Quest Inc

RESIDENTIAL (SHELTER AND/OR TRANSITIONAL FOSTER CARE) SERVICES FOR UNACCOMPANIED CHILDREN-LICENSED AND TEXAS-EXEMPT AND FLORIDA-DELICENSED ONLY - THE GWEN MIKEAL VILLAGE IS A UNACCOMPANIED MINOR SHELTER FOR FEMALE UC AGES 5 TO 17 WITH A FUNDED CAPACITY OF 50, LOCATED IN TUCSON, ARIZONA. THE PROGRAM OFFERS FULL ON SITE EDUCATION, CASE MANAGEMENT SERVICES, AND CLINICAL SERVICES. SIGNIFICANT ACCOMPLISHMENTS FROM NOVEMBER OF 2022 TO JULY OF 2023: THE PROGRAM HAS A SUCCESSFUL DISCHARGE RATE OF 101.68% DURING THAT TIME PERIOD. TOTAL YOUTH SERVED:438 TOTAL YOUTH DISCHARGED: 438 409 YOUTH WERE REUNIFIED WITH FAMILY IN THE COMMUNITY 1 RUNAWAY 4 YOUTH AGED-OUT AND WERE RELEASED ON THEIR OWN RECOGNIZANCE 9 AGE-REDETERMINATIONS 14 YOUTH WERE TRANSFERRED TO ANOTHER SHELTER 1 YOUTH WERE SUCCESSFULLY TRANSFERRED TO A LTFC PROGRAM

RESIDENTIAL (SHELTER AND/OR TRANSITIONAL FOSTER CARE) SERVICES FOR UNACCOMPANIED CHILDREN-LICENSED AND TEXAS-EXEMPT AND FLORIDA-DELICENSED ONLY - THE VQ SAM MAHAN CENTER IS A SHELTER CARE PROGRAM FOR MALE UC AGES 12 TO 17 WITH A FUNDED CAPACITY OF 48, LOCATED IN BENSON, ARIZONA. THE PROGRAM OFFERS FULL ON SITE EDUCATION, CASE CASE MANAGEMENT AND CLINICAL SERVICES. FOR THE CALENDAR YEAR OF 2022: THE PROGRAM HAS A SUCCESSFUL DISCHARGE RATE OF 100% (ALL DISCHARGES EXCEPT RUNAWAYS) TOTAL YOUTH SERVED: 420; 4 AGE REDETERMINATIONS; 1 SUCCESSFULLY TRANSFERRED TO URM PROGRAM; 411 REUNIFICATIONS; 4 TRANSFERS TO OTHER ORR PROGRAMS

BIPARTISAN INFRASTRUCTURE LAW (BIL): RIVER PARISH SEQUESTRATION - A CRITICAL CARBON STORAGE HUB FOR THE LOUISIANA CHEMICAL CORRIDOR THE PURPOSE OF THIS PROJECT IS TO DEVELOP A CARBON DIOXIDE (CO2) TRANSPORTATION AND STORAGE SOLUTION LOCATED IN THE LOUISIANA CHEMICAL CORRIDOR BETWEEN BATON ROUGE AND NEW ORLEANS. THE PROJECT WILL COMPLETE THE SITE CHARACTERIZATION AND PERMITTING WORK NECESSARY TO ACHIEVE LARGE-SCALE COMMERCIALIZATION FOR CO2 TRANSPORTATION AND STORAGE SERVICE FOR THE LOUISIANA CHEMICAL CORRIDOR IN 2027.

RESIDENTIAL (SHELTER AND/OR TRANSITIONAL FOSTER CARE) SERVICES FOR UNACCOMPANIED CHILDREN-LICENSED AND TEXAS-EXEMPT AND FLORIDA-DELICENSED ONLY

BIPARTISAN INFRASTRUCTURE LAW (BIL): A BIOMASS CARBON DIOXIDE CAPTURE AND REMOVAL PROJECT AT A PULP MILL IN ALABAMA THE OVERALL OBJECTIVES OF THIS PROJECT ARE TO ADVANCE DEVELOPMENT OF THE FOLLOWING MILESTONES: THE REGULATORY AUTHORITIES HAVE THE NECESSARY INFORMATION TO DETERMINE THAT THE INJECTION LOCATION IS SUITABLE FOR GEOLOGIC STORAGE OF CARBON DIOXIDE (CO2); THE PUBLIC HAS BEEN INFORMED AND THE COMMUNITY AND STAKEHOLDER SUPPORT HAS BEEN GENERATED FOR THE PROJECT; THE PROJECT RISK HAS BEEN EVALUATED SUFFICIENTLY TO ACHIEVE COMMERCIAL COMMITMENTS; ALL CRITICAL PERMIT APPLICATIONS HAVE BEEN SUBMITTED; ALL NECESSARY ENGINEERING WORK HAS BEEN COMPLETED TO ACHIEVE FINANCIAL CLOSE AND BEGIN EXECUTING THE PROJECT AS SOON AS RELEVANT PERMITS ARE RECEIVED FROM REGULATORY AUTHORITIES.. THE BENEFICIARIES OF THIS PROJECT INCLUDE THE REGULATORY AUTHORITIES AND STAKEHOLDERS OF THE PROJECT (INVESTORS AND CO2 OFFSET COUNTERPARTIES). THE PUBLIC WILL ALSO BENEFIT THROUGH OUTREACH AND ENGAGEMENT DESIGNED TO ENHANCE EDUCATION ABOUT CARBON CAPTURE AND SEQUESTRATION AND SOLICIT FEEDBACK REGARDING THE PROJECT.

RESIDENTIAL (LONG TERM FOSTER CARE) SERVICES FOR UNACCOMPANIED CHILDREN

RESIDENTIAL LONG TERM FOSTER CARE SERVICES FOR UNACCOMPANIED ALIEN CHILDREN

BIPARTISAN INFRASTRUCTURE LAW (BIL) - MAGNOLIA SEQUESTRATION PROJECT THIS PROJECT WILL PROVIDE A FEASIBILITY ASSESSMENT OF THE TECHNICAL AND NON-TECHNICAL ASPECTS OF AN INTEGRATED CARBON STORAGE PROJECT IN THE LAKE CHARLES AREA OF LOUISIANA. THE OVERALL OBJECTIVE OF THE PROJECT IS TO ADVANCE COMMERCIALITY OF CARBON CAPTURE AND STORAGE (CCS) IN THIS REGION BY CHARACTERIZING A POTENTIAL CARBON STORAGE SITE AND ESTABLISH DEVELOPMENT PLANS FOR THE STORAGE FIELD.

RESIDENTIAL (LONG TERM FOSTER CARE) SERVICES FOR UNACCOMPANIED CHILDREN

RESIDENTIAL (LONG TERM FOSTER CARE) SERVICES FOR UNACCOMPANIED CHILDREN

RESIDENTIAL SHELTER SERVICES FOR UNACCOMPANIED ALIEN CHILDREN

BIPARTISAN INFRASTRUCTURE LAW (BIL) - BLUEBONNET SEQUESTRATION PROJECT

DEVELOPMENT AND EVALUATION OF DUAL COMPARTMENT COMBINATION MICROBICIDES

RESIDENTIAL SHELTER SERVICES FOR UNACCOMPANIED ALIEN CHILDREN

VISIONQUEST'S RESIDENTIAL LONG TERM FOSTER CARE PROGRAM FOR UNACCOMPANIED CHILDREN

USAID NON-FORMAL EDUCATION PROGRAM

RESIDENTIAL (LONG TERM FOSTER CARE) SERVICES FOR UNACCOMPANIED CHILDREN

RECOVERY ACT

LONG ACTING ACCEPTABLE MICROBICIDES: NOVEL DELIVERY, ACTIVITY AND PHARMACODYNAMIC

HIGH GROWTH

VISIONQUEST RESIDENTIAL SHELTER CARE SERVICES FOR UNACCOMPANIED MINORS- CALIFORNIA

HIGH GROWTH

MALARIAL RETINOPATHY SCREENING SYSTEM FOR IMPROVED DIAGNOSIS OF CEREBRAL MALARIA

QUANTITATIVE BIOMARKERS OF T1D PERIPHERAL NEUROPATHY USING FUNCTIONAL IMAGING

VISIONQUEST STAFF SECURE RESIDENTIAL SERVICES FOR UNACCOMPANIED CHILDREN

SUCCESS FOR LIFE TEEN PREGNANCY PREVENTION PROGRAM (TIER 1B)

VISIONQUEST RESIDENTIAL SHELTER CARE SERVICES FOR UNACCOMPANIED MINORS IN TEXS

PURPOSE: TO PROVIDE GRANTS TO COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS (CDFIS) FOR THE FOLLOWING PURPOSES 1) TO EXPAND LENDING, GRANT MAKING AND INVESTMENT ACTIVITIES IN LOW OR MODERATE INCOME COMMUNITIES AND TO BORROWERS THAT HAVE HISTORICALLY EXPERIENCED SIGNIFICANT UNMET CAPITAL AND FINANCIAL SERVICES NEEDS AND WERE DISPROPORTIONATELY IMPACTED BY THE COVID 19 PANDEMIC; AND 2) TO ENABLE CDFIS TO BUILD ORGANIZATIONAL CAPACITY AND ACQUIRE TECHNOLOGY, STAFF, AND OTHER TOOLS NECESSARY TO ACCOMPLISH THE ACTIVITIES UNDER A CDFI ERP AWARD. PLANNED ACTIVITIES: ELIGIBLE ACTIVITIES INCLUDE FINANCIAL PRODUCTS, FINANCIAL SERVICES, DEVELOPMENT SERVICES, GRANTS, LOAN LOSS RESERVES AND CAPITAL RESERVES THAT MAY BE USED TO MITIGATE THE IMPACT OF THE COVID 19 PANDEMIC ON UNEMPLOYMENT, CHILDCARE, HEALTHCARE, MENTAL HEALTHCARE, AFFORDABLE HOUSING, AFFORDABLE HOUSING FINANCE, SMALL BUSINESS, SMALL FARMS, BROADBAND INTERNET, AND FOOD SUFFICIENCY. IN ADDITION, TO SUPPORT CDFIS IN BUILDING THEIR CAPACITY TO RESPOND TO THE ECONOMIC IMPACT OF COVID 19, CDFI ERP AWARDS MAY BE USED FOR COMPENSATION PERSONAL SERVICES; COMPENSATION FRINGE BENEFITS; PROFESSIONAL SERVICE COSTS; TRAVEL COSTS; TRAINING AND EDUCATION COSTS; EQUIPMENT; SUPPLIES. END GOALS: EXPANDED FINANCING FOR LOW TO MODERATE INCOME COMMUNITIES AND INDIVIDUALS THAT HAVE HISTORICALLY EXPERIENCED SIGNIFICANT UNMET CAPITAL AND FINANCIAL SERVICES NEEDS AND WERE DISPROPORTIONATELY IMPACTED BY THE COVID 19 PANDEMIC INCLUDING SPECIFIC DESIGNATED COVID IMPACTED CDFI ERP ELIGIBLE GEOGRAPHIES AS AREAS THAT MAY BENEFIT FROM CDFI ERP ASSISTANCE. BENEFICIARIES: CERTIFIED CDFIS WHICH MAY BE FOR PROFIT ORGANIZATION, PRIVATE NONPROFIT INSTITUTION/ORGANIZATION, AND OTHER PRIVATE INSTITUTION/ORGANIZATION, AS DEFINED IN 12 C.F.R. 1805, AND LOW AND MODERATE INCOME INDIVIDUALS AND FAMILIES. SUBRECIPIENTS: THERE ARE NO SUBRECIPIENTS FOR THIS PROGRAM. BROADBAND: SPECIFIC ACTIVITIES RELATING TO BROADBAND USAGE ARE NOT KNOWN AT THE TIME OF AWARD. REASON/PURPOSE OF MODIFICATION: NOT APPLICABLE.

QUESTEK INNOVATIONS LLC: NEW AWARD CONTROL NUMBER 2338-1507 ULTIMATE SBIR/STTR DE-FOA-0002338 PROJECT TITLE: “CONCURRENT DESIGN OF A MULTIMATERIAL NIOBIUM ALLOY SYSTEM FOR NEXT-GENERATION TURBINE APPLICATIONS'' THE PURPOSE OF THIS COOPERATIVE AGREEMENT IS TO DESIGN AND DEVELOP A COMPREHENSIVE SOLUTION FOR A NEXT-GENERATION TURBINE BLADE ALLOY AND COATING SYSTEM CAPABLE OF SUSTAINED OPERATION AT 1300°C.

