Regents Of The University Of Minnesota

INTERNATIONAL NETWORK FOR STRATEGIC INITIATIVES IN GLOBAL HIV TRIALS (INSIGHT)

CANCER CENTER SUPPORT GRANT P30 CA77598-06

CARES ACT INSTITUTIONAL PORTION UMNTC

MIDWEST AVIDD CENTER - PROJECT 5 – PANDEMIC VIRUS HELICASE INHIBITORS ABSTRACT THE GOAL OF THIS PROJECT IS TO DEVELOP PAN-FAMILY, ANTIVIRAL DRUG CANDIDATES TARGETING THE VIRAL HELICASE OF CORONAVIRUS AND FLAVIVIRUS. ALL PRIORITY RNA VIRUSES ENCODE A VIRAL HELICASE DOMAIN IN THEIR GENOMES, AND THEY SHARE HIGH SIMILARITY IN STRUCTURE AND BIOCHEMICAL FEATURES. VIRAL RNA HELICASE IS A CRITICAL COMPONENT OF THE VIRAL REPLICASE COMPLEX AND IS ESSENTIAL FOR RNA VIRUS REPLICATION. FURTHER, IT SHOWS A HIGH SEQUENCE HOMOLOGY WITHIN THE VIRUS FAMILY (E.G., 100% IDENTITY WITHIN SARS2). CONSEQUENTLY, VIRAL RNA HELICASES CAN SERVE AS A NOVEL ANTIVIRAL TARGET FOR RNA VIRUSES WITH A HIGH BARRIER TO DRUG RESISTANCE. DURING THE PAST 10 YEARS, THE CHUNG LAB HAS MADE SIGNIFICANT CONTRIBUTIONS TO THE DEVELOPMENT OF ANTIVIRALS TARGETING THE ALPHAVIRUS HELICASE DOMAIN (NSP2) AND VALIDATED VIRAL HELICASE AS DRUGGABLE FOR DEVELOPING POTENT ANTIVIRALS. BASED ON THIS SUCCESS, WE HYPOTHESIZE THE VIRAL HELICASE CAN SERVE AS A VALID TARGET FOR SAFE AND EFFECTIVE ANTIVIRALS FOR SARS2 AND OTHER PRIORITY RNA VIRUSES. HERE, WE PROPOSE A COMPREHENSIVE ANTIVIRAL DISCOVERY CAMPAIGN TARGETING VIRAL HELICASE WITH A MULTI-DISCIPLINARY APPROACH COMBINING ULTRA-HIGH-THROUGHPUT SCREENING AND DNA-ENCODED CHEMISTRY TECHNOLOGY FOLLOWED BY A ROBUST HIT VALIDATION SCHEME WITH ANTIVIRAL TESTING, STRUCTURAL BIOLOGY, AND BIOCHEMICAL APPROACHES (AIM 1). FURTHER, WE PROPOSE TO ADVANCE PROMISING VIRAL HELICASE INHIBITOR HITS THROUGH HIT-TO-LEAD DEVELOPMENT, GIVING VALIDATED LEADS AS DRUG DEVELOPMENT CANDIDATES WITH MEDICINAL CHEMISTRY PAIRED WITH AI-BASED DRUG DESIGN, DMPK STUDIES, AND IN VIVO ANTIVIRAL EFFICACY STUDIES (AIM 2). FINALLY, WE WILL DELIVER 1-2 ORALLY BIOAVAILABLE, PATENTABLE, DRUGLIKE IND-ENABLED SMALL MOLECULES (A DEVELOPMENT CANDIDATE + BACKUP) THAT ARE WELL-SUITED FOR TRANSLATION BY A PHARMA PARTNER (AIM 3). OUR PROPOSAL IS SUPPORTED BY OUR DISCOVERY OF A NOVEL HIT COMPOUND (UNC0379) WITH AN ANTI-SARS2 ACTIVITY FROM A PILOT 100,000-COMPOUND LIBRARY SCREEN (CORE B). THE PI AND ESTABLISHED TEAM (CHUNG, VIROLOGY/PI; BANNISTER, MED. CHEM/DEPUTY; SPICER, UHTS; LUO, STRUCTURAL BIOLOGY OF VIRAL REPLICASE; RANEY, HELICASE BIOCHEMISTRY) SYNERGISTICALLY COMBINE ANTIVIRAL DRUG DISCOVERY (HEAD-GORDON, COMPCHEM/AI) WITH EXCELLENT CORE SUPPORT (CORE B AND CORE C). OUR EFFORT WILL DELIVER NEW CLASSES OF DIRECT HELICASE-TARGETING ANTIVIRAL AGENTS FOR SARS2 INFECTION AND OTHER HIGH PRIORITY VIRAL PATHOGENS.

