Ferris State University

FERRIS STATE UNIVERSITY - CARES ACT 2020 - INSTITUTION

FERRIS STATE UNIVERSITY - USDOE CARES ACT RELIEF FUND 2020

FERRIS STATE UNIVERSITY HEERF CARES ACT SIP FUNDING

CCAMPIS 2022 FERRIS STATE UNIVERSITY

PURPOSE: THE PURPOSE OF THIS GRANT IS TO SUPPORT THE PURCHASE AND INTEGRATION OF EQUIPMENT CRITICAL TO DESIGNING AND TESTING NOVEL CHEMICAL COMPOUNDS THAT TARGET DRUG-RESISTANT CANCERS AND ADVANCE SCIENTIFIC UNDERSTANDING OF CHEMICAL DRUG RESISTANCE, AT FERRIS STATE UNIVERSITY. ACTIVITIES TO BE PERFORMED: KEY ACTIVITIES INCLUDE, FIRST, THE PURCHASE AND INSTALLATION OF THE FOLLOWING EQUIPMENT AT THE UNIVERSITY: 500 MHZ NMR SPECTROMETER, 125 - 200 KVA GENERATOR(S), BENCHTOP LCMS, FLOW CYTOMETER, BENCHTOP NMR, PARTICLE SIZE ANALYZER, CHEMICAL FUME HOOD(S), GAS CHROMATOGRAPH. THE SECOND KEY ACTIVITY OF THE PROJECT IS THE HIRING OF A LAB TECHNICIAN TO, AMONG OTHERS, HELP DEVELOP AND ESTABLISH TRAINING PROTOCOLS ON THE EQUIPMENT. EXPECTED OUTCOMES: PURCHASE AND INSTALLATION OF THE EQUIPMENT, THE HIRING OF A TECHNICIAN, AND USER INSTRUMENT TRAINING ARE ALL CRITICAL TO IMPROVING THE ORGANIZATION?S CAPACITY TO MEASURE, ANALYZE, SYNTHESIZE, PROCESS, AND FABRICATE NOVEL CHEMICAL COMPOUNDS THAT TARGET DRUG-RESISTANT CANCERS AND TO ADVANCING THE SCIENTIFIC UNDERSTANDING OF CHEMICAL DRUG RESISTANCE, INCLUDING PROCESSES OF DEGRADATION THAT IMPACT DRUG STABILITY. THIS FUNDING WILL FACILITATE THE UNIVERSITY'S LONG-TERM GOALS OF BUILDING ON ITS CURRENT STRENGTHS IN CANCER RESEARCH, EASING A BIOMEDICAL WORKFORCE GAP WITH ENHANCED PREPARATION OF STUDENTS TOWARD STEM AND RESEARCH-RELATED CAREERS, AND BRINGING PARITY OF OPPORTUNITY FOR RESEARCH INNOVATIONS TO A RURAL INSTITUTION. INTENDED BENEFICIARIES: THE MAIN BENEFICIARY WILL BE THE LOCAL COMMUNITY, AS 92 % OF FERRIS UNIVERSITY STUDENTS COME FROM MICHIGAN AND THE VAST MAJORITY OF GRADUATES REMAIN IN-STATE. FURTHERMORE, SEVERAL OF THE CHRONIC DISEASES TARGETED FOR STUDY (E.G., CANCER, DIABETES, HEART DISEASE) DISPROPORTIONATELY AFFECT RURAL AND UNDERREPRESENTED CITIZENS, BOTH IN MICHIGAN AND BEYOND. AS SUCH, SCIENTIFIC DEVELOPMENTS RESULTANT FROM THIS FUNDING SHOULD IMPACT BEYOND THE UNIVERSITY AND STATE. SUBRECIPIENT ACTIVITIES: THE RECIPIENT DOES NOT INTEND TO SUBAWARD FUNDS.