AUTOMATIC EYE DISEASE SCREENING SYSTEM

COMPUTER BASED SCREENING FOR DIABETIC RETINOPATHY

QUEST RENEWABLES IS DEVELOPING A STANDALONE SOLAR RACKING SYSTEM THAT CAN BE PLACED IN AREAS WITH A HIGH-RISK OF NATURAL DISASTER TO PROVIDE STEADY ELECTRICITY DURING AND AFTER NATURAL DISASTERS.

PPHF2012: COMMUNITY TRANSFORMATION GRANTS - SMALL COMMUNITIES PROGRAMS

PHYSICS-BASED SIMULATOR TO TEACH HANDS-ON VASCULAR SURGICAL SKILLS

WASTE DISPOSAL GRANTS - REGULAR

COMPUTATIONAL MATERIALS DESIGN OF CASTABLE SX NI-BASED SUPERALLOYS FOR IGT BLADE COMPONENTS

SIMULATION-BASED WOUND CLOSURE TRAINING SYSTEM

MALARIAL RETINOPATHY SCREENING SYSTEM FOR IMPROVED DIAGNOSIS OF CEREBRAL MALARIA - SUMMARY CEREBRAL MALARIA (CM) IS A LIFE-THREATENING CLINICAL SYNDROME ASSOCIATED WITH MALARIAL INFECTION. IN 2018, MALARIA AFFECTED MORE THAN 213 MILLION PEOPLE IN AFRICA ALONE AND CLAIMED 381,000 LIVES, MORE THAN 65% OF WHOM WERE AFRICAN CHILDREN LESS THAN 5 YEARS OLD. AS A CONSEQUENCE OF THE HIGH INCIDENCE OF CM, IT IS OFTEN MISDIAGNOSED FOR OTHER PATHOLOGIES WITH SIMILAR SYMPTOMS, LEADING TO A HIGH FALSE POSITIVE RATE FOR CM, INCORRECT TREATMENT, AND RESULTING MORTALITY OR NEUROLOGICAL DISABILITY. THE SPECIFICITY OF THE CURRENT STANDARD OF CARE FOR CLINICAL DIAGNOSIS OF CM (PHYSICAL SYMPTOMS, COMA, AND MALARIA PARASITE TEST SUCH AS RAPID DIAGNOSTIC TESTING) IS REPORTED AROUND 61%. THEREFORE, THERE IS A SIGNIFICANT MARKET NEED FOR A HIGHLY SPECIFIC, LOW-COST, AND EASY-TO-USE TEST TO IMPROVE CM DIAGNOSIS AND SAVE LIVES. SINCE MALARIAL RETINOPATHY (MR) IS GREATER THAN 95% SPECIFIC TO THE PRESENCE OF CM, RETINAL SCREENING FOR MR REPRESENTS AN EFFECTIVE MEANS TO ASSIST IN AND IMPROVE THE SPECIFICITY OF CM DIAGNOSIS. SCREENING FOR MR IN ADDITION TO THE CURRENT STANDARD OF CARE IMPROVES THE SPECIFICITY OF CM DIAGNOSIS FROM 61% TO 100%. VISIONQUEST BIOMEDICAL HAS DEVELOPED ASPIRE, THE FIRST FULLY AUTOMATED MR DETECTION SOFTWARE INTEGRATED WITH A LOW-COST AND PORTABLE RETINAL CAMERA, A SYSTEM THAT CAN BE OPERATED BY MINIMALLY TRAINED PERSONNEL SUCH AS MEDICAL TECHNICIAN OR NURSE WITHOUT THE NEED OF AN OPHTHALMIC SPECIALIST. WE HAVE ASSEMBLED A MULTIDISCIPLINARY TEAM OF REGULATORY CONSULTANTS, COMMERCIALIZATION EXPERTS, BUSINESS DEVELOPMENT SPECIALISTS, AND CLINICIANS; TO CLINICALLY DEPLOY AND LAUNCH ASPIRE IN OUR TARGET MARKET IN AFRICA. THIS TEAM WILL VALIDATE AND PREPARE ASPIRE FOR REGULATORY CLEARANCE AS WELL AS FINALIZE THE MARKETING AND COMMERCIAL ROLLOUT STRATEGY. IN PHASE II-B, THE RESEARCH TEAM AT VISIONQUEST BIOMEDICAL DEPLOYED A FULLY-FUNCTIONAL CLINICAL VERSION OF ASPIRE AND TESTED IT IN NINE MALARIA CLINICS IN AFRICA, WHICH DEMONSTRATED EXCELLENT PERFORMANCE AND USABILITY FOR DETECTING MR, WITHOUT THE NEED OF AN OPHTHALMIC EXPERT. IN CRP, ASPIRE WILL BE VALIDATED FOR TECHNICAL AND CLINICAL PERFORMANCE AND WILL BE BROUGHT TO COMMERCIAL READINESS WITH REGULATORY CLEARANCE. WE WILL ACCOMPLISH THIS THROUGH FOUR SPECIFIC AIMS. IN THE FIRST AIM, THE SOFTWARE SYSTEM FOR MR DETECTION WILL BE VALIDATED TO BRING IT UNDER DESIGN CONTROLS. IN THE SECOND AIM, WE WILL DEPLOY ASPIRE AT 25 CLINICS IN AFRICA TO DEMONSTRATE SAFETY AND EFFICACY AS WELL AS TO PROMOTE MARKET TRACTION. THE THIRD AIM WILL FOCUS ON PREPARING ASPIRE FOR REGULATORY SUBMISSION. IN THE FOURTH AIM, WE WILL COMPLETE AFRICAN HEALTHCARE MARKET RESEARCH FOR A STARTUP MARKET OF 5 COUNTRIES (MALAWI, ZAMBIA, KENYA, UGANDA, RWANDA) AND FINALIZE MARKETING AND ROLLOUT STRATEGY. WITHIN ONE YEAR AFTER CRP, OUR GOAL WILL BE TO DEPLOY ASPIRE IN MORE THAN 200 MALARIA CLINICS ACROSS 5 COUNTRIES IN AFRICA.

ADAPTABLE AND SCALABLE ELECTROPORATION FOR CELLULAR THERAPY - PROJECT SUMMARY/ABSTRACT CELLULAR THERAPIES, IN WHICH LIVING CELLS ARE THE DRUG ADMINISTERED TO PATIENTS, HAVE THE POTENTIAL TO ADVANCE TREATMENT FOR A VARIETY OF INHERITED AND ACQUIRED DISEASES. IN PARTICULAR, CHIMERIC ANTIGEN RECEPTOR (CAR)-T THERAPIES HAVE SHOWN REMARKABLE EFFICACY IN CERTAIN HEMATOLOGICAL CANCERS. THE FIRST GENERATION OF APPROVED CAR-T THERAPIES RELY ON VIRAL VECTORS FOR CELLULAR REPROGRAMMING. VIRAL VECTORS HAVE ENABLED THE TRANSDUCTION OF TOUGH-TO-TRANSFECT PRIMARY T CELLS BUT HAVE SEVERAL DRAWBACKS RELATED TO THEIR RELATIVELY LENGTHY MANUFACTURING PROCESSES, IMMUNOGENICITY, AND POTENTIAL FOR INSERTIONAL MUTAGENESIS. FURTHERMORE, THE FIELD IS TRENDING TOWARDS MORE COMPLEX REPROGRAMMING METHODS, SUCH AS MULTIPLE GENE EDITS VIA CRISPR TECHNOLOGY, THAT ARE NOT COMPATIBLE WITH TYPICAL PACKAGING LIMITS ASSOCIATED WITH VIRAL APPROACHES. ELECTROPORATION IS A WELL-KNOWN METHOD FOR DELIVERY OF DNA, RNA, AND PROTEINS INTO CELLS, THAT IS RECOGNIZED AS THE LEADING REPLACEMENT FOR VIRAL DELIVERY. CYTEQUEST IS DEDICATED TO ADDRESS THE NEED FOR A FLEXIBLE ELECTROPORATION PLATFORM THAT CAN FACILITATE DISCOVERY AND EASILY SCALE CELL THERAPY MANUFACTURING FROM THE RESEARCH LEVEL (LOW-VOLUME) TO THE CLINICAL LEVEL (HIGH-VOLUME). CYTEQUEST HAS DEVELOPED A SCALABLE ELECTROPORATION PLATFORM TO OPTIMIZE TRANSFECTION PARAMETERS AND DELIVER CARGO EFFICIENTLY AND REPRODUCIBLY AT HIGH THROUGHPUT. THE PLATFORM INCORPORATES A SINGLE USE, CONTINUOUS-FLOW FLUIDIC SYSTEM DESIGNED TO INTEGRATE WITH AUTOMATED CELL PROCESSING APPROACHES. THE KEY OBJECTIVES OF THIS PROPOSAL ARE TO: (1) DESIGN, CONSTRUCT, AND TEST OPTIMIZATION INSTRUMENT PROTOTYPES CAPABLE OF MULTIPLEXED ELECTROPORATION (UP TO PARALLEL 8 CHANNELS) TO ENABLE RAPID OPTIMIZATION OF TRANSFECTION PARAMETERS AND USE THESE INSTRUMENTS WITH ACADEMIC AND CLINICAL COLLABORATORS TO ADVANCE THEIR CELL THERAPY PROGRAMS; AND (2) DESIGN, CONSTRUCT AND TEST MANUFACTURING INSTRUMENT PROTOTYPES CAPABLE OF RAPID DELIVERY OF CARGO TO MID AND HIGH VOLUMES OF CELLS TO ENABLE GMP-COMPATIBLE CELL MANUFACTURING WITHIN A CLOSED SYSTEM. CYTEQUEST’S GOAL IS TO EXPAND THE AVAILABILITY OF CELLULAR THERAPY TO TREAT A WIDER RANGE OF DISEASES AND EXTEND TREATMENT TO A MUCH BROADER PATIENT COMMUNITY.

DEVELOPMENT OF A SURGICAL SIMULATOR FOR ENDOVASCULAR ACCESS TRAINING

MECHANISM OF ACTION OF NOVEL DUAL ACTING PYRIMIDINEDIONES

PORTABLE HAND-HELD NON-MYDRIATIC RETINAL CAMERA

COMPUTER-BASED SCREENING FOR DIABETIC RETINOPATHY

RATIONAL DEVELOPMENT OF COMBINATION MICROBICIDE THERAPIES

POST IED INJURY RECONSTRUCTION

ENHANCED ALUMINUM CONDUCTOR FOR OVERHEAD ELECTRICAL TRANSMISSION APPLICATION

COMPUTATIONAL MATERIALS DESIGN OF FUNCTIONALLY GRADED STRUCTURES FOR ENHANCED COOLING OF PLASMA FACING COMPONENTS VIA ADDITIVE MANUFACTURING

OPEN COMPUTATIONAL INFRASTRUCTURE FOR SURGICAL SKILL DEVELOPMENT AND ASSESSMENT

SBIR-PHASE I NEW; COMPUTATIONAL DESIGN OF WELDABLE HIGH-CR FERRITIC STEEL; JAMES WRIGHT

ICME DEVELOPMENT OF A COLD SPRAY ENABLED CORROSION RESISTANT BIMETALLIC STRUCTURE FOR NUCLEAR REACTORS

COMPREHENSIVE ASSESSMENT OF RETINAL VASCULATURE (CARV)