INTERNATIONAL NETWORK FOR STRATEGIC INITIATIVES IN GLOBAL HIV TRIALS (INSIGHT): START

CARES ACT STUDENT PORTION UMNTC

EMERGING PANDEMIC THREATS-2

INTERNATIONAL NETWORK FOR STRATEGIC INITIATIVES IN GLOBAL HIV TRIALS (INSIGHT)

COLLABORATIVE RESEARCH AND DEVELOPMENT IN NEUTRINO PHYSICS

UNIVERSITY OF MINNESOTA CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE (UMN CTSI)

UNIVERSITY OF MINNESOTA CLINICAL AND TRANSLATIONALMSCIENCE INSTITUTE (UMN CTSI)

ABCD-USA CONSORTIUM: TWIN RESEARCH PROJECT

WORKER HEALTH AND SAFETY TRAINING COOPERATIVE AGREEMENT

NK CELLS, THEIR RECEPTORS AND UNRELATED DONOR TRANSPLANT

ENGINEERING RESEARCH CENTER FOR COMPACT AND EFFICIENT FLUID POWER

NSF ENGINEERING RESEARCH CENTER FOR ADVANCED TECHNOLOGIES FOR PRESERVATION OF BIOLOGICAL SYSTEMS (ATP-BIO)

BIOLOGY & TRANSPLANTATION OF THE HUMAN STEM CELL

MIDWEST CENTER FOR OCCUPATIONAL HEALTH AND SAFETY

MECHANISMS OF ETHNIC/RACIAL DIFFERENCES IN LUNG CANCER DUE TO CIGARETTE SMOKING

EDUCATIONAL AND EARLY LIFE PREDICTORS OF MILD COGNITIVE IMPAIRMENT: NEW EVIDENCE ABOUT MEDIATORS AND MODERATORS FROM HIGH SCHOOL & BEYOND

