University Of Wyoming

WYOMING IDEA NETWORKS OF BIOMEDICAL RESEARCH EXCELLENCE

THE SWEETWATER CARBON STORAGE HUB (SCS HUB) WILL CAPTURE AND STORE CARBON FROM THE LARGEST PROPOSED DIRECT AIR CAPTURE (DAC) FACILITY IN THE ROCKY MOUNTAINS AND ONE OF THE NATION’S LARGEST TRONA (SODA ASH) MINES. THE PROJECT HAS FOUR OBJECTIVES: 1) BUILD THREE STRATIGRAPHIC CHARACTERIZATION WELLS TO UNDERGROUND INJECTION CONTROL (UIC) CLASS VI SPECIFICATIONS, WITH ATTENDANT PERMITTING AND SITE CHARACTERIZATION WHILE OBSERVING THE BUY AMERICA REQUIREMENTS FOR INFRASTRUCTURE PROJECTS, 2) COMPLETE CAPTURE & TRANSPORT STUDIES FOR TWO CARBON DIOXIDE (CO2) SOURCES (DAC & TRONA) AND THE PIPELINES TO CONNECT THESE SOURCES TO THE STORAGE HUB, 3) PREPARE COMMERCIAL PLANS TO GUIDE FUTURE WORK AND EVENTUAL OPERATIONS, SUCH AS RISK ASSESSMENT AND MITIGATION PLANS, A STORAGE FIELD DEVELOPMENT PLAN (SFDP), AND A COMMUNITY BENEFITS PLAN, AND, 4) COMPLETE A NATIONAL ENVIRONMENTAL POLICY ACT (NEPA) ANALYSES.

ASPHALT RESEARCH CONSORTIUM

WYOMING SENSORY BIOLOGY COBRE

GAINING EARLY AWARENESS AND READINESS FOR UNDERGRADUATE PROGRAMS (GEAR UP STATE)

GEAR UP WYOMING GRANT PROPOSAL UNDER FY2017 APPLICATION FOR GU STATE GRANTS

RII TRACK-1: ANTICIPATING THE CLIMATE-WATER TRANSITION AND CASCADING CHALLENGES TO SOCIO-ENVIRONMENTAL SYSTEMS IN AMERICA'S HEADWATERS -THE ANTICIPATING THE CLIMATE-WATER TRANSITION AND CASCADING CHALLENGES TO SOCIO-ENVIRONMENTAL SYSTEMS IN AMERICA'S HEADWATERS (WY-ACT) PROJECT WILL BRING TOGETHER RESEARCHERS FROM ACROSS WYOMING TO ADDRESS CRITICAL WATER RESOURCE CHALLENGES ARISING FROM CLIMATE CHANGE IN WYOMING AND THE ROCKY MOUNTAIN REGION. RESEARCHERS WILL IDENTIFY CHALLENGES, QUANTIFY RISKS, AND PREDICT SOCIETAL CONSEQUENCES OF SHIFTING CLIMATE CONDITIONS IN THE NATION?S CRITICAL HEADWATER AREAS, LIMITED BY UNCERTAINTIES IN HOW HYDROLOGICAL, ECOLOGICAL, AND SOCIOLOGICAL SYSTEMS INTERACT. WYOMING PROVIDES THE PREFECT SYSTEM TO STUDY THESE CLIMATE UNCERTAINTIES DUE TO ITS MOUNTAINOUS ECOSYSTEMS THAT LINK HIGH-ELEVATION NATIONAL PARKS AND OTHER FEDERAL LANDS TO A MOSAIC OF LOWER-ELEVATION TRIBAL, STATE, FEDERAL, AND PRIVATE LANDS AND WATERS. THE PROJECT IS DESIGNED TO CREATE SOLUTIONS TO STRAINS ON WATER AVAILABILITY RESULTING FROM CLIMATE CHANGE BY BUILDING TRUSTED NETWORKS WITH COMMUNITIES WHO WILL HAVE OPPORTUNITIES TO PROVIDE INPUT AS WELL AS HELP THE PROJECT TEAM FORMULATE OUTCOMES. THE PROJECT WILL PROVIDE SIGNIFICANT OPPORTUNITIES TO ENGAGE WYOMING COMMUNITIES IN STEM EDUCATION AND DEVELOP SIGNIFICANT COMPUTATIONAL RESOURCES FOR THE STATE. WY-ACT WILL BE ADMINISTERED BY THE UNIVERSITY OF WYOMING IN COLLABORATION WITH CENTRAL WYOMING COLLEGE AND WESTERN ECOSYSTEM TECHNOLOGY, A PRIVATE COMPANY. THE ANTICIPATING THE CLIMATE-WATER TRANSITION AND CASCADING CHALLENGES TO SOCIO-ENVIRONMENTAL SYSTEMS IN AMERICA'S HEADWATERS (WY-ACT) PROJECT WILL CREATE A WORLD-CLASS RESEARCH AND STEM TRAINING FACILITY THAT WILL ADDRESS CRITICAL WATER RESOURCE CHALLENGES ARISING FROM CLIMATE CHANGE IN WYOMING AND THE ROCKY MOUNTAIN REGION. WY-ACT?S GOALS ARE TO: 1) IDENTIFY CLIMATE-DRIVEN RISKS TO INTERACTING HYDROLOGICAL, ECOLOGICAL AND SOCIAL SYSTEMS; 2) REVEAL OPPORTUNITIES AND LIMITS FOR HOW COMMUNITIES AND STAKEHOLDERS RESPOND TO CLIMATE-INDUCED RISKS; 3) EVALUATE HOW THE PROCESS OF CO-PRODUCTION ENHANCES ADAPTIVE CAPACITY FOR KEY STAKEHOLDERS BY BUILDING TRUST IN NUMERICAL MODELS; AND 4) INTEGRATE THE UNDERSTANDING AND QUANTIFICATION OF RISKS AND UNCERTAINTIES ACROSS CLIMATE, HYDROLOGICAL, ECOLOGICAL, AND SOCIAL SYSTEMS THAT ARE INFORMED BY MODELS, OBSERVATIONS, AND STAKEHOLDER COLLABORATION. THESE PROJECT GOALS WILL BE ACHIEVED BY A TRANSDISCIPLINARY APPROACH THAT INCLUDES SOCIAL SCIENCE, CLIMATE SCIENCE, ECONOMICS, HYDROLOGY, DATA SCIENCE, ECOLOGY, AND COMMUNICATION. ADDITIONALLY, THIS PROJECT RECOGNIZES THE VALUE OF INVOLVING TRIBAL NATIONS IN CO-PRODUCTION, AND WILL INCLUDE INDIGENOUS KNOWLEDGE, PRACTITIONER KNOWLEDGE, EXPERIENTIAL KNOWLEDGE, AND SCIENTIFIC WAYS OF UNDERSTANDING TO INFORM AND ENHANCE THE UNDERSTANDING OF CHANGING WATER AVAILABILITY AND ITS IMPLICATIONS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

