Fraunhofer Usa Inc

PLUG & PLAY SOLAR PV FOR AMERICAN HOMES

THE SGSS PROJECT (NASA/GSFC CODE 458) IS TASKED WITH DEVELOPING, IMPLEMENTING, AND SUPPORTING THE TRANSITION TO OPERATIONS OF A MODERNIZED GROUND SEG

MASS CUSTOMIZATION OF PREFABRICATED PANEL BLOCKS FOR DEEP WALL INSULATION RETROFITS

FRAUNHOFER USA SPACE NETWORK SOFTWARE AND SYSTEMS IMPROVEMENT APPLIED RESEARCH OVER THE NEXT FIVE

BACTERIAL DRUG SUSCEPTIBILITY IDENTIFICATION BY SURFACE ENHANCED RAMAN MICROSCOPY

FRAUNHOFER CSE

SUNDIAL - AN INTEGRATED SHINES SYSTEM TO ENABLE HIGH-PENETRATION FEEDER-LEVEL PV

NASA SOFTWARE AND SYSTEMS IMPROVEMENT APPLIED RESEARCHNASA IS CURRENTLY IMPLEMENTING AN AGENCY-WID

NASA SOFTWARE METRICS CAPABILITY SUPPORT

NEW AWARD DE-EE0009696 PROJECT TITLED: ''HIGH-FIDELITY SELF-LEARNING TOOL FOR RESIDENTIAL LOAD AND LOAD FLEXIBILITY FORECASTING''

MICROFLUIDIC PLATFORM FOR STRESS-INDUCED RAPID ANTIBIOTIC SUSCEPTIBILITY TESTING

TAS::89 0321::TAS NEW FINANCIAL AWARD FRAUNHOFER CENTER FOR SUSTAINABLE ENERGY

SPATIALLY MULTIPLEXED BIOGEL NANOSENSORS WITH BORON-DOPED DIAMOND MICROELECTRODE ARRAYS FOR HIV SELF-TESTING - PROJECT SUMMARY THE CLINICAL STUDIES DEMONSTRATING THAT WHEN PEOPLE MAINTAIN UNDETECTABLE LEVELS OF VIRAL LOADS, HIV CANNOT TRANSMIT PROVIDED AN EXCITING NEW DIRECTION FOR HIV MANAGEMENT. A CENTRAL PART OF HIV HEALTH CARE WILL BE TO DEVELOP THE TECHNOLOGY REQUIRED FOR HOME TESTING OF HIV VIRAL LOADS SIMILAR TO DIABETES MANAGEMENT. THERE ARE SEVERAL REQUIREMENTS FOR SUCH A HOME TEST. FIRST, SAMPLE PREPARATION OF VIRUS MUST CLEANLY ISOLATE VIRUS-LADEN PLASMA WITHOUT LYSING WHITE BLOOD CELLS OR REQUIRE ANY LAB EQUIPMENT. SECOND, THE TEST MUST STORE REAGENTS ON- CHIP AT AMBIENT CONDITIONS OVER LONG PERIODS. THIRD, THE TEST MUST PROVIDE ACCURATE AND IDEALLY, SEMI-QUANTITATIVE INFORMATION WITHOUT REQUIRING EXTENSIVE MANIPULATION, TRAINING, OR EXPENSIVE INSTRUMENTATION. CURRENT DIAGNOSTICS CANNOT MEET THESE REQUIREMENTS. THE HIGHEST VALUE TEST IS NUCLEIC ACID AMPLIFICATION BUT THE ENZYMES AND BUFFERS REQUIRE COLD CHAIN STORAGE, TRAINED PERSONNEL, AND FREQUENTLY, FLUORESCENCE-BASED INSTRUMENTATION. ANTIBODY- BASED TESTS FOR VIRAL CAPTURE ON LATERAL FLOW ARE HAMPERED BY LOWER ANALYTICAL SENSITIVITY AND SPECIFICITY VALUES, ARE NOT QUANTITATIVE, AND ARE HAMPERED BY PROTEIN RATHER THAN NUCLEIC ACID-BASED MANUFACTURING INFRASTRUCTURES. HERE WE PROPOSE THE INTEGRATION OF OUR NOVEL BIOGEL NANOSENSORS AND BORON-DOPED DIAMOND MICROELECTRODE ARRAYS TO DIRECTLY PROVIDE ACTIONABLE, SEMI-QUANTITATIVE, HIV VIRAL LOAD INFORMATION FOR THE HOME USER. OUR HYDROGEL ENCAPSULATES AND LOCKS IN NAAT TESTS IN AQUEOUS ENVIRONMENTS WITHOUT OIL OR MANUFACTURING ADDITIONAL COMPARTMENTS. THE GEL PROVIDES SAFE, ON-CHIP STORAGE OF REAGENTS AND CRITICALLY, IS PRINTABLE FOR RAPID FABRICATION OF ARRAYS FOR DIGITAL QUANTITATION. THE GEL IS ALSO SPECIFICALLY POSITIVELY CHARGED TO ATTRACT AND CONCENTRATE VIRAL GENOMES FROM THE RAW SAMPLE WHICH WOULD IMPROVE THE LOD95. IN OUR PROPOSED PLATFORM, A BORON-DOPED DIAMOND MICROELECTRODE UNDERLIES EACH SPOT IN THE ARRAY. THIS WILL PROVIDE AN INDIVIDUAL, ELECTROCHEMICAL READOUT FOR EVERY SPOT WHICH CAN BE INTERPRETED IN A DIGITAL FORMAT FOR POTENTIAL QUANTIFICATION. WITH THIS PLATFORM, THE USER SIMPLY ADDS BLOOD FROM A FINGERSTICK AND USES A MEMBRANE TO SEPARATE OUT THE PLASMA. A SECOND WICKING MEMBRANE WITH LYSIS REAGENTS DELIVERS VIRAL GENOMES TO THE BIOGEL NANOSENSOR ARRAY VIA LATERAL FLOW. TOGETHER, THE EASE OF USE, ON-CHIP STORAGE, CREATION OF A DIGITAL ELECTROCHEMICAL READOUT, AND COMPATIBILITY WITH MANUFACTURING INFRASTRUCTURES TO KEEP COSTS LOW YIELDS A PROMISING, VIABLE PLATFORM FOR HIV MANAGEMENT AT HOME.

