Regents Of The University Of Michigan

HEALTH AND RETIREMENT STUDY

UNIVERSITY OF MICHIGAN COMPREHENSIVE CANCER CENTER SUPPORT GRANT

DRUG USE AND LIFESTYLES OF AMERICAN YOUTH

INSTITUTIONAL PORTION OF THE HIGHER EDUCATION EMERGENCY RELIEF FUND FORMULA GRANTS AUTHORIZED BY SECTION 18004(A)(1) OF THE CORONAVIRUS AID, RELIEF, AND ECONOMIC SECURITY (CARES) ACT

EMERGENCY FINANCIAL AID GRANTS TO STUDENTS UNDER THE CORONAVIRUS AID, RELIEF, AND ECONOMIC SECURITY (CARES) ACT

MICHIGAN INSTITUTE FOR CLINICAL AND HEALTH RESEARCH (MICHR)

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

MICHIGAN INSTITUTE FOR CLINICAL AND HEALTH RESEARCH (MCHR)

THE NATIONAL DEMENTIA WORKFORCE STUDY - ABSTRACT: OVERALL THE NATIONAL DEMENTIA WORKFORCE STUDY (NDWS) WILL BE LAUNCHED BY A NATIONAL TEAM OF EXPERTS IN CLINICAL CARE OF PERSONS LIVING WITH DEMENTIA, SURVEY RESEARCH, AND HEALTH WORKFORCE RESEARCH. THE GOAL OF THE NDWS DATA INFRASTRUCTURE IS TO ALLOW RESEARCHERS AND POLICYMAKERS TO ASK AND ANSWER SCIENTIFIC QUESTIONS TO HELP BUILD THE WORKFORCE OF CLINICIANS AND OTHER PROFESSIONAL CARE PROVIDERS REQUIRED BY THE GROWING POPULATION OF PERSONS LIVING WITH DEMENTIA IN THE U.S. THE CORE OF NDWS WILL BE FOUR SURVEYS THAT REFLECT KEY ELEMENTS OF THE PROFESSIONAL DEMENTIA CARE WORKFORCE IN THE U.S.: COMMUNITY CLINICIANS, NURSING HOME STAFF, HOME CARE STAFF, AND ASSISTED LIVING STAFF. IN ADDITION TO THESE SURVEYS, THE NDWS TEAM WILL DEVELOP A VARIETY OF ADDITIONAL DATA SOURCES THAT CAN BE LINKED WITH THE SURVEYS IN ORDER TO MAXIMIZE THE SCIENTIFIC POTENTIAL OF THE SURVEYS. THE NDWS TEAM INCLUDES THE COUNTRY’S LEADING DEMENTIA CARE, WORKFORCE, AND SURVEY RESEARCHERS AS CO-INVESTIGATORS AND CONSULTANTS, AND THE PROJECT’S ACTIVITIES WILL BE CONDUCTED THROUGH FIVE CORES: 1) ADMINISTRATIVE (LEAD: DONOVAN MAUST, MD, MS, AND CO-LEAD: JOANNE SPETZ, PHD); 2) SCREENING AND SURVEY INSTRUMENT DEVELOPMENT (CO-LEADS: JOANNE SPETZ, PHD, AND JAMES WAGNER, PHD); 3) ADMINISTRATIVE DATA TRANSFER, MASKING, ACCESS, AND ETHICS (LEAD: STEVEN MARCUS, PHD); 4) DATA COLLECTION, LINKAGES, CLEANING, AND SHARING (LEAD: JAMES WAGNER, PHD); AND 5) RESEARCH STUDIES (LEAD: LAURA WAGNER, PHD, RN). THE OVERALL AIMS ARE TO: 1) LAUNCH A FAMILY OF FOUR NATIONALLY REPRESENTATIVE PROFESSIONAL DEMENTIA WORKFORCE SURVEYS COVERING THE KEY CARE DELIVERY SETTINGS IN THE U.S.; 2) THROUGH THE NATIONAL DEMENTIA WORKFORCE STUDY, BUILD A DATA INFRASTRUCTURE SURROUNDING THE DEMENTIA WORKFORCE SURVEYS THAT ALLOWS RESEARCHERS TO GENERATE CRITICAL INSIGHTS INTO THE PROFESSIONAL DEMENTIA CARE WORKFORCE AND ASSOCIATED OUTCOMES FOR PLWD; AND 3) DEVELOP AND EXPAND THE COMMUNITY OF RESEARCHERS FOCUSED ON THE PROFESSIONAL DEMENTIA CARE WORKFORCE OVERALL AND THAT USE THE NATIONAL DEMENTIA WORKFORCE STUDY DATA INFRASTRUCTURE.

AWARD OF BASE AGREEMENT, INCLUDES FIVE AREAS OF TECHNOLOGY: -VEHICLE DYNAMICS, CONTROL, & ADAPTIVE BEHAVIOR, -HUMAN-CENTERED DESIGN & HUMAN-AUTONOMY

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP) -THE NATIONAL SCIENCE FOUNDATION (NSF) GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP) IS A HIGHLY COMPETITIVE, FEDERAL FELLOWSHIP PROGRAM. GRFP HELPS ENSURE THE VITALITY AND DIVERSITY OF THE SCIENTIFIC AND ENGINEERING WORKFORCE OF THE UNITED STATES. THE PROGRAM RECOGNIZES AND SUPPORTS OUTSTANDING GRADUATE STUDENTS WHO ARE PURSUING RESEARCH-BASED MASTER'S AND DOCTORAL DEGREES IN SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS (STEM) AND IN STEM EDUCATION. THE GRFP PROVIDES THREE YEARS OF FINANCIAL SUPPORT FOR THE GRADUATE EDUCATION OF INDIVIDUALS WHO HAVE DEMONSTRATED THEIR POTENTIAL FOR SIGNIFICANT RESEARCH ACHIEVEMENTS IN STEM AND STEM EDUCATION. THIS AWARD SUPPORTS THE NSF GRADUATE FELLOWS PURSUING GRADUATE EDUCATION AT THIS GRFP INSTITUTION. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

MICHIGAN INSTITUTE FOR CLINICAL AND HEALTH RESEARCH (MICHR) (UL1)

MICHIGAN INSTITUTE FOR CLINICAL AND HEALTH RESEARCH (MICHR) - PROJECT SUMMARY/ABSTRACT THE MICHIGAN INSTITUTE FOR CLINICAL & HEALTH RESEARCH (MICHR) CATALYZES CLINICAL AND TRANSLATIONAL RESEARCH (CTR) AND ADVANCES CLINICAL AND TRANSLATIONAL SCIENCE (CTS) AT THE UNIVERSITY OF MICHIGAN (U-M), THROUGHOUT THE STATE OF MICHIGAN, AND NATIONALLY. WE HAVE TRANSFORMED CTR AT U-M AND HAVE BEEN A COLLABORATIVE PARTNER WITH UNIVERSITY UNITS, MICHIGAN COMMUNITIES, AND THE CLINICAL AND TRANSLATIONAL SCIENCE AWARD (CTSA) CONSORTIUM. IN THE NEXT SEVEN YEARS, MICHR WILL ACHIEVE GREATER INNOVATION, DIVERSITY, EFFICIENCY, EQUITY, QUALITY, INCLUSION, AND REACH IN CTR AND DEVELOP, DEMONSTRATE, AND DISSEMINATE GENERALIZABLE CTS INNOVATIONS. THIS VISION COMPRISES FIVE STRATEGIC GOALS: 1) EXPAND THE DIVERSITY OF VOICES DRIVING THE STRATEGIC DIRECTION OF CTR AND CTS. WITH OUR COMMUNITY PARTNERS, WE WILL CO-DEVELOP STRATEGIES TO ELEVATE DIVERSE VOICES IN CTS LEADERSHIP. THE MICHIGAN COMMUNITY EQUITY REVIEW BOARD WILL ENSURE INTEGRATION OF COMMUNITY VOICE AND CULTURE IN RESEARCH THROUGHOUT THE STATE. THE PATIENTS AS PARTNERS PROGRAM WILL ENGAGE PATIENTS IN STUDY DEVELOPMENT AND MENTORING. 2) EXTEND CTR TO THE STATE AND INCREASE ENGAGEMENT WITH NATIONAL CTR THROUGH CTS INNOVATIONS. WE WILL INCREASE ACCESS TO RESEARCH BY DEVELOPING CTR CAPACITY STATEWIDE. THE M- REACH PLATFORM WILL FACILITATE COMMUNITY-ACADEMIC CONNECTIONS. THE NETWORK CONNECTOR WILL CONNECT STUDY TEAMS, NATIONAL NETWORKS, AND UNIVERSITY PARTNERS. 3) ENGAGE NEW GROUPS IN CTR AND CTS THROUGH NEW PATHWAYS AND SUPPORTS. WE WILL SUPPORT THE CTR WORKFORCE STATEWIDE THROUGH NEW TRAININGS, MENTORING PROGRAMS, APPRENTICESHIPS, AND COMMUNITIES OF PRACTICE. WE WILL DEVELOP RESEARCH TRAINING PROGRAMS TAILORED TO CLINICAL PRACTICE-FOCUSED PHYSICIANS. STUDY TEAMS WILL INCLUDE COMMUNITY MEMBERS AND PATIENTS AND BE SUPPORTED BY TEAM SCIENCE INITIATIVES AND PILOT GRANT FUNDING. 4) EXTEND TRANSLATION THROUGH DISSEMINATION AND IMPLEMENTATION SCIENCE AND APPLICATION. THE DISSEMINATION & IMPLEMENTATION CATALYST WILL ADVANCE THE SCIENCE AND APPLICATION OF DISSEMINATION AND IMPLEMENTATION FOR CTR AND CTS. WITH OUR COMMUNITY PARTNERS, WE WILL CO-DEVELOP TOOLS FOR EFFECTIVE ACADEMIC-COMMUNITY RESEARCH PARTNERSHIPS DURING A PUBLIC HEALTH EMERGENCY. WE WILL ENABLE RAPID TRANSLATION OF IDEAS INTO ACTIONABLE SOLUTIONS THROUGH HUMAN-CENTERED DESIGN. 5) EXTEND MICHR SERVICES TO ADVANCE INNOVATION, QUALITY, AND EFFICIENCY OF DIVERSE TYPES OF CTR. WE WILL HELP ACADEMICS AND COMMUNITY MEMBERS DEVELOP SKILLS IN THE SCIENCE OF COMMUNITY-ENGAGED RESEARCH. WE WILL DEVELOP TRAINING PROGRAMS AND TOOLS AS WELL AS EXTEND AND ADAPT OUR SERVICES TO ENSURE RIGOR AND EFFICIENCY OF HEALTH-RELATED BEHAVIORAL AND SOCIAL SCIENCE RESEARCH. WE WILL ADD NEW FEATURES TO OUR ELECTRONIC MEDICAL RECORD SEARCH ENGINE AND OUR PARTICIPANT RECRUITMENT PLATFORM TO INCREASE INCLUSIVITY. WE WILL DETERMINE COST- EFFECTIVENESS AND EFFECT ON CLINICAL TRIAL PERFORMANCE OF STRATEGIES FOR IMPROVING PROTOCOL QUALITY. IN SUMMARY, MICHR IS POISED TO ENTER ITS THIRD DECADE OF ADVANCING CTR AND CTS THROUGHOUT MICHIGAN AND THE NATION.

A COHORT-SEQUENTIAL PANAL STUDY OF DRUG USE, AGES 19-50

TAS::89 0227::TAS RECOVERY; NEW: RECOVERY ACT - EFRC: SOLAR ENERGY CONVERSION IN COMPLEX MATERIALS (SECCM) -- EFRC; PI - PETER GREEN

PROPOSAL TO STUDY THE PROPERTIES AND INTERACTIONS OF ELEMENTARY PARTICLES

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

MID-SCALE RI-2: THE RESEARCH DATA ECOSYSTEM (RDE), A NATIONAL RESOURCE FOR REPRODUCIBLE, ROBUST, AND TRANSPARENT SOCIAL SCIENCE RESEARCH IN THE 21ST CENTURY -THIS PROJECT WILL IMPLEMENT A NEW PLATFORM FOR SOCIAL AND BEHAVIORAL SCIENCE DATA. DIVERSE TYPES OF DATA ENABLE PATH-BREAKING ANALYSES INTO HUMAN BEHAVIOR BUT ALSO PRESENT CHALLENGES OF SCALE, SENSITIVITY, AND STRUCTURE. CURRENT BARRIERS TO CONDUCTING RESEARCH INCLUDE MULTIPLE INCOMPATIBLE STANDARDS FOR DATA, LACK OF INTEROPERABILITY, AND THE INHERENT DIFFICULTY OF MANAGING BIG DATA. THERE IS AN URGENT NEED FOR NEW MODES OF ACCESS, CONFIDENTIALITY PROTECTION, METHODOLOGICAL APPROACHES, AND TOOLS SO THAT RESEARCH USING A VARIETY OF DATA TYPES MEETS ACCEPTED SCIENTIFIC STANDARDS. THE RESEARCH DATA ECOSYSTEM (RDE) WILL MODERNIZE THE MANAGEMENT OF DATA TO ENABLE A NEW ERA OF INTERCONNECTED RESEARCH FOR THE SOCIAL AND BEHAVIORAL SCIENCES. THE PLATFORM WILL IMPROVE THE QUALITY OF DATA-DRIVEN SOCIAL AND BEHAVIORAL SCIENCE RESEARCH OVER THE ENTIRE DATA LIFE CYCLE. RDE WILL ENABLE RESEARCHERS ACROSS DISCIPLINES TO CONDUCT THEIR WORK MORE EFFICIENTLY AND TO CREATE, ORGANIZE, ARCHIVE, ACCESS, AND ANALYZE DATA IN WAYS THAT THEY CANNOT WITH EXISTING INFRASTRUCTURE. RDE WILL MAKE SOCIAL AND BEHAVIORAL DATA MORE USABLE OUTSIDE OF ACADEMIA BY MAKING IT MORE FINDABLE AND ACCESSIBLE. THE PROJECT WILL PROVIDE TRAINING OPPORTUNITIES FOR GRADUATE AND UNDERGRADUATE STUDENTS AND WILL BROADEN AND DIVERSIFY PARTICIPATION IN THE SOCIAL AND BEHAVIORAL SCIENCES BY REMOVING TECHNICAL BOTTLENECKS TO RESEARCH. THIS PROJECT IS SUPPORTED BY THE FOUNDATION-WIDE MID-SCALE RESEARCH INFRASTRUCTURE PROGRAM. THIS PROJECT WILL DEVELOP AN INTEGRATED SUITE OF SOFTWARE TO ADVANCE RESEARCH IN THE SOCIAL AND BEHAVIORAL SCIENCES. RDE WILL ENABLE: 1) INTEROPERABILITY: AN INTEGRATED SYSTEM FOR THE ENTIRE RESEARCH DATA LIFECYCLE, SO THAT WORK DONE EARLY IN THE DATA LIFECYCLE IS USEFUL AT LATER STAGES, MAKING IT POSSIBLE TO INTEGRATE DATA FROM DIFFERENT SOURCES, 2) REPRODUCIBILITY: MAKING IT EASIER TO REPRODUCE AND BUILD ON PRIOR RESEARCH RESULTS BY BEING ABLE TO FIND AND RE-USE DATA AND CODE, 3) TRANSPARENCY: PROVIDING INFORMATION ABOUT PROVENANCE, INCLUDING SOURCE, CODE, METHOD OF COLLECTION, ETC. FOR RESEARCH DATA, 4) INCREASED EFFICIENCY OF DATA SHARING: REDUCING BURDEN ON DATA PRODUCERS IN SHARING DATA AND ENSURING THAT SHARED DATA ARE FAIR (FINDABLE, ACCESSIBLE, INTEROPERABLE, REUSABLE), AND 5) CONFIDENTIALITY PROTECTION: PROTECTING CONFIDENTIALITY WHILE INCREASING RESEARCH ACCESS. TO ACHIEVE THESE GOALS, THE PROJECT WILL DEVELOP THE RESEARCH DATA DESCRIPTION FRAMEWORK, A METADATA SPECIFICATION SIMILAR TO THE RESOURCE DESCRIPTION FRAMEWORK, FOR DESCRIBING DIFFERENT RESEARCH DATA LIFECYCLE EVENTS. RDE WILL INCLUDE STAND-ALONE FUNCTIONAL COMPONENTS FOR EACH STAGE OF THE RESEARCH LIFECYCLE THAT WILL BE INTEROPERABLE WITH ONE ANOTHER AND WITH KEY EXISTING RESEARCH INFRASTRUCTURE. THE PLATFORM WILL SUPPORT SOCIAL AND BEHAVIORAL SCIENCE RESEARCHERS USING TRADITIONAL (E.G., SURVEY AND EXPERIMENTAL) AND NOVEL (E.G., DIGITAL TRACE, IMAGING) TYPES OF DATA OVER THE ENTIRE RESEARCH LIFECYCLE, FROM DATA COLLECTION TO ANALYSIS TO SHARING TO RE-DISCOVERY AND RE-ANALYSIS. THIS INFRASTRUCTURE WILL IMPROVE THE QUALITY, INTEGRITY, AND SAFETY OF DATA WHILE INCREASING ACCESSIBILITY TO DATA AND COLLABORATION BETWEEN USERS ACROSS ALL SOCIAL SCIENCE AND SOME BEHAVIORAL SCIENCE DISCIPLINES. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