RII TRACK-1: LINKING MICROBIAL LIFE TO ECOSYSTEM SERVICES ACROSS WYOMING'S DYNAMIC LANDSCAPE

WATER IN A CHANGING WEST: THE WYOMING CENTER FOR ENVIRONMENTAL HYDROLOGY AND GEOPHYSICS

UNIVERSITY OF WYOMING CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND - INSTITUTIONAL COSTS

WYOMING KING AIR AS A NATIONAL FACILITY

WYOMING CARBONSAFE: ACCELERATING CCUS COMMERCIALIZATION AND DEPLOYMENT AT DRY FORK POWER STATION AND THE WYOMING INTEGRATED TEST CENTER

UNIVERSITY OF WYOMING - CARES ACT: HIGHER EDUCATION EMERGENCY RELIEF FUND

MID-SCALE RI-1 (M1:IP): THE NEXT GENERATION WYOMING KING AIR ATMOSPHERIC RESEARCH AIRCRAFT

WYOMING INTEGRATED TEST CENTER ENHANCEMENT. THIS PROJECT WILL DESIGN, CONSTRUCT AND TEST NEW FLUE GAS DILUTION, POLISHING AND SAMPLING SYSTEMS AND SUPPORTING STRUCTURES AT THE WYOMING INTEGRATED TEST CENTER (ITC) PROVIDING THE ABILITY TO SIMULATE MULTIPLE EMISSIONS SOURCES SIMULTANEOUSLY. THIS OBJECTIVE WILL EXPAND THE ABILITY OF THE ITC TO SUPPORT THE DEVELOPMENT OF NEW POST COMBUSTION CAPTURE TECHNOLOGIES AND HELP ADVANCE THE DOMESTIC CARBON MANAGEMENT GOALS OF NET-ZERO GREENHOUSE GAS TECHNOLOGIES AND ECONOMIES.

TAS::89 0211::TAS RECOVERY ACT: SITE CHARACTERIZATION OF PROMISING GEOLOGIC FORMATIONS FOR CO2 STORAGE NEW AWARD ENTITLED: RECOVERY ACT: SITE CHARAC

NUTRIENT RESTRICTION: PLACENTAL AND FETAL BRAIN AND RENAL OUTCOMES AND MECHANISM

UW NORTHERN ROCKIES REGIONAL INBRE

GEAR UP WYOMING GRANT PROPOSAL UNDER FY2024 APPLICATION FOR GU STATE GRANTS.

WYOMING KING AIR AS A NATIONAL FACILITY

WYOMING KING AIR AS A NATIONAL FACILITY

DE-FE0031624 FOR NEW AWARD ENTITLED COMMERCIAL-SCALE CARBON STORAGE COMPLEX FEASIBILITY STUDY AT DRY FORK STATION, WYOMING

THIS PROJECT WILL CONDUCT A FEASIBILITY ASSESSMENT OF THE TECHNICAL AND NON-TECHNICAL ASPECTS OF AN INTEGRATED CARBON CAPTURE AND STORAGE (CCS) PROJECT AT A SITE ADJACENT TO THE ECHO SPRINGS GAS PLANT IN CARBON COUNTY, WYOMING (THE PLANNED STORAGE FACILITY IS LOCATED NEAR THE BORDER OF CARBON AND SWEETWATER COUNTIES).

HERMISTON OREGON BASALT CARBON STORAGE ASSURANCE FACILITY ENTERPRISE THE PRIMARY OBJECTIVE OF THE HERMISTON OREGON BASALT CARBON STORAGE ASSURANCE FACILITY ENTERPRISE PROJECT IS TO ADDRESS RESEARCH GAPS CRUCIAL TO DE-RISKING AND DEMONSTRATING COMMERCIAL SCALE BASALT-HOSTED CARBON STORAGE, AND TO PROVIDE CRITICAL INFORMATION TO KEY STAKEHOLDERS AND DEVELOPERS SEEKING CARBON DIOXIDE STORAGE OPPORTUNITIES IN THE PACIFIC NORTHWEST OF THE UNITED STATES AND BEYOND.

DE-FE0031787 / BASE AWARD ''FIELD PILOT OF FOAM ASSISTED HYDROCARBON GAS INJECTION IN BAKKEN FORMATIONS'' UNIVERSITY OF WYOMING

REGIONAL SCALE COLLABORATION TO FACILITATE A DOMESTIC CRITICAL MINERALS FUTURE: CARBON ORE, RARE EARTH, AND CRITICAL MINERALS (CORE-CM) INITIATIVE THE PLANNED RESEARCH AND DEVELOPMENT WILL PROVIDE A REGIONAL SCALE UNDERSTANDING OF CRITICAL MINERALS PROSPECTIVITY AND PROVIDES INSIGHT INTO THE POTENTIAL MATERIALS THAT MAY BE SOURCED FROM DOMESTIC SECONDARY AND UNCONVENTIONAL FEEDSTOCKS ACROSS THE UNITED STATES. THE WORK WILL CONTRIBUTE TO THE DEVELOPMENT OF A FRAMEWORK THAT ADDRESSES ECONOMIC AND SUPPLY CHAIN BARRIERS, LEADS TO PILOT SCALE DEMOS, AND BROADEN SCOPE TO INCLUDE ADVANCED CARBON OR CRITICAL MINERAL BEARING MATERIAL PRODUCTS.

NEW AWARD DE-FE0031779 WITH UNIVERSITY OF WYOMING TITLED UNLOCKING THE TIGHT OIL RESERVOIRS OF THE POWDER RIVER BASIN, WYOMING

GAINING EARLY AWARENESS AND READINESS FOR UNDERGRADUATE PROGRAMS (GEAR-UP) - GEAR-UP STATE AWARD

HEALTH CENTER PROGRAM

METHODS DEVELOPMENT: DEVELOP AND VALIDATE DIAGNOSTIC TESTS FOR SARS-COV-2 AND OTHER CORONAVIRUSES IN WILDLIFE.