RURAL HEALTH NETWORK DEVELOPMENT PROGRAM - APPLICANT ORGANIZATION INFORMATION: FERRIS STATE UNIVERSITY, 1201 S STATE ST., BIG RAPIDS, MI 49307-2747 FACILITY/ENTITY TYPE: NONPROFIT 501(C)(3) INSTITUTE OF HIGHER EDUCATION WEBSITE: WWW.FERRIS.EDU PROJECT DIRECTOR GAIL L. BULLARD, DHED RN, PHONE NUMBER 517-281-2225, EMAIL GAILBULLARD@FERRIS.EDU KEY STAFF: PRINCIPAL INVESTIGATOR SCOTT SEXTON, PHARMD, PHONE NUMBER 231-591-2240, EMAIL SCOTTSEXTON@FERRIS.EDU; GRANTS ADMINISTRATOR WENDY STAPP, PHONE NUMBER 231-591-2547, EMAIL WENDYSTAPP@FERRIS.EDU; INTERIM NETWORK DIRECTOR JESSICA A. WIMMER, BA, PHONE NUMBER 231-519-1115, EMAIL JESI.WIMMER@GMAIL.COM; RURAL HEALTH NETWORK DEVELOPMENT PROJECT: PROJECT TITLE: RURAL SUBSTANCE USE DISORDER NETWORK: FERRIS STATE UNIVERSITY (CMREN-FSU). GOAL: NETWORK DEVELOPMENT OF A SOBER RECOVERY ECOSYSTEM TO 1) DECREASE THE INCIDENCE OF OVERDOSE-RELATED MORBIDITY AND MORTALITY 2) INCREASE THE INCIDENCE OF LONG-TERM RECOVERY AND 3) DECREASE THE INCIDENCE OF OVERDOSE AND SUBSTANCE USE DISORDER (SUD) THROUGH IMPROVED INTEGRATED CARE FOR PERSONS WITH SUD, WITH A SPECIAL FOCUS ON THOSE WITH SUD IN FOUR SUBPOPULATIONS: VETERANS, PREGNANT WOMEN, THOSE RELEASED FROM INCARCERATION, AND HOMELESS ADOLESCENTS AND ADULTS. FOCUS AREA(S): SUBSTANCE USE DISORDER TARGET PATIENT POPULATION: INDIVIDUALS WITH SUD IN THE MICHIGAN FOUR-COUNTY AREA OF MECOSTA, MONTCALM, NEWAYGO, AND OSCEOLA WITH SUBPOPULATION FOCUS AS DESCRIBED IN THE PROJECT GOAL. THE PERSONS RESIDE IN HRSA DESIGNATED RURAL COUNTIES WITH HEALTH PROFESSIONAL SHORTAGE AREAS FOR PRIMARY CARE, MENTAL HEALTH, AND DENTAL CARE. NETWORK MEMBERS: NETWORK NAME CENTRAL MICHIGAN RECOVERY AND EDUCATION NETWORK: FERRIS STATE UNIVERSITY TOTAL NUMBER OF MEMBER ORGANIZATIONS: 13 FACILITY/ENTITY TYPE OF ORGANIZATIONS: 7 TYPES: HIGHER EDUCATION, PUBLIC HEALTH, BEHAVIORAL HEALTH, HEALTH CARE, SUD PREVENTION, RECOVERY SUPPORT, AND HUMANITARIAN. NETWORK PROJECT ACTIVITIES/SERVICES: JOINTLY THE NETWORK WILL IDENTIFY GAPS AND AMPLI FY SERVICES TO DEVELOP SEAMLESS INTEGRATED CARE FOR THOSE SEEKING SUSTAINABLE SUD RECOVERY. EXPECTED OUTCOMES: IMPROVE ACCESS: COOPERATIVELY REDUCE GAPS IN CARE, WORKFORCE SHORTAGES, WORKFLOW PROCESSES, AND QUALITY OF HEALTH CARE SERVICES FOR PERSONS WITH SUD TO IMPROVE ACCESS TO QUALITY, AFFORDABLE CARE. EXPAND CAPACITY AND SERVICES: JOINTLY DEVELOP EFFECTIVE KNOWLEDGE, SKILLS, STRUCTURES, AND LEADERSHIP MODELS FOR EXPANDED CAPACITY USING INTEGRATED CARE FOR SUD SERVICES INCLUDING USE OF UNIVERSITY CLINICS THAT TRAIN THE FUTURE WORKFORCE. ENHANCE OUTCOMES: DEVELOP A SOBER RECOVERY ECOSYSTEM TO INCREASE INCIDENCE OF LONG-TERM RECOVERY, AND LOWER OVERDOSE DEATHS THROUGH A TEAM APPROACH TO IMPROVE PATIENT AND NETWORK OUTCOMES WHICH AMPLIFY COMMUNITY SUD SERVICES, ACTIVITIES, AND INTERVENTIONS. SUSTAINABILITY: JOINTLY CREATE A SUSTAINABLE BUSINESS MODEL OF SUD-FOCUSED HEALTH PROGRAMS BY DEVELOPING A SOBER RECOVERY ECOSYSTEM THROUGH VALUE-BASED, INTEGRATED CARE AND POPULATION HEALTH MANAGEMENT. CAPACITY TO SERVE RURAL UNDERSERVED POPULATIONS: FERRIS STATE UNIVERSITY COMPLETED INITIAL PLANNING THROUGH A HRSA RURAL COMMUNITIES OPIOID RESPONSE PLANNING GRANT, RCORP PLANNING II (GRANT #G25RH32943), ESTABLISHING A COALITION TO ADDRESS SUD THROUGH HRSA RCORP-IMPLEMENTATION GRANT (GRANT #GA1RH39558) TO IMPLEMENT SERVICES TO REDUCE THE MORBIDITY AND MORTALITY OF SUD, INCLUDING OPIOID USE DISORDER (OUD). SUCCESSES INCLUDE PHARMACY SUD TELEHEALTH, COMMUNITY SUD EDUCATION, NARCAN DISTRIBUTION, AND A NEW FAMILIES AGAINST NARCOTICS CHAPTER INCLUDING A HOPE NOT HANDCUFFS PROGRAM. THESE INITIATIVES DEMONSTRATE THE NETWORKS COLLABORATIVE ABILITY TO ADDRESS THE UNDERSERVED RURAL POPULATIONS EXPERIENCING SUD. FUNDING PREFERENCE QUALIFICATION 1: HEALTH PROFESSIONAL SHORTAGE AREA (HPSA). FERRIS STATE UNIVERSITY IS IN BIG RAPIDS, MICHIGAN, MECOSTA COUNTY. ALL NETWORK COUNTIES, MECOSTA, MONTCALM, OSCEOLA, AND NEWAYGO, HAVE HPSA DESIGNATION.