GENERAL SUPERVISION ENHANCEMENT GRANT

UPPER MIDWEST AGRICULTURAL SAFETY AND HEALTH CENTER

MECHANISMS OF PERIPHERAL INDUCTION OF T-CELL TOLERANCE

CENTER FOR CHRONIC DISEASE REDUCTION AND EQUITY PROMOTION ACROSS MINNESOTA (C2DREAM) - PROJECT SUMMARY/ABSTRACT – OVERALL A GROWING BODY OF RESEARCH DOCUMENTS THE PROFOUND CONTRIBUTION OF STRUCTURAL AND INTERPERSONAL RACISM TO DISPARITIES IN CHRONIC DISEASE INCLUDING CARDIOVASCULAR DISEASE (CVD) AND THE RELATED CHRONIC CONDITIONS (RCC) OF HYPERTENSION AND OBESITY. IN MINNESOTA, WHERE THE MURDER OF MR. GEORGE FLOYD AT THE HANDS OF POLICE INSTIGATED A LOCAL, NATIONAL, AND GLOBAL RECKONING ON THE PERVASIVENESS OF RACISM, THERE IS AN URGENT NEED TO UNDERSTAND AND ULTIMATELY ADDRESS THE WAYS THAT RACISM UNDERMINES WELL-BEING OF BLACK, INDIGENOUS, AND PEOPLE OF COLOR (BIPOC) COMMUNITIES. THE MISSION OF OUR PROPOSED CENTER FOR CHRONIC DISEASE REDUCTION AND EQUITY PROMOTION ACROSS MINNESOTA (C2DREAM) IS TO REDUCE DISPARITIES IN CVD AND RCC EXPERIENCED BY BIPOC COMMUNITIES INCLUDING IMMIGRANTS AND REFUGEES ACROSS MINNESOTA. OUR 3 PROPOSED INTERVENTION PROJECTS TARGET COMMUNITY AND PRIMARY CARE APPROACHES TO DIET, PHYSICAL ACTIVITY, SMOKING CESSATION, AND OTHER PROXIMAL CONTRIBUTORS TO CVD AND RCC AMONG MINNESOTA’S DIVERSE BIPOC COMMUNITIES. C2DREAM WILL PROMOTE INNOVATIVE, MULTILEVEL INTERVENTIONS THAT TARGET FUNDAMENTAL CAUSES OF HEALTH INEQUITIES AMONG DIVERSE BIPOC COMMUNITIES ACROSS MINNESOTA; GENERATE KNOWLEDGE, ANALYTICAL AND IMPLEMENTATION APPROACHES, AND COMMUNITY ENGAGEMENT STRATEGIES TO UNDERSTAND AND DEVELOP SOLUTIONS TO ADDRESS RACISM AT MULTIPLE LEVELS; DEVELOP AND SUPPORT THE NEXT GENERATION OF HEALTH EQUITY RESEARCHERS; CREATE AND SUSTAIN A COMMUNITY-ENGAGED AND EQUITY-GUIDED DISSEMINATION AND IMPLEMENTATION PROCESSES TO TRANSLATE RESEARCH RESULTS AND KNOWLEDGE REGARDING ADDRESSING CHRONIC DISEASE INEQUITIES INTO ACTION; AND EMPLOY EQUITY-GUIDED EVALUATION APPROACHES. ALL CENTER ACTIVITIES AND RESEARCH PROJECTS ARE ALIGNED WITH A UNIFYING CONCEPTUAL MODEL GUIDED BY THE NIMHD’S MINORITY HEALTH & HEALTH DISPARITIES RESEARCH FRAMEWORK. C2DREAM IS A REGIONAL PARTNERSHIP THAT SPANS THE STATE AMONG THE UNIVERSITY OF MINNESOTA (UMN), INCLUDING THE MEDICAL SCHOOL ON THE TWIN CITIES (CENTRAL) AND DULUTH (NORTHERN) CAMPUSES, AND THE SCHOOL OF PUBLIC HEALTH; MAYO CLINIC INCLUDING ROCHESTER AND COMMUNITY-BASED MAYO CLINIC HEALTH SYSTEM CLINICS (SOUTHERN); AND HENNEPIN HEALTHCARE, A COUNTY-OWNED HMO AND THE STATE’S LARGEST SAFETY NET HOSPITAL (CENTRAL). OUR PARTNERSHIP BUILDS ON MANY FORMAL AND INFORMAL CONNECTIONS ACROSS COLLABORATORS AND INSTITUTIONS, INCLUDING NCATS-FUNDED UMN CLINICAL TRANSLATIONAL SCIENCE INSTITUTE (CTSI) AND MAYO CLINIC CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCES (CCATS) RESOURCES, AS WELL AS EXTENSIVE PARTNERSHIPS WITH KEY COMMUNITY STAKEHOLDERS. OUR TEAM HAS RICH EXPERTISE IN MEASUREMENT OF RACISM AT MULTIPLE LEVELS, HEALTH PROMOTION INTERVENTIONS TARGETING CVD AND RELATED CHRONIC CONDITIONS, BEHAVIORAL MEDICINE, EPIDEMIOLOGY, PUBLIC HEALTH, PSYCHOLOGY, COMMUNITY BASED PARTICIPATORY RESEARCH, POLICY, COMMUNICATIONS, AND IMPLEMENTATION SCIENCE. THIS BREADTH, DEPTH, AND REGIONAL REACH UNIQUELY POSITIONS US TO RIGOROUSLY INVESTIGATE FUNDAMENTAL DRIVERS OF HEALTH INEQUITIES AND GENERATE SOLUTIONS THAT WILL IMPACT MINNESOTA AND THE NATION.