BRAIN OXYGEN OPTIMIZATION IN SEVERE TRAUMATIC BRAIN INJURY - PHASE 3 (BOOST-3)

TRANSITIONS FROM PRESCHOOL THROUGH HIGH SCHOOL: FAMILY, SCHOOLS & NEIGHBORHOODS

SLEEP FOR STROKE MANAGEMENT AND RECOVERY TRIAL (SLEEP SMART)

MICHIGAN-PITTSBURGH-WYSS REGENERATIVE MEDICINE RESOURCE CENTER: ADVANCING DENTAL, ORAL, AND CRANIOFACIAL REGENERATION TO CLINICAL TRIAL INITIATION

HEALTH, WEALTH, AND WELLBEING OVER THE LIFE COURSE AND ACROSS GENERATIONS

CENTER FOR THE ASSESSMENT OF THE PUBLIC HEALTH IMPACT OF TOBACCO REGULATIONS

BILIARY ATRESIA CONSORTIUM: DATA COORDINATING CENTER

HIGH ENERGY PHYSICS AT THE UNIVERSITY OF MICHIGAN

NEUROLOGICAL EMERGENCIES TREATMENT TRIALS NETWORK: CLINICAL COORDINATING CENTER

THE UNIVERSITY OF MICHIGAN EDUCATION AND RESEARCH CENTER

SOFTWARE CENTER FOR PREDICTIVE THEORY AND MODELING

ANALYSIS AND CHARACTERIZATION OF TRAUMA-INDUCED COAGULOPATHY

ACCELERATE NOAA'S MISSION IN THE GREAT LAKES BY (1) CONDUCTING PRIMARY RESEARCH NEEDED TO MEET KEY SCIENTIFIC CHALLENGES FACED IN MANAGING THE LAURENTIAN GREAT LAKES, (2) INCREASING THE IMPACTS OF RESEARCH BY FOSTERING ENGAGEMENT WITH RESOURCE MANAGERS AND DECISION-MAKERS THAT HELP TURN SCIENCE INTO ACTION, (3) PROVIDING CUTTING-EDGE CAREER TRAINING THAT PREPARES A DIVERSE AND ADAPTABLE WORKFORCE OF SOCIAL SCIENTISTS, NATURAL SCIENTISTS, ENGINEERS AND DESIGN EXPERTS TO BE THE NEXT GENERATION OF RESEARCHERS AND PRACTITIONERS ON THE GREAT LAKES, AND (4) PROMOTING PUBLIC LITERACY ABOUT THE GREAT LAKES WITH A COORDINATED OUTREACH AND COMMUNICATIONS PROGRAM ACROSS THE REGION.

UNIVERSITY OF MICHIGAN PROJECT: CONSORTIUM FOR MONITORING, TECHNOLOGY, AND VERIFICATION. BASE MOD FULLY FUNDS YEAR 1 OF THE BUDGET.

CONSORTIUM FOR VERIFICATION TECHNOLOGY

ABCD-USA CONSORTIUM: RESEARCH PROJECT

THE COOPERATIVE INSTITUTE FOR GREAT LAKES RESEARCH (CIGLR): A PROPOSAL TO THE OFFICE OF OCEANIC AND ATMOSPHERIC RESEARCH, NOAA, FOR A NEW REGIONAL RE

1/2 ICECAP: INFLUENCE OF COOLING DURATION ON EFFICACY IN CARDIAC ARREST PATIENTS

MICHIGAN MEDICAL SCIENTIST TRAINING PROGRAM

PREDICTING CARIES RISK IN UNDERSERVED TODDLERS IN PRIMARY HEALTHCARE SETTINGS

THE BIOLOGY OF PROSTATE CANCER SKELETAL METASTASES

PREDICTIVE CONTROL OF PLASMA KINETICS: MULTI-PHASE AND BOUNDED SYSTEMS

MICHIGAN DIABETES RESEARCH CENTER

SPORE IN PROSTATE CANCER

COVID 19: INSTITUTIONAL PORTION OF HEERF FORMULA GRANTS UNDER THE CARES ACT - DEARBORN

LABORATORY FOR ANTI-GERIC TESTING, EVALUATION AND RESEA*

CENTER FOR STRUCTURAL BIOLOGY OF HIV RNA - THIS APPLICATION FOR THE CENTER FOR STRUCTURAL BIOLOGY OF HIV RNA (CRNA) FOCUSES ON DETERMINING THE STRUCTURAL AND MECHANISTIC BASES OF HIV-1 RNA-RELATED REPLICATION FUNCTIONS AND THE HOST’S RESPONSE AT THE CELLULAR, VIRAL, AND ATOMIC LEVELS. ALTHOUGH CONSIDERABLE PROGRESS HAS BEEN MADE OVER THE PAST 40 YEARS IN UNDERSTANDING HOW PROTEINS FUNCTION IN HIV-1 REPLICATION, COMPARATIVELY LITTLE IS KNOWN ABOUT HOW HIV-1 RNA STRUCTURES, DYNAMICS, TRAFFICKING, AND INTERACTIONS WITH PROTEINS ALTERNATELY ENABLE OR LIMIT VIRUS REPLICATION. THE PAST DECADE HAS PROVIDED TRANSFORMATIVE EXAMPLES OF THE THERAPEUTIC USE OF RNA AND RNA-TARGETED THERAPIES, AND RECENT PROGRESS BY MEMBERS OF THE PROPOSED TEAM HAS BEGUN TO UNLOCK STRUCTURAL AND DYNAMIC FEATURES OF RNA ELEMENTS IN HIV-1. BECAUSE HIV-1 RNA IS EXCEPTIONALLY RICH IN BIOLOGIC FUNCTIONS, THE POTENTIAL FOR RNA-TARGETED APPROACHES IN THE PREVENTION, MAINTENANCE, AND CURE OF HIV-1 DISEASE IS HIGHLY COMPELLING. HOWEVER, THIS POTENTIAL IS LIMITED BY THE GENERAL PAUCITY OF HIGH-RESOLUTION STRUCTURAL INFORMATION FOR RNA AND PROTEIN-RNA COMPLEXES, WHICH REFLECTS INHERENT CHALLENGES IN USING RNA AS A SUBJECT FOR STRUCTURAL ANALYSIS AND THE INADEQUACY OF TRADITIONAL BIOPHYSICAL APPROACHES TO ADDRESS THESE CHALLENGES. THE CRNA WILL FACE THESE CHALLENGES FOR HIV-1 RNA WITH ITS MULTIDISCIPLINARY TEAM OF STRUCTURAL BIOLOGISTS, CHEMISTS, CELL AND COMPUTATIONAL BIOLOGISTS, BIOCHEMISTS, IMMUNOLOGISTS, AND VIROLOGISTS. MANY ARE LEADERS IN THE STUDY OF HIV-1 RNA AND THE ROLES OF ITS STRUCTURES IN VIRUS REPLICATION, WHILE OTHERS ARE NEW TO THE HIV-1 FIELD AND BRING A FRESH PERSPECTIVE AND COMPLEMENTARY EXPERTISE. TOGETHER, THIS TEAM BRINGS CUTTING EDGE TECHNOLOGIES AND INCISIVE BIOLOGIC APPROACHES TO OVERCOME CURRENT TECHNOLOGICAL OBSTACLES, ENABLING MECHANISTIC DETERMINATION OF THE ROLE OF HIV- 1 RNA STRUCTURES AND ASSOCIATED PROTEINS IN VIRAL TRANSCRIPTION, SPLICING, TRANSLATION, PACKAGING, PARTICLE ASSEMBLY, AND INTERACTIONS WITH HOST FACTORS. THESE STUDIES WILL ENABLE THE CRNA TO ADVANCE GOALS OF CLINICAL RELEVANCE, INCLUDING THE DEVELOPMENT NEW RNA-CENTERED STRATEGIES FOR TREATING HIV-1, THE REACTIVATION OF LATENT PROVIRUSES AS A POTENTIAL APPROACH FOR ERADICATING HIV-1 INFECTION, AND THE AUGMENTATION OF HOST DEFENSES AGAINST HIV-1 INFECTION. THE PROPOSED STUDIES WILL ALSO RESULT IN THE DEVELOPMENT OF POWERFUL NEW COMPUTATIONAL, IMAGING, AND STRUCTURAL BIOLOGY TECHNOLOGIES THAT CAN BE APPLIED TO ALL AREAS OF RNA BIOLOGY.

THE CENTER FOR HIV RNA STUDIES (CRNA)

OPTIMIZATION OF HIGH DOSE CONFORMAL THERAPY

CLAUDE D.PEPPER OLDER AMERICANS INDEPENDENCE CENTERS

NEPHROTIC SYNDROME RARE DISEASE CLINICAL RESEARCH NETWORK

GRADUATE RESEARCH FELLOWSHIP PROGRAM

AWARDED WERE FUNDING FOR 28 PROJECTS UNDER THE CY14 BASE EFFORT FOR THE FOLLOWING THRUST AREAS: DYNAMICS AND CONTROL OF VEHICLES AND MOBILE ROBOTS,

LIFESTAGE EXPOSURES AND ADULT DISEASE

PHASE III (ARC III) MODELING AND SIMULATION OF GROUND VEHICLES

BRAIN TUMOR THERAPEUTIC EFFICACY OF QUANTITATIVE MR

CHILDHOOD LIVER DISEASE RESEARCH NETWORK DATA COORDINATING CENTER

CONTINUITY AND CHANGE IN AMERICAN ECONOMIC AND SOCIAL LIFE: THE PSID 2017-2020

NERRS SCIENCE COLLABORATIVE: A COMPREHENSIVE NATIONAL PROGRAM FOR END USER INFORMED ESTUARINE RESEARCH

CONTINUITY AND CHANGE IN AMERICAN ECONOMIC AND SOCIAL LIFE: THE PSID 2007-2011

A COLLABORATIVE SCIENCE PROGRAM FOR THE NATIONAL ESTUARINE RESEARCH RESERVE SYSTEM: CONNECTING WITH END USERS THROUGHOUT THE APPLIED RESEARCH PROCESS

UNIVERSITY OF MICHIGAN DATA COORDINATING CENTER FOR THE DIABETIC FOOT CONSORTIUM

NSF ZEUS MULTI-PETAWATT LASER FACILITY: OPERATIONS

PSID 2021-2024: CONTINUITY AND CHANGE IN AMERICAN ECONOMIC AND SOCIAL LIFE

1/2 PEDIATRIC INFLUENCE OF COOLING DURATION ON EFFICACY IN CARDIAC ARREST PATIENTS (P-ICECAP) - PROJECT SUMMARY OUT-OF-HOSPITAL CARDIAC ARREST (OHCA) IN CHILDREN IS A TRAGIC EVENT THAT USUALLY RESULTS IN DEATH OR PERMANENT BRAIN INJURY IN SURVIVORS. MORE THAN 7000 CHILDREN SUFFER OHCA EACH YEAR IN THE US AND IMPROVEMENTS IN PEDIATRIC OHCA OUTCOMES, JUST AS IN ADULTS, IS VERY MUCH LIMITED BY OUR ABILITY TO PROTECT THE BRAIN FROM GLOBAL CEREBRAL ISCHEMIC INJURY IN THOSE WHO ARE SUCCESSFULLY RESUSCITATED. TARGETED TEMPERATURE MANAGEMENT (TTM) IS CURRENTLY GUIDELINE-RECOMMENDED IN CHILDREN FOLLOWING OHCA WITH PREFERENCE STATED FOR THERAPEUTIC HYPOTHERMIA (TTM 32-34°C) OVER NORMOTHERMIA (TTM 36-37.5°C) IN ORDER TO PREVENT FEVER WHICH COULD AMPLIFY BRAIN INJURY. THE OPTIMAL DURATION AND PATIENT SELECTION CRITERIA FOR THERAPEUTIC HYPOTHERMIA IN CHILDREN REMAIN UNKNOWN AND COOLING DEVICES ARE NOT SPECIFICALLY FDA APPROVED FOR THIS INDICATION. PRECLINICAL DATA AND MECHANISTIC STUDIES STRONGLY SUGGEST THAT DURATIONS OF HYPOTHERMIA LONGER THAN THOSE TYPICALLY USED IN ADULTS MAY MINIMIZE BRAIN INJURY. THIS STUDY WILL DETERMINE IF IDENTIFYING AN OPTIMAL DURATION (DOSE) OF THERAPEUTIC HYPOTHERMIA CAN IMPROVE OUTCOMES, AND IF DEVELOPMENT OF A DURATION RESPONSE CURVE CAN CONFIRM EFFICACY IN A WIDER PEDIATRIC POPULATION OF OHCA SURVIVORS. WE HYPOTHESIZE THAT LONGER DURATIONS OF COOLING WILL IMPROVE SURVIVAL AND RESULT IN BETTER NEUROLOGIC RECOVERY IN SURVIVORS COMPARED TO SHORTER COOLING DURATIONS, AS ASSESSED BY THE VINELAND ADAPTIVE BEHAVIOR SCALES–THIRD EDITION (VINELAND-3) SCORE. THE PRIMARY GOAL OF THIS PROJECT IS TO IDENTIFY CLINICAL STRATEGIES THAT WILL INCREASE THE NUMBER OF PATIENTS WITH IMPROVED NEUROLOGICAL RECOVERY FROM OHCA. THE RESULTS OF THIS TRIAL WILL BE EXTREMELY SIGNIFICANT IN CHILDREN AND WILL IMMEDIATELY IMPACT BOTH CLINICAL PRACTICE AND REGULATORY EVALUATION. THE PEDIATRIC INFLUENCE OF COOLING DURATION ON EFFICACY IN CARDIAC ARREST PATIENTS (P-ICECAP) TRIAL, MODELED AFTER THE ONGOING ADULT ICECAP TRIAL, USES INNOVATIVE ADAPTIVE DOSE FINDING METHODS THAT ALLOW EXPLORATION OF A WIDE RANGE OF POTENTIAL DURATIONS AND EFFICIENTLY ALLOCATE SUBJECTS WHERE THEY WILL BE MOST INFORMATIVE. THE STUDY WILL BE CONDUCTED USING RESOURCES OF THE NHLBI/NINDS STRATEGIES TO INNOVATE EMERGENCY CARE CLINICAL TRIALS NETWORK (SIREN), WHICH IS EXPERIENCED IN BOTH PEDIATRIC AND ADULT TRIALS, AND IS CURRENTLY CONDUCTING THE CURRENT ADULT ICECAP TRIAL. SIREN LEVERAGES EXISTING RESOURCES TO ACHIEVE ECONOMIES OF SCALE AND TO CONDUCT IMPORTANT CLINICAL INVESTIGATIONS SPANNING FROM PRE-HOSPITAL, THROUGH BOTH THE EMERGENCY DEPARTMENT AND ICU STAY, AND POST HOSPITAL DISCHARGE.

