Ripple Inc

IMPLANTABLE MYOELECTRIC RECORDING ARRAY FOR CONTROL OF PROSTHESES

IMPLANTABLE RECORDING AND INTEGRATED STIMULATION (IRIS) DEVICE FOR CORTICAL EXPERIMENTS

CLINICAL VALIDATION OF MYOELECTRIC IMPLANT FOR INTUITIVE PROSTHESIS CONTROL - ABSTRACT THE GOAL OF THIS TRANSLATIONAL NIH SBIR PROGRAM IS TO EVALUATE A SMALL, IMPLANTABLE SYSTEM FOR RECORDING MYOELECTRIC SIGNALS FROM RESIDUAL MUSCLES OF INDIVIDUALS WITH FOREARM AMPUTATIONS. THE SIGNALS WILL BE WIRELESSLY COUPLED TO AN EXTERNAL TRANSCEIVER FOR CONTROLLING A PROSTHESIS. COMPARED TO CONVENTIONAL SURFACE ELECTRODES, THIS SYSTEM WILL PROVIDE: - MORE CHANNELS FOR PROSTHESIS CONTROL FROM A LARGER NUMBER OF MUSCLES IN THE RESIDUAL LIMB, - IMPROVED SPECIFICITY AND REPEATABILITY FOR RECORDING FROM INDIVIDUAL MUSCLES AND MUSCLE GROUPS, - HIGHER RELIABILITY AND QUALITY FOR THE RECORDED SIGNALS UNDER DIFFERENT SOCKET CONDITIONS, - SELECTIVE, CONSISTENT SIGNALS FROM DEEP MUSCLES, AND - THE ABILITY TO USE GEL, VACUUM, AND OTHER PROSTHESIS SOCKET LINING SYSTEMS THAT DO NOT EASILY ACCOMMODATE SURFACE ELECTRODES. THESE MULTICHANNEL RECORDINGS WILL ENABLE USERS TO GENERATE SIMULTANEOUS MULTI-AXIS MOVEMENTS WITH A MORE NATURAL FEEL OF CONTROL THAN EXISTING MYOCONTROLLERS THAT ONLY ACTUATE A SINGLE JOINT AXIS AT A TIME. IN PHASE I, WE WILL COMPLETE UPGRADES AND TESTING OF THE EXTERNAL TRANSCEIVER TO ELIMINATE THE NEED OF THE BELT-WORN PROCESSOR. IN PHASE II, WE WILL CONDUCT AN EARLY FEASIBILITY IDE STUDY IN CONJUNCTION WITH THE UNIVERSITY OF PITTSBURGH. WE WILL COORDINATE NATIONWIDE RECRUITMENT ALONG WITH ADVANCED ARM DYNAMICS TO ENROLL A SUFFICIENT NUMBER OF SUBJECTS TO IMPLANT 5 SUBJECTS WITH THE MYOELECTRIC IMPLANT FOR A 1-YEAR STUDY. SUBJECTS WILL BE IMPLANTED AND UNDERGO QUARTERLY EVALUATION AT THE UNIVERSITY OF PITTSBURGH THROUGHOUT THE 1-YEAR TAKE-HOME STUDY. THE IMPLANT WILL BE EVALUATED FOR SAFETY AND EFFICACY FOR CONTROLLING A MULTI-ARTICULATING PROSTHETIC LIMB.