COLLABORATIVE RESEARCH: EXPLORING SUSTAINABLE STRATEGIES TO SUPPORT SUCCESS OF STEM STUDENTS WITH FINANCIAL NEED

BEHAVIORAL HEALTH WORKFORCE EDUCATION AND TRAINING PROGRAM - THE EMPOWERING NORTHERN MICHIGAN: BEHAVIORAL EDUCATION IN DIVERSE RURAL COMMUNITIES (EMN) PROJECT WILL INCREASE THE SUPPLY OF A DIVERSE BEHAVIORAL HEALTH WORKFORCE WHO ARE TRAINED TO PROVIDE INTEGRATED BEHAVIORAL HEALTH CARE AND COMMITTED TO WORK IN HIGH-NEED AND HIGH-DEMAND AREAS. THE OVERARCHING GOAL OF THE WORK PLAN IS TO ESTABLISH AN MSW FELLOWSHIP PROGRAM THAT IMPROVES THE OVERALL MENTAL HEALTH OF HIGH NEEDS AND UNDERSERVED COMMUNITIES IN NORTHERN MICHIGAN. THE PROJECT WILL ACCOMPLISH THIS BY LEVERAGING THE EXISTING SUCCESSES OF THE FERRIS MSW PROGRAM WITH ADDITIONAL RESOURCES FOCUSED ON ENHANCING, EXPANDING, AND FORMALIZING KEY ELEMENTS OF ITS PARTNERSHIPS, TRAINING MODELS, RECRUITMENT, AND CLINICAL SUPERVISORY NETWORK CAPACITY. IN ITS PARTNERSHIPS, THE PROJECT WILL SEEK TO EXPAND COMMUNITY RELATIONSHIPS WITH HIGH-IMPACT AGENCIES IN RURAL COMMUNITIES BY RESOURCING EVIDENCED-BASED ENHANCEMENTS IN DIDACTIC AND EXPERIENTIAL TRAINING ACTIVITIES THAT EMPHASIZE TEAM-BASED AND INTEGRATED CARE, AS WELL AS TECHNOLOGY INTEGRATION AND TELEHEALTH. AS AN INSTITUTION BOTH EMBEDDED AND INVESTED IN THE SUCCESS OF HIGH-NEED AND HIGH-DEMAND AREAS, WITH A PROVEN RECORD OF ATTRACTING AND TRAINING STUDENTS WHO SHARE A COMMITMENT TO THOSE AREAS BASED ON THEIR OWN ARRAY OF LIVED EXPERIENCES, FERRIS STATE IS UNIQUELY POSITIONED TO RESPOND TO THE PROGRAMMATIC PURPOSE OF THE BHWET PROGRAM. TO SUPPORT STUDENTS AND THEIR ABILITY TO SUSTAINABLY BRING THEIR TALENTS AND SKILLS TO COMMUNITIES IN NEED, THE PROJECT SEEKS TO ADDRESS FINANCIAL BARRIERS THROUGH ENM STIPENDS, ALLEVIATING BOTH BARRIERS TO PARTICIPATION IN THE PROGRAM AND TO LONG-TERM FINANCIAL HARDSHIP IN THE FORM OF DEBT ACCRUAL. THE ENM FELLOWSHIP WILL PREPARE AN EQUIVALENT OF 52 FULL-TIME ADVANCED STANDING CLINICAL SOCIAL WORK STUDENTS, 13 PER YEAR FOR FOUR YEARS, IN A TARGETED GROUP OF HIGH-IMPACT AGENCIES ACROSS UNDERSERVED RURAL COMMUNITIES THROUGHOUT THE NORTHERN HALF OF THE STATE OF MICHIGAN, RANGING FROM ISABELLA TO BENZIE COUNTY. THE PROGRAM WILL REINFORCE 1. TRAUMA INFORMED CARE FOR UNDERSERVED POPULATIONS, 2. INTERPROFESSIONAL AND TEAM-BASED TRAINING AND EXPERIENCES, AND 3. THE UNIQUE RESOURCES OF FERRIS STATE UNIVERSITY IN LOCATION, EXPERIENTIAL LEARNING, REMOTE TECHNOLOGY, AND ANTI-RACIST PEDAGOGY IN INTERNSHIP SETTINGS FOCUSED ON SCHOOL SOCIAL WORK, DOMESTIC VIOLENCE TREATMENT, LGBTQ+ SERVICES, MEDICAL SOCIAL WORK, MENTAL HEALTH, AND SUBSTANCE USE DISORDER TREATMENT. FERRIS STATE UNIVERSITY IS REQUESTING FUNDING PRIORITY UNDER PRIORITY 1 DUE TO THE ONGOING WORK AND PLANNED PARTNERSHIP IN THE ENM PROJECT BY THE UNIVERSITY'S INTERPROFESSIONAL EDUCATION (IPE) COMMITTEE, WHICH HAS TRAINED MORE THAN 150 MSW STUDENTS IN THE PAST THREE YEARS. THE UNIVERSITY IS ALSO REQUESTING FUNDING PREFERENCE UNDER QUALIFICATION 1. 74.3% OF MSW GRADUATES IN THE PAST TWO YEARS WERE PLACED IN PRACTICE SETTINGS SERVING IN MEDICALLY UNDERSERVED COMMUNITIES (MUCS), PREDOMINANTLY IN RURAL HPSAS.

THE FUNDING WILL BE USED TO SUPPORT PHASE TWO OF CONSTRUCTION OF THE FERRIS STATE UNIVERSITY CENTER FOR VIRTUAL LEARNING, SPECIFICALLY TOWARD EQUIPPING AND INSTALLING THE TECHNOLOGY AND ISOLATED NETWORK CAPACITY ESSENTIAL TO MAXIMIZE THE POTENTIAL OF THE FACILITY.

RURAL COMMUNITIES OPIOID RESPONSE-IMPLEMENTATION

FOSTERING EQUITY FOR FIRST-GENERATION AND FIRST-GENERATION LOW-INCOME STUDENT SUCCESS: A COMPREHENSIVE APPROACH TO IMPROVING EDUCATIONAL TRANSITION, PERSISTENCE, AND GRADUATION.

DISTANCE LEARNING GRANT

FERRIS STATE UNIVERSITY CCAMPIS PROGRAM: PROMOTING SUCCESS IN TWO GENERATIONS OF STUDENT LEARNERS

THE JIM CROW MUSEUM OF RACIST IMAGERY AT FERRIS STATE UNIVERSITY WILL DESIGN AND INSTALL A NEW PERMANENT EXHIBIT ON ITS BIG RAPIDS, MICHIGAN CAMPUS TO CREATE MORE ACCESSIBLE, ENGAGING, AND ROBUST EXPERIENCES FOR STUDENTS, EDUCATORS, RESEARCHERS, AND THE PUBLIC. THE MUSEUM WILL WORK WITH AN EXHIBIT CONSULTANT TO DESIGN AND FABRICATE A NEW EXHIBIT THAT WILL INCLUDE NEW STORIES FOCUSED ON JIM CROW AND CIVIL RIGHTS IN MICHIGAN AND BUILDING A MORE JUST SOCIETY. THE EXHIBIT WILL EXPAND THE MUSEUM’S CAPACITY TO SERVE A BROADER AND MORE DIVERSE AUDIENCE THROUGH EXPANDED PHYSICAL SPACE AND IN-PERSON PROGRAMMING. THE NEW EXHIBITION WILL ENABLE THE JIM CROW MUSEUM OF RACIST IMAGERY TO ENHANCE ITS ROLE AS A FORUM FOR DIFFICULT DISCUSSIONS AS GROUPS AND INDIVIDUALS SEEK TO UNDERSTAND THE HISTORY OF RACE AND RACISM IN AMERICA.

