Michigan State University

FACILITY FOR RARE ISOTOPE BEAMS

OPERATION OF THE FACILITY FOR RARE ISOTOPE BEAMS AS SCIENTIFIC USER FACILITY

OPERATION OF THE NSCL AS A NATIONAL USER FACILTY & RESEARCH PROGRAM

OPERATION OF THE NSCL AS A NATIONAL USER FACILTY & RESEARCH PROGRAM

OPERATION OF THE NATIONAL SUPERCONDUCTING CYCLOTRON LABORATORY AT MICHIGAN STATE UNIVERSITY AS A NATIONAL USER FACILITY & SUPPORT FOR ITS RESEARCH PR

CARES ACT FUNDING REQUEST FOR MICHIGAN STATE UNIVERSITY - INSTITUTION PORTION (COVID-19)

CARES ACT FUNDING REQUEST FOR MICHIGAN STATE UNIVERSITY (COVID-19)

HIGH RIGIDITY SPECTROMETER PROJECT

INTERDISCIPLINARY RESEARCH AND RELATED TRAINING PROGRAM IN THE PLANT SCIENCES

BEACON: AN NSF CENTER FOR THE STUDY OF EVOLUTION IN ACTION

ENVIRONMENTAL, MICROBIAL, AND MAMMALIAN BIOMOLECULAR RE*

NEW DRY GRAIN PULSES CRSP. FIVE-YEAR AWARD WITH TEC OF $9,000,000. THIS IS AN LWA.

INTERDISCIPLINARY RESEARCH PROGRAM IN THE FUNDAMENTAL PLANT SCIENCES

HIGHER EDUCATION SOLUTIONS NETWORK

FEED THE FUTURE INNOVATION LAB FOR FOOD SECURITY POLICY

FEED THE FUTURE INNOVATION LAB FOR LEGUMES SYSTEMS RESEARCH

PRENATAL EXPOSURES AND CHILD HEALTH OUTCOMES: A STATEWIDE STUDY

DETERMINANTS OF MALARIA DISEASE IN MALAWI

THE GREAT LAKES MIDWEST REGIONAL FOOD BUSINESS CENTER (GLM-RFBC), SERVING MICHIGAN, WISCONSIN, ILLINOIS, AND INDIANA WITH REGIONAL TRIBAL, SUPPORT SEEKS INVESTMENT FOR NETWORK DEVELOPMENT AND A COORDINATED FOOD AND FARM BUSINESS SUPPORT SYSTEM FOR THOSE W

FLINT LEAD EXPOSURE REGISTRY (FLEXR)

FLINT REGISTRY (FR) 2022-2027 - THIS PROPOSAL AIMS TO CONTINUE SUPPORTING THE FLINT REGISTRY (FR), A DESIGNATED PUBLIC HEALTH AUTHORITY THAT IS ADDRESSING THE PUBLIC HEALTH EMERGENCY CREATED WHEN ~100,000 RESIDENTS OF FLINT, MICHIGAN, WERE EXPOSED TO LEAD IN DRINKING WATER FROM 4/25/2014 TO 10/15/2015 (KNOWN AS THE FLINT WATER CRISIS). THE FR ADDRESSES THE CRITICAL NEED TO IDENTIFY EXPOSED INDIVIDUALS FOR LONG-TERM SURVEILLANCE AND SUPPORT, AND TO DETERMINE THE NEURODEVELOPMENTAL, MEDICAL, AND SOCIOECONOMIC IMPACT OF THE CRISIS. WITH WIDESPREAD COMMUNITY PARTNERSHIP, THE FR HAS BUILT A FULLY OPERATIONAL PUBLIC HEALTH INFRASTRUCTURE THAT HAS ENROLLED ALMOST 20,000 INDIVIDUALS AND MADE MORE THAN 25,000 CONNECTIONS TO PUBLIC HEALTH PROMOTING RESOURCES. BY CONNECTING PARTICIPANTS TO A COMMUNITY NETWORK OF SERVICE PROVIDERS WITH PROGRAMS DESIGNED TO IMPROVE HEALTH AND DEVELOPMENT, AS WELL AS BY REDUCING ONGOING LEAD EXPOSURES, THE FR IS ALREADY REDUCING HEALTH DISPARITIES. THE FR CONTINUES TO ADDRESS THE ONGOING PUBLIC HEALTH IMPACT OF THE WATER CRISIS BY MAINTAINING THE FR COHORT FOR LONG-TERM SURVEILLANCE AND PARTICIPANT SUPPORT AND BY CONTINUING TO RECRUIT AND ENROLL ADDITIONAL ELIGIBLE PARTICIPANTS. LEVERAGING THE FR'S CURRENTLY BUILT INFRASTRUCTURE, WE WILL MAINTAIN AND EXPAND THE FR TO ACCOMPLISH THE FOLLOWING AIMS: 1) CONTINUE ACTIVE AND TARGETED MARKETING AND OUTREACH, WITH ONGOING LEAD ELIMINATION TRAINING AND PROGRAMMING; 2) IDENTIFY AND RECRUIT HIGH-RISK INDIVIDUALS; 3) SURVEY THOSE ENROLLED IN THE REGISTRY TO MEASURE REGISTRANTS' EXPOSURE, HEALTH, DEVELOPMENTAL MILESTONES, AND SERVICE UTILIZATION AND REFER REGISTRANTS TO SERVICES TO REDUCE OR CONTROL LEAD EXPOSURE EFFECT; 4) MAINTAIN, SURVEY, AND REFER COHORT OF ENROLLED PARTICIPANTS; AND 5) EVALUATE AND DISSEMINATE FINDINGS AND SHARE BEST PRACTICES.

FEED THE FUTURE INNOVATION LAB FOR FOOD SECURITY POLICY, RESEARCH, CAPACITY, AND INFLUENCE (IL-FSPRCI)

REVOLUTIONARY MATERIALS FOR SOLID STATE ENERGY CONVERSION: A DOE ENERGY FRONTIER RESEARCH CENTER -- EFRC

TRANSFORMING HIGHER EDUCATION SYSTEMS ACTIVITY IN MALAWI

JINA CENTER FOR THE EVOLUTION OF THE ELEMENTS

NEUROHUMORAL CONTROL OF VEINS IN HYPERTENSION

ENHANCED PROGRAM IN OCCUPATIONAL INJURY AND ILLNESS SURVEILLANCE

PERIVASCULAR ADIPOSE TISSUE (PVAT) AS A CENTRAL INTEGRATOR OF VASCULAR HEALTH - SUMMARY - OVERALL VASCULAR HEALTH IS ESSENTIAL TO THE NORMAL REGULATION OF CARDIOVASCULAR FUNCTION. THAT DYSFUNCTIONS OF BLOOD PRESSURE REGULATION, SUCH AS HYPERTENSION, REMAIN DIFFICULT TO TREAT SUGGESTS THAT THE SCIENTIFIC COMMUNITY DOES NOT FULLY UNDERSTAND THE MECHANISMS BY WHICH NORMAL AND PATHOLOGICAL CHANGES IN BLOOD PRESSURE ARE ACHIEVED, NOR HOW THE VASCULATURE CAN BOTH INFLUENCE AND BE IMPACTED BY CHANGES IN BLOOD PRESSURE. THIS NEW PROGRAM PROJECT GRANT IS BASED ON THE OVERALL HYPOTHESIS THAT PERIVASCULAR ADIPOSE TISSUE (PVAT) HAS BIDIRECTIONAL INTERACTIONS WITH THE OTHER LAYERS OF A BLOOD VESSEL AND IS A CRITICAL PARTNER WITH THESE LAYERS TO FORM AN INTEGRATED SYSTEM THAT MAINTAINS VASCULAR HEALTH. OUR COLLECTIVE PRELIMINARY WORK HAS LED TO THE HYPOTHESIS THAT PVAT AND ITS PRIMARY COMPONENTS – THE ADIPOCYTE AND PROGENITOR CELLS, THE IMMUNE CELLS, AND NEURONAL INNERVATION/NEUROHUMORAL CONTROL —ARE CENTRAL INTEGRATORS OF OVERALL VASCULAR HEALTH/FUNCTION. THIS GRANT WILL ENABLE FOUNDATIONAL STUDIES THAT ARE CRITICAL TO UNDERSTANDING HOW THE ELEMENTS OF PVAT WORK TOGETHER, AND ULTIMATELY INFLUENCE VASCULAR TONE. THIS GRANT IS UNIQUE IN THAT IT WILL ALSO INTERROGATE HOW (PATHO)PHYSIOLOGICAL CHALLENGES (E.G. CHANGE IN STRETCH, PRESSURE) PLACED ON A VESSEL AFFECT PVAT FUNCTION. OUR STUDIES WILL PROGRESS TO A MODEL OF HIGH FAT (HF)-DIET INDUCED HYPERTENSION, A SITUATION OF ELEVATED VASCULAR PRESSURE AND PVAT BURDEN. THIS WORK WILL USE MODELS THAT ALLOW FOR THE MOST RIGOROUS EXPERIMENTATION: MICE IN NERVE- AND ADIPOCYTE PROGENITOR LINEAGE-TRACING; OPTOGENETIC AND CHEMOGENETIC APPROACHES; RATS AS A MODEL ORGANISM FOR HF-DIET INDUCED HYPERTENSION; PRESSURE IMPOSITION THROUGH A NOVEL MID-THORACIC AORTIC COARCTED MODEL; NOVEL MICROSCOPIC AND BIOINFORMATIC WORK; AND HUMAN VASCULATURE + PVAT FOR TRANSLATIONAL POTENTIAL. OUR COLLECTIVE, NOVEL APPROACH CONTRASTS DIRECTLY WITH THE PLETHORA OF LITERATURE THAT INVESTIGATES HOW THE PVAT SECRETOME INFLUENCES VASCULAR FUNCTION. WE WILL DETERMINE, THROUGH PROJECTS SUPPORTED BY FOUR CORES (ADMINISTRATIVE, ANIMAL, BIOINFORMATIC AND MICROSCOPY), WHETHER: 1) PVAT POSSESSES THE ABILITY TO MECHANOTRANSDUCE AND HAS SIGNIFICANT STIFFNESS THAT CONTRIBUTES TO VASCULAR STIFFNESS; 2) PVAT IS INNERVATED OR UNDER NEUROHUMORAL CONTROL WITH FUNCTIONAL CONSEQUENCE; 3) WHETHER THE UNIQUE MICROENVIRONMENT OF PVAT INFLUENCES IMMUNE CELL FUNCTION; AND 4) HOW THE FATE OF ADIPOCYTE PROGENITORS IS INFLUENCED BY VASCULAR STRETCH. INVESTIGATORS ARE DEEPLY INVESTED IN THE PLANNING OF, EXECUTION OF AND LEARNING FROM EXPERIMENTS CARRIED OUT IN PROJECTS AND CORES OTHER THAN THEIRS; THIS WORK WAS PURPOSEFULLY DEVELOPED IN THIS WAY TO BE SYNERGISTIC. THIS INTEGRATED WORK ADVANCES HUMAN HEALTH BY REDEFINING THE FUNCTIONAL VESSEL, A REDEFINITION THAT COULD HAVE SIGNIFICANT IMPACT ON NOT ONLY HYPERTENSION BUT ALL PHYSIOLOGIES AND DYSFUNCTIONS WHICH INVOLVE THE VASCULATURE.

NAFSP

PRENATAL EXPOSURES AND CHILD HEALTH OUTCOMES: A STATEWIDE STUDY

THE NATIONAL CENTER FOR HEALTH AND JUSTICE INTEGRATION FOR SUICIDE PREVENTION - JUSTICE-INVOLVED INDIVIDUALS HAVE HIGH RATES OF TRAIT, STATE, AND PRECIPITATING RISK FACTORS FOR SUICIDE, ACCOUNT FOR A SIGNIFICANT PROPORTION OF U.S. SUICIDES EACH YEAR, AND MANY ARE NOT WELL-CONNECTED TO CARE. THE NATIONAL CENTER FOR HEALTH AND JUSTICE INTEGRATION FOR SUICIDE PREVENTION (NCHATS): (1) USES CONTACT WITH THE JUSTICE SYSTEM (E.G., POLICE CONTACT, ARREST) AS A NOVEL INDICATOR OF SUICIDE RISK IN THE GENERAL POPULATION; (2) DEMONSTRATES HOW BIG DATA SYSTEMS THAT EFFICIENTLY TRACK JUSTICE INVOLVEMENT CAN BE LINKED TO HEALTH SYSTEM RECORDS AND SCALED TO IDENTIFY INDIVIDUALS AT RISK FOR SUICIDE AND CONNECT THEM TO CARE; AND (3) EXAMINES EFFECTIVENESS AND SCALABILITY OF SUICIDE PREVENTION APPROACHES USING THESE METHODS. CENTER PROJECTS ARE HYBRID EFFECTIVENESS-IMPLEMENTATION STUDIES THAT EXAMINE EFFECTIVENESS, COST-EFFECTIVENESS, AND SCALABILITY OF SUICIDE PREVENTION ACTIVITIES TRIGGERED THROUGH LINKAGE OF JUSTICE AND HEALTH DATA. GIVEN THAT CONTACT WITH THE JUSTICE SYSTEM IS A SIGN OF RISK FOR SUICIDE, BIG DATA INTEGRATION ACROSS JUSTICE/HEALTH SYSTEMS TO FLAG MOVEMENT BETWEEN SYSTEMS (AND THEREFORE SUICIDE RISK) PROVIDES A NOVEL METHOD OF IDENTIFYING SUICIDE RISK IN THE GENERAL POPULATION. THIS APPROACH DOES NOT REQUIRE COLLECTING NEW DATA FROM THIS HARD-TO-REACH POPULATION. RATHER, IT SETS UP STRATEGIES TO EFFICIENTLY LINK EXISTING DATA AND TO TEST METHODS TO RESPOND. THIS IS AN INNOVATIVE AND POTENTIALLY SCALABLE APPROACH TO IDENTIFY/ADDRESS SUICIDE RISK FOR INDIVIDUALS NOT WELL-CONNECTED WITH STANDARD HEALTH CARE. THE CENTER IS INNOVATIVE IN THAT IT: (1) ESTABLISHES A SUICIDE PREVENTION INTERVENTION EFFECTIVENESS BASE FOR A LARGE AND HIGH-RISK TARGET POPULATION, CONDUCTING (A) 2 OF ONLY 3 FULLY-POWERED SUICIDE PREVENTION RCTS IN JUSTICE POPULATIONS, AND (B) THE LARGEST RCTS OF ANY INTERVENTION FOR ANY CONDITION IN A JUSTICE-INVOLVED POPULATION TO DATE; (2) DEVELOPS AND MANUALIZES STRATEGIES FOR SCALABILITY AND SUSTAINMENT -- UNDERSTUDIED AREAS OF IMPLEMENTATION SCIENCE; (3) USES CONTACT WITH THE JUSTICE SYSTEM AS A NOVEL INDICATOR OF SUICIDE RISK IN THE GENERAL POPULATION; (4) USES SOCIOMETRIC IDENTIFICATION OF KEY INDIVIDUALS TO PROMOTE DIFFUSION AND DISSEMINATION OF CENTER APPROACHES; (5) DEMONSTRATES HOW EFFICIENT, GENERALIZABLE HEALTH AND JUSTICE SYSTEM BIG DATA LINKAGE IS ACHIEVED AND CAN BE USED TO AUTOMATE SUICIDE RISK IDENTIFICATION AND RESPONSE ACROSS HEALTH AND JUSTICE SYSTEMS AT SCALE. THIS IS EXTREMELY RARELY DONE IN PRACTICE AND NEVER BEFORE TESTED AS A METHOD OF IMPROVING HEALTH OUTCOMES IN JUSTICE POPULATIONS. BY INCORPORATING THE FEW CASES OF WHICH WE ARE AWARE INTO THIS CENTER, WE ARE POISED TO RAPIDLY ADVANCE THE FIELD. CENTER AIMS ARE TO: (1) EVALUATE EFFECTIVENESS AND COST-EFFECTIVENESS OF SUICIDE PREVENTION APPROACHES THAT USE JUSTICE CONTACTS AS MARKERS OF RISK AND HEALTH/JUSTICE SYSTEM DATA LINKAGE TO PROVIDE SCALABLE WAYS TO ALERT PROVIDERS OF THIS RISK; (2) MAXIMIZE SCALABILITY, SUSTAINABILITY, RELEVANCE, AND DISSEMINATION OF IDENTIFIED APPROACHES AND IDENTIFY, REFINE, AND MANUALIZE SCALABILITY/SUSTAINMENT STRATEGIES TO BE FULLY TESTED IN FUTURE TRIALS; AND (3) PROMOTE NATIONAL RESEARCH AND PRACTICE CAPACITY IN SUICIDE PREVENTION AT JUSTICE INTERCEPTS. PARTNERS INCLUDE JAILS, POLICE, HEALTH PLANS, HEALTHCARE SYSTEMS, COURTS, JUDGES, COMMUNITY CORRECTIONS, RACIAL EQUITY, AND LIVED EXPERIENCE.

THIS ACTIVITY WILL ENGAGE IN AFRICA (ETHIOPIA AND NIGERIA) AND SOUTHEAST ASIA (BANGLADESH AND INDONESIA) TO ADVANCE BLIGHT-RESISTANT POTATO VARIETIES THROUGH THE PRODUCT LIFE CYCLE. THE ACTIVITY WILL ALSO IMPROVE THE CAPACITY OF PARTNER-COUNTRY RESEARCHERS AND MARKET SYSTEMS TO DEVELOP AND DISSEMINATE BIOTECHNOLOGY PRODUCTS THAT ADDRESS FOOD SECURITY CHALLENGES -¿ ULTIMATELY ENHANCING THE PRODUCTIVITY, RESILIENCE, AND NUTRITION OF SMALLHOLDERS.

TO SUPPORT THE DEVELOPMENT AND SUSTAINABILITY OF A NEW ZAMBIAN AGRICULTURAL POLICY RESEARCH AND OUTREACH INSTITUTION AS WELL AS TO BUILD CAPACITY FO

THE FLINT CENTER FOR HEALTH EQUITY SOLUTIONS

PROJECT PURPOSETHE MOON-LIGHT PROJECT COMBINES MIDDLE MILE FIBER BROADBAND EXPANSION WITH ENGAGEMENT OF LAST MILE BROADBAND PROVIDERS IN THE STATE OF MICHIGAN. IN THE 74 COUNTIES WHERE MERIT/MOON-LIGHT WOULD HAVE A PRESENCE, MOON-LIGHT WOULD ENABLE A TOTAL OF 103 ACCESS POINTS WITH ALMOST 70,000 CENSUS BLOCKS AND OVER 120,000 UNSERVED LOCATIONS.MERIT HAS SECURED LETTERS OF INTENT FROM THREE LAST-MILE SERVICE PROVIDERS WHICH HAVE BEEN PROVIDED. MOON-LIGHT WILL ENABLE BROADBAND SERVICE IN THEIR TERRITORIES TO AT LEAST 16,499 UNSERVED HOUSEHOLDS. MERIT IDENTIFIED ONLY THOSE HOUSEHOLDS INDICATED BY FCC 477 DATA, WHICH ARE BY DEFINITION FULLY UNSERVED WITHIN PER PROVIDER COUNTS.ACTIVITIESTHE PROJECT INTENDS TO EXPAND THE OPTICAL CAPABILITIES OF MERIT'S EXISTING 2,200-MILE PHYSICAL FIBER NETWORK. MOON-LIGHT WOULD FUTURE-PROOF THIS ESTABLISHED FOUNDATION TO EXPAND THE OPTICAL CAPABILITIES OF MERIT'S EXISTING FIBER NETWORK BY ADJUSTING THE SIZING AND CAPACITY OF THE OPTICAL NETWORK TO REDUCE POWER AND COLLOCATION REQUIREMENTS AND REPLACE AGING MULTI-SLOT TERMINAL TECHNOLOGIES WITH MODERN DATA CENTER INTERCONNECT TECHNOLOGIES CAPABLE OF SUPPORTING BOTH NEW AND EXISTING SERVICES FROM 10 GBPS TO 800 GBPS CAPACITIES EITHER NATIVELY OR THROUGH AGGREGATION ONTO THE COHERENT CORE ARCHITECTURE. THE PROPOSED MOON-LIGHT ARCHITECTURE WILL CONSIST OF ROADMS OFFERING ALTERNATE ADD/DROP APPROACHES AND OPTICAL AMPLIFIERS OF DIFFERENT TYPES OPTIMIZED FOR SPECIFIC NETWORK REQUIREMENTS. IN THIS PROJECT, MOON-LIGHT WILL DRASTICALLY EXPAND ACCESS TO LAST-MILE PROVIDERS SEEKING TO DELIVER SERVICE TO UNSERVED COMMUNITIES.OUTCOMESMERIT'S EXISTING FIBER INFRASTRUCTURE CURRENTLY RUNS THROUGH ALL COUNTIES IN MI EXCEPT 9. IN THE 74 COUNTIES WHERE MERIT/MOON-LIGHT WOULD HAVE A PRESENCE, MOON-LIGHT WOULD ENABLE A TOTAL OF 103 ACCESS POINTS WITH ALMOST 70,000 CENSUS BLOCKS AND OVER 120,000 UNSERVED LOCATIONS. MERIT HAS SECURED LETTERS OF INTENT FROM THREE LAST-MILE SERVICE PROVIDERS. MOON-LIGHT WILL ENABLE BROADBAND SERVICE IN THEIR TERRITORIES TO AT LEAST 16,499 UNSERVED HOUSEHOLDS. UPON COMPLETION, MOON-LIGHT COULD BE LEVERAGED BY LAST-MILE PROVIDERS TO SERVE THOUSANDS OF UNSERVED LOCATIONS IN MICHIGAN AT LEAST 2,305 OF THESE BEING UNSERVED RURAL HOUSEHOLDS. MOON-LIGHT'S ENABLEMENT OF ACCESSIBLE, AFFORDABLE TRANSPORT SERVICES WILL ENHANCE THE VIABILITY OF LAST-MILE DEPLOYMENT PROJECT NOT ONLY AT THE 100/20 PERFORMANCE LEVEL BUT ALSO AT MUCH HIGHER PERFORMANCE LEVELS AND WILL SCALE EASILY ALONG WITH THE HIGH-CAPACITY DEMAND OF GIGABIT-TIER LAST MILE NETWORKS, SUCH AS FTTP (FIBER-TO-THE-PREMISE), AND THEREFORE WILL TEND TO SUPPORT OR SOLIDIFY PLANS FOR EXPANDED OR NEW LAST-MILE NETWORKS WITH THAT PERFORMANCE LEVEL.BENEFICIARIESTHIS IS A STATEWIDE PROJECT DESIGNED TO SERVE 16,499 CURRENTLY UNSERVED HOUSEHOLDS ACROSS MICHIGAN. THE PROJECT WILL ALSO ENABLE ALL OF MERIT'S EXISTING COMMUNITY MEMBERS, PUBLIC SECTOR, NONPROFIT AND PRIVATE ORGANIZATIONS, GOVERNMENTAL AGENCIES, EDUCATIONAL INSTITUTIONS, AND REGIONAL BROADBAND SERVICE PROVIDERS WITH EXPANDED AND ECONOMICAL ACCESS TO LAYER 3 COMMODITY INTERNET SERVICES, PEERING OPPORTUNITIES, AND CLOUD SERVICE PROVIDER ACCESS BY LEVERAGING NEW DARK WAVELENGTH TRANSPORT SERVICES. MERIT'S EXISTING ACCESSIBLE, AFFORDABLE MIDDLE MILE NETWORK LACKS THE CONNECTION AND TRAFFIC CAPACITY TO SERVE EXPANDED OR NEW LAST-MILE NETWORKS. MOON-LIGHT WILL SOLVE THIS PROBLEM AND ALLOW MERIT TO MAKE ITS OPEN-ACCESS NETWORK BROADLY AVAILABLE IN SUPPORT OF CURRENTLY PLANNED AND FUTURE LAST-MILE NETWORKS IN NOW-UNSERVED RURAL AREAS, SUCH AS THE UPPER PENINSULA AND CRAWFORD COUNTY.SUBRECIPIENT ACTIVITIESMERIT NETWORK, INC. IS A SUBRECIPIENT OF FEDERAL FUNDS FOR THIS PROJECT. MERIT'S SCOPE OF WORK INCLUDES NETWORK PLANNING AND IMPLEMENTATION, THIRD PARTY CONTRACTOR MANAGEMENT SOURCING, FEDERAL COMPLIANCE, ENABLING MIDDLE-MILE OPEN ACCESS, ENGAGEMENT, AND ASSISTING WITH REPORTING AND AUDIT REQUIREMENTS.