WIRELESS SUBDURAL ELECTRODE ARRAY

IMPLANTABLE PERIPHERAL NERVE STIMULATOR FOR TREATMENT OF PHANTOM LIMB PAIN

BLINK PROSTHESIS FOR FACIAL PARALYSIS PATIENTS

BLINK PROSTHESIS FOR FACIAL PARALYSIS PATIENTS

WORKFLOW OPTIMIZATION FOR TUNING PROSTHESES WITH HIGH INPUT CHANNEL COUNT

TYPE I INTERFERON IMPACTS TREATMENT RESPONSE IN RHEUMATOID ARTHRITIS - RHEUMATOID ARTHRITIS (RA) IS A COMMON MULTISYSTEM INFLAMMATORY CONDITION. DELAY IN EFFECTIVE TREATMENT RESULTS IN INCREASED MORBIDITY AND MORTALITY, AND A HEAVY ECONOMIC BURDEN. CURRENT TREATMENT STRATEGIES ARE EMPIRIC BECAUSE WE HAVE NO MARKERS TO SUGGEST WHICH THERAPY IS BEST FOR AN INDIVIDUAL. TUMOR NECROSIS FACTOR INHIBITORS (TNFI) ARE THE MOST COMMON INITIAL BIOLOGIC TREATMENT IN RA. RESPONSES ARE VARIABLE, WITH APPROXIMATELY 30% NOT RESPONDING AND ANOTHER 30% HAVING ONLY PARTIAL RESPONSE. WE HAVE SHOWN IN TEST AND VALIDATION COHORTS THAT PRE-TREATMENT CIRCULATING TYPE I IFN (T1IFN) PREDICTS NON-RESPONSE TO TNFI. PRE-TREATMENT IFN-SS TO IFN-A ACTIVITY RATIO >1.3 WAS STRONGLY PREDICTIVE OF NON-RESPONSE TO TNFI (SPECIFICITY=77% IN THE VALIDATION COHORT). NO PATIENT WITH A RATIO >1.3 ACHIEVED REMISSION OR LOW DISEASE ACTIVITY. WE USED SINGLE CELL ANALYSIS TO STUDY BLOOD MONOCYTE (MO) GENE EXPRESSION IN RA PATIENTS WITH HIGH VS. LOW IFN-SS-TO-A ACTIVITY RATIO AND FOUND MAJOR DIFFERENCES BETWEEN THE GROUPS, SUPPORTING DOWNSTREAM EFFECTS UPON A CRITICAL EFFECTOR CELL POPULATION. PRESENCE OR ABSENCE OF JAK1 EXPRESSION STRONGLY ALIGNED WITH IFN-SS-TO-A RATIO. IN RA, BLOOD MO INVADE SYNOVIUM, AND LOCAL STIMULI DRIVE EXPANSION OF INFLAMMATORY MACROPHAGE (MF) POPULATIONS. IT IS NOT KNOWN WHETHER THE CIRCULATING IFN RATIO IN RA REFLECTS T1IFN LEVELS AND PATHWAY ACTIVATION IN THE SYNOVIUM, AND THIS WILL BE EXAMINED IN AIM 1. THE RELATIVE CONTRIBUTIONS OF BLOOD VS. SYNOVIAL SIGNALS IN THE DIAPEDESIS AND DIFFERENTIATION OF MO TO INFLAMMATORY MO/MFS IS NOT KNOWN. THIS WILL BE EXPLORED IN AIM 2 USING A NOVEL PERFUSABLE ORGAN-ON-A-CHIP SYSTEM. HYPOTHESIS: RA TNFI NON-RESPONDERS HAVE INCREASED BLOOD AND SYNOVIAL IFN-SS/A RATIO THAT RESULTS IN ALTERED EXPRESSION OF JAK1 AND IFN-STIMULATED GENES, INCREASED DIAPEDESIS AND DIFFERENTIATION OF MO INTO INFLAMMATORY MFS. I WILL EXPLORE THIS OVERARCHING HYPOTHESIS IN 2 SPECIFIC AIMS: (1) DETECT DIFFERENCES IN T1IFN, PATHWAY ACTIVATION, AND HISTOPATHOLOGY IN SYNOVIUM OF RA PATIENTS WHO HAVE A EULAR GOOD RESPONSE OR NO RESPONSE TO TNFI. (2) DETERMINE THE IMPACT OF IFN-A AND IFN-SS ON RA MO, MO-DERIVED MF, AND FIBROBLAST-LIKE SYNOVIOCYTES. I WILL GAIN NEW SKILLS BIASED AND UNBIASED ANALYSES, DATA ARCHITECTURE/ARTIFICIAL INTELLIGENCE, AND IN USE OF A BIOENGINEERED MICROPHYSIOLOGICAL SYSTEM TO INTERROGATE HUMAN RA BIOLOGY, WHICH I NEED TO SUCCESSFULLY LAUNCH AND ESTABLISH MYSELF AS AN INDEPENDENT INVESTIGATOR ADVANCING PRECISION MEDICINE IN RA. RESULTS WILL PROVIDE FERTILE GROUND FOR FUTURE DIRECTIONS. SELECT COURSEWORK WILL COMPLEMENT MY RESEARCH AND FORTIFY MY SKILLS. PRESENTING, PUBLISHING, AND SUBMITTING GRANTS WILL SHARPEN MY ABILITIES. I AIM TO USE CELL BIOLOGY, IMMUNOLOGY, AND CONTEMPORARY APPROACHES TO UNDERSTAND DIFFERENCES AMONG RA PATIENTS AND ALLOW FOR PROGNOSTICATION AND A TREATMENT APPROACH TAILORED TO AN INDIVIDUAL’S DISEASE AND PERSONAL IMMUNOLOGY. NYU IS HEAVILY INVESTED WITH THE RESOURCES AND INFRASTRUCTURE TO PROMOTE BASIC, CLINICAL AND TRANSLATIONAL RESEARCH. THE DENSITY OF HIGH CALIBER SCIENTISTS AND COLLEGIAL ENVIRONMENT IS IDEAL FOR AN ESI TRANSITIONING TO INDEPENDENCE. SUPPORT FROM A K08 IS VITAL IN MY EFFORTS TO EXPAND MY RESEARCH SKILLS AND EMPOWER MY INDEPENDENT CAREER.

