF THESE CELLULAR AND MOLECULAR ADAPTATIONS IN THE MNACSHELL ARE INVOLVED IN THE AVERSIVE ATTRIBUTES OF COCAINE. ACCORDINGLY, TO ADDRESS THIS GAP IN KNOWLEDGE, I’M PROPOSING TWO AIMS. IN AIM 1, I WILL DETERMINE THE ROLES OF D2MSN ON COCAINE AVOIDANCE BEHAVIOR, AND FOR THIS, I WILL BE TRAINED IN FIBER PHOTOMETRIC AND OPTOGENETIC METHODS. I HYPOTHESIZE THAT D2- BUT NOT D1-MSNS ARE ACTIVATED DURING COCAINE’S AVERSIVE PHASE, AND THAT D2 ACTIVITY IN TURN DRIVES CONDITIONED NEGATIVE ATTRIBUTES OF COCAINE. IN AIM 2, I WILL EXAMINE THE ROLES OF RHOA AND RELATED GENES ON NEURAL EXCITABILITY AND COCAINE AVOIDANCE IN A CELL-SPECIFIC MANNER. FIRST, I WILL USE MRNA TRAP METHODS TO ANALYZE CELL-SPECIFIC GENE TRANSLATION ASSOCIATED WITH RHOA SIGNALING OR EXCITABILITY LINKED TO COCAINE AVOIDANCE PHENOTYPES. IN ADDITION, TO TEST THE CAUSAL ROLE OF RHOA IN EXCITABILITY AND COCAINE AVOIDANCE BEHAVIOR, I WILL DECREASE OR INCREASE RHOA ACTIVITY IN A CELL-SPECIFIC MANNER USING AN ADENO-ASSOCIATED GENE MANIPULATION STRATEGY. I HYPOTHESIZE THAT INCREASES IN RHOA ACTIVITY IN D2-MSN BUT NOT D1-MSN ENHANCES EXCITABILITY IN THE MNACSHELL CONFER PROTECTION AGAINST THE ACQUISITION OF COCAINE-SEEKING. AN INTENSE AND COMPREHENSIVE TRAINING, MENTORING, AND RESEARCH PLAN HAS BEEN DEVELOPED TO ACHIEVE THESE GOALS. THIS PLAN WILL BE GUIDED BY A POWERFUL TEAM OF MENTORS AND COLLABORATORS THAT WILL HELP BLEND MY CURRENT SKILL SET WITH NEW CONCEPTUAL AND TECHNICAL FRAMEWORKS AS I CONTINUE TO ESTABLISH MY OWN UNIQUE AND INNOVATIVE RESEARCH PROGRAM IN ADDICTION NEUROSCIENCE.

TARGETING THE RELIEF OF CHRONIC PAIN WITH ORALLY ACTIVE PEROXYNITRITE DECOMPOSITI

RNA SPLICING IN ARCHAEA

SOLARSTEAM

MECHANISM OF TUMOR METASTASES SUPPRESSION BY DRG1

TALENT SEARCH PROGRAM

A NOVEL GABAA RECEPTOR SUBTYPE IN AUDITORY THALAMUS: A POTENTIAL NEW TARGET FOR TINNITUS TREATMENT

UPWARD BOUND MATH & SCIENCE

REHABILITATION LONG-TERM TRAINING - REHABILITATION COUNSELING

INVESTIGATING HOW CHROMATIN REMODELING AFFECTS ENDOCYTOSIS AND SYNAPTIC ORGANIZATION

UPWARD BOUND PROGRAM AT BROOKLYN, EAST ST. LOUIS CHARTER, AND MADISON HIGH SCHOOLS (BEM)

UPWARD BOUND MATH AT SCIENCE AT EAST ST. LOUIS, CAHOKIA AND MADISON HIGH SCHOOLS

HEALTH CENTER INFRASTRUCTURE SUPPORT

BEHAVIORAL HEALTH WORKFORCE EDUCATION AND TRAINING (BHWET) PROGRAM

ARYL HYDROCARBON RECEPTOR REGULATION OF ENERGY METABOLISM

ZOONIVERSE: GUERRILLA CITIZEN SCIENCEIN TODAY'S TECHNOLOGY DRIVEN SCIENCE, RESEARCHERS OFTEN FIND THEMSELVES INUNDATED WITH DATA REQUIRING HUMAN EYE

NURSE EDUCATION PRACTICE QUALITY AND RETENTION- REGISTERED NURSE TRAINING PROGRAM - THIS PROPOSED PROJECT HAS FOUR SPECIFIC AIMS (THE 4 RS). TO RECRUIT AND RETAIN A DIVERSE STUDENT NURSE POPULATION, TO ENSURE READINESS TO PRACTICE IN ACUTE CARE SETTINGS, AND TO REVISE CURRICULAR PROGRAMS TO EMPHASIZE AWARENESS AND MANAGEMENT OF THE EFFECTS OF SOCIAL DETERMINANTS OF HEALTH ON PATIENT OUTCOMES. AIM 1: RECRUITMENT OF PROSPECTIVE STUDENTS AND NURSE EDUCATORS WITH AN EMPHASIS ON DIVERSIFYING THE NURSING WORKFORCE. AIM 2: RETENTION OF PRE-NURSING AND NURSING STUDENTS AT A STATE PUBLIC UNIVERSITY. AIM 3: READINESS TO PRACTICE THROUGH A PROGRAM FOCUSING ON ENHANCING THE UNDERGRADUATE NURSING PROGRAM EXPERIENCE TO ENSURE COMPETENCY AND CONFIDENCE IN PRACTICE ENTRY IN ACUTE CARE SETTINGS UPON GRADUATION. AIM 4: REVISION OF OUR NURSING SCHOOL CURRICULUM TO ADDRESS PRINCIPLES OF THE SOCIAL DETERMINANTS OF HEALTH WITH THE GOAL OF IMPROVEMENT IN PATIENT OUTCOMES AND HEALTH LITERACY, AND REDUCTION IN HEALTH INEQUITIES. EVIDENCE HAS SHOWN THAT CLIENT TRUST AND PATIENT OUTCOMES ARE IMPROVED WHEN HEALTH CARE PROFESSIONALS ARE REPRESENTATIVE OF THE NATURAL VARIATIONS WITHIN THE POPULATION. THERE IS ALSO AN ONGOING, SIGNIFICANT NURSING SHORTAGE MAKING IT IMPERATIVE THAT ACADEMIC AND CLINICAL COLLABORATIONS ARE IN PLACE TO ENSURE READINESS TO PRACTICE FOR NEW GRADUATE NURSES. EVIDENCE SHOWS THAT CLINICAL, CLASSROOM AND SIMULATION EXPERIENCES THAT EMPHASIZE CONCEPTS FROM SOCIAL DETERMINANTS OF HEALTH PREPARE UNDERGRADUATE NURSES FOR APPROPRIATE AND INCLUSIVE CARE OF DIVERSE POPULATIONS. IN ADDITION, LITERATURE IS ABUNDANT WITH STRATEGIES TO RECRUIT AND RETAIN NURSES OF DIVERSE BACKGROUNDS WHICH INCLUDES MENTORING, ACADEMIC, SOCIAL AND PERSONAL ADVISING, AND SUPPORTIVE ACADEMIC ENVIRONMENTS. OBJECTIVES OF THIS PROJECT INCLUDE: 1) RECRUITMENT OF DIVERSE NURSING STUDENTS THROUGH DEVELOPMENT OF A SCHOOL PIPELINE IN COLLABORATION WITH SCHOOL DISTRICTS AND LOCAL HOSPITALS TO FACILITATE AWARENESS OF THE NURSING PROFESSION BY OFFERING SHADOWING EXPERIENCES AND MOBILE SIMULATION EXPERIENCES. ADDITIONAL EFFORTS TO INCREASE DIVERSE NURSING FACULTY INCLUDE NATIONAL RECRUITMENT EFFORTS AND DEVELOPMENT OF NURSE EDUCATOR FELLOWSHIPS TO ASSIST IN DEGREE COMPLETION, RESEARCH EFFORTS OR FACULTY DEVELOPMENT GOALS; 2) RETENTION OF PRE-NURSING STUDENTS THROUGH COLLABORATION WITH OUR SCIENCE DEPARTMENT TO INTEGRATE AN EVIDENCE-BASED PEER LED TEAM LEARNING MODEL THAT IS WELL-KNOWN TO IMPACT STUDENT SUCCESS; 3) RETENTION OF STUDENTS BY INCREASING RESOURCES FOR OUR STUDENT SUCCESS TEAM WITHIN THE NURSING PROGRAM AS WELL AS OUR ALREADY ESTABLISHED AND SUCCESSFUL STUDENT NURSE ACHIEVEMENT PROGRAM (SNAP); 4) ENHANCED READINESS TO PRACTICE THROUGH COLLABORATIONS WITH HOSPITALS LOCATED IN UNDERSERVED AREAS TO FOSTER INNOVATIVE CLINICAL EXPERIENCES THAT INVOLVE A NURSE PRECEPTOR MODEL. ADDITIONAL MODIFICATIONS TO FINAL SEMESTER COURSES WILL ALSO INCLUDE COMPONENTS OF NEW GRADUATE ORIENTATION BASED ON INPUT FROM COLLABORATING HOSPITALS TO DECREASE ORIENTATION TIME INTO NURSING PRACTICE; 5) REVISION OF NURSING CURRICULUM TO FULLY INTEGRATE SOCIAL DETERMINANTS OF HEALTH INTO CLASS, CLINICAL AND SIMULATION EXPERIENCES.