UNIVERSITY OF MINNESOTA CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE (UMN CTSI) - ABSTRACT. CLINICAL AND TRANSLATIONAL SCIENCE (CTS) IS AT THE CROSSROADS OF MAJOR TECHNOLOGY ADVANCES REQUIRING ACADEMIA-COMMUNITY PARTNERSHIPS ANCHORED ON TRUST FOR EFFECTIVE & RAPID DEPLOYMENT OF BEST PRACTICES. UMN CTSA HUB WILL BUILD ON PROVEN COMMITMENTS TO ACCELERATE IMPACTFUL CTS. AIM 1 WILL PROVIDE NOVEL INFRASTRUCTURE TO REDUCE RESEARCH BARRIERS AND ACCELERATE TRANSLATION TO PRACTICE VIA A NEW OFFICE OF CLINICAL RESEARCH AND COMMUNITY AFFAIRS TO AUGMENT CTSI’S CAPACITY TO RESPOND TO AND FACILITATE ROBUST AND SUSTAINABLE COMMUNITY RELATIONSHIPS TRANSCENDING SINGLE INVESTIGATOR PROJECTS. AIM 2 WILL DELIVER HIGH QUALITY AND EFFICIENT RESEARCH SERVICES AND RESOURCES VIA CLINICAL RESEARCH SUPPORT CENTER (85 STAFF) THAT WILL LESSEN TRIAL BARRIERS AND SUPPORT ALL ASPECTS OF STUDY DESIGN, BIOSTATISTICS, BIOINFORMATICS, REGULATORY COMPLIANCE, CONTRACTS AND MORE. ACCELERATING DIVERSITY, EQUITY AND INCLUSION PROGRESS WILL FACILITATE CONNECTIVITY TO OUR DIVERSE POPULATION. A LEARNING HEALTH SYSTEM (LHS) AND CONTINUOUS QUALITY IMPROVEMENT PROGRAM WILL EXPEDITE IMPLEMENTATION OF NOVEL ENHANCEMENTS. AIM 3 WILL CULTIVATE AND TRAIN A STRONG, DIVERSE CTS WORKFORCE WITH NEW TOOLS AND PROGRAMS; DEVELOP AND TEST NOVEL TRIAL PROCESSES AND PARTICIPANT SATISFACTION; THEN DISSEMINATE AND IMPLEMENT LEARNINGS LOCALLY AND NATIONALLY. TAILORED ENHANCEMENTS WILL PERSONALIZE CTS TRAINING FOR COMMUNITY, ACADEMIC AND WORKFORCE PROFESSIONALS, WITH ATTENTION TO DIVERSITY, INFORMED CONSENT FOR NON- ENGLISH SPEAKERS, AN INVESTIGATOR PRIMER, RESEARCH CAREER DEVELOPMENT SERIES AND MORE. CTSI’S RURAL HEALTH PROGRAM OFFERS AN EQUITY POSTDOCTORAL FELLOWSHIP AND YEAR-LONG COMMUNITY LEADER TRAINING IN HEALTH POLICY & LEADERSHIP. CULTURAL COMPETENCY TRAINING WILL FACILITATE ENGAGEMENT WITH OUR MULTICULTURAL COMMUNITY. TRAINED COMMUNITY HEALTH WORKERS (CHWS) WILL ADVANCE RESEARCH DISSEMINATION INTO PRACTICE AND COMMUNITY. AIM 4 WILL FOSTER LEADERSHIP, TEAM SCIENCE AND DATA SHARING TO SUPPORT COLLABORATIONS INCLUDING LEADERSHIP PROGRAMS, PROFESSIONAL COACHING, VERTICALLY INTEGRATED RETREATS, TEAM FUNCTION SEMINARS, NORTHERN LEADERSHIP FOR INNOVATIVE TEAM SCIENCE PROGRAM ADAPTED FOR JUNIOR FACULTY AND INCENTIVES TO GAIN CTSI LEADERSHIP SKILLS. HEALTH INFORMATICS WILL SUPPORT ADVANCED DATA MANAGEMENT, ANALYTIC INFRASTRUCTURES PLUS ELECTRONIC HEALTH RECORD & LHS INFORMATION SYSTEMS. AIM 5 STRIVES FOR HEALTH EQUITY AND AGAINST STRUCTURAL RACISM BY DEPLOYING AN EQUITY FRAMEWORK AND ANTIRACIST RESEARCH PRACTICES TO TRAIN CHWS AND HUB PARTNERS FOR BROAD COMMUNITY INPUT AND DECISION-MAKING. WE WILL BUILD A NATIONAL POPULATION LEVEL GEO-DATABASE OF QUANTIFIABLE MEASURES OF CULTURAL AND ECONOMIC VARIABLES USING A NOVEL MULTIDIMENTIONAL MEASURES OF SYSTEMIC RACISM PORTAL TO LINK HEALTH AND CLINICAL DATA, DEFINE NATIONAL IMPACT OF STRUCTURAL RACISM ON STUDY ENROLLMENT AND DATA COLLECTION WITH A VALIDATION PROJECT ON EARLY CHILDHOOD COGNITIVE FUNCTION AFTER PRENATAL METHAMPHETAMINE EXPOSURE. IMPACT. WITH A NOVEL INFRASTRUCTURE, A DIVERSE NEXT GENERATION OF LEADERS AND A WELL-TRAINED DIVERSE WORKFORCE, OUR HUB AND REGIONAL COMMUNITY WILL CO-DEVELOP AND IMPLEMENT CTS ADVANCEMENTS TO IMPROVE HEALTH.