COMPASS: A COMPREHENSIVE MOBILE PRECISION APPROACH FOR SCALABLE SOLUTIONS IN MENTAL HEALTH TREATMENT - MATCHING PATIENTS TO THE TREATMENT MOST EFFECTIVE FOR THEM CAN ACCELERATE RECOVERY AND MEANINGFULLY REDUCE THE GROWING BURDEN OF MENTAL HEALTH CONDITIONS. KEY BARRIERS TO TAILORING CARE ARE THE LACK OF OBJECTIVE DATA THAT CAN PREDICT TREATMENT RESPONSE AND EFFECTIVE APPROACHES TO TRANSLATE DATA TO IMPROVED CLINICAL OUTCOMES. AS A RESULT, MANY PATIENTS EXPERIENCE MULTIPLE TREATMENT TRIALS BEFORE RECOVERY AND A SUBSTANTIAL PROPORTION DO NOT RECOVER. THE COMBINATION OF MOBILE BEHAVIORAL TRACKING AND MACHINE LEARNING HOLDS PROMISE TO OVERCOME THIS BARRIER. SMARTPHONES AND WEARABLE SENSORS CAN COLLECT PASSIVE, CONTINUOUS AND OBJECTIVE MEASURES AND CAN BE USED TO ADMINISTER SCALABLE, ACTIVE BEHAVIORAL TASKS THAT CAPTURE CONSTRUCTS CENTRAL TO MENTAL HEALTH. THESE HIGHLY DENSE DATA CAN BE COMBINED WITH GENOMICS AND CLINICAL RECORDS, AND MACHINE LEARNING HOLDS PROMISE TO EXTRACT MEANINGFUL SIGNALS FROM THESE RICH, MULTIDIMENSIONAL STREAMS OF INFORMATION AND FACILITATE THE DEVELOPMENT OF ACCURATE PREDICTIVE MODELS. OUR LONG-TERM GOAL IS TO INCREASE THE EFFECTIVENESS OF MENTAL HEALTH TREATMENTS AND THE CAPACITY OF OUR MENTAL HEALTH CARE SYSTEM. OUR OBJECTIVE IN THIS APPLICATION IS TO IDENTIFY FACTORS THAT CAN BE USED TO EFFECTIVELY MATCH PATIENTS TO TREATMENTS. WE WILL RECRUIT 4,400 PATIENTS INITIATING OUTPATIENT MENTAL HEALTH CARE IN A NETWORK OF PRIMARY AND SPECIALTY CLINICS INTO THE COMPASS STUDY (COMPREHENSIVE MOBILE PRECISION APPROACH FOR SCALABLE SOLUTIONS IN MENTAL HEALTH TREATMENT) AS PART OF THE IMPACT-MH PROGRAM. SUBJECTS WILL BE TRACKED THROUGH A WEARABLE DEVICE AND SMARTPHONE AND COMPLETE ACTIVE BEHAVIORAL TASKS. BECAUSE EVIDENCE-BASED DIGITAL INTERVENTIONS ARE INCREASINGLY WIDESPREAD, PATIENTS WILL FIRST BE FOLLOWED AS THEY ARE RANDOMIZED TO RECEIVE ONE OF TWO EVIDENCE-BASED DIGITAL INTERVENTIONS: COGNITIVE BEHAVIORAL THERAPY (CBT); OR 2) MINDFULNESS TRAINING. SUBSEQUENTLY, PATIENTS WILL BE FOLLOWED AS THEY RECEIVE THE ARRAY OF TREATMENTS SELECTED BY THEIR CLINICAL TEAMS. OUR OVERARCHING HYPOTHESIS IS THAT, THROUGH THE USE OF MOBILE TECHNOLOGY AND MACHINE LEARNING IN A LARGE COHORT BEFORE AND DURING MENTAL HEALTH CARE, WE CAN DEVELOP INDIVIDUALIZED PREDICTION MODELS THAT WILL OPTIMIZE MENTAL HEALTH TREATMENTS. OUR STUDY IS DESIGNED TO TEST THIS HYPOTHESIS WITH THE FOLLOWING SPECIFIC AIMS: (1) DEVELOP PREDICTIVE MODELS FOR PERSONALIZED DIGITAL INTERVENTION TREATMENT; (2) DEVELOP PREDICTIVE MODELS FOR PERSONALIZED, CLINIC-BASED MENTAL HEALTH TREATMENT; (3) ASSESS PATIENT AND CLINICIAN PREFERENCES FOR AND PERCEPTIONS OF, THE USE OF PREDICTIVE MODELING AND BEHAVIORAL TRACKING IN MENTAL HEALTH CARE; AND (4) ACTIVELY PARTICIPATE IN CROSS-IMPACT-MH PROJECT ACTIVITIES. OUR APPROACH IS INNOVATIVE BECAUSE IT APPLIES SCALABLE TECHNOLOGY AND ANALYTIC TOOLS TO A LARGE AND DIVERSE SAMPLE OF SUBJECTS RECEIVING TREATMENT UNDER REAL-WORLD CONDITIONS. FURTHER, THE PROJECT IS DESIGNED TO LEAD DIRECTLY TO AN ORGANIZATION-LEVEL INTERVENTION THAT MATCHES PATIENTS TO TREATMENTS. FINALLY, THIS PROJECT IS SIGNIFICANT BECAUSE IT HAS THE POTENTIAL TO GREATLY ACCELERATE RECOVERY BY IDENTIFYING THE TREATMENTS FROM WHICH EACH PERSON IS LIKELY TO DERIVE THE MOST BENEFIT.

NUTRITION AND OBESITY RESEARCH CENTERS

LOW-PASS SEQUENCING AND HIGH-DENSITY SNP GENOTYPING FOR TYPE 2 DIABETES

COVID 19: CARES ACT FUNDING-DEARBORN-19/20

MICHIGAN ALZHEIMER'S DISEASE RESEARCH CENTER - ABSTRACT – OVERALL FOUR YEARS AGO THE MICHIGAN ADRC (MADRC) WAS ESTABLISHED AS A NEW CONSORTIUM LINKING THE THREE MAJOR RESEARCH UNIVERSITIES IN MICHIGAN: UNIVERSITY OF MICHIGAN, MICHIGAN STATE UNIVERSITY, AND WAYNE STATE UNIVERSITY. SERVING THE ENTIRE STATE OF MICHIGAN, THE NEW MADRC ACHIEVED ITS MILESTONES IN WIDE-RANGING ACTIVITIES AND RESEARCH THAT EMPHASIZED A CENTRAL THEME: TO IDENTIFY, UNDERSTAND AND TREAT THE MYRIAD NON-SS- AMYLOID CONTRIBUTIONS TO BRAIN DYSFUNCTION AND DEGENERATION IN ALZHEIMER’S DISEASE AND RELATED DEMENTIAS (ADRD). WITH CONTINUED NIA SUPPORT, THE MADRC PROPOSES TO MAINTAIN THIS CENTRAL THEME BECAUSE IT CAPTURES THE DIVERSE EXPERTISE OF OUR DEMENTIA SCIENTISTS, SHEDS LIGHT ON ADRD HETEROGENEITY, AND REFLECTS THE EXPERIENCE OF THE RACIALLY DIVERSE POOL OF RESEARCH PARTICIPANTS ENGAGED IN MADRC-SPONSORED STUDIES. TO ACHIEVE ITS OBJECTIVES, THE MADRC HAS FOUR MAJOR AIMS: 1) CATALYZE AND PERFORM RESEARCH OF THE HIGHEST IMPACT IN ADRD; 2) PROMOTE REGIONAL EFFORTS TO UNDERSTAND, DIAGNOSE AND TREAT THE FULL SPECTRUM OF DEMENTIAS THROUGH COLLABORATIVE SCIENTIFIC AND OUTREACH EFFORTS; 3) PROVIDE TRAINING AND RESEARCH OPPORTUNITIES FOR HEALTH CARE PROFESSIONALS, SCIENTISTS, AND STUDENTS IN ADRD THROUGH INNOVATIVE EDUCATIONAL AND MENTORING PROGRAMS; AND 4) COLLABORATE WITH OTHER ADRCS, THE NACC, NCRAD, AND OTHER MULTI-CENTER EFFORTS TO LEAD THE FIELD IN DEVELOPING NEW DIAGNOSTIC AND THERAPEUTIC INTERVENTIONS FOR THESE DEVASTATING DISEASES. THE INTEGRATED EFFORTS OF SEVEN CORES, INCLUDING NEW NEUROIMAGING AND BIOMARKER CORES, WILL SUPPORT A WIDE RANGE OF BASIC, CLINICAL, TRANSLATIONAL AND HEALTH DISPARITIES RESEARCH ADVANCING THE FIELD TOWARD: IMPROVED UNDERSTANDING OF DISEASE MECHANISMS; MORE PRECISE DISEASE IDENTIFICATION ACROSS THE DEMENTIA SPECTRUM; DEVELOPMENT OF NOVEL BIOMARKERS; INCREASED KNOWLEDGE OF THE BASIS FOR HEALTH DISPARITIES THAT DISPROPORTIONATELY AFFECT BLACK AMERICANS; DEVELOPMENT OF NON-PHARMACOLOGICAL THERAPIES; AND THE IDENTIFICATION AND MODIFICATION OF DISEASE RISKS. THE RESEARCH EDUCATION COMPONENT (REC) WILL SERVE AS THE CENTERPIECE OF INNOVATIVE TRAINING OPPORTUNITIES SPANNING ALL THE CORES, AND A NEW LEADERS INITIATIVE WILL SUPPORT AND PROMOTE A DIVERSE GROUP OF NEXT-GENERATION LEADERS IN DEMENTIA RESEARCH. BENEFITTING FROM THE OUTSTANDING RESOURCES OF ALL THREE UNIVERSITIES AND STRONG MULTI-INSTITUTIONAL SUPPORT, THE MADRC IS POISED TO MAKE NEW DISCOVERIES, EDUCATE THE PUBLIC, AND TRAIN NEXT-GENERATION LEADERS AS WE SEEK TO ACHIEVE THE MILESTONES SET FORTH IN THE NATIONAL ALZHEIMER’S PROJECT ACT.