DIGITAL EAST ST. LOUIS: AN URBAN PLACE-BASED LEARNING MODEL TO PROMOTE INFORMATION TECHNOLOGY AND COMPUTER SCIENCE CAREER INTERESTS OF MINORITY YOUTH

INTEGRATING COMPUTATIONAL THINKING INTO A MINORITY GIRLS PROGRAM ON GLOBAL CHALLENGES

CHILDCARE ACCESS MEANS PARENTS IN SCHOOL - CHILD CARE

UNRAVELING THE ROLE OF PROTEIN PHOSPHORYLATION IN THE REGULATION OF DEVELOPMENT I

NEW; TITLE: PROFESSIONAL SCIENCE MASTER'S IN ADVANCED ENERGY AND FUELS MANAGEMENT PROGRAM; PI: JOHN KOROPCHAK

STUDENT TEAMS ENGAGING PEERS FOR UNDERGRADUATE PROGRESS (STEP-UP)

COMMUNICATION BETWEEN NEIGHBORING RYANODINE RECEPTOR CHANNELS IN SKELETAL MUSCLE

RESEARCH ENTITLED: QUALIFICATIONS OF CANDLE FILTERS FOR PFBC APPLICATIONS

DELTA STATE RURAL DEVELOPMENT NETWORK GRANT PROGRAM (DELTA)

"NEW; TOWARDS A SCALABLE AND ADAPTIVE APPLICATION SUPPORT PLATFORM FOR LARGE-SCALE DISTRIBUTED E-SCIENCES IN HIGH-PERFORMANCE NETWORK ENVIRONMENTS; P

PRIMARY CARE TRAINING AND ENHANCEMENT

RURAL COMMUNITIES OPIOID RESPONSE-IMPLEMENTATION

** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THANKS TO ADVANCEMENTS IN COMPUTATIONAL POWER, AGRICULTURISTS CAN NOW USE RICH DATA SOURCES TO EXPLORE NOVEL WAYS TO OPTIMIZE, IMPROVE, AND SUSTAIN PLANT PRODUCTION SYSTEMS. TO MEET THIS NEED, EMPLOYMENT OPPORTUNITIES FOR DATA SCIENTISTS ARE EXPECTED TO GROW BY 36% OVER THE NEXT DECADE. THE MOST DESIRABLE APPLICANTS FOR THESE POSITIONS WILL BE GRADUATES WHO CAN COLLABORATE EFFECTIVELY WITHIN A TEAM SETTING AND WHO HAVE AN UNDERSTANDING OF BOTH DATA SCIENCE AND THE LABORATORY, FIELD, AND GREENHOUSE SETTINGS WHERE DATA ARE GENERATED.THE OVERALL GOAL OF THIS PROJECT IS TO PROVIDE UNDERGRADUATE EXPERIENTIAL TRAINING OPPORTUNITIES THAT COMBINE DATA SCIENCE AND CROP SCIENCE. THE PROGRAM CONSISTS OF TWO TRACKS: THE EXPLORERS TRACK, AND THE FELLOWS TRACK. EXPLORERS WILL BE INTRODUCED TO THE APPLICATIONS OF DATA SCIENCE IN CROP SCIENCE THROUGH A WEEK-LONG SUMMER DATA SCIENCE BOOTCAMP WHERE THEY WILL USE COMPUTATIONAL SKILLSETS TO DERIVE MEANING FROM REAL-WORLD EXAMPLES, AND THEY WILL WORK IN TEAMS TO PRESENT THE FINDINGS OF THEIR SHORT PROJECTS. STUDENTS IN THE FELLOWS TRACK WILL BE IMMERSED IN A FULLY FUNDED, TWO-YEAR RESEARCH EXPERIENCE. FELLOWS WILL BE PLACED WITH A PROFESSOR IN A RESEARCH AREA OF THEIR CHOOSING TO GAIN PRACTICAL LABORATORY, GREENHOUSE, AND/OR FIELD EXPERIENCE. THEY WILL WORK WITH THEIR MENTORS TO DESIGN AN INDEPENDENT STUDY PROJECT THAT COMBINES THESE RESEARCH SKILLS WITH DATA SCIENCE, AND THEY WILL PRESENT THE RESULTS OF THEIR PROJECT TO THE SCIENTIFIC COMMUNITY AND TO THE PUBLIC. UPON COMPLETION OF THE PROJECT, 200 EXPLORERS AND 16 FELLOWS WILL HAVE BEEN TRAINED.

REHABILITATION LONG-TERM TRAINING - REHABILITATION COUNSELING

THE ROLES OF POLYMERASE GAMMA ACCESSORY SUBUNIT GENE MUTATIONS IN HUMAN DISEASE.