ART: RE-ENGINEERING TECHNOLOGY TRANSFER AT THE UNIVERSITY OF WYOMING -WYOMING IS A RURAL STATE WITH POPULATION DENSITY OF LESS THAN 6 PER SQUARE MILE. ITS ECONOMY IS HEAVILY DEPENDENT ON EXTRACTIVES, AGRICULTURE, AND TOURISM. THE UNIVERSITY OF WYOMING (UW) ? THE SOLE UNIVERSITY AND ACADEMIC RESEARCH INSTITUTION IN THE STATE ? HAS $139 MILLION IN RESEARCH EXPENDITURES IN 2022. BUT, BY ALL MARKERS, TRANSLATION OF RESEARCH LAGS IN COMPARISON WITH PEER UNIVERSITIES. BECAUSE UW IS THE STATE?S ONLY ACADEMIC RESEARCH ENTERPRISE, THE CREATION OF THE WYOMING TRANSLATION RESEARCH ACCELERATOR (WTRA) THROUGH THIS AWARD REPRESENTS A UNIQUE OPPORTUNITY FOR FEDERAL INVESTMENT TO IMPACT AN ENTIRE STATE. IT WILL TRANSFORM TRADITIONAL RESEARCH AND COMMERCIALIZATION INTO A HOLISTIC ACCELERATOR OF USE-INSPIRED RESEARCH AND DEVELOPMENT. THE PROJECT WILL DELIVER BENEFITS TO UNDER-SERVED POPULATIONS, AS WELL AS INDUSTRY AND COMMUNITY PARTNERS. EXPECTED OUTCOMES INCLUDE AN INCREASE IN INDUSTRY COLLABORATIONS AND STARTUPS, DIVERSIFICATION OF THE STATE?S ECONOMY, AND GREATER PREPAREDNESS OF GRADUATE STUDENTS AND POST-DOCTORAL STUDENTS TO ENTER INDUSTRY. THIS ART PROJECT WILL CATALYZE UNIVERSITY-WIDE CHANGE TO FOSTER AND SPEED UP THE PACE OF RESEARCH-ENABLED INNOVATION. THE EFFORT IS SUPPORTED AT THE HIGHEST LEVELS OF LEADERSHIP: UW?S PRESIDENT AND VP FOR RESEARCH SERVE AS CO-PRINCIPAL INVESTIGATORS. THIS PROJECT LEVERAGES THE NSF I-CORPS? MODEL, EXPANDING ON ITS PRINCIPLES TO RE-ENGINEER THE EXISTING RESEARCH AND COMMERCIALIZATION ENTERPRISE. EXPERIENTIAL TRAINING WILL BE CONDUCTED, WITH AN EMPHASIS ON GRADUATE STUDENTS AND POST-DOCTORAL RESEARCHERS. SEED TRANSLATIONAL RESEARCH PROJECTS WILL BE SELECTED TO HELP DIVERSIFY AND GROW THE WYOMING ECONOMY. WTRA WILL DEVELOP A MARKET-DRIVEN APPROACH THAT SUPPLANTS THE TRADITIONAL ?MARKET PUSH? MODEL. BASIC RESEARCH WILL STILL FLOURISH, BUT WITH AN EYE TO SOCIETAL BENEFITS BEYOND SCHOLARLY PUBLICATIONS. THIS PROJECT IS JOINTLY FUNDED BY THE TECHNOLOGY, INNOVATION, AND PARTNERSHIPS (TIP) DIRECTORATE, THE ESTABLISHED PROGRAM TO STIMULATE COMPETITIVE RESEARCH (EPSCOR), THE ADVANCE PROGRAM IN THE EDU DIRECTORATE, BIO, AND ENG DIRECTORATES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

PURPOSE: OVER THE LAST 9 MONTHS, NWRC HAS MADE SIGNIFICANT PROGRESS IN EXPANSION OF LABORATORY CAPACITY FOR MICROBIAL DIAGNOSTICS. CONTINUATION OF SUPPORT WILL ENSURE NWRC'S RECENTLY IMPROVED LABORATORY CAPACITY AND DIAGNOSTIC CAPABILITIES REMAIN FULLY FU

RII TRACK-2 FEC: HIGHLY PREDICTIVE, EXPLANATORY MODELS TO HARNESS THE LIFE SCIENCE DATA REVOLUTION

NEUROSCIENCE CENTER FOR BIOMEDICAL RESEARCH EXCELLENCE

TAS::89 0222::TAS; NEW; WYOMING DOE EPSCOR: QUANTUM DOT SENSITIZED SOLAR CELLS BASED ON TERNARY METAL OXIDE NANOWIRES; PI - THOMAS R. PARISH

AGROECOLOGICAL ANNOTATION OF GENE FUNCTION AND COMPUTATIONAL ANALYSIS OF GENE NETWORKS

ATMOSPHERE TO GRID: ADDRESSING BARRIERS TO ENERGY CONVERSION AND DELIVERY

EXPANDQISE: TRACK 2: DEVELOPING RESEARCH AND EDUCATION PROGRAMS IN QUANTUM INFORMATION SCIENCE AND ENGINEERING WITH RESEARCH ON LOCALLY TUNABLE 2D TOPOLOGICAL SUPERCONDUCTORS -NON-TECHNICAL DESCRIPTION: IN RECENT YEARS, REMARKABLE PROGRESS HAS BEEN MADE IN QUANTUM INFORMATION SCIENCE AND ENGINEERING (QISE), PARTICULARLY FOR QUANTUM COMPUTING, QUANTUM SENSING, QUANTUM COMMUNICATIONS AND QUANTUM SIMULATIONS. WITH THE RAPIDLY EXPANDING INTEREST AND INVESTMENT, EDUCATION AND WORKFORCE DEVELOPMENT EFFORTS IN QISE ARE BECOMING INCREASINGLY CRITICAL, PARTICULARLY IN THE COUNTRY'S RURAL REGIONS. THIS FIVE-YEAR PROJECT IS DESIGNED TO DEVELOP RESEARCH AND EDUCATION CAPACITIES IN THE EMERGING FIELD OF QISE AT THE UNIVERSITY OF WYOMING THROUGH CLOSE COLLABORATION WITH PURDUE UNIVERSITY, WHERE QISE RESEARCH AND EDUCATION PROGRAMS ARE ESTABLISHED AND PRODUCTIVE. THIS PROJECT CONTAINS TWO ESSENTIAL COMPONENTS: 1) CONDUCTING A CUTTING-EDGE RESEARCH PROJECT OF EXPLORING EXOTIC PROPERTIES (FOR EXAMPLE, TOPOLOGICAL SUPERCONDUCTIVITY) OF TWO-DIMENSIONAL (2D) QUANTUM MATERIALS FOR NEXT-GENERATION QUANTUM COMPUTERS; AND 2) DEVELOPING EDUCATION PROGRAMS AT BOTH UNDERGRADUATE AND GRADUATE LEVELS FOR FUTURE WORKFORCE IN QISE AT THE UNIVERSITY OF WYOMING. THIS COLLABORATIVE EFFORT IS EXPECTED TO BREAK THE EXISTING BARRIER, INCREASE PARTICIPATION, AND BUILD THE CRITICAL MASS OF RESEARCH AND EDUCATION IN QISE IN WYOMING, THUS MAINTAINING ITS ECONOMIC COMPETITIVENESS AND FUELING TRANSFORMATIVE SCIENTIFIC ADVANCEMENT. TECHNICAL DESCRIPTION: DEVELOPING NOVEL QUANTUM TECHNOLOGIES FOR FUTURE ADVANCED COMPUTING HAS BEEN AN URGENT NEED AND A TECHNOLOGY RACE WORLDWIDE. TO MAINTAIN ECONOMIC COMPETITIVENESS, SUSTAIN NATIONAL SECURITY, AND FUEL TRANSFORMATIVE SCIENTIFIC ADVANCEMENT IN A TIME OF RAPIDLY EXPANDING INTEREST AND INVESTMENT IN QISE, RELEVANT EDUCATION AND SUSTAINABLE WORKFORCE DEVELOPMENT EFFORTS ARE BECOMING INCREASINGLY CRITICAL. IN COLLABORATION WITH PURDUE UNIVERSITY, WHERE QISE RESEARCH AND EDUCATION PROGRAMS ARE ESTABLISHED AND PRODUCTIVE, A TEAM FROM THE UNIVERSITY OF WYOMING IS UNDERTAKING THIS IMPORTANT AND CRITICAL TASK. THIS COLLABORATIVE ACTIVITY DEVELOPS METHODOLOGIES TO MANIPULATE THE COUPLING BETWEEN ELECTRONIC, STRUCTURAL, AND TOPOLOGICAL DEGREES OF FREEDOM IN ATOMICALLY THIN TOPOLOGICAL SUPERCONDUCTORS AND TO DESIGN AND FABRICATE NOVEL TOPOLOGICAL JOSEPHSON JUNCTION ARCHITECTURES FOR FUTURE FAULT-TOLERANT TOPOLOGICAL QUANTUM COMPUTING. THEORETICAL ANALYSIS AND MODELING FURTHER ENABLE THE FUNDAMENTAL UNDERSTANDING OF THE PHYSICS OF TOPOLOGICAL SUPERCONDUCTIVITY AND MAJORANA FERMIONS AT THE 2D LIMIT. THIS COLLABORATIVE PROJECT ALSO ESTABLISHES THE NECESSARY INFRASTRUCTURES FOR DEVELOPING THE FUTURE WORKFORCE IN QISE AT THE UNIVERSITY OF WYOMING BY DEVELOPING NEW DEGREE PROGRAMS AT BOTH THE UNDERGRADUATE AND GRADUATE LEVELS, RECRUITING NEW FACULTY, AND CONSTRUCTING STATE-OF-THE-ART FACILITIES. THE TEAM FURTHER PURSUES MUTUAL INTERACTIONS WITH INDUSTRY AND NATIONAL LABORATORY PARTNERS TO OFFER RESEARCH/EDUCATION OPPORTUNITIES FOR BOTH UNDERGRADUATE AND GRADUATE STUDENTS. THE ACADEMIC DEGREE PROGRAMS AND WORKFORCE DEVELOPMENT PLAN PROVIDE UNIQUE RESEARCH AND EDUCATIONAL EXPERIENCES FOR PHYSICS, CHEMISTRY, MATHEMATICS, AND ELECTRICAL ENGINEERING AND COMPUTER SCIENCE STUDENTS AT THE UNIVERSITY OF WYOMING. THIS COLLABORATIVE EFFORT IS EXPECTED TO SET UP A NATIONAL EDUCATIONAL MODEL FOR EXPANDING QISE-RELATED RESEARCH AND EDUCATION ACTIVITIES IN THE COUNTRY?S RURAL REGIONS AND/OR INSTITUTIONS WITH NO OR UNDERDEVELOPED QISE PROGRAMS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