CENTER FOR COMPLEX PARTICLE SYSTEMS (COMPASS) -NONTECHNICAL DESCRIPTION: A COLLOID IS A MIXTURE CONSISTING OF INSOLUBLE PARTICLES OF ONE SUBSTANCE, SUSPENDED THROUGHOUT ANOTHER SUBSTANCE. THE ABILITY TO SHAPE SUCH PARTICLE-BASED MATTER HAS BEEN A CENTRAL ELEMENT IN THE DEVELOPMENT OF HUMAN CIVILIZATION. FOR EXAMPLE, ROMAN CEMENT IS A COLLOID THAT IS STILL REVEALING THE MYSTERIES OF ITS DURABILITY AFTER TWO MILLENNIA. MODERN METHODS SUCH AS ADDITIVE MANUFACTURING AND SELF-ORGANIZATION OF PARTICLES ALLOW FOR THE FABRICATION OF COMPLEX MATERIALS WITH UNPRECEDENTED COMBINATIONS OF MECHANICAL, ELECTRICAL, BIOLOGICAL, AND CHEMICAL PROPERTIES. THE LACK OF A THEORETICAL FOUNDATION TO PREDICT THE PROPERTIES OF COLLOIDS AS DYNAMIC SYSTEM OF POLYDISPERSED PARTICLES FORMING COMPLEX STRUCTURES, HOWEVER, HINDERS DISCOVERY OF NOVEL MATERIALS CRITICAL FOR TECHNOLOGICAL PROGRESS. NEW IDEAS AND APPROACHES ARE THEREFORE NEEDED TO CORRELATE FUNCTIONALITY WITH STRUCTURAL COMPLEXITY. THE CENTER FOR COMPLEX PARTICLE SYSTEMS (COMPASS) BRINGS TOGETHER A TEAM OF THEORETICAL, EXPERIMENTAL, AND COMPUTATIONAL RESEARCHERS TO DEVELOP THE SCIENCE AND TECHNOLOGY NECESSARY TO ESTABLISH A SYSTEMS-LEVEL APPROACH FOR PARTICLE-BASED MATTER. THE CENTER WILL INTEGRATE DIVERSE TECHNIQUES SUCH AS GRAPH THEORY AND MACHINE LEARNING WITH ADVANCED MICROSCOPY. THROUGH A FOCUS ON ?IMPERFECT? SYSTEMS, COMPASS AIMS TO IGNITE A REVOLUTION IN 3D PRINTING AND OTHER FORMS OF ADDITIVE MANUFACTURING WITH DIVERSE PARTICLE SYSTEMS. THE TRANSFORMATIVE IMPACT OF COMPASS WILL BE AMPLIFIED BY THRUSTS FOCUSED ON EDUCATIONAL, OUTREACH, AND ENTREPRENEURSHIP ACTIVITIES THAT PROVIDE OPPORTUNITIES FOR DISADVANTAGED HIGH SCHOOL STUDENTS, MINORITIES AND VETERANS. TECHNICAL DESCRIPTION: COMPASS REPRESENTS AN INTEGRATIVE EFFORT OF ADDRESSING THE KNOWLEDGE GAP OF HIERARCHICAL STRUCTURED MATERIALS BY BECOMING A COLLABORATIVE HOME FOR THEORETICAL, EXPERIMENTAL, AND COMPUTATIONAL RESEARCHERS WHO WILL TOGETHER DEVELOP THE SCIENCE AND TECHNOLOGY OF A SYSTEMS-LEVEL APPROACH FOR PARTICLE-BASED MATTER. THIS APPROACH TAKES ADVANTAGE OF TOOLS FROM THE FIELD OF DISCRETE MATHEMATICS KNOWN AS GRAPH THEORY AND NETWORK THEORY THAT HAS BEEN ADVANCED IN THE PAST PREDOMINANTLY FOR APPLICATION TO SOCIAL, ECONOMIC, OR NETWORKS-RELATED DISCIPLINES. COMPASS WILL ENABLE GRAPH AND NETWORK THEORIES TO PREDICT AND CONTROL THE COMPLEX BEHAVIOR OF STRONGLY INTERACTING COLLOIDAL PARTICLES CAPABLE OF SPONTANEOUSLY PRODUCING STATIC AND DYNAMIC NETWORKS AND MULTISCALE HIERARCHICAL STRUCTURES WITH HIGH COMPLEXITY. THE CROSS-POLLINATION AMONG MATHEMATICS, PHYSICAL SCIENCES AND ENGINEERING DISCIPLINES DESCRIBING PARTICLE-BASED MATTER AS A COMPLEX SYSTEM OF NON-IDEAL PARTICLES WILL ENABLE A PARADIGMATIC SHIFT IN THE ENDURING PROBLEMS ASSOCIATED WITH SHAPING MATTER. THE ACTIVITIES OF THE CENTER SPAN FROM THE DEVELOPMENT OF FOUNDATIONAL METHODS TO TECHNOLOGY-ENABLING APPLICATIONS AND ARE ORGANIZED IN FOUR RESEARCH-RELATED THRUSTS. THRUST #1, GRAPH THEORETICAL DESCRIPTION OF COLLOIDS AS COMPLEX SYSTEMS, FOCUSES ON THE METHODOLOGY FOR A GRAPH-BASED DESCRIPTION OF ENSEMBLES OF PARTICLES WITH COMPLEX SHAPES AND SPATIOTEMPORAL ARRANGEMENTS FOR THEIR SUBSEQUENT USE. THRUST #2, GRAPH-BASED FUNCTIONALITY METRICS FOR COLLOIDAL PARTICLE SYSTEMS, ESTABLISHES RELATIONSHIPS BETWEEN GRAPH REPRESENTATIONS OF THE STRUCTURE OF COLLOIDAL SYSTEMS AND THEIR MECHANICAL, ELECTRICAL, AND CHEMICAL PROPERTIES. PREDICTIONS WILL BE VALIDATED USING EXPERIMENTAL AND COMPUTATIONAL TECHNIQUES WITH MODEL PARTICLE SYSTEMS AT MACRO-, MICRO- AND NANOSCALES. THRUST #3, PATHWAYS TO COMPLEX PARTICLE SYSTEMS, DEVELOPS PATHWAYS TO COMPLEX PARTICLE SYSTEMS BY TAKING ADVANTAGE OF EMERGENCE, SELF-ASSEMBLY, AND CRITICALITY PHENOMENA IN ?COMMUNITIES? OF STRONGLY INTERACTING POLYDISPERSE PARTICLES. ADVANCES IN PREVIOUS THRUSTS COME TOGETHER IN THRUST #4, IMPLEMENTATION OF COMPLEX PARTICLE SYSTEMS. THIS THRUST TRANSLATES THE CUMULATIVE KNOWLEDGE ACQUIRED IN THE PRECEDING TASKS TO CASE STUDIES OF COMPLEX PARTICLE SYSTEMS THAT TRANSPORT PHYSICAL QUANTITIES DIRECTLY RELATED TO THE DYNAMIC CONNECTIVITY OF DIVERSE READILY ACCESSIBLE PARTICLES SUITABLE FOR ADDITIVE MANUFACTURING. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE PLANNED FOR THIS AWARD.

TAS::89 0321::TAS AWARD TO THE REGENTS OF THE UNIVERSITY OF MICHIGAN FOR THE FOA DE-FOA-0000324 ENTITLED U.S. CHINA CLEAN ENERGY RESEARCH CENTER C

NEW ARC VI COOPERATIVE AGREEMENT WITH UOFM WITH THE BASIC AND APPLIED RESEARCH THAT ADVANCES THE STATE-OF-THE-ART IN HIGH FIDELITY MODELING, SIMULATION, AND TESTING OF MILITARY GROUND VEHICLES AND PROVIDE LINKAGES BETWEEN AUTOMOTIVE SUPPLIERS, MANUFACTURERS, AND THE MILITARY IN THE CRITICAL PRODUCT DEVELOPMENT PHASE.

CILER 5-YEAR RENEWAL PROPOSAL - JULY 1, 2012 THROUGH JUNE 30, 2017.

MID-SCALE RI-1 (M1:IP): ZETTAWATT-EQUIVALENT ULTRASHORT PULSE LASER SYSTEM (ZEUS)

CONTINUITY AND CHANGE IN AMERICAN ECONOMIC AND SOCIAL LIFE: THE PSID 2012-2016

NSF I-CORPS HUB: GREAT LAKES REGION

UNIVERSITY TRANSPORTATION CENTERS

MICHIGAN CENTER ON THE DEMOGRAPHY OF AGING

HEALTH, CAREGIVING, COGNITION, AND WELL-BEING OVER THE LIFE COURSE AND ACROSS MULTIPLE GENERATIONS - PROJECT SUMMARY THIS APPLICATION PROPOSES TO COLLECT, PROCESS, AND DISSEMINATE DATA IN THE 2025 AND 2027 WAVES OF THE PANEL STUDY OF INCOME DYNAMICS (PSID), INCLUDING A NEW SUPPLEMENT ON CAREGIVING AND COGNITION IN 2026, WHICH WILL ENHANCE INFORMATION ON COGNITIVE PRECURSORS TO AND CAREGIVING FOR ALZHEIMER’S DISEASE AND RELATED DEMENTIAS (ADRD). THE PSID IS A LONGITUDINAL SURVEY OF A NATIONALLY REPRESENTATIVE SAMPLE OF U.S. FAMILIES THAT WAS BEGUN IN 1968. A CORNERSTONE OF THE NATION’S SOCIAL SCIENCE RESEARCH INFRASTRUCTURE, PSID HAS COLLECTED 43 WAVES OF DATA OVER 56 YEARS ON ORIGINAL FAMILIES AND THEIR DESCENDANTS. ITS LONG-TERM MEASURES OF ECONOMIC AND SOCIAL WELLBEING ALLOW STUDY OF THE DYNAMICS OF SOCIAL AND BEHAVIORAL PROCESSES AND HOW THEY INTERACT WITH HEALTH OVER THE LIFE COURSE. ITS DESIGN OF FOLLOWING CHILDREN OF SAMPLE MEMBERS WHEN THEY BECOME ECONOMICALLY INDEPENDENT SUPPORTS STUDY OF THE INTERGENERATIONAL TRANSMISSION OF SOCIOECONOMIC CIRCUMSTANCES AND HEALTH. NEARLY 7,400 PUBLICATIONS OVER ITS 50-PLUS YEAR HISTORY ATTEST TO THE PSID’S BROAD SCIENTIFIC REACH. THIS PROJECT WILL COLLECT, PROCESS, AND DISTRIBUTE DATA ON HEALTH, WEALTH, AND TIME USE FOR MORE THAN 11,000 FAMILIES IN PSID’S 2025 AND 2027 WAVES, COLLECT SALIVA SAMPLES TO SUPPORT MULTI-GENERATIONAL GENOMIC ANALYSIS, AND EXPAND MULTI- GENERATIONAL DATA ON CAREGIVING AND COGNITIVE PRECURSORS TO ADRD. SPECIFICALLY, THE PROJECT WILL: 1. COLLECT HEALTH, WEALTH AND TIME USE DATA IN THE CORE PSID 2025 AND 2027 WAVES, INCLUDING NEW ITEMS TO IDENTIFY UNPAID CAREGIVERS, WHETHER CARE IS PROVIDED FOR ADRD, AND TO WHOM CARE IS PROVIDED. 2. COLLECT AND STORE SALIVA SAMPLES FROM ADULTS IN PSID 2025 TO OBTAIN DNA FROM THREE GENERATIONS OF THE SAME FAMILIES. 3. COLLECT A WEB SUPPLEMENT FOR BOTH REFERENCE PERSONS AND SPOUSE/PARTNERS IN 2026 ON CAREGIVING AND COGNITION, TO INCLUDE: MEASURES OF EVERYDAY COGNITION (QUANTITATIVE AND VERBAL REASONING; FINANCIAL AND HEALTH LITERACY); FAMILY ROSTERS; INTERGENERATIONAL TRANSFERS OF TIME AND MONEY ACROSS PARENTS AND CHILDREN; AND CAREGIVING EXPECTATIONS (EXPECTATIONS FOR RECEIVING CARE AND PROVIDING IT). 4. PROCESS AND DISTRIBUTE CORE AND SUPPLEMENTAL FILES; CREATE LIFE COURSE AND FAMILY CONTEXT FILES; UPDATE AND EXPAND THE NEW PSID SOCIAL, HEALTH, AND ECONOMIC LONGITUDINAL FILE (SHELF) AND FILES ON FAMILY RELATIONSHIPS AND COMPLEXITY; MAKE PARADATA PUBLICLY AVAILABLE (INCLUDING MEASURES SHOWN TO BE PRECURSORS TO ADRD); AND PROVIDE USER SUPPORT AND TRAINING. AFTER COLLECTION, SURVEY DATA WILL BE PROCESSED AND DISTRIBUTED VIA PSID’S ONLINE DATA CENTER, WHICH ALLOWS USERS TO CREATE CUSTOMIZED EXTRACTS AND CODEBOOKS. SENSITIVE DATA WILL BE MADE AVAILABLE TO QUALIFIED USERS UNDER CONTRACT WITH THE UNIVERSITY OF MICHIGAN. SALIVA SAMPLES WILL BE STORED FOR GENOTYPING IN THE ISR BIOSPECIMEN LAB. TAKEN TOGETHER, THIS PROJECT WILL EXPAND THE POTENTIAL OF PSID AS A RESOURCE FOR EXAMINING HEALTH, WEALTH, TIME USE, CAREGIVING AND ADRD OVER TIME AND WITHIN AND ACROSS FAMILIES.

ECONOMICS STATUS, HEALTH, & WELL-BEING OVER THE LIFE COURSE AND ACROSS GENERATION

CARES ACT- EMERGENCY FINANCIAL AID GRANTS TO STUDENTS- FLINT

THE CENTER FOR HIV RNA STUDIES (CRNA)

UNIVERSITY OF MICHIGAN INSTITUTE FOR SOCIAL RESEARCH EXPANSION

SPECIAL PROGRAMS (SP)

MULTIDISCIPLINARY TRAINING PROGRAM IN LUNG DISEASE

GASTROINTESTINAL HORMONE RESEARCH CORE CENTER

CELLULAR DECISIONS OF DIFFERENTIATION IN THE GI TRACT

THE 2024 AMERICAN NATIONAL ELECTION STUDIES (ANES) -THE 2024 AMERICAN NATIONAL ELECTION STUDY (ANES) WILL OCCUR AT A MOMENT OF GREAT UNCERTAINTY AND CHANGE IN AMERICAN POLITICS. THE PUBLIC IS DIVIDED OVER LONG-STANDING POLITICAL NORMS INVOLVING EXECUTIVE POWER, ELECTORAL LEGITIMACY, THE RULE OF LAW, AND SOCIETAL NORMS SUCH AS THE PROPER BALANCE OF PUBLIC HEALTH CONCERNS WITH INDIVIDUAL FREEDOMS. SINCE 1948, THE ANES HAS BEEN THE GOLD STANDARD FOR MEASURING PUBLIC OPINION AND UNDERSTANDING VOTING BEHAVIOR IN THE UNITED STATES. THE 2024 ANES MAINTAINS THE TRADITION OF A NONPARTISAN, SCIENTIFICALLY VALID SURVEY WHILE ADDING CUTTING-EDGE INNOVATIONS. NEW AND EXISTING QUESTIONS ON THE ANES SURVEY ALLOW RESEARCHERS TO UNDERSTAND THE SOURCES OF POLITICAL DISCONTENT, EXPLAIN MISUNDERSTANDINGS BETWEEN ELECTED OFFICIALS THE PUBLIC, AND IDENTIFY OPPORTUNITIES FOR BRIDGING THE COUNTRY'S POLITICAL AND SOCIAL DIVISIONS. THE 2024 ANES CONTINUES THE ANES TRADITION OF ADMINISTERING BOTH PRE- AND POST-ELECTION INTERVIEWS, PRODUCING SEVERAL NEW DATA PRODUCTS INCLUDING THE FIRST-EVER EIGHT-YEAR PANEL IN THE ANES TIME SERIES, SPANNING THE 2016, 2020, AND 2024 ELECTION CYCLES. THIS DATA SET ALLOWS RESEARCHERS TO BREAK FRESH GROUND ON TOPICS INCLUDING OPINION DYNAMICS DURING A PERIOD OF EXTREME VOLATILITY, THE SPREAD OF MISINFORMATION, SUPPORT FOR POLITICAL VIOLENCE, AFFECTIVE POLARIZATION, RACIAL CONFLICT, AND THREATS TO THE LEGITIMACY OF OUR ELECTORAL INSTITUTIONS. THE 2024 STUDY ALSO DELIVERS A SOCIAL MEDIA STUDY PANEL SPANNING 2020, 2022, AND 2024, PROVIDING DATA ON THE ELECTORAL CONSEQUENCES OF NEWS USE AND POLITICAL ADVERTISING ON SOCIAL MEDIA BY MERGING RESPONDENT ATTITUDES TO BEHAVIORAL DATA. ONGOING COLLABORATIONS WITH GENERAL SOCIAL SURVEY AND THE COMPARATIVE STUDY OF ELECTORAL SYSTEMS YIELD NEW DATASETS OF INTEREST TO SCHOLARS IN SOCIOLOGY, ECONOMICS, POLITICAL COMMUNICATION, COMPARATIVE POLITICS, AND INTERNATIONAL RELATIONS. METHODOLOGICAL INNOVATIONS INCLUDE A NON-RESPONSE FOLLOW-UP STUDY, NEW INSTRUMENTATION PROBING CRITICAL THREATS TO DEMOCRACY, VIDEO INTERVIEWING, AND THE USE OF A MIXED-MODE DESIGN TO YIELD FURTHER INSIGHTS ABOUT SURVEY MODE EFFECTS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

CEMRI FOR PHOTONIC AND MULTISCALE NANOMATERIALS

THE MOLECULAR BASIS OF HEAD AND NECK CANCER BIOLOGY, TREATMENT AND PREVENTION

MICHIGAN CENTER FOR INTEGRATIVE APPROACHES TO HEALTH DISPARITIES (CIAHD)