PHOTOSENSITIVITY AND LYMPH NODE IMMUNE RESPONSES IN LUPUS

TREAT IMPLANT LOOSENING OF PERCUTANEOUS OSSEOINTEGRATED PROSTHETIC LIMBS WITH INTERMITTENT PARATHYROID HORMONE

CDFI RAPID RESPONSE PROGRAM AWARD

PURPOSE: TO PROMOTE ECONOMIC REVITALIZATION AND COMMUNITY DEVELOPMENT THROUGH INVESTMENT IN AND FINANCIAL ASSISTANCE TO COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS (CDFIS). PLANNED ACTIVITIES: FINANCIAL ASSISTANCE MUST BE USED FOR FINANCIAL PRODUCTS, FINANCIAL SERVICES (REGULATED INSTITUTIONS ONLY), DEVELOPMENT SERVICES, LOAN LOSS RESERVES, AND CAPITAL RESERVES (REGULATED INSTITUTIONS ONLY), IN AN ELIGIBLE MARKET OR THE RECIPIENT’S APPROVED TARGET MARKET. END GOALS: THE GOAL OF THE FINANCIAL ASSISTANCE IS FOR CDFIS TO BUILD THEIR FINANCIAL CAPACITY TO LEND TO ELIGIBLE MARKETS AND/OR THEIR TARGET MARKETS, IN ORDER TO SERVE RURAL AND URBAN LOW INCOME PEOPLE, AND COMMUNITIES ACROSS THE NATION THAT LACK ADEQUATE ACCESS TO AFFORDABLE FINANCIAL PRODUCTS AND FINANCIAL SERVICES. BENEFICIARIES: PROFIT ORGANIZATION, PRIVATE NONPROFIT INSTITUTION/ORGANIZATION, OTHER PRIVATE INSTITUTION/ORGANIZATION INVESTMENT AREAS AND TARGETED POPULATIONS, AS DEFINED IN 12 C.F.R. 1805. SUBRECIPIENTS: THERE ARE NO SUBRECIPIENTS FOR THIS PROGRAM. BROADBAND: SPECIFIC ACTIVITIES RELATING TO BROADBAND USAGE ARE NOT KNOWN AT THE TIME OF AWARD. REASON/PURPOSE OF MODIFICATION: THE RIEGLE ACT (P.L. 103 325), THE STATUTE WHICH AUTHORIZES THE CDFI PROGRAM, REQUIRES THAT FINANCIAL ASSISTANCE AWARDS, INCLUDING BASE FINANCIAL ASSISTANCE (BASE FA), DISABILITY FUNDS FINANCIAL ASSISTANCE (DF FA), AND PERSISTENT POVERTY COUNTIES FINANCIAL ASSISTANCE (PPC FA), BE MATCHED WITH FUNDS FROM NON FEDERAL GOVERNMENT SOURCES AND COMPARABLE IN FORM AND VALUE TO THE FA AWARD. MODIFICATIONS WOULD BE REQUIRED IF THERE IS A CHANGE IN THE FORM AND/OR AMOUNT ORIGINALLY OBLIGATED FOR THE AWARD, BASED ON APPROVED MATCHING FUNDS. NOTE: MATCHING FUNDS ARE REQUIRED ONLY FOR ORGANIZATIONS APPLYING AS CATEGORY II/CORE FA APPLICANTS UNDER THE CDFI PROGRAM. MATCHING FUNDS ARE NOT REQUIRED FOR ANY NATIVE CDFI APPLICANTS OR HOUSING PRODUCTION FINANCIAL ASSISTANCE AWARDS (HP FA). ADDITIONALLY, MATCHING FUNDS ARE NOT REQUIRED FOR SMALL AND EMERGING CDFI ASSISTANCE (SECA) FA APPLICANTS AND HEALTHY FOOD FINANCING INITIATIVES (HFFI) FA APPLICANTS, PENDING FINAL FY 2025 APPROPRIATIONS LANGUAGE.