INTEGRATION OF PRODUCED WATER THERMAL DESALINATION AND STEAM METHANE REFORMING FOR EFFICIENT HYDROGEN PRODUCTION THE PROJECT WILL DESIGN, BUILD, DEMONSTRATE, AND FIELD-TEST A SUPERCRITICAL WATER DESALINATION AND OXIDATION (SCWDO) UNIT INTEGRATED WITH A STEAM METHANE REFORMING (SMR) UNIT. THE SCWDO USES HEAT TO REMOVE SALTS, METALS, AND ORGANIC MOLECULES FROM PRODUCED WATER FROM OIL AND GAS WELLS AND THEN THE SMR COMBINES THIS PURIFIED WATER WITH METHANE TO PRODUCE HYDROGEN.

WESTERN RESEARCH INSTITUTE (WRI) COOPERATIVE RESEARCH AND DEVELOPMENT PROGRAM FOR FOSSIL ENERGY MODIFICATION 012 THE PURPOSE OF THIS MODIFICATION IS

DOE WRI COOPERATIVE RESEARCH AND DEVELOPMENT PROGRAM FOR FOSSIL ENERGY RELATED RESOURCES

WYOMING TECHNICAL ASSISTANCE COLLABORATION FOR ENERGY MANAGEMENT (WYTAC-EM) THE OBJECTIVE OF THIS PROJECT IS TO ENABLE RAPID AND RELIABLE ACCESS TO INFORMATION, TOOLS, AND BEST PRACTICES FOR CURRENT AND POTENTIAL PROJECT DEVELOPERS, AND REGULATORS SEEKING TO DEVELOP AND DEPLOY PROJECTS IN THE STATE OF WYOMING.

THE PRIMARY GOALS AND MISSION OF THE WYOMING NASA SPACE GRANT CONSORTIUM (WSGC) BASED ON NASA S 2018 STRATEGIC PLAN MISSION DIRECTORATE PRIORITIES AND OFFICE OF STEM ENGAGEMENT GOALS USING EVIDENCE-BASED PRACTICES ARE: 1) TO PROMOTE A STRONG ED

ASPHALT RESEARCH CONSORTIUM

WYOMING SPACE CONSORTIUM

THE WELCOME PROJECT WYOMING EDUCATORS LEARNING THROUGH CREDENTIALING AND OUTREACH FOR MULTILINGUAL EDUCATION

WYOMING NSF EPSCOR RESEARCH INFRASTRUCTURE IMPROVEMENT

CREATING THE FRAMEWORK FOR THE NEXT GENERATION ENERGY EXASCALE EARTH SYSTEM MODEL (E3SM) AT PROCEED (PERTURBED PHYSICS ENSEMBLE REGRESSION OPTIMIZATION CENTER FOR ESM EVALUATION AND DEVELOPMENT)

GERIATRICS WORKFORCE ENHANCEMENT PROGRAM

EQUIPMENT: MRI: TRACK 2 ACQUISITION OF AN ADVANCED INFRASTRUCTURE TO ACCELERATE IMPACT OF AI THROUGH APPLICATIONS AND INNOVATION FOR WYOMING (AI4WY) -THE AI4WY (ACQUISITION OF AN ADVANCED INFRASTRUCTURE TO ACCELERATE IMPACT OF AI THROUGH APPLICATIONS AND INNOVATION FOR WYOMING) PROJECT WILL ACQUIRE A STATE-OF-THE-ART HIGH-PERFORMANCE COMPUTING (HPC) SYSTEM, SIGNIFICANTLY ADVANCING THE APPLICATION AND INNOVATION OF ARTIFICIAL INTELLIGENCE AND COMPUTATIONAL SCIENCE ACROSS THE UNIVERSITY OF WYOMING AND THE ROCKY MOUNTAIN REGION. THE INSTRUMENT WILL ENABLE THE ADOPTION AND DEVELOPMENT OF SCALABLE SCIENTIFIC SOFTWARE FOR ADDRESSING GRAND-CHALLENGE PROBLEMS CHARACTERIZED BY BIG DATA AND INTEGRATED MODELING. THIS INITIATIVE STRIVES TO PROMOTE SCIENTIFIC PROGRESS AND TACKLE PRESSING ISSUES IN FOUR EMPHASIZED RESEARCH DOMAINS WITH REGIONAL AND NATIONAL IMPACT: ENVIRONMENT, AGRICULTURE, SOCIETY, AND ENERGY. BY PROVIDING RESEARCHERS WITH ACCESS TO CUTTING-EDGE COMPUTING RESOURCES, AI4WY FACILITATES GROUNDBREAKING RESEARCH AND EDUCATION, FOSTERING COLLABORATIONS AMONG UNIVERSITIES AND EXPANDING OPPORTUNITIES TO SERVE THE NEEDS OF ALL USERS, INCLUDING THOSE FROM UNDER-SERVED INSTITUTIONS, PROMOTING THE HPC ECOSYSTEM ACROSS THE ROCKY MOUNTAIN REGION. THE AI4WY PROJECT WILL UTILIZE A SPECIALIZED HPC SYSTEM FEATURING NVIDIA DGX GH200 GRACE HOPPER SUPERCHIPS, INTERCONNECTED WITH NVIDIA INFINIBAND AND NVLINK, AND EQUIPPED WITH 400 TERABYTES OF DATA STORAGE. THIS INFRASTRUCTURE ADDRESSES CRITICAL COMPUTING CHALLENGES RELATED TO DATA MOVEMENT AND ENERGY CONSUMPTION THROUGH THE GRACE HOPPER ARCHITECTURE, WHICH INTEGRATES HIGH-BANDWIDTH COHERENT DATA TRANSFERS BETWEEN CPU AND GPU. AI4WY WILL GERMINATE COLLABORATIVE HPC RESEARCH BY SERVING RESEARCHERS AND EDUCATORS AT THE UNIVERSITY OF WYOMING, COLORADO STATE UNIVERSITY (CSU), AND THE ROCKY MOUNTAIN ADVANCED COMPUTING CONSORTIUM (RMACC). THROUGH THIS PROGRAM, THE UNIVERSITY OF WYOMING AND COLORADO STATE UNIVERSITY ARE ACTIVELY ESTABLISHING FORMAL RESEARCH AND TRAINING COLLABORATIONS TO FOCUS ON INTER-STATE RESEARCH PROBLEMS, INCLUDING AGRICULTURE, PUBLIC HEALTH, SOCIETY, ENERGY, AND TOURISM. A DEDICATED ALLOCATION OF 15% OF COMPUTING RESOURCES ON THE PROPOSED INSTRUMENT TO CSU FOR RESEARCH AND TRAINING WILL PROMOTE THESE EFFORTS. MORE BROADLY, THE AI4WY PROJECT WILL ALSO PROVIDE A 10% RESOURCE ALLOCATION TO THE ROCKY MOUNTAIN ADVANCED COMPUTING CONSORTIUM (RMACC), GIVING ACCESS TO 33 INSTITUTIONS IN THE WEST, INCLUDING SOME 45,000 ACADEMIC STAFF, 160,000 GRADUATES AND 540,000 UNDERGRADUATE STUDENTS, AND 15 NON-R1 UNIVERSITIES. THIS PROJECT IS JOINTLY FUNDED BY OFFICE OF INTEGRATIVE ACTIVITIES (OIA), THE ESTABLISHED PROGRAM TO STIMULATE COMPETITIVE RESEARCH (EPSCOR), DIRECTORATE FOR COMPUTER AND INFORMATION SCIENCE AND ENGINEERING (CISE), AND OFFICE OF ADVANCED CYBERINFRASTRUCTURE (OAC). THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