FAMILY DYNAMICS, FERTILITY, AND INVESTMENTS IN CHILDREN ACROSS GENERATIONS

STROKE SURVEILLANCE IN A BIETHNIC COMMUNITY

CILER - PROPOSAL FOR GREAT LAKES REGIONAL RESEARCH INSTITUTE

THE CHALLENGE OF INDIVIDUALIZING TREATMENTS FOR PATIENTS WITH BREAST CANCER

CENTER FOR METHODOLOGIES FOR ADAPTING AND PERSONALIZING PREVENTION, TREATMENT AND RECOVERY SERVICES FOR SUD AND HIV (MAPS CENTER) - PROJECT SUMMARY: OVERALL EFFECTIVE PREVENTION, TREATMENT, AND RECOVERY SERVICES FOR SUBSTANCE USE DISORDERS (SUD) AND HIV DEMAND AN INCREASING ARRAY OF EVIDENCE-BASED INTERVENTIONS TO ADDRESS INDIVIDUALS' CHANGING STRENGTHS, NEEDS, AND CIRCUMSTANCES. THIS CAN BE ACHIEVED VIA ADAPTIVE INTERVENTIONS, WHICH EXPLICITLY GUIDE HOW TO MODIFY THE TYPE/ INTENSITY OF SERVICES BASED ON INFORMATION ABOUT THE INDIVIDUAL. FURTHER, ADVANCES IN DIGITAL TECHNOLOGIES, SUCH AS ELECTRONIC HEALTH RECORDS (EHRS) AND MOBILE DEVICES, HAVE CREATED UNPRECEDENTED OPPORTUNITIES TO OBTAIN DATA FOR USE IN ADAPTING INTERVENTIONS TO DIFFERENT LEVELS (E.G., INDIVIDUAL, CLINIC, HEALTH SYSTEM), MODALITIES (E.G., DIGITAL, IN-PERSON), AND/OR TIME SCALES (E.G., MONTHLY, MANY TIMES A DAY). HOWEVER, NEW RESEARCH METHODOLOGIES ARE NEEDED TO REALIZE THESE OPPORTUNITIES AND INFORM A NEW GENERATION OF SUD/HIV SERVICES. THE FOCUS OF THE PROPOSED CENTER FOR METHODOLOGIES FOR ADAPTING AND PERSONALIZING PREVENTION, TREATMENT, AND RECOVERY SERVICES FOR SUD AND HIV (MAPS CENTER) IS THE DEVELOPMENT AND DISSEMINATION OF NOVEL RESEARCH METHODOLOGIES THAT ARE ESSENTIAL TO OPTIMIZE ADAPTIVE INTERVENTIONS TO COMBAT SUD/HIV. WE PROPOSE THREE EXCITING, THEMATICALLY INTEGRATED RESEARCH PROJECTS, EACH DEVELOPING NEW METHODS TO EMPIRICALLY INFORM THE CONSTRUCTION OF ADAPTIVE SUD/HIV SERVICES. TWO INNOVATIVE THEMES — OPTIMIZATION (I.E., DEVELOPING SERVICES THAT ACHIEVE THE BEST EXPECTED OUTCOME IN A WAY THAT IS NOT TOO EXPENSIVE, COMPLEX, OR DEMANDING TO BE SCALABLE) AND ADAPTATION (I.E., USING INFORMATION ABOUT CONTEXT AND CHANGING NEEDS TO DECIDE WHEN AND HOW TO INTERVENE) — CUT ACROSS THESE PROJECTS, ENABLING OUR TEAM TO MOVE SUD/HIV INTERVENTION SCIENCE FORWARD WHILE CREATING ENORMOUS POTENTIAL FOR SCIENTIFIC SYNERGY. ALONG WITH THE THREE PROJECTS, TWO CORES — DISSEMINATION & TRAINING CORE AND ADMINISTRATIVE CORE — WILL ENABLE THE MAPS CENTER TO SERVE AS A NATIONAL RESOURCE BY TRAINING SUD/HIV SCIENTISTS IN THE CRITICAL USE OF THE METHODS, RECRUITING SCIENTISTS TO WORK ON OPTIMIZING ADAPTIVE SUD/HIV SERVICES, AND MENTORING EARLY CAREER SCHOLARS. THE OVERALL SPECIFIC AIMS OF THE MAPS CENTER ARE: (AIM A) TO DEVELOP NOVEL EXPERIMENTAL AND DATA ANALYTIC METHODS TO OPTIMIZE THE ADAPTATION OF SUD/HIV SERVICES ACROSS DIFFERENT LEVELS (E.G., INDIVIDUAL, CLINIC), MODALITIES (E.G., IN-PERSON, DIGITAL), AND TIME SCALES (E.G., MONTHLY, DAILY); (AIM B) TO SERVE AS A NATIONAL RESOURCE BY PLACING THE INNOVATIVE METHODS DEVELOPED IN THE MAPS CENTER DIRECTLY INTO THE HANDS OF SUD/HIV SCIENTISTS; AND (AIM C) TO NURTURE AND BUILD CAPACITY AMONG SCIENTISTS TO DESIGN EXPERIMENTS AND ANALYZE DATA TO INFORM THE DEVELOPMENT OF ADAPTIVE SUD/HIV SERVICES. THE MAPS CENTER WILL PAVE THE WAY FOR A NEW GENERATION OF HIGHLY EFFECTIVE AND SCALABLE INTERVENTIONS THAT WILL REDUCE THE PREVALENCE AND INCIDENCE OF SUD AND HIV INFECTION.

REIMBURSEMENT OF TRAVEL AND SUBSISTENCE EXPENSES FOR LIVING ORGAN DONATION

INTEGRATED SYSTEMS BIOLOGY APPROACH TO DIABETIC MICROVASCULAR COMPLICATIONS

THE UNIVERSITY OF MICHIGAN GEORGE M O'BRIEN RENAL CORE CENTER

SWAN REPOSITORY

THAPCA TRIALS - SCIENTIFIC APPLICATION

TISSUE ENGINEERING AND REGENERATION

MICHIGAN CENTER FOR URBAN AFRICAN AMERICAN AGING

UNIVERSITY OF MICHIGAN RETIREMENT RESEARCH CENTER, PHASE III, FISCAL YEAR 12.

PROSPECTIVE COHORT STUDY OF CHRONIC RENAL INSUFFICIENCY

UNIVERSITY OF MICHIGAN BACPAC MECHANISTIC RESEARCH CENTER

SPORE IN PROSTATE CANCER

MULTI-SPECTRAL TARGETED IMAGING FOR EARLY DETECTION OF CANCER IN BARRETT'S ESOPHA

MAINTAIN, OPERATE, AND SUSTAIN THE ANN ARBOR TEST ENVIRONMENT

CARES ACT- EMERGENCY FINANCIAL AID GRANTS TO STUDENTS- FLINT

INSTITUTIONAL TRAINING GRANT IN GENOMIC SCIENCE

EPILEPSY MULTIPLATFORM VARIANT PREDICTION (EPIMVP)

PHASE III RCT OF THE EFFECTIVENESS OF SILVER DIAMINE FLUORIDE IN ARRESTING CAVITATED CARIES LESIONS

TRANSLATIONAL RESEARCH IN GI CANCER

CHOLINERGIC MECHANISMS OF ATTENTIONAL-MOTOR INTEGRATION AND GAIT DYSFUNCTION IN PARKINSON DISEASE - OVERALL COMPONENT: SUMMARY/ABSTRACT PROGRESSIVE GAIT-BALANCE DIFFICULTIES, ASSOCIATED FALLS, AND COGNITIVE IMPAIRMENTS ARE COMMON AND DISABLING DOPAMINE REPLACEMENT THERAPY (DRT)-RESISTANT FEATURES OF PARKINSON DISEASE (PD), AFFECTING NEARLY ALL PATIENTS. IN THE PRIOR CYCLE, U-M UDALL CENTER RESEARCH DEMONSTRATED PROMINENT, MULTIFACETED, AND DYNAMIC IMPACTS OF CHOLINERGIC SYSTEMS DEGENERATION IN PD GAIT AND COGNITIVE ABNORMALITIES. THESE INSIGHTS LED US TO A NOVEL APPROACH TO PD PATHOPHYSIOLOGY; A SYSTEMS NEUROSCIENCE MODEL OF DEFICIENT INTEGRATION OF ATTENTIONAL AND MOTOR FUNCTIONS. THIS CONCEPT AND OUR PRIOR WORK POSITION US TO PURSUE INTEGRATED CLINICAL AND BASIC RESEARCH TESTING HYPOTHESES EMBODIED IN THIS MODEL OF ATTENTIONAL-MOTOR INTEGRATION (AMI) NETWORK DISRUPTION. OUR RESULTS SUGGEST THAT PATTERNS OF DISRUPTED CHOLINERGIC NEUROTRANSMISSION WITHIN MULTIPLE AMI NODES ARE RESPONSIBLE FOR CHARACTERISTIC PD GAIT AND BALANCE ABNORMALITIES, THAT STRIATAL CHOLINERGIC INTERNEURONS ARE CRUCIAL INTEGRATORS OF ATTENTIONAL AND MOTOR INFORMATION, AND THAT CHOLINERGIC DENERVATION OF KEY CORTICAL AMI NODES HAS GLOBAL COGNITIVE EFFECTS AND PREDICTS MORE RAPID DISEASE PROGRESSION. PROJECT I WILL EMPLOY THE CHOLINERGIC PET LIGAND [18F]FEOBV IN PD SUBJECTS TO PROSPECTIVELY TEST THE HYPOTHESIS THAT SPECIFIC REGIONAL PATTERNS OF CHOLINERGIC TERMINAL DEGENERATION ASSOCIATE WITH SPECIFIC PD GAIT-BALANCE ABNORMALITIES. PROJECT II WILL DISSECT, IN A RODENT MODEL, THE ROLE OF CHOLINERGIC NEUROTRANSMISSION IN DETECTING, TRANSFERRING, AND INTEGRATING ATTENTIONAL INFORMATION AS IT TRAVERSES CORTICAL AND STRIATAL CIRCUITS. OPTO- AND CHEMO-GENETIC STRATEGIES WILL BE USED TO TEST WHETHER MANIPULATING CORTICAL OR STRIATAL CHOLINERGIC NEUROTRANSMISSION AFFECTS FALL PROPENSITY IN THE “DUAL LESION” (DL) RODENT MODEL OF PD FALLS. PROJECT III WILL ASSESS IF EARLY ANTERIOR CINGULATE AND INSULAR CHOLINERGIC DENERVATION HAS GLOBAL EFFECTS ON COGNITION AND IS A PREDICTOR OF MORE RAPID COGNITIVE DECLINE. PROJECTS I AND III TAKE ADVANTAGE OF UNIQUE PROSPECTIVELY FOLLOWED PD SUBJECT COHORTS. THE CATALYST RESEARCH PROJECT WILL STUDY CELLULAR MECHANISMS OF CHOLINERGIC SIGNALING AND ITS ROLE IN VISUAL ATTENTION IN A KEY AMI NODE, THE RETROSPLENIAL CORTEX. U-M UDALL CENTER PROJECTS ARE SUPPORTED BY ADMINISTRATIVE, CLINICAL RESOURCE, NEUROIMAGING RESOURCE AND BIOSTATISTICS AND DATA MANAGEMENT CORES. WE WILL COLLABORATE WITH MEMBERS OF THE PACIFIC AND UNIVERSITY OF ROCHESTER UDALL CENTERS. THE ADMINISTRATIVE CORE WILL OVERSEE MENTORSHIP OF EARLY STAGE INVESTIGATORS, INCLUDING A UDALL RESEARCH FELLOW AND THE CATALYST RESEARCH PROJECT LEAD. THE ADMINISTRATIVE CORE WILL DIRECT OUTREACH TO THE PD COMMUNITY. OUR INNOVATIVE APPROACHES WILL ADVANCE THE GOAL OF THE NINDS UDALL CENTERS OF EXCELLENCE PROGRAM TO “DEFINE THE CAUSES OF AND DISCOVER IMPROVED TREATMENTS FOR PD.” NO OTHER UDALL CENTER IS FOCUSED ON GAIT AND POSTURAL ABNORMALITIES IN PD, ON INTEGRATION OF COGNITIVE AND MOTOR FUNCTIONS, ON CHOLINERGIC DEFICITS, OR ON USE OF A PATHOLOGICAL PREDICTOR TO DEFINE PD SUBGROUPS. THE PROPOSED U-M UDALL CENTER WILL CONTINUE TO PLAY A UNIQUE AND IMPORTANT ROLE WITHIN THE UDALL CENTERS PROGRAM.

SPACE POWER AND PROPULSION FOR AGILITY, RESPONSIVENESS, AND RESILIENCE (SPAR)

IDENTIFYING GENES FOR TYPE 2 DIABETES: FUSION

CORE CENTER FOR VISION RESEARCH

THE VIRTUAL PHYSIOLOGICAL RAT PROJECT

NA-121 - CENTER FOR RADIATIVE SHOCK HYDRODYNAMICES (CRASH)

MICHIGAN MOTRPAC CHEMICAL ANALYSIS SITE (MICAS)