PHYSICS-BASED INTERVAL DATA MODELS TO AUTOMATE AND SCALE HOME ENERGY PERFORMANCE EVALUATIONS

PHOTOVOLTAICS RESEARCH AND DEVELOPMENT (PVRD) 2: MODULES AND SYSTEMS

THE PURPOSE OF THIS PROJECT IS TO RESEARCH AND STUDY THE EFFECTIVENESS OF GRANTS ISSUED AND MANAGED BY NASA'S OFFICE OF SAFETY AND MISSION ASSURANCE

DEVELOPMENT OF A BIO-BASED, INEXPENSIVE, NONCORROSIVE, NONFLAMMABLE PHENOLIC FOAM FOR BUILDING INSULATION

THE PURPOSE OF THIS RESEARCH IS TO DEVELOP A TESTING APPROACH THAT DRAMATICALLY REDUCES TESTING TIME THROUGH PARALLELIZED AUTOMATED TESTING OF LARGE

BORON-DOPED DIAMOND ELECTRODE ARRAYS FOR MALARIA DETECTION IN SALIVA AND URINE

THE PURPOSE OF THIS PROJECT IS TO CONTINUE DEVELOPING, EVALUATING, AND TRANSFERRING STATE-OF-THE-ART SOFTWARE ENGINEERING TECHNOLOGIES IN SUPPORT OF