PURPOSE: TO PROVIDE GRANTS TO COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS (CDFIS) FOR THE FOLLOWING PURPOSES 1) TO EXPAND LENDING, GRANT MAKING AND INVESTMENT ACTIVITIES IN LOW OR MODERATE INCOME COMMUNITIES AND TO BORROWERS THAT HAVE HISTORICALLY EXPERIENCED SIGNIFICANT UNMET CAPITAL AND FINANCIAL SERVICES NEEDS AND WERE DISPROPORTIONATELY IMPACTED BY THE COVID 19 PANDEMIC; AND 2) TO ENABLE CDFIS TO BUILD ORGANIZATIONAL CAPACITY AND ACQUIRE TECHNOLOGY, STAFF, AND OTHER TOOLS NECESSARY TO ACCOMPLISH THE ACTIVITIES UNDER A CDFI ERP AWARD. PLANNED ACTIVITIES: ELIGIBLE ACTIVITIES INCLUDE FINANCIAL PRODUCTS, FINANCIAL SERVICES, DEVELOPMENT SERVICES, GRANTS, LOAN LOSS RESERVES AND CAPITAL RESERVES THAT MAY BE USED TO MITIGATE THE IMPACT OF THE COVID 19 PANDEMIC ON UNEMPLOYMENT, CHILDCARE, HEALTHCARE, MENTAL HEALTHCARE, AFFORDABLE HOUSING, AFFORDABLE HOUSING FINANCE, SMALL BUSINESS, SMALL FARMS, BROADBAND INTERNET, AND FOOD SUFFICIENCY. IN ADDITION, TO SUPPORT CDFIS IN BUILDING THEIR CAPACITY TO RESPOND TO THE ECONOMIC IMPACT OF COVID 19, CDFI ERP AWARDS MAY BE USED FOR COMPENSATION PERSONAL SERVICES; COMPENSATION FRINGE BENEFITS; PROFESSIONAL SERVICE COSTS; TRAVEL COSTS; TRAINING AND EDUCATION COSTS; EQUIPMENT; SUPPLIES. END GOALS: EXPANDED FINANCING FOR LOW TO MODERATE INCOME COMMUNITIES AND INDIVIDUALS THAT HAVE HISTORICALLY EXPERIENCED SIGNIFICANT UNMET CAPITAL AND FINANCIAL SERVICES NEEDS AND WERE DISPROPORTIONATELY IMPACTED BY THE COVID 19 PANDEMIC INCLUDING SPECIFIC DESIGNATED COVID IMPACTED CDFI ERP ELIGIBLE GEOGRAPHIES AS AREAS THAT MAY BENEFIT FROM CDFI ERP ASSISTANCE. BENEFICIARIES: CERTIFIED CDFIS WHICH MAY BE FOR PROFIT ORGANIZATION, PRIVATE NONPROFIT INSTITUTION/ORGANIZATION, AND OTHER PRIVATE INSTITUTION/ORGANIZATION, AS DEFINED IN 12 C.F.R. 1805, AND LOW AND MODERATE INCOME INDIVIDUALS AND FAMILIES. SUBRECIPIENTS: THERE ARE NO SUBRECIPIENTS FOR THIS PROGRAM. BROADBAND: SPECIFIC ACTIVITIES RELATING TO BROADBAND USAGE ARE NOT KNOWN AT THE TIME OF AWARD. REASON/PURPOSE OF MODIFICATION: NOT APPLICABLE.