MICROFLEX TECHNOLOGY FOR EARLY DETECTION OF LUNG DISEASE

AUTOMATED EYE DISEASE SCREENING SYSTEM

BUSINESS PARK IMPRVMENTS

AUGMENTED REALITY SYSTEM TO TEACH HEMOSTATIC AGENT USE IN HEMORRHAGE CONTROL

IMPROVED MODELS OF LONG TERM CREEP BEHAVIOR OF HIGH PERFORMANCE

MICROWAVE-FLUIDIZED CATALYTIC REACTOR FOR THE DIRECT CONVERSION OF METHANE TO HIGHER HYDROCARBONS

CALPHAD IN THE CLOUD

EXPLORATION OF HIGH ENTROPY ALLOYS FOR TURBINE APPLICATIONS

DEVELOPMENT OF A NOVEL NANOPARTICLE PYRIMIDINEDIONE VAGINAL POLYMERIC FILM AS AN

FULLY AUTOMATIC ROP SCREENING SYSTEM: NEOSCAN

CARDIAC SYNCHRONIZATION TECHNOLOGY: RESUSCITATION THERAPY - PULSELESS CARDIAC ARR

THERMAL IMAGING MODALITY FOR DETECTION OF LARGE AND SMALL FIBER DIABETIC PERIPHERAL NEUROPATHY - SUMMARY DIABETIC PERIPHERAL NEUROPATHY (DPN) AFFECTS UP TO HALF OF ALL DIABETIC PEOPLE, AND THE CENTERS FOR DISEASE CONTROL STATE THAT OVER 37 MILLION PEOPLE IN THE UNITED STATES NOW LIVE WITH DIABETES. ABOUT 20% OF PEOPLE ALREADY HAVE DPN WHEN THEY ARE DIAGNOSED WITH DIABETES, AND DPN CAUSES 82,000 LOWER EXTREMITY AMPUTATIONS ANNUALLY IN THE US. HEALTH-CARE PROVIDERS NEED AN ACCURATE MEANS TO DETECT EARLY STAGE DPN IN ORDER TO IMPROVE OUTCOMES. VISIONQUEST BIOMEDICAL HAS ASSEMBLED AN INTERDISCIPLINARY GROUP OF SCIENTISTS WITH EXPERIENCE IN AUTOMATED THERMAL IMAGE ANALYSIS, DIABETES COMORBIDITY DIAGNOSIS; AND TREATMENT OF DPN. OUR GOAL IS TO HAVE FDA CLEARANCE BY THE END OF THIS CRP GRANT FOR I-RXTHERM, OUR PATENTED DEVICE BASED ON THE PRINCIPLE THAT NEURONAL FACTORS AFFECTED BY DIABETES, ALTER THE THERMOREGULATION PROCESS IN DPN PATIENTS. THE CORE INNOVATION OF I-RXTHERM IS ITS ABILITY TO DETECT ANY TYPE OF DPN, SMALL OR LARGE FIBER, IN THE EARLY STAGES—A CAPABILITY THAT NO OTHER SINGLE DEVICE CURRENTLY HAS. DRIVEN BY OUR PHASE II SUCCESS, WE PLAN TO BEGIN THE COMMERCIALIZATION OF OUR DEVICE BY COMPLETING THE DOCUMENTATION AND TESTING PROCESS THAT WILL ALLOW US TO SUBMIT I-RXTHERM FOR FDA CLEARANCE AND. WE WILL ACCOMPLISH THESE GOALS THROUGH THE FOLLOWING SPECIFIC AIMS: AIM 1: PERFORM SOFTWARE VERIFICATION AND VALIDATION (V&V). WE WILL BRING I-RXTHERM UNDER DESIGN CONTROLS (COMPLIANCE WITH ISO 13485) AND PERFORM SOFTWARE V&V. AIM 2: IMPLEMENT I-RXTHERM AT PILOT CLINIC. WE WILL CONDUCT A CLINICAL RESEARCH STUDY (NOT A CLINICAL TRIAL) AND DEPLOY I-RXTHERM AT A PRIMARY CLINIC AT OUR UNIVERSITY COLLABORATOR’S FACILITIES TO DEMONSTRATE (1) EFFECTIVE CLINICAL DEPLOYMENT WORKFLOW AND (2) SAFETY AND EFFICACY. AIM 3: GAIN REGULATORY CLEARANCE. WE WILL WORK WITH RTG AND OUR REGULATORY PARTNERS, PHARMALEX AND COVELOCITY, TO COMPILE THE TECHNICAL FILE AND OTHER DOCUMENTATION FOR CLASS I APPROVAL IN MONTH 2 AND IN THE 12TH MONTH FOR A SUBMISSION TO THE FDA AS A 510(K) DEVICE. AIM 4: COMPLETE MARKET RESEARCH AND FINALIZE A ROLLOUT STRATEGY. WE WILL WORK WITH OUR MARKETING CONSULTANTS TO BUILD ON OUR PRELIMINARY MARKETING PLAN. THE FINAL MARKETING PLAN WILL BE IMPLEMENTED BY VISIONQUEST STAFF WITH THE ASSISTANCE OF THESE COLLABORATORS. BY THE END OF MONTH 3 OF THE CRP GRANT, WE WILL SUBMIT THE I-RXTHERM CLASS I FOR FDA CLEARANCE FOLLOWED BY A CLASS II CLEARANCE BY MONTH 12.

FY24 CONGRESSIONALLY FUNDED COMMUNITY PROJECTS-EQUIPMENT AND SUPPLIES FOR ARTSQUEST'S CULTURAL CENTER

RECIPIENT NAME PROJECT QUEST, INC.PROJECT TITLE THE INCLUSION, DIVERSITY, EQUITY, AND ACCESS, (IDEA) IN WORKFORCE INITIATIVEFUNDING REQUEST 1,000,000CONGRESSIONAL SPONSOR CONGRESSMAN JOAQUIN CASTROREQUESTED PERIOD OF PERFORMANCE 24 MONTHS, OCTOBER 1, 2023 SEPTEMBER 30, 2025PROJECT LOCATION SAN ANTONIO, TEXASPROJECT PURPOSE AND GOALS THE INCLUSION, DIVERSITY, EQUITY, AND ACCESS, (IDEA) IN WORKFORCE INITIATIVE SHARES THE STRATEGIC GOAL OF ENSURING UNEMPLOYED, UNDEREMPLOYED, OR UNDERSERVED RESIDENTS CAN ACCESS TRAINING AND EDUCATION THAT WILL LEAD TO HIGH DEMAND, WELL PAID CAREERSACTIVITIES TO BE PERFORMED QUEST ENABLES INDIVIDUALS TO RECEIVE EDUCATION AND TRAINING TO PREPARE THEM FOR JOB READINESS, PLACEMENT, AND RETENTION IN LIVING WAGE CAREERS WITHIN THREE MAJOR INDUSTRIES INCLUDING HEALTHCARE, INFORMATION TECHNOLOGY CYBERSECURITY, AND TRADES ADVANCED MANUFACTURING.QUEST IS A PARTICIPANT CENTERED MODEL THAT SERVES PARTICIPANTS BY HOLISTICALLY SUPPORTING EACH INDIVIDUALS UNIQUE NEEDS. QUEST HAS LEARNED THROUGH ITS 30 YEARS THAT IT IS NOT ONLY FINANCIAL SUPPORT THAT MATTERS BUT THE ABILITY TO BE AGILE AND RESPONSIVE SO ANY BARRIER TO SUCCESS IS REMOVED AS QUICKLY AS IT IS IDENTIFIED. PART OF THIS CALL TO ACTION CAN BE TO RESPOND WITH EMERGENCY FINANCIAL SUPPORT. QUEST OFFERS RENTAL UTILITY ASSISTANCE, MORTGAGE, CHILDCARE, TRANSPORTATION, AND OTHER KEY RESOURCES THAT ARE OFTEN NEEDED WHILE A PARTICIPANT IS COMMITTED TO A TRAINING PROGRAM. SERVING THEPARTICIPANT HOLISTICALLY ENSURES LONG TERM SUCCESS FOR THE PARTICIPANT IN THEIR EDUCATION AND THEIR CAREER.EXPECTED OUTCOMES A. EMPLOYMENT RATE 2ND QUARTER AFTER EXIT 75 B. EMPLOYMENT RATE 4TH QUARTER AFTER EXIT 75 C. MEDIAN EARNINGS 2ND QUARTER AFTER EXIT 18.50 HOURLY 30,784 ANNUALLYD. PERCENTAGE OF ENROLLED PARTICIPANTS EXPECTED TO GRADUATE THE PROGRAM OR RECEIVE SPECIFIED CREDENTIALING 80 E. PERCENTAGE OF ENROLLED PARTICIPANTS EXPECTED TO OBTAIN EMPLOYMENT 80 F. PERCENTAGE OF INDIVIDUALS EXPECTED TO RECEIVE A SPECIFIED SERVICE 100 INTENDED BENEFICIARIES THE INTENDED BENEFICIARIES ARE ADULTS (18 ) THROUGHOUT SAN ANTONIO (AND BEXAR COUNTY) WHO ARE UNEMPLOYED (NO JOB), UNDEREMPLOYED (LOW PAYING JOBS BELOW THEIR EDUCATION OR SKILL LEVEL) OR UNDER SKILLED (DO NOT POSSESS THE SKILLS REQUIRED TO COMPETE FOR LIVING WAGE JOBS).SUBRECIPIENT ACTIVITIES N A

MICROFLEX TOOLS TO IMPROVE SINUS DIAGNOSTICS AND SURGERY

DEVELOPMENT AND DISSEMINATION GRANT PROGRAM

COMMUNITY BASED ABSTINENCE EDUCATION

LOW-COST HIGH-RESOLUTION FUNDUS CAMERA

BURR HOLE CREATION SIMULATION-BASED TRAINING SYSTEM

A PUBLIC RESOURCE FOR THE FLEXIBLE USE OF AUGMENTED REALITY IN MEDICAL TRAINING SIMULATION

CAROL M. WHITE PHYSICAL EDUCATION PROGRAM

REAL-TIME, AUTOMATIC IMAGE QUALITY ASSESSMENT FOR DIGITAL FUNDUS CAMERA

**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** NON-TECHNICAL SUMMARY: MANY FACTORS ACTING TOGETHER, INCLUDING CONCERNS ABOUT WORKER SAFETY, FOOD SAFETY, PESTICIDE RESISTANCE AND NEW REGULATIONS GOVERNING PESTICIDES, HAVE HEIGHTENED GROWER AWARENESS TO REDUCE INSECTICIDE INPUTS AND INCREASE RELIANCE ON BIOPESTICIDES. FOREMOST AMONG THE FORCES LEADING TO CHANGE IS THE NEED TO REDUCE INPUT COSTS TO MAINTAIN ECONOMIC VIABILITY. MATING DISRUPTION IS AMONG THE MOST EFFECTIVE BIOPESTICIDES FOR MANAGING VARIOUS FRUIT CROP PESTS INCLUDING CODLING MOTH, OBLIQUE BANDED LEAFROLLER AND ORIENTAL FRUIT MOTH. ALTHOUGH THIS TACTIC HAS PROVEN TO BE A VIABLE ALTERNATIVE TO INSECTICIDES FOR SOME KEY PESTS, IT IS YET TO BE EMBRACED AS AN ECONOMICALLY VIABLE ALTERNATIVE TO INSECTICIDES IN MANY FRUIT PRODUCTION REGIONS. A MAJOR IMPEDIMENT TO WIDESPREAD ADOPTION OF DISRUPTION TECHNOLOGIES ARE THE NUMBER OF DEVICES NEEDED, TIMING, PHYSICAL APPLICATION OF THE PRODUCT, AND THE HIGH PRODUCT AND APPLICATION COSTS.OBJECTIVES: THE MAJOR AIM IN DEVELOPING THE TANGLER TRIFECTA TECHNOLOGY IS TO GREATLY IMPROVE THE MATING DISRUPTION APPLICATION PROCESS, AND SUBSTANTIALLY REDUCE ITS COST, ESPECIALLY THE APPLICATION COST, THEREBY INCREASING ADOPTION. THE TANGLER SYSTEM CONSISTS OF A BOLO LOADED WITH PHEROMONE AND A LAUNCHER THAT ENABLES THE GROWER TO RAPIDLY APPLY NUMEROUS MODULES TO THE UPPER TREE CANOPY. THE MODULE CONSISTS OF A CAP AND A BASE EACH MADE OF BIODEGRADABLE PLASTIC. AS A RESULT OF THE BOLA DESIGN, THE PROPELLED MODULES READILY BECOME TANGLED IN THE TREE BRANCHES. IT TOOK A SINGLE APPLICATOR 30 MINUTES TO TREAT A 1 HA ORCHARD WITH 1000. CURRENTLY, REGISTERED HAND-APPLIED DISRUPTION FORMULATIONS REQUIRE 3-4 HOURS TO TREAT A 1 HA ORCHARD AT THIS HIGH RATE. THE GREATLY IMPROVED EFFICIENCY PROVIDED BY TANGLER TRIFECTA WILL MEAN THAT GROWERS NO LONGER WILL NEED TO SKIMP ON THE NUMBER OF DISPENSERS APPLIED BECAUSE IT IS TIME CONSUMING AND LABOR INTENSIVE. MOREOVER, THEIR DEPENDENCE ON LABOR TO USE MATING DISRUPTION AND THE EXPENSE ASSOCIATED WITH THE APPLICATION WILL BE SUBSTANTIALLY REDUCED.