IN VIVO REGULATION OF THE EXTRACELLULAR MATRIX

TAS::89 0213::TAS NEW AWARD TO WESTERN RESEARCH INSTITUTE ENTITLED "PILOT SCALE WATER GAS SHIFT - MEMBRANE DEVICE FOR HYDROGEN FROM COAL."

STATE MATERNAL HEALTH INNOVATION PROGRAM

NEUROSCIENCE CORE CENTER

PURPOSE: EFFECTIVE APRIL 1, 2022 VIA THIS COOPERATIVE AGREEMENT THIS RECIPIENT WAS GRANTED FUNDING TO OPERATE AN MEP CENTER IN THE STATE OF WYOMING. THE PURPOSE OF THIS AWARD IS TO PROVIDE MANUFACTURING EXTENSION SERVICES TO PRIMARILY SMALL AND MEDIUM-SIZED MANUFACTURERS IN THE STATE OF WYOMING. ACTIVITIES TO BE PERFORMED: THROUGH ITS COLLABORATIONS AT THE FEDERAL, STATE AND LOCAL LEVEL, AS IT EVOLVES TO NIST 2.0, MANUFACTURING-WORKS WILL PURSUE THREE BROAD STRATEGIC APPROACHES:1) ADAPT THE M-W BUSINESS MODEL TO PROVIDE NEW PRODUCTS AND SERVICES, 2) CONTINUE TO PROVIDE TRADITIONAL MEP SERVICES, FOCUSED ON FIVE KEY AREAS, AND 3) LEVERAGE ITS RESOURCES BY ENHANCING CURRENT PARTNERSHIPS AND FOSTERING NEW ONES. THESE THREE APPROACHES HAVE BEEN DEVELOPED BY THE CURRENT TEAM DURING THE PAST YEAR?S TRANSITION PERIOD. GOING FORWARD, M-W WILL CONSULT WITH ITS NEWLY EXPANDED ADVISORY BOARD TO REVIEW AND EXTEND THIS STRATEGY FOR THE LONGER TERM.EXPECTED OUTCOMES: THE CENTER WILL STRENGTHEN MANUFACTURING IN WYOMING BY COMMUNICATING AND DELIVERING/MAKING NEW TECHNOLOGIES AVAILABLE TO MANUFACTURERS FOR GROWTH AND PRODUCTIVITY. THE CENTER BUILDS AWARENESS OF MANUFACTURING CAREERS WITH THEIR PROGRAMS/PRESENTATIONS. PROVIDE SERVICES THAT ADDRESS WORKFORCE BEHAVIORS THAT IMPACT PRODUCTIVITY AND BUSINESS PERFORMANCE ISSUES. THEIR LEADERSHIP DEVELOPMENT AND SUCCESSION PLAN DEVELOPMENT HELPS MANUFACTURERS CONTINUE TO GROW AND BE VIABLE. THE CENTERS GOAL IS TO ASSIST MANUFACTURERS IN THE ACHIEVEMENT OF HIGHER PERFORMANCE AND IMPROVED GLOBAL COMPETITIVENESS. INTENDED BENEFICIARIES: SMALL AND MEDIUM-SIZED MANUFACTURERS IN THE STATE OF WYOMING.SUBRECIPIENT ACTIVITIES: THE RECIPIENT DOES NOT PLAN TO UTILIZE SUBAWARDS TO PARTICIPATE IN CONDUCTING THE ACTIVITIES RELATED TO WORK FORCE DEVELOPMENT AND TECHNICAL ASSISTANCE MANUFACTURER

RESEARCH: PREDICTING GENOTYPIC VARIATION IN GROWTH AND YIELD UNDER ABIOTIC STRESS THROUGH BIOPHYSICAL PROCESS MODELING

GERIATRICS WORKFORCE ENHANCEMENT PROGRAM

A SYSTEMS ANALYSIS OF PLANT GROWTH PROMOTION BY THE RHIZOSPHERE MICROBIOME

GROWING RESILIENCE IN WIND RIVER INDIAN RESERVATION: AN RCT ON GARDENS FOR HEALTH

DEVELOPMENTAL FUNCTION OF RB FAMILY PROTEINS

UNIVERSITY CENTERS FOR EXCELLENCE IN DEVELOPMENTAL DISABILITIES EDUCATION, RESEARCH AND SERVICE

GERIATRICS WORKFORCE ENHANCEMENT PROGRAM

TAS::89 0213::TAS NEW AWARD ENTITLED MAXIMIZATION OF PERMANENT TRAPPING OF CO2 AND CO-CONTAMINANTS IN THE HIGHEST-POROSITY FORMATIONS OF THE ROCK SPR

UNIVERSITY OF WYOMING EDUCATIONAL OPPORTUNITY CENTERS - 1 (EOC-1)