A SYSTEMS APPROACH TO INCREASING CARBON FLUX TO SEED OIL FOR BIOFUELS AND BIOPRODUCTS PRODUCTION IN CAMELINA SATIVA

** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** RECENT MULTIPLE SHOCKS (E.G., COVID-19 COMBINED WITH CLIMATE SHOCKS AND FOODBORNE PATHOGENS) HAVE REVEALED CRITICAL VULNERABILITIES OF AGRI-FOOD SYSTEMS. THESE SHOCKS UNIQUELY CHALLENGE LOCAL AND REGIONAL FOOD SUPPLY CHAINS, MANY OF WHICH PRODUCE, PROCESS, AND DISTRIBUTE FOOD PRODUCTS CRITICAL TO THE FOOD AND NUTRITIONAL SECURITY OF THE US POPULATION. THE GOAL OF THIS PROJECT IS TO BUILD LOCAL AND REGIONAL FOOD SYSTEMS THAT ARE RESILIENT TO MULTIPLE SHOCKS. THIS GOAL WILL BE ACCOMPLISHED THROUGH NINE INTERRELATED OBJECTIVES. OBJECTIVES 1-3 EVALUATE KEY CHARACTERISTICS OF SUPPLY CHAINS, IMPACTS OF HISTORICAL AND PROJECTED SHOCKS, AND ALTERNATIVE MITIGATION/ADAPTATION STRATEGIES. OBJECTIVES 4-5 CENTER ON INNOVATIVE SYSTEMS MODELING, SIMULATION, AND DECISION SUPPORT USING ARTIFICIAL INTELLIGENCE. OBJECTIVE 6 EXAMINES THE IMPACT OF SHOCKS AND MITIGATION STRATEGIES ON FOOD AND NUTRITION SECURITY, PARTICULARLY AMONG VULNERABLE US POPULATIONS. OBJECTIVES 7-8 APPLY NOVEL RESEARCH FINDINGS TO EXTENSION AND EDUCATION. OBJECTIVE 9 PROMOTES A HOLISTIC INTEGRATION OF RESEARCH, EXTENSION, AND EDUCATION TO INSPIRE FUTURISTIC, EQUITABLE SOLUTIONS TO POLICYMAKERS AND STAKEHOLDERS. THE PROJECT WILL RESULT IN FUNDAMENTAL INSIGHTS AND KNOWLEDGE SURROUNDING THE EFFECTS OF MULTIPLE SHOCKS ON LOCAL AND REGIONAL FOOD SYSTEMS AS WELL AS A SUITE OF MITIGATION STRATEGIES AND DECISION-MAKING, EXTENSION, AND EDUCATIONAL TOOLS. THESE RESULTS WILL FILL CRITICAL KNOWLEDGE GAPS IN OUR UNDERSTANDING OF HOW TO BUILD MORE RESILIENT LOCAL AND REGIONAL FOOD SYSTEMS, EMPOWER STAKEHOLDERS (ESPECIALLY DISADVANTAGED AND VULNERABLE COMMUNITIES) TO MITIGATE AND ADAPT TO MULTIPLE SHOCKS, AND DEVELOP A NEW AND DIVERSE WORKFORCE THAT SUPPORTS AGRI-FOOD RESILIENCE. ULTIMATELY, THE PROJECT WILL LEAD TO MORE RESILIENT AND SUSTAINABLE AGRI-FOOD SYSTEMS THAT IMPROVE FOOD AND NUTRITIONAL SECURITY, PROSPERITY, AND WELL-BEING IN THE MIDWEST U.S. AND BEYOND.

SCALING A PROJECT-BASED CURRICULUM THAT USES MULTIPLE LITERACIES TO TRANSFORM SCIENCE LEARNING IN ELEMENTARY SCHOOLS IN THE DEEP SOUTH

PROJECT ABSTRACT - MICHIGAN STATE UNIVERSITY: JOINT COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND? GRANT INSTITUTIONS AND UNIVERSITY OF THE DISTRICT OF COLUMBIA PUBLIC POSTSECONDARY EDUCATION REORGANIZATION ACT PROGRAM DEPARTMENT OF AGRICULTURE NATIONAL INSTITUTE OF FOOD AND AGRICULTURE MICHIGAN STATE UNIVERSITY EXTENSION HELPS IMPROVE PEOPLE'S LIVES THROUGH AN EDUCATIONAL PROCESS THAT APPLIES KNOWLEDGE TO CRITICAL ISSUES, NEEDS, AND OPPORTUNITIES. FOR MORE THAN 100 YEARS, MSU EXTENSION FACULTY AND STAFF MEMBERS HAVE BEEN ACTIVELY REACHING PEOPLE WHERE THEY ARE - IN THEIR HOMES, FARMS, BUSINESSES, AND COMMUNITIES - WITH RESEARCH DRIVEN EDUCATION. WE HELP PEOPLE PERFORM THEIR JOBS BETTER, RAISE HEALTHY AND SAFE FAMILIES, BUILD STRONGER COMMUNITIES, AND EMPOWER CHILDREN TO DREAM OF BRIGHTER FUTURES. WITH SMITH?LEVER FUNDING, MSU EXTENSION FOSTERS ECONOMIC DEVELOPMENT, IMPROVED QUALITY OF LIFE, A HEALTHY ENVIRONMENT, AND A PLENTIFUL AND SECURE FOOD SUPPLY FOR MICHIGAN RESIDENTS. PROMOTINGWELL?BEING FOR MICHIGAN'S YOUTH AND FAMILIES REQUIRES ATTENDING TO INDIVIDUALS' PHYSICAL, SOCIAL?EMOTIONAL, AND BEHAVIORAL HEALTH. TO IMPROVE THE HEALTH AND SAFETY OF MICHIGAN'S ADULTS, YOUTH, AND FAMILIES, WE DEVELOPED BROAD AND COMPREHENSIVE RESEARCH AND EDUCATION PROGRAMS TO ADDRESS MICHIGAN RESIDENTS' NEEDS. YOUTH DEVELOPMENT, COMMUNITY DEVELOPMENT, NUTRITION AND FOOD SAFETY RESEARCH AND EDUCATION, AND FAMILY AND PARENTING SKILLS ARE IMPORTANT AREAS OF FOCUS. WE WILL SUPPORT MICHIGAN RESIDENTS IN EATING HEALTHIER, BEING BETTER CAREGIVERS, AND PREVENTING AND MANAGING CHRONIC HEALTH CONDITIONS THROUGH EDUCATION; DEVELOP BETTER MODELS FOR THE HUMAN HEALTH AND HUMAN SERVICES SECTORS; STUDY THE FUNCTION OF NUTRIENTS AND OTHER COMPONENTS RELATED TO HUMAN HEALTH; IMPROVE MANAGEMENT OF FINANCIAL RESOURCES BY INDIVIDUALS AND FAMILIES THROUGH EDUCATION; PREPARE YOUTH FOR LIFE AND WORK. SUCCESSFUL AND THRIVING COMMUNITIES COMBINE KNOWLEDGEABLE AND ENGAGED LEGISLATORS, BUSINESSES, COMMUNITY GROUPS, AND RESIDENTS. AGRICULTURAL PRODUCERS BENEFIT FROM IMPROVING THEIR BUSINESS AND FINANCIAL MANAGEMENT SKILLS, WHETHER THEY RAISE DAIRY COWS OR GROW BLUEBERRIES. MARKETING, DISTRIBUTION AND OTHER ECONOMIC VARIABLES ALSO PLAY A CRITICAL ROLE IN THE SUCCESS AND PROFITABILITY OF THE STATE'S AGRICULTURE AND NATURAL RESOURCES INDUSTRIES. WE WILL ASSIST ENTREPRENEURS WHO DEVELOP AND COMMERCIALIZE HIGH?VALUE, CONSUMER?RESPON SIVE PRODUCTS AND BUSINESSES; RESEARCH AND PROVIDE EDUCATION ON INTERNATIONAL TRADE AND DEVELOPMENT, ECONOMIC POLICY, DOMESTIC AND FOREIGN POLICY, AND COMMUNITY RESOURCE PLANNING AND DEVELOPMENT TO HELP MICHIGAN GROWERS AND PRODUCERS NAVIGATE GOVERNMENTAL REGULATIONS BOTH HERE AND ABROAD, AS WELL AS CONNECT THEM WITH FOREIGN BUYERS AND MARKETS; ASSIST MICHIGAN COMMUNITIES IN MAKING CRITICAL POLICY DECISIONS AND FUNCTIONING MORE SMOOTHLY WITH CITIZEN INVOLVEMENT.

PROJECT ABSTRACT - MICHIGAN STATE UNIVERSITY: JOINT COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND-GRANT INSTITUTIONS AND UNIVERSITY OF THE DISTRICT OF COLUMBIA PUBLIC POSTSECONDARY EDUCATION REORGANIZATION ACT PROGRAM DEPARTMENT OF AGRICULTURE NATIONAL INSTITUTE OF FOOD AND AGRICULTURE MICHIGAN STATE UNIVERSITY EXTENSION HELPS IMPROVE PEOPLE'S LIVES THROUGH AN EDUCATIONAL PROCESS THAT APPLIES KNOWLEDGE TO CRITICAL ISSUES, NEEDS, AND OPPORTUNITIES. FOR MORE THAN 100 YEARS, MSU EXTENSION FACULTY AND STAFF MEMBERS HAVE BEEN ACTIVELY REACHING PEOPLE WHERE THEY ARE - IN THEIR HOMES, FARMS, BUSINESSES, AND COMMUNITIES - WITH RESEARCH DRIVEN EDUCATION. WE HELP PEOPLE PERFORM THEIR JOBS BETTER, RAISE HEALTHY AND SAFE FAMILIES, BUILD STRONGER COMMUNITIES, AND EMPOWER CHILDREN TO DREAM OF BRIGHTER FUTURES. WITH SMITH-LEVER FUNDING, MSU EXTENSION FOSTERS ECONOMIC DEVELOPMENT, IMPROVED QUALITY OF LIFE, A HEALTHY ENVIRONMENT, AND A PLENTIFUL AND SECURE FOOD SUPPLY FOR MICHIGAN RESIDENTS. PROMOTING WELL-BEING FOR MICHIGAN'S YOUTH AND FAMILIES REQUIRES ATTENDING TO INDIVIDUALS' PHYSICAL, SOCIAL-EMOTIONAL, AND BEHAVIORAL HEALTH. TO IMPROVE THE HEALTH AND SAFETY OF MICHIGAN'S ADULTS , YOUTH, AND FAMILIES, WE DEVELOPED BROAD AND COMPREHENSIVE RESEARCH AND EDUCATION PROGRAMS TO ADDRESS MICHIGAN RESIDENTS' NEEDS. YOUTH DEVELOPMENT, COMMUNITY DEVELOPMENT, NUTRITION AND FOOD SAFETY RESEARCH AND EDUCATION, AND FAMILY AND PARENTING SKILLS ARE IMPORTANT AREAS OF FOCUS. WE WILL SUPPORT MICHIGAN RESIDENTS IN EATING HEALTHIER, BEING BETTER CAREGIVERS, AND PREVENTING AND MANAGING CHRONIC HEALTH CONDITIONS THROUGH EDUCATION; DEVELOP BETTER MODELS FOR THE HUMAN HEALTH AND HUMAN SERVICES SECTORS; STUDY THE FUNCTION OF NUTRIENTS AND OTHER COMPONENTS RELATED TO HUMAN HEALTH; IMPROVE MANAGEMENT OF FINANCIAL RESOURCES BY INDIVIDUALS AND FAMILIES THROUGH EDUCATION; PREPARE YOUTH FOR LIFE AND WORK. SUCCESSFUL AND THRIVING COMMUNITIES COMBINE KNOWLEDGEABLE AND ENGAGED LEGISLATORS, BUSINESSES, COMMUNITY GROUPS, AND RESIDENTS. AGRICULTURAL PRODUCERS BENEFIT FROM IMPROVING THEIR BUSINESS AND FINANCIAL MANAGEMENT SKILLS, WHETHER THEY RAISE DAIRY COWS OR GROW BLUEBERRIES. MARKETING, DISTRIBUTION AND OTHER ECONOMIC VARIABLES ALSO PLAY A CRITICAL ROLE IN THE SUCCESS AND PROFITABILITY OF THE STATE'S AGRICULTURE AND NATURAL RESOURCES INDUSTRIES. WE WILL ASSIST ENTREPRENEURS WHO DEVELOP AND COMMERCIALIZE HIGH-VALUE, CONSUMER-RESPONSIVE PRODUCTS AND BUSINESSES; RESEARCH AND PROVIDE EDUCATION ON INTERNATIONAL TRADE AND DEVELOPMENT, ECONOMIC POLICY, DOMESTIC AND FOREIGN POLICY, AND COMMUNITY RESOURCE PLANNING AND DEVELOPMENT TO HELP MICHIGAN GROWERS AND PRODUCERS NAVIGATE GOVERNMENTAL REGULATIONS BOTH HERE AND ABROAD, AS WELL AS CONNECT THEM WITH FOREIGN BUYERS AND MARKETS; ASSIST MICHIGAN COMMUNITIES IN MAKING CRITICAL POLICY DECISIONS AND FUNCTIONING MORE SMOOTHLY WITH CITIZEN INVOLVEMENT.

PROJECT ABSTRACT - MICHIGAN STATE UNIVERSITY: JOINT COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND GRANT INSTITUTIONS AND UNIVERSITY OF THE DISTRICT OF COLUMBIA PUBLIC POSTSECONDARY EDUCATION REORGANIZATION ACT PROGRAM DEPARTMENT OF AGRICULTURE NATIONAL INSTITUTE OF FOOD AND AGRICULTURE - MICHIGAN STATE UNIVERSITY EXTENSION HELPS IMPROVE PEOPLE'S LIVES THROUGH AN EDUCATIONAL PROCESS THAT APPLIES KNOWLEDGE TO CRITICAL ISSUES, NEEDS, AND OPPORTUNITIES. FOR MORE THAN 100 YEARS, MSU EXTENSION FACULTY AND STAFF MEMBERS HAVE BEEN ACTIVELY REACHING PEOPLE WHERE THEY ARE - IN THEIR HOMES, FARMS, BUSINESSES, AND COMMUNITIES - WITH RESEARCH DRIVEN EDUCATION. WE HELP PEOPLE PERFORM THEIR JOBS BETTER, RAISE HEALTHY AND SAFE FAMILIES, BUILD STRONGER COMMUNITIES, AND EMPOWER CHILDREN TO DREAM OF BRIGHTER FUTURES. WITH SMITH-LEVER FUNDING, MSU EXTENSION FOSTERS ECONOMIC DEVELOPMENT, IMPROVED QUALITY OF LIFE, A HEALTHY ENVIRONMENT, AND A PLENTIFUL AND SECURE FOOD SUPPLY FOR MICHIGAN RESIDENTS. PROMOTING WELL-BEING FOR MICHIGAN'S YOUTH AND FAMILIES REQUIRES ATTENDING TO INDIVIDUALS' PHYSICAL, SOCIAL-EMOTIONAL, AND BEHAVIORAL HEALTH. TO IMPROVE THE HEALTH AND SAFETY OF MICHIGAN'S ADULTS, YOUTH, AND FAMILIES, WE DEVELOPED BROAD AND COMPREHENSIVE RESEARCH AND EDUCATION PROGRAMS TO ADDRESS MICHIGAN RESIDENTS' NEEDS. YOUTH DEVELOPMENT, COMMUNITY DEVELOPMENT, NUTRITION AND FOOD SAFETY RESEARCH AND EDUCATION, AND FAMILY AND PARENTING SKILLS ARE IMPORTANT AREAS OF FOCUS. WE WILL SUPPORT MICHIGAN RESIDENTS IN EATING HEALTHIER, BEING BETTER CAREGIVERS, AND PREVENTING AND MANAGING CHRONIC HEALTH CONDITIONS THROUGH EDUCATION; DEVELOP BETTER MODELS FOR THE HUMAN HEALTH AND HUMAN SERVICES SECTORS; STUDY THE FUNCTION OF NUTRIENTS AND OTHER COMPONENTS RELATED TO HUMAN HEALTH; IMPROVE MANAGEMENT OF FINANCIAL RESOURCES BY INDIVIDUALS AND FAMILIES THROUGH EDUCATION; PREPARE YOUTH FOR LIFE AND WORK. SUCCESSFUL AND THRIVING COMMUNITIES COMBINE KNOWLEDGEABLE AND ENGAGED LEGISLATORS, BUSINESSES, COMMUNITY GROUPS, AND RESIDENTS. AGRICULTURAL PRODUCERS BENEFIT FROM IMPROVING THEIR BUSINESS AND FINANCIAL MANAGEMENT SKILLS, WHETHER THEY RAISE DAIRY COWS OR GROW BLUEBERRIES. MARKETING, DISTRIBUTION AND OTHER ECONOMIC VARIABLES ALSO PLAY A CRITICAL ROLE IN THE SUCCESS AND PROFITABILITY OF THE STATE'S AGRICULTURE AND NATURAL RESOURCES INDUSTRIES. WE WILL ASSIST ENTREPRENEURS WHO DEVELOP AND COMMERCIALIZE HIGH-VALUE, CONSUMER-RESPONSIVE PRODUCTS AND BUSINESSES; RESEARCH AND PROVIDE EDUCATION ON INTERNATIONAL TRADE AND DEVELOPMENT, ECONOMIC POLICY, DOMESTIC AND FOREIGN POLICY, AND COMMUNITY RESOURCE PLANNING AND DEVELOPMENT TO HELP MICHIGAN GROWERS AND PRODUCERS NAVIGATE GOVERNMENTAL REGULATIONS BOTH HERE AND ABROAD, AS WELL AS CONNECT THEM WITH FOREIGN BUYERS AND MARKETS; ASSIST MICHIGAN COMMUNITIES IN MAKING CRITICAL POLICY DECISIONS AND FUNCTIONING MORE SMOOTHLY WITH CITIZEN INVOLVEMENT.