RESEARCHING THE ECONOMIC FEASIBILITY OF THE MIXED-CELL RACEWAY, PROVIDING A WAY FOR SMALL FARMS TO ENTER THE AQUACULTURE INDUSTRY.

HEALTH CARE AND OTHER FACILITIES

CLOSED-LOOP LARYNGEAL PACING FOR VOICE RESTORATION - PROJECT SUMMARY AND ABSTRACT THE MOST COMMON NEUROGENIC VOICE DISORDER IS UNILATERAL VOCAL FOLD PARALYSIS (UVFP), WHICH CAN SUBSTANTIALLY REDUCE QUALITY OF LIFE. CURRENT AVAILABLE SURGICAL TREATMENTS OFFER ONLY TEMPORARY IMPROVEMENT IN VOICE THROUGH PLACEMENT OF RESORBABLE MATERIALS OR INVOLVE PERMANENT, INVASIVE ALTERATION OF THE LARYNX THAT INCOMPLETELY RESTORES VOICE AND OFTEN REQUIRES REVISION SURGERIES. THERE IS LIMITED ACCESS TO ADVANCED SURGICAL PROCEDURES WITH MODERATELY BETTER OUTCOMES DUE TO THE NEED FOR SPECIALIZED SURGICAL TECHNIQUES AND AN INCREASED RISK OF INVASIVE PROCEDURES. FUNCTIONAL ELECTRICAL STIMULATION (FES) HAS THE POTENTIAL TO RESTORE DYNAMIC VOCAL FOLD (VF) CLOSURE (ADDUCTION), IMPROVING VOICE AND AIRWAY PROTECTIVE OUTCOMES FOR THE UVFP PATIENT POPULATION. LARYNGEAL ELECTROMYOGRAPHY (LEMG) STUDIES HAVE SHOWN THAT ABOUT 85% OF THOSE WITH CHRONIC UVFP DO NOT HAVE COMPLETE VF DENERVATION, OPENING THE DOOR TO LOW-INTENSITY CLOSED-LOOP FES TO REANIMATE PARALYZED VFS. SEVERAL STUDIES HAVE INDEED SHOWN THAT LARYNGEAL MUSCLES WITH SYNKINETIC REINNERVATION CAN BE EFFECTIVELY STIMULATED OR “PACED” TO RESTORE DYNAMIC VF OPENING (ABDUCTION). HOWEVER, LARYNGEAL PACING DEVICES TO DATE HAVE ONLY STIMULATED VF ABDUCTION TO FACILITATE BREATHING AND HAVE ONLY USED PRESET PATTERNS OF STIMULATION (OPEN-LOOP CONTROL) RATHER THAN SENSING AND RESPONDING TO THE PHYSIOLOGICAL NEEDS OF THE INDIVIDUAL (CLOSED-LOOP CONTROL). HEREIN WE DESCRIBE A NOVEL CLOSED-LOOP LARYNGEAL FES SYSTEM FOR REANIMATION OF VF CLOSURE (ADDUCTION) TO TREAT UVFP. THE PROPOSED SYSTEM BUILDS UPON PROVEN APPROACHES FOR IMPLANT DEVICES AND FES, YET INCLUDES MULTIPLE KEY INNOVATIVE ELEMENTS, AND WILL CREATE AN ENTIRELY NEW MEDICAL DEVICE TAILORED FOR REANIMATION OF PARALYZED VF ADDUCTION TO SUPPORT VOICE AND AIRWAY PROTECTION.