NON-TECHNICAL SUMMARY: MANY FACTORS ACTING TOGETHER, INCLUDING CONCERNS ABOUTWORKER SAFETY, FOOD SAFETY, PESTICIDE RESISTANCE AND NEW REGULATIONS GOVERNING PESTICIDES, HAVEHEIGHTENED GROWER AWARENESS TO REDUCE INSECTICIDE INPUTS AND INCREASE RELIANCE ON BIOPESTICIDES.FOREMOST AMONG THE FORCES LEADING TO CHANGE IS THE NEED TO REDUCE INPUT COSTS TO MAINTAINECONOMIC VIABILITY. MATING DISRUPTION IS AMONG THE MOST EFFECTIVE BIOPESTICIDES FOR MANAGINGVARIOUS FRUIT CROP PESTS INCLUDING ORIENTAL FRUIT MOTH. ALTHOUGH THIS TACTIC HAS PROVEN TO BE AVIABLE ALTERNATIVE TO INSECTICIDES FOR SOME KEY PESTS, IT IS YET TO BE EMBRACED AS AN ECONOMICALLYVIABLE ALTERNATIVE TO INSECTICIDES IN MANY FRUIT PRODUCTION REGIONS. A MAJOR IMPEDIMENT TOWIDESPREAD ADOPTION OF DISRUPTION TECHNOLOGIES ARE THE NUMBER OF DEVICES NEEDED, TIMING,PHYSICAL APPLICATION OF THE PRODUCT, AND THE HIGH PRODUCT AND APPLICATION COSTS.OBJECTIVES: THE MAJOR AIM IN DEVELOPING THE TANGLER TECHNOLOGY IS TO GREATLY IMPROVE THEMATING DISRUPTION APPLICATION PROCESS, AND SUBSTANTIALLY REDUCE ITS COST, ESPECIALLY THE APPLICATIONCOST, THEREBY INCREASING ADOPTION.THE TANGLER SYSTEM CONSISTS OF A MODULE LOADED WITH PHEROMONE AND A LAUNCHER THATENABLES THE GROWER TO RAPIDLY APPLY NUMEROUS MODULES TO THE UPPER TREE CANOPY. THE MODULECONSISTS OF A CAP AND A BASE EACH MADE OF BIODEGRADABLE PLASTIC. THE CAP IS ATTACHED TO THE BASEBY A COTTON STRING. DURING MANUFACTURING THE STRING AND RELEASE VESSEL ARE FUSED TO THE CAP. THESTRING IS INSERTED INTO THE BASE TO ALLOW THE CAP AND BASE TO BE ASSEMBLED. ONE HUNDRED TANGLERCAPSULES ARE COILED INTO 100 TANGLERS AND PLACED IN A BOX CLIP. THIS CLIP IS INSERTED INTO THELAUNCHER OPERATED BY COMPRESSED GAS. AS A RESULT OF THE BOLA DESIGN, THE PROPELLED MODULESREADILY BECOME TANGLED IN THE TREE BRANCHES. IT TOOK A SINGLE APPLICATOR 30 MINUTES TO TREAT A 1 HAORCHARD WITH 1000. CURRENTLY, REGISTERED HAND-APPLIED DISRUPTION FORMULATIONS REQUIRE 3-4 HOURSTO TREAT A 1 HA ORCHARD AT THIS HIGH RATE.THE GREATLY IMPROVED EFFICIENCY PROVIDED BY TANGLEROFM WILL MEAN THAT GROWERS NO LONGER WILL NEED TO SKIMP ON THE NUMBER OF DISPENSERS APPLIEDBECAUSE IT IS TIME CONSUMING AND LABOR INTENSIVE. MOREOVER, THEIR DEPENDENCE ON LABOR TO USEMATING DISRUPTION AND THE EXPENSE ASSOCIATED WITH THE APPLICATION WILL BE SUBSTANTIALLY REDUCED.APPROACH: FIRST, THIS RESEARCH PROJECT WILL DETERMINE THE EFFICACY OF THE TANGLER OFM FORSEASON LONG CONTROL AND THE LONG-TERM REDUCTION OF POPULATIONS. SECONDLY, COMPARE TANGLEROFM TO THE COMMERCIALLY AVAILABLE COMPETITOR, ISOMATE OFM (PACIFIC BIOCONTROL). THIRDLY,CLARIFY THE OPTIMAL RATE OF TANGLER OFM REQUIRED TO ACHIEVE MATING DISRUPTION, LONG TERMPOPULATION REDUCTION AND PREVENTION OF CROP DAMAGE. LASTLY, OPTIMIZE TANGLER OFM'SMEMBRANE TO ACHIEVE THE RELEASE OF ALL ACTIVE INGREDIENTS FOR THE DURATION OF THE OFM FLIGHT WITHEMPHASIS ON PROVIDING SUPERIOR MATING DISRUPTION.COMMERCIALIZATION: THE GOAL OF THIS RESEARCH WILL BE TO DEVELOP A HIGHLY EFFICIENT ANDEFFECTIVE MATING DISRUPTION PRODUCT FOR OFM THAT WILL PREVENT DAMAGE CAUSED BY THIS PEST ANDINCREASE GROWER ADOPTION OF THIS TECHNOLOGY IN ORGANIC AND COMMERCIAL FRUIT CROPS. FURTHERDEVELOPMENT OF THIS PRODUCT WILL LEAD TO BIODEGRADABLE DUAL OR TRIPLE DISPENSER WHICH WILLINCLUDE CODLING MOTH AND/OR OBLIQUE BANDED LEAFROLLER. ?

TANGLER LR TECHNOLOGY, ADVANCE MATING DISRUPTION THAT PROVIDES FOR RAPID AND COST EFFECTIVE APPLICATION

PURPOSE: THE CONTINUUM OF CARE (COC) PROGRAM IS DESIGNED TO PROMOTE COMMUNITY-WIDE COMMITMENT TO THE GOAL OF ENDING HOMELESSNESS; PROVIDE FUNDING FOR EFFORTS BY NONPROFIT PROVIDERS, STATES, AND LOCAL GOVERNMENTS TO QUICKLY HOUSE HOMELESS INDIVIDUALS AND FAMILIES WHILE MINIMIZING THE TRAUMA AND DISLOCATION CAUSED TO HOMELESS INDIVIDUALS, FAMILIES, AND COMMUNITIES BY HOMELESSNESS; PROMOTE ACCESS TO AND EFFECTIVE UTILIZATION OF MAINSTREAM PROGRAMS BY HOMELESS INDIVIDUALS AND FAMILIES; AND OPTIMIZE SELF-SUFFICIENCY AMONG INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS. THE MOST RECENT COC AWARD ANNOUNCEMENT LISTING AWARDS BY STATE AND COC IS ACCESSIBLE AT HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/COC/AWARDS. SELECT THE LINK UNDER THE FUNDING AND AWARD INFORMATION SECTION FOR THE APPROPRIATE FISCAL YEAR.; ACTIVITIES TO BE PERFORMED: CONTINUUM OF CARE PROGRAM FUNDS MAY BE USED TO PAY FOR THE ELIGIBLE COSTS USED TO ESTABLISH AND OPERATE PROJECTS UNDER FIVE PROGRAM COMPONENTS: (1) PERMANENT HOUSING, WHICH INCLUDES PERMANENT SUPPORTIVE HOUSING FOR PERSONS WITH DISABILITIES, AND RAPID REHOUSING; (2) TRANSITIONAL HOUSING; (3) SUPPORTIVE SERVICES ONLY; (4) HOMELESS MANAGEMENT INFORMATION SYSTEMS (HMIS), AND (5) IN SOME CASES, HOMELESSNESS PREVENTION. THIRTEEN TYPES OF ASSISTANCE MAY BE PROVIDED THROUGH THE CONTINUUM OF CARE (COC) PROGRAM: (1) COC PLANNING ACTIVITIES/COSTS FOR DESIGNING AND CARRYING OUT A COLLABORATIVE PROCESS FOR THE DEVELOPMENT OF AN APPLICATION TO HUD; (2) UNITED FUNDING AGENCY (UFA) COSTS FOR FISCAL CONTROL AND ACCOUNTING NECESSARY TO ASSURE THE PROPER DISBURSAL OF, AND ACCOUNTING FOR, FEDERAL FUNDS AWARDED TO SUBRECIPIENTS UNDER THE CONTINUUM OF CARE PROGRAM, (3) ACQUISITION OF REAL PROPERTY (INCLUDING STRUCTURES) FOR USE IN THE PROVISION OF HOUSING OR SUPPORTIVE SERVICES; (4) REHABILITATION OF STRUCTURES TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (5) NEW CONSTRUCTION, INCLUDING THE BUILDING OF A NEW STRUCTURE OR BUILDING AN ADDITION TO AN EXISTING STRUCTURE FOR USE AS SUPPORTIVE HOUSING; (6) LEASING OF A STRUCTURE OR STRUCTURES, OR PORTIONS THEREOF, TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (7) RENTAL ASSISTANCE, WHICH MAY BE SHORT-TERM, MEDIUM-TERM, OR LONG-TERM, AS WELL AS TENANT-BASED, PROJECT-BASED, OR SPONSOR-BASED, FOR TRANSITIONAL OR PERMANENT HOUSING; (8) SUPPORTIVE SERVICES TO ASSIST PROGRAM PARTICIPANTS OBTAIN AND MAINTAIN HOUSING; (9) OPERATING COSTS OF SUPPORTIVE HOUSING; (10) COSTS OF IMPLEMENTING AND OPERATING HMIS; (11) PROJECT ADMINISTRATIVE COSTS; (12) RELOCATION COSTS; AND (13) INDIRECT COSTS IN ACCORDANCE WITH 2 CFR PARTS 200, AS APPLICABLE. IN ADDITION TO USING GRANT FUNDS FOR THE ELIGIBLE COSTS DESCRIBED ABOVE, RECIPIENTS AND SUBRECIPIENTS IN CONTINUUMS OF CARE DESIGNATED AS HIGH PERFORMING COMMUNITIES MAY ALSO USE GRANT FUNDS TO PROVIDE HOUSING RELOCATION AND STABILIZATION SERVICES AND SHORT- AND/OR MEDIUM-TERM RENTAL ASSISTANCE TO INDIVIDUALS AND FAMILIES AT RISK OF HOMELESSNESS AS SET FORTH IN 24 CFR 576.103 AND 24 CFR 576.104, IF NECESSARY TO PREVENT THE INDIVIDUAL OR FAMILY FROM BECOMING HOMELESS. LIMITATION ON USE OF FUNDS: NO ASSISTANCE PROVIDED UNDER PROGRAM (OR ANY STATE OR LOCAL GOVERNMENT FUNDS USED TO SUPPLEMENT THIS ASSISTANCE) MAY BE USED TO REPLACE STATE OR LOCAL FUNDS PREVIOUSLY USED, OR DESIGNATED FOR USE, TO ASSIST HOMELESS PERSONS OR PERSONS AT-RISK OF HOMELESSNESS.; EXPECTED OUTCOMES: DECREASE IN THE NUMBER INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS, MORE SPECIFICALLY USING PERFORMANCE INDICATORS SUCH AS THE LENGTH OF TIME HOMELESS, RETURNS TO HOMELESSNESS OVER TIME, AND EXITS TO PERMANENT HOUSING. COC PERFORMANCE PROFILE REPORTS CAN BE FOUND AT HTTPS://WWW.HUDEXCHANGE.INFO/PROGRAMS/COC/COC-PERFORMANCE-PROFILE-REPORTS/.; INTENDED BENEFICIARIES: INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