MICHIGAN STATE UNIVERSITY EXTENSION HELPS IMPROVE PEOPLE'S LIVES THROUGH AN EDUCATIONAL PROCESS THAT APPLIES KNOWLEDGE TO CRITICAL ISSUES, NEEDS, AND OPPORTUNITIES. FOR MORE THAN 100 YEARS, MSU EXTENSION FACULTY AND STAFF MEMBERS HAVE BEEN ACTIVELY REACHING PEOPLE WHERE THEY ARE - IN THEIR HOMES, FARMS, BUSINESSES, AND COMMUNITIES - WITH RESEARCH DRIVEN EDUCATION. WE HELP PEOPLE PERFORM THEIR JOBS BETTER, RAISE HEALTHY AND SAFE FAMILIES, BUILD STRONGER COMMUNITIES, AND EMPOWER CHILDREN TO DREAM OF BRIGHTER FUTURES. WITH SMITH-LEVER FUNDING, MSU EXTENSION FOSTERS ECONOMIC DEVELOPMENT, IMPROVED QUALITY OF LIFE, A HEALTHY ENVIRONMENT, AND A PLENTIFUL AND SECURE FOOD SUPPLY FOR MICHIGAN RESIDENTS. PROMOTING WELL-BEING FOR MICHIGAN'S YOUTH AND FAMILIES REQUIRES ATTENDING TO INDIVIDUALS' PHYSICAL, SOCIAL-EMOTIONAL, AND BEHAVIORAL HEALTH. TO IMPROVE THE HEALTH AND SAFETY OF MICHIGAN'S ADULTS, YOUTH, AND FAMILIES, WE DEVELOPED BROAD AND COMPREHENSIVE RESEARCH AND EDUCATION PROGRAMS TO ADDRESS MICHIGAN RESIDENTS' NEEDS. YOUTH DEVELOPMENT, COMMUNITY DEVELOPMENT, NUTRITION AND FOOD SAFETY RESEARCH AND EDUCATION, AND FAMILY AND PARENTING SKILLS ARE IMPORTANT AREAS OF FOCUS. WE WILL SUPPORT MICHIGAN RESIDENTS IN EATING HEALTHIER, BEING BETTER CAREGIVERS, AND PREVENTING AND MANAGING CHRONIC HEALTH CONDITIONS THROUGH EDUCATION; DEVELOP BETTER MODELS FOR THE HUMAN HEALTH AND HUMAN SERVICES SECTORS; STUDY THE FUNCTION OF NUTRIENTS AND OTHER COMPONENTS RELATED TO HUMAN HEALTH; IMPROVE MANAGEMENT OF FINANCIAL RESOURCES BY INDIVIDUALS AND FAMILIES THROUGH EDUCATION; PREPARE YOUTH FOR LIFE AND WORK. SUCCESSFUL AND THRIVING COMMUNITIES COMBINE KNOWLEDGEABLE AND ENGAGED LEGISLATORS, BUSINESSES, COMMUNITY GROUPS, AND RESIDENTS. AGRICULTURAL PRODUCERS BENEFIT FROM IMPROVING THEIR BUSINESS AND FINANCIAL MANAGEMENT SKILLS, WHETHER THEY RAISE DAIRY COWS OR GROW BLUEBERRIES. MARKETING, DISTRIBUTION AND OTHER ECONOMIC VARIABLES ALSO PLAY A CRITICAL ROLE IN THE SUCCESS AND PROFITABILITY OF THE STATE'S AGRICULTURE AND NATURAL RESOURCES INDUSTRIES. WE WILL ASSIST ENTREPRENEURS WHO DEVELOP AND COMMERCIALIZE HIGH-VALUE, CONSUMER-RESPONSIVE PRODUCTS AND BUSINESSES; RESEARCH AND PROVIDE EDUCATION ON INTERNATIONAL TRADE AND DEVELOPMENT, ECONOMIC POLICY, DOMESTIC AND FOREIGN POLICY, AND COMMUNITY RESOURCE PLANNING AND DEVELOPMENT TO HELP MICHIGAN GROWERS AND PRODUCERS NAVIGATE GOVERNMENTAL REGULATIONS BOTH HERE AND ABROAD, AS WELL AS CONNECT THEM WITH FOREIGN BUYERS AND MARKETS; ASSIST MICHIGAN COMMUNITIES IN MAKING CRITICAL POLICY DECISIONS AND FUNCTIONING MORE SMOOTHLY WITH CITIZEN INVOLVEMENT.

MICHIGAN STATE UNIVERSITY FEDERAL FISCAL YEAR 2022 SMITH LEVER EXTENSIONPROGRAMS

**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** PATHOGENIC BACTERIA IN LOW-MOISTURE FOODS IS A SIGNIFICANT AND INCREASING PROBLEM, IN TERMS OF BOTH PUBLIC HEALTH AND ECONOMIC IMPACTS ON THE U.S. FOOD SYSTEM. SALMONELLA HAS BEEN LINKED TO NATIONWIDE OUTBREAKS AND RECALLS INVOLVING A BROAD RANGE OF PRODUCTS, INCLUDING ALMONDS, BLACK PEPPER, HAZELNUTS, PEANUT PRODUCTS, PISTACHIOS, PET FOOD, SOY PRODUCTS, AND BREAKFAST CEREAL. ADDITIONALLY, PATHOGENIC ESCHERICHIA COLI AND LISTERIA MONOCYTOGENES ARE INCREASINGLY IMPLICATED IN OUTBREAKS AND/OR RECALLS LINKED TO LOW-MOISTURE FOODS, INCLUDING NUT PRODUCTS AND WHEAT FLOUR. A SINGLE SALMONELLOSIS OUTBREAK LINKED TO PEANUT PRODUCTS COST THE INDUSTRY ~$1 BILLION, AND OUR ESTIMATE OF THE ASSOCIATED HEALTH BURDEN WAS ~$200 MILLION. OVERALL, LOW-MOISTURE FOOD RECALLS IN THE LAST DECADE CAUSED ~5% MEAN LOSS IN MARKET CAPITALIZATION FOR AFFECTED PUBLIC COMPANIES, AVERAGING >$400 MILLION LOST PER RECALL EVENT. SMALL OR MEDIUM-SIZED COMPANIES GENERALLY ARE UNABLE TO SURVIVE SUCH EVENTS, RESULTING IN BANKRUPTCY AND/OR CLOSURE. ADDITIONALLY, ONGOING IMPLEMENTATION OF WHOLE-GENOME SEQUENCING IN OUTBREAK INVESTIGATIONS BY THE CDC WILL INCREASE THE NUMBER OF OUTBREAKS DETECTED. HOWEVER, THE ROOT CAUSES OF THESE FAILURES (SCIENTIFIC, TECHNICAL, AND/OR HUMAN) OFTEN ARE UNIDENTIFIED. FURTHERMORE, MUCH OF THE LOW-MOISTURE FOOD INDUSTRY IS COMPRISED OF HISTORICAL/LEGACY SYSTEMS, SUCH AS HARVESTERS, DRYERS, MILLS, AND OVENS, THAT WERE DESIGNED TO ACHIEVE ECONOMIC GOALS, BUT NOT NECESSARILY FOOD SAFETY OUTCOMES. THIS IS A LARGE, BUT UNSOLVED FARM-TO-CONSUMER PROBLEM. THEREFORE, THERE IS A SIGNIFICANT NEED FOR A TRANSDISCIPLINARY, SYSTEMS-BASED APPROACH TO BETTER PROTECT U.S. PUBLIC HEALTH AND SUSTAINABILITY OF INDUSTRY OPERATIONS. IN OUR APPROACH TO THIS PROBLEM, OUR SYSTEM IS DEFINED AS HARVEST-TO-CONSUMPTION FOR LOW-MOISTURE FOODS. IN SUSTAINABILITY TERMS, THIS PROJECT ADDRESSES WORKFORCE TRAINING AND PUBLIC HEALTH IMPACTS (PEOPLE), ENERGY USE AND ENVIRONMENTAL IMPACTS OF PATHOGEN CONTROL SOLUTIONS (PLANET), AND RISK-INFORMED COST-BENEFIT ANALYSES OF CHANGES IN THE LOW-MOISTURE FOOD SYSTEM (PROFIT).THEREFORE, THE OVERALL GOAL OF THIS PROJECT IS TO ACCELERATE THE ADOPTION OF A SUSTAINABLE FOOD SAFETY CULTURE IN COMMODITY-BASED LOW-MOISTURE FOOD SYSTEMS (VIA AN INTEGRATED, TRANSDISCIPLINARY, SYSTEMS-BASED APPROACH, WITH INTERCONNECTED AND PARALLEL RESEARCH, EXTENSION, AND EDUCATION ACTIVITIES). RESEARCH, OUTREACH, AND EDUCATION ACTIVITIES WILL BE HIGHLY INTEGRATED, OUTCOMES-FOCUSED, AND STAKEHOLDER-ENGAGED (INCLUDING A STAKEHOLDER ADVISORY GROUP AND A DIVERSITY, EQUITY, AND INCLUSION ADVISORY TEAM), AND SUBJECT TO SYSTEMATIC ASSESSMENT. RESEARCH AND OUTREACH ACTIVITIES WILL ENCOMPASS RISK, ECONOMIC, AND SUSTAINABILITY ANALYSES, FOOD SAFETY CULTURE ASSESSMENTS, PATHOGEN CONTROL SOLUTIONS, AND MULTIPLE WORKSHOPS, WEBINARS, AND RESOURCES SUPPORTING SYSTEMS-BASED FOOD SAFETY IMPROVEMENTS. EDUCATION ACTIVITIES WILL ENTAIL NOVEL COURSE AND CONTENT DEVELOPMENT FOR BOTH ASSOCIAT,E- (WORKER) AND GRADUATE-LEVEL (SCIENTIFIC/TECHNICAL) LEARNING. OVERALL, THIS PROJECT WILL REDUCE FOODBORNE ILLNESSES, AND ASSOCIATED RECALLS, LINKED TO LOW-MOISTURE FOODS, THEREBY IMPROVING THE PROTECTION OF PUBLIC HEALTH AND SUSTAINABILITY OF INDUSTRY OPERATIONS OF ALL SCALES.

MICHIGAN STATE UNIVERSITY'S FY-19 SMITH-LEVER EXTENSION PROGRAMS

MICHIGAN STATE UNIVERSITY'S FY-20 SMITH-LEVER EXTENSION PROGRAMS

MICHIGAN STATE UNIVERSITY FY-21 SMITH-LEVER EXTENSION PROGRAMS

A NEXT GENERATION RECOIL SEPARATOR FOR NUCLEAR ASTROPHYSICS SECAR (SEPARATOR FOR CAPTURE REACTIONS)

MICHIGAN STATE UNIVERSITY'S FY-17 SMITH-LEVER EXTENSION PROGAMS

MICHIGAN STATE UNIVERSITY'S FY-18 SMITH-LEVER EXTENSION PROGRAMS

MICHIGAN STATE UNIVERSITY EXTENSION SMITH-LEVER PROGRAMS FOR FFY-14

TREATING BRAIN SWELLING IN PEDIATRIC CEREBRAL MALARIA

ACCELERATE ADOPTION OF MORE EFFECTIVE POLICIES AND PROGRAMS TO DRIVE BROAD-BASED AGRICULTURAL SECTOR GROWTH, IMPROVED HOUSEHOLD FOOD SECURITY AND NUTRITION, AND REDUCED POVERTY IN TANZANIA.

MSUE PROGRAMS, FFY-12

CDC-RFA-IP21-2113

BII: LIFE WITHOUT WATER: PROTECTING MACROMOLECULES, CELLS, AND ORGANISMS DURING DESICCATION AND REHYDRATION ACROSS KINGDOMS OF LIFE -LIFE ON EARTH EVOLVED IN THE OCEANS AND CONSEQUENTLY ALL LIFE ON OUR PLANET IS COMPOSED MOSTLY OF WATER. WHEN LIFE MOVED OUT OF THE OCEAN, SURVIVING ENVIRONMENTS WITH LIMITED WATER BECAME A NECESSITY. ONE APPROACH TO SURVIVE THIS NEW EXTREME, THAT IS PRESENT ACROSS ALL KINGDOMS OF LIFE, IS TO DRY OUT, OR DESICCATE, WHILE WAITING FOR WATER TO RETURN. TOLERATING DESICCATION REQUIRES COORDINATION ACROSS CELLS, TISSUES, AND ORGANISMS, BUT THE DETAILS OF HOW THIS HAPPENS ARE UNKNOWN. THE WATER AND LIFE INTERFACE INSTITUTE (WALII) BIOLOGY INTEGRATION INSTITUTE WILL FILL IN THESE GAPS USING FUNGI, PLANTS, AND ANIMALS WITH LOW AND HIGH DESICCATION TOLERANCE. THE LONG-TERM GOALS OF THIS INSTITUTE ARE UNDERSTANDING HOW ORGANISMS TOLERATE DESICCATION, INVENTING TECHNOLOGIES, AND CONCEPTS FOR WORKING IN LOW-WATER ENVIRONMENTS, ENGINEERING PROTEINS, CELLS, AND ORGANISMS TO INCREASE DESICCATION TOLERANCE, AND BUILDING A NATIONAL COMMUNITY OF DESICCATION SCIENTISTS. RESEARCH AT WALII WILL IMPACT SOCIETY BY FINDING NEW, DESICCATION-TOLERANCE-BASED STRATEGIES FOR CROP LOSS PREVENTION, DEVELOPING DRY STORAGE SOLUTIONS FOR STORING MEDICINES CURRENTLY STORED COLD, AND MITIGATING ONGOING DECREASES IN SPECIES DIVERSITY. ESTABLISHING A NATIONAL, INTEGRATED RESEARCH COMMUNITY REQUIRES AN EXPERT, MULTIDISCIPLINARY WORKFORCE, AND INTEGRATION WITH THE PUBLIC. TO THAT END, THE WALII TRAINING PROGRAMS WILL SUPPORT CAREER DEVELOPMENT FOR OVER 100 SCIENTISTS FROM DIVERSE BACKGROUNDS AT ALL CAREER STAGES, AND ITS OUTREACH INITIATIVES WILL INVITE THE PUBLIC TO JOIN WALII?S SCIENTISTS IN DESICCATION TOLERANCE EXPERIMENTS. CONCEPTS AND TOOLS IN LIFE SCIENCES HAVE BEEN MADE PRIMARILY IN THE CONTEXT OF FULLY HYDRATED SYSTEMS. WALII WILL STUDY THE INTERACTION OF LIFE AND WATER ACROSS TIMESCALES AND HYDRATION STATES IN DIVERSE ORGANISMS, USING FOUR INTERTWINED THEMES: 1) PHYSICAL AND MOLECULAR DETERMINANTS OF DESICCATION TOLERANCE; 2) MOLECULAR AND CELLULAR REHYDRATION RESPONSES ACROSS THE CONTINUUM OF DESICCATION SENSITIVITY; 3) THE ROLE(S) OF INTRINSICALLY DISORDERED PROTEINS IN CONFERRING DESICCATION TOLERANCE; AND 4) SHORT- AND LONG-TERM EVOLUTIONARY HISTORIES OF DESICCATION TOLERANCE. THE MULTISCALE, TRANSDISCIPLINARY STUDIES OF ANHYDROBIOSIS AT WALII AIM TO IGNITE A TRANSFORMATIVE NEW FIELD OF SOLID-STATE BIOLOGY, FOCUSED FIRST ON MODELING FUNCTION AND DYSFUNCTION OF BIOMOLECULES, CELLS, TISSUES, AND ORGANISMS UNDER DESICCATION STRESS. NEW METHODS AND APPROACHES WILL BE ESSENTIAL, INCLUDING BETTER PROTOCOLS FOR SEEDBANK PRESERVATION AND STABILIZING PLANT SEXUAL REPRODUCTION, BETTER WATER-RESISTANT MATERIALS AND WATER-RETENTION STRATEGIES, AND SENSITIVE IN VIVO TOOLS FOR SENSING AND MANIPULATING CELLULAR RESPONSES TO DESICCATION. WALII COMBINES THE EXPERTISE OF RESEARCHERS FROM SEVERAL DISCIPLINES SUCH AS BIOPHYSICS, CELL BIOLOGY, COMPUTATIONAL BIOLOGY, DESICCATION TOLERANCE, EVOLUTIONARY BIOLOGY, ECOLOGY, GENETICS, AND PLANT, ANIMAL, SEED, FUNGAL, AND POLLEN PHYSIOLOGY AND DIVERSE ORGANIZATIONS SUCH AS NON-PROFIT RESEARCH INSTITUTES, UNIVERSITIES, HISPANIC SERVING INSTITUTIONS, AND PRIMARILY UNDERGRADUATE INSTITUTIONS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

TRANSLATIONAL GENE THERAPY FOR CNGB1 RETINITIS PIGMENTOSA

INCREASE THE TOTAL ESTIMATED AMOUNT OF THE AGREEMENT BY $2,987,600.00FROM $5,123,753.00 TO $8,111,353.00;INCREASE THE TOTAL OBLIGATED AMOUNT OF THE

MICHIGAN STATE UNIVERSITY EXTENSION FFY-13 PROGRAMS

FOUR YEAR ASSOCIATE COOPERATIVE AGREEMENT WITH THE DEPARTMENT OF AGRICULTURAL ECONOMICS MICHIGAN STATE UNIVERSITY (MSU) FOR THE IMPLEMENTATION OF TH

MATERNAL HEALTH MULTILEVEL INTERVENTION/S FOR RACIAL EQUITY (MIRACLE) CENTER - SPECIFIC AIMS (OVERALL). THE GOAL OF THE PROPOSED MULTILEVEL INTERVENTIONS TO ADVANCE MATERNAL HEALTH EQUITY (MIRACLE) CENTER IS TO REDUCE PREGNANCY-RELATED AND PREGNANCY-ASSOCIATED MATERNAL MORBIDITY AND MORTALITY (PRAMM) DISPARITIES IN AFRICAN AMERICAN, HISPANIC, AND RURAL POPULATIONS THROUGH INNOVATIVE AND CULTURALLY REL- EVANT COMMUNITY-PARTNERED EFFECTIVENESS AND IMPLEMENTATION RESEARCH. THIS CENTER WILL ADDRESS THE NEED FOR MULTILEVEL, COMMUNITY-CENTERED, EQUITY-FOCUSED INTERVENTIONS DEVELOPED AND TESTED WITH AN EMPHASIS ON SCALA- BILITY AND SUSTAINMENT TO ADDRESS PRAMM DISPARITIES. THE PROPOSED MIRACLE CENTER IS INNOVATIVE BECAUSE IT: (1) TESTS COMPLEMENTARY, MULTILEVEL PREGNANCY-TO-POSTPARTUM INTERVENTIONS OPERATING ACROSS MULTIPLE HEALTH SYS- TEMS AND SETTINGS; (2) ADDRESSES AND MEASURES A WIDE RANGE OF PRAMM CONDITIONS (INCLUDING NON-SEVERE MOR- BIDITY AND PREGNANCY-ASSOCIATED MORTALITY, WHICH ARE LESS COMMONLY MEASURED), AS WELL AS SEVERE MATERNAL MORBIDITY (SMM) AND PREGNANCY-RELATED MORTALITY; (3) ANALYZES MAIN EFFECTS WITHIN EACH PROJECT AND SYNERGISTIC EFFECTS ACROSS PROJECTS, WHICH TARGET DIFFERENT LEVELS AND SOURCES OF DISPARITIES; (4) USES A STATEWIDE LINKED MED- ICAID DATASET (CLAIMS, VITAL RECORDS, SCREENING DATA) TO EVALUATE COMMON OUTCOMES, ALLOWING FOR DATA HARMONI- ZATION ACROSS PROJECTS AND WITH OTHER CENTERS NATIONALLY; AND (5) FOCUSES ON THE UNDERSTUDIED IMPLEMENTATION SCIENCE CONCEPTS OF SCALE-UP AND SUSTAINMENT. THE CENTER IS SIGNIFICANT BECAUSE IT: (1) DEVELOPS AND TESTS NOVEL APPROACHES TO ADDRESSING DETERMINANTS OF INEQUITIES AT MULTIPLE LEVELS AND IN MULTIPLE SYSTEMS, (2) TESTS THESE POPULATION-LEVEL EQUITY-FOCUSED INTERVENTIONS IN 20 MICHIGAN COUNTIES, COVERING A POPULATION OF >7 MILLION; AND (3) USES AN EQUITABLY PARTNERED CENTER STRUCTURE, WITH ACADEMIC AND HEALTH SYSTEM OR COMMUNITY PIS OF THE CENTER AND OF EACH COMPONENT. ALL THESE FEATURES ENHANCE UTILITY AND IMPACT OF THE PROPOSED WORK. THROUGH THREE R01-SCOPE PROJECTS IMPLEMENTING AND TESTING MULTILEVEL INTERVENTIONS, AND COMMUNITY PARTNERSHIP AND TRAINING COMPONENTS THE CENTER WILL ACCOMPLISH THE FOLLOWING AIMS: (1) EVALUATE EFFECTIVENESS, COST-EFFECTIVE- NESS, IMPLEMENTATION, AND POPULATION-WIDE IMPACT OF INNOVATIVE AND CULTURALLY RELEVANT MULTILEVEL INTERVENTIONS TO ELIMINATE PRAMM DISPARITIES THROUGH THREE R01-SCOPE PROJECTS; (2) GENERATE AND SCALE INNOVATIVE AP- PROACHES & PARTNERSHIPS FOR ELIMINATING PRAMM DISPARITIES; (3) MAXIMIZE SCALABILITY, SUSTAINABILITY, CULTURAL REL- EVANCE, AND BROAD DISSEMINATION OF IDENTIFIED APPROACHES; (4) INCREASE RESEARCH, PRACTICE, AND POLICY CAPACITY FOR ELIMINATING PRAMM DISPARITIES. THIS CENTER IS ROOTED IN A CULTURALLY INFORMED MULTI-DISCIPLINARY RESEARCH COMMUNITY WITH INVOLVEMENT OF LONGSTANDING COMMUNITY, HEALTH, AND POLICY PARTNERS IN ALL PHASES OF THE CENTER’S WORK, AND PARTNERSHIP WITH BLACK AND HISPANIC MEDICAID-ELIGIBLE MOTHERS AND THEIR FAMILIES IN URBAN AND RURAL SETTINGS. WITH IN-KIND FINANCIAL SUPPORT FROM ACADEMIC AND HEALTH INSTITUTIONS, THE CENTER WILL GENERATE SCALABLE AND SUSTAINABLE APPROACHES FOR SAVING MATERNAL LIVES AND ENDING PREVENTABLE AND UNEQUAL MATERNAL SUFFERING.