EFFECT OF UVA IRRADIATION ON MELANOCYTE STEM CELLS AND RELATIONSHIP TO DEVELOPMEN

CHILD CARE ACCESS MEANS PARENTS IN SCHOOL PROGRAM

LOAN GRANT WITH FUNDS FOR NEW BUDGET PERIOD

RUI: BIOPOLYMER - BIOBRICKS POLYKETIDE METABOLIC ENGINEERING PLATFORM

COMBINATORIAL BIOSYNTHESIS AND METABOLISM STUDIES OF NOVEL TETRACENOMYCINS

NOVEL DUAL-TARGETED INHIBITORS OF EGFR AND AURORA KINASE FOR LUNG CANCER - PROJECT SUMMARY SMALL MOLECULE EGFR INHIBITORS CONSTITUTE THE RECOMMENDED THERAPY FOR EGFR-POSITIVE NON-SMALL CELL LUNG CANCER (NSCLC). RESISTANCE WAS FIRST REPORTED TO EGFR INHIBITORS THROUGH MUTATIONS IN THE ATP POCKET THAT WAS ADDRESSED BY A NEW GENERATION OF IRREVERSIBLE EGFR INHIBITORS. HOWEVER, RESISTANCE HAS CONTINUED TO EVOLVE WITH THE MORE RECENT CONTRIBUTORS OF RESISTANCE BEING THE L858R/T790M/C797S MUTATIONS IN MEGFR+ NSCLC AND MUTANT KRAS SIGNALING THAT BYPASSES EGFR INHIBITION IN MKRAS+ NSCLC. THERE ARE CURRENTLY NO VIABLE EGFR-MEDIATED TREATMENTS FOR MKRAS+ NSCLC. OUR GOAL IS TO DEVELOP NOVEL MOLECULES THAT PROVIDE MORE EFFECTIVE OPTIONS TO TREAT MKRAS+ AND MEGFR+ NSCLC. AURORA KINASES (AURK) ARE MITOTIC KINASES INVOLVED IN CENTROSOME MATURATION AND SEPARATION DURING MITOSIS. IN ADDITION, AURORA KINASES DRIVE TUMORIGENESIS AND METASTASIS. AURORA KINASE INHIBITORS HAVE DEMONSTRATED IMPROVED ANTICANCER EFFECTS WHEN USED IN COMBINATION WITH EGFR INHIBITORS IN BOTH MKRAS+ AND MEGFR+ NSCLC. THUS, DUAL EGFR/AURK INHIBITION PROVIDES A UNIQUE APPROACH TO OVERCOME RESISTANCE TO EGFR INHIBITORS. WE HAVE IDENTIFIED NOVEL MOLECULES WITH DUAL EGFR/AURK INHIBITION IN OUR LAB. OUR COMPOUNDS DEMONSTRATED NANOMOLAR TO MICROMOLAR POTENCIES AGAINST EGFR AND AURK. ADDITIONALLY, OUR COMPOUNDS DEMONSTRATED PREFERENTIAL INHIBITION OF EGFR AND AURK IN A 96- KINASE SELECTIVITY PANEL. THE GOAL OF THIS PROPOSAL IS TO OPTIMIZE LEAD MOLECULES IDENTIFIED IN OUR LAB FOR POTENT DUAL EGFR AND AURK INHIBITION THAT WOULD TRANSLATE TO ENHANCED ANTIPROLIFERATIVE EFFECTS IN MKRAS+ AND MEGFR+ NSCLC. IN AIM 1, WE WILL SYNTHESIZE NOVEL SERIES OF COMPOUNDS AS ANALOGS OF OUR LEAD COMPOUNDS. WE WILL EVALUATE THE COMPOUNDS IN ENZYMATIC ASSAYS AGAINST EGFR, MUTANT EGFR AND AURORA KINASES. SOLUBILITY WILL ALSO BE ASSESSED. IN AIM 2, WE WILL EVALUATE POTENT DUAL EGFR/AURK INHIBITORS IDENTIFIED FROM AIM 1 FOR ANTICANCER EFFECTS IN MKRAS+ AND MEGFR+ NSCLC AND TOXIC EFFECTS IN NORMAL LUNG CELLS. IN AIM 3, WE WILL INVESTIGATE SELECTIVITY FOR DUAL EGFR/AURK INHIBITION VERSUS OFF-TARGET KINASES AND METABOLIC STABILITY FOR POTENT DUAL EGFR/AURK INHIBITORS IDENTIFIED FROM AIM 2.