RECENT OBSERVATIONS FROM THE CLUSTER MISSION HAVE SHOWN THAT DURING GEOMAGNETICALLY DISTURBED TIMES THE 0+ NUMBER DENSITY IN THE PLASMA SHEET CLOSE

IMPROVE EXISTING AIRPORT

RCN-UBE: QUANTITATIVE BIOLOGY AT COMMUNITY COLLEGES

NEW CA AWARD

HOMELESS ASSISTANCE

HIGHER EDUCATION EMERGENCY RELIEF FUND IHES/INSTITUTIONAL

HIGHER EDUCATION EMERGENCY RELIEF FUND - IHES FIRST 1/2 OF GRANT AWARD FOR DIRECT PAYMENT TO APPROXIMATELY 400 COLLEGE STUDENTS IMPACTED BY COVID-19 VIRUS

MALARIAL RETINOPATHY SCREENING SYSTEM FOR IMPROVED DIAGNOSIS OF CEREBRAL MALARIA

RCN-UBE: BUILDING OPEN EDUCATION ECOSYSTEMS TO FACILITATE THE ADOPTION AND ADAPTATION OF COMPUTATIONAL AND DATA-CENTRIC TOOLS ACROSS UNDERGRADUATE BIOLOGY EDUCATION (OEE-UBE) -BUILDING AND APPLYING MODERN BIOLOGICAL KNOWLEDGE DEPENDS ON USING ADVANCED COMPUTER TOOLS AND DATABASES TO GATHER INFORMATION, ANALYZE DATA, AND TEST IDEAS. UNFORTUNATELY, MANY COLLEGE STUDENTS DON?T GET ENOUGH EXPERIENCE WITH THESE METHODS TO PURSUE TECHNICAL CAREERS. TO ADDRESS THIS EXPERIENCE GAP, THE PROJECT PLANS TO CREATE A NETWORK THAT BRINGS TOGETHER EXISTING SCIENCE AND EDUCATION RESOURCES, MAKING THEM EASIER TO USE IN DIFFERENT TYPES OF INSTITUTIONS AND WITH DIVERSE STUDENT AUDIENCES. THIS NETWORK WILL BE ORGANIZED AROUND FOUR KEY AREAS: HIGH-PERFORMANCE COMPUTING, USING SCIENTIFIC DATA, MODELING AND SIMULATION, AND INTERACTIVE DATA TOOLS. BY MAKING THESE RESOURCES MORE ACCESSIBLE AND USER-FRIENDLY, THE PROJECT AIMS TO HELP FACULTY AND STUDENTS DEVELOP THEIR COMPUTATIONAL SKILLS AND BREAK DOWN BARRIERS TO PARTICIPATION IN THE SCIENTIFIC WORKFORCE, ESPECIALLY FOR STUDENTS FROM TRADITIONALLY UNDERREPRESENTED GROUPS. THIS RESEARCH COORDINATION NETWORK WILL OPERATE AT THE INTERFACE OF OPEN SCIENCE AND OPEN EDUCATION TO INTEGRATE EXISTING SCIENTIFIC AND EDUCATIONAL RESOURCES. ADOPTING FAIR PRINCIPLES (FINDABILITY, ACCESSIBILITY, INTEROPERABILITY, AND REUSABILITY) THAT BRIDGE SCIENTIFIC AND TEACHING RESOURCES WILL REQUIRE THE DEVELOPMENT AND IMPLEMENTATION OF A SHARED METADATA SCHEMA THAT AUTOMATES ROBUST CONNECTIONS BETWEEN OPEN EDUCATION RESOURCES (OER), COMPUTATIONAL TOOLS, AND SCIENTIFIC DATA REPOSITORIES. EACH OF THE FOUR FOCUS AREAS WILL BE SUPPORTED BY AN ONLINE OPEN EDUCATION ECOSYSTEM (OEE) WHERE INTERDISCIPLINARY PROFESSIONAL COMMUNITIES OF PRACTICE WILL WORK TO COORDINATE TEACHING AND SCIENTIFIC MATERIALS, SUPPORT FACULTY PROFESSIONAL LEARNING, AND FOSTER PEDAGOGIES THAT PROMOTE STUDENT ENGAGEMENT WITH CONTEMPORARY SCIENTIFIC PRINCIPLES AND PRACTICES. THROUGH THE WORK OF THE FOUR OEES THE NETWORK WILL DESIGN AN INFORMATION ARCHITECTURE TO SUPPORT STEM EDUCATION AND RESEARCH INTEROPERABILITY, SCALABLE CLASSROOM ACCESS TO COMPUTATIONAL RESOURCES, AND EMBEDDED CYBERTRAINING, PROMOTING EDUCATIONAL IMPACTS THAT EMPOWER MARGINALIZED LEARNER COMMUNITIES. THIS PROJECT IS BEING JOINTLY FUNDED BY THE DIRECTORATE FOR BIOLOGICAL SCIENCES, DIVISION OF BIOLOGICAL INFRASTRUCTURE, AND THE DIRECTORATE FOR STEM EDUCATION, DIVISION OF UNDERGRADUATE EDUCATION AS PART OF THEIR EFFORTS TO ADDRESS THE CHALLENGES POSED IN VISION AND CHANGE IN UNDERGRADUATE BIOLOGY EDUCATION: A CALL TO ACTION (HTTP://VISIONANDCHANGE/FINALREPORT/). THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

AWARD NUMBER DE-FE0031793 TO H QUEST VANGUARD INCORPORATED FOR PROJECT TITLED EFFICIENT ULTRA-RAPID MICROWAVE PLASMA PROCESS FOR GENERATION OF HIGH VALUE INDUSTRIAL CARBONS AND THREE-DIMENSIONAL PRINTABLE COMPOSITES FROM DOMESTIC COAL

CONTINUUM OF CARE PROGRAM

PURPOSE: THE CONTINUUM OF CARE (COC) PROGRAM IS DESIGNED TO PROMOTE COMMUNITY-WIDE COMMITMENT TO THE GOAL OF ENDING HOMELESSNESS; PROVIDE FUNDING FOR EFFORTS BY NONPROFIT PROVIDERS, STATES, AND LOCAL GOVERNMENTS TO QUICKLY HOUSE HOMELESS INDIVIDUALS AND FAMILIES WHILE MINIMIZING THE TRAUMA AND DISLOCATION CAUSED TO HOMELESS INDIVIDUALS, FAMILIES, AND COMMUNITIES BY HOMELESSNESS; PROMOTE ACCESS TO AND EFFECTIVE UTILIZATION OF MAINSTREAM PROGRAMS BY HOMELESS INDIVIDUALS AND FAMILIES; AND OPTIMIZE SELF-SUFFICIENCY AMONG INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS. THE MOST RECENT COC AWARD ANNOUNCEMENT LISTING AWARDS BY STATE AND COC IS ACCESSIBLE AT HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/COC/AWARDS. SELECT THE LINK UNDER THE FUNDING AND AWARD INFORMATION SECTION FOR THE APPROPRIATE FISCAL YEAR.; ACTIVITIES TO BE PERFORMED: CONTINUUM OF CARE PROGRAM FUNDS MAY BE USED TO PAY FOR THE ELIGIBLE COSTS USED TO ESTABLISH AND OPERATE PROJECTS UNDER FIVE PROGRAM COMPONENTS: (1) PERMANENT HOUSING, WHICH INCLUDES PERMANENT SUPPORTIVE HOUSING FOR PERSONS WITH DISABILITIES, AND RAPID REHOUSING; (2) TRANSITIONAL HOUSING; (3) SUPPORTIVE SERVICES ONLY; (4) HOMELESS MANAGEMENT INFORMATION SYSTEMS (HMIS), AND (5) IN SOME CASES, HOMELESSNESS PREVENTION. THIRTEEN TYPES OF ASSISTANCE MAY BE PROVIDED THROUGH THE CONTINUUM OF CARE (COC) PROGRAM: (1) COC PLANNING ACTIVITIES/COSTS FOR DESIGNING AND CARRYING OUT A COLLABORATIVE PROCESS FOR THE DEVELOPMENT OF AN APPLICATION TO HUD; (2) UNITED FUNDING AGENCY (UFA) COSTS FOR FISCAL CONTROL AND ACCOUNTING NECESSARY TO ASSURE THE PROPER DISBURSAL OF, AND ACCOUNTING FOR, FEDERAL FUNDS AWARDED TO SUBRECIPIENTS UNDER THE CONTINUUM OF CARE PROGRAM, (3) ACQUISITION OF REAL PROPERTY (INCLUDING STRUCTURES) FOR USE IN THE PROVISION OF HOUSING OR SUPPORTIVE SERVICES; (4) REHABILITATION OF STRUCTURES TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (5) NEW CONSTRUCTION, INCLUDING THE BUILDING OF A NEW STRUCTURE OR BUILDING AN ADDITION TO AN EXISTING STRUCTURE FOR USE AS SUPPORTIVE HOUSING; (6) LEASING OF A STRUCTURE OR STRUCTURES, OR PORTIONS THEREOF, TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (7) RENTAL ASSISTANCE, WHICH MAY BE SHORT-TERM, MEDIUM-TERM, OR LONG-TERM, AS WELL AS TENANT-BASED, PROJECT-BASED, OR SPONSOR-BASED, FOR TRANSITIONAL OR PERMANENT HOUSING; (8) SUPPORTIVE SERVICES TO ASSIST PROGRAM PARTICIPANTS OBTAIN AND MAINTAIN HOUSING; (9) OPERATING COSTS OF SUPPORTIVE HOUSING; (10) COSTS OF IMPLEMENTING AND OPERATING HMIS; (11) PROJECT ADMINISTRATIVE COSTS; (12) RELOCATION COSTS; AND (13) INDIRECT COSTS IN ACCORDANCE WITH 2 CFR PARTS 200, AS APPLICABLE. IN ADDITION TO USING GRANT FUNDS FOR THE ELIGIBLE COSTS DESCRIBED ABOVE, RECIPIENTS AND SUBRECIPIENTS IN CONTINUUMS OF CARE DESIGNATED AS HIGH PERFORMING COMMUNITIES MAY ALSO USE GRANT FUNDS TO PROVIDE HOUSING RELOCATION AND STABILIZATION SERVICES AND SHORT- AND/OR MEDIUM-TERM RENTAL ASSISTANCE TO INDIVIDUALS AND FAMILIES AT RISK OF HOMELESSNESS AS SET FORTH IN 24 CFR 576.103 AND 24 CFR 576.104, IF NECESSARY TO PREVENT THE INDIVIDUAL OR FAMILY FROM BECOMING HOMELESS. LIMITATION ON USE OF FUNDS: NO ASSISTANCE PROVIDED UNDER PROGRAM (OR ANY STATE OR LOCAL GOVERNMENT FUNDS USED TO SUPPLEMENT THIS ASSISTANCE) MAY BE USED TO REPLACE STATE OR LOCAL FUNDS PREVIOUSLY USED, OR DESIGNATED FOR USE, TO ASSIST HOMELESS PERSONS OR PERSONS AT-RISK OF HOMELESSNESS.; EXPECTED OUTCOMES: DECREASE IN THE NUMBER INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS, MORE SPECIFICALLY USING PERFORMANCE INDICATORS SUCH AS THE LENGTH OF TIME HOMELESS, RETURNS TO HOMELESSNESS OVER TIME, AND EXITS TO PERMANENT HOUSING. COC PERFORMANCE PROFILE REPORTS CAN BE FOUND AT HTTPS://WWW.HUDEXCHANGE.INFO/PROGRAMS/COC/COC-PERFORMANCE-PROFILE-REPORTS/.; INTENDED BENEFICIARIES: INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

DEVELOPMENT OF EMAT SENSORS FOR CORROSION MAPPING OF UNPIGGABLE NATURAL GAS PIPELINES USING ILI TOOLS

NEW YORK SAFE START PROJECT ABSTRACT QUESTAR III BOARD OF COOPERATIVE EDUCATIONAL SERVICES (BOCES) RESPECTFULLY REQUESTS FUNDING FOR THE NEW YORK SAFE START PROJECT. THROUGH THIS COMPREHENSIVE PROJECT, QUESTAR III IS PARTNERING WITH WSWHE BOCES AND 10 ADDITIONAL SCHOOL DISTRICTS TO LAUNCH EVIDENCE-BASED TECHNOLOGY PACKAGES THAT WILL DRAMATICALLY IMPROVE SAFETY AT 28 DIFFERENT SCHOOLS. NEW YORK SAFE START WILL BRING ANONYMOUS REPORTING, SOCIAL-EMOTIONAL LEARNING, AND PANIC NOTIFICATION TO ALL PARTNERING SCHOOLS.