A MULTI-INSTITUTIONAL, MULTIDISCIPLINARY CENTER IN THE GREAT LAKES REGION IS PROPOSED TO INVESTIGATE THE INTER-RELATIONSHIPS BETWEEN AIR POLLUTION AN

A CULTURALLY RESPONSIVE PROJECT-BASED LEARNING INTERVENTION IN SECONDARY SCIENCE IN ALABAMA AND NORTH CAROLINA

SUICIDE RISK REDUCTION IN THE YEAR FOLLOWING JAIL RELEASE: THE SPIRIT TRIAL (SUICIDE PREVENTION INTERVENTION FOR AT-RISK INDIVIDUALS IN TRANSITION)

MICHIGAN STATE UNIVERSITY EXTENSION SMITH-LEVER PROGRAMS FOR FFY-16

MICHIGAN STATE UNIVERSITY - LIFE SCIENCE COMPLEX: NURSING RESEARCH ADDITION

MICHIGAN STATE UNIVERSITY EXTENSION SMITH-LEVER PROGRAMS FOR FFY-15

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

ERIN CRC: HOST-MICROBIOTA-PATHOGEN INTERACTIONS GOVERN ENTERIC HEALTH AND DISEASE

MULTIDISCIPLINARY TRAINING IN ENVIRONMENTAL TOXICOLOGY

FRIB THEORY CENTER - A PATH FOR THE SCIENCE AT FRIB

SUSTAINING RESPONSIVE AND RIGOROUS TEACHING BASED ON CARBON: TRANSFORMATIONS IN MATTER AND ENERGY

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP) -THE NATIONAL SCIENCE FOUNDATION (NSF) GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP) IS A HIGHLY COMPETITIVE, FEDERAL FELLOWSHIP PROGRAM. GRFP HELPS ENSURE THE VITALITY AND DIVERSITY OF THE SCIENTIFIC AND ENGINEERING WORKFORCE OF THE UNITED STATES. THE PROGRAM RECOGNIZES AND SUPPORTS OUTSTANDING GRADUATE STUDENTS WHO ARE PURSUING RESEARCH-BASED MASTER'S AND DOCTORAL DEGREES IN SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS (STEM) AND IN STEM EDUCATION. THE GRFP PROVIDES THREE YEARS OF FINANCIAL SUPPORT FOR THE GRADUATE EDUCATION OF INDIVIDUALS WHO HAVE DEMONSTRATED THEIR POTENTIAL FOR SIGNIFICANT RESEARCH ACHIEVEMENTS IN STEM AND STEM EDUCATION. THIS AWARD SUPPORTS THE NSF GRADUATE FELLOWS PURSUING GRADUATE EDUCATION AT THIS GRFP INSTITUTION. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

LARGE ANIMAL FACILITY FOR IMAGING AND IMAGE-GUIDED THERAPIES AT MSU - ABSTRACT PRECISION HEALTH IS AN EMERGING PARADIGM IN HEALTHCARE THAT FOCUSES ON EARLY DETECTION AND MOLECULAR DETERMINANTS OF DISEASE. MICHIGAN STATE UNIVERSITY (MSU) HAS LAUNCHED A UNIVERSITY-WIDE INITIATIVE TO BRING THE PRINCIPLES OF PRECISION HEALTH INTO ITS HEALTHCARE SYSTEMS. THE SUCCESS OF THIS INITIATIVE DEPENDS, IN LARGE PART, ON OUR ABILITY TO OBTAIN RELEVANT DATA FROM PREDICTIVE PRE-CLINICAL ANIMAL MODELS AND EFFECTIVE TRANSLATIONAL RESEARCH. ADVANCES IN MOLECULARLY TARGETED DIAGNOSTIC AND THERAPEUTIC AGENTS, THE CORNERSTONES OF PRECISION MEDICINE, REQUIRE RELIABLE TESTING IN INFORMATIVE ANIMAL MODELS OF HUMAN BIOLOGY. SMALL LABORATORY ANIMALS (RODENTS) COMMONLY USED IN BIOMEDICAL RESEARCH ARE OFTEN NOT SUITABLE FOR STUDYING PATHOLOGIES WHERE PHYSIOLOGY, HUMAN MARKERS, PHYSICAL SIZE, GESTATION LENGTH, LIFESPAN, AND OTHER HUMAN-LIKE FEATURES ARE KEY CONTRIBUTORS TO DISEASE. USE OF LARGER ANIMAL SPECIES FOR RESEARCH, INCLUDING DOGS, PIGS AND SHEEP, CAN OVERCOME MANY OF THESE HURDLES. IT IS WIDELY ACCEPTED THAT IN VIVO IMAGING PLAYS A PIVOTAL ROLE IN NEARLY ALL AREAS OF BIOMEDICAL RESEARCH AND CLINICAL PRACTICE, AND THE IMPORTANCE OF ITS ROLE WILL ONLY INCREASE WITH THE DEVELOPMENT OF NEW AGENTS AND THERAPIES. HOWEVER, IMAGING DATA OBTAINED IN SMALL ANIMAL IMAGING SYSTEMS CANNOT ALWAYS BE DIRECTLY TRANSLATED TO STUDIES IN HUMANS. CLEARLY, STUDYING LARGE ANIMAL MODELS USING CLINICAL SCANNERS WOULD PRODUCE DATA THAT ARE CLOSEST TO WHAT WE EXPECT IN HUMANS, AND WOULD BETTER INFORM TRANSLATIONAL STUDIES. FURTHER, THE ABILITY TO STUDY COMPARATIVE DISEASES THAT OCCUR SPONTANEOUSLY IN DOMESTICATED SPECIES, AS PART OF CLINICAL STUDIES OF CLIENT- OWNED ANIMALS, WILL ADD FURTHER TO TRANSLATIONAL RELEVANCE AND DATA OUTCOMES. FOR THESE REASONS AND TO ADVANCE THE CLINICAL RELEVANCE OF ANIMAL MODELS, WE ARE REQUESTING FUNDS TO DEVELOP A MULTI-SPECIES LARGE ANIMAL IMAGING FACILITY AT MSU. THIS FACILITY WILL BE EQUIPPED WITH A STATE-OF-THE-ART HIGH-END CLINICAL IMAGING SYSTEM (PET/MRI, MMR BIOGRAPH, SIEMENS) THAT WOULD SERVE MSU’S DIVERSE BIOMEDICAL SCIENTIFIC AND CLINICAL COMMUNITIES. RESEARCHERS WILL USE THIS FACILITY FOR STUDIES OF LARGE RESEARCH ANIMALS, AND CLIENT-OWNED COMPANION ANIMALS TO DEVELOP IMAGING AND IMAGE-GUIDED THERAPY APPROACHES WITH FOCUS ON HUMAN PATHOLOGIES LINKED TO SIGNIFICANT MORTALITY RATES (E.G., CARDIOVASCULAR DISEASE, CANCER, AND DIABETES). THIS MULTIDISCIPLINARY FACILITY WILL ALSO SUPPORT ONGOING CLINICAL TRIALS IN HUMAN SUBJECTS AND SERVE AS A TRAINING GROUND FOR UNDERGRADUATE, GRADUATE AND POSTDOCTORAL TRAINEES FROM 6 COLLEGES, 12 DEPARTMENTS AND 7 PROGRAMS. PERFORMING RESEARCH ON A FULL SPECTRUM OF HUMAN AND ANIMAL DISEASE MODELS. THIS NEW BIOMEDICAL IMAGING FACILITY, IN COMBINATION WITH HUMAN AND VETERINARY EXPERTISE AT MSU, CREATES AN EXTRAORDINARY OPPORTUNITY TO PERFORM PRE-CLINICAL, CLINICAL AND TRANSLATIONAL RESEARCH USING CLINICAL IMAGING EQUIPMENT. THESE CAPABILITIES WILL PROMOTE HIGH-LEVEL COLLABORATIONS BETWEEN MSU AND INVESTIGATORS AT REGIONAL AND NATIONAL INSTITUTIONS TO ULTIMATELY CHAMPION AND ADVANCE A PREMIERE PROGRAM IN PRECISION HEALTH AND COMPARATIVE MEDICINE, BENEFITING BOTH HUMAN AND ANIMAL HEALTH IN THE DIAGNOSIS AND TREATMENT OF DISEASE.

THE KBS LTER PROJECT: LONG-TERM ECOLOGICAL RESEARCH IN ROW-CROP AGRICULTURE

CUCCAP: LEVERAGING APPLIED GENOMICS TO INCREASE DISEASE RESISTANCE IN CUCURBIT CROPS

**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** PRODUCERS AND PROCESSORS OF CUCURBIT CROPS (WATERMELONS, MELONS, CUCUMBERS, WINTER AND SUMMER SQUASHES) CONSISTENTLY IDENTIFY DISEASES AS THEIR PRIMARY CONSTRAINT. THESE DISEASES CAUSE SEVERE REDUCTIONS IN YIELD AND QUALITY, INCREASED LABOR AND EXPENSES FOR DISEASE CONTROL, NEGATIVE ENVIRONMENTAL IMPACTS FROM APPLICATION OF PESTICIDES, LOSS OF PROFITABILITY, AND POTENTIAL OUTRIGHT LOSS OF THE CROP IN THE FIELD OR AT POINT OF SALE. THE MOST COST-EFFECTIVE, ENVIRONMENTALLY DESIRABLE SOLUTION IS DISEASE-RESISTANT CULTIVARS DEPLOYED WITH EFFECTIVE INTEGRATED DISEASE MANAGEMENT STRATEGIES. TO ACHIEVE THIS OUTCOME, CUCCAP2 WILL DEVELOP AND DELIVER: ADVANCED GENOMIC, BIOINFORMATIC, AND BREEDING TOOLS; DISEASE RESISTANT MATERIALS; AND DISEASE MANAGEMENT STRATEGIES AND ECONOMIC ANALYSES FOR CRITICAL DISEASES THREATENING CUCURBIT PRODUCTION. FOUR CROP TEAMS (WATERMELON, MELON, CUCUMBER, SQUASH) TOGETHER WITH GENOMICS/BIOINFORMATICS, AND INTEGRATED DISEASE MANAGEMENT TEAMS, WILL TAKE AN INTEGRATED RESEARCH AND EXTENSION/OUTREACH APPROACH TO: DEVELOP NOVEL BIOINFORMATIC, PAN-GENOME AND GENETIC MAPPING TOOLS; UTILIZE GENOMIC APPROACHES TO IDENTIFY, MAP, AND DEVELOP MARKERS FOR RESISTANCES TO PRIORITY DISEASES IDENTIFIED BY CUCURBIT INDUSTRIES; INTRODUCE AND COMBINE RESISTANCES IN ADVANCED BREEDING LINES; AND PERFORM MULTI-LOCATION, MULTI-ISOLATE TRIALS OF RESISTANCES TO IMPROVE INTEGRATED DISEASE MANAGEMENT AND ASSESS ECONOMIC IMPACTS. THIS PROJECT WILL EXPAND ON THE NATION-WIDE, INTERDISCIPLINARY COLLABORATIONS ESTABLISHED IN CUCCAP1, BRINGING TOGETHER BIOINFORMATICIANS, GENOMICISTS, GENETICISTS, BREEDERS, PLANT PATHOLOGISTS, AND ECONOMISTS, TO PROVIDE GENOMIC TOOLS FOR PUBLIC AND PRIVATE BREEDERS TO ACCELERATE BREEDING FOR DISEASE RESISTANCE IN CUCURBIT CROPS, AND DEVELOP AND PROVIDE READILY ACCESSIBLE DISEASE CONTROL INFORMATION, DISEASE MANAGEMENT STRATEGIES, AND ESTIMATES OF ECONOMIC NET RETURNS FOR CUCURBIT PRODUCERS. THIS PROJECT ALSO WILL BENEFIT THE LARGER SCIENTIFIC AND PRIVATE BREEDING AND CROP PRODUCTION COMMUNITIES BY PROVIDING TRANSDISCIPLINARY STEM TRAINING FOR UNDERGRADUATE, GRADUATE STUDENTS AND POST-DOCTORAL RESEARCHERS, INCLUDING PARTICIPANTS FROM HISTORICALLY BLACK (HBCU) AND HISPANIC-SERVING (HIS) UNIVERSITIES.

FEED THE FUTURE BIOTECHNOLOGY PARTNERSHIP FOR EGGPLANT (CORNELL)

COMPOSITE MATERIALS RESEARCH COOPERATIVE AGREEMENT

THE PURPOSE OF THIS PROGRAM IS TO INCREASE THE ANALYTICAL CAPABILITY OF THE GOVERNMENT OF MALI TO HELP BETTER INFORM KEY POLICY DEVELOPMENT IN AGRICU

WINDOWS ON THE UNIVERSE: NUCLEAR ASTROPHYSICS AT FRIB -THE NUCLEAR ASTROPHYSICS GROUP AT THE FACILITY FOR RARE ISOTOPE BEAMS (FRIB) WILL USE ACCELERATOR FACILITIES TO ADDRESS THE LONG-STANDING QUESTION ABOUT THE ORIGIN OF THE ELEMENTS IN THE UNIVERSE, AND HOW NEW ELEMENTS CONTINUE TO BE PRODUCED IN VARIOUS ASTROPHYSICAL SITES. THE GOAL IS TO RESTAGE IN THE LABORATORY THE SAME NUCLEAR REACTIONS THAT PRODUCE NEW ELEMENTS IN NOVA AND SUPERNOVA EXPLOSIONS, MERGING NEUTRON STARS, ACCRETING NEUTRON STARS, AND OTHER EXTREME ASTROPHYSICAL ENVIRONMENTS. THE REACTING ATOMIC NUCLEI ARE UNSTABLE AND NEED TO BE PRODUCED AT A RARE ISOTOPE FACILITY, LIKE FRIB, OR OTHER WORLD-LEADING LABORATORIES. REACTION EXPERIMENTS ARE CARRIED OUT, WHERE THE RELEVANT ISOTOPES CAN BE PRODUCED AND DETECTED WITHIN FRACTIONS OF A SECOND. ALTERNATIVELY, THE PROPERTIES OF THE EXOTIC NUCLEI THAT PARTICIPATE IN THE ASTROPHYSICAL REACTIONS ARE STUDIED TO INFER HOW THEY WOULD REACT WITH OTHER NUCLEI. THE NEW NUCLEAR INFORMATION WILL BE IMPLEMENTED IN COMPUTER MODELS THAT ARE THEN CONFRONTED WITH MULTI-MESSENGER ASTRONOMICAL OBSERVATIONS USING INFRARED, VISIBLE LIGHT, GAMMA RAYS, GRAVITATIONAL WAVES, NEUTRINOS, AND STARDUST FROM VARIOUS ASTROPHYSICAL SITES. ONLY IN COMBINATION WITH THE RELEVANT NUCLEAR DATA DO THESE OBSERVATIONS BECOME TRULY ?WINDOWS ON THE UNIVERSE? AND REVEAL WHAT ELEMENTS ARE CREATED IN DIFFERENT ASTROPHYSICAL ENVIRONMENTS. THE PROPOSED PROGRAM OF STUDIES AT THE INTERSECTION OF NUCLEAR PHYSICS AND ASTROPHYSICS WILL ATTRACT A DIVERSE GROUP OF UNDERGRADUATE AND GRADUATE STUDENTS, AS WELL AS POSTDOCS TO NUCLEAR SCIENCE, TAKING ADVANTAGE OF THE COMPELLING SCIENCE OF THE NSF BIG IDEA WINDOWS ON THE UNIVERSE. STUDENTS AND POSTDOCS WILL RECEIVE BROAD INTERDISCIPLINARY TRAINING TAKING ADVANTAGE OF THE SYNERGISTIC CONNECTIONS NATIONALLY AND INTERNATIONALLY WITHIN THE IRENA NETWORK AND ALSO LOCALLY AT MICHIGAN STATE UNIVERSITY WITH THE ASTRONOMY GROUP AND THE NEW DEPARTMENT OF COMPUTATIONAL MATHEMATICS SCIENCE AND ENGINEERING. THIS WILL CONTINUE THE EXCELLENT EDUCATIONAL TRACK RECORD OF THE GROUP IN PREPARING STUDENTS AND POSTDOCS FOR SUCCESSFUL CAREERS IN ACADEMIA, INDUSTRY AND US NATIONAL LABORATORIES AND WILL THUS CONTRIBUTE TO THE WORKFORCE WITH NUCLEAR SCIENCE EXPERTISE THAT IS CRITICAL FOR THE NATION. TO FURTHER INCREASE INTEREST IN STEM CAREERS IN GENERAL, AND NUCLEAR-SCIENCE CAREERS SPECIFICALLY, ESPECIALLY AMONG WOMEN AND MINORITIES, THE PI TEAM WILL CONTINUE TO ORGANIZE THE VERY SUCCESSFUL ANNUAL NUCLEAR SCIENCE SUMMER SCHOOL (NS3). NS3 PROVIDES UNDERGRADUATE STUDENTS ACCESS TO NUCLEAR SCIENCE EDUCATION THAT IS NOT AVAILABLE AT THEIR HOME INSTITUTIONS AND TAKES ADVANTAGE OF THE COMPELLING SCIENCE IN THIS PROPOSAL TO ATTRACT AND EDUCATE STUDENTS. IN THE ERA OF MULTI-MESSENGER ASTRONOMY THE INTERPRETATION OF ASTRONOMICAL OBSERVATIONS USING LIGHT, GAMMA-RAYS, GRAVITATIONAL WAVES, AND NEUTRINOS REQUIRES AN UNDERSTANDING OF THE NUCLEAR PROCESSES THAT CREATE THESE VARIOUS MESSENGERS. WE PROPOSE TO CONTINUE THE EXPERIMENTAL NUCLEAR ASTROPHYSICS PROGRAM AT FRIB AND OTHER FACILITIES TO PROVIDE THIS IMPORTANT NUCLEAR PHYSICS INPUT. WE WILL CARRY OUT A SYNERGISTIC AND INTERCONNECTED EXPERIMENTAL PROGRAM USING STABLE AND RARE ISOTOPE BEAMS THAT EMPLOYS A WIDE VARIETY OF EXISTING EXPERIMENTAL EQUIPMENT, AND CONTINUED DEVELOPMENT OF KEY EXPERIMENTAL CAPABILITIES. THE PROPOSED EXPERIMENTS EITHER MEASURE ASTROPHYSICAL REACTIONS DIRECTLY AS THEY OCCUR IN NOVA AND SUPERNOVA EXPLOSIONS, NEUTRON STAR MERGERS, ACCRETING NEUTRON STARS, AND OTHER ASTROPHYSICAL SITES, OR PROVIDE INDIRECT CONSTRAINTS ON SUCH REACTIONS. THE PROGRAM TAKES ADVANTAGE OF THE UNIQUE CAPABILITIES OF FRIB AND OTHER CURRENT FACILITIES AROUND THE WORLD IN A COMPLEMENTARY WAY. INTERPRETING MULTI-MESSENGER OBSERVATIONS WITH ACCURATE NUCLEAR PHYSICS OBTAINED IN THE PROPOSED PROGRAM WILL OPEN A NEW WINDOW ON THE UNIVERSE PROVIDING INSIGHT INTO ELEMENT SYNTHESIS AND NUCLEAR MATTER IN EXTREME ASTROPHYSICAL ENVIRONMENTS. THIS PROVIDES THE OPPORTUNITY TO ADDRESS LONG STANDING QUESTIONS IN NUCLEAR SCIENCE IDENTIFIED IN THE NP2010 NATIONAL ACADEMY STUDY AND THE 2015 NUCLEAR SCIENCE LONG RAGE PLAN, INCLUDING THE QUESTIONS THE AWARDEES AIM TO ADDRESS HERE ?WHERE DO THE CHEMICAL ELEMENTS COME FROM, AND HOW DID THEY EVOLVE??, ?HOW DOES STRUCTURE ARISE IN THE UNIVERSE AND HOW IS IT RELATED TO THE EMERGENCE OF THE ELEMENTS IN STARS AND EXPLOSIVE PROCESSES??, AND ?WHAT IS THE NATURE OF MATTER AT EXTREME TEMPERATURES AND DENSITIES?? THESE QUESTIONS WILL BE ADDRESSED BY ADVANCING OUR KNOWLEDGE OF STELLAR NUCLEAR PROCESSES THROUGH LABORATORY EXPERIMENTS IN CLOSE COLLABORATION WITH NUCLEAR THEORISTS AND ASTROPHYSICISTS. THE GROUP WILL PERFORM EXPERIMENTS PROVIDING NEW DATA ON NUCLEAR PROCESSES IN NOVAE, X-RAY BURSTS, AND SUPERNOVAE, WILL MEASURE A RANGE OF NUCLEAR PROPERTIES NEEDED TO UNDERSTAND THE SYNTHESIS OF HEAVY ELEMENTS BY RAPID AND INTERMEDIATE NEUTRON CAPTURE, AND WILL STUDY WEAK INTERACTIONS IN SUPERNOVAE AND NEUTRON STARS. THIS PROJECT ADVANCES THE OBJECTIVES OF WINDOWS ON THE UNIVERSE: THE ERA OF MULTI-MESSENGER ASTROPHYSICS, ONE OF THE 10 BIG IDEAS FOR FUTURE NSF INVESTMENTS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THIS PROPOSAL RESPONDS TO THE CURRENT CRISIS THREATENING POTATO PRODUCTION IN THE U.S. REGARDING INSECT MANAGEMENT. THE U.S. POTATO INDUSTRY HAS BEEN MOST COMMONLY USING NEONICOTINOID INSECTICIDES TO TARGET KEY INSECT PESTS, BUT THIS MODE OF ACTION GROUP IS NOW INCREASINGLY UNDER SCRUTINY BY FOOD / NURSERY RETAILERS AND REGULATORS. THE USE OF THIS PRODUCT IS THEREFORE IN JEOPARDY AND THE POTATO INDUSTRY NEEDS MORE ROBUST AND ENDURING ALTERNATIVES THAT ARE ENVIRONMENTALLY SUSTAINABLE AND ADDRESS CONSUMER CONCERNS. THESE ALTERNATIVES WILL RELY MORE HEAVILY ON BIOLOGICAL, ECOLOGICAL AND ENVIRONMENTAL INFORMATION. WE ALSO ADDRESS IMPORTANT SOCIAL AND ECONOMIC IMPACTS AND FACILITATE THE ADOPTION OF NEW STRATEGIES. MOST OF OUR OBJECTIVES ARE FOCUSED ON SHORT-TERM DELIVERABLES THAT CAN RESPOND TO THE U.S. POTATO INDUSTRY'S CURRENT CRISIS. THE LONG-TERM GOALS ARE TO CONTINUE ADOPTION OF STRATEGIES DEVELOPED IN THIS PROPOSAL LONG INTO THE FUTURE AND TO CONTINUE TO BUILD ON IT. TO ADDRESS THESE ISSUES, WE DEVELOPED THE FOLLOWING OBJECTIVES: (1.) DEVELOP AND EVALUATE NON-NEONICOTINOID PEST MANAGEMENT PROGRAMS; (2.) DEVELOP PEST PREDICTION AND DECISION-MAKING TOOLS; (3.) EVALUATE THE SOCIOECONOMIC INFLUENCES AND IMPACTS ASSOCIATED WITH THE TRANSITION FROM NEONICOTINOIDS TO NEW PEST MANAGEMENT STRATEGIES, (4) AND FACILITATE ADOPTION OF NEW PEST MANAGEMENT STRATEGIES. THE OUTCOMES OF THE PROJECT WILL 1) FIND IMMEDIATE SOLUTIONS FOR MANAGING POTATO INSECT PESTS WITHOUT USING NEONICOTINOIDS, 2) CREATE A HEALTHY SEED SUPPLY FOR U. S. SEED MARKETS, 3) IDENTIFY LESS TOXIC PESTICIDES WITH FEWER NEGATIVE IMPACTS, AND 5) INCREASE RELIANCE ON DECISION SUPPORT TOOLS TO REDUCE PRODUCTION COSTS.