ERASE-PFAS: MECHANISTIC STUDY OF THE ELECTROCHEMICAL OXIDATION OF PER AND POLYFLUORINATED ALKYL SUBSTANCES TO GUIDE ELECTRODE DESIGN -PER- AND POLYFLUOROALKYL SUBSTANCES (PFAS), ALSO KNOWN AS ?FOREVER CHEMICALS,? ARE HARMFUL POLLUTANTS THAT DO NOT BREAK DOWN EASILY AND CAN CONTAMINATE DRINKING WATER. THIS PROJECT WILL IMPROVE A TREATMENT METHOD CALLED ELECTROCHEMICAL OXIDATION, WHICH USES ELECTRODES MADE OF DIAMOND TO DESTROY PFAS AND TURN THEM INTO SAFER COMPOUNDS. ALONG WITH SCIENTIFIC PROGRESS, THE PROJECT WILL SUPPORT STEM EDUCATION BY TRAINING BOTH UNDERGRADUATE AND GRADUATE STUDENTS AND OFFERING OUTREACH PROGRAMS AND WORKSHOPS. THESE EFFORTS WILL HELP PREPARE A SKILLED WORKFORCE TO ADDRESS MAJOR ENVIRONMENTAL PROBLEMS. THE PROJECT WILL ALSO SUPPORT GLOBAL TEAMWORK BY CONNECTING RESEARCHERS, STUDENTS, AND INDUSTRY PROFESSIONALS TO FIND BETTER WAYS TO HANDLE PFAS POLLUTION. THIS PROJECT AIMS TO ADVANCE THE SCIENTIFIC UNDERSTANDING AND PRACTICAL APPLICATION OF ELECTROCHEMICAL OXIDATION (EO) USING BORON-DOPED DIAMOND (BDD) ELECTRODES FOR THE DESTRUCTION OF PER- AND POLYFLUOROALKYL SUBSTANCES (PFAS); A CLASS OF ENVIRONMENTALLY PERSISTENT AND CHEMICALLY STABLE SYNTHETIC POLLUTANTS. PFAS, INCLUDING COMPOUNDS SUCH AS PERFLUOROOCTANOIC ACID (PFOA) AND PERFLUOROOCTANESULFONIC ACID (PFOS), ARE HIGHLY RESISTANT TO CONVENTIONAL CHEMICAL, PHYSICAL, AND BIOLOGICAL TREATMENT PROCESSES, MAKING THEIR REMOVAL FROM DRINKING WATER AND WASTEWATER PARTICULARLY CHALLENGING. THE PROPOSED RESEARCH SEEKS TO ADDRESS CURRENT LIMITATIONS IN EO TREATMENT BY INVESTIGATING THE MECHANISTIC BASIS OF PFAS DEGRADATION AT BDD ELECTRODE SURFACES, AND BY OPTIMIZING ELECTRODE DESIGN AND TREATMENT CELL CONFIGURATION TO IMPROVE PFAS MINERALIZATION EFFICIENCY. THE PROJECT IS STRUCTURED AROUND THE FOLLOWING TECHNICAL OBJECTIVES: (1) ELUCIDATE THE FUNDAMENTAL DEGRADATION MECHANISMS AND KINETICS OF PFAS DURING EO, WITH A FOCUS ON BOTH DIRECT ELECTRON TRANSFER AND INDIRECT OXIDATION PATHWAYS INVOLVING HYDROXYL RADICALS; (2) EVALUATE THE INFLUENCE OF OPERATIONAL PARAMETERS INCLUDING APPLIED POTENTIAL, CURRENT DENSITY, ELECTROLYTE COMPOSITION, FLOW DYNAMICS, AND ELECTRODE SURFACE MORPHOLOGY, ON PFAS DEGRADATION RATES AND ENERGY EFFICIENCY; (3) DESIGN AND FABRICATE NOVEL BDD ELECTRODE ARCHITECTURES AND FLOW-THROUGH REACTOR CONFIGURATIONS THAT ENHANCE MASS TRANSPORT, REDUCE ENERGY DEMAND, AND IMPROVE LONG-TERM SYSTEM TREATMENT STABILITY; AND (4) VALIDATE THE PERFORMANCE OF THE OPTIMIZED EO SYSTEM IN TREATING REAL-WORLD PFAS-CONTAMINATED WATER SAMPLES, SUCH AS GROUNDWATER, LANDFILL LEACHATE, AND ION EXCHANGE BRINE REJECT. TO ACHIEVE THESE OBJECTIVES, THE RESEARCH TEAM WILL CONDUCT SYSTEMATIC EO EXPERIMENTS USING MODEL PFAS COMPOUNDS UNDER CONTROLLED LABORATORY CONDITIONS. ADVANCED ANALYTICAL TECHNIQUES INCLUDING ION CHROMATOGRAPHY, HIGH-RESOLUTION MASS SPECTROMETRY, TOTAL ORGANIC FLUORINE ANALYSIS AND OTHERS WILL BE EMPLOYED TO TRACK PFAS DEGRADATION, QUANTIFY FLUORIDE RELEASE, IDENTIFY TRANSFORMATION PRODUCTS, AND ASSESS DEFLUORINATION EFFICIENCY. THESE DATA WILL BE USED TO CHARACTERIZE DEGRADATION PATHWAYS AND ASSESS TREATMENT EFFICIENCY. COMPLEMENTING THE EXPERIMENTAL STUDIES, COMPUTATIONAL MODELING AND QUANTUM CHEMICAL CALCULATIONS WILL SIMULATE PFAS INTERACTIONS WITH BDD SURFACES, PROVIDING INSIGHT INTO ACTIVATION ENERGIES, REACTIVE INTERMEDIATES, AND RATE-DETERMINING STEPS FOR BOTH DIRECT AND INDIRECT OXIDATION MECHANISMS. MODELING WILL ALSO BE USED TO OPTIMIZE ELECTRODE GEOMETRY AND REACTOR DESIGN, USING FLUID DYNAMICS AND ELECTRIC FIELD SIMULATIONS TO ENHANCE MASS TRANSFER AND REACTIVE SPECIES DISTRIBUTION. BASED ON THESE SIMULATIONS, PROTOTYPE BDD ELECTRODES WITH IMPROVED SURFACE AND ELECTRICAL PROPERTIES WILL BE FABRICATED AND INTEGRATED INTO CUSTOM-BUILT EO CELLS FOR PERFORMANCE TESTING. FOLLOWING LAB-SCALE OPTIMIZATION, THE NEW EO SYSTEMS WILL BE TESTED ON REAL WATER MATRICES WITH COMPLEX CHEMICAL BACKGROUNDS TO ASSESS TREATMENT ROBUSTNESS, MATRIX EFFECTS, AND SYSTEM SCALABILITY. THESE EVALUATIONS WILL PROVIDE A CRITICAL BRIDGE BETWEEN BENCH-SCALE RESEARCH AND FIELD-SCALE IMPLEMENTATION, ENSURING THAT THE DEVELOPED TECHNOLOGIES ARE VIABLE UNDER REALISTIC ENVIRONMENTAL CONDITIONS. THE BROADER IMPACT OF THIS PROJECT LIES IN TRANSLATING FUNDAMENTAL ELECTROCHEMICAL AND MATERIALS SCIENCE INSIGHTS INTO PRACTICAL TECHNOLOGIES FOR PFAS REMEDIATION ACROSS MUNICIPAL, INDUSTRIAL, AND AGRICULTURAL SETTINGS. THE RESEARCH OUTCOMES WILL INFORM STRUCTURE-REACTIVITY RELATIONSHIPS GOVERNING PFAS DEGRADATION ON BDD ELECTRODES, SUPPORT THE RATIONAL DESIGN OF HIGH-EFFICIENCY EO SYSTEMS, AND DEFINE OPERATIONAL STRATEGIES THAT MAXIMIZE PFAS DESTRUCTION WHILE MINIMIZING ENERGY CONSUMPTION AND UNDESIRABLE BYPRODUCT FORMATION. BY ADDRESSING A PRESSING WATER QUALITY CHALLENGE WITH A SCIENTIFICALLY RIGOROUS AND ENGINEERING-FORWARD APPROACH, THIS PROJECT WILL CONTRIBUTE TO THE DEVELOPMENT OF SUSTAINABLE, SCALABLE SOLUTIONS FOR MITIGATING PFAS CONTAMINATION AND PROTECTING PUBLIC HEALTH. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