READY FOR LIFE AT FERRIS STATE UNIVERSITY

RUI: BIOPOLYMER - BIOBRICKS POLYKETIDE METABOLIC ENGINEERING PLATFORM FOR UNRAVELING THE BIOSYNTHESIS OF HIGHER ANTHRACYCLINES -SOIL BACTERIA PRODUCE A VARIETY OF COMPOUNDS. SOME HAVE MEDICINAL VALUE. A NOTABLE CLASS OF THESE MOLECULES ARE REFERRED TO AS ANTHRACYCLINES (ACS). ANTHRACYCLINES TREAT SEVERAL TYPES OF CANCER. THE OBJECTIVE OF THIS PROJECT IS TO UNDERSTAND THE REGULATION OF AC PRODUCTION. RELATED ENZYMES AND PATHWAYS WILL BE MIXED AND MATCHED TO PRODUCE NOVEL ACS WITH POTENTIALLY NOVEL ANTI-TUMOR PROPERTIES. THE PROJECT WILL BE PERFORMED BY UNDERGRADUATES, DIRECTED BY THE PRINCIPAL INVESTIGATOR. IT IS EXPECTED THAT INVOLVING UNDERGRADUATES IN RESEARCH WILL BE EFFECTIVE IN TRAINING THEM FOR CAREERS IN THE BIOMANUFACTURING ECONOMY. RESULTS WILL BE COMMUNICATED WITH THE PUBLIC THROUGH PODCASTS. THE OVERALL OBJECTIVE IS TO CHARACTERIZE THE BIOSYNTHESIS OF GLYCOSYLATED ACS. THESE ARE POLYKETIDE NATURAL PRODUCTS WITH ELABORATE SACCHARIDE CHAINS ADORNED WITH ONE OR MORE AMINO-SUGAR AND NITRO-SUGAR MOIETIES. NITRO-SUGARS ARE RARELY OBSERVED ON POLYKETIDES. THE ENZYMES RESPONSIBLE FOR THEIR BIOGENESIS AND ATTACHMENT ARE POORLY UNDERSTOOD. PATHWAYS WILL BE BROUGHT TOGETHER TO YIELD NEW ACS. THE CENTRAL HYPOTHESIS IS THAT THE HIGHER ANTHRACYCLINE PATHWAYS HAVE SHARED EVOLUTION AND ENZYMATIC ORIGINS. THIS WILL BE EXAMINED VIA COMPARATIVE BIOINFORMATICS TO INFORM PATHWAY CONSTRUCTION. THIS HYPOTHESIS WILL BE FUNCTIONALLY TESTED IN TWO OBJECTIVES: (1) TWO HIGHER ANTHRACYCLINE PATHWAYS WILL BE FULLY REFACTORED IN ACTINOMYCETES; AND (2) THE PROFESSOR AND HIS STUDENTS WILL USE COMBINATORIAL BIOSYNTHESIS TO SYNTHESIZE NEW AC ANALOGS EXPECTED TO HAVE ANTICANCER AND ANTIBACTERIAL ACTIVITIES. THE ULTIMATE GOAL IS TO DEVELOP DESIGN CAPABILITIES FOR SYNTHESIZING ?NEW TO NATURE? PHARMACEUTICALS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

TC: SMALL: RUI: DIGITAL LASER MICROSCOPY ANALYSIS OF ACTIVE, ALTERED, AND DAMAGED STORAGE MEDIA FOR SECURITY AND DIGITAL FORENSIC RECOVERY

BUILDING A SUSTAINABLE TRANSPORTATION SERVICE TECHNICIAN EDUCATION PROGRAM -A MAJOR SHIFT IN THE AUTOMOTIVE INDUSTRY TO ELECTRIC VEHICLES (EV) HAS CREATED A NEED FOR SKILLED TECHNICIANS BOTH REGIONALLY AND NATIONALLY. THIS PROJECT FROM FERRIS STATE UNIVERSITY WILL ESTABLISH AN INDUSTRY ALIGNED ASSOCIATE DEGREE AND CERTIFICATE PROGRAM THAT IS DESIGNED TO MEET INDUSTRY NEEDS AND SAE INTERNATIONAL EV CERTIFICATION STANDARDS TO PREPARE STUDENTS FOR EV EMPLOYMENT. OVER THE COURSE OF THE THREE-YEAR PROJECT, A NEW DEGREE AND CERTIFICATE PROGRAM WILL BE CREATED AND LAUNCHED ENABLING STUDENTS TO OBTAIN A WORKFORCE CREDENTIAL THAT WILL PREPARE THEM FOR SUCCESS IN THE RAPIDLY GROWING EV WORKFORCE. THE PROJECT WILL USE A BUSINESS AND INDUSTRY LEADERSHIP TEAM (BILT) TO MAINTAIN THE INDUSTRY-DRIVEN FOCUS OF THE DEGREE AND CERTIFICATE. THE NEW CERTIFICATE WILL ENABLE TECHNICIANS WORKING ON CONVENTIONAL AUTOMOTIVE TECHNOLOGY IN THE FIELD TO RETURN FOR A TWO-SEMESTER PROGRAM THAT WILL RE-SKILL THEM TO SUPPORT ELECTRIC VEHICLES. INSTRUCTORS FROM FERRIS STATE AND OTHER SCHOOLS IN THE AREA WILL BENEFIT FROM PROFESSIONAL DEVELOPMENT AND CERTIFICATION OPPORTUNITIES IN EV SERVICE TECHNOLOGY. STUDENTS WITHOUT PREVIOUS AUTOMOTIVE EXPERIENCE WILL BE ABLE TO EARN STACKABLE CREDENTIALS AND BE PREPARED FOR AN INTERNATIONAL CERTIFICATION IN TWO SEMESTERS AND MAY CONTINUE TO PURSUE A FOUR-SEMESTER PROGRAM FOR A TRANSFERABLE DEGREE. THE MAIN GOALS OF THE PROJECT ARE TO FOCUS ON PROGRAM AND CURRICULUM DEVELOPMENT AND IMPROVEMENTS AND ALIGN WITH THE INDUSTRY VERIFIED SKILLS NEEDED FOR THE FUTURE EV TECHNICIAN WORKFORCE. THIS PROGRAM ALSO PROVIDES A PATHWAY FOR CURRENT TECHNICIANS IN AUTOMOTIVE SERVICE TO UPDATE THEIR SKILL SET TO MEET THE GROWING NEEDS OF THEIR EMPLOYERS. COLLABORATION WITH THE BILT AND OTHER INSTITUTIONS WILL EXTEND THE REACH OF THIS PROJECT FARTHER INTO THE REGION SURROUNDING FERRIS STATE AND POTENTIALLY INCREASE ECONOMIC OPPORTUNITIES FOR THE SERVICE AREA. THE PROJECT WILL INCREASE THE NUMBER OF WORKFORCE-READY EV TECHNICIANS, THROUGH RETRAINING OF EXISTING TECHNICIANS IN EV AND EDUCATING STUDENTS WHO HAVE NOT BEEN IN THE FIELD IN SUSTAINABLE TRANSPORTATION TECHNOLOGY. FERRIS HAS A SIGNIFICANT NUMBER OF STUDENTS FROM UNDERREPRESENTED AND UNDERSERVED GROUPS AS WELL AS A LARGE NUMBER OF STUDENTS WHO ARE THE FIRST IN THEIR FAMILY TO ATTEND COLLEGE. STRATEGIC PARTNERSHIPS WILL SUPPORT THE RECRUITMENT AND RETENTION OF UNDERSERVED AND UNDERREPRESENTED STUDENTS TO SUPPORT A WELCOMING ENTRY TO HIGHER EDUCATION AND THE WORKFORCE. THIS PROJECT IS FUNDED BY THE ADVANCED TECHNOLOGICAL EDUCATION PROGRAM THAT FOCUSES ON THE EDUCATION OF TECHNICIANS FOR THE ADVANCED-TECHNOLOGY FIELDS THAT DRIVE THE NATION'S ECONOMY. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