AMERICAN RECOVERY AND REINVESTMENT ACT - PCC - EVIDENCE BASED COMPUTER CENTERS II

STRENGTHEN SENEGAL S POLICY AND ENABLING ENVIRONMENT FOR INCREASED PUBLIC AND PRIVATE AGRICULTURE SECTOR INVESTMENT

CAMRA WILL DEVELOP CRITICALLY REVIEWED AND INTERPRETED SETS OF MODELS, TOOLS, AND INFORMATION THAT WILL BE USED IN A CREDIBLE RISK ASSESSMENT FRAME

AGING AND PARKINSON'S DISEASE: MODELS OF THERAPEUTICS AND NEUROLOGIC COMORBIDITY

RESOURCE FOR QUANTITATIVE ELEMENTAL MAPPING FOR THE LIFE SCIENCES

UNRAVELING THE HETEROZYGOSITY, ALLELIC COMPOSITION, AND COPY NUMBER VARIATION OF POTATO

WINDOWS ON THE UNIVERSE: NUCLEAR ASTROPHYSICS AT THE NSCL

THE MISSION OF MSU AGBIORESEARCH IS TO ENGAGE IN INNOVATIVE, LEADING?EDGE RESEARCH THAT COMBINES SCIENTIFIC EXPERTISE WITH PRACTICAL EXPERIENCE TO GENERATE ECONOMIC PROSPERITY, SUSTAIN NATURAL RESOURCES, AND ENHANCE THE QUALITY OF LIFE IN MICHIGAN, THE NATION AND THE WORLD. AS WE OFTEN DESCRIBE AS "FUNDAMENTAL RESEARCH WITH AN INTENDED OUTCOME." ALL OF OUR RESEARCH IS AIMED AT SOLVING PROBLEM OR CREATING A NEW OPPORTUNITY. THE 340 PLUS RESEARCHERS ACROSS CAMPUS STRIVE TO MAINTAIN A BALANCE BETWEEN BASIC AND APPLIED RESEARCH AND RELY HEAVILY ON THE INPUT OF THEIR CONSTITUENTS IN IDENTIFYING RESEARCH PRIORITIES. WITH HATCH FUNDING, WE WILL: INCREASE FARMERS' SUCCESS WITH PROTECTING THE ENVIRONMENT, ENSURING FOOD SAFETY, REACHING NEW MARKETS, AND ADVANCING AGRICULTURE THROUGH APPLIED RESEARCH; CONDUCT RESEARCH ON SELECTING PLANTS AND ANIMALS WITH DESIRABLE TRAITS AND ON NEW METHODS TO COMBAT DISEASES AND PARASITES; STUDY NUTRITION AND ANIMAL MANAGEMENT SYSTEMS; DEVELOP INTEGRATED CROP AND SOIL MANAGEMENT SYSTEMS TO MEET PRODUCTION AND ENVIRONMENTAL GOALS; ENHANCE THE PRODUCTION AND PROFITABILITY OF SMALL?SCALE AGRICULTURE PROJECTS AND IMPROVE COMMUNITY WELLNESS; USE EDUCATIONAL PROCESSES TO FACILITATE THE INCORPORATION OF RENEWABLE ENERGY INTO HOUSEHOLDS, GOVERNMENTAL OFFICES, AND BUSINESSES; INCREASE THE CAPACITY TO DEVELOP FOREST AND AGRICULTURAL?BASED RENEWABLE RESOURCES IN ECOLOGICALLY AND ECONOMICALLY SUSTAINABLE WAYS.

MICHIGAN STATE UNIVERSITY AGBIORESEARCH HATCH PROGRAMS FOR FFY-19

THE CENTER FOR CATALYSIS IN BIOMIMETIC CONFINEMENT (CCBC)

THE MISSION OF MSU AGBIORESEARCH IS TO ENGAGE IN INNOVATIVE, LEADING?EDGE RESEARCH THAT COMBINES SCIENTIFIC EXPERTISE WITH PRACTICAL EXPERIENCE TO GENERATE ECONOMIC PROSPERITY, SUSTAIN NATURAL RESOURCES, AND ENHANCE THE QUALITY OF LIFE IN MICHIGAN, THE NATION AND THE WORLD. AS WE OFTEN DESCRIBE AS FUNDAMENTAL RESEARCH WITH AN INTENDED OUTCOME. ALL OF OUR RESEARCH IS AIMED AT SOLVING PROBLEMS OR CREATING A NEW OPPORTUNITY. THE 340 PLUS RESEARCHERS ACROSS CAMPUS STRIVE TO MAINTAIN A BALANCE BETWEEN BASIC AND APPLIED RESEARCH AND RELY HEAVILY ON THE INPUT OF THEIR CONSTITUENTS IN IDENTIFYING RESEARCH PRIORITIES. WITH HATCH FUNDING, WE WILL: INCREASE FARMERS' SUCCESS WITH PROTECTING THE ENVIRONMENT, ENSURING FOOD SAFETY, REACHING NEW MARKETS, AND ADVANCING AGRICULTURE THROUGH APPLIED RESEARCH; CONDUCT RESEARCH ON SELECTING PLANTS AND ANIMALS WITH DESIRABLE TRAITS AND ON NEW METHODS TO COMBAT DISEASES AND PARASITES; STUDY NUTRITION AND ANIMAL MANAGEMENT SYSTEMS; DEVELOP INTEGRATED CROP AND SOIL MANAGEMENT SYSTEMS TO MEET PRODUCTION AND ENVIRONMENTAL GOALS; ENHANCE THE PRODUCTION AND PROFITABILITY OF SMALL?SCALE AGRICULTURE PROJECTS AND IMPROVE COMMUNITY WELLNESS; USE EDUCATIONAL PROCESSES TO FACILITATE THE INCORPORATION OF RENEWABLE ENERGY INTO HOUSEHOLDS, GOVERNMENTAL OFFICES, AND BUSINESSES; INCREASE THE CAPACITY TO DEVELOP FOREST AND AGRICULTURAL?BASED RENEWABLE RESOURCES IN ECOLOGICALLY AND ECONOMICALLY SUSTAINABLE WAYS.

FFY-20 MICHIGAN STATE UNIVERSITY HATCH REGULAR RESEARCH FUND

MICHIGAN STATE UNIVERSITY FEDERAL FISCAL YEAR 2022 HATCH REGULARRESEARCH FUND

GENETIC INFLUENCES ON INFANT BRAIN DEVELOPMENT: UNDERSTANDING THE DEVELOPMENTAL ORIGINS OF MENTAL ILLNESS - PROJECT SUMMARY DESPITE DECADES OF RESEARCH PSYCHIATRIC DISORDERS CONTINUE TO BE A LEADING SOURCE OF DISABILITY IN THE UNITED STATES AND ACROSS THE WORLD. A KEY CHALLENGE FOR THOSE SEEKING TO DEVELOP NEW THERAPEUTICS IS THAT BY THE TIME CLINICAL SYMPTOMS OF MENTAL ILLNESS ARE RECOGNIZED, MUCH OF THE UNDERLYING PATHOLOGIC BRAIN DEVELOPMENT HAS ALREADY OCCURRED AND MAY BE IRREVERSIBLE. CONSEQUENTLY, OUR BEST HOPE OF SIGNIFICANTLY IMPACTING CARE AND OUT- COMES IN THESE DEVASTATING DISORDERS IS VIA PREVENTION AND VERY EARLY INTERVENTION, WHICH OUR PROPOSED RESEARCH WILL HELP ENABLE, BY INTEGRATING GENOMICS WITH LONGITUDINAL, PEDIATRIC IMAGING DATA AND BEHAVIORAL PHENOTYPING TO BETTER UNDERSTAND THE DEVELOPMENTAL ORIGINS OF MENTAL ILLNESS. OUR CENTRAL HYPOTHESIS IS THAT GENETIC VARIANTS ASSOCIATED WITH PSYCHIATRIC DISORDERS INCREASE RISK BY INFLUENCING EARLY NEURODEVELOPMENT AND THE ESTABLISHMENT OF BRAIN CIRCUITRY. THIS HYPOTHESIS IS SUPPORTED BY SEVERAL LARGE-SCALE STUDIES WHICH PERFORMED FUNCTIONAL GENOMIC CHARACTERIZATION OF LOCI THAT CONFER RISK FOR MULTIPLE PSYCHIATRIC DISORDERS AND REVEALED ENRICHMENT FOR GENES REG- ULATING NERVOUS SYSTEM DEVELOPMENT, AS WELL AS INNOVATIVE STUDIES BY OUR GROUP IN WHICH WE 1) DISCOVERED VARIATION IN PUTATIVE RISK GENES FOR ALZHEIMER'S DISEASE AND MENTAL ILLNESS ARE ASSOCIATED WITH BRAIN CHANGES AT BIRTH, AND 2) UNCOVERED NEW GENES AND VARIANTS IMPLICATED IN BRAIN DEVELOPMENT, USING GWAS. THESE FINDINGS WERE BASED ON CROSS-SECTIONAL DATA, COLLECTED CLOSE TO BIRTH. TO MORE FULLY UNDERSTAND HOW DNA VARIANTS INFLU- ENCE BRAIN DEVELOPMENT IN INFANCY AND EARLY CHILDHOOD, AND POTENTIAL IMPLICATIONS FOR FUTURE RESEARCH AND CLINICAL CARE, LARGE, LONGITUDINAL STUDIES ARE NEEDED. OUR PROPOSED STUDY WILL MEET THIS NEED, AND TEST OUR CENTRAL HYPOTH- ESIS BY 1) HARMONIZING A RICH ARRAY OF GENETIC, NEUROIMAGING, AND BEHAVIORAL DATA ACROSS 19 LARGE AND DIVERSE INFANT AND PEDIATRIC COHORTS FROM THE U.S., EUROPE, SOUTH AFRICA, AND ASIA (N=6809, MOST WITH TWO OR MORE LONGITUDINAL BRAIN SCANS AND DEVELOPMENTALLY APPROPRIATE MEASURES OF IMPULSIVITY, ANXIETY, AND AGGRESSIVE BE- HAVIOR); 2) DETERMINING HOW COMMON GENETIC VARIANTS, INCLUDING THOSE ASSOCIATED WITH MENTAL ILLNESS, INFLUENCE DEVELOPMENTAL IMAGING PHENOTYPES (DIPS) DERIVED FROM STRUCTURAL MRI, DIFFUSION TENSOR IMAGING (DTI), AND REST- ING STATE FMRI; AND 3) IDENTIFYING RELATIONSHIPS BETWEEN GENETICALLY-INFLUENCED DIPS AND CLINICALLY-SALIENT BEHAV- IORS USING POWERFUL MULTIVARIATE ANALYSIS METHODS. OUR RESEARCH TEAM INCLUDES WORLD THOUGHT-LEADERS IN INFANT IMAGING, GENOMIC APPROACHES TO UNDERSTANDING COMPLEX TRAITS, AND BEHAVIORAL ASSESSMENT OF INFANTS AND YOUNG CHILDREN, ALL WORKING TOGETHER AS THE ORGANIZATION FOR IMAGING GENOMICS OF INFANCY (ORIGIN). WE ARE ALSO PART OF THE ENIGMA CONSORTIUM AND WILL LEVERAGE THE INTELLECTUAL RESOURCES OF THIS HIGHLY SUCCESSFUL GROUP. THE AP- PLICATION IS INNOVATIVE IN ITS FOCUS ON INFANCY AND EARLY CHILDHOOD, LONGITUDINAL DESIGN, AND IN LEVERAGING A UNIQUE GLOBAL ALLIANCE OF RESEARCHERS TO CREATE THE LARGEST-EVER IMAGING GENOMICS DATASET FOCUSED ON INFANCY AND EARLY CHILDHOOD. THE PROPOSED RESEARCH WILL HAVE A POSITIVE IMPACT BECAUSE IT WILL ENHANCE OUR FUNDAMENTAL UNDER- STANDING OF HOW GENETIC FACTORS INFLUENCE BRAIN DEVELOPMENT AND LAY THE GROUNDWORK FOR A PROMISING NEW LINE OF RESEARCH FOCUSED ON EARLY INTERVENTION IN INDIVIDUALS AT HIGH RISK FOR DEVELOPING A PSYCHIATRIC DISORDER.

PROJECT ABSTRACT - MICHIGAN STATE UNIVERSITY: THE HATCH ACT OF 1887 (REGULAR RESEARCH FUND)THE MISSION OF MSU AGBIORESEARCH IS TO ENGAGE IN INNOVATIVE, LEADING?EDGE RESEARCH THAT COMBINESSCIENTIFIC EXPERTISE WITH PRACTICAL EXPERIENCE TO GENERATE ECONOMIC PROSPERITY, SUSTAIN NATURAL RESOURCES,AND ENHANCE THE QUALITY OF LIFE IN MICHIGAN, THE NATION AND THE WORLD. AS WE OFTEN DESCRIBE AS'FUNDAMENTAL RESEARCH WITH AN INTENDED OUTCOME.' ALL OF OUR RESEARCH IS AIMED AT SOLVING PROBLEMS ORCREATING A NEW OPPORTUNITY. THE 340 PLUS RESEARCHERS ACROSS CAMPUS STRIVE TO MAINTAIN A BALANCEBETWEEN BASIC AND APPLIED RESEARCH AND RELY HEAVILY ON THE INPUT OF THEIR CONSTITUENTS IN IDENTIFYINGRESEARCH PRIORITIES. WITH HATCH FUNDING, WE WILL: INCREASE FARMERS' SUCCESS WITH PROTECTING THEENVIRONMENT, ENSURING FOOD SAFETY, REACHING NEW MARKETS, AND ADVANCING AGRICULTURE THROUGH APPLIEDRESEARCH; CONDUCT RESEARCH ON SELECTING PLANTS AND ANIMALS WITH DESIRABLE TRAITS AND ON NEW METHODS TOCOMBAT DISEASES AND PARASITES; STUDY NUTRITION AND ANIMAL MANAGEMENT SYSTEMS; DEVELOP INTEGRATEDCROP AND SOIL MANAGEMENT SYSTEMS TO MEET PRODUCTION AND ENVIRONMENTAL GOALS; ENHANCE THEPRODUCTION AND PROFITABI LITY OF SMALL?SCALE AGRICULTURE PROJECTS AND IMPROVE COMMUNITY WELLNESS; USEEDUCATIONAL PROCESSES TO FACILITATE THE INCORPORATION OF RENEWABLE ENERGY INTO HOUSEHOLDS,GOVERNMENTAL OFFICES, AND BUSINESSES; INCREASE THE CAPACITY TO DEVELOP FOREST AND AGRICULTURAL?BAS EDRENEWABLE RESOURCES IN ECOLOGICALLY AND ECONOMICALLY SUSTAINABLE WAYS

FFY-21 MICHIGAN STATE UNIVERSITY HATCH REGULAR RESEARCH FUND

THE MISSION OF MSU AGBIORESEARCH IS TO ENGAGE IN INNOVATIVE, LEADING?EDGE RESEARCH THAT COMBINES SCIENTIFIC EXPERTISE WITH PRACTICAL EXPERIENCE TO GENERATE ECONOMIC PROSPERITY, SUSTAIN NATURAL RESOURCES, AND ENHANCE THE QUALITY OF LIFE IN MICHIGAN, THE NATION AND THE WORLD. AS WE OFTEN DESCRIBE AS 'FUNDAMENTAL RESEARCH WITH AN INTENDED OUTCOME.' ALL OF OUR RESEARCH IS AIMED AT SOLVING PROBLEMS OR CREATING A NEW OPPORTUNITY. THE 340 PLUS RESEARCHERS ACROSS CAMPUS STRIVE TO MAINTAIN A BALANCE BETWEEN BASIC AND APPLIED RESEARCH AND RELY HEAVILY ON THE INPUT OF THEIR CONSTITUENTS IN IDENTIFYING RESEARCH PRIORITIES. WITH HATCH FUNDING, WE WILL: INCREASE FARMERS' SUCCESS WITH PROTECTING THE ENVIRONMENT, ENSURING FOOD SAFETY, REACHING NEW MARKETS, AND ADVANCING AGRICULTURE THROUGH APPLIED RESEARCH; CONDUCT RESEARCH ON SELECTING PLANTS AND ANIMALS WITH DESIRABLE TRAITS AND ON NEW METHODS TO COMBAT DISEASES AND PARASITES; STUDY NUTRITION AND ANIMAL MANAGEMENT SYSTEMS; DEVELOP INTEGRATED CROP AND SOIL MANAGEMENT SYSTEMS TO MEET PRODUCTION AND ENVIRONMENTAL GOALS; ENHANCE THE PRODUCTION AND PROFITABILITY OF SMALL?SCALE AGRICULTURE PROJECTS AND IMPROVE COMMUNITY WELLNESS; USE EDUCATIONAL PROCESSES TO FACILITATE THE INCORPORATION OF RENEWABLE ENERGY INTO HOUSEHOLDS, GOVERNMENTAL OFFICES, AND BUSINESSES; INCREASE THE CAPACITY TO DEVELOP FOREST AND AGRICULTURAL?BASED RENEWABLE RESOURCES IN ECOLOGICALLY AND ECONOMICALLY SUSTAINABLE WAYS

CONNECTING NITROGEN TRANSFORMATIONS MEDIATED BY THE RHIZOSPHERE MICROBIOME TO PERENNIAL CROPPING SYSTEM PRODUCTIVITY IN MARGINAL LANDS

NUCLEAR STRUCTURE STUDIES AT THE LIMITS OF STABILITY

CENTER FOR WOMEN'S HEALTH AND REPRODUCTION

ELUCIDATING THE GENETIC ARCHITECTURE OF PROVITAMIN A AND VITAMIN E BIOSYNTHESIS IN SEED

RESEARCH-PGR: HOW DO PLANTS PRODUCE SO MANY DIVERSE METABOLITES: A COMPUTATIONAL AND EXPERIMENTAL COMPARATIVE GENOMICS INVESTIGATION IN THE SOLANACE

MICHIGAN STATE UNIVERSITY AGBIORESEARCH PROGRAMS FOR FFY-14

DEVELOPMENT AND APPLICATION OF HIGH EFFICIENCY THERMOELECTRIC MATERIALS FOR POWER GENERATION

MICHIGAN STATE UNIVERSITY AGBIORESEARCH HATCH PROGRAMS FOR FFY-18

MICHIGAN STATE UNIVERSITY AGBIORESEARCH HATCH PROGRAMS FOR FY-17

MICHIGAN STATE UNIVERSITY AGBIORESEARCH PROGRAMS FOR FFY-12

11.557 AMERICAN RECOVERY AND REINVESTMENT ACT - SBA - THE BROADBAND ADOPTION THROUGH EDUCATION AND E-ENTREPRENEURSHIP IN MICHIGAN'S URBAN CORES

DIGITAL AGRICULTURE TO ENHANCE THE SUSTAINABILITY OF US CROPING SYSTEMS

**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** FIRE BLIGHT IS A DEVASTATING DISEASE OF APPLE AND PEAR THAT THREATENS SUSTAINABLE PRODUCTION OF THESE CROPS IN THE UNITED STATES. THE SPECTRE OF FIRE BLIGHT AS A RE-EMERGING DISEASE OF HIGH SIGNIFICANCE IS DUE TO TWO MAIN ISSUES: (I) ALMOST ALL NEW COMMERCIALLY-ACCEPTABLE CULTIVARS THAT ARE DESIRED BY CONSUMERS ARE HIGHLY SUSCEPTIBLE TO FIRE BLIGHT, AND (II) THE EVOLUTION AND WIDE DISTRIBUTION OF BACTERICIDE RESISTANCE IN THE FIRE BLIGHT PATHOGEN ERWINIA AMYLOVORA HAS IMPACTED THE NUMBER OF EFFICACIOUS TOOLS FOR DISEASE MANAGEMENT. CRITICAL NEEDS AT THE RESEARCH AND EXTENSION LEVEL ADDRESSING FIRE BLIGHT INCLUDE A NEED FOR IMPROVED MANAGEMENT OPTIONS AND STRATEGIES THAT ARE VALIDATED ON A NATIONAL SCALE, DETECTION METHODOLOGIES THAT ENABLE THE RAPID DETERMINATION OF HIGHLY-VIRULENT E. AMYLOVORA STRAINS WITHIN ORCHARD POPULATIONS, AND ECONOMIC ANALYSES THAT WILL GUIDE GROWER DEPLOYMENT OF OPTIMIZED MANAGEMENT STRATEGIES THAT MAXIMIZE RETURNS. OUR COMPREHENSIVE, NATIONAL PROJECT WILL DIRECTLY TARGET THE PATHOGEN WITH REIMAGINED DISEASE CONTROL STRATEGIES, LAY THE GROUNDWORK FOR FUTURE DISEASE-TOLERANT APPLE CULTIVARS BY DEVELOPING PRE-BREEDING LINES WITH FIRE BLIGHT RESISTANCE AND SUPERIOR FRUIT QUALITY TRAITS, AND PROVIDE GROWERS WITH A THOROUGH ECONOMIC ANALYSIS OF THE COSTS AND BENEFITS OF NEWLY DEVELOPED SYSTEMS.