REHABILITATION LONG-TERM TRAINING - REHABILITATION COUNSELING

EXPANDQISE: TRACK 1: INVESTIGATING BIOMASS PRETREATMENT WITH NANODIAMOND QUANTUM SENSORS -NON-TECHNICAL ABSTRACT: LEVERAGING NOVEL QUANTUM SYSTEMS TO REALIZE MEASURING DEVICES BEYOND CLASSICAL CAPABILITIES AND EXPANDING THEIR APPLICATIONS TO A BROADER SCIENTIFIC COMMUNITY IS AT THE HEART OF MODERN QUANTUM SCIENCE. THIS PROJECT EXPLOITS THE POWER OF NANODIAMOND-BASED QUANTUM SENSORS IN THE FIELD OF BIOENERGY RESEARCH TO INVESTIGATE THE BIOMASS PRETREATMENT PROCESS, A CRUCIAL STEP TOWARD THE PRODUCTION OF SUSTAINABLE BIOFUELS. BY DEVELOPING A CELL IMAGING MICROSCOPE WITH QUANTUM SENSING CAPABILITIES, THE RESEARCH TEAM PLANS TO INVESTIGATE THE STRUCTURE CHANGE OF BIOMASS IN REAL-TIME, WHICH WILL HELP TO ACCELERATE THE OPTIMIZATION OF BIOENERGY PRODUCTION EFFICIENCY. ON THE EDUCATIONAL AND OUTREACH FRONT, THE RESEARCH TEAM WILL INTRODUCE THE DEVELOPED QUANTUM IMAGING MICROSCOPE AS A SHARED FACILITY TO THE RESEARCHERS AT SOUTHERN ILLINOIS UNIVERSITY EDWARDSVILLE. MOREOVER, THE RESEARCHER TEAM PLANS TO CREATE A NEW SUMMER COURSE AND RESEARCH EXPERIENCE ON QUANTUM INFORMATION FOR UNDERGRADUATE AND MASTER STUDENTS, WHICH HELPS TO MOTIVATE AND PREPARE THEM TO PIVOT TO THE BRAND-NEW AND EXCITING OPPORTUNITIES ENABLED BY QUANTUM SCIENCE. TECHNICAL ABSTRACT: THE OVERARCHING GOAL OF THIS PROJECT IS TO APPLY QUANTUM-ENABLED SENSING TECHNOLOGY BASED UPON NITROGEN-VACANCY DEFECTS AND OTHER COLOR CENTERS IN NANODIAMONDS TO DIRECTLY VISUALIZE AND IMAGE IN REAL-TIME THE STRUCTURE CHANGE OF LIGNOCELLULOSIC BIOMASS DURING THE PRETREATMENT PROCESS. FIRST, AN EXISTING CELL IMAGING MICROSCOPE AT SOUTHERN ILLINOIS UNIVERSITY EDWARDSVILLE WILL BE MODIFIED AND UPGRADED TO DETECT AND OPTIMIZE NANODIAMOND QUANTUM SENSORS. SECOND, A ROBUST AND EFFICIENT FUNCTIONALIZATION PROCEDURE IS DEVELOPED FOR NANODIAMOND SURFACES TO ATTACH CELLULASE/XYLANASE ENZYMES. FINALLY, THE STRUCTURE CHANGE OF LIGNOCELLULOSIC BIOMASS DURING PRETREATMENT IS IMAGED AND INVESTIGATED, WHICH HELPS TO EXPLORE THE OPTIMAL CONDITIONS FOR PRETREATMENT PROCESSES. COMPARED TO CONVENTIONAL SPECTROSCOPY METHODS FOR THIS TASK, NANODIAMOND QUANTUM SENSORS FEATURE SEVERAL UNIQUE ADVANTAGES: (1) THE ABILITY TO IMAGE AND TRACK IN REAL-TIME BIOMASS COMPONENTS IN SITU; (2) THE POTENTIAL TO LABEL AND DIFFERENTIATE DIFFERENT COMPONENTS OF BIOMASS (CELLULOSE, HEMICELLULOSE, AND LIGNIN) WITH DIFFERENT COLORS OF NANODIAMONDS; (3) THE CAPABILITY TO ACTIVELY MODULATE THE SIGNAL INTENSITY OF NANODIAMONDS SENSORS AND ISOLATE THEM FROM THE BACKGROUND FLUORESCENCE (BACKGROUND-FREE). THIS PROJECT IS JOINTLY FUNDED BY THE OFFICE OF MULTIDISCIPLINARY ACTIVITIES (MPS/OMA), AND THE TECHNOLOGY FRONTIERS PROGRAM (TIP/TF). THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

PUBLIC BROADCASTING SYSTEM GRANT

UNDERSTANDING THE ROLE OF BILE AS A MECHANISM FOR IMPROVED GLUCOSE HOMEOSTASIS FO

HEAD START: FULL YEAR PART DAYHANDICAPPED TRAINING AND TECHNICAL ASSISTANCE

INFLUENCE OF ENDOCRINE DISRUPTORS ON REPRODUCTIVE NEUROENDOCRINE FUNCTION

ADVANCED MICROSCOPE TECHNOLOGIES FOR SINGLE-MOLECULE FUNCTIONAL ANALYSES OF STEREOCILIA COMPONENTS NECESSARY FOR NORMAL HUMAN HEARING - PROJECT SUMMARY/ABSTRACT SENSORINEURAL HEARING LOSS AFFECTS 20% OF THE POPULATION IN THE UNITED STATES AT ALL AGES. A NORMAL ACOUSTIC SENSE REQUIRES A VARIETY OF CELLS IN THE INNER EAR, IN THE BRAIN AND ON NEURONAL PATHWAYS. IN THE INNER EAR, STEREOCILIA ON THE APICAL SURFACE OF HAIR CELLS FUNCTION AS BIOLOGICAL MECHANICAL SWITCHES, AND THEIR DEGENERATION IS ONE OF THE CAUSES OF SENSORINEURAL HEARING LOSS. PRESENTLY, THERE ARE NO CLINICALLY USEFUL TREATMENTS TO REGENERATE OR REPAIR DAMAGED STEREOCILIA. IN THIS K99 PROPOSAL, I DESCRIBE MY ONGOING AND FUTURE STUDIES USING SINGLE-MOLECULE MICROSCOPY TECHNIQUES (1) IN LIVE HAIR CELLS AND (2) IN STEREOCILIA F-ACTIN CORES. I AM ALSO DEVELOPING (3) A NOVEL MOUSE LINE TO VISUALIZE THE DEVELOPMENTAL TRANSITION OF NASCENT MICROVILLI TO MATURE STEREOCILIA AND TO IDENTIFY NOVEL CANDIDATE “DEAFNESS GENES”. SINGLE-MOLECULE MICROSCOPY IN LIVE HAIR CELLS HAS ALREADY YIELDED A NOVEL MODEL TO EXPLAIN THE MOLECULAR DYNAMICS IN STEREOCILIA AND SUCCEEDED IN DETECTING ABNORMAL KINETICS OF MUTANT MOLECULES. WITH THESE TECHNIQUES, I INTRODUCE THE CONCEPT OF “SINGLE-MOLECULE FUNCTIONAL ANALYSIS” TO HEARING RESEARCH AND ANALYZE THE FUNCTIONS OF “DEAFNESS GENE” VARIANTS DISCOVERED IN FAMILIES SEGREGATING HEARING LOSS. THE TRAINING OBJECTIVE IN THIS K99 AWARD IS TO DEVELOP NOVEL MICROSCOPE METHODOLOGIES. SPECIFICALLY, I WILL DEVELOP SINGLE-MOLECULE MICROSCOPY IN LIVE STEREOCILIA BY LEARNING DISPIM LIGHT-SHEET MICROSCOPY AND NEW WAYS OF HIGH-RESOLUTION IMAGING USING DEEP LEARNING FROM DR. HARI SHROFF (NIBIB/NIH), MY CO-MENTOR, WHO IS A WORLD-RENOWNED ENGINEER OF NOVEL MICROSCOPES. I WILL LEARN CRYO-ELECTRON MICROSCOPY (CRYOET) FROM DR. DENNIS C. WINKLER (NIDCD/NIH) TO LOCALIZE SINGLE MOLECULES IN F-ACTIN CORES AND STED SUPER-RESOLUTION MICROSCOPY FROM DR. CHRISTIAN A. COMBS (NHLBI/NIH) TO VISUALIZE THE CHANGE OF MOLECULAR DYNAMICS USING MY NOVEL MOUSE MODELS THAT I AM ESTABLISHING IN THE LABORATORY OF MY NIDCD/NIH MENTOR, DR. THOMAS B. FRIEDMAN. THE RESEARCH AIMS DURING THE MENTORED (K99) PHASE ARE TO ELUCIDATE THE MOLECULAR DYNAMICS OF STEREOCILIA COMPONENTS USING THESE ADVANCED MICROSCOPE TECHNIQUES. SINGLE-MOLECULE MICROSCOPY IN LIVE STEREOCILIA WILL VISUALIZE DYNAMICS OVER THE SHORT TIME SPAN OF SECONDS TO MINUTES. TWO OTHER TECHNIQUES, CRYOET AND STED IN COMBINATION WITH OUR NOVEL MOUSE LINE, WILL ELUCIDATE DYNAMICS OVER A LONGER TIME SPAN DURING REPAIR PROCESSES AND DEVELOPMENT. MOLECULAR DYNAMICS ELUCIDATED BY THESE TECHNIQUES WILL BE A CONTROL TO DETECT ABNORMAL FUNCTIONS OF “DEAFNESS GENE” VARIANTS AS I PROVIDE IN THE PRELIMINARY DATA SECTION. THE AIM DURING THE INDEPENDENT (R00) PHASE IS TO IDENTIFY AND STUDY CANDIDATE “DEAFNESS GENES” AND POTENTIAL THERAPEUTIC TARGETS FOR HUMAN DEAFNESS. I WILL USE MY NOVEL MOUSE MODEL TO STUDY THE CESSATION OF TREADMILLING DURING THE TRANSITION OF MICROVILLI TO STEREOCILIA. BY COMBINING TRANSCRIPTOMICS, I WILL IDENTIFY MOLECULES LOCALIZED IN MICROVILLI WHICH HAVE CEASED NORMAL F-ACTIN TREADMILLING AS THEY TRANSIT TO NASCENT STEREOCILIA. WITH THESE MICROSCOPY TECHNIQUES, I WILL (1) ESTABLISH A PIPELINE TO ANALYZE FUNCTIONS OF STEREOCILIA MOLECULAR COMPONENTS AND (2) REVEAL THERAPEUTIC TARGETS FOR SENSORINEURAL HEARING LOSS.