RUI: CHEMOENZYMATIC FLUORINATION OF AROMATIC COMPOUNDS -WITH THE SUPPORT OF THE CHEMISTRY OF LIFE PROCESSES (CLP) PROGRAM IN THE DIVISION OF CHEMISTRY, S. ERIC NYBO OF FERRIS STATE UNIVERSITY IS STUDYING THE DEVELOPMENT OF ENZYMATIC TOOLS FOR INCORPORATING FLUORINE ATOMS INTO NATURAL PRODUCTS. FLUORINE IS ABUNDANT IN THE EARTH?S CRUST AND EXHIBITS IMPORTANT CHEMICAL PROPERTIES FOR PHARMACEUTICALS AND AGRICULTURAL CHEMICALS. HOWEVER, FEW EXAMPLES OF FLUORINATED NATURAL PRODUCTS EXIST, AND NATURE?S STRATEGIES FOR SYNTHESIZING COMPLEX NATURAL PRODUCTS FROM SIMPLE FLUORIDE IONS ARE NOT FULLY UNDERSTOOD. THE PROPOSED RESEARCH WILL INVOLVE UNDERGRADUATES IN STUDYING THE BIOSYNTHESIS OF ORGANOFLUORINE MOLECULES BY CLONING ENZYMES FROM BACTERIAL PATHWAYS. THE STUDENTS WILL BE TRAINED IN NMR SPECTROSCOPY USING A LOW-FIELD BENCHTOP NMR AND GENERATE NEW NATURAL PRODUCTS WITH CARBON-FLUORINE BONDS. THE STUDENTS WILL CREATE EXPLAINER VIDEOS ON SOCIAL MEDIA INTRODUCING NMR SPECTROSCOPY. THE PROJECT WILL ALSO FEATURE A COLLABORATION WITH UNDERGRADUATES FROM NEARBY DELTA COLLEGE. THE FOCUS OF THIS RESEARCH PROJECT IS THE DEVELOPMENT OF NEW CHEMOENZYMATIC STRATEGIES FOR INCORPORATING CARBON-FLUORINE BONDS INTO AROMATIC POLYKETIDES. A GOAL OF THE PROPOSED WORK IS TO CLARIFY NATURE?S ENZYMATIC STRATEGIES FOR CONVERTING INORGANIC FLUORIDE IONS TO FLUOROACETATE BY HETEROLOGOUSLY EXPRESSING THE FLUORINASE OPERON IN ESCHERICHIA COLI. THE PROJECT WILL INVOLVE INVESTIGATION OF ACYL-COA (COENZYME A) LIGASE ENZYMES FOR ACTIVATING ORGANOFLUORINE BUILDING BLOCKS TO THE CORRESPONDING FLUOROACYL THIOESTERS. DR. NYBO AND HIS STUDENTS AT FERRIS STATE UNIVERSITY WILL ALSO INVESTIGATE TYPE II AND TYPE III POLYKETIDE SYNTHASE ENZYMES CAPABLE OF LOADING FLUOROACYLATED INTERMEDIATES AND SYNTHESIZING ?NEW TO NATURE? POLYKETIDES. NEW FLUOROMETABOLITES WILL BE CHARACTERIZED VIA 19F-NMR USING A BENCHTOP NMR. THESE STUDIES HAVE THE POTENTIAL TO PROVIDE NEW INSIGHTS INTO THE GENERATION OF FLUORINATED AROMATIC MOLECULES USING ENZYMES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

CHILDCARE ACCESS MEANS PARENTS IN SCHOOL - CHILD CARE

CAMPUS VIOLENCE PREVENTION PROJECT

FERRIS STATE UNIVERSITY'S JIM CROW MUSEUM WILL CREATE CURRICULUM TO HELP SCHOOLS, MUSEUMS, LIBRARIES, AND OTHER EDUCATIONAL ORGANIZATIONS TEACH TOLERANCE AND PROMOTE SOCIAL JUSTICE THROUGH THE LENS OF THE AFRICAN AMERICAN EXPERIENCE IN THE UNITED STATES SINCE RECONSTRUCTION. THE MUSEUM WILL BRING TOGETHER EDUCATIONAL AND COMMUNITY LEADERS FROM ACROSS THE STATE OF MICHIGAN TO ASSIST WITH THE DEVELOPMENT OF A CURRICULUM FOR MIDDLE AND HIGH SCHOOL STUDENTS. THEY WILL DRAW ON PRIMARY SOURCES FROM THE JIM CROW AND CIVIL RIGHTS ERAS. THE PROJECT TEAM WILL USE THE CURRICULUM TO CREATE LESSON PLANS AND EDUCATIONAL EXPERIENCES FOR CLASSES VISITING THE MUSEUM. THE PROJECT WILL ALSO INCLUDE PROFESSIONAL DEVELOPMENT SESSIONS FOR SCHOOL ADMINISTRATORS, TEACHERS, MUSEUM PROFESSIONALS, AND OTHER EDUCATORS TO LEARN HOW TO EFFECTIVELY INCORPORATE THE CURRICULUM AND LESSON PLANS.