MSUE PROGRAMS, FFY-11

PESTICIDE USE AND MARKERS OF ADRD NEURODEGENERATION AMONG US FARMERS - ABSTRACT MANY PESTICIDES ARE NEUROTOXIC, AND HIGH EXPOSURES MAY HAVE LONG-TERM NEURODEGENERATIVE CONSEQUENCES. HOWEVER, EMPIRICAL EVIDENCE ON THE ASSOCIATION BETWEEN PESTICIDES AND ALZHEIMER’S DISEASE AND RELATED DEMENTIAS (ADRD) IS PRELIMINARY AND INCONSISTENT. THIS PROJECT WILL IDENTIFY LINKS BETWEEN PESTICIDE EXPOSURE AND MARKERS ACROSS THE ADRD NEURODEGENERATION CONTINUUM, FROM PRECLINICAL BIOMARKERS TO CLINICAL DIAGNOSIS. THE STUDY WILL BE CONDUCTED AMONG RURAL FARMERS, THE GROUP WITH PARTICULARLY HIGH PESTICIDE EXPOSURE. THE CENTRAL HYPOTHESIS IS THAT HIGH PESTICIDE EXPOSURE WILL INCREASE THE RISK OF ADRD NEURODEGENERATION. THIS PROJECT WILL LEVERAGE 30 YEARS OF ENVIRONMENTAL HEALTH DATA FROM THE AGRICULTURAL HEALTH STUDY (AHS) WITH LONGITUDINAL COGNITIVE ASSESSMENTS IN AN AHS SUB-COHORT - THE PESTICIDES AND SENSE OF SMELL (PASS) STUDY. THE CENTRAL HYPOTHESIS WILL BE TESTED BY PURSUING FOUR SPECIFIC AIMS: 1) IDENTIFY PESTICIDES THAT ARE ASSOCIATED WITH INCIDENT ADRD DIAGNOSIS USING 30 YEARS OF COMPREHENSIVE AHS COHORT-WIDE MEDICARE-LINKAGE DATA; AND IN THE AHS- PASS SUB-COHORT, 2) IDENTIFY THE ASSOCIATION BETWEEN PESTICIDE EXPOSURES AND PLASMA BIOMARKERS OF ADRD; 3) DETERMINE THE ASSOCIATION OF PESTICIDE EXPOSURES WITH OLFACTORY LOSS, A HIGHLY SENSITIVE AND EASILY ASSESSABLE MARKER OF EARLY ADRD DEVELOPMENT, AND 4) DETERMINE THE ASSOCIATION BETWEEN PESTICIDE EXPOSURES AND COGNITIVE DECLINE AND IMPAIRMENT. THE AHS ENROLLED 52,394 U.S. FARMERS AND IS ONE OF THE WORLD’S LARGEST AND BEST-CHARACTERIZED AGRICULTURAL COHORTS, WITH EXTENSIVE LONGITUDINAL ASSESSMENTS OF PESTICIDE EXPOSURES OVER FARMERS’ PRIME WORKING YEARS. THE ONGOING PASS STUDY FURTHER LAID A SOLID FOUNDATION FOR LEVERAGING THE RICH AHS ENVIRONMENTAL HEALTH DATA FOR ADRD RESEARCH BY ESTABLISHING A SUB-COHORT OF 2,545 AHS FARMERS WITH COGNITIVE, OLFACTION, AND MOTOR ASSESSMENTS. THE PROPOSED RESEARCH WILL INVOLVE LONGITUDINALLY FOLLOWING PASS PARTICIPANTS, COLLECTING BLOOD SAMPLES, AND ASSESSING OLFACTION, GUSTATION, MOTOR, AND COGNITIVE FUNCTION OVER FOUR TIME POINTS. THE STUDY WILL BE LIMITED TO PASS PARTICIPANTS AGED 50-79 AT ENROLLMENT TO TARGET WINDOWS OF PRECLINICAL AND PRODROMAL NEURODEGENERATION WHEN DISEASE PREVENTION IS MORE FEASIBLE. THE SCIENTIFIC RIGOR OF THIS PROJECT IS ENSURED BY STATE-OF-THE-SCIENCE PESTICIDE EXPOSURE ASSESSMENTS IN AN OCCUPATIONALLY EXPOSED POPULATION, LONGITUDINAL OUTCOME ASSESSMENTS ACROSS THE ADRD CONTINUUM, CAREFULLY PLANNED STATISTICAL ANALYSES, AND AN EXPERIENCED MULTIDISCIPLINARY AND MULTI-INSTITUTIONAL RESEARCH TEAM. INNOVATION AND SIGNIFICANCE: THIS PROJECT WILL ADVANCE OUR KNOWLEDGE OF THE ASSOCIATION BETWEEN PESTICIDE EXPOSURES AND ADRD BY LEVERAGING 30 YEARS OF EXTENSIVE DATA FROM A WELL-CHARACTERIZED FARMING POPULATION. THE PROJECT WILL BRING NEW INSIGHTS INTO THE ROLES THAT A CLASS OF UBIQUITOUS BUT POORLY STUDIED ENVIRONMENTAL EXPOSURES PLAY IN VARIOUS STAGES OF ADRD DEVELOPMENT, CRITICALLY INFORMING MECHANISTIC RESEARCH AND PREVENTIVE STRATEGIES. THIS PROJECT WILL ALSO ESTABLISH A UNIQUE ADRD RESEARCH RESOURCE IN RARELY STUDIED RURAL POPULATIONS.

EVOLUTION OF SPECIALIZED METABOLITE BIOSYNTHETIC PATHWAYS IN THE LAMIACEAE: SOURCES OF CHEMICAL DIVERSITY FOR MOLECULES ESSENTIAL FOR HUMAN USE AND P

GLOBAL CENTERS: INTERNATIONAL RESEARCH CENTER FOR ENHANCING PLANT RESILIENCE -THIS AWARD IS FUNDED BY NSF GLOBAL CENTERS PROGRAM, AN INNOVATIVE PARTNERSHIP WITH FUNDING AGENCIES IN CANADA, FINLAND, JAPAN, REPUBLIC OF KOREA, AND THE UNITED KINGDOM, TO JOINTLY SUPPORT USE-INSPIRED RESEARCH ADDRESSING GLOBAL CHALLENGES THROUGH THE BIOECONOMY. THESE PARTNERSHIPS LEVERAGE RESOURCES TO TACKLE CHALLENGES AT A LARGER SCALE THAN WOULD BE POSSIBLE FOR ONE FUNDING AGENCY ALONE. THIS CENTER IS JOINTLY SUPPORTED BY NSF, THE NATURAL SCIENCES AND ENGINEERING RESEARCH COUNCIL AND THE SOCIAL SCIENCES AND HUMANITIES RESEARCH COUNCIL OF CANADA, JAPAN SCIENCE AND TECHNOLOGY AGENCY, THE NATIONAL RESEARCH FOUNDATION OF KOREA, AND UK RESEARCH AND INNOVATION. THE INTERNATIONAL RESEARCH CENTER FOR ENHANCING PLANT RESILIENCE ADDRESSES THE CRITICAL CHALLENGE OF STABILIZING GLOBAL FOOD PRODUCTION AMID UNPREDICTABLE WEATHER PATTERNS. IT BRINGS TOGETHER EXPERTS FROM THE UNITED STATES, CANADA, JAPAN, REPUBLIC OF KOREA, AND THE UNITED KINGDOM, TO EXPLORE SUSTAINABLE SOLUTIONS FOR AGRICULTURE. BY DISCOVERING AND HARNESSING NATURAL PRODUCTS FROM PLANTS AND MICROBES, IT AIMS AT ENHANCING PLANT AND SOIL HEALTH. THE GOAL IS TO ENSURE CROP PRODUCTIVITY DESPITE INCREASING ENVIRONMENTAL STRESSORS. BY CREATING NATURAL SOLUTIONS TO STABILIZE CROP PRODUCTIVITY, THE CENTER ADDRESSES URGENT AGRICULTURAL PROBLEMS. IT REDUCES RELIANCE ON NON-SUSTAINABLE PRACTICES LIKE SYNTHETIC FERTILIZERS AND EXTENSIVE IRRIGATION. IT ENGAGES INDUSTRY AND AGRICULTURAL STAKEHOLDERS. THIS ENSURES THAT THE DEVELOPED SOLUTIONS ARE PRACTICAL, SCALABLE, AND ADOPTED WIDELY. THE INTERNATIONAL COLLABORATION ALSO FOSTERS MULTIDISCIPLINARY KNOWLEDGE EXCHANGE AND SKILL DEVELOPMENT ACROSS BORDERS. IT STRENGTHENS GLOBAL SCIENTIFIC CAPABILITIES. IT PLAYS A PIVOTAL ROLE IN TRAINING THE NEXT GENERATION OF SCIENTISTS AND LEADERS IN SUSTAINABLE AGRICULTURE. A PARTICULAR FOCUS ON PUBLIC ENGAGEMENT AND TECHNOLOGY ADOPTION AIMS TO BUILD TRUST AND FACILITATE THE WIDESPREAD IMPLEMENTATION OF SUSTAINABLE AGRICULTURAL PRACTICES. THIS EFFORT CONTRIBUTES TO THE BROAD BIOECONOMY AND SOCIETAL WELL-BEING. THE CENTER HARNESSES THE NATURAL CHEMICAL DIVERSITY HARBORED IN PLANTS AND MICROBES. IT GENERATES GREEN CHEMISTRY SOLUTIONS TO ENHANCE CROP RESILIENCE AGAINST STRESSES LIKE DROUGHT AND HEAT WAVES, MINIMIZE EXTERNAL FERTILIZATION, AND PROTECT CROPS AGAINST INCREASING PEST AND PATHOGEN LOAD. THE RESEARCH INVOLVES A DETAILED EXPLORATION OF PLANT AND MICROBIAL METABOLITES THAT CAN IMPROVE CROP RESILIENCE. THE TEAM SAMPLES, ANNOTATES, AND SYNTHESIZES KEY METABOLITES, USING ADVANCED GENOMICS, AI-BASED STRATEGIES, AND SYNTHETIC BIOLOGY. THE RESEARCH PIPELINE INCLUDES IDENTIFYING BIOSYNTHETIC PATHWAYS, VALIDATING BIOACTIVITY THROUGH LAB AND FIELD TESTING, AND ASSESSING THE ENVIRONMENTAL AND ANIMAL TOXICITY OF THESE COMPOUNDS. BY INTEGRATING INTERNATIONAL EXPERTISE AND RESOURCES, THE CENTER DEVELOPS NEW, NATURAL AGRICULTURAL PRODUCTS THAT ENHANCE CROP RESILIENCE, REDUCE DEPENDENCY ON NON-SUSTAINABLE FARMING PRACTICES, AND SUPPORT GLOBAL FOOD SECURITY. THIS TECHNICAL WORK IS COMPLEMENTED BY RIGOROUS PUBLIC ENGAGEMENT AND OUTREACH EFFORTS, ENSURING THAT ITS OUTCOMES ARE ACCESSIBLE AND BENEFICIAL TO SOCIETY AT LARGE. THE CENTER ESTABLISHES AN INTERNATIONAL TRAINING PROGRAM TO PROMOTE CROSS-LAB, INSTITUTE, AND COUNTRY COLLABORATION, ENHANCING GLOBAL KNOWLEDGE AND WORKFORCE DEVELOPMENT. THE OVERARCHING GOAL IS TO TRANSITION TO THE EARLY OPERATIONAL STAGE WITH CONTRACTS FROM GOVERNMENTS, ACADEMIC INSTITUTIONS, AND INDUSTRY PARTNERS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

NSF CONVERGENCE ACCELERATOR TRACK H: AN INCLUSIVE, HUMAN-CENTERED, AND CONVERGENT FRAMEWORK FOR TRANSFORMING VOICE AI ACCESSIBILITY FOR PEOPLE WHO STUTTER -IN A SOCIETY INCREASINGLY NAVIGATED THROUGH VOICE-ACTIVATED ARTIFICIAL INTELLIGENCE (VOICE AI), PEOPLE WHO STUTTER-REPRESENTING OVER 3 MILLION AMERICANS AND ROUGHLY 80 MILLION INDIVIDUALS GLOBALLY-FACE A MAJOR BARRIER: EXISTING VOICE AI TECHNOLOGIES FREQUENTLY FAIL TO RECOGNIZE DISFLUENT SPEECH PATTERNS, LEADING TO A CASCADE OF DISADVANTAGES IN ACCESSIBILITY, EMPLOYMENT, AND SOCIETAL INCLUSION. THIS PROJECT ADDRESSES THIS PRESSING CONCERN BY TRANSFORMING VOICE AI INTO AN INCLUSIVE PLATFORM THAT COMPREHENDS AND RESPECTS THE DIVERSITY OF HUMAN SPEECH. BY REIMAGINING VOICE AI THROUGH THE LENS OF THOSE WHO STUTTER, THIS PROJECT NOT ONLY CHAMPIONS THE CAUSE OF A HISTORICALLY MARGINALIZED GROUP; IT ALSO ENHANCES VOICE TECHNOLOGY FOR EVERYONE, BECAUSE ALL SPEAKERS ARE DISFLUENT TO SOME EXTENT. ALIGNING WITH NSF'S MISSION, THESE ADVANCEMENTS PROMOTE SCIENTIFIC PROGRESS, FOSTER NATIONAL WELFARE, AND CONTRIBUTE TO A MORE INCLUSIVE SOCIETY BY EMBRACING AND UNDERSTANDING DIVERSE SPEECH PATTERNS. OPERATIONALIZING A HUMAN-CENTERED AND CONVERGENT PARADIGM, THIS PROJECT SETS OUT TO ACCOMPLISH FOUR KEY SYNERGISTIC OBJECTIVES: (1) CULTIVATING A MULTIDISCIPLINARY AND MULTI-SECTORAL NETWORK OF STAKEHOLDERS TO STEER IMPACTFUL OUTCOMES, (2) ARTICULATING A HOLISTIC VISION FOR USER-CENTRIC VOICE AI, (3) DESIGNING A COMPREHENSIVE SET OF ADAPTIVE VOICE AI SOLUTIONS AND ESTABLISHING A TESTBED FOR THEIR EVALUATION, AND (4) DRAFTING GUIDELINES FOR MANAGING ASSOCIATED VOICE AI RISKS. HARNESSING CUTTING-EDGE AI TECHNOLOGY, THE PROJECT WILL PIONEER INCLUSIVE TRAINING AND TEST DATASETS AS WELL AS ANNOTATION FOR ACCESSIBLE AUTOMATIC SPEECH RECOGNITION (ASR) AND DEVELOP ADVANCED ASR DEEP LEARNING MODELS. THE ADOPTED METHODOLOGY ENCOMPASSES ITERATIVE RESEARCH, CONTINUOUS ENGAGEMENT WITH END-USERS TO PINPOINT EXISTING AND FUTURE BARRIERS, AND STRINGENT EVALUATIONS OF SOLUTION EFFICACY. THE OVERARCHING GOAL IS TO TRANSFORM VOICE AI, THROUGH AN ECOSYSTEM THAT IS ACCESSIBLE AND RESPONSIVE TO ALL, THEREBY ENSURING THAT EVERY VOICE IS HEARD. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

EVALUATING MICHIGAN'S EARLY LITERACY LAW: IMPACTS, IMPLEMENTATION AND IMPROVING STATE CAPACITY

PESTICIDES, OLFACTION, AND NEURODEGENERATION AMONG US FARMERS

NATURAL SCIENCE TRANSFER SCHOLARS

NATURAL SCIENCE TRANSFER SCHOLARS: NATURAL SCIENCE FOUNDATIONS FOR INNOVATION IN THE DATA-DRIVEN ECONOMY -THIS PROJECT WILL CONTRIBUTE TO MEETING THE NATIONAL NEED FOR WELL-EDUCATED SCIENTISTS, MATHEMATICIANS, ENGINEERS, AND TECHNICIANS BY SUPPORTING THE RETENTION AND GRADUATION OF HIGH-ACHIEVING, LOW-INCOME STUDENTS WITH DEMONSTRATED FINANCIAL NEED AT MICHIGAN STATE UNIVERSITY (MSU), MOTT COMMUNITY COLLEGE (MCC; FLINT, MI), AND WASHTENAW COMMUNITY COLLEGE (WCC; ANN ARBOR, MI). OVER ITS SIX-YEAR DURATION, THIS PROJECT WILL FUND SCHOLARSHIPS TO 50 UNIQUE FULL-TIME STUDENTS AT MCC AND 75 UNIQUE FULL-TIME STUDENTS AT WCC WHO ARE PURSUING ASSOCIATE?S DEGREES IN STEM FIELDS WITH THE INTENT TO TRANSFER TO A FOUR-YEAR INSTITUTION TO COMPLETE A BACHELOR?S DEGREE IN A STEM FIELD. THIS PROJECT WILL ALSO FUND 32 UNIQUE FULL-TIME STUDENTS AT MSU WHO HAVE TRANSFERRED WITH 40 OR MORE CREDITS FROM A MICHIGAN COMMUNITY COLLEGE (CC) TO COMPLETE A BACHELOR?S DEGREE IN THE BIOLOGICAL, MATHEMATICAL, OR PHYSICAL SCIENCES. FIRST-YEAR STUDENTS AT MCC AND WCC WILL RECEIVE UP TO TWO YEARS OF SCHOLARSHIP SUPPORT, AND STUDENTS TRANSFERRING TO MSU WILL RECEIVE UP TO THREE YEARS OF SCHOLARSHIP SUPPORT. THIS PROJECT WILL PROMOTE THE SUCCESSFUL TRANSFER OF ACADEMICALLY TALENTED, LOW-INCOME STUDENTS FROM CCS TO UNIVERSITIES THROUGH GRADUATION WITH STEM DEGREES BY PROVIDING COMPREHENSIVE ACADEMIC AND PSYCHOSOCIAL SUPPORT TO PARTICIPATING STUDENTS PRE AND POST TRANSFER. TO SUPPORT STUDENTS IN THE TRANSITION FROM CC TO THE UNIVERSITY, THE PROJECT WILL ALSO PROVIDE PEER MENTORING SUPPORT AND UNDERGRADUATE RESEARCH OPPORTUNITIES. THE PROJECT WILL ALSO AUGMENT THE TRAINING OF LOW-INCOME CC STUDENTS IN THE NATURAL SCIENCES BY INCORPORATING OPPORTUNITIES TO BUILD CAPACITY TO APPLY THE METHODS OF DATA SCIENCE TO SOLVE PROBLEMS IN THEIR DISCIPLINARY AREA OF STUDY, ENHANCING THEIR PREPARATION TO MEET NEW CHALLENGES AND INNOVATE IN THE DATA-DRIVEN ECONOMY. BUILDING A SUSTAINABLE RECRUITMENT EFFORT TO ATTRACT LOW-INCOME STUDENTS TO STEM DEGREE PROGRAMS THROUGH CCS IS CRITICAL TO MEETING STEM WORKFORCE NEEDS IN MICHIGAN. THIS WORK WILL CONTINUE TO STRENGTHEN THE EXISTING PARTNERSHIP TO CREATE A CLEAR AND TRANSPARENT PATHWAY FROM MCC AND WCC TO A STEM BACHELOR?S DEGREE AT MSU. THIS PROJECT WILL ALSO EXPLORE AND ESTABLISH THE ACADEMIC, ADMINISTRATIVE, AND CULTURAL STRUCTURES EXTENDING ACROSS INSTITUTIONAL BOUNDARIES THAT PRODUCE EFFECTIVE MOVEMENT OF STUDENTS SEEKING TO COMPLETE A BACHELOR'S DEGREE IN STEM. THE OVERALL GOAL OF THIS PROJECT IS TO INCREASE STEM DEGREE COMPLETION OF LOW-INCOME, HIGH-ACHIEVING UNDERGRADUATES WITH DEMONSTRATED FINANCIAL NEED THROUGH THE SUPPORT OF THE MULTI-INSTITUTION CONSORTIUM. THIS CONSORTIUM WILL EXPAND EFFORTS TO RECRUIT TALENTED LOW-INCOME STUDENTS TO THE STEM SCHOLARS PROGRAM AT MCC AND WCC AND TO BACCALAUREATE PROGRAMS IN THE NATURAL SCIENCES AT MSU FROM CCS IN MICHIGAN AND WILL INTEGRATE SUPPORT STRUCTURES AT THE THREE INSTITUTIONS. THE PROJECT ALSO AIMS TO ENHANCE THE CAPACITY OF STUDENTS TO INNOVATE IN THE SCIENCE AND TECHNOLOGY SECTOR AND INCREASE THEIR COMPETITIVENESS FOR WELL-PAYING CAREERS BY OFFERING OPPORTUNITIES TO ENGAGE IN DATA SCIENCE AND APP DEVELOPMENT. ONE MAJOR GOAL OF THIS PROJECT IS TO ENHANCE THE PATH FOR THE TRANSFER STUDENT POPULATION TO A STEM BACHELOR?S DEGREE TO BUILD AND DIVERSIFY THE STEM WORKFORCE. RESEARCH WILL BE CONDUCTED TO UNDERSTAND WHICH SUPPORTS AND EXPERIENCES HAVE SIGNIFICANT IMPACTS ON STUDENTS' SUCCESSFUL TRANSFER AND COMPLETION OF A STEM BACHELOR?S DEGREE. THE EMBEDDED RESEARCH COMPONENT OF THIS PROJECT WILL ADDRESS THE FOLLOWING RESEARCH QUESTIONS (RQS) THAT FOCUS ON STUDENT SELF-EFFICACY (SE) AND SCIENCE IDENTITY: ? RQ1: WHAT KINDS OF STRUCTURAL SUPPORTS AT THE CC IMPACT A STUDENT?S TRANSFER SE (SELF-EFFICACY TO TRANSFER FROM A CC TO A BACCALAUREATE INSTITUTION) AND DEGREE SE (SELF-EFFICACY TO GRADUATE WITH A BACHELOR?S DEGREE IN STEM)? ? RQ2: WHAT EFFECT DO THE TRANSITIONAL SUPPORTS AT THE BACCALAUREATE-GRANTING INSTITUTION HAVE ON INCOMING TRANSFER STUDENTS? DEGREE SE AND SCIENCE IDENTITY? ? RQ3: ONCE A TRANSFER STUDENT HAS SUCCESSFULLY TRANSITIONED INTO THE UNIVERSITY, WHAT ARE THE KEY EXPERIENCES THEY LEVERAGE TO MAINTAIN THEIR DEGREE SE AND SCIENCE IDENTITY? SINCE SE AND SCIENCE IDENTITY CHANGE OVER TIME, THE RESEARCH WILL EMPLOY A MIXED-METHODS APPROACH USING A NOVEL EXPERIENCE SAMPLING METHOD (ESM) TO MEASURE SE IN-THE-MOMENT PARTNERED WITH DAILY JOURNAL REFLECTIONS WHERE STUDENTS SHARE MORE ABOUT SPECIFIC EVENTS. ANTICIPATED PROJECT OUTCOMES INCLUDE INCREASED NUMBERS OF LOW-INCOME, ACADEMICALLY-TALENTED STUDENTS TRANSFERRING FROM MCC AND WCC TO 4-YEAR INSTITUTIONS TO PURSUE STEM BACHELOR?S DEGREES AND HIGH STEM DEGREE COMPLETION RATES FOR STUDENTS AWARDED SCHOLARSHIPS UPON TRANSFERRING TO MSU FROM A MICHIGAN CC. KNOWLEDGE GENERATED BY THE RESEARCH COMPONENT OF THIS PROJECT WILL OFFER A ROADMAP TO DEVELOPING PROGRAMMATIC SUPPORTS TO BUILD CC AND TRANSFER STUDENT SE AND SCIENCE IDENTITY FOR USE BY OTHER INSTITUTIONS. THE CENTER FOR EDUCATION DESIGN, EVALUATION, AND RESEARCH (UNIVERSITY OF MICHIGAN) WILL PROVIDE FORMATIVE AND SUMMATIVE EVALUATION OF PROCESS AND OUTCOMES USING QUALITATIVE AND QUANTITATIVE METHODS TO ASSESS: 1) PROGRAM IMPACT THROUGH COMPARISON WITH MATCHED CONTROL GROUPS OF TRANSFER AND NATIVE STUDENTS, 2) STUDENT PERCEPTIONS OF DATA-DRIVEN SCIENCE AS A PROMISING PATHWAY 3) PROGRESS TOWARD BENCHMARKS, AND 4) POST-GRADUATION OUTCOMES. EXTERNAL EVALUATION WILL ALSO DOCUMENT PROJECT ACTIVITIES AND PARTICIPATION, IMPLEMENTATION STRATEGIES, AND CONTEXTUAL FACTORS AND IDENTIFY BEST PRACTICES. BEST PRACTICES AND OUTCOME DATA WILL BE SHARED WITH S-STEM COMMUNITIES PROMOTING TRANSFER STUDENT SUCCESS. DISSEMINATION OF RESEARCH RESULTS TO THE BROADER STEM EDUCATION RESEARCH COMMUNITY WILL OCCUR THROUGH RESEARCH PRESENTATIONS AND PUBLICATIONS FOR COMMUNITIES SUCH AS THE COUNCIL FOR THE STUDY OF COMMUNITY COLLEGES, THE NATIONAL ASSOCIATION FOR RESEARCH IN SCIENCE TEACHING, AND THE PHYSICS EDUCATION RESEARCH COMMUNITY. THIS PROJECT IS FUNDED BY NSF?S SCHOLARSHIPS IN SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS PROGRAM, WHICH SEEKS TO INCREASE THE NUMBER OF LOW-INCOME ACADEMICALLY TALENTED STUDENTS WITH DEMONSTRATED FINANCIAL NEED WHO EARN DEGREES IN STEM FIELDS. IT ALSO AIMS TO IMPROVE THE EDUCATION OF FUTURE STEM WORKERS, AND TO GENERATE KNOWLEDGE ABOUT ACADEMIC SUCCESS, RETENTION, TRANSFER, GRADUATION, AND ACADEMIC/CAREER PATHWAYS OF LOW-INCOME STUDENTS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