UNIVERSITY OF WYOMING UPWARD BOUND

THE ENERGY -WATER RESOURCES INTERFACE: A MODEL FOR COMPLEX SYSTEMS ANALYSIS IN RURAL WYOMING MIDDLE SCHOOLS

DE-FE0031738: DEVELOPING CARBON DIOXIDE-ENHANCED OIL RECOVERY AND ASSOCIATED STORAGE WITHIN THE RESIDUAL OIL ZONE FAIRWAYS OF THE POWDER RIVER BASIN WYOMING: NEW AWARD

UNIVERSITY CENTER OF EXCELLENCE IN DEVELOPMENTAL DISABILITIES

IMPACT OF FC N-GLYCAN STRUCTURE ON HIV-SPECIFIC ANTIBODY FUNCTIONS

DEVELOPMENTAL PROGRAMMING BY MISMATCH OF PRE-AND POSTNATAL NURTITION

NSF-UNIVERSITY OF WYOMING KING AIR RESEARCH AIRCRAFT OPERATIONS & MAINTENANCE -THE NATIONAL SCIENCE FOUNDATION ? UNIVERSITY OF WYOMING KING AIR (NSF UWKA) RESEARCH AIRCRAFT ENABLES THE STUDY OF A VARIETY OF ATMOSPHERIC PROCESSES RELATED TO CLOUDS, PRECIPITATION, CHEMISTRY, AND THE STRUCTURE OF THE ATMOSPHERE CLOSEST TO EARTH?S SURFACE. THIS AWARD ENSURES THE AVAILABILITY OF THE NSF UWKA TO THE RESEARCH COMMUNITY BY SUPPORTING THE OPERATIONS AND MAINTENANCE OF THE AIRCRAFT AND ASSOCIATED INSTRUMENTS. THE TYPES OF RESEARCH THAT THE NSF UWKA SPECIALIZES IN ARE DIRECTLY RELEVANT TO CRITICAL TOPICS IN WEATHER AND AIR QUALITY THAT IMPACT PUBLIC SAFETY, HUMAN HEALTH, AND ECONOMIC SECURITY. THE FACILITY ALSO PLAYS AN IMPORTANT ROLE, AS A UNIQUE UNIVERSITY-BASED ATMOSPHERIC RESEARCH AIRCRAFT, IN PROVIDING TRAINING FOR THE NEXT GENERATION OF AIRBORNE RESEARCH SCIENTISTS. THIS PROJECT PROVIDES FOR THE MANAGEMENT, STAFFING, UPGRADING, TESTING, OPERATION AND MAINTENANCE OF THE NSF UWKA AIRCRAFT AND ASSOCIATED INSTRUMENTATION AND SOFTWARE. THE NSF UWKA IS AN AGILE PLATFORM, CAPABLE FOR USE IN STUDIES RANGING FROM CLOUD-AEROSOL INTERACTION, TO BOUNDARY-LAYER DYNAMICS, AIR QUALITY, CLOUD AND PRECIPITATION PHYSICS, AND CHEMISTRY OF TRACE GASES AND AEROSOL. A NEW KING AIR 350I AIRFRAME WAS RECENTLY MODIFIED UNDER NSF FUNDING TO PROVIDE THE COMMUNITY WITH A MORE CAPABLE AIRCRAFT THAT HAS A HIGHER CEILING, LONGER FLIGHT DURATION, AND MORE POWER FOR INSTRUMENTS THAN THE PRIOR PLATFORM. THE PRIMARY GOALS OF THIS PROJECT ARE TO: 1) ENSURE THAT THE NSF UWKA AND ASSOCIATED INSTRUMENTATION ARE AVAILABLE FOR DEPLOYMENT FOR NSF-SUPPORTED RESEARCHERS, 2) ENSURE THAT THE KING AIR FACILITY MEASUREMENT CAPABILITIES AND ASSOCIATED DATA PRODUCTS ARE OF HIGH QUALITY AND RESPONSIVE TO THE EVOLVING RESEARCH NEEDS AND INTERESTS OF THE NSF-FUNDED COMMUNITY, AND 3) CONTINUE TO DEVELOP AND ENHANCE OUTREACH AND EDUCATION EFFORTS TOWARDS LOWERING THE BARRIERS OF ACCESS TO ADVANCED AIRBORNE ATMOSPHERIC MEASUREMENTS THEREBY MAKING THE NSF UWKA THE PLATFORM OF CHOICE FOR TRAINING THE NEXT GENERATION OF AIRBORNE ATMOSPHERIC SCIENTISTS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

RWO208: MAPPING BIG GAME MIGRATION CORRIDORS IN WYOMING AND OTHER WESTERN STATES: USGS IMPLEMENTATION OF SECRETARIAL ORDER 3362

WYOMING EMPLOYMENT SUPPORT PROJECT (WESP)

THE PRIMA RY MISSION OF THE WYOMING NASA SPACE GRANT CONSORTIUM (WSGC), BASED ON NASA'S STRATEGIC PLAN, LINES OF BUSINESS, AND EDUCATION PRIORITIES,

WYOMING INSTITUTE FOR DISABILITIES: WYOMING'S UNIVERSITY CENTER FOR EXCELLENCE IN DEVELOPMENTAL DISABILITIES EDUCATION,

UNIVERSITY OF WYOMING UPWARD BOUND - 2017

EDUCATIONAL OPPORTUNITY CENTERS PROGRAM

UTILIZING INTRINSICALLY DISORDERED PROTEINS AND COSOLUTES TO INDUCE REVERSIBLE BIOSTASIS IN HUMAN WHOLE BLOOD

PROTEIN EXCHANGE AND SELF RECOGNITION IN MYXOBACTERIA BIOFILMS

MANUFACTURING-WORKS (THE WYOMING MEP)AT THE UNIVERSITY OF WYOMING

THE PRIMARY MISSION OF THE WYOMING NASA SPACE GRANT CONSORTIUM (WSGC), BASED ON NASA'S EDUCATION OUTCOMES, IS: 1) TO PROMOTE A STRONG EDUCATIONAL BA

COLLABORATIVE RESEARCH: CI-WATER, CYBERINFRASTRUCTURE TO ADVANCE HIGH PERFORMANCE WATER RESOURCE MODELING

MECHANISMS OF NUCLEAR SIZE REGULATION

AWARD TYPE: PROJECT GRANT; ACTIVITIES TO BE PERFORMED: PROVIDE HIGH QUALITY SUPPORT AND TECHNICAL ASSISTANCE WITH PANDEMIC RELIEF PROGRAMS AND RECOVERY SERVICES TO SMALL BUSINESSES.; DELIVERABLES: GRANTEES WILL PROVIDE REPORTS ON ACTIVITIES AND PROGRESS TOWARD STATED GOALS TO SBA ON A QUARTERLY BASIS.; EXPECTED OUTCOMES: INCREASE AWARENESS OF AND PARTICIPATION IN PROGRAMS OF THE U.S SMALL BUSINESS ADMINISTRATION AND OTHER GOVERNMENT AGENCIES.; INTENDED BENEFICIARIES: SMALL BUSINESSES AND ENTREPRENEURS THAT FALL INTO A HISTORICALLY UNDERSERVED CATEGORY, INCLUDING MINORITY ENTREPRENEURS (BLACK, INDIGENOUS, AND PEOPLE OF COLOR), ENTREPRENEURS WITH DISABILITIES, LGBTQ ENTREPRENEURS, RURAL ENTREPRENEURS; VETERANS AND MILITARY ENTREPRENEURS (INCLUDING SPOUSES), WOMEN ENTREPRENEURS, INNOVATIVE STARTUPS, MICRO BUSINESSES, AND SOCIALLY AND ECONOMICALLY DISADVANTAGED SMALL BUSINESSES; SUBRECIPIENT ACTIVITIES: GRANTEES (HUBS) AND THEIR CONTRACTORS (SPOKES) WILL PROVIDE HIGH QUALITY SUPPORT AND TECHNICAL ASSISTANCE WITH PANDEMIC RELIEF PROGRAMS AND RECOVERY SERVICES TO SMALL BUSINESSES. THIS SUPPORT TAKES THE FORM OF 1:1 COUNSELING AND GROUP TRAININGS.