REVEAL - RESEARCH EVALUATING VAGAL EXCITATION AND ANATOMICAL LINKAGES. - OVERALL ABSTRACT THE VAGUS NERVE IS INVOLVED IN NORMAL PHYSIOLOGY, AND DISTURBANCES IN VAGAL CONTROL HAVE BEEN IMPLICATED IN SEVERAL PATHOPHYSIOLOGICAL CONDITIONS. HOWEVER, THERE IS A LACK OF INFORMATION ON THE PHYSIOLOGY OF THIS NERVE IN HUMANS AS WELL AS MULTI-ORGAN RESPONSES TO VAGAL NERVE STIMULATION (VNS), DESPITE OVER 100,000 VNS IMPLANTS WORLDWIDE TO TREAT EPILEPSY, DEPRESSION, ANXIETY, AND GASTROINTESTINAL DISORDERS. LIKEWISE, VERY LITTLE IS KNOWN ABOUT HOW TO BEST OPTIMIZE VNS SETTINGS FOR EXISTING THERAPIES OR HOW TO DEVELOP VNS FOR NEW THERAPIES. THE PROPOSED RESEARCH EVALUATING VAGAL EXCITATION AND ANATOMICAL LINKAGES (REVEAL) CENTER AIMS TO CONDUCT GROUNDBREAKING RESEARCH ON THE EFFECT OF VNS ON FOUR KEY SYSTEMS: THE AUTONOMIC NERVOUS SYSTEM (ANS), THE CARDIOVASCULAR SYSTEM, THE IMMUNE SYSTEM, AND METABOLIC SYSTEM. THE AMBITIOUS SCOPE OF THE RESEARCH REQUIRES THE PARTICIPATION OF EIGHT MAJOR ACADEMIC AND MEDICAL INSTITUTIONS WITH OVER 40 PARTICIPATING KEY PERSONNEL, OVER 140 PATIENTS, AN EXTERNAL ADVISORY BOARD (WHICH INCLUDES PATIENT ADVOCATES), A DATA AND SAFETY MONITORING BOARD, AND AN NIH STEERING COMMITTEE AND OTHER NIH PERSONNEL. REVEAL WILL HAVE THREE AIMS CORRESPONDING TO ITS CORES. THE CLINICAL CORE WILL MANAGE OVER 140 PATIENTS AND CLINICAL STAFF FROM 8 DIFFERENT INSTITUTIONS TO OBTAIN CONSISTENT DATA ON VNS EFFECTS ON ANS, THE CARDIOVASCULAR SYSTEM, THE IMMUNE SYSTEM, AND METABOLISM. THE DATA AND ANALYSIS CORE WILL GATHER, STORE, AND ANALYZE DATA FROM CLINICAL SITES TO PRODUCE PUBLICLY AVAILABLE DATASETS FOR DEVELOPMENT OF VNS-BASED THERAPEUTICS AND OTHER RESEARCH. THE ADMINISTRATION CORE WILL COORDINATE THE WORK OF THE REVEAL CORES AND STAKEHOLDERS TO MEET THE GOALS OF NIH SPARC’S VESPA PROGRAM.