THE ROSE SCALE-UP STUDY: INFORMING A DECISION ABOUT ROSE AS UNIVERSAL POSTPARTUM DEPRESSION PREVENTION - PROJECT SUMMARY/ABSTRACT POSTPARTUM DEPRESSION (PPD) IS A COMMON AND IMPACTFUL PUBLIC HEALTH PROBLEM, WHICH CAN HAVE SEVERE AND LASTING CONSEQUENCES FOR THE MOTHER AND INFANT, AND SOMETIMES THE ENTIRE FAMILY. THE REACH OUT, STAND STRONG, ESSENTIALS FOR NEW MOTHERS (ROSE) PROGRAM IS AN EVIDENCE-BASED INTERVENTION THAT PREVENTS HALF OF CASES OF POSTPARTUM DEPRESSION AND WAS ONE OF TWO INTERVENTIONS RECOMMENDED BY THE US PREVENTIVE SERVICES TASK FORCE IN 2019. ALL EFFECTIVENESS TRIALS OF ROSE AND OF THE OTHER RECOMMENDED PPD PREVENTION INTERVENTION INCLUDED ONLY LOW-INCOME WOMEN A SINGLE RISK FACTOR THAT DOUBLES INCIDENCE OF PPD. THUS, THE EXISTING EVIDENCE BASE FOR PPD PREVENTION CONSISTS PRIMARILY OF WOMEN AT INCREASED RISK FOR PPD. BASED ON DATA FROM THE PIS’ CURRENT IMPLEMENTATION STUDY OF ROSE (R01 MH114883), MANY HEALTHCARE AND COMMUNITY AGENCIES IN THIS IMPLEMENTATION TRIAL (78%) FIND IT IS MORE FEASIBLE FOR THEM TO PROVIDE OR OFFER ROSE TO EVERY WOMAN AS PART OF THEIR STANDARD WORK FLOW (I.E., PROVIDE IT AS UNIVERSAL PREVENTION), THAN IT IS TO CREATE A SCREENING AND REFERRAL PROCESS FOR AT RISK WOMEN (I.E., AN INDICATED OR SELECTIVE PREVENTION APPROACH). IN ADDITION TO BEING MORE FEASIBLE FOR AGENCIES, UNIVERSAL PREVENTION MAY ALSO BE ADVANTAGEOUS BECAUSE THE COST OF A SCREENING FALSE NEGATIVE (RESULTING IN A PREVENTABLE CASE OF PPD; $32,000) FAR EXCEEDS THE COST OF ROSE DELIVERY ($50-$300/WOMAN). EFFECTIVENESS OF ROSE AMONG LOW-INCOME WOMEN AT RISK FOR PPD IS KNOWN (ROSE PREVENTS ~50% OF PPD CASES). TO INFORM A RECOMMENDATION ABOUT USING ROSE AS UNIVERSAL VS. SELECTIVE OR INDICATED PREVENTION, WE NEED TO DETERMINE THE EFFECTIVENESS OF ROSE AMONG GENERAL POPULATIONS OF WOMEN, INCLUDING WOMEN SCREENING NEGATIVE FOR PPD RISK (DEFINED IN VARIOUS WAYS). THUS, THIS PROJECT WILL ASSESS ROSE EFFECTIVENESS ACROSS PPD RISK LEVELS AND ACROSS PREVENTION APPROACHES IN A SAMPLE OF 2,320 WOMEN FROM A LARGE REGIONAL HEALTH SYSTEM (BASED IN DETROIT, MI). EACH PROPOSED AIM GATHERS A PIECE OF INFORMATION MISSING THAT IS NEEDED TO GUIDE DECISION-MAKING ABOUT ROSE AS UNIVERSAL PREVENTION. WE WILL ASSESS ROSE AS UNIVERSAL, SELECTIVE, AND INDICATED PREVENTION IN TERMS OF: (1) ROSE EFFECTIVENESS RELATIVE TO A CONTROL FOR EACH PREVENTION APPROACH IN PREVENTING PPD AND IMPROVING FUNCTIONING; (2) COST- OUTCOME, (3) EQUITY, AND (4) SCALABILITY OF EACH PREVENTION APPROACH; AND (5) MECHANISMS OF ROSE EFFECTS ACROSS PPD RISK LEVELS. WE WILL INTEGRATE RESULTS TO ADVISE ABOUT ROSE AS UNIVERSAL PREVENTION. THIS DEFINITIVE PPD PREVENTION TRIAL WILL SHOW HOW BEST TO GET AN EVIDENCE-BASED PROGRAM TO THOSE WHO NEED IT IN SETTINGS WHERE THEY RECEIVE PERINATAL CARE BY ADDRESSING A PRAGMATIC AND NOVEL QUESTION (SHOULD ROSE BE UNIVERSAL PREVENTION?) AND BY EXAMINING EQUITY AND COST-OUTCOME OF UNIVERSAL VS. OTHER PREVENTION APPROACHES.

POST-DOCTORAL RESEARCH FELLOWSHIPS

RESEARCH-PGR: ELUCIDATING MAIZE GENE REGULATORY NETWORKS TO ACCELERATE TRANSLATIONAL GENOMICS

GRADUATE RESEARCH FELLOWSHIP PROGRAM

LTER: KBS - ECOLOGICAL AND SOCIAL MECHANISMS OF RESILIENCE IN AGROECOSYSTEMS -SINCE 1989, SCIENTISTS AT THE KELLOGG BIOLOGICAL STATION LONG-TERM ECOLOGICAL RESEARCH PROGRAM HAVE BEEN STUDYING THE ECOLOGY OF AGRICULTURAL SYSTEMS. THIS RESEARCH WOULD EXTEND THAT RESEARCH TO 40 YEARS WHILE ADDING TO OUR KNOWLEDGE OF HOW PLANTS, INSECTS, MICROBES, SOILS, AND CLIMATE INTERACT TO SHAPE AGRICULTURAL LANDSCAPES. IMPORTANTLY, IN THE US MIDWEST WHERE CORN AND SOY ROW CROPS PREDOMINATE, FARMERS INCREASINGLY MUST DEAL WITH WARMER TEMPERATURES AND MORE FREQUENT DROUGHTS. THIS PROJECT WILL STUDY HOW DIFFERENT FARMING AND CONSERVATION PRACTICES AFFECT AGRICULTURE?S ABILITY TO RECOVER FROM THESE EVENTS. THE PAST THREE DECADES OF RESEARCH HAS SHOWN THAT SOME PRACTICES HELP CROPS RECOVER FROM EXTREME WEATHER BETTER THAN OTHERS. FOR EXAMPLE, NO-TILL FARMING AND THE PLANTING OF COVER CROPS BUILDS SOIL HEALTH, LEADING TO MORE STABLE CROP YIELDS THROUGH DROUGHT. THIS LONG TERM RESEARCH WILL DETERMINE IF IMPROVING SOIL HEALTH AND BIODIVERSITY IN AGRICULTURAL LANDSCAPES CAN HELP FARMERS DEAL WITH A MORE UNPREDICTABLE FUTURE. EXPERIMENTAL RESULTS WILL PROVIDE BROADER IMPACTS THROUGH THE DISSEMINATION OF KNOWLEDGE ABOUT CARBON SEQUESTRATION TO STAKEHOLDERS AND POLICYMAKERS. THE USE OF PRAIRIE AND OTHER CONSERVATION AREAS TO ENHANCE ECOSYSTEM SERVICES WILL ALSO PROVIDE BROADER IMPACTS AND THE RESEARCH WILL REDUCE BARRIERS FOR UNDERREPRESENTED GROUPS IN STEM. RESILIENCE WILL BE DETERMINED ACROSS A GRADIENT OF LAND USE INTENSITIES, RANGING FROM CONVENTIONAL AGRICULTURE, TO PERENNIAL BIOENERGY CROPPING SYSTEMS, TO PRAIRIE AND OTHER NATURAL AREAS. LONG-TERM MEASUREMENTS SPANNING DIVERSE ORGANISMS, BIOPHYSICAL RESOURCES, BIOGEOCHEMICAL PROCESSES, AND CLIMATIC FACTORS WILL REVEAL LINKAGES AMONG ECOSYSTEM COMPONENTS THAT MAY BE KEY TO ENHANCING SYSTEM-LEVEL RESILIENCE. THREE CLASSES OF MECHANISMS ARE IDENTIFIED THAT UNDERLIE AGROECOSYSTEM RESILIENCE ? RESOURCES, DIVERSITY, AND ADAPTATION. THE OVERARCHING HYPOTHESIS IN THIS PROPOSAL IS THAT KNOWLEDGE OF THESE MECHANISMS ENABLES THE RESILIENCE OF KEY ECOSYSTEM PROCESSES TO BE PREDICTED AT FIELD, LANDSCAPE, AND REGIONAL SCALES. SPECIFIC HYPOTHESES FOCUS ON: SOIL RESOURCES EFFECTS ON WATER AVAILABILITY, CARBON STORAGE, AND GREENHOUSE GAS EMISSIONS; ON BIODIVERSITY EFFECTS OF MICROBIAL AND ARTHROPOD COMMUNITIES AT PLANT AND LANDSCAPE SCALES; ON EVOLUTIONARY ADAPTATION; AND ON FARMER ADAPTATION INFLUENCED BY BELIEFS AND VALUES. THESE HYPOTHESES WILL BE ADDRESSED WITH STRATEGICALLY DESIGNED EXPERIMENTS, INCLUDING A LARGE-SCALE RAINFALL MANIPULATION, THE INTRODUCTION OF PERENNIAL PRAIRIE STRIPS WITHIN AGRICULTURAL FIELDS, AND A FARMER SURVEY THAT WILL REACH THOUSANDS OF FARMERS ACROSS THE US MIDWEST. FINALLY, SCIENTISTS WILL INTRODUCE NEW TOOLS TO ADDRESS HOW RESILIENCE SCALES ACROSS LANDSCAPES THAT WILL ALLOW US TO EXTRAPOLATE SITE-SPECIFIC MEASUREMENTS TO THE REGION. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

FOOD-BODY-MIND INTERVENTION: PROMOTE WHOLE CHILD HEALTH - ABSTRACT MENTAL, EMOTIONAL, AND BEHAVIORAL (MEB) DISORDERS BEGIN IN EARLY CHILDHOOD, WITH ONE IN SIX US PRESCHOOLERS AGED 3-5 YEARS DIAGNOSED WITH A MEB DISORDER. CHILDREN FROM LOW INCOME AND ECONOMICALLY MARGINALIZED (LIEM) BACKGROUNDS HAVE A HIGHER RISK OF BEING DIAGNOSED WITH MEB DISORDERS THAN THOSE FROM HIGHER INCOME FAMILIES. TO ADDRESS THE MENTAL AND PHYSICAL HEALTH DISPARITIES BASED ON SOCIOECONOMIC STATUS, ETHNICITY/RACE, AND URBAN/RURAL RESIDENCY, THE PROPOSED STUDY WILL TARGET HEAD START RACIALLY/ETHNICALLY DIVERSE PRESCHOOLERS FROM LIEM BACKGROUNDS IN BOTH URBAN AND RURAL AREAS. GUIDED BY THE ACTOR-PARTNER INTERDEPENDENCE MODEL, THE ALLOSTATIC LOAD MODEL, AND THE TRANSACTIONAL THEORY OF STRESS AND COPING, THE PROPOSED 16-WEEK FOOD- BODY-MIND INTERVENTION INCLUDES: 1) A SCHOOL-BASED MINDFULNESS COMPONENT DELIVERED TO EQUIP PRESCHOOLERS WITH KNOWLEDGE AND SKILLS IN MINDFUL EATING AND MOVEMENT (E.G., YOGA, DEEP BREATHING EXERCISES); 2) A HOME- BASED MINDFULNESS COMPONENT TO INCREASE CAREGIVERS’ SKILLS IN PRACTICING MINDFUL EATING, MOVEMENT, AND PARENTING BEHAVIORS AT HOME TO FOSTER A MORE POSITIVE, MINDFUL, AND HEALTHY HOME ENVIRONMENT; AND 3) A SCHOOL LEARNING AND HOME PRACTICE CONNECTION COMPONENT TO IMPROVE CAREGIVER-PRESCHOOLER RELATIONSHIPS. THE PURPOSE OF THIS 5-YEAR CLUSTER RANDOMIZED CONTROLLED TRIAL IS TO EVALUATE THE EFFECTS OF THE 16-WEEK SCHOOL- AND HOME-BASED, MULTI-COMPONENT, FOOD-BODY-MIND INTERVENTION ON IMPROVING BOTH PRESCHOOLERS’ AND CAREGIVERS’ MEB AND PHYSICAL HEALTH. THE LONG-TERM GOAL IS TO ACHIEVE OPTIMAL WHOLE CHILD HEALTH IN EARLY CHILDHOOD TO FOSTER A HEALTHIER GENERATION IN THE US. FIFTY HEAD START DAYCARE CENTERS WILL BE RANDOMIZED INTO THE INTERVENTION (N=25: 8 URBAN [16 CLASSROOMS] AND 17 RURAL [17 CLASSROOMS] DAYCARE CENTERS) OR USUAL CARE CONTROL GROUP (N=25: 8 URBAN AND 17 RURAL DAYCARE CENTERS). FIVE CAREGIVER-PRESCHOOLER DYADS WILL BE RECRUITED FROM EACH DAYCARE CLASSROOM (TOTAL 330 DYADS: 160 URBAN DYADS AND 170 RURAL DYADS). ANALYSES WILL BE BASED ON THE INTENTION-TO-TREAT PRINCIPLE. THE THREE AIMS ARE TO: 1) DETERMINE EFFECTS OF THE INTERVENTION ON IMPROVING PRESCHOOLERS’ PRIMARY OUTCOMES INCLUDING MENTAL (CHRONIC STRESS), EMOTIONAL (SADNESS, FEAR, ANGER, POSITIVE AFFECT), AND BEHAVIORAL (PROBLEM BEHAVIORS, SOCIAL SKILLS) HEALTH AS WELL AS PHYSICAL HEALTH (BMI Z-SCORE, % BODY FAT; SECONDARY OUTCOMES) FROM BASELINE (0 MONTH) TO 4 MONTHS (IMMEDIATE POST-INTERVENTION) AND TO 12-MONTH FOLLOW-UP COMPARED TO CONTROL; 2) EXAMINE THE EFFECTS OF THE INTERVENTION ON IMPROVING CAREGIVERS’ PHYSICAL (BMI, % BODY FAT, BLOOD PRESSURE) AND MENTAL (STRESS, ANXIETY, DEPRESSION) HEALTH FROM 0 TO 4 MONTHS AND TO 12-MONTH FOLLOW-UP COMPARED TO CONTROL; AND 3) EXPLORE HOW THE INTERVENTION WILL MODIFY BOTH PRESCHOOLERS’ AND CAREGIVERS’ MEB AND PHYSICAL HEALTH VIA THE MEDIATING MECHANISMS OF MINDFULNESS, EMOTIONAL EATING, FRUIT/VEGETABLE INTAKE, PHYSICAL ACTIVITY, CAREGIVER-PRESCHOOLER RELATIONSHIP, AND CAREGIVER COPING FROM 0 TO 4 MONTHS AND TO 12-MONTH FOLLOW-UP. RESULTS FROM THIS STUDY WILL IMPROVE THE EVIDENCE BASE OF COMPLEMENTARY AND INTEGRATIVE HEALTH APPROACHES THAT CAN BE DELIVERED IN GEOGRAPHICALLY DIVERSE DAYCARE SETTINGS.

ROLE OF LATERAL HYPOTHALAMIC NEUROTENSIN NEURONS IN ENERGY BALANCE

THE PRECISION FRONTIER AT FRIB: MASSES, RADII, MOMENTS, AND FUNDAMENTAL INTERACTIONS

WINDOWS ON THE UNIVERSE: STUDY OF OPEN QUANTUM SYSTEMS IN ATOMIC NUCLEI

USAID EMPOWERED YOUTH

DIETARY LIPIDS AND SILICA-TRIGGERED AUTOIMMUNITY.