CONTINUUM OF CARE PROGRAM

CONTINUUM OF CARE PROGRAM

INTEGRATED COMPUTATIONAL MATERIALS ENGINEERING-BASED EVALUATION AND OPTIMIZATION OF ADDITIVELY MANUFACTURED BLAST RESISTANT NAVAL STEELS

CONTINUUM OF CARE PROGRAM

DEVELOPMENT OF ANTIMICROBIAL PEPTIDES AS TOPICAL MICROBICIDES

CONTINUUM OF CARE PROGRAM

DEVELOPMENT OF A NOVEL SEMEN-ACTIVATED PRODRUG AS AN ANTI-HIV MICROBICIDE

PURPOSE: THE CONTINUUM OF CARE (COC) PROGRAM IS DESIGNED TO PROMOTE COMMUNITY-WIDE COMMITMENT TO THE GOAL OF ENDING HOMELESSNESS; PROVIDE FUNDING FOR EFFORTS BY NONPROFIT PROVIDERS, STATES, AND LOCAL GOVERNMENTS TO QUICKLY HOUSE HOMELESS INDIVIDUALS AND FAMILIES WHILE MINIMIZING THE TRAUMA AND DISLOCATION CAUSED TO HOMELESS INDIVIDUALS, FAMILIES, AND COMMUNITIES BY HOMELESSNESS; PROMOTE ACCESS TO AND EFFECTIVE UTILIZATION OF MAINSTREAM PROGRAMS BY HOMELESS INDIVIDUALS AND FAMILIES; AND OPTIMIZE SELF-SUFFICIENCY AMONG INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS. THE MOST RECENT COC AWARD ANNOUNCEMENT LISTING AWARDS BY STATE AND COC IS ACCESSIBLE AT HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/COC/AWARDS. SELECT THE LINK UNDER THE FUNDING AND AWARD INFORMATION SECTION FOR THE APPROPRIATE FISCAL YEAR.; ACTIVITIES TO BE PERFORMED: CONTINUUM OF CARE PROGRAM FUNDS MAY BE USED TO PAY FOR THE ELIGIBLE COSTS USED TO ESTABLISH AND OPERATE PROJECTS UNDER FIVE PROGRAM COMPONENTS: (1) PERMANENT HOUSING, WHICH INCLUDES PERMANENT SUPPORTIVE HOUSING FOR PERSONS WITH DISABILITIES, AND RAPID REHOUSING; (2) TRANSITIONAL HOUSING; (3) SUPPORTIVE SERVICES ONLY; (4) HOMELESS MANAGEMENT INFORMATION SYSTEMS (HMIS), AND (5) IN SOME CASES, HOMELESSNESS PREVENTION. THIRTEEN TYPES OF ASSISTANCE MAY BE PROVIDED THROUGH THE CONTINUUM OF CARE (COC) PROGRAM: (1) COC PLANNING ACTIVITIES/COSTS FOR DESIGNING AND CARRYING OUT A COLLABORATIVE PROCESS FOR THE DEVELOPMENT OF AN APPLICATION TO HUD; (2) UNITED FUNDING AGENCY (UFA) COSTS FOR FISCAL CONTROL AND ACCOUNTING NECESSARY TO ASSURE THE PROPER DISBURSAL OF, AND ACCOUNTING FOR, FEDERAL FUNDS AWARDED TO SUBRECIPIENTS UNDER THE CONTINUUM OF CARE PROGRAM, (3) ACQUISITION OF REAL PROPERTY (INCLUDING STRUCTURES) FOR USE IN THE PROVISION OF HOUSING OR SUPPORTIVE SERVICES; (4) REHABILITATION OF STRUCTURES TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (5) NEW CONSTRUCTION, INCLUDING THE BUILDING OF A NEW STRUCTURE OR BUILDING AN ADDITION TO AN EXISTING STRUCTURE FOR USE AS SUPPORTIVE HOUSING; (6) LEASING OF A STRUCTURE OR STRUCTURES, OR PORTIONS THEREOF, TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (7) RENTAL ASSISTANCE, WHICH MAY BE SHORT-TERM, MEDIUM-TERM, OR LONG-TERM, AS WELL AS TENANT-BASED, PROJECT-BASED, OR SPONSOR-BASED, FOR TRANSITIONAL OR PERMANENT HOUSING; (8) SUPPORTIVE SERVICES TO ASSIST PROGRAM PARTICIPANTS OBTAIN AND MAINTAIN HOUSING; (9) OPERATING COSTS OF SUPPORTIVE HOUSING; (10) COSTS OF IMPLEMENTING AND OPERATING HMIS; (11) PROJECT ADMINISTRATIVE COSTS; (12) RELOCATION COSTS; AND (13) INDIRECT COSTS IN ACCORDANCE WITH 2 CFR PARTS 200, AS APPLICABLE. IN ADDITION TO USING GRANT FUNDS FOR THE ELIGIBLE COSTS DESCRIBED ABOVE, RECIPIENTS AND SUBRECIPIENTS IN CONTINUUMS OF CARE DESIGNATED AS HIGH PERFORMING COMMUNITIES MAY ALSO USE GRANT FUNDS TO PROVIDE HOUSING RELOCATION AND STABILIZATION SERVICES AND SHORT- AND/OR MEDIUM-TERM RENTAL ASSISTANCE TO INDIVIDUALS AND FAMILIES AT RISK OF HOMELESSNESS AS SET FORTH IN 24 CFR 576.103 AND 24 CFR 576.104, IF NECESSARY TO PREVENT THE INDIVIDUAL OR FAMILY FROM BECOMING HOMELESS. LIMITATION ON USE OF FUNDS: NO ASSISTANCE PROVIDED UNDER PROGRAM (OR ANY STATE OR LOCAL GOVERNMENT FUNDS USED TO SUPPLEMENT THIS ASSISTANCE) MAY BE USED TO REPLACE STATE OR LOCAL FUNDS PREVIOUSLY USED, OR DESIGNATED FOR USE, TO ASSIST HOMELESS PERSONS OR PERSONS AT-RISK OF HOMELESSNESS.; EXPECTED OUTCOMES: DECREASE IN THE NUMBER INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS, MORE SPECIFICALLY USING PERFORMANCE INDICATORS SUCH AS THE LENGTH OF TIME HOMELESS, RETURNS TO HOMELESSNESS OVER TIME, AND EXITS TO PERMANENT HOUSING. COC PERFORMANCE PROFILE REPORTS CAN BE FOUND AT HTTPS://WWW.HUDEXCHANGE.INFO/PROGRAMS/COC/COC-PERFORMANCE-PROFILE-REPORTS/.; INTENDED BENEFICIARIES: INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

WE PROPOSE TO DEVELOP AN INTELLIGENT DATA ANALYSIS ENGINE THAT EXTENDS THE FUNCTIONALITY OF VIRTUAL OBSERVATORIES (VXOS) FROM DATA PORTAL TO SCIENCE

DEVELOPMENT OF A NOVEL NANOPARTICLE PYRIMIDINEDIONE VAGINAL POLYMERIC FILM AS AN

COMPETITIVE ABSTINENCE EDUCATION

CONTINUUM OF CARE PROGRAM

VHPL: VIRTUAL HYBRID PARTICLE LABORATORY FOR END-TO-END SIMULATION OF HIGH-BETA PLASMAS

CONTINUUM OF CARE PROGRAM

CONTINUUM OF CARE PROGRAM

CONTINUUM OF CARE PROGRAM

CONTINUUM OF CARE PROGRAM

CONTINUUM OF CARE PROGRAM

CRRSAA STUDENT EMERGENCY RELIEF GRANT

CONTINUUM OF CARE PROGRAM

CONTINUUM OF CARE PROGRAM

AUTOMATED SYSTEM TO IMPROVE COMPLIANCE TO DIABETIC RETINOPATHY SCREENING - SUMMARY THE OBJECTIVE OF THIS GRANT IS TO DEVELOP A FULLY AUTOMATED, ELECTRONIC HEALTH RECORD (EHR)-INTEGRABLE SOFTWARE APPLICATION, “DR-SCRN”, TO IMPROVE PATIENT’S COMPLIANCE TO DIABETIC RETINOPATHY (DR) SCREENING; BY PREDICTING A PATIENT’S RISK OF DR BASED ON THE ANALYSIS OF PATIENT’S OWN HEALTH DATA, AND EDUCATING THE PATIENT AS WELL AS NOTIFYING THE PROVIDER OF THE PATIENT’S DR RISK AND SCREENING NEEDS. DR-SCRN WILL ANALYZE THE READILY AVAILABLE HEALTH DATA OF PATIENT FROM EHR TO IDENTIFY AND PREDICT A TREND OF DR RISK OVER NEXT 3 YEARS. THE CORE INNOVATIONS OF THIS PROJECT ARE: A) DEMONSTRATE A FULLY AUTOMATED AND EHR-INTEGRATED TOOL TO PREDICT PATIENT’S DR RISK. B) IMPROVE SCREENING COMPLIANCE BY EDUCATING THE PATIENT WITH VISUAL AND NUMERICAL DATA, C) CALCULATE DR RISK BASED ON PATIENT’S HEALTH DATA, READILY AVAILABLE FROM EHR, D) DEVELOP SOFTWARE TO NOTIFY THE PROVIDER OF PATIENT’S SCREENING NEEDS AND TO ASSIST WITH PLANNING OF THE RECOMMENDED SCREENING SCHEDULE. THE MAIN MOTIVATION FOR DR-SCRN IS TO IMPROVE PATIENT’S COMPLIANCE TO DR SCREENING BY PREDICTING THEIR DR RISK USING THEIR OWN HEALTH DATA AND MAKING THEMSELVES AND THEIR CARE-PROVIDER AWARE OF THE POTENTIAL RISKS. DR IS PREVENTABLE WITH EARLY DETECTION THROUGH PERIODIC SCREENING AND TIMELY INTERVENTION. ALTHOUGH DR SCREENING EXAMINATIONS ARE READILY AVAILABLE, ONLY 18 TO 40% OF DIABETICS UNDERGO THE RECOMMENDED ANNUAL EYE EXAM. LOW COMPLIANCE TO DR SCREENING RESULTS IN VISION LOSS AND A $4.3 BILLION BURDEN TO THE US DUE TO VISION LOSS TREATMENT, SURGERY, AND DIMINISHED PRODUCTIVITY. LOW COMPLIANCE RESULTS FROM PATIENT’S IGNORANCE, FINANCIAL CONSTRAINTS, LACK OF ACCESS, AND LACK OF SYMPTOMS OR KNOWLEDGE THAT VISION LOSS WAS ASSOCIATED WITH DIABETES. PATIENT’S IGNORANCE AND LACK OF KNOWLEDGE HAVE BEEN THE MOST COMMON BARRIERS EVEN WHEN OTHERS ARE MINIMIZED. DR- SCRN ATTEMPTS TO IMPROVE THE COMPLIANCE BY PROMOTING THE EDUCATION OF PATIENTS AND PROVIDERS ON HEALTH CONDITION AND POTENTIAL RISKS AND PROVIDING A SEAMLESS SYSTEM FOR BOTH PATIENTS AND PROVIDERS TO MAKE THE SCREENING EXAMINATIONS EASILY ACCESSIBLE TO THE POPULATION IN NEED. THE OBJECTIVES OF THIS PROJECT WILL BE ACCOMPLISHED THROUGH THREE SPECIFIC AIMS. IN AIM 1, WE WILL DEVELOP AN AUTOMATIC ALGORITHM TO CALCULATE DR RISK BASED ON PATIENT’S HEALTH DATA, USING A RETROSPECTIVE DATASET OF N=5000 DIABETIC PATIENTS SELECTED FROM VISIONQUEST’S PROPRIETARY RETINAL SCREENING DATABASE. IN AIM 2, WE WILL DEVELOP AN EXTRAPOLATION OR TREND ESTIMATION ALGORITHM TO PREDICT FUTURE DR RISK BASED CURRENT DR RISK TREND, USING A SEPARATE LONGITUDINAL DATABASE OF N=2500 DIABETIC PATIENTS. IN AIM 3, WE WILL DEVELOP EDUCATIONAL MATERIAL FOR PATIENTS AND PROVIDERS TO IMPROVE SCREENING COMPLIANCE, THAT PROVIDES: A) NUMERICAL DR RISK PREDICTION OVER NEXT 3 YEARS, B) VISUAL REPRESENTATION OF HOW THE DR RISK MAY CHANGE, C) PROPOSED DR SCREENING SCHEDULE. FURTHER IN PHASE II, WE WILL PURSUE THREE OBJECTIVES: (1) A LARGE-SCALE, LONGITUDINAL DR SCREENING CLINICAL STUDY, (2) VALIDATION OF THE ALGORITHMS AND SOFTWARE APPLICATION USING THE CLINICAL STUDY DATA, (3) DEVELOPING A BRIDGING- SOFTWARE TO INTEGRATE DR-SCRN WITH AN EHR SYSTEM, TO DEMONSTRATE A COMPLETE APPLICATION PROTOTYPE. OUR PRIMARY MEASURE OF SUCCESS IN PHASE II WILL BE THE INTEGRATION OF DR-SCRN INTO THE EHR OF OUR EXISTING NETWORK OF CLINICS IN MEXICO AND AT RETINA GLOBAL, WHICH ARE ALREADY USING OUR AUTOMATIC DIABETIC RETINOPATHY SCREENING SYSTEM.