CARES ACT INSTITUTIONAL PORTION UMD

THE INSTITUTE FOR MATHEMATICS AND ITS APPLICATIONS

ENERGY FRONTIER RESEARCH CENTER FOR INORGANOMETALLIC CATALYST DESIGN

NSF CENTER FOR SUSTAINABLE POLYMERS

CENTER FOR SUSTAINABLE POLYMERS

HEALTH CENTER CLUSTER

THE POLAR GEOSPATIAL CENTER: COMMUNITY AND FACILITY SUPPORT

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

UNIVERSITY OF MINNESOTA MRSEC

DYSFUNCTIONAL STATE REPRESENTATIONS IN PSYCHOSIS: FROM NEUROPHYSIOLOGY TO NEUROPLASTICITY-BASED TREATMENT

STC: NATIONAL CENTER FOR EARTH-SURFACE DYNAMICS

EXTENDED FOLLOW-UP OF RANDOMIZED PARTICIPANTS IN THE INSIGHT START TRIAL

UNIVERSITY OF MINNESOTA MATERIALS RESEARCH SCIENCE AND ENGINEERING CENTER

NATIONAL TAAF TRAINING COORDINATION CENTER

CARES ACT STUDENT PORTION UMD

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP)

UNIVERSITY OF MINNESOTA MATERIALS RESEARCH SCIENCE AND ENGINEERING CENTER

NANOPOROUS MATERIALS GENOME: METHODS AND SOFTWARE TO OPTIMIZE GAS STORAGE, SEPARATIONS, AND CATALYSIS

NATIONAL TAAF TRAINING COORDINATION CENTER

GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP) -THE NATIONAL SCIENCE FOUNDATION (NSF) GRADUATE RESEARCH FELLOWSHIP PROGRAM (GRFP) IS A HIGHLY COMPETITIVE, FEDERAL FELLOWSHIP PROGRAM. GRFP HELPS ENSURE THE VITALITY AND DIVERSITY OF THE SCIENTIFIC AND ENGINEERING WORKFORCE OF THE UNITED STATES. THE PROGRAM RECOGNIZES AND SUPPORTS OUTSTANDING GRADUATE STUDENTS WHO ARE PURSUING RESEARCH-BASED MASTER'S AND DOCTORAL DEGREES IN SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS (STEM) AND IN STEM EDUCATION. THE GRFP PROVIDES THREE YEARS OF FINANCIAL SUPPORT FOR THE GRADUATE EDUCATION OF INDIVIDUALS WHO HAVE DEMONSTRATED THEIR POTENTIAL FOR SIGNIFICANT RESEARCH ACHIEVEMENTS IN STEM AND STEM EDUCATION. THIS AWARD SUPPORTS THE NSF GRADUATE FELLOWS PURSUING GRADUATE EDUCATION AT THIS GRFP INSTITUTION. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.

LYSOSOMAL DISEASE NETWORK

THEORETICAL AND EXPERIMENTAL HIGH ENERGY PHYSICS

INVESTING IN INNOVATION - VALIDATION

HEALTH CENTER CLUSTER

NATIONAL CENTER FOR FOOD PROTECTION AND DEFENSE

ANTIHYPERTENSIVE TREATMENT OF ACUTE CEREBRAL HEMORRHAGE (ATACH-II)

COPD CLINICAL RESEARCH NETWORK - DATA COORDINATING CENT*

MINNESOTA CHEAR EXPOSURE ASSESSMENT HUB

GENOMICS OF KIDNEY TRANSPLANTATION

EXPERIMENTAL RESEARCH AT THE INTENSITY FRONTIER IN HIGH ENERGY PHYSICS

MODELS FOR TOBACCO PRODUCT EVALUATION

CENTER FOR NEURAL CIRCUITS IN ADDICTION

UNIVERSITY OF MINNESOTA CENTER FOR QUANTUM MATERIALS (CQM)