DISSEMINATION OF NANOTECHNOLOGIES FOR ENERGY PRODUCTION AND ENVIRONMENT PROTECTION IN RURAL AREAS OF WYOMING

WYOMING KING AIR AS A NATIONAL FACILITY

AMERICAN RESCUE PLAN ACT FUNDING FOR HEALTH CENTERS

IMPACT 307

EDUCATIONAL OPPORTUNITY CENTERS PROGRAM

FY 17 WY BIOLOGICAL CONTROL WYOMING WEED

UPWARD BOUND

PREVENTION TECHNOLOGY TRANSFER CENTERS FOR REGION 8 - THE WYOMING SURVEY & ANALYSIS CENTER (WYSAC) IS UNIQUELY QUALIFIED TO PROVIDE TRAINING AND TECHNICAL ASSISTANCE (T/TA) TO THE SUBSTANCE MISUSE PREVENTION COMMUNITY IN THE DEPARTMENT OF HEALTH AND HUMAN SERVICE (HHS) REGION 8 THROUGH THE ESTABLISHMENT OF A MOUNTAIN PLAINS PREVENTION TECHNOLOGY TRANSFER CENTER (REGION 8 PTTC) AT THE UNIVERSITY OF WYOMING, IN PARTNERSHIP WITH THE EDUCATIONAL DEVELOPMENT CENTER, INC. (EDC). THE TARGET POPULATION FOR THE PTTC AT THE UNIVERSITY OF WYOMING WILL INCLUDE KEY STATE AND LOCAL PREVENTION PROFESSIONALS, COALITION MEMBERS, PRE-PROFESSIONALS DESIRING TO ENTER THE FIELD, TRIBAL MEMBERS, AND OTHER INTERESTED PARTIES. WITH A TOTAL OF SIX RELATED STATE AGENCIES, 281 COUNTIES, AND 29 TRIBES, MANY WITH PREVENTION COALITIONS AND STAFF, WE ESTIMATE SERVING AT LEAST AS 2,000 UNIQUE INDIVIDUALS EACH YEAR, WITH A TARGET OF 15,000 OVER THE LIFETIME OF THE COLLABORATIVE AGREEMENT. GOALS FOR THE PTTC AT THE UNIVERSITY OF WYOMING INCLUDE THE DELIVERY OF HIGH-QUALITY T/TA TO THE SUBSTANCE MISUSE PREVENTION WORKFORCE IN REGION 8 AND ACROSS THE COUNTRY, SUPPORTING AND BUILDING THE SUBSTANCE MISUSE PREVENTION WORKFORCE IN REGION 8 AND ACROSS THE COUNTRY THROUGH COLLABORATION AND COMMUNICATION WITH STATE AGENCIES, TRIBAL NATIONS, AND THE PTTC NETWORK, AND ADVANCING THE SUBSTANCE MISUSE PREVENTION FIELD THROUGH SUBJECT MATTER EXPERTISE IN DATA COLLECTION, NEEDS ASSESSMENT, PROCESS AND OUTCOME EVALUATION, DATA VISUALIZATION, AND THE DEVELOPMENT OF A PREVENTION FELLOWSHIP PROGRAM. WYSAC FILLS A GAP IN THE CURRENT PTTC SYSTEM WITH SPECIAL EXPERTISE IN DATA COLLECTION, NEEDS ASSESSMENT, PROCESS AND OUTCOME EVALUATION, DATA VISUALIZATION, AND THE USE OF APPLIED PREVENTION RESEARCH TO IMPROVE THE QUALITY OF INTERVENTIONS, TRAININGS, AND OTHER PREVENTION SERVICES.

LOSS OF TDP-43 DISRUPTS THE PREFRONTAL NEURAL ACTIVITY AND CIRCUITRY: RELEVANCE FOR TDP-43 LINKED ADRD - THE OVERARCHING GOAL OF THIS PROPOSAL IS TO DETERMINE THE PATHOGENIC MECHANISM BY WHICH LOSS OF TAR DNA-BINDING PROTEIN 43 KDA (TDP-43) CONTRIBUTES TO THE EARLIEST NEURAL ACTIVITY AND NETWORK CHANGES THAT PRECEDE NEURON LOSS IN DISORDERS ASSOCIATED WITH TDP-43 PATHOLOGY. ALZHEIMER'S DISEASE (AD) AND ALZHEIMER'S DISEASE RELATED DEMENTIAS (ADRD) ARE THE MOST COMMON FORMS OF DEMENTIA CURRENTLY WITHOUT DISEASE MODIFYING THERAPY. ADRD SHARES MANY COGNITIVE AND PATHOLOGICAL FEATURES WITH AD AND CAN BE CLINICALLY DIFFICULT TO DISTINGUISH FROM AD. ONE OF THE MOST COMMON NON-CANONICAL PATHOLOGIC HALLMARKS OF AD IS TDP-43 PROTEINOPATHY, WHICH OCCURS IN ~30-57% OF AD BRAINS (AD-TDP). TDP-43 PROTEINOPATHY, FIRST SHOWN TO BE A MAJOR PATHOLOGICAL HALLMARK OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) AND IN A MAJOR SUBTYPE OF FRONTOTEMPORAL LOBAR DEGENERATION (FTLD-TDP), IS ALSO FOUND IN OTHER NEURODEGENERATIVE DISEASES. SINCE COGNITIVE DECLINE AND BRAIN ATROPHY ARE EXACERBATED IN AD TDP RELATIVE TO AD, UNDERSTANDING THE PATHOGENIC ROLE OF TDP-43 IN AD-TDP AND FTLD-TDP THAT CONTRIBUTES TO THE EARLIEST NEURAL CIRCUIT ABNORMALITIES COULD FACILITATE IDENTIFICATION OF NOVEL THERAPEUTIC TARGETS AND TREATMENT STRATEGIES. BASED ON OUR PRELIMINARY STUDIES, WE HYPOTHESIZE THAT TDP-43 PLAYS ESSENTIAL ROLES IN MAINTAINING NORMAL NEURAL ACTIVITY AND CIRCUITRY THROUGH REGULATING RNA SPLICING OF SPECIFIC CALCIUM CHANNELS. TO TEST THIS HYPOTHESIS, WE WILL TAKE A MULTIDISCIPLINARY APPROACH CAPITALIZING ON OUR TEAM’S EXPERTISE IN TDP-43 BIOLOGY, MOUSE GENETIC AND NEUROPATHOLOGY, IN VIVO CALCIUM IMAGING AND CIRCUIT ANALYSIS IN MOUSE MODELS, AND TDP-43 DEPLETED CORTICAL NEURONS DERIVED FROM HPSC AND PATIENT-SPECIFIC IPSC MODELS. WE HAVE THE FOLLOWING THREE SPECIFIC AIMS. IN AIM #1, WE WILL PERFORM REPETITIVE IN VIVO CALCIUM IMAGING TO MONITOR CALCIUM ACTIVITY CHANGES FROM THE SAME PYRAMIDAL NEURONS IN AWAKE BEHAVING MICE, TO DETERMINE THE IMPACT OF PYRAMIDAL TDP-43 LOSS TO THE CORTICAL NETWORK. IN AIM #2, WE WILL PERFORM REPETITIVE IN VIVO CALCIUM IMAGING TO DETERMINE THE CONSEQUENCE OF TDP-43 DEPLETION SPECIFICALLY IN INHIBITORY INTERNEURONS OR SPARSELY IN BOTH EXCITATORY AND INHIBITORY NEURONS OF THE PFC. IN AIM #3, WE WILL USE MOUSE MODELS, HPSC DERIVED CORTICAL NEURONS, AND PATIENT BRAIN TISSUES OF AD-TDP AND FTLD-TDP TO DETERMINE THE MOLECULAR MECHANISMS WHEREBY TDP-43 LOSS LEADS TO EARLY ABERRANT NEURAL ACTIVITY IN THE PFC. WE BELIEVE THAT OUR WORK WILL NOT ONLY CLARIFY EARLY PATHOGENIC MECHANISMS OF TDP-43 LOSS BUT ALSO IDENTIFY NOVEL THERAPEUTIC TARGETS AND DESIGN OF EFFECTIVE THERAPEUTIC STRATEGY TO ATTENUATE THESE DEVASTATING DISORDERS OF THE ELDERLY