CONTINUUM OF CARE PROGRAM

CONTINUUM OF CARE PROGRAM

MAGNETIC RECONNECTION IS THE DOMINANT MECHANISM FOR THE SOLAR WIND MASS AND ENERGY ENTRY INTO THE EARTH'S MAGNETOSPHERE. CONSIDERABLE EFFORT HAS BEEN

CONTINUUM OF CARE PROGRAM

RECREATIONAL PROGRAMS

PHYSICS-BASED SIMULATOR TO TEACH HANDS-ON VASCULAR SURGICAL SKILLS

VA AWARDS GRANTS TO QUALIFYING ORGANIZATIONS TO PLAN, DEVELOP, MANAGE, AND IMPLEMENT PROGRAMS TO PROVIDE ADAPTIVE SPORTS OPPORTUNITIES FOR DISABLED VETERANS AND DISABLED MEMBERS OF THE ARMED FORCES AS AUTHORIZED UNDER 38 UNITED STATES CODE 521A.

CONTINUUM OF CARE PROGRAM

EYESTAR-BIO: SOFTWARE FOR ENHANCING DIGITAL BINOCULAR INDIRECT OPHTHALMOSCOPY EXAMINATIONS - SUMMARY THE GOAL OF THE PROPOSED PROJECT IS TO DEVELOP EYESTAR-BIO, A SUITE OF SOFTWARE TOOLS DESIGNED TO ENHANCE DIGITAL BINOCULAR INDIRECT OPHTHALMOSCOPY EXAMINATIONS (BIO), ONE OF THE MOST COMMON FORMS OF EXAMINATION OF THE RETINA. USING BIO, AN OPHTHALMOLOGIST CAN DETERMINE THE PRESENCE OF MULTIPLE RETINAL DISEASES SUCH AS DIABETIC RETINOPATHY, MACULAR DEGENERATION, AND RETINOPATHY OF PREMATURITY, AMONG OTHERS. THE TRADITIONAL BIO EXAM DOES NOT PRODUCE ANY VISUAL DOCUMENTATION. EYESTAR-BIO WILL FEATURE INNOVATIVE FEATURES THAT ARE NOT CURRENTLY OFFERED AS PART OF DIGITAL BIO EXAMS: (1) AUTOMATIC IMAGE QUALITY ASSESSMENT, (2) AUTOMATIC STITCHING TO CREATE A WIDE-FIELD VIEW OF THE RETINA, (3) LONGITUDINAL ANALYSIS, AND (4) AI-BASED DISEASE DETECTION. THIS PROJECT HAS AN $800M MARKET POTENTIAL AS BIO EXAMINATIONS REMAIN ONE OF THE MOST COMMON PROCEDURES FOR OPHTHALMOLOGISTS. THE GOALS OF THIS PHASE I PROJECT WILL BE ACCOMPLISHED VIA THREE SPECIFIC AIMS. AIM 1: IMPLEMENT SOFTWARE FOR AUTOMATIC IMAGE QUALITY ASSESSMENT OF DIGITAL BIO VIDEO FRAMES. AIM 2: DEVELOP IMAGE STITCHING METHODS TO GENERATE A WIDE FIELD VIEW OF THE RETINA USING THE BEST QUALITY FRAMES IN THE VIDEO. AIM 3: GENERATE IMAGES TO TRACK DIFFERENCES IN TIME DUE TO DISEASE PROGRESSION OR REGRESSION. THE EYESTAR-BIO SOFTWARE WILL BE LICENSED TO MANUFACTURERS OF DIGITAL BIO HEADSETS. FUTURE DEVELOPMENTS WILL INCLUDE REAL TIME IMPLEMENTATIONS OF EYESTAR-BIO AND THE ABILITY TO DIAGNOSE RETINAL DISEASE USING ARTIFICIAL INTELLIGENCE.

DEVELOPMENT OF TRANSDERMAL FILMS FOR THE THE DELIVERY OF HIV THERAPEUTICS

PURPOSE: TO PROMOTE ECONOMIC REVITALIZATION AND COMMUNITY DEVELOPMENT THROUGH TECHNICAL ASSISTANCE AWARDS TO BUILD THE CAPACITY OF COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS (CDFIS) AND EMERGING CDFIS. PLANNED ACTIVITIES TECHNICAL ASSISTANCE MUST BE USED FOR THE FOLLOWING ELIGIBLE ACTIVITIES SUBJECT TO THE APPLICABLE PROVISIONS OF THE UNIFORM REQUIREMENTS COMPENSATION PERSONAL SERVICES, COMPENSATION FRINGE BENEFITS, PROFESSIONAL SERVICE COSTS, TRAVEL COSTS, TRAINING AND EDUCATION COSTS, EQUIPMENT, SUPPLIES, AND INCORPORATION COSTS (SPONSORING ENTITIES ONLY). END GOALS: THE GOAL OF THE TECHNICAL ASSISTANCE IS TO BUILD CERTIFIED AND EMERGING CDFI’S ORGANIZATIONAL CAPACITY TO SERVE ELIGIBLE MARKETS AND/OR THEIR TARGET MARKETS, IN ORDER TO SERVE LOW INCOME PEOPLE, AND COMMUNITIES ACROSS THE NATION THAT LACK ADEQUATE ACCESS TO AFFORDABLE FINANCIAL PRODUCTS AND FINANCIAL SERVICES. BENEFICIARIES: PROFIT ORGANIZATION, PRIVATE NONPROFIT INSTITUTION/ORGANIZATION, OTHER PRIVATE INSTITUTION/ORGANIZATION INVESTMENT AREAS AND TARGETED POPULATIONS, AS DEFINED IN 12 C.F.R. 1805. SUBRECIPIENTS: THERE ARE NO SUBRECIPIENTS FOR THIS PROGRAM. BROADBAND: NOT APPLICABLE. REASON/PURPOSE OF MODIFICATION: NOT APPLICABLE.

IMPROVE EXISTING AIRPORT

AUGMENTED REALITY SYSTEM TO TEACH HEMOSTATIC AGENT USE IN HEMORRHAGE CONTROL

CONTINUUM OF CARE PROGRAM

CONTINUUM OF CARE PROGRAM

CONTINUUM OF CARE PROGRAM

DEVELOPMENT OF HIGH PERFORMANCE GAS-COUPLED ULTRASONIC TRANSDUCERS FOR INSPECTION OF UNPIGGABLE NATURAL GAS PIPELINES

ACCESS TO DIABETIC PERIPHERAL NEUROPATHY SCREENING FOR UNDERSERVED COMMUNITIES - SUMMARY HEALTH INEQUITIES POSE SERIOUS THREATS TO PEOPLE IN MINORITY GROUPS THROUGH EXPOSURE TO GREATER SOCIOECONOMIC RISKS AND LESS ACCESS TO HEALTHCARE. THE ECONOMIC BURDEN OF THESE INEQUITIES IS ESTIMATED IN THE HUNDREDS OF BILLIONS OF DOLLARS. MANY PEOPLE IN MINORITY GROUPS DO NOT KNOW THAT THEY HAVE DIABETES, BUT EVEN AMONG THOSE WHO ARE AWARE OF THEIR DIABETES, THE LACK OF COMPLIANCE WITH RECOMMENDED ANNUAL FOOT EXAMS IS WELL DOCUMENTED. A SHORTAGE OF PROVIDERS—FROM NURSES TO SPECIALISTS—ALSO CREATES BARRIERS TO PREVENTATIVE CARE AND TREATMENT, ESPECIALLY IN RURAL AREAS. YET RESEARCH HAS SHOWN THAT SCREENING CONTRIBUTES TO BETTER MEDICAL AND ECONOMIC OUTCOMES. DIABETIC PERIPHERAL NEUROPATHY (DPN) IS THE MOST COMMON COMORBIDITY OF DIABETES, BUT A LACK OF STANDARD SCREENING PROTOCOLS IS AN UNMET NEED IN RESOURCE LIMITED SETTINGS, AND NO SINGLE TOOL OBJECTIVELY MEASURES THE SYMPTOMS OF DPN. DRAWING FROM OUR EXPERIENCE IN DEVELOPING AND COMMERCIALIZING DIABETES-RELATED SCREENING TECHNOLOGIES, WE WILL CREATE AN ACCURATE, COMPREHENSIVE, AND INTEGRATED SYSTEM FOR THE QUANTITATIVE DETECTION OF DPN. THIS SYSTEM WILL INTEGRATE A LOW-COST SMARTPHONE WITH THERMAL-IMAGING CAPABILITIES AND AN AI DECISION SUPPORT SYSTEM FOR USE IN PRIMARY-CARE SETTINGS, AS WELL AS MOBILE SCREENING AND OUTREACH PROGRAMS. DPN- DOC WILL COMBINE THERMAL RESULTS WITH OTHER CRITICAL INFORMATION FROM A PATIENT’S CLINICAL EXAM AND MEDICAL RECORD TO GIVE THE PROVIDER A RECOMMENDATION FOR FURTHER CARE. AIM 1 – IDENTIFY A PORTABLE THERMAL IMAGING DEVICE. WE WILL SELECT A COMMERCIAL, OFF-THE-SHELF MOBILE PHONE–BASED THERMAL IMAGER THAT MEETS OUR COST AND PERFORMANCE REQUIREMENTS. AIM 2 – DEVELOP AN AI CLASSIFIER AND TEST A SMARTPHONE-BASED USER INTERFACE. USING OUR DATABASE OF CASES CONTAINING BOTH THERMAL AND CLINICAL DATA GATHERED DURING STANDARD DIABETIC FOOT EXAMS, WE WILL DEVELOP A CLASSIFIER ABLE TO INTEGRATE A VARIETY OF DATA POINTS AND PRODUCE A RECOMMENDATION FOR DPN CARE. WE WILL INCORPORATE THIS CLASSIFIER INTO OUR SMARTPHONE-BASED THERMAL IMAGING SYSTEM AND TEST THE EFFECTIVENESS OF THE NEW DEVICE AS COMPARED WITH STANDARD DIAGNOSTIC TESTS FOR DPN. AIM 3 – CREATE EDUCATIONAL MATERIALS THAT EMPHASIZE THE IMPORTANCE OF CONTINUOUS FOOT CARE AND PERIODIC FOOT EXAMS. IN COLLABORATION WITH GRAPHIC ARTISTS AND MEDICAL EXPERTS, WE WILL DEVELOP HIGHLY VISUAL, BILINGUAL (SPANISH/ENGLISH) EDUCATIONAL MATERIALS IN THE FORM OF A COMIC BOOK OR FOTONOVELA, A TECHNIQUE WE HAVE USED PREVIOUSLY TO ADDRESS LACK OF ADHERENCE TO EYECARE SCREENINGS. AIM 4 – EVALUATE USER EXPERIENCE OF SMARTPHONE-BASED DEVICE. WE WILL EVALUATE OUR SMARTPHONE-BASED SYSTEM AND EDUCATIONAL MATERIALS AMONG 10 POTENTIAL USERS WHO WORK WITH UNDERSERVED POPULATIONS TO GATHER THEIR FEEDBACK ON EASE OF USE AND COMMUNICABILITY.