INSTITUTE FOR MATHEMATICS AND ITS APPLICATIONS

CONSORTIUM ON METHODS EVALUATING TOBACCO (COMET): FILTERVENTILATION AND PRODUCT STANDARDS

BII-IMPLEMENTATION: THE CAUSES AND CONSEQUENCES OF PLANT BIODIVERSITY ACROSS SCALES IN A RAPIDLY CHANGING WORLD

UNIVERSITY TRANSPORTATION CENTER

A COMPARTMENTAL ANALYSIS OF HIV RESERVOIRS AND IMMUNE RECONSTITUTION

MEDICARE RURAL HOSPITAL FLEXIBILITY PROGRAM EVALUATION COOPERATIVE AGREEMENT

** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** ?OVERVIEW: AGRICULTURE AND FORESTRY PROVIDE FOOD, FEED, FIBER, FUEL, LUMBER PRODUCTS, AND ENVIRONMENTAL SERVICES WHILE SUSTAINING RURAL AND URBAN ECONOMIES. BUT US GLOBAL COMPETITIVENESS AND NUTRITION SECURITY ARE AT RISK DUE TO UNPREDICTABLE WEATHER EVENTS, DEGRADING AG-FOREST SYSTEM HEALTH, AND AN AGING AND SKILL-DEFICIT WORKFORCE. TO ADDRESS THESE CHALLENGES, WE PROPOSE TO CREATE AN AI FOR LAND, ECONOMY, AGRICULTURE AND FORESTRY (AI-LEAF) DISCIPLINE, A COMMUNITY OF PRACTICE, AND FUNCTIONING CARBON MARKETS BY IMPROVING UNDERSTANDING OF TRADE-OFFS AND FEEDBACK LOOPS BETWEEN RESILIENCE AND ADAPTATION AND BETWEEN BIOMASS PRODUCTIVITY AND CARBON AND WATER FLUXES, DEVELOPING AI-ENHANCED FLUX AND BIOMASS ESTIMATION METHODS AND SPATIALLY-EXPLICIT MULTISCALE (FIELD-TO-MARKET) DECISION SUPPORT TOOLS FOR AGRICULTURE AND FORESTRY. AI ADVANCES WILL INCLUDE RELIABLE, ACCURATE OUT-OF-SAMPLE PREDICTION FROM SPARSE GROUND-TRUTH MEASUREMENTS WITH CONSIDERATION OF HARD CONSTRAINTS, UNCERTAINTY, AND SPATIOTEMPORAL VARIABILITY. WE PROPOSE A VIRTUOUS CYCLE OF DISCOVERY AND INQUIRY IN FOUNDATIONAL AI (FAI) AND USE-INSPIRED RESEARCH (UIR) THAT CONSIDERS DECISION-MAKING AT DIFFERENT SCALES. FAI RESEARCH INCLUDES COMBINING LEARNING AND AI REASONING, AI-AIDED MULTI-OBJECTIVE DECISION-MAKING, AND GENERALIZATION THEORY, ALONG WITH UIR AREAS OF CARBON AND WATER FLUX ESTIMATION, LAND-USE AND CROPPING SYSTEM CHANGE, BIOMASS PRODUCTIVITY, CARBON MARKETS, MULTI-SCALE DECISION SUPPORT TOOLS, KNOWLEDGE-GUIDED MACHINE LEARNING (KGML), COMPUTER-VISION GUIDED PERCEPTION AND ANALYSIS, AND AI-GUIDED DIGITAL TWINS.INTELLECTUAL MERIT: OUR PROPOSED RESEARCH WILL ADVANCE LAND, ECONOMY, AGRICULTURE AND FORESTRY (LEAF) KNOWLEDGE AND UNDERSTANDING TO CREATE LEAF DECISION SUPPORT SYSTEMS USING KGML FOR RELIABLE OUT-OF-SAMPLE PREDICTION (AI) IN UN- OR UNDER-SAMPLED FIELDS AND PARCELS, AND AI-AIDED MULTISCALE AND MULTICRITERIA DECISION SUPPORT TOOLS FOR EVALUATING TRADEOFFS BETWEEN ALTERNATIVE