HOST AND MICROBIAL METABOLISM IN GRAFT VERSUS HOST DISEASE

MICHIGAN-PITTSBURGH-WYSS RESOURCE CENTER: SUPPORTING REGENERATIVE MEDICINE IN DENTAL, ORAL AND CRANIOFACIAL TECHNOLOGIES

TRANSITION FROM ACUTE TO CHRONIC PAIN AFTER THORACIC SURGERY

MICHIGAN-PUBLIC HEALTH INTEGRATED CENTER FOR OUTBREAK ANALYTICS AND MODELING

TRAINING IN THE DEMOGRAPHY AND ECONOMICS OF AGING

PSID 2025: CONTINUITY AND CHANGE IN AMERICAN ECONOMIC AND SOCIAL LIFE -THE PANEL STUDY OF INCOME DYNAMICS (PSID) IS A CORNERSTONE OF DATA INFRASTRUCTURE FOR SOCIAL SCIENCE RESEARCH IN THE UNITED STATES. THE STUDY HAS USED A SERIES OF SURVEYS TO GATHER INFORMATION ON US FAMILIES SINCE 1968. CHILDREN AND GRANDCHILDREN FROM THE ORIGINAL PSID FAMILIES NOW PARTICIPATE AS WELL; THE RESULT IS DATA THAT FOLLOWS FAMILIES THROUGH SEVERAL GENERATIONS. THE LONG TIMESPAN ALLOWS SCIENTIFIC INVESTIGATION OF QUESTIONS ABOUT HOW PEOPLE AND FAMILIES GROW AND CHANGE OVER TIME. THIS INCLUDES THE STUDY OF ECONOMIC OUTCOMES SUCH AS EMPLOYMENT, INCOME, AND WEALTH, RESEARCH ON HOW EARLY LIFE EXPERIENCES AFFECT EMPLOYMENT AND HEALTH IN ADULTHOOD, RESEARCH ON HOW U.S. FAMILIES COPE WITH THE NEEDS OF AGING FAMILY MEMBERS, AND WORK THAT EXAMINES HOW KEY ECONOMIC VARIABLES LIKE CONSUMPTION AND EMPLOYMENT ARE AFFECTED BY BROADER BUSINESSES CYCLES AND UNANTICIPATED EVENTS. THE RESEARCH TEAM WILL COLLECT ONE NEW WAVE OF DATA. THE NEW WAVE WILL INCLUDE MEASUREMENTS OF THE LONGER RUN EFFECT OF THE COVID-19 PANDEMIC ON PSID FAMILIES. THIS INCLUDES MEASUREMENTS OF THE DIRECT HEALTH IMPACTS OF THE DISEASE, THE EFFECTS OF DISRUPTIONS TO EMPLOYMENT AND EDUCATION, AND WHETHER FAMILY MEMBERS WERE HELPED BY GOVERNMENT EFFORTS TO REDUCE THE BURDEN OF THE PANDEMIC. THE PIS ALSO PLAN NEW MEASUREMENTS OF PARTICIPATION IN SHORT TERM ?GIG ECONOMY? JOBS, WILL EXPAND VALUABLE ADMINISTRATIVE DATA LINKAGES, AND WILL CONTINUE THEIR CURRENT EFFORT TO EXPAND WEB-BASED ADMINISTRATION OF THE PSID QUESTIONNAIRE. THE PROJECT PROMOTES THE NATIONAL INTEREST BY MAINTAINING U.S. LEADERSHIP IN SCIENCE, BY MAKING DATA AVAILABLE TO A BROAD COMMUNITY OF RESEARCHERS INTERESTED IN UNDERSTANDING AMERICAN FAMILIES, AND BY PROVIDING NECESSARY DATA TO EVALUATE THE LONG-TERM IMPACTS OF PAST POLICY DECISIONS AT THE FEDERAL, STATE, AND LOCAL LEVELS OF GOVERNMENT. THE PSID IS THE WORLD'S LONGEST RUNNING HOUSEHOLD PANEL SURVEY. THROUGH ITS LONG-TERM MEASURES OF ECONOMIC AND SOCIAL WELLBEING, THE STUDY ALLOWS RESEARCHERS AND POLICY ANALYSTS TO INVESTIGATE THE DYNAMISM INHERENT IN SOCIAL AND BEHAVIORAL PROCESS. THE LONG PANEL, GENEALOGICAL DESIGN, AND BROAD CONTENT PROVIDE SCIENTISTS A UNIQUE AND POWERFUL OPPORTUNITY TO STUDY CHANGE WITHIN THE SAME FAMILY OVER DECADES. COLLECTING ADDITIONAL WAVES OF DATA FROM THE PSID FAMILIES CONTRIBUTES TO SCIENTIFIC UNDERSTANDING OF THE DYNAMICS OF ECONOMIC AND SOCIAL BEHAVIOR. THE EXTENDED TIME SERIES OF DATA SUPPORTS NEW AND SYSTEMATIC INVESTIGATION OF A MYRIAD OF QUESTIONS IN THE FULL RANGE OF SCIENTIFIC DISCIPLINES THAT STUDY HOW HUMANS GROW AND CHANGE OVER THE LIFE CYCLE. THIS INCLUDES THE STUDY OF ECONOMIC OUTCOMES (FOR EXAMPLE, THE CHANGES THAT OCCUR ACROSS BUSINESS CYCLES AND CHANGES IN RESPONSE TO INCREASED INTERNATIONAL ECONOMIC COMPETITION), THE STUDY OF INTERGENERATIONAL TRANSMISSION OF WEALTH AND INCOME, AND THE STUDY OF HOW INCOME AND HEALTH IN ADULTHOOD AND OLD AGE DEPEND ON EARLY-LIFE EXPERIENCES. CONSISTENT MEASURES OVER TIME ARE IMPORTANT FOR ACCURATELY ESTIMATING THE DYNAMICS OF THESE BEHAVIORS. GATHERING DATA FROM THE SAME FAMILIES OVER MANY YEARS IMPROVES THE PRECISION OF THE MEASUREMENT AS MULTIPLE MEASURES ARE COLLECTED WITHIN THE SAME FAMILIES AS WELL AS FROM MULTIPLE FAMILIES OVER A PERIOD OF DECADES. THE INVESTIGATORS WILL CARRY OUT NUMEROUS INNOVATIONS AND ENHANCEMENTS WHILE MAINTAINING CORE DATA COLLECTION FOR COMPARABILITY. THE PSID CREATES BROADER IMPACTS IN MANY WAYS. IT IS USED BY AN INTERDISCIPLINARY COMMUNITY AND IS INCREASINGLY IMPORTANT IN HEALTH RESEARCH. THE DATA ARCHIVE IS USED TO INFORM PUBLIC POLICY; AT LEAST NINE FEDERAL AGENCIES USE PSID DATA. THE PSID IS ALSO AN IMPORTANT RESOURCE FOR TEACHING AND LEARNING. THE DATA ARE FREE AND PUBLICLY AVAILABLE. THEY ARE WIDELY USED BY GRADUATE AND UNDERGRADUATE STUDENTS. THE AWARD FUNDS WEB-BASED OUTREACH ACTIVITIES THAT WILL MAKE THE PSID AN EVEN MORE VALUABLE TOOL FOR TEACHING AND LEARNING. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

SOCIAL SCIENCE TRAINING IN POPULATION STUDIES

MICHIGAN DIABETES RESEARCH AND TRAINING CENTER

CUREGN

EMERGENCY DEPARTMENT SCREEN FOR TEENS AT RISK FOR SUICIDE (ED-STARS)

STUDIES OF RARE GENETIC VARIATION IN THE ISOLATED POPULATION OF SARDINIA

MECHANO-CHEMICAL UNDERSTANDING OF SOLID ION CONDUCTORS (MUSIC)

PELVIC FLOOR DISORDERS NETWORK-DATA COORDINATING CENTER

NATION CENTER- INTEGRATIVE BIOMEDICAL INFORMATICS(RMI)

THE CENTER FOR HIV RNA STUDIES (CRNA)

BIRTH, MUSCLE INJURY AND PELVIC FLOOR DYSFUNCTION

MICHIGAN ALZHEIMER'S DISEASE CORE CENTER

CHOLINERGIC MECHANISMS OF GAIT DYSFUNCTION IN PARKINSON'S DISEASE

MICHIGAN REGIONAL COMPREHENSIVE METABOLOMICS RESOURCE CORE (MRC2)

TRENDS AND DYNAMICS IN CAREGIVING FOR ALZHEIMER?S DISEASE AND RELATED DEMENTIAS: EXTENDING THE NATIONAL STUDY OF CAREGIVING

MOLECULAR GENETICS OF COAGULATION DISORDERS

SMART INTERSECTIONS PAVING THE WAY FOR A NATIONAL CAV DEPLOYMENT

AACE 2.0 THE ANN ARBOR CONNECTED ENVIRONMENT REIMAGINED

MICHIGAN RETIREMENT AND DISABILITY RESEARCH CENTER

SYSTEMS BIOLOGY OF CLOSTRIDIUM DIFFICILE INFECTION

UNIVERSITY OF MICHIGAN MAPP RESEARCH NETWORK DISCOVERY SITE

THE STEWARDSHIP SCIENCE ACADEMIC ALLIANCES (SSAA) PROGRAM WAS ESTABLISHED IN 2002 TO SUPPORT STATE-OF-THE-ART RESEARCH AT U.S. ACADEMIC INSTITUTIONS IN AREAS OF FUNDAMENTAL PHYSICAL SCIENCE AND TECHNOLOGY OF RELEVANCE TO THE SSP MISSION. THE SSAA PROGRAM PROVIDES THE RESEARCH EXPERIENCE NECESSARY TO MAINTAIN A CADRE OF TRAINED SCIENTISTS AT U.S. UNIVERSITIES TO MEET THE NATION’S CURRENT AND FUTURE SSP NEEDS, WITH A FOCUS ON THOSE AREAS NOT SUPPORTED BY OTHER FEDERAL AGENCIES. IT SUPPORTS THE DOE/NNSA’S PRIORITIES BOTH TO ADDRESS THE WORKFORCE SPECIFIC NEEDS IN SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS AND TO SUPPORT THE NEXT GENERATION OF PROFESSIONALS WHO WILL MEET THOSE NEEDS.ONLY APPLICATIONS FOR COOPERATIVE AGREEMENTS AWARDS WILL BE ACCEPTED FOR THIS SOLICITATION, NO GRANT APPLICATIONS WILL BE CONSIDERED. THE SPECIFIC AREAS OF INTEREST ARE: 1. ADVANCED CHARACTERIZATION OF MATERIALS PROPERTIES UNDER EXTREME CONDITIONS 2. LOW ENERGY NUCLEAR SCIENCE 3. RADIOCHEMISTRY 4. HIGH ENERGY DENSITY PHYSICS

GENOMIC APPROACHES TO COMMON CHRONIC DISEASE

US INFLUENZA VACCINE EFFECTIVENESS NETWORK

STUDY OF WOMEN'S HEALTH ACROSS THE NATION-ENDOCRINE LAB

RACIAL/ETHNIC DISPARITIES IN ADRD RISK: THE IMPACT OF SOCIAL RELATIONS

M-CHEAR: MICHIGAN CHILDREN'S HEALTH EXPOSURE ANALYSIS RESOURCE LABORATORY HUB

CENTER OF EXCELLENCE IN NANO MECHANICAL SCIENCE & ENGINEERING (NAMSE)

UNIVERSITY OF MICHIGAN (UM) HEAL INITIATIVE NATIONAL K12 CLINICAL PAIN CAREER DEVELOPMENT PROGRAM (UM-HCPDP) - PROJECT SUMMARY / ABSTRACT THE OVERALL GOAL OF THE UNIVERSITY OF MICHIGAN (UM) HEAL NATIONAL K12 CLINICAL PAIN CAREER DEVELOPMENT PROGRAM (UM-HCPDP) IS TO DEVELOP A NATIONAL TRAINING PROGRAM FOR EARLY CAREER CLINICIAN-SCIENTISTS TO GROW THE NEXT GENERATION OF CLINICAL PAIN RESEARCHERS. THE UM-HCPDP IS HOUSED WITHIN THE CHRONIC PAIN AND FATIGUE RESEARCH CENTER, A UNIT WITHIN THE DEPARTMENT OF ANESTHESIOLOGY AT THE UM. THE CENTER POSSESSES A MULTIDISCIPLINARY AND COLLEGIAL CULTURE WITH EXTENSIVE DIDACTIC OPPORTUNITIES RELATED TO PAIN AND RESEARCH METHODS, ACCESS TO A DIVERSE GROUP OF PATIENT PARTNERS, AND THE EXPERTISE OF FACULTY COLLEAGUES LOCALLY, NATIONALLY, AND INTERNATIONALLY. THE UM-HCPDP PROVIDES ADMINISTRATIVE FUNCTIONS FOR THE NATIONAL K12 PROGRAM SUCH AS SELECTION OF SCHOLARS, DEVELOPMENT AND IMPLEMENTATION OF NATIONAL GUIDELINES FOR CAREER DEVELOPMENT AND MENTORING, AS WELL AS METHODS TO EVALUATE CAREER PROGRESS. ADMINISTRATIVE FUNCTIONS ALSO INCLUDE COORDINATION OF THE SCHOLARS' EXPERIENCE WHICH INCLUDES MENTORING AT THE SCHOLAR'S HOME INSTITUTION, MENTORING BY THE UM-HCPDP K12 ADVISORY COMMITTEE (I.E., SCIENTIFIC AND PATIENT MENTORS), ACCESS TO PAIN-SPECIFIC AND GENERAL DIDACTICS, AND LINKAGES TO THE COORDINATING CENTER FOR NATIONAL PAIN SCIENTISTS PROGRAM (CCNPS). THE UM-HCPDP ALSO OFFERS UNIQUE REMOTE ACCESS TO LOCALLY PRODUCED DIDACTICS IN PAIN, GENERAL SCIENTIFIC METHODS (E.G., ETHICS, RIGOR) AND SOFT SKILLS (E.G., LEADERSHIP AND JOB NEGOTIATION), AS WELL AS IN-PERSON ACCESS TO SUMMER SHORT COURSES (E.G., PAIN, EPIDEMIOLOGY, DATA SCIENCE). THREE SCHOLARS PER YEAR WILL BE SELECTED IN EACH OF THE 5 YEARS AND APPOINTED TO UP TO 3 YEARS OF TRAINING. ELIGIBLE APPLICANTS WILL BE IN THEIR LAST YEAR OF RESIDENCY, FELLOWSHIP, OR POST-DOCTORAL TRAINING AND/OR WITHIN 1 YEAR OF STARTING A FACULTY POSITION. ALL CANDIDATES MUST BE HOUSED AT AN EDUCATIONAL OR PROFESSIONAL ORGANIZATION IN THE U.S. THAT WILL COMMIT TO 75% PROTECTED TRAINING/RESEARCH TIME. ADDITIONALLY ALL CANDIDATES MUST BE COMMITTED TO CAREERS IN CLINICAL PAIN RESEARCH WITH THE GOAL OF PROFESSIONAL INDEPENDENCE AT THE CONCLUSION OF THE TRAINING PROGRAM. THE UM-HCPDP SEEKS TO CONTINUALLY IMPROVE THE NATION'S ABILITY TO TRAIN CLINICIAN-SCIENTISTS WITH A DEEP UNDERSTANDING OF PAIN MECHANISMS, NON-OPIOID TREATMENT OPTIONS, SCIENTIFIC METHODOLOGICAL RIGOR, LEADERSHIP, PATIENT-CENTRIC PERSPECTIVES, AND COMPASSION FOR THOSE WHO ARE SUFFERING. IMPACT: THE UM-HCPDP SEEKS TO CONTINUALLY IMPROVE THE NATION'S ABILITY TO TRAIN CLINICIANS AND SCIENTISTS WITH A DEEP UNDERSTANDING OF PAIN MECHANISMS, NON-OPIOID TREATMENT OPTIONS, SCIENTIFIC METHODOLOGICAL RIGOR, PATIENT-CENTRIC PERSPECTIVES, AND COMPASSION FOR THOSE WHO ARE SUFFERING.