CONFOCAL MICROSCOPY SYSTEM

COMPLEMENT AS A MEDIATOR OF RECURRENT MISCARRIAGES

SPERM EPIGENETIC DIAGNOSTIC TO INFORM COUPLES TIME TO PREGNANCY - SUMMARY THIS APPLICATION IS FOR AN STTR PHASE I PROJECT AIMED AT DEVELOPING A SPERM-SPECIFIC TEST TO PREDICT THE TIME IT TAKES FOR COUPLES TO CONCEIVE. INFERTILITY IS ONE OF THE MOST COMMON REPRODUCTIVE HEALTH DISORDERS, AFFECTING 17% OF COUPLES IN THE U.S. NOTABLY, INFERTILITY HAS HISTORICALLY BEEN TREATED AS A FEMALE ISSUE; HOWEVER, AROUND HALF OF ALL INFERTILITY CASES ARE PARTIALLY OR COMPLETELY ATTRIBUTED TO MALE FACTORS. CLINICAL MALE INFERTILITY IS TYPICALLY ASCERTAINED BASED ON SEMEN-QUALITY REFERENCE VALUES ESTABLISHED BY THE WORLD HEALTH ORGANIZATION (WHO) CRITERIA; HOWEVER, THESE CRITERIA ARE POOR PREDICTORS OF REPRODUCTIVE SUCCESS, RAISING QUESTIONS ABOUT THE SIGNIFICANCE AND RELIABILITY OF CONVENTIONAL METHODS FOR EVALUATING MALE FERTILITY. DESPITE SIGNIFICANT ADVANCES IN UNDERSTANDING THE MOLECULAR CHARACTERISTICS OF SEMEN, MEASURES OF MALE FERTILITY HAVE REMAINED UNCHANGED FOR DECADES. THEREFORE, THE DEVELOPMENT OF NOVEL BIOMARKERS OF MALE REPRODUCTIVE HEALTH IS VITAL TO IMPROVING REPRODUCTIVE CLINICAL CARE. SPERMATOGENESIS REQUIRES DYNAMIC REPROGRAMMING OF THE EPIGENOME TO ENABLE THE PROGRESSION FROM DIPLOID SPERMATOGONIA TO HAPLOID MATURE SPERMATOZOA. WE PROPOSE THAT THE ROBUST EPIGENETIC REPROGRAMMING DURING SPERMATOGENESIS PROVIDES A FINAL OPPORTUNITY FOR SPERM TO “EPIGENETICALLY MATCH” WITH THEIR INTERNAL FACTORS (E.G., GENETICS) AND EXTERNAL FACTORS (E.G., ENVIRONMENT) PRIOR TO CONCEPTION. IN RECENT YEARS, EPIGENETIC CLOCKS, WHICH ESTIMATE BIOLOGICAL AGE, HAVE BEEN DEVELOPED AS NOVEL BIOMARKERS FOR PHENOTYPES SUCH AS CANCER AND MORTALITY. IMPORTANTLY, OUR GROUP WAS THE FIRST TO DEVELOP A SPERM-SPECIFIC EPIGENETIC CLOCK, WHICH HAS BEEN ASSOCIATED WITH COUPLES’ PREGNANCY OUTCOMES AND VALIDATED IN AN INDEPENDENT INFERTILITY COHORT. THIS APPLICATION WILL LEVERAGE OUR MACHINE LEARNING PIPELINE AND EXTANT SPERM METHYLATION DATA, ALONG WITH REPRODUCTIVE OUTCOME DATA FROM 1,825 COUPLES FROM BOTH THE GENERAL POPULATION AND INFERTILITY COHORTS, TO FURTHER OPTIMIZE AND VALIDATE A NEW SPERM EPIGENETIC CLOCK THAT PREDICTS REPRODUCTIVE OUTCOMES. THE RESEARCH PROPOSED IN THIS APPLICATION WILL OPTIMIZE AND VALIDATE OUR PREDICTION MODELS ACROSS THREE DISTINCT COHORTS, DEMONSTRATING THE FEASIBILITY OF OUR PRODUCT AS A POTENTIAL MALE FERTILITY DIAGNOSTIC TOOL TO INFORM CLINICAL DECISION-MAKING AND SUPPORT THE MANAGEMENT OF COUPLES SEEKING TO ACHIEVE PREGNANCY IN BOTH CLINICAL AND NON-CLINICAL SAMPLES.