DEPRESSING NRIP1 REDUCES IGF1 SIGNALING IMPROVES METABOLISM AND EXTENDS LONGEVITY

ADVANCED EDUCATION NURSING TRAINEESHIP

STUDY OF THE US INSTITUTE FOR STUDENT LEADERS IN LOCAL, STATE AND FEDERAL PUBLIC POLICY MAKING

CCAMPIS

CAREER: FRAMEWORK TOPOLOGY DEPENDENT PHOTOPHYSICAL PROPERTIES OF CHROMOPHORE ASSEMBLIES WITHIN METAL-ORGANIC FRAMEWORKS

PROLACTIN FEEDBACK TO HYPOTHALAMIC DOPAMINERGIC NEURONS

COATING EFFECTS ON MR RELAXIVITIES: DENDRON-IRON OXIDE NANOPARTICLE MODELS

TARGETING ATTENTIONAL MECHANISMS IN TINNITUS: CONTRIBUTION OF THE THALAMIC CHOLINERGIC SYSTEM

FUELED BY INNOVATION IN FOOD, AGRICULTURE, NATURAL RESOURCES, HUMAN AND SOCIAL SCIENCES, THIS PROJECT LEVERAGES SIUE'S RESOURCES AND FACULTY EXPERTISE FOR ECONOMIC AND COMMUNITY DEVELOPMENT, IMPROVED JOB CREATION AND RETENTION, AND WORKFORCE EDUCATION. AS A COLLABORATIVE PROJECT WITH THE MONROE COUNTY ECONOMIC DEVELOPMENT CORPORATION AND THE UNIVERSITY OF ILLINOIS EXTENSION OFFICE, THE PROJECT SEAMLESSLY BLENDS EXPERIENTIAL LEARNING, EXTENSION, ECONOMIC DEVELOPMENT, (E3) AND WORKFORCE DEVELOPMENT ACTIVITIES IN AN INTEGRATED PROJECT THAT ADDRESSES GOALS OF REGIONAL AND NATIONAL SCOPE.E3 UTILIZES THE SUCCESSFUL COMMUNITIES FRAMEWORK, AN EVIDENCE-BASED MODEL TO CONNECT BUSINESS AND COMMUNITY NEEDS TO TEAMS OF FACULTY AND STUDENTS WITH THE RESOURCES AND EXPERTISE TO SOLVE THEM. BY TACKLING REAL-WORLD OPPORTUNITIES AND CHALLENGES IN AN EXPERIENTIAL LEARNING FORMAT, STUDENTS WILL DEVELOP CRITICAL TECHNICAL AND LEADERSHIP SKILLS, AS WELL AS ENGAGE IN TEAMWORK AND PROBLEM-SOLVING ACTIVITIES. THROUGH DEEP MENTORSHIP FROM FACULTY AND APPLICATION OF THEORY TO PRACTICE, STUDENTS WILL GAIN REAL-WORLD LEADERSHIP EXPERIENCE IN SOLVING PROBLEMS AND DEVELOPING IDEAS TO SUPPORT AGRICULTURE-BASED ECONOMIC GROWTH AND COMMUNITY DEVELOPMENT. BUSINESSES GET THE SCIENCE AND SKILLS THEY NEED TO GROW, WHILE STUDENTS GAIN UNPARALLELED EXPERIENTIAL LEARNING AND LEADERSHIP EXPERIENCE, INCLUDING STRONG INCORPORATION OF SOCIAL SCIENCE KNOWLEDGE AND THEORY. THE PROJECT ALSO EMPHASIZES WORKFORCE DEVELOPMENT THROUGH PARTNERSHIP WITH LOCAL YOUTH ORGANIZATIONS AND TRAINING FOR INCUMBENT AND FUTURE WORKERS. DUE TO ITS EMPHASIS ON SCIENCE, EDUCATION AND SCIENCE LITERACY, AND RURAL PROSPERITY, THIS PROPOSAL ADDRESSES NLGCA PRIORITIES FROM THE USDA STRATEGIC PLAN (GOAL 1) REE ACTION PLAN (GOAL 6) , AND NIFA STRATEGIC PLAN (GOAL 1).IF FUNDED, THE PROJECT WILL PROVIDE SUPPORT FOR:RESEARCH AND EXPERIENTIAL LEARNING PROJECTS IN PARTNERSHIP WITH LOCAL BUSINESSES, FARMERS, AND COMMUNITY GROUPSUNDERGRADUATEAND GRADUATE STUDENT PROJECTS, PRESENTATIONS, AND TRAVELINFRASTRUCTURE/EQUIPMENT: ANALYTICAL INSTRUMENTATION, DRONES, SOFTWARE, UPDATED TECHNOLOGYSTUDENT MEDIA LAB/SCIENCE NEWS WIRE LAUNCHGRADUATE ASSISTANTS WORKING WITH THE UNIVERSITY OF ILLINOIS EXTENSION TO DELIVER AGRICULTURE EDUCATION PROGRAMMING IN REGIONAL MIDDLE AND HIGH SCHOOLSTRAVEL FUNDS FOR FIELD TRIPS, OUTREACH ACTIVITIES, AND OTHER JOINT AGRICULTURE EDUCATION OPPORTUNITIES FOR STUDENTS FROM MIDDLE SCHOOL TO GRADUATE SCHOOL