CONTINUUM OF CARE PROGRAM

ADAPTABLE AND SCALABLE ELECTROPORATION FOR CELLULAR THERAPY - PROJECT SUMMARY CELLULAR THERAPIES HAVE DEMONSTRATED THE POTENTIAL TO TREAT A VARIETY OF INHERITED AND ACQUIRED DISEASES, BUT THE FIRST GENERATION OF APPROVED CELL THERAPIES RELY ON VIRAL VECTORS FOR CELLULAR REPROGRAMMING. VIRAL VECTORS ARE RECOGNIZED AS A BOTTLENECK IN THE DEVELOPMENT OF THESE THERAPIES AND OTHER DELIVERY METHODS, LIKE ELECTROPORATION, ARE BEING CLINICALLY INVESTIGATED. TO ADDRESS LIMITATIONS IN EXISTING ELECTROPORATION TECHNOLOGY, CYTEQUEST IS DEVELOPING A SIMPLE, SCALABLE ELECTROPORATION PLATFORM TO OPTIMIZE TRANSFECTION PARAMETERS AND DELIVER CARGO EFFICIENTLY AND REPRODUCIBLY AT HIGH THROUGHPUT. CYTEQUEST’S PLATFORM CONSISTS OF A PLANAR FLOW CHIP WITH A THIN SLAB GEOMETRY THAT ENSURES THAT CELLS ARE SUBJECT TO A UNIFORM ELECTRICAL FIELD FOR REPRODUCIBLE ELECTROPORATION. THE FLOW CELL GEOMETRY ALLOWS FOR SEAMLESS SCALING TO A HIGH- VOLUME SYSTEM FOR DELIVERY AT CLINICAL SCALE. THE KEY OBJECTIVES OF THIS PROPOSAL ARE TO: (1) DEMONSTRATE HIGH-EFFICIENCY DELIVERY OF CLINICALLY RELEVANT CARGO INCLUDING CRISPR/CAS9 RIBONUCLEOPROTEIN COMPLEXES TO PRIMARY HUMAN T CELLS, AND (2) CONSTRUCT A PROTOTYPE LARGE- VOLUME ELECTROPORATION FLOW SYSTEM COMPATIBLE WITH THE VOLUMETRIC THROUGHPUT REQUIRED FOR CELLULAR THERAPY IN A CLINICAL SETTING. CYTEQUEST WILL DEMONSTRATE THAT THE OPTIMIZED ELECTROPORATION PARAMETERS OF THE SMALL VOLUME SYSTEM CAN BE USED DIRECTLY IN THE HIGH-VOLUME SYSTEM WITH LESS THAN 5% VARIATION IN THE BIOMOLECULAR DELIVERY EFFICIENCY AND CELL VIABILITY. THE HIGH-VOLUME ELECTROPORATION FLOW SYSTEM CAN BE MANUFACTURED IN A PROCESS THAT IS COST-EFFECTIVE AND ROBUST. CYTEQUEST ULTIMATELY AIMS TO USE THIS NOVEL PLATFORM IN CONJUNCTION WITH CRISPR/CAS9 TECHNOLOGY AS A THERAPEUTIC APPLICATION FOR ADOPTIVE CELL THERAPY.

MECHANISM OF ACTION OF NOVEL DUAL ACTIING PYRIMIDINEDIONES

CONTINUUM OF CARE PROGRAM

CONTINUUM OF CARE PROGRAM

CONTINUUM OF CARE PROGRAM

HOMELESS ASSISTANCE

CONTINUUM OF CARE PROGRAM

CONTINUUM OF CARE PROGRAM

HEERF STUDENT PORTION - CARES RELIEF FUNDS TO ASSIST OUR STUDENTS IMPACTED BY COVID-19

HEERF - INSTITUTION PORTION

CONTINUUM OF CARE PROGRAM

AUTOMATED DIABETIC RETINOPATHY SCREENING SYSTEM

FY09 ONE-TIME GRANT COMPETITION - COMPETITION B - PROFESSIONAL, EMERGING YOUNG PROFESSIONALS PROGRAM

WASTE DISPOSAL GRANTS - REGULAR

EDUTAINMENT TOOL FOR INCREASING COMPLIANCE WITH DIABETIC RETINOPATHY SCREENING AN

ENDOVASCULAR SURGERY SIMULATION-BASED TRAINING PLATFORM

KNOWLEDGE QUEST WITH ITS PROJECT OPERATING GREEN LEAF LEARNING FARM GLLF IS FOCUSED ON EXPANDING ACCESS AND REACH TO LIMITED INCOME FAMILIES WITHIN THE SOUTH MEMPHIS COMMUNITY. ACTIVITIES INCLUDE ASSESSING CONSUMER NEEDS FOR FOOD FARMERS MARKETS AND FOOD ASSISTANCE PROGRAMS HIRING A PROGRAM MANAGER DEVELOPING RECRUITMENT AND PROMOTIONAL MATERIALS DESIGNING AN ADVERTISING AND PROMOTIONAL CAMPAIGN TO INCREASE AWARENESS ABOUT AVAILABLE FRESH LOCAL PRODUCE AND TO ENCOURAGE ENGAGEMENT IN FOODS EVENTS AND SALES FROM THE FARM AND LOCAL PRODUCERS.

ECONOMIC DEVELOPMENT INITIATIVE-SPECIAL PROJECT NEIGHBORHOOD INITIATIVE AND MISCELLANEOUS GRANTS

LAMP VALUE ADDED PRODUCER GRANT--MANDATORY

CONTINUUM OF CARE PROGRAM

MAGICMAT—MATERIALS GENOME AND INTEGRATED COMPUTATIONAL MATERIALS ENGINEERING TOOLKIT

DEVELOPMENT OF PYRIMIDINEDIONE NNRTIS WITH A HIGH GENETIC BARRIER TO RESISTANCE

CONTINUUM OF CARE PROGRAM

STTR PHASE I: BUILDING WITH CARBON: IMPROVING CONSTRUCTION MATERIALS WITH NANOCARBON ADDITIVES FROM NATURAL GAS

MATERIALS GENOME ENABLED DEVELOPMENT OF 3100ºF-CAPABLE MULTILAYER, MULTICOMPONENT THERMAL AND ENVIRONMENTAL BARRIER COATINGS FOR CMCS

SBIR PHASE I: ENHANCING STEM EDUCATION VIA VIRTUAL REALITY MEDICAL SIMULATION

COMPREHENSIVE EYE EVALUATION ALGORITHM: CEEVA

CONTINUUM OF CARE PROGRAM

IMPROVE EXISTING AIRPORT

CONTINUUM OF CARE PROGRAM

CONTINUUM OF CARE PROGRAM

GRAPHENE-ENRICHED HIERARCHICAL POLYMER ADDITIVES DERIVED FROM NATURAL GAS

GAS-TO-SOLIDS: UTILIZATION OF ASSOCIATED GAS FOR PRODUCTION OF HIGH VALUE CARBONS

CONDUCTOR BASE METAL DESIGN FOR CARBON INCORPORATION VIA SHAPE TECHNOLOGY

ICME-BASED DESIGN OF HSHC CU-ALLOYS FOR PARTICLE ACCELERATORS

QUANTITATIVE BIOMARKERS OF T1D PERIPHERAL NEUROPATHY USING FUNCTIONAL IMAGING

INCREASE AJLOUN YOUTH'S ACCESS TO EMPLOYMENT AND SELF-EMPLOYMENT IN IN THE TOURISM AND HOSPITALITY SECTORS

MR-PBS: MULTI-RESOLUTION PIC TECHNIQUE FOR POISSON-BASED SYSTEMS

TO SUPPORT DEVELOPMENT OF AN ARTS AND CULTURE CAMPUS ON A SECTION OF THE FORMER BETHLEHEM STEEL PLANT INCLUDING THE DESIGN CONSTRUCTION AND PLACEME

THIS PROJECT AIMS TO IMPROVE THE ECONOMIC PARTICIPATION OF 350 VULNERABLE FEMALE YOUTH IN THREE UNDERSERVED GOVERNORATES IN JORDAN THROUGH STABLE EMPLOYMENT IN THE PRIVATE SECTOR OR THROUGH SELF-EMPLOYMENT.

MACHINE LEARNING BASED SOFTWARE PACKAGE FOR REPRODUCIBLE DATA ANALYSIS FOR ELECTRON MICROSCOPY

STROKE RISK STRATIFICATION THROUGH PLAQUE MOTION ANALYSIS OF LONGITUDINAL CAROTID

NEW SBIR PHASE I 2009: COMPUTATIONAL DESIGN OF OXIDATION AND CREEP-RESISTANT NIOBIUM SUPERALLOYS FOR HIGH TEMPERATURE TURBINE APPLICATIONS; PI - ABHI

NEW SBIR PHASE I 2009: COMPUTATIONAL DESIGN OF COST-EFFECTIVE OXIDATION- AND CREEP-RESISTANT ALLOYS FOR COAL-FIRED POWER PLANTS; PI - JAMES WRIGHT

MAGNETIC RECONNECTION NEAR THE DREICER LIMIT

PORTABLE HAND-HELD NON-MYDRIATIC RETINAL CAMERA

PERSONAL ALCOHOL MANAGEMENT SYSTEM: PALMS MOBILE PLATFORM FOR ALCOHOL USE DISORDERS

STTR PHASE I: FORCE FEEDBACK CONTROL OF A SHAPE MEMORY ALLOY ACTIVE CATHETER FOR MINIMALLY INVASIVE MICRO-SURGERY

REAP RENEWABLE ENERGY SYSTEM (RES) GRANT UNRESTRICTED AMOUNT

GLOBAL DYNAMICS OF THE SOLAR CORONA&SOLAR WIND

FULLY AUTOMATIC ROP SCREENING SYSTEM: NEOSCAN

IMPROVE EXISTING AIRPORT

MOBILE EVALUATION DEVICE FOR MILD TRAUMATIC BRAIN INJURY

MICROVASCULAR FUNCTIONAL IMAGING SYSTEM

CHLORIDE INDUCED STRESS CORROSION CRACKING

INTEGRATED COMPUTATIONAL MATERIALS ENGINEERING (ICME) APPROACH TO DEVELOP BASE ALLOYS SUITABLE FOR COVETIC CONVERSION AND SCALE-UP

REAL-TIME FUNCTIONAL MRI WITH AUTOMATED PATTERN CLASSIFICATION

COMPREHENSIVE ASSESSMENT OF RETINAL VASCULATURE (CARV)

LOW-TEMPERATURE PLASMA SUBSTRATE-FREE PRODUCTION OF GRAPHENE FROM NATURAL GAS

IMPROVE EXISTING AIRPORT

COMPUTATIONAL MATERIALS DESIGN OF TUNGSTEN ALLOYS WITH IMPROVED FRACTURE TOUGHNESS AND A LOWERED DUCTILE TO BRITTLE TRANSITION TEMPERATURE (DBTT)

SEE SCHEDULE

PHYSICS-BASED HEAD AND NECK SURGICAL SIMULATION OF SOFT TISSUE MANIPULATION

LOW-COST ALLOYS FOR HIGH-TEMPERATURE SOFC SYSTEM COMPONENTS

MECHANISMS OF WAVE LIQUEFACTION CONVERSION OF COAL TO LIQUIDS FOR REACTOR REFINEMENT AND OPTIMIZATION

SMARTTOOL FOR ANOMALY DETECTION IN RADIOTHERAPY TREATMENT PLAN DATA

TAS::89 0227::TAS RECOVERY; NEW PHASE I SBIR: RECOVERY ACT; TITLE: RECOVERY ACT - COMPUTATIONAL DESIGN OF ADVANCED OXIDE-DISPERSION STRENGTHENED STEE

ESSENTIAL QUESTIONS OF SUSTAINABILITY (EQS): LEARNING FROM OUR AHUPUA`A - CLEAN WATER, OCEAN ENERGY AND SEA-LEVEL RISE