NOVEL MECHANISMS THAT PREVENT SLE

MICRO-COMPUTED TOMOGRAPHY SYSTEM (MICRO-CT)

MULTILAYER FLEXIBLE ELECTRODES FOR CHRONIC ELECTROMYOGRAPHIC RECORDING

THIS PROJECT PROPOSES AN EXPANSION, IMPROVEMENT, AND MORE ROBUST SYSTEM-WIDE IMPLEMENTATION OF AN EXISTING INITIATIVE CALLED PUDDLES TO FLOODS SUMMER INSTITUTE (P2F). WITH FUNDING FROM NOAA B-WET, WE WILL (1) EXTEND THE REACH OF P2F TO OFFER ALIGNED MWEE INSTRUCTIONAL UNITS THAT TAKE PLACE DURING THE SCHOOL YEAR (2) DESIGN AND ENACT A PROFESSIONAL DEVELOPMENT STRAND FOR SCHOOL-BASED INSTRUCTIONAL COACHES, AND (3) BUILD A SHARED UNDERSTANDING OF, AND DISTRICT-WIDE INVESTMENT IN, A SOPHISTICATED INSTRUCTIONAL VISION FOR SCIENCE TEACHING. DELIVERY METHODS INCLUDE FIELD EXPERIENCES FOR TEACHERS, ADMINISTRATORS, AND STUDENTS; SUMMER INSTITUTE IMMERSIVE PROFESSIONAL DEVELOPMENT AND REGULAR SCHOOLYEAR TEACHING; VIRTUAL AND IN-PERSON PROFESSIONAL LEARNING COMMUNITY MEETINGS, WORKSHOPS, INTERNAL AND EXTERNAL PRESENTATIONS TO SHARE AND DISCUSS PROGRAM EVALUATION RESULTS VIA WEBINAR AND IN PERSON.