EARLY HEAD START ARRA EXPANSION

1/2 ADDRESSING RURAL CANCER HEALTH DISPARITIES: AN SCC-SIUSM PARTNERSHIP

CAREER: ELECTRON ACCEPTOR MATERIALS BASED ON CYCLOPENTA-FUSED POLYCYCLIC AROMATIC HYDROCARBONS

CHEMICAL LIBRARY SCREENING FOR POTENTIAL THERAPEUTICS USING NOVEL CELL-BASED MODELS OF ALS

FY 2020 EXPANDING CAPACITY FOR CORONAVIRUS TESTING (ECT)

MOLECULAR REGULATION AND ROLE OF PLACENTA GROWTH FACTOR

CAREER: DEVELOPMENT OF NOVEL BIOCATALYST FOR CONSOLIDATED BIOPROCESSING OF PLASTIC (CBPP) -OVER 20 MILLION TONS OF PLASTIC ENTERED THE ENVIRONMENT LAST YEAR. THIS REPRESENTS A LARGE AMOUNT OF CARBON THAT COULD OTHERWISE BE USED PRODUCTIVELY. IT ALSO REPRESENTS A LARGE SOURCE OF MICROPLASTICS, WHICH HARM HUMAN HEALTH. THIS PROJECT IS FOCUSED ON A NOVEL MICROORGANISM CAPABLE OF DECONSTRUCTING PLASTICS INTO ITS BASIC BUILDING BLOCKS, REFERRED TO AS MONOMERS. THESE MONOMERS COULD BE USED TO PRODUCE OTHER VALUABLE CHEMICALS. THE METABOLISM OF THE ORGANISMS WILL BE CHARACTERIZED. IT WILL THEN BE ENGINEERED TO PRODUCE SEVERAL VALUABLE CHEMICALS. TO TRAIN THE NEXT GENERATION WORKFORCE NEEDED TO COMBAT PLASTIC POLLUTION AND WORK IN FUTURE BIOINDUSTRIES, SEVERAL COURSES AND EDUCATIONAL OUTREACH PROGRAMS WILL BE DEVELOPED. MICROBES CAN DECONSTRUCT PLASTICS. THIS IS OFTEN A SLOW AND INCOMPLETE PROCESS. THIS IS DUE TO THE COMPACT MOLECULAR NATURE OF THE MATERIAL AND THE TOXIC INTERMEDIATES CREATED DURING DECONSTRUCTION. THIS PROJECT WILL INVESTIGATE A NOVEL ORGANISM, ERWINIA APHIDICOLA LJJL01, TO ELUCIDATE ITS CAPABILITIES THE DECONSTRUCTION AND CATABOLISM OF MIXED PLASTIC. THESE INCLUDE POLYETHYLENE TEREPHTHALATE (PET), POLYURETHANE (PU), POLYCARBONATE (PC). THIS BACTERIUM HAS BEEN ENGINEERED TO EFFICIENTLY BREAK DOWN PET INTO ITS ORIGINAL MONOMERS. IT SHOWS HIGH TOLERANCE TO PLASTIC-DERIVED COMPOUNDS A TIME-RESOLVED, MULTI-OMICS APPROACH WILL BE EMPLOYED TO IDENTIFY KEY FACTORS THAT INCREASE SECRETION OF PLASTIC DEGRADATION ENZYMES AND CHEMICAL TOXICITY TOLERANCE. THE OBJECTIVES ARE TWO-FOLD. DEVELOPING EFFICIENT MICROBIAL PROCESSES TO SELECTIVELY DECONSTRUCT MIXED PLASTIC WASTE UNDER MILD CONDITIONS IS THE FIRST. THE SECOND IS TO FUNNEL AND FUNCTIONALIZE PET, PU, AND PC DECONSTRUCTED COMPOUNDS TO SYNTHESIZE SEVERAL HIGH-VALUE MONOMERS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

SCHOOL CLIMATE ENHANCEMENT AND BULLYING PREVENTION IN SOUTHERN ILLINOIS

IDBR: DEVELOPMENT OF A NEW INSTRUMENT FOR DISCOVERING PROTEIN TARGETS

IUCRC PHASE I SOUTHERN ILLINOIS UNIVERSITY CARBONDALE: CENTER FOR INTELLIGENT, DISTRIBUTED, EMBEDDED, APPLICATIONS, AND SYSTEMS (IDEAS) -INTERNET OF THINGS DEVICES ? MORE THAN 43 BILLION IN USE ? MAKE OUR LIVES EASIER. TODAY?S DEVICES MOSTLY WATCH, COLLECT, AND TRANSMIT DATA TO BE ANALYZED ELSEWHERE. THE IDEAS CENTER WILL DRIVE CURRENT TECHNOLOGY TO ENABLE DEVICES TO ANALYZE THE DATA, LEARN FROM DATA, MAKE DECISIONS, AND ACT ON THOSE DECISIONS IN COORDINATION WITH OTHER DEVICES. THESE SMARTER DEVICES WILL REVOLUTIONIZE EVERY ASPECT OF LIFE: HEALTHCARE, INFRASTRUCTURE, AGRICULTURE, E-COMMERCE, TRANSPORTATION, MICROELECTRONICS, MANUFACTURING, ENTERTAINMENT, AEROSPACE, AND MANY MORE. IDEAS WILL COLLABORATE WITH COMPANIES IN ALL THESE INDUSTRIES TO IMPROVE THEIR BUSINESS PRACTICES AND PROVIDE THEM WITH EMPLOYEES TRAINED IN THESE TECHNOLOGIES. IDEAS? WORK, ?INTELLIGENT, DISTRIBUTED, EMBEDDED APPLICATIONS AND SYSTEMS,? ADDRESSES FUNDAMENTAL CHALLENGES AS THE PRESENT TWO-LAYER STRUCTURE OF THE INTERNET (USER-END DEVICES AT ONE END AND DATA CENTERS AT THE OTHER), EVOLVES INTO A MASSIVE, DISTRIBUTED NETWORK OF COMPUTERS THAT WILL PROVIDE COMPUTING AS A SERVICE. COMPANIES IN CRITICAL INDUSTRIES MUST EXPLOIT POSSIBLE EMERGING OPPORTUNITIES AS IOT, EDGE-CLOUD INFRASTRUCTURE, 5G COMMUNICATIONS, MICROELECTRONICS, AND INTELLIGENT COMPUTING CONVERGE. SIUC-IDEAS WILL FOCUS ON RELIABLE, POWER-EFFICIENT, AND ACCELERATED DEEP LEARNING ON DEVICES, DESIGN RELIABLE EMBEDDED SYSTEMS WITH TESTING AND VALIDATION CAPABILITIES, EDGE COMPUTING FOR INTELLIGENT EMBEDDED SYSTEMS, AND MODELING COMMUNICATIONS BETWEEN DISTRIBUTED SYSTEMS. IDEAS? TECHNOLOGIES WILL HELP MAKE ACCESS TO DATA, INFORMATION, AND DECISION-MAKING THROUGH COMPUTERS AS PERVASIVE AND COMMONPLACE AS ROADS, PUBLIC TRANSPORTATION, HOSPITALS, AND OTHER PUBLIC SERVICES THAT ARE PART AND PARCEL OF OUR DAILY LIVES. THE TECHNOLOGY WILL ALSO BE EXTREMELY ENERGY EFFICIENT SO THAT BUSINESSES CAN NOT ONLY RADICALLY IMPROVE THEIR OPERATING EFFICIENCY BUT ALSO MAKE THEIR ENTERPRISES MORE ENVIRONMENTALLY SUSTAINABLE. IDEAS WILL TRAIN FUTURE ENGINEERS AND SCIENTISTS FROM ALL SEGMENTS OF SOCIETY TO FURTHER ADVANCE THESE TECHNOLOGIES. COLLABORATIVE MENTORING WILL PROMOTE ENTREPRENEURIAL RESEARCH AMONG THE STUDENTS TO FOSTER THE NEXT GENERATION OF GROUND-BREAKING DISCOVERIES. IDEAS WILL BUILD AND MAINTAIN A SINGLE CENTER-WIDE DATA REPOSITORY. IT WILL BE MAINTAINED FOR IUCRC PHASE I AND FOR ANY SUBSEQUENT YEARS OF CENTER OPERATION. IT WILL BE DEVELOPED FOLLOWING IUCRC BEST PRACTICES FOR SECURING, DOCUMENTING, AND REPORTING DATA. WHILE INITIALLY, IT WILL BE CLOUD-BASED, WE WILL INTEGRATE ANY PHYSICAL INFRASTRUCTURE REQUIREMENTS SUCH AS SERVERS OR OTHER HARDWARE AS NEEDED. STRONG PASSWORD PROTECTION AND DUO-AUTHENTICATION PROPERTIES WILL BE INTEGRATED AS NEEDED. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