UNIVERSITY OF MICHIGAN MULTI-DISCIPLINARY COORDINATING CENTER FOR THE COMMUNITY FIREARM INJURY PREVENTION NETWORK - FIREARM INJURY IS A MAJOR U.S. PUBLIC HEALTH CRISIS REQUIRING URGENT ATTENTION. FIREARM INJURIES HAVE INCREASED IN THE PAST DECADE, WITH >400,000 FATALITIES AND ~1.2 MILLION NON-FATAL FIREARM INJURIES. DISPARITIES EXIST AND ARE REFLECTIVE OF UNDERLYING STRUCTURAL FACTORS (E.G., RACISM). NATIONAL ORGANIZATIONS HIGHLIGHT THE NEED FOR EVIDENCE-BASED INTERVENTIONS; YET, FEW RIGOROUSLY TESTED COMMUNITY-ENGAGED INTERVENTIONS ADDRESSING FIREARM VIOLENCE EXIST, WITH EVEN FEWER ADDRESSING STRUCTURAL FACTORS UNDERLYING DISPARITIES. RECOGNIZING THIS GAP, NIH LAUNCHED THE COMMUNITY INTERVENTIONS FOR FIREARM VIOLENCE PREVENTION INITIATIVE. TEN RESEARCH PROJECTS, A STEERING COMMITTEE, A STAKEHOLDER COMMITTEE, AND THE NIH WILL COLLABORATE IN A COHESIVE NETWORK TO EVALUATE EFFICACY OF SUCH INTERVENTIONS ACROSS DIVERSE SETTINGS AND POPULATIONS WITH LEADERSHIP FROM A COORDINATING CENTER TO: (A) INTEGRATE KEY ACTIVITIES; (B) HARMONIZE AND LINK DATA ACROSS THE NETWORK, AS WELL AS TO PUBLIC DATABASES TO ACHIEVE SUFFICIENT STATISTICAL POWER TO CONDUCT INTEGRATED ANALYSES AND EXAMINE KEY DIFFERENCES AMONG SUB-POPULATIONS AND/OR SETTINGS; (C) ENHANCE MULTI-DISCIPLINARY COLLABORATION AND KNOWLEDGE SHARING ACROSS KEY AREAS (E.G., METHODOLOGY; ANALYTIC STRATEGIES; IMPLEMENTATION; ECONOMIC/POLICY ANALYSIS); AND, (D) AUGMENT DISSEMINATION. IN 2017, NICHD FUNDED THE UNIVERSITY OF MICHIGAN (UM) FACTS CONSORTIUM TO BRING TOGETHER >30 RESEARCHERS ACROSS 14 U.S. UNIVERSITIES TO BUILD PEDIATRIC FIREARM RESEARCH CAPACITY. ALONG WITH DEVELOPING A RESEARCH AGENDA AND NOVEL RESEARCH, FACTS BUILT THE DATA INFRASTRUCTURE NECESSARY TO CONDUCT COMPLEX POOLED ANALYSES AND ARCHIVE/STORE DATA IN A PUBLIC REPOSITORY. BUILDING ON THE FACTS CONSORTIUM AND OUR EXPERIENCE LEADING MULTIPLE CENTERS, THE UM ESTABLISHED THE INSTITUTE FOR FIREARM INJURY PREVENTION (IFIP) TO EXPAND THIS RESEARCH ACROSS THE BROADER SPECTRUM OF FIREARM INJURIES. WE PROPOSE FOR THE UM IFIP TO SERVE AS THE NETWORK COORDINATING CENTER FOR THIS INITIATIVE WITH FIVE AIMS: AIM #1: PROVIDE CENTRALIZED ADMINISTRATIVE, OPERATIONAL, AND LOGISTICAL INFRASTRUCTURE TO SUPPORT NETWORK ACTIVITIES AND ENHANCE CROSS-PROJECT COMMUNICATION AND COORDINATION (ADMIN CORE); AIM #2: PROVIDE EXPERT CONSULTATION AND TECHNICAL ASSISTANCE TO NETWORK PROJECTS REGARDING RESEARCH DESIGN AND STATISTICAL METHODS, AS WELL AS ESTABLISH THE DATA INFRASTRUCTURE TO FACILITATE CROSS-SITE DATA COLLECTION, MANAGEMENT, HARMONIZATION, LINKAGE, AND SHARING/ARCHIVING (DATA CORE); AIM #3: ENHANCE THE USE OF COMMUNITY-BASED PARTICIPATORY RESEARCH METHODS, INCLUDING BY FACILITATING A COMMUNITY ETHICS REVIEW FOR EACH PROJECT, ENSURING COMMUNITY VOICE IN THE RESEARCH DESIGN, METHODS, AND RESULTS INTERPRETATION. (COMMUNITY CORE); AIM #4: PROVIDE EXPERT CONSULTATION TO PROJECTS TO INCORPORATE IMPLEMENTATION SCIENCE AND ECONOMIC EVALUATION METHODS TO ENHANCE SUSTAINABILITY (IMPLEMENTATION CORE); AIM #5: DISSEMINATE KEY FINDINGS TO ACADEMICS, POLICY MAKERS, AND COMMUNITY PARTNERS UTILIZING TRADITIONAL AND INNOVATIVE MEDIA (COMMUNICATION CORE). THE PROPOSAL LEVERAGES U-M IFIPS COLLECTIVE EXPERTISE, EXPERIENCE, AND RESOURCES TO AID THE BROADER NETWORK INITIATIVE WORK TO REDUCE FIREARM INJURIES, AND ASSOCIATED DISPARITIES.

MICHIGAN CENTER FOR DIABETES TRANSLATIONAL RESEARCH

GUT-BRAIN AXIS IN METABOLIC DISEASE

CENTER FOR RADIATIVE SHOCK HYDRODYNAMICS (CRASH)

TARGETING ENZYMATIC REGULATION OF FETAL HEMOGLOBIN REPRESSION

THIS COOPERATIVE AGREEMENT SHALL BE PERFORMED IN ACCORDANCE WITH THE STATEMENT OF WORK , ENTITLED: 'TRANSMUTER: A RECONFIGURABLE COMPUTER'

THE DEVELOPMENT OF THERAPEUTIC AND DIAGNOSTIC COUNTERMEASURES TO WMD BY THE ADVANCED MEDICAL COUNTERMEASURES CONSORTIUM

LIVING DONOR LIVER TRANSPLANT DATA COORDINATING CENTER

MULTIDISCIPLINARY CARDIOVASCULAR RESEARCH TRAINING

MOLECULAR MECHANISMS OF NEUROMUSCULAR INTERACTIONS UNDERLYING AGE-RELATED ATROPHY

UNIVERSITY TRANSPORTATION CENTERS

IN VIVO IMAGING OF NEOPLASIA

OBJECTIVES|THE PRIMARY MISSION OF THE CENTER FOR MAGNETIC ACCELERATION, COMPRESSION, AND HEATING (MACH) IS TO SUPPORT THE NEEDS OF THE STOCKPILE STEWARDSHIP PROGRAM (SSP) IN THE AREA OF PULSED-POWER-DRIVEN HEDP. THIS INCLUDES IMPROVING OUR UNDERSTANDING OF FUNDAMENTAL HED SCIENCE; EXPLOITING OUR UNDERSTANDING TO DEVELOP NEW AND EXCITING CONCEPTS AND APPLICATIONS; DEVELOPING AND STEWARDING NEXT-GENERATION PULSED POWER TECHNOLOGY AND DRIVERS; LEADING, GROWING, AND DIVERSIFYING THE PULSED POWER HEDP COMMUNITY (INCLUDING PARTICIPATION IN THE Z FUNDAMENTAL SCIENCE PROGRAM (ZFSP) AND THE NASCENT ZNETUS CONSORTIUM); TRAINING THE NEXT GENERATION OF HED SCIENTISTS AND ENGINEERS; AND PARTNERING WITH NNSA/DEFENSE LABORATORIES TO ENSURE HEALTHY STANG PIPELINES AND STRONG SCIENCE-BASED MISSION ALIGNMENT.

MRSEC: CENTER FOR MATERIALS INNOVATIONS AT MICHIGAN -NON-TECHNICAL DESCRIPTION: THIS CENTER FOR MATERIALS INNOVATIONS AT MICHIGAN WILL ESTABLISH A TRANSFORMATIVE CAMPUS-WIDE ECOSYSTEM TO ACCELERATE THE DESIGN, DISCOVERY, AND DEPLOYMENT OF NOVEL MATERIALS CRITICAL FOR THE INDUSTRIES OF TOMORROW, INCLUDING ADVANCED MANUFACTURING, CLEAN ENERGY/SUSTAINABILITY, ARTIFICIAL INTELLIGENCE, AND FUTURE SEMICONDUCTORS. EMBEDDED IN THE ECOSYSTEM IS A LONG-TERM PARTNERSHIP BETWEEN UM RESEARCHERS AND COLLABORATORS FROM INDUSTRY, ACADEMIA, AND NATIONAL LABORATORIES. BUILDING UPON THE PRINCIPLES OF THE MATERIALS GENOME INITIATIVE, THE INTERDISCIPLINARY RESEARCH GROUPS COMBINE COMPUTATIONAL, STATISTICAL, THEORETICAL, AND EXPERIMENTAL APPROACHES TO EXAMINE PROCESSING-STRUCTURE-PROPERTY RELATIONSHIPS IN NOVEL SEMICONDUCTOR HETEROSTRUCTURES FOR ADVANCED QUANTUM INFORMATION PROCESSING AND RECONFIGURABLE POLYMERS THAT ARE ENVIRONMENTALLY SUSTAINABLE. THE CENTER STRUCTURE EMPHASIZES THE INTEGRATION OF RESEARCH AND EDUCATION, WITH AN EMPHASIS ON ATTRACTING/RETAINING THE NEXT GENERATION OF MATERIALS RESEARCHERS: A DIVERSE BODY OF RESEARCHERS REFLECTING SOCIETY AT LARGE. TO BUILD AND MAINTAIN THE CAMPUS-WIDE ECOSYSTEM, THE CENTER WILL WORK TO ENGAGE ALL MATERIALS RESEARCHERS THROUGH A SUITE OF ACTIVITIES AIMED AT BROADENING PARTICIPATION AND ENHANCING KNOWLEDGE TRANSFER. THE CENTER IS POSITIONED TO RESPOND TO EMERGING OPPORTUNITIES THROUGH ITS SEED PROJECTS. TECHNICAL DESCRIPTION: THE CENTER FOR MATERIALS INNOVATIONS AT MICHIGAN WILL ESTABLISH TWO INTERDISCIPLINARY RESEARCH GROUPS. IRG1, ENDOTAXIAL 2D POLYTYPE HETEROSTRUCTURES, WILL DEFINE A NEW CLASS OF MATERIALS WHEREIN DISTINCT POLYTYPES ARE SYNTHESIZED WITHIN EACH OTHER (ENDOTAXY), TO CREATE ROBUST, NOVEL QUANTUM STATES AT ULTRA-CLEAN 2D INTERFACES. THE APPROACH CONSISTS OF COMPUTATIONALLY-DRIVEN PREDICTION OF ENDOTAXIAL MATERIALS AND THEIR DISTINCT PROPERTIES, FOLLOWED BY SYNTHESIS OF ENDOTAXIAL MATERIALS COMPATIBLE WITH NANOELECTRONICS PROCESSING, DISCOVERY OF NOVEL QUANTUM STATES, AND DEMONSTRATION OF ENDOTAXIAL DEVICES. THESE PREVIOUSLY ELUSIVE QUANTUM STATES ARE EXPECTED TO ENABLE RAPID PROGRESS IN CLASSICAL AND QUANTUM INFORMATION PROCESSING. IRG2, COVALENT ADAPTABLE NETWORKS (CAN) FOR SUSTAINABLE AND REGULATABLE FUNCTIONAL MATERIALS, AIMS TO DISCOVER AND DEPLOY NEW POLYMERIC MATERIALS WITH HIGHLY REACTIVE CROSSLINKER MOLECULES FORMING REVERSIBLE COVALENT BONDS BETWEEN CHAINS, IMPARTING SELF-HEALING, RECONFIGURATION, AND RECYCLING CAPABILITIES. THE APPROACH CONSISTS OF COMBINING SIMULATION-BASED AND DATA-DRIVEN DESIGN OF CROSSLINKER ARCHITECTURES WITH A REVISED VISCOELASTICITY THEORY TO PREDICT THE RESPONSIVENESS OF CAN SYSTEMS TO THERMAL, MECHANICAL, AND PHOTONIC STIMULI. SYNTHESIS, CHARACTERIZATION, AND ANALYSIS OF APPLICATION-SPECIFIC PERFORMANCE CRITERIA FOR THE MOST PROMISING DESIGNS WILL RESULT IN NEW FUNDAMENTAL UNDERSTANDING THAT ENABLES THE DEVELOPMENT OF RAPIDLY RECYCLABLE PLASTICS, RECURRENTLY SELF-HEALING STRUCTURAL COMPOSITES, NEW ADDITIVE MANUFACTURING ROUTES, SELF-TRIGGERED MECHANICAL METAMATERIALS, AND FUNCTIONAL MATERIALS WHOSE PROPERTIES CAN BE REGULATED ON DEMAND. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

CELLULAR AND MOLECULAR BIOLOGY AT MICHIGAN

EARLY PHASE CLINICAL CANCER PREVENTION CONSORTIUM

GENETICS AND GENOMICS OF LEIOMYOSARCOMA (LMS): IMPROVED UNDERSTANDING OF CANCER BIOLOGY AND NEW APPROACHES TO DIAGNOSIS AND TREATMENT - OVERALL: PROJECT SUMMARY / ABSTRACT THIS SPORE ENTITLED, GENETICS AND GENOMICS OF LEIOMYOSARCOMA (LMS): IMPROVED UNDERSTANDING OF CANCER BIOLOGY AND NEW APPROACHES TO DIAGNOSIS AND TREATMENT, REPRESENTS A COLLABORATIVE INITIATIVE WITH STRONG EXPERTISE IN SARCOMA INVESTIGATION, EPIDEMIOLOGY, AND CANCER GENETICS. OUR PRIMARY GOALS INCLUDE ADVANCING KNOWLEDGE REGARDING THE IMPACT OF SOMATIC AND GERMLINE MUTATION OF TP53 AND OTHER DNA REPAIR GENES ON THE PATHOGENESIS OF LEIOMYOSARCOMA AS WELL AS TRANSLATIONAL AND CLINICAL RESEARCH STUDIES TO FACILITATE SIGNIFICANT AND TANGIBLE IMPROVEMENTS IN THE SURVIVAL AND QUALITY OF LIFE OF SARCOMA PATIENTS. ALTHOUGH SARCOMAS ARE A DIVERSE GROUP OF MALIGNANT TUMORS, WE FOCUS ON LEIOMYOSARCOMA, A COMMON SOFT TISSUE SARCOMA, THAT IS MORE FREQUENT IN WOMEN (UTERINE LMS), BLACK AMERICANS AND OLDER ADULTS. LMS BECAUSE OF ITS CHROMOSOMAL INSTABILITY, HAS A CLINICAL BEHAVIOR SIMILAR TO OTHER SOFT TISSUE SARCOMAS INCLUDING UNDIFFERENTIATED PLEOMORPHIC SARCOMA, DEDIFFERENTIATED LIPOSARCOMA, MYXOFIBROSARCOMA AND MPNST. LMS IS MOST OFTEN AGGRESSIVE, AND TREATMENTS ARE GENERALLY LACKING. SARCOMAS LIKE LEUKEMIAS AND LYMPHOMAS, ARE MESODERMAL MALIGNANCIES AND CARRY BIOLOGICAL SIGNIFICANCE DISPROPORTIONATE TO THEIR CLINICAL PREVALENCE. THE DIVERSE HISTOTYPES OF SARCOMA, AND ITS RELATIVE RARITY, DEMAND THAT TRANSLATIONAL AND CLINICAL SARCOMA RESEARCH BE CONDUCTED IN THE CONTEXT OF MULTI-DISCIPLINARY, MULTI-INSTITUTIONAL INITIATIVES. THE PROJECTS ARE: (1) GENOMIC VULNERABILITIES IN LEIOMYOSARCOMA; (2) UNDERSTANDING THE ROLE OF TP53 IN LMS DEVELOPMENT; AND (3) APPLYING LIQUID BIOPSY TECHNOLOGIES TO DETECT CLINICAL RESPONSE AND MECHANISMS OF RESISTANCE IN THE TREATMENT OF LMS. THE PROJECTS ARE INTEGRATED WITH HIGH FUNCTIONING CORES AND PROGRAMS FOR CAREER ENHANCEMENT AND DEVELOPMENTAL PROJECTS. THIS MULTI-INSTITUTIONAL SPORE WILL INVESTIGATE CONTEMPORARY AND FUNDAMENTAL ISSUES IN SARCOMA RESEARCH, WITH ITS MAJOR FOCUS ON TRANSLATIONAL RESEARCH INCLUDING THE DEVELOPMENT OF NEW THERAPIES AND RELEVANT CLINICAL BIOMARKERS. PROJECT 1 IDENTIFIED AN IMPORTANT NEW TARGET IN DNA REPAIR WHICH IS SO POTENT IT PERMITS COMBINATION WITH LOW DOSE DOXORUBICIN AND INTRODUCES THIS NEW THERAPY IN ADVANCED DRUG DEVELOPMENT STUDIES AND A PHASE 1/2 TRIAL. PROJECT 3 PURSUES DETECTION OF LMS ULTRA-RARE TUMOR FRAGMENTS FOUND IN PERIPHERAL BLOOD. QUANTIFICATION OF THIS CTDNA PERMITS ACCURATE ASSESSMENT OF TUMOR BURDEN AND ACCELERATES EXPLORATION OF TUMOR EVOLUTION. PROJECT 2 IS A GENETIC EPIDEMIOLOGY STUDY FOCUSING ON RISK FOR SPORADIC LMS AS WELL AS SECONDARY TO LI-FRAUMENI SYNDROME. THE EMPHASIS WILL BE ON TP53 GENE, WHICH IS SOMATICALLY MUTATED IN ALMOST (92%) ALL LMS PATIENTS AND OTHER GENES AFFECTING DNA REPAIR. PATIENTS WITH LI-FRAUMENI HAVE GERMLINE MUTATION OF THIS GENE.