RUI: INNOVATIVE SIMULATIONS TO STUDY PRESSURE EFFECTS ON FUNDAMENTAL GAS-PHASE CHEMICAL PROCESSES -WITH SUPPORT FROM THE CHEMICAL STRUCTURE, DYNAMICS, AND MECHANISMS-A (CSDM-A) PROGRAM IN THE DIVISION OF CHEMISTRY, PROFESSOR LUIS RIVERA OF FERRIS STATE UNIVERSITY IS DEVELOPING COMPUTATIONAL APPROACHES TO STUDY PRESSURE EFFECTS ON GAS-PHASE FUNDAMENTAL CHEMICAL DYNAMICS PROCESSES. COMPETING CHEMICAL DYNAMICS PROCESSES SUCH AS ENERGY TRANSFER, ISOMERIZATION, AND DISSOCIATION ARE NOT WELL UNDERSTOOD IN THE HIGH-PRESSURE COLLISIONAL REGIME. CURRENT COMPUTATIONAL METHODS HAVE LIMITATIONS IN TERMS OF ACCURACY AND COMPUTATIONAL COST FOR STUDYING VIBRATIONAL ENERGY RELAXATION AND REACTION DYNAMICS IN THE HIGH-PRESSURE COLLISIONAL REGIME. PROFESSOR RIVERA AND HIS STUDENTS WILL APPLY CANONICAL APPROACHES TO DEVELOP MOLECULAR DYNAMICS SIMULATIONS THAT ARE HIGHLY ACCURATE, COMPUTATIONALLY INEXPENSIVE, AND, MORE IMPORTANTLY, WITH BROADER APPLICABILITY TO CONDENSED PHASE DYNAMICS. THEIR STUDIES COULD LEAD TO A BETTER UNDERSTANDING OF FUNDAMENTAL CHEMICAL DYNAMICS PROCESSES UNDER EXTREME CONDITIONS OF HIGH PRESSURE AND TEMPERATURE, WHICH IS OTHERWISE A CHALLENGE TO ACHIEVE BY CURRENT THEORETICAL AND EXPERIMENTAL METHODS. THE INTENDED OUTREACH ACTIVITIES WITH MIDDLE SCHOOL STUDENTS WILL PREPARE AND INSPIRE THE NEXT GENERATION OF YOUNG SCHOLARS AND SCIENTISTS. UNDERSTANDING THE MECHANISMS OF VIBRATIONAL ENERGY TRANSFER WITHIN AND AMONG MOLECULES IS FUNDAMENTAL TO UNDERSTANDING MANY PHYSICAL AND CHEMICAL PROCESSES. THE GOAL OF THIS RUI PROJECT IS TO UNDERSTAND GAS-PHASE FUNDAMENTAL CHEMICAL DYNAMICS PROCESSES, SUCH AS ENERGY TRANSFER, ISOMERIZATION, AND DISSOCIATION IN THE HIGH-PRESSURE COLLISIONAL REGIME. THIS PROJECT WILL ALSO ADDRESS THE NEED FOR EFFICIENT APPROACHES FOR GENERATING ACCURATE POTENTIAL ENERGY SURFACES (PESS) BY APPLICATION OF CANONICAL APPROACHES. CANONICAL APPROACHES DEMONSTRATE THAT FOR A CLASS OF MOLECULES, THEIR PESS HAVE THE SAME SHAPE. WHAT APPEARS TO BE DIFFERENT SHAPES ON THE PESS IS A MATTER OF SCALING. CANONICAL APPROACHES WILL ALLOW FOR COMPUTATIONALLY INEXPENSIVE AND HIGHLY ACCURATE MOLECULAR DYNAMICS SIMULATIONS, WHICH ARE ESSENTIAL TO STUDY FUNDAMENTAL CHEMICAL DYNAMICS PROCESSES. THE INSIGHTS GAINED FROM THIS PROJECT WILL TAKE US A STEP CLOSER TO UNIFYING MODELS FOR GAS AND CONDENSED-PHASE CHEMICAL PROCESSES. THE OUTCOMES OF THIS WORK WILL GIVE A FUNDAMENTAL UNDERSTANDING OF THE COLLISIONAL ENERGY TRANSFER AND CHEMICAL REACTIONS WHERE THE ISOLATED BINARY COLLISION APPROXIMATION BREAKS DOWN. THIS PROJECT IS A UNIQUE RESEARCH OPPORTUNITY FOR UNDERGRADUATE STUDENTS AT FERRIS STATE UNIVERSITY. RESEARCH IS AN ESSENTIAL PART OF UNDERGRADUATE EDUCATION THAT PROVIDES GROWTH, DEVELOPMENT, AND TRAINING. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

DEPARTMENT OF DEFENSE CYBER SCHOLARSHIP PROGRAM AND DOD CYBER AND DIGITAL SERVICES ACADEMY GRANTS: FERRIS STATE UNIVERSITY

RURAL COMMUNITIES OPIOID RESPONSE (PLANNING)

COLLABORATIVE RESEARCH: A NATIONAL CONSORTIUM FOR SYNERGISTIC UNDERGRADUATE MATHEMATICS VIA MULTI-INSTITUTIONAL INTERDISCIPLINARY TEACHING PARTNERSHI