NURSE, EDUCATION, PRACTICE, QUALITY AND RETENTION - REGISTERED NURSES IN PRIMARY CARE

GREEN SCHOLARSHIPS: TRAINING FUTURE GENERATIONS OF ENVIRONMENTAL EXPERTS

CREATING EDUCATIONAL OPPORTUNITIES THROUGH PARTNERSHIPS

BEHAVIORAL HEALTH WORKFORCE EDUCATION AND TRAINING PROGRAM - TRAUMA-BASED BEHAVIORAL HEALTH FELLOWSHIP: HEALING-CENTERED INTEGRATED AND INTERDISCIPLINARY CARE TRAINING PROJECT AIMS TO EXPAND AND SUSTAIN THE TRAUMA-INFORMED BEHAVIORAL HEALTH WORKFORCE IN SOUTHERN ILLINOIS, A REGION CHARACTERIZED BY RURAL, MEDICALLY UNDERSERVED COMMUNITIES (MUCS), AND DESIGNATED BY HRSA AS A HEALTHCARE WORKFORCE SHORTAGE AREA. THIS COLLABORATIVE INITIATIVE SEEKS TO ADDRESS HEALTH DISPARITIES BY ENHANCING THE PROVISION OF TRAUMA-INFORMED, BILINGUAL MENTAL HEALTH SERVICES TO CHILDREN, ADOLESCENTS, AND TRANSITIONAL-AGED YOUTH IN BEHAVIORAL HEALTH (BH) AND INTEGRATED CARE (IC) SETTINGS. AT THE HEART OF THIS PROJECT IS THE WIDELY RECOGNIZED TRAUMA-BASED BEHAVIORAL HEALTH FELLOWSHIP (TBBHF) AT SOUTHERN ILLINOIS UNIVERSITY (SIU) SCHOOL OF MEDICINE (SOM). AN INTEGRATED/INTERPROFESSIONAL TRAINING PROGRAM THAT EQUIPS GRADUATE STUDENTS FOR CAREERS IN BH. THE PROGRAM FOCUSES ON TRAUMA-INFORMED SYSTEMS OF CARE, INTEGRATED HEALTH SYSTEMS, AND PREPARING STUDENTS TO WORK EFFECTIVELY IN INTERDISCIPLINARY TEAMS WITH VULNERABLE POPULATIONS, PARTICULARLY IN RURAL AND UNDERSERVED COMMUNITIES. THIS PROJECT IS FOCUSED ON CHILDREN, ADOLESCENTS AND YOUNG ADULTS. BUILDING ON THE PROGRAM'S 11 YEARS OF SUCCESS, THE CONTINUED FUNDING WILL STRENGTHEN THE HYBRID, INTERDISCIPLINARY DIDACTIC TRAINING CURRICULUM WITH A FOCUS ON HEALING-CENTERED INTEGRATED TRAUMA-INFORMED CARE, EVIDENCE-BASED TRAUMA INTERVENTIONS, TELEHEALTH, AND ENHANCED CLINICAL OFFERINGS FOR STUDENTS, FACULTY, AND FIELD SITE SUPERVISORS. KEY COMPONENTS OF THE CONTINUATION PROJECT INCLUDE: ENHANCED SUPERVISION FRAMEWORK: DEVELOPMENT OF A ROBUST SUPERVISION CURRICULUM FOR BOTH MSW STUDENTS AND CLINICAL SUPERVISORS; EDUCATIONAL SESSIONS FOR CLINICAL SUPERVISORS IN THE REGION TO ENSURE QUALITY PRACTICE IN COMMUNITY MENTAL HEALTH ORGANIZATIONS; POST-GRADUATION OPPORTUNITIES FOR CLINICAL SUPERVISION TO SUPPORT LICENSURE ATTAINMENT. PROFESSIONAL DEVELOPMENT: A PREPARATORY COURSE FOR STUDENTS TO OBTAIN LICENSURE; GUIDED INSTRUCTION FOR OBTAINING AN NPI NUMBER, A PROGRAM REQUIREMENT; CONTINUING EDUCATION IN INTERDISCIPLINARY AND IC TEAMS FOR FIELD SITE SUPERVISORS TO ENHANCE INTEGRATED SERVICE DELIVERY AND STREAMLINE PATIENT CARE. DIVERSE CLINICAL CASELOADS: USING VIRTUAL TRAINING TO EXPOSE STUDENTS TO DIVERSE CLIENTS, DIAGNOSES, CULTURAL BACKGROUNDS, AND COMPLEX, MULTIFACETED CASES; OPPORTUNITIES FOR STUDENTS TO DEVELOP CRITICAL THINKING AND DECISION-MAKING SKILLS THROUGH SIMULATED AND REAL-WORLD SCENARIOS. ENHANCED SUPPORT FOR EXPERIENTIAL SITES: TARGETED TRAINING AND RESOURCES TO ASSIST EXPERIENTIAL SITES IN ADOPTING IC SYSTEMS AND PROVIDING STREAMLINED, PATIENT-CENTERED SERVICES. THIS PROJECT WILL RECRUIT A DIVERSE GROUP OF 48 STUDENTS OVER THE 4-YEAR GRANT PERIOD, FROM THE MSW PROGRAM AT SOUTHERN ILLINOIS UNIVERSITY CARBONDALE. EACH STUDENT WILL BE ASSIGNED A MENTOR/SITE SUPERVISOR AT ONE OF THE 7 INTEGRATED/INTERDISCIPLINARY SITES. ONCE ACCEPTED, THE MSW FELLOWS WILL ATTEND A DIDACTIC TRAINING EVERY FRIDAY FOR 4 HOURS OVER TWO SEMESTERS. THE HEALING-CENTERED INTEGRATED INTERDISCIPLINARY CURRICULUM IS BUILT ORGANICALLY WITH THE LATEST RESEARCH IN TRAUMA INFORMED EVIDENCE BASED CLINICAL PRACTICES. TO FORTIFY THE MSW TFS PROFESSIONAL GROWTH AND CLINICAL SUCCESS, A HEALING-CENTERED INTEGRATED INTERDISCIPLINARY CLINICAL SUPERVISION TRAINING. WITH ADDITIONAL GROUP CONSULTATION. WILL BE A RESOURCE FOR THE SITE SUPERVISORS, WHO WILL MEET QUARTERLY FOR CONSULTATION. ADDITIONAL PROFESSIONAL DEVELOPMENT ENHANCEMENT FOR GRADUATING STUDENTS INCLUDE A LICENSING PREP COURSE AND CONNECTION TO EMPLOYMENT OPPORTUNITIES IN THE MEDICAL UNDERSERVED REGION OF SOUTHERN ILLINOIS. THIS WILL INCREASE THE SUPPLY OF A DIVERSE BH WORKFORCE WHO ARE TRAINED TO PROVIDE INTEGRATED CARE IN RURAL SOUTHERN ILLINOIS WHICH AIMS TO IMPROVE PATIENT CARE AND HEALTH EQUITY. THIS PROJECT MEETS THE QUALIFICATIONS FOR A FUNDING PRIORITY AND PREFERENCE. (ATTACHMENT 8)