SBIR PHASE I: UNIVERSAL TAGGING AND COLLABORATION SYSTEM

ASSISTANCE TO FIREFIGHTERS GRANTS

COLLABORATIVE RESEARCH: KNOWN RIVERS: CREATING JUSTICE-CENTERED WATER LITERACY ALONG THE LOWER MISSISSIPPI RIVER -MARGINALIZED COMMUNITIES DISPROPORTIONATELY EXPERIENCE THE EFFECTS OF ENVIRONMENTAL DEGRADATION SUCH AS SINKING INFRASTRUCTURE, URBAN FLOODING, AND COASTAL LAND LOSS AS A RESULT OF LEGACIES OF SEGREGATION AND LACK OF ACCESS TO RESOURCES. TO SUPPORT YOUTH IN BLACK AND AFRO-INDIGENOUS COMMUNITIES IN SOUTHEAST LOUISIANA, THE RESEARCH TEAM WILL WORK COLLABORATIVELY WITH LOCAL COMMUNITY ORGANIZATIONS TO DEVELOP AND ENACT A JUSTICE-CENTERED FRAMEWORK FOR WATER LITERACY THAT RESPONDS TO CHILDREN?S EXPERIENCES AND CONCERNS ABOUT THE ENVIRONMENTAL WATER ISSUES THAT IMPACT THEIR EVERYDAY LIVES. THE PROJECT WILL CONTRIBUTE TO KNOWLEDGE OF HOW COMMUNITY-ENGAGED SCIENCE CURRICULUM AND TEACHING PROJECTS BUILD RELATIONSHIPS BETWEEN COMMUNITIES AND SCHOOLS AND HOW STUDENTS AND TEACHERS GRAPPLE WITH THE JUSTICE DIMENSIONS OF ISSUES THAT HAVE DISCIPLINARY AND SOCIAL IMPLICATIONS. IN PARTNERSHIP WITH A NETWORK OF PUBLIC CHARTER SCHOOLS IN NEW ORLEANS, LOUISIANA, THE RESEARCH TEAM WILL ENGAGE IN FOUR YEARS OF DESIGN-BASED RESEARCH THAT CENTERS COMMUNITY KNOWLEDGE AND LIVED EXPERIENCE. GUIDED BY A STEERING COMMITTEE OF LOCAL WATER-FOCUSED COMMUNITY LEADERS AND ORGANIZATIONS, THE TEAM WILL WORK WITH APPROXIMATELY 16 TEACHERS AND 640 STUDENTS IN GRADES 3?8 TO DEVELOP AND STUDY THE IMPLEMENTATION OF THE JUSTICE-CENTERED WATER LITERACY CURRICULUM UNITS. ADDITIONAL PRODUCTS WILL INCLUDE PROFESSIONAL DEVELOPMENT TOOLS DESIGNED TO AMPLIFY THE COMMUNITY?S EXPERIENTIAL AND HISTORICAL KNOWLEDGE AS CENTRAL TO SCIENCE LEARNING. THIS COLLABORATIVE PROJECT IS FUNDED BY THE EDU RACIAL EQUITY IN STEM EDUCATION ACTIVITY, WHICH IS SUPPORTED BY THE DIRECTORATE FOR STEM EDUCATION (EDU). THIS ACTIVITY SUPPORTS RESEARCH AND PRACTICE PROJECTS THAT INVESTIGATE HOW CONSIDERATIONS OF RACIAL EQUITY FACTOR INTO THE IMPROVEMENT OF SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS (STEM) EDUCATION AND WORKFORCE. PROGRAMS ACROSS EDU CONTRIBUTE FUNDS TO THE RACIAL EQUITY ACTIVITY IN RECOGNITION OF THE ALIGNMENT OF ITS PROJECTS WITH THE COLLECTIVE RESEARCH AND DEVELOPMENT THRUSTS OF THE FOUR DIVISIONS OF THE DIRECTORATE. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

RESEARCHING ECONOMIC FEASIBILITY OF THE MIXED-CELL RACEWAY, PROVIDING A WAY FOR SMALL FARMS TO ENTER THE AQUACULTURE INDUSTRY.

FINAL DEVELOPMENT OF A MYOELECTRIC IMPLANT FOR INTUITIVE PROSTHESIS CONTROL

BASIC SCIENCE OF TENDON TO BONE HEALING

NEUROPHYSIOLOGY AND COGNITIVE NEUROSCIENCE - SHORT-TERM INNOVATIVE PROGRAM

THIS GRANT SUPPORTS THE COSTS INCURRED TO IMPLEMENT MEASURES TO RESPOND TO THE NOVEL CORONAVIRUS 2019 (COVID-19), WHICH MAY INCLUDE WORKPLACE SAFETY, MARKET PIVOTS, RETROFITTING FACILITIES, TRANSPORTATION, WORKER HOUSING, AND MEDICAL EXPENSES. IT PROVIDES NEEDED RELIEF TO THE FOOD PROCESSORS, DISTRIBUTORS, FARMERS MARKETS, AND PRODUCERS FOR THEIR COSTS INCURRED BETWEEN JANUARY 27, 2020, THE DATE UPON WHICH THE PUBLIC HEALTH EMERGENCY WAS DECLARED BY THE U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICE (HHS) UNDER SECTION 319 OF THE PUBLIC HEALTH SERVICE ACT, AND DECEMBER 31, 2021. BENEFICIARIES INCLUDE THE EMPLOYEES OF THE FOOD PROCESSORS, DISTRIBUTORS, FARMERS MARKETS, AND PRODUCERS.

RESEARCHING THE ECONOMIC FEASIBILITY OF THE MIXED-CELL RACEWAY, PROVIDING A WAY FOR SMALL FARMS TO ENTER THE AQUACULTURE INDUSTRY.