SHF: MEDIUM: COLLABORATIVE RESEARCH: TRANSFER LEARNING IN SOFTWARE ENGINEERING

MULTITARGET-DISPLAY VIRUSLIKE PARTICLE-BASED VACCINE TO COMBAT LYME DISEASE

NOVEL METHODOLOGY FOR RAPID ANTIBIOTIC SUSCEPTIBIILITY TESTING IN S. AUREUS

CHAPS: CHARGE-ASSISTED PROTEIN SENSING

SBE TWC: SMALL: COLLABORATIVE: POCKET SECURITY - SMARTPHONE CYBERCRIME IN THE WILD

THE PURPOSE OF THIS PROJECT IS TO CONTINUE DEVELOPING EVALUATING AND TRANSFERRING STATE-OF-THE-ART SOFTWARE ENGINEERING TECHNOLOGIES AND SOFTWARE ASSURANCE METHODS IN SUPPORT OF NASA S OFFICE OF SAFETY AND MISSION ASSURANCE (OSMA) AND TO CONTINUALLY IMPROVE THE SOFTWARE ASSURANCE CAPABILITIES FOR NASA MISSIONS. AS MANY INNOVATIVE SOFTWARE ENGINEERING TECHNOLOGIES EMERGE NASA S INTEREST IN ADOPTING THEM FOR MISSIONS INCREASES IN CORRESPONDENCE. ADDITIONALLY NEW FOCUS AREAS SUCH AS CYBERSECURITY AUTONOMY AND ARTIFICIAL INTELLIGENCE HAVE BECOME MORE RELEVANT FOR NASA MISSIONS. CONSEQUENTLY THIS REQUIRES SOFTWARE ASSURANCE ENGINEERS (SAE) TO ADAPT AND DEVELOP SOFTWARE ASSURANCE METHODS THAT ARE CAPABLE OF SUPPORTING EVALUATING AND ASSURING NASA PROJECTS WITH CONFIDENCE.

CPS: FRONTIER: COLLABORATIVE RESEARCH: COMPOSITIONAL, APPROXIMATE, AND QUANTITATIVE REASONING FOR MEDICAL CYBER-PHYSICAL SYSTEMS

TAS::89 0331::TAS RECOVERY RECOVERY ACT: HIGH RATE LASER PITTING TECHNIQUE FOR SOLAR CELL TEXTURING

SPECIFICATION AND VERIFICATION OF MEDICAL DEVICE SOFTWARE

ARCHITECTURE DISCOVERY AND ANALYSIS OF REAL-TIME SOFTWARE

PLASMA ACTIVATED BIOCHAR FOR HIGH-EFFICIENCY CAPACITIVE DESALINATION

FORMAL APPROACHES TO VERIFYING MEDICAL DEVICE SOFTWARE