UNIVERSITY OF WYOMING STUDENT SUPPORT SERVICES PROJECT: 2020-2025

GERIATRIC EDUCATION CENTERS

UNIVERSITY CENTER FOR EXCELLENCE IN DEVELOPMENTAL DISABILITIES EDUCATION RESEARCH AND SERVICE

SELF-NONSELF RECOGNITION AND MULTICELLULARITY IN MYXOBACTERIA - ABSTRACT A FUNDAMENTAL QUESTION IN BIOLOGY IS HOW INDIVIDUAL CELLS WITHIN A MULTICELLULAR ORGANISM RECOGNIZE OTHER CELLS AS SELF TO COOPERATIVELY FUNCTION IN TISSUES, ORGANS AND AS WHOLE INDIVIDUALS. TO ADDRESS THIS COMPLEX QUESTION, WE STUDY A RELATIVELY SIMPLE AND EXPERIMENTALLY TRACKABLE MODEL ORGANISM, MYXOCOCCUS XANTHUS. ALTHOUGH A BACTERIUM, M. XANTHUS EXHIBITS MANY TRAITS FOUND IN TISSUES AND MORE COMPLEX MULTICELLULAR SPECIES. ONE TRAIT IS MULTICELLULAR DEVELOPMENT IN RESPONSE TO STARVATION. ANOTHER TRAIT, WE DISCOVERED, IS THE ABILITY OF CELLS TO DISTINGUISH BETWEEN SELF AND NONSELF FOR THE EXCHANGE OF CELLULAR PROTEINS AND LIPIDS. RECOGNITION IS MEDIATED BY A POLYMORPHIC CELL SURFACE RECEPTOR CALLED TRAA AND ITS PARTNER TRAB. ONLY CELLS THAT BEAR IDENTICAL OR NEARLY IDENTICAL TRAA RECEPTORS ENGAGE BY HOMOTYPIC INTERACTIONS. SOCIAL OUTCOMES FROM THIS PROCESS, CALLED OUTER MEMBRANE EXCHANGE (OME), VARY DEPENDING ON THE PROPERTIES OF THE INTERACTING CELLS. IN SOME CASES, OME LEADS TO COOPERATIVE INTERACTIONS WHEREBY HEALTHY DONORS REPAIR DAMAGED CELLS BY REPLENISHING THEIR CELL COMPONENTS. IN OTHER CASES, OME LEADS TO ANTAGONISM WHEN PARTNERING CELLS ARE NOT CLONAL. DISCRIMINATION OCCURS BY POLYMORPHIC TOXIN TRANSFER TO RECIPIENT CELLS THAT LACK COGNATE IMMUNITY. OUR FUTURE GOALS ARE MULTIFACETED WITH RESPECT TO UNDERSTANDING OME AND, MORE BROADLY, HOW CELLS RECOGNIZE SELF AND TRANSITION TOWARD MULTICELLULARITY. OVER THE NEXT FIVE YEARS WE WILL CRITICALLY EXAMINE HOW OME LEADS TO COOPERATIVITY. ONE AREA OF INVESTIGATION IS HOW TRAA/B DIRECTS EMERGENT BEHAVIORS IN POPULATIONS THAT INCLUDE SYNCHRONIZED AND COORDINATED MOVEMENTS. THIS WILL BE EXPLORED BY MONITORING GLOBAL GENE EXPRESSION AND HOW TRAA/B INTERACTS WITH A SIGNAL TRANSDUCTION PATHWAY THAT CONTROLS MOTILITY. CELL SYNCHRONIZATION IS BEING STUDIED WITH A BIOSENSOR THE MONITORS’ CALCIUM FLUXES IN CELLS. OTHER APPROACHES WILL PROBE HOW M. XANTHUS RESPONDS AND ADAPTS TO ENVIRONMENTAL STRESSES, WHEREBY THOSE ADAPTATIONS ARE TRANSFERRED TO NAÏVE POPULATIONS BY OME. A SECOND AREA OF RESEARCH ADDRESSES HOW MYXOBACTERIA RAPIDLY DIVERGE INTO DIFFERENT SOCIAL GROUPS IN NATURAL ENVIRONMENTS. OUR PRELIMINARY FINDINGS INDICATE THAT HORIZONTAL GENE TRANSFER BY NON-LYTIC TRANSDUCING PARTICLES MEDIATE POPULATION DIVERGENCE BY CARRYING POLYMORPHIC GENES INVOLVED IN SOCIAL DISCRIMINATION. A THIRD FOCUS AREA WILL ELUCIDATE THE MECHANISM OF OME THOUGHT TO INVOLVE OUTER MEMBRANE FUSION. FINALLY, WE WILL EXPLORE NEW MECHANISMS OF SELF- RECOGNITION AND ITS ROLE IN MULTICELLULAR LIFE.

NEW AWARD TO THE UNIVERSITY OF WYOMING, AWARD NUMBER: DE-FE0032048, PROJECT ENTITLED: POWDER RIVER BASIN CORE-CM: ADVANCING STRATEGIES FOR CARBON ORE, RARE EARTH ELEMENT, AND CRITICAL MINERAL RESOURCE DEVELOPMENT IN THE NATION'S LARGEST COAL PRODUCING BASIN.

NEW AWARD TO THE UNIVERSITY OF WYOMING, AWARD NUMBER: DE-FE0032047. PROJECT ENTITLED: CORE-CM IN THE GREATER GREEN RIVER AND WIND RIVER BASINS: TRANSFORMING AND ADVANCING A NATIONAL COAL ASSET.

HEALTH CENTER PROGRAM