ROLE OF ENTERIC GLIA IN THE DEATH OF NEURONS DURING GUT INFLAMMATION

MICHIGAN STATE UNIVERSITY AGBIORESEARCH PROGRAMS FOR FFY-13

LOW TEMPERATURE TRANSCRIPTIONAL NETWORKS

WINDOWS ON THE UNIVERSE: OPEN QUANTUM SYSTEMS IN ATOMIC NUCLEI AT FRIB -THIS PROPOSAL SEEKS TO UNDERSTAND HOW PROTONS AND NEUTRONS INTERACT WHEN THEY ARE PLACED IN AN ENVIRONMENT WHERE THERE ARE FAR MORE NEUTRONS THAN PROTONS, ALSO KNOWN AS RARE ISOTOPES. THESE NEUTRON-RICH RARE ISOTOPES STRADDLE THE LIMIT OF EXISTENCE, WHICH DEFINES THE NEUTRON DRIP LINE, WHERE PROTONS AND NEUTRONS NO LONGER FORM A NUCLEUS BECAUSE THEY DO NOT ?STICK? TOGETHER (E.G., BECOME UNBOUND). THEY OFFER AN OPPORTUNITY TO EXPLORE THE UNIQUE SCIENCE OF SYSTEMS THAT INTERACT WITH THEMSELVES, ALSO REFERRED TO AS OPEN QUANTUM SYSTEMS. THIS RESEARCH WILL BE CONDUCTED AT WORLDWIDE SCIENTIFIC USER FACILITIES, AND PRIMARILY AT THE FACILITY FOR RARE ISOTOPE BEAMS IN MICHIGAN THAT IS ESTIMATED TO PRODUCE NEARLY 1,000 NEW ISOTOPES IN THIS REGION OF INTEREST. THE STRUCTURE AND PROPERTIES OF THESE ISOTOPES ARE HIGHLY RELEVANT FOR UNDERSTANDING ASTROPHYSICAL PROCESSES. IN ADDITION, THIS TOPIC HAS SPECIAL SIGNIFICANCE DUE TO ITS RELEVANCE TO QUANTUM COMPUTING, QUANTUM OPTICS, AND QUANTUM SENSING. A PART OF THE RESEARCH THAT WILL BE PERFORMED INVOLVES THE MONA COLLABORATION, WHICH CONSISTS OF A GROUP OF UNDERGRADUATE INSTITUTIONS THAT HAS HAD A MAJOR IMPACT ON RECRUITMENT OF STUDENTS TO ENTER NUCLEAR SCIENCE. THE RESEARCH WILL FURTHER DEVELOP THE LISE++ CODE THAT IS USED BY THOUSANDS OF SCIENTISTS AROUND THE WORLD FOR THE MODELING OF RARE ISOTOPE PRODUCTION. THE WORK WILL HAVE A SIGNIFICANT IMPACT ON DIVERSITY BY INVOLVEMENT OF MINORITY SERVING INSTITUTIONS IN THE PROPOSED RESEARCH AS WELL AS THE INVOLVEMENT OF PRE-COLLEGE STUDENTS TO TRAIN THE NEXT GENERATION OF THE SCIENCE, TECHNOLOGY, ENGINEERING, ART AND MATHEMATICS (STEAM) WORKFORCE. THIS PROPOSAL IS TO PERFORM EXPERIMENTAL STUDIES OF WEAKLY BOUND ATOMIC NUCLEI IN ORDER TO TEST NUCLEAR MODELS THAT ARE RELEVANT TO UNDERSTANDING OPEN QUANTUM SYSTEMS AND ASTROPHYSICAL PROCESSES IN THE UNIVERSE. PROPER MODELING AND UNDERSTANDING OF CONTINUUM EFFECTS ARE IMPORTANT IN THE ERA OF MULTI-MESSENGER ASTRONOMY WHERE NUCLEAR PROPERTIES, SUCH AS BINDING ENERGIES AND NUCLEAR RADII ARE RELEVANT FOR INTERPRETING OPTICAL, NEUTRINO, AND GRAVITATIONAL-WAVE OBSERVATIONS. IT WILL ADDRESS FUNDAMENTAL QUESTIONS, SUCH AS WHAT COMBINATION OF NEUTRONS AND PROTONS CAN FORM AN ATOMIC NUCLEUS AND PERHAPS DOUBLE OUR KNOWLEDGE OF THE NEUTRON DRIP LINE. PROPERTIES OF UNBOUND STATES WILL BE MEASURED USING THE POWERFUL TOOLS OF THE MONA COLLABORATION AND THE WIDE RANGE OF NEW NUCLEI ACCESSIBLE AT FRIB. NEW TECHNIQUES WILL BE DEVELOPED TO EXPLOIT QUASI-ELASTIC PROTON REMOVAL REACTIONS TO PROBE STATES NEAR THE PARTICLE EMISSION THRESHOLD AND THE STRUCTURE OF WEAKLY-BOUND NUCLEI, INCLUDING THE CHARACTERIZATION OF NEAR THRESHOLD RESONANCES IN LOOSELY BOUND SYSTEMS. FINALLY, DUE TO THE OPEN-QUANTUM NATURE OF THE STATES OF INTEREST, THE REACTION MECHANISM TO PRODUCE THESE STATES BECOMES AN IMPORTANT PART OF THE MEASUREMENT. THE ROLE OF THE REACTION MECHANISM IN THE CONTEXT OF OPEN QUANTUM SYSTEMS WILL BE EXPLORED WITH THE DEVELOPMENT OF DEDICATED EQUIPMENT (E.G., CHERENKOV AND RUTHERFORD SCATTERING BASED DETECTORS). THIS PROJECT ADVANCES THE OBJECTIVES OF WINDOWS ON THE UNIVERSE: THE ERA OF MULTI-MESSENGER ASTROPHYSICS, ONE OF THE 10 BIG IDEAS FOR FUTURE NSF INVESTMENTS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

LTER: KBS - MECHANISMS OF RESILIENCE IN AGRICULTURAL LANDSCAPES

REQUEST AMMENDMENT TO DECEMBER 31, 2007.

MULTI-PARAMETER MONITORING OF BREAST CANCER PROGRESSION AND THERAPEUTIC RESPONSE

BUILDING AND OPERATING CHEMICAL FACTORIES: COMPARATIVE STUDIES OF BIOCHEMICAL PATHWAYS FOR SPECIALIZED METABOLITES IN THE SOLANUM

SYSTEMS SCIENCE CENTER FOR MUSCULOSKELETAL CAM THERAPIES

ACCELERATOR IMPROVEMENT PROJECT: ISOTOPE HARVESTING AT FRIB

INVESTIGATIONS IN ELEMENTARY PARTICLE PHYSICS AND PARTICLE ASTROPHYSICS

RESEARCH-PGR: A GENOME-LEVEL APPROACH TO BALANCING THE VITAMIN CONTENT OF MAIZE GRAIN

SMITH LEVER 3B&C FUNDS

SMITH LEVER 3B&C FUNDS

COMPREHENSIVE APPROACHES TO ADDRESSING MENTAL HEALTH NEEDS AND ENHANCING SCHOOL SECURITY: A CLUSTER RANDOMIZED CONTROLLED TRIAL

THERMOELECTRIC CONVERSION OF WASTE HEAT TO ELECTRICITY IN AN IC ENGINE POWERED VEHICLE

MSU TRAINEESHIP PROGRAM TO ADDRESS CRITICAL WORKFORCE NEEDS IN ACCELERATOR SCIENCE & ENGINEERING

MALI FOOD SECURITY POLICY (FSP) RESEARCH PROGRAM

SPARTAN KIDS-CHILD CARE ACCESS MEANS PARENTS IN SCHOOL (CCAMPIS)

GENETIC SILENCING OF STRIATAL CAV1.3 CALCIUM CHANNELS AS A POTENT ANTIDYSKINETIC THERAPY FOR PD

FIRST-ROW TRANSITION METAL-BASED CHROMOPHORES FOR DYE-SENSITIZED SOLAR CELLS: FUNDAMENTAL ISSUES

TAS::57 3600::TAS '(MURI 17) MULTIPACTOR AND BREAKDOWN SUSCEPTIBILITY AND MITIGATION IN SPACE-BASED RF SYSTEMS'

PROJECTION-SPECIFIC GENE EXPRESSION IN RESILIENCE TO CHRONIC STRESS

CENTERS OF EXCELLENCE

DEVELOPMENT OF NEW CARBOHYDRATE SYNTHESIS METHODOLOGIES

MICHIGAN STATE UNIVERSITY AGBIORESEARCH PROGRAMS FOR FFY-15

MICHIGAN STATE UNIVERSITY AGBIORESEARCH HATCH PROGRAMS FOR FFY-16

NEUROTOXIC MECHANISM OF METHYLMERCURY POISONING

UNIVERSITY TRANSPORTATION CENTER

ADVANCE INSTITUTIONAL TRANSFORMATION AWARD: ADVANCING DIVERSITY THROUGH ALIGNMENT OF POLICIES AND PRACTICES (ADAPP)

MAMMARY CARCINOGENESIS: PUBERTAL AND ADULT EFFECTS OF HIGH FAT DIET+OXYBENZONE

WHAT IS ENDOMETRIOSIS? DEEP PHENOTYPING TO ADVANCE DIAGNOSIS AND TREATMENT

MEETING WOMEN WHERE THEY ARE: MULTILEVEL INTERVENTION ADDRESSING RACIAL DISPARITIES IN MATERNAL MORBIDITY AND MORTALITY

NUTRI-FRIJOL ASSOCIATE AWARD

A TWIN STUDY OF EXOGENOUS HORMONE EXPOSURE AND RISK FOR BINGE EATING

IMPROVING EDUCATION SYSTEMS THROUGH INTERDISCIPLINARY TRAINING AND PRACTICE: APPLYING SOCIAL SCIENCE TO EDUCATION POLICY AND IMPLEMENTATION RESEARCH

PD CHANGES

NEW:SISGR - CHARACTERIZATION AND MODELING OF DEFORMATION INDUCED DAMAGE IN TITANIUM ALLOYS; PI-CARL BOEHLERT

NAPAS ACTIVITY

CULTURE?SPECIFIC NEURODEVELOPMENTAL ASSESSMENT OF HIV-AFFECTED CHILDREN

A GLOBAL TROPICAL FOREST INFORMATION CENTER- TRFIC 2.

SOLID-STATE NMR OF VIRAL FUSION PEPTIDES AND PROTEINS

MICHIGAN STATE UNIVERSITY STUDENT SUPPORT SERVICES

** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** BLUEBERRIES ARE A NATIVE AMERICAN FRUIT AND QUALITY IS CRITICAL FOR DOMESTIC AND EXPORT MARKETS. BLUEBERRIES MUST WITHSTAND HARVESTING, STORAGE, PACKAGING, AND SHIPPING. IN THE U.S., REDUCED AVAILABILITY OF HAND LABOR AND RISING LABOR COSTS FOR HARVESTING FRESH FRUIT ARE CREATING A COMPETITIVE ADVANTAGE FOR FOREIGN PRODUCERS.U.S. GROWERS ARE CHALLENGED WITH ADOPTING NEW TECHNOLOGIES INCLUDING MECHANICAL HARVESTERS AND IMPROVED GRADING AND SORTING LINES TO REMAIN COMPETITIVE. HOWEVER, ADOPTION OF THESE NEW TECHNOLOGIES ALSO RESULTS IN INCREASED CROP LOSS DUE TO REDUCTIONS IN BERRY QUALITY. ALTERATIONS TO THE CURRENT PRODUCTION SYSTEMS ARE NECESSARY TO BETTER ADAPT TO THESE CHANGES. THIS PROJECT IS AIMED AT INCREASING COMPETITIVENESS AND SUSTAINABILITY OF THE U.S. BLUEBERRY INDUSTRY BY DEVELOPING METHODS TO IMPROVE FRUIT QUALITY AND REDUCE CROP LOSS.THE BLUE-DYNAMO TEAM WILL CONTINUE ITS ONGOING RESEARCH EFFORTS TO ADDRESS CHALLENGES TO FRUIT QUALITY THROUGH THIS PROJECT. RESEARCH OBJECTIVES SUCH AS MEASURINGPATHOGEN DIVERSITY, COLLECTING CROP PRODUCTION DATA TO CORRELATE WITH FRUIT ROT, AND STUDYING REGIONAL PRODUCTION EFFECTS ON MICROBIAL COMMUNITIES ARE A FEW MAIN FOCI. THIS WILL INITIATE A SIGNIFICANT CONNECTION WITH OUR GROWER STAKEHOLDERS THROUGHOUT THE PROJECT AND FACILITATE THE ENTERPRISE BUDGETS TO BE MODIFIED TO REFLECT CURRENT, REGIONAL GROWER PRACTICES. THE OVERALL OUTPUT FROM THIS PROPOSAL IS THE BLUE-DYNAMO WEBSITE WHICH INCLUDES MANAGEMENT PRACTICES, ECONOMICS, SAFETY TO POLLINATORS, AND EFFICACY.

CENTER FOR HIERARCHICAL AND ROBUST MODELING OF NON-EQUILIBRIUM TRANSPORT (CHARMNET)

PIRE: CRAFTING OPTIMAL LEARNING IN SCIENCE ENVIRONMENTS

INTERREGIONAL RESEARCH PROJECT NO. 4 MINOR CROP PEST MANAGEMENT FOR THE NORTH CENTRAL REGION

FOOD SECURITY III PROGRAM

ANDROGEN TARGETS IN A SIMPLE BEHAVIORAL SYSTEM.

THIS PROPOSAL WILL SUPPORT THE NORTH CENTRAL REGIONAL (NCR) IR-4 CENTER AT MICHIGAN STATE UNIVERSITY, INCLUDING A REGIONAL ANALYTICAL CHEMISTRY LABORATORY. PARTNERS AND COLLABORATORS CONDUCTING FIELD RESEARCH, QUALITY ASSURANCE OVERSIGHT, OR SERVING ON ADVISORY COMMITTEES, WILL COMPRISE UNIVERSITY FACULTY AT SAES UNITS IN ELEVEN OF THE TWELVE NCR STATES WITH THE EXCEPTION OF MISSOURI, THE USDA-ARS MINOR CROP UNIT, AND ONE PRIVATE CONTRACTOR. SINCE THE PLANT PROTECTION INDUSTRY HAS LITTLE ECONOMIC INCENTIVE TO DEVELOP REGISTRATIONS FOR SPECIALTY CROP CHEMICALS, IR-4 DEVELOPS THE DATA THAT PROVIDE LEGAL, EFFECTIVE, ECONOMIC, SAFE AND IPM-COMPATIBLE PEST CONTROL SOLUTIONS. WITHOUT THIS PROGRAM, MANY SPECIALTY CROPS COULD NO LONGER BE PRODUCED IN THE USA OR WOULD BE GREATLY COMPROMISED IN COST AND QUALITY, WITH SEVERE ECONOMIC IMPLICATIONS FOR AMERICAN AGRICULTURE, FOOD PROCESSORS, AND CONSUMERS. THE PROJECT'S OBJECTIVES FOR SPECIALTY CROPS ARE TO OBTAIN PESTICIDE CLEARANCES FOR FOODUSES, CONDUCT RESEARCH TO PROTECT ORNAMENTAL CROPS FROM KEY PESTS, AND FURTHER THE DEVELOPMENT AND ADOPTION OF BIOPESTICIDES. PEST MANAGEMENT NEEDS ARE IDENTIFIED REGIONALLY AND NATIONALLY AND PRIORITIZED BY RESEARCH AND EXTENSION PERSONNEL, FARMERS, GROWER ORGANIZATIONS AND OTHERS. FOR FOOD CROPS, FIELD TRIALS ARE CONDUCTED UNDER GOOD LABORATORY PRACTICES AND CROP SAMPLES ARE ANALYZED FOR THE MAGNITUDE OF RESIDUES. PERFORMANCE AND CROP SAFETY STUDIES ARE REQUIRED ON CERTAIN PEST/CROP COMBINATIONS BEFORE RESEARCH AND REGISTRATION CAN PROCEED. THE REPORTS OF THESE STUDIES, AFTER QUALITY ASSURANCE CHECKS, ARE FORWARDED TO IR-4 HQ AND USEPA. IN 2019 THE NCR, THROUGH REGIONAL COOPERATORS, WILL CONDUCT 39 FOOD CROP FIELD RESIDUE TRIALS AND 11 EFFICACY STUDIES. THE NCR LABORATORY WILL ANALYZE THE MAGNITUDE OF RESIDUES FOR 16 NEW PROJECTS FROM SUCH FIELD TRIALS. EFFICACY STUDIES ON DIFFICULT-TO-CONTROL PESTS ARE ALSO FUNDED. IN 2019, THE NCR WILL CONDUCT 43 TRIALS TO ASSESS THE SAFETY OF PESTICIDES ON ORNAMENTAL CROPS AND 40 EFFICACY STUDIES. ALSO IN 2019, THE NCR WILL CONDUCT 4 BIOPESTICIDE PROJECTS AS ASSIGNED TO COLLABORATORS IN THE NCR.

DYNAMICAL NANOSCALE CRYSTALLOGRAPHY WITH FEMTOSECOND RESOLUTION

THE NORTH CENTRAL IPM CENTER (NCIPMC) AND ITS BROAD-BASED NETWORK OF PARTNERS FACILITATE THE DEVELOPEMNT AND ADOPTION OF IPM SOLUTIONS THROUGH REGIONAL, MULTI-REGIONAL AND NATIONAL COOPERATION AND COLLABORATION. THESE INTERACTIVE INFORMATION NETWORKS FOSTER NOVEL PARTNERSHIPS AND PROVIDE EXPERTISE AND SUPPORT FOR OUR SIGNATURE PROGRAMS. THE NCIPMC WILL BE RESPONSIVE AND RELEVANT, WHILE PRODUCING QUALITY PRODUCTS THAT ACHIEVE DESIRED OUTCOMES. WE WILL CONTINUE TO EXPAND OUR CONNECTIONS WITH STAKEHOLDERS TO INCREASE IPM IMPLEMENTATION WHILE PROGRESSING TOWARDS THE GOALS OF THE IPM ROADMAP AND INCREASING FOOD SECURITY.

A TWIN STUDY OF ANDROGEN EFFECTS ON BINGE EATING RISK DURING PUBERTY IN MALES

NEURO-IMMUNE MECHANISMS IN EARLY LIFE STRESS-INDUCED GASTROINTESTINAL DISEASE

CORE RESEARCH AND DEVELOPMENT SUPPORT FOR ISOTOPE HARVESTING AT FRIB

IMPROVING DIABETIC PATIENTS? ADHERENCE TO TREATMENT AND PREVENTION OF CARDIOVASCULAR DISEASE

LARVAL MOSQUITO FEEDING AND MICROBIAL INTERACTIONS

THE KBS LTER PROJECT: LONG-TERM ECOLOGICAL RESEARCH IN ROW-CROP AGRICULTURE

IMPROVED METHOD FOR IDENTIFYING CAUSATIVE ANTIGEN IN HYPERSENSITIVITY PNEUMONITIS

THE NORTHERN FORESTS ARE IMPORTANT TO THE UNITED STATES AND CANADA BY HELPING TO MAINTAIN THE WATER QUALITY OF THE GREAT LAKES AND STORING CARBON AND PROVIDING HABITAT TO MILLIONS OF PLANTS AND ANIMALS INCLUDING NUMEROUS SPECIES IDENTIFIED OF GREATEST CONSERVATION NEED AND ACTING AS A MAJOR DRIVER FOR NORTHERN ECONOMIES THROUGH TIMBER AND RECREATION RELATED JOBS. ADDRESSING THE COMPLEXITY AND WIDESPREAD NATURE OF THREATS AND CHALLENGES TO THE RESILIENCE AND INTEGRITY OF NORTHERN FORESTS REQUIRES COLLECTIVE ACTION AND A QUANTITATIVE UNDERSTANDING OF FOREST CONDITIONS AND AN ADAPTIVE APPROACH FROM FOREST OWNERS. A THOROUGH INVENTORY OF EXISTING CONDITIONS IS NECESSARY FOR MAKING INFORMED DECISIONS AND FOR ASSESSING FOREST RESILIENCY. REFUGES DO NOT CURRENTLY HAVE A RELIABLE FOREST INVENTORY TO BASE LOCAL MANAGEMENT DECISIONS ON NOR A CONSISTENT SURVEY PROTOCOL FOR LANDSCAPE SCALE ACTIONS. MNFI WITH INVOLVEMENT FROM FWS WILL DELINEATE FOREST STANDS AND DEVELOP SAMPLING DESIGN PROTOCOLS AND DATABASE FOR MANAGEMENT LEVEL INVENTORY AND MORE IN DEPTH LONG TERM FOREST PLOT DATA AND ANALYZE DATA. MNFI WILL ALSO MANAGE THEIR STAFF AND CONTRACTORS TO COLLECT DATA IN SELECT REFUGES IN MICHIGAN AND MINNESOTA AND WISCONSIN TO INFORM PLANNING AND RESOURCE MANAGEMENT DECISIONS AT MULTIPLE SCALES WITHIN THE SERVICE. FWS AND MNFI WILL DELIVER SAMPLING PROTOCOLS AND DATASETS AND WRITTEN REFUGE AND REGIONAL REPORTS. THE BENEFICIARIES TO THIS EFFORT WILL BE REFUGE PLANNERS AND MANAGERS AND REGIONAL FWS CONSERVATION EFFORTS AND OTHERS MANAGING NORTHERN FOREST. SUBRECIPIENTS OF THIS AWARD INCLUDE LOCAL FOREST EXPERTS AND FIELD TECHNICIANS FROM BOTH MINNESOTA AND WISCONSIN.

MSUE PROGRAMS, FFY-11

NEW; SISGR - UNDERSTANDING AND CONTROLLING STRONG-FIELD LASER INTERACTIONS WITH POLYATOMIC MOLECULES; PI: MARCOS DANTUS

REDUCING PARTICULATE MATTER-ASSOCIATED CARDIOVASCULAR HEALTH EFFECTS FOR SENIORS

GIRLS ON THE MOVE INTERVENTION

BRIDGE THE THE PHD IN NEUROSCIENCE

MECHANISMS OF XENOBIOTIC-INDUCED BILIARY INFLAMMATION AND FIBROSIS

COMMUNITY ASSESSMENT AND EDUCATION TO PROMOTE BEHAVIORAL HEALTH PLANNING AND EVALUATION (CAPE 2)