EXAMINING FACULTY ATTITUDES AND STRATEGIES THAT SUPPORT SUCCESSFUL FLIPPED TEACHING

LEADERSHIP DEVELOPMENT PROGRAM IN ENGINEERING AND TECHNOLOGY

DESC: TYPE I: TOWARDS GREENER AI COMPUTING: DESIGNING AND MANAGING SUSTAINABLE HETEROGENEOUS EDGE DATA CENTERS -ARTIFICIAL INTELLIGENCE (AI) HAS RECENTLY EMERGED AS A PROMINENT FIELD OF RESEARCH IN COMPUTING, WITH ENORMOUS POTENTIAL TO POSITIVELY INFLUENCE SOCIETY AND IT IS PROJECTED TO GROW CONSIDERABLY IN THE COMING YEARS. THE AI MARKET IS ANTICIPATED TO EXPAND TENFOLD INTO A SECTOR WORTH HUNDREDS OF BILLIONS OF DOLLARS WITHIN THE NEXT FIVE YEARS. HOWEVER, THE RAPID EXPANSION OF AI TECHNOLOGIES HAS RESULTED IN CONSIDERABLE ENVIRONMENTAL IMPACT AND RAISED CONCERNS ABOUT THEIR ASSOCIATED OPERATIONAL AND EMBODIED CARBON FOOTPRINTS. THE FORMER IS ASSOCIATED WITH THEIR ONGOING OPERATION AND MAINTENANCE WHILE THE LATTER WITH THE ENTIRE LIFE CYCLE OF THE DEVICES. THIS PROJECT AIMS TO SUBSTANTIALLY IMPROVE THE SUSTAINABILITY OF MODERN EDGE DATA CENTERS BY MITIGATING THE ENVIRONMENTAL IMPACT OF AI AND BOOSTING THE EFFICIENCY OF DATA PROCESSING. IT WILL ADVANCE BEYOND AI, TOWARDS THE DEVELOPMENT OF SUSTAINABLE EDGE DATA CENTERS. IT WILL ALSO PROMOTE THE ADOPTION OF SUSTAINABLE PRACTICES IN THE COMPUTING INDUSTRY AS A WHOLE. AS A RESULT, IT WILL CONTRIBUTE TO A BROADER PARADIGM SHIFT TOWARDS EMBRACING MORE ECO-FRIENDLY PRACTICES IN THE COMPUTING DOMAIN AND IT WILL STRENGTHEN EFFORTS IN DRIVING THE DIGITAL INFRASTRUCTURE?S TRANSITION TOWARDS A GREENER AND MORE SUSTAINABLE FUTURE. THE CENTRAL AIM OF THIS PROJECT IS TO IMPROVE THE SUSTAINABILITY OF EDGE DATA CENTERS USED FOR AI COMPUTING THROUGH EXTENSIVE, MULTI-LAYERED OPTIMIZATIONS. UNLIKE CONVENTIONAL CENTRALIZED DATA CENTERS, EDGE DATA CENTERS ARE DESIGNED TO BE CLOSER TO END-USERS AND CAN HARNESS RENEWABLE ENERGY FOR THEIR OPERATIONS. THIS MINIMIZES THE NEED FOR EXTENSIVE DATA TRANSMISSION AND ENABLES A MORE LOCALIZED COMPUTING INFRASTRUCTURE. THIS PROJECT MOVES BEYOND TRADITIONAL OPTIMIZATION METHODS AND TARGETS VERTICAL SOLUTIONS AS MULTIPLE PARAMETERS AFFECT OPERATIONAL AND EMBODIED CARBON FOOTPRINTS. MORE SPECIFICALLY, THE OPERATIONAL CARBON FOOTPRINT CAN BE LESSENED BY HARNESSING RENEWABLE ENERGY SOURCES, ENHANCING POWER USAGE EFFICIENCY, AND STRATEGICALLY DISTRIBUTING WORKLOAD ACROSS VARIOUS COMPUTING COMPONENTS. ON THE OTHER HAND, THE EMBODIED CARBON FOOTPRINT CAN BE DECREASED BY DOWNSCALING ENERGY-EFFICIENT HARDWARE ACCELERATORS, IMPLEMENTING LOW-FOOTPRINT CIRCUIT DESIGNS, AND ENHANCING SYSTEM RELIABILITY TO EXTEND ITS LIFESPAN. TO COVER ALL THESE ASPECTS, THIS PROJECT WILL FOLLOW A CARBON-FIRST VERTICAL APPROACH THAT WILL INITIALLY DEVELOP ROBUST CIRCUIT-LEVEL AND ARCHITECTURAL-LEVEL HARDWARE ACCELERATORS FOR EDGE DATA CENTERS, THEN WILL IMPROVE THE SYSTEM?S UTILIZATION, AND WILL EVENTUALLY EFFICIENTLY MANAGE EDGE DATA CENTERS AT THE RUN-TIME LEVEL WITH RENEWABLE ENERGY SOURCES. OVERALL, THE DEVELOPMENT OF RELIABLE HARDWARE ACCELERATORS AND EFFICIENT UTILIZATION OF COMPUTING RESOURCES WILL LEAD TO MORE ENERGY-EFFICIENT DATA CENTERS, BY REDUCING THEIR CARBON FOOTPRINT AND IMPROVING THEIR OVERALL SUSTAINABILITY. FURTHERMORE, INTEGRATING RENEWABLE ENERGY SOURCES IN THE MANAGEMENT OF EDGE DATA CENTERS WILL PROMOTE THE USE OF CLEAN ENERGY AND REDUCE RELIANCE ON NON-RENEWABLE SOURCES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