AN ENGINEERING RESEARCH CENTER IN WIRELESS INTEGRATED MICROSYSTEMS

PRENATAL PROGRAMMING OF REPRODUCTIVE HEALTH AND DISEASE

TREATING MILD COGNITIVE IMPAIRMENT WITH TRANSCRANIAL DIRECT CURRENT STIMULATION

COMPARATIVE MODELING OF LUNG CANCER PREVENTION AND CONTROL POLICIES

PIVOTAL AND DIVERSE ROLES FOR MATRICELLULAR PROTEINS IN MUSCULOSKELETAL DISORDERS

HEALTH AND RETIREMENT STUDY: HARMONIZED COGNITIVE ASSESSMENT PROTOCOL (HCAP)

MICHIGAN CENTER FOR HEALTH COMMUNICATIONS RESEARCH II

BEHAVIOR ON SURVEYS AND IN THE ECONOMY USING HRS

SEXUAL DIMORPHISM OF NEURAL DEVELOPMENT UNDERLYING CHILDHOOD STUTTERING

THE ROLE OF THE GUT MICROBIOTA IN ULCERATIVE COLITIS

ARRHYTHMIA MECHANISMS IN TWO INHERITED CARDIAC DISEASES

ALTERNATIVE VACUOLAR TARGETING MECHANISMS IN YEAST

HUNTING FOR MYOCARDIAL INFARCTION GENES BY COMBINED GENOME AND EXOME SEQUENCING

IMPROVING HBF INDUCTION BY INHIBITING EPIGENETIC TARGET ENZYMES

ENHANCING RETROSPECTIVE LIFE HISTORY DATA IN THE HEALTH AND RETIREMENT STUDY

DATANET FULL PROPOSAL: SUSTAINABLE ENVIRONMENT THROUGH ACTIONABLE DATA (SEAD)

KPMP KIDNEY MAPPING AND ATLAS PROJECT (KMAP) - ABSTRACT THE OVERARCHING OBJECTIVE OF THE KIDNEY MAPPING ATLAS PROJECT (KMAP) IN RESPONSE TO THE KIDNEY TISSUE ATLAS COORDINATING CENTER (KTACC) APPLICATION IS TO CREATE AND SUPPORT THE CENTRAL DATA MANAGEMENT, INTEGRATION AND DISSEMINATION PLATFORM FOR THE KIDNEY PRECISION MEDICINE PROJECT (KPMP). OUR FOCUS FOR THE KMAP WILL BE CENTERED AROUND THE KEY VALUES ESTABLISHED BY US IN THE FIRST FUNDING CYCLE OF KPMP: A COLLABORATIVE ENVIRONMENT COMMITTED TO PROMOTING PARTICIPANT SAFETY AND ENGAGEMENT, SCIENTIFIC RIGOR, AND OUTREACH TO THE GLOBAL RENAL RESEARCH COMMUNITY ANCHORED IN A CONCEPT OF INTERDISCIPLINARY TEAM SCIENCE NECESSARY TO DRIVE DISRUPTIVE ADVANCES IN KIDNEY PRECISION MEDICINE. WE PLAN TO EXTEND OUR HIGHLY EXPERIENCED TEAM SUCCESSFULLY NAVIGATING THE MULTIPLE INHERENT CHALLENGES DURING THE STARTUP PHASE OF KPMP TO ADDRESS THE KEY OPPORTUNITIES AND CHALLENGES OF THE NEXT PHASE OF KPMP. TO THIS END HAVE ASSEMBLED DOMAIN EXPERTISE IN NEPHROLOGY, NEPHRO- AND DIGITIAL PATHOLOGY, ANATOMY, ONTOLOGY, DATA CURATION, BIOSTATISTICS, BIOINFORMATICS, RENAL SYSTEMS BIOLOGISTS, DATA VISUALIZATION, KIDNEY USER EXPERIENCE, WEBSITE AND SOFTWARE DEVELOPMENT. OUR OVERARCHING PRINCIPLE WILL CONTINUE TO BE AN UNCOMPROMISING COMMITMENT TO OUR PATIENT PARTNERS CO-LEADING OUR EFFORTS AND A SHARP FOCUS ON RIGOROUS QC AND QC IN TIGHT COORDINATION WITH THE KPMP CENTRAL HUB, THE TISSUE INTERROGATION AND RECRUITMENT SITES AND OPPORTUNITY POOL AWARDEES. WE HAVE PIONEERED A TEAM SCIENCE STRUCTURE TO ADVANCE A PRECISION MEDICINE APPROACH TO KIDNEY DISEASE WITH THE DEVELOPMENT OF THE KPMP DATA MANAGEMENT, INTEGRATION AND SHARING FRAMEWORK STRONGLY ROUTED IN FAIR PRINCIPLES. WE SHARE A COMMON PHILOSOPHY THAT OUR ROLE IS ONE OF SERVICE, COLLABORATION, AND LEADERSHIP WITH OVER 30 YEARS OF EXPERIENCE COORDINATING HIGHLY SUCCESSFUL LARGE-SCALE RESEARCH STUDIES INTO THE MOLECULAR MECHANISM OF KIDNEY DISEASE ALWAYS SUPPORTING DIVERSITY, EQUITY AND INCLUSION IN ALL ASPECTS OF RENAL PRECISION MEDICINE RESEARCH. THE KMAP WILL BE LED BY DRS. KRETZLER (UNIVERSITY OF MICHIGAN) AND HIMMELFARB (UNIVERSITY OF WASHINGTON) WITH COMPLEMENTARY EXPERTISE AND AN EXTENSIVE TRACK RECORD IN WORKING TOGETHER TO LEAD CLINICAL, TRANSLATIONAL AND BENCH KIDNEY PRECISION MEDICINE STUDIES AND WILL ENSURE THE SEAMLESS INTEGRATION OF KMAP INTO THE KPMP ECOSYSTEM. KMAP WILL SERVE ITS FUNCTION VIA THREE MAIN UNITS. THE KMAP DATA MANAGEMENT CORE (DMC) WILL BE RESPONSIBLE TO CLEAN, HARMONIZE, REGISTER, STORE AND CURATE THE DIVERSE CURRENT AND FUTURE KPMP DATA. THE KMAP DATA ANALYSIS HUB (DAH) WILL INTEGRATE THE MULTIMODAL DATA ALONG THE CONTINUUM OF CLINICAL, SOCIAL-RISK, SPATIAL, ONTOLOGICAL, DIGITAL-PATHOLOGY AND MOLECULAR DATA SETS TO IDENTIFY KEY DRIVERS OF DISEASE PROCESSES. FINALLY, THE KMAP DATA VISUALIZATION HUB (DAV) WILL DEVELOP, MAINTAIN AND DISTRIBUTE A MULTI-DIMENSIONAL ATLAS OF KIDNEY HEALTH AND DISEASE VIA A FLEXIBLE COMPUTATION ENVIRONMENT. TIGHT INTEGRATION OF THE KMAP EFFORTS WITH HUBMAP, HCA AND RBK/GUDMPA TOGETHER WITH STRONG LEADERSHIP SKILLS OF THE PIS WILL ENSURE EFFECTIVE IMPLEMENTATION ACROSS KPMP AND THE BIOMEDICAL COMMUNITY AT LARGE.

PEPTIDE HORMONE SORTING TO THE SECRETORY/STORAGE GRANULE

IMPROVING SURVIVAL IN ORAL CANCER BY DISRUPTION OF TUMOR PROGRESSION

YOUTH VIOLENCE, VICTIMIZATION, SUICIDE, AND BULLYING ARE PERVASIVE IN THE UNITED STATES. SAFE SCHOOLS ARE FUNDAMENTAL TO PREVENTING VIOLENCE AND PROMOTING ACADEMIC ACHIEVEMENT, MENTAL HEALTH, AND PROSOCIAL BEHAVIOR. ENSURING SAFETY FOR ALL STUDENTS AND THE SCHOOL COMMUNITY REQUIRES A COMPREHENSIVE, MULTISECTORAL, AND EQUITABLE APPROACH INCORPORATING EVIDENCE-BASED (EB) PRACTICES TAILORED TO LOCAL NEEDS. YET, SCHOOLS OFTEN LACK CAPACITY AND KNOWLEDGE OF EB STRATEGIES TO EFFECTIVELY IMPLEMENT SCHOOL SAFETY INITIATIVES. COMPREHENSIVE TRAINING AND TECHNICAL ASSISTANCE (TTA), BASED ON STRONG EVIDENCE AND CONTINUOUS EVALUATION, CAN HELP SCHOOLS ADDRESS THESE BARRIERS AND SUPPORT EFFECTIVE SCHOOL SAFETY PROGRAMMING. ATTENDING TO EQUITY WITHIN SCHOOL CONTEXTS IS ALSO AT THE FOREFRONT, AND IS CRITICAL TO PREVENT DISPROPORTIONATE EFFECTS OF SCHOOL SAFETY PRACTICES. THE NATIONAL CENTER FOR SCHOOL SAFETY (NCSS) WILL CONTINUE TO INCREASE CAPACITY OF CURRENT AND FUTURE STOP SCHOOL VIOLENCE PROGRAM GRANTEES TO ADAPT, IMPLEMENT, EVALUATE, AND SUSTAIN EB AND EQUITABLE SCHOOL SAFETY PROGRAMS AND SERVE AS A RESOURCE FOR SCHOOL SAFETY BEST PRACTICES TO THE FIELD NATIONWIDE. TO MEET THIS GOAL, THE NCSS WILL: 1) EXPAND THEIR MULTIDISCIPLINARY TEAM OF SUBJECT MATTER EXPERTS TO GUIDE THE DEVELOPMENT AND IMPLEMENTATION OF EB RESOURCES AND SERVICES; 2) PROVIDE TAILORED AND SPECIALIZED TA TO ENSURE EQUITABLE ACCESS AND IMPLEMENTATION OF COMPREHENSIVE SCHOOL SAFETY PROGRAMMING; 3) ESTABLISH PEER NETWORKING AND ADVANCED LEARNING OPPORTUNITIES OF SCHOOL SAFETY PRACTITIONERS NATIONWIDE; 4) CONDUCT AN ANNUAL NEEDS ASSESSMENT AND IMPLEMENTATION AND OUTCOME EVALUATION OF TTA TO ENSURE QUALITY AND CONTINUOUS IMPROVEMENT OF SERVICES; AND 5) FACILITATE INFORMATION SHARING AND SERVE AS A RESOURCE FOR SCHOOL SAFETY BEST PRACTICES FOR THE SCHOOL AND CRIMINAL JUSTICE COMMUNITY. THE NCSS WILL WORK IN PARTNERSHIP WITH AN EXPANSIVE MULTIDISCIPLINARY NETWORK OF PUBLIC HEALTH, EDUCATION, LAW ENFORCEMENT, MENTAL HEALTH, AND EQUITY PRACTITIONERS AND RESEARCHERS WITH EXPERTISE IN TWELVE FOCAL AREAS OF SCHOOL SAFETY. THE TTA PLAN IS TAILORED TO MEET GRANTEES NEEDS AND INCLUDES: PROACTIVE TA WITH EVALUATION AND COMMUNICATIONS SUPPORT, SPECIALIZED SUPPORT ON RISK ASSESSMENTS, REPORTING SYSTEMS, AND THREAT ASSESSMENT; COMPREHENSIVE TOOLKITS, VIDEOS, WEBINARS, GUIDES; IN-PERSON TRAININGS, COMMUNITIES OF PRACTICE, PEER-TO-PEER SITE VISITS, AND SEQUENTIAL LEARNING PATHS; AND ANNUAL GRANTEE CONFERENCES, SPECIALIZED TTA PROVIDER MEETINGS, AND EXPERT CONVENINGS TO DISCUSS TRENDS, EMERGING ISSUES, AND SHARE LESSONS LEARNED WITH GRANTEES, BJA, AND THE FIELD. THESE ACTIVITIES WILL BE INFORMED BY ANNUAL NEEDS ASSESSMENTS WITH SPECIAL CONSIDERATION OF SUBGROUPS, BJA INPUT, AND RIGOROUS EVALUATION TO ENSURE SERVICES AND RESOURCES ARE MEETING THE NEEDS OF GRANTEES AND COMMUNITIES SERVED.

MICHIGAN SEA GRANT OMNIBUS FY 2018-2021

MICHIGAN IRACDA: TRAINING FUTURE PROFESSORS OF ENGINEERING AND PHYSIOLOGY

BIOMEDICAL RESEARCH TRAINING IN THE BIOLOGY OF AGING

CTRIP: MOLECULAR PHENOTYPES OF RAPIDLY PROGRESSIVE IDIOPATHIC PULMONARY FIBROSIS

NOVEL TARGETS IN THROMBOSIS AND ATHEROSCLEROSIS

GENE INTERACTION IN DEVELOPMENT AND DISEASE

EXTRACORPOREAL CIRCULATION WITHOUT ANTICOAGULATION

EXPLORING PRECISION CANCER MEDICINE FOR SARCOMA AND RARE CANCERS

A RADICAL ENZYME AND ITS ESCORTS