WAR, REVOLUTION, AND EMPIRE: U.S.-RUSSIAN/SOVIET RELATIONS, 1776-PRESENT

COLLABORATIVE RESEARCH: NORMALIZING ETHICAL REASONING IN MATHEMATICS AS A FOUNDATION FOR ETHICAL STEM -MATHEMATICIANS, WITH SOME EXCEPTIONS, HAVE NOT DESCRIBED WHAT IT MEANS TO PRACTICE AND USE MATHEMATICS ETHICALLY. THIS HAS CONTRIBUTED TO A CULTURE PERMISSIVE OF DATA-RELATED SCANDALS, QUESTIONABLE PROFESSIONAL PRACTICES, AND DECREASED PUBLIC TRUST IN SCIENCE. BY INTEGRATING ETHICAL REASONING (ER) INTO UNDERGRADUATE MATHEMATICS CLASSES, THE MATHEMATICS COMMUNITY CAN BEGIN TO ALTER THE PERCEPTION THAT, IF MATHEMATICS FEATURES ABSTRACT AND THEORETICAL CONSTRUCTS, THEN THE MATHEMATICS PRACTITIONER HAS NO ETHICAL RESPONSIBILITY. CONSIDERING THE ?MATHEMATICS PRACTITIONER? TO BE BOTH THE USER OF, AND THE CONTRIBUTOR TO, MATHEMATICS, THIS PROPOSAL SEEKS TO ESTABLISH ER AS A REGULAR COMPONENT OF MATHEMATICAL PRACTICE. RATHER THAN WAIT UNTIL PRACTITIONERS HAVE COMMITTED TO A CAREER IN RESEARCH, THIS PROJECT TARGET INSTRUCTORS OF, AND STUDENTS IN, MATH COURSES (SUCH AS CALCULUS, DIFFERENTIAL EQUATIONS, AND LINEAR ALGEBRA) THAT ARE FOUNDATIONAL FOR DIVERSE STEM FIELDS AND SEEK TO INTRODUCE A LEARNABLE, IMPROVABLE SKILL SET (ER). THE PROJECT BUILDS ON A PUBLISHED, DEVELOPMENTAL MODEL OF ETHICAL REASONING AND A NATIONAL SURVEY OF MATHEMATICS PRACTITIONERS? PERCEPTIONS OF ASPECTS OF ETHICAL PRACTICE THAT WERE DERIVED FROM MATHEMATICS, STATISTICS, AND COMPUTING (THE RESULTS OF WHICH WE REFER TO AS THE ?PROTO-GUIDELINES?) USING THIS FOUNDATION, THE PROJECT SEEKS TO FOSTER INTEGRITY IN BOTH THE USE OF, AND CONTRIBUTION TO, MATHEMATICS. THE PROJECT WILL INVITE INTERESTED PARTICIPANTS TO A WORKSHOP IN YEAR 1 TO DEVELOP LEARNING OUTCOMES FEATURING ER IN THEIR RESPECTIVE MATHEMATICS COURSE CONTEXTS AND TO DRAFT SUPPORTIVE TEACHING MATERIALS. THROUGHOUT YEAR 2, PARTICIPANTS WILL SHARE THEIR WORK WITH STAKEHOLDERS, INCLUDING NON-INSTRUCTOR STAKEHOLDERS THROUGH FOCUS GROUPS WITH BUSINESS, INDUSTRY, AND GOVERNMENT ABOUT THEIR PERCEPTIONS OF BUILDING ER CAPABILITIES IN USERS OF, AND CONTRIBUTORS TO, MATHEMATICS. THIS INPUT WILL BE USEFUL IN FORMULATING AUTHENTIC PROBLEMS THAT INSTRUCTORS CAN USE AND REFINE. IN YEAR 3, PARTICIPANTS WILL ATTEND NATIONAL AND REGIONAL WORKSHOPS WHERE INSTRUCTORS OF OTHER FOUNDATIONAL MATHEMATICS COURSES, AND AT DIFFERENT STUDENT LEVELS, CAN ADAPT THE TESTED ER INSTRUCTION MATERIALS TO PROMOTE IMPLEMENTATION AMONG A BROADER SET OF LEARNERS. DATA COLLECTED WILL INCLUDE SURVEY DATA FROM MATERIALS IMPLEMENTATION, QUALITATIVE DATA RELATED TO THE DEVELOPMENT AND IMPLEMENTATION OF THE MATERIALS, AND SURVEYS AND INTERVIEWS OF PROJECT STAKEHOLDERS. DATA WILL BE ANALYZED USING A QUALIFIED CHANGE ALGORITHM. THIS PROJECT SERVES THE NATIONAL INTEREST IN THE FAITH AND TRUST THE PUBLIC PUTS IN THE RESULTS OF STEM RESEARCH, INCLUDING BOTH THAT WHICH IS PART OF MATHEMATICS AND THAT WHICH INVOLVES THE USE OF MATHEMATICS. THIS PROJECT IS JOINTLY FUNDED BY THE IMPROVING UNDERGRADUATE STEM EDUCATION AND ETHICAL AND RESPONSIBLE RESEARCH PROGRAMS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

TO SUPPORT THE U.S. PREMIERE OF AN EXHIBITION FEATURING THE WORK OF ARTISTS WITH DISABILITIES.

THE JIM CROW MUSEUM OF RACIST MEMORABILIA AT FERRIS STATE UNIVERSITY WILL UNDERTAKE A COLLECTIONS DIGITIZATION PROJECT TO INCREASE ACCESS TO MUSEUM CONTENT. PROJECT ACTIVITIES INCLUDE UPGRADING TO A NEW CLOUD-BASED COLLECTIONS MANAGEMENT SYSTEM THAT ALLOWS PUBLIC ACCESS, MIGRATING EXISTING COLLECTIONS DATA TO THE NEW SYSTEM, ADDING NEW DIGITAL ASSETS TO THE COLLECTIONS DATABASE, AND CREATING A DIGITAL EXHIBIT AND VIRTUAL GALLERY TOURS. THE NEW, PUBLICLY ACCESSIBLE DATABASE AND ASSOCIATED DIGITAL EXHIBIT AND VIRTUAL GALLERY TOURS WILL ENABLE SCHOLARS, STUDENTS, EDUCATORS, AND COMMUNITIES WHO MAY NOT LIVE NEAR THE MUSEUM TO ACCESS THE MUSEUM'S COLLECTIONS CONTENT.

TO SUPPORT AN EXHIBITION JUXTAPOSING THE CIVIL RIGHTS-ERA PHOTOGRAPHY OF BRUCE DAVIDSON WITH CONTEMPORARY PHOTOGRAPHY DOCUMENTING THE BLACK LIVES MATTER MOVEMENT.

TO SUPPORT "HERE + NOW," A SERIES OF SOLO EXHIBITIONS, PERFORMANCES, COMMUNITY OUTREACH EVENTS, AS WELL AS A CATALOG.

COLLABORATIVE RESEARCH: FOUNDATIONAL COMMUNITY-BASED RESEARCH FOR ETHICS IN MATHEMATICS

PRESERVATION ASSESSMENT AND STEWARDSHIP PLANNING

TO SUPPORT THE EXHIBITION TRANSITIONS: NEW PHOTOGRAPHY FROM BANGLADESH.

NSL - BACCALAUREATE NURSING - LOAN GRANT WITH FUNDS FOR NEW BUDGET PERIOD

NSL - BACCALAUREATE NURSING - PD CHANGES

TERMINATE GRANT ACTION

HPSL - PHARMACY - PD CHANGES

SL - OPTOMETRY - PD CHANGES

TO SUPPORT AN EXHIBITION EXPLORING AFROFUTURISM AND FEMINISM AND RELATED PUBLIC PROGRAMMING.