CAREER: PROGRAMMABLE ACTIVE LITHOGRAPHY USING NANOTUBE ARRAYS

MRI-R2: ACQUISITION OF RAMAN AND INFRARED MICROSCOPES FOR INTERDISCIPLINARY RESEARCH

TAS::57 3600::TAS UNDERSTANDING LASER-CLUSTER INTERACTIONS IN THE X-RAY REGIME

SIUE OVW STUDENT AFFAIRS 2016

LOW-COST, HIGH-THROUGHPUT 3D PULMONARY IMAGING USING HYPERPOLARIZED PROPANE GAS

CODING IN AUDITORY NEURONS: EFFECTS OF AMINO ACIDS - PROJECT SUMMARY AGE-RELATED HEARING LOSS (ARHL) IS A COMPLEX DISORDER AFFECTING BETWEEN 50-70% OF THE UNITED STATES POPULATION AGED 65 OR OLDER. IN PUBLIC SETTINGS, SENIORS FREQUENTLY HAVE GREAT DIFFICULTY UNDERSTANDING SPEECH, WHICH CAN LEAD TO WITHDRAWAL FROM SOCIAL ACTIVITIES, DEPRESSION AND COGNITIVE DECLINE. ALL INDIVIDUALS AND ESPECIALLY THE ELDERLY CAN MAINTAIN SPEECH UNDERSTANDING IN DIFFICULT LISTENING CONDITIONS BY ENGAGING ATTENTIONAL, COGNITIVE AND MNEMONIC (TOP-DOWN) RESOURCES TO HELP DISAMBIGUATE SPEECH FROM A DEGRADED ASCENDING ACOUSTIC CODE. UNDERSTANDING THE IMPACT OF AGING ON CIRCUITS THAT MAINTAIN SPEECH UNDERSTANDING AND THE PHARMACOLOGY OF CHOLINERGIC ATTENTIONAL SYSTEMS IN THEIR MODULATION IS AT THE CORE OF THE PROPOSED STUDIES. STUDIES DURING THE PREVIOUS GRANT PERIOD IDENTIFIED DIFFERENTIAL AGE-RELATED CHANGES IN NICOTINIC CHOLINERGIC RECEPTOR (NACHR) SUBUNIT/SUBTYPES IN THE MEDIAL GENICULATE BODY (MGB) AND PRIMARY AUDITORY CORTEX (AI). IN VITRO AGING STUDIES DETAILED THE PRE- AND POSTSYNAPTIC FUNCTION OF NACHRS IN THALAMIC CIRCUITS LIKELY TO UNDERPIN ATTENTIONAL MODULATION OF ACOUSTIC INFORMATION. UNIT RECORDINGS FROM AWAKE RAT AUDITORY THALAMUS MGB ALSO SHOWED AGE-RELATED REPETITION-ENHANCEMENT, AS OPPOSED TO SENSORY ADAPTATION, IN RESPONSE TO REPEATING/PREDICTABLE TEMPORALLY RICH STIMULI. THIS WAS POSITED TO REFLECT INCREASED USE OF CORTICOFUGAL/HIGHER- ORDER RESOURCES. AGE-RELATED ENHANCED CODING OF REPEATING MODULATED STIMULI WAS REPRODUCED IN YOUNG ANIMALS BY SIMPLY DEGRADING THE TEMPORAL CLARITY OF THE SINUSOIDAL AMPLITUDE MODULATED (SAM) STIMULI. CORTICOTHALAMIC BLOCKADE OF PROJECTIONS TO MGB REVERSED PREDICTIVE REPETITION-ENHANCEMENT TO A DEGREE, BUT NOT COMPLETELY. THE PROPOSED SPECIFIC AIMS WILL ADDRESS QUESTIONS RAISED BY THESE PRIOR STUDIES AND SUPPORTED BY PRELIMINARY DATA. IN VITRO AND IN VIVO APPROACHES IN RATS WILL: SA1: CHARACTERIZE THE FUNCTIONAL PHARMACOLOGY AND THE IMPACT OF AGING ON NACHR PHARMACOLOGY IN THE CENTRAL AND DORSAL NUCLEI OF THE INFERIOR COLLICULUS (CNIC, ENIC AND DNIC). SA2A: DETERMINE SINGLE UNIT RESPONSE PROPERTIES OF CNIC AND DNIC UNITS TO TEMPORALLY DISTINCT AND LESS TEMPORALLY DISTINCT SAM STIMULI PRESENTED IN REPEATING/PREDICTABLE OR RANDOM SEQUENCES. SA2B: DETERMINE THE IMPACT OF AGING ON THE RESPONSE PROPERTIES OF CNIC AND DNIC UNITS TO REPEATING VS. RANDOMLY PRESENTED SAM STIMULI. SA3. DETERMINE THE IMPACT OF PONTINE MESENCEPHALIC TEGMENTUM (PMT) RELEASE OF ACETYLCHOLINE ON THE RESPONSE PROPERTIES OF IC UNITS TO TEMPORALLY DISTINCT AND TEMPORALLY LESS DISTINCT SAM STIMULI PRESENTED IN A REPEATING OR RANDOM SEQUENCES. UNDERSTANDING THE MECHANISMS INVOLVED IN REPETITION ENHANCEMENT/PREDICTIVE CODING AND IDENTIFICATION OF NOVEL NACHR SUBTYPES POTENTIALLY RESISTANT TO AGING WILL INFORM FUTURE BEHAVIORAL AND PHARMACOTHERAPEUTIC APPROACHES TO IMPROVE SPEECH UNDERSTANDING IN THE ELDERLY.

CAREER: DESIGN, OPTIMIZATION, AND FEEDBACK CONTROL OF NONCONTACT MAGNETIC MANIPULATORS

CIRCUIT-LEVEL COMPUTATIONS OF SOCIAL OPPORTUNITY COSTS UNDER FORAGING CONSTRAINTS - PROJECT SUMMARY ANIMALS ROUTINELY FACE THE CHALLENGE OF DECIDING WHEN TO REMAIN WITH A VALUABLE SOCIAL PARTNER VERSUS SEEKING RESOURCES THAT SATISFY IMMEDIATE PHYSIOLOGICAL NEEDS, YET EXISTING THEORIES TREAT THESE DECISION DOMAINS IN ISOLATION. WE HYPOTHESIZE THAT A SHARED TEMPORAL CURRENCY, COMPUTED BY INTERCONNECTED PREFRONTAL AND AMYGDALAR CIRCUITS, ENABLES MOMENT-TO-MOMENT ARBITRATION BETWEEN SOCIAL OPPORTUNITY AND HOMEOSTATIC DRIVE. OUR LONG- TERM GOAL IS TO ESTABLISH SOCIAL DECISION-MAKING WITHIN A FORAGING CONTEXT, ENABLING THE EXAMINATION OF ITS UNDERLYING NEURAL AND GENETIC MECHANISMS. OUR OBJECTIVE IS TO REVEAL HOW THE HIERARCHICAL ORGANIZATION OF THE PREFRONTAL–AMYGDALA CIRCUIT MAPS ONTO THE HIERARCHICALLY STRUCTURED DYNAMICS OF SOCIAL FORAGING DECISIONS. TO ACHIEVE THESE GOAL WE WILL LEVERAGE A UNIQUELY NATURALISTIC SOCIAL--FORAGING PARADIGM—WHERE MICE SHUTTLE BETWEEN A SOCIAL PATCH AND A WATER PATCH WHILE ENCOUNTERING VARIABLE TRAVEL COSTS AND A MANIPULABLE HISTORY OF PARTNER ENCOUNTERS—WE WILL: AIM 1 QUANTIFY AND MODEL THE DECISION RULES THAT GOVERN SOCIAL– HYDRATION TRADE-OFFS; AIM 2 CAUSALLY MAP THE UNDERLYING COMPUTATIONS WITH CLOSED-LOOP, COMPUTATION-CONTINGENT OPTOGENETICS. THIS STUDY WILL CLOSE A FUNDAMENTAL GAP BY PROVIDING THE FIRST INTEGRATED, EXPERIMENTALLY VALIDATED FRAMEWORK THAT UNIFIES ECOLOGICAL THEORY, COMPUTATION, AND CIRCUIT MECHANISMS OF ADAPTIVE SOCIAL DECISION-MAKING.

ALDO-KETO REDUCTASE I B10 AS A NOVEL TARGET FOR BREAST CANCER TREATMENT