PRACTICES FOR RESILIENCE AND ADAPTATION UNDER CURRENT AND FUTURE CLIMATE SCENARIOS. IT HAS THE POTENTIAL TO TRANSFORM MACHINE LEARNING FROM A SOFT-CONSTRAINT (E.G., REGULARIZERS) AND MONO-OBJECTIVE (E.G., PREDICTION ACCURACY) PARADIGM TO CONFRONT HARD CONSTRAINTS (E.G., MASS AND ENERGY BALANCE) AND MULTIPLE OBJECTIVES (E.G., DECISION MAKING, PREDICTION ACCURACY AND DOMAIN INTERPRETABILITY, ECONOMIC RETURN, AND ECOSYSTEM SERVICES). LIKE IMAGENET, IT HAS THE TRANSFORMATIVE POTENTIAL TO ADVANCE COMPUTER VISION FROM A HUMAN-VISIBLE SPECTRUM AND POINT-CLOUD-BASED APPROACH TO A SENSOR-RICH (E.G., OPTICAL, THERMAL, MICROWAVE) APPROACH BY PUBLISHING NEW LEAF_IMAGENET BENCHMARK DATA AND USE CASES (ESTIMATE CARBON AND WATER FLUXES, SOIL ORGANIC CARBON, BIOMASS PRODUCTIVITY). OUR CORE TEAM HAS A HISTORY OF SYNERGISTIC RESEARCH AND THE REQUIRED SKILLS, EXPERTISE, AND ACCESS TO DATA AND SENSOR RESOURCES. TO FOSTER STRONG INTERACTIONS ACROSS PROPOSED RESEARCH AREAS, WORKFORCE DEVELOPMENT, AND COLLABORATION NEXUS ACTIV,ITIES, A DEDICATED AI INSTITUTE IS NEEDED TO INTEGRATE THE EXPERTISE OF INVESTIGATORS FROM DIVERSE DISCIPLINES AND INSTITUTES IN CLOSE COLLABORATION WITH STAKEHOLDERS TO CULTIVATE A NEW AI-LEAF DISCIPLINE AND COMMUNITY OF PRACTICE.BROADER IMPACT: THE PROPOSED INSTITUTE WILL BENEFIT SOCIETY BY CATALYZING AN AI-LEAF DISCIPLINE, A COMMUNITY OF PRACTICE, AND BETTER FUNCTIONING CARBON MARKETS. IT WILL ENHANCE THE NATIONAL RESEARCH AND EDUCATIONAL INFRASTRUCTURE BY SHARING CURATED DATASETS AND EASY-TO-USE MULTI-SCALE DECISION SUPPORT TOOLS, INCLUDING AI ADVANCES (E.G., KGML, AI-GUIDED MULTI-OBJECTIVE OPTIMIZATION). IT WILL GROW THE AMERICAN AI WORKFORCE VIA THE INTEGRATION OF AI-LEAF RESEARCH WITH EDUCATION; MENTORING OF PROFESSIONAL, POST-DOCTORAL, GRADUATE, AND UNDERGRADUATE STUDENTS; ENGAGEMENT OF SECONDARY SCHOOL TEACHERS AND STUDENTS; AND CO-DEVELOPMENT AND TRAINING OF FARMERS AND FORESTERS IN THE USE OF AI-INSPIRED TOOLS; WITH CAREFUL CONSIDERATION OF BROADENING PARTICIPATION VIA RECRUITMENT, RETENTION, AND PLACEMENT OF ALL PROGRAM PARTICIPANTS. THE TEAM PURPOSEFULLY INTEGRATED RESEARCH, EDUCATION AND EXTENSION ACROSS MULTIPLE DISCIPLINES AND INSTITUTIONS. COMMUNITY-BUILDING ACTIVITIES INCLUDE SHARED DATA AND TOOLS, INTEGRATION OF PARTNERS, AND KNOWLEDGE TRANSFER VIA CO-CREATION, INDUSTRY CONSORTIA, AND THE IP FRAMEWORK.

MEDICARE RURAL HOSPITAL FLEXIBILITY PROGRAM EVALUATION COOPERATIVE AGREEMENT

COMBAT CASUALTY CONSORTIUM

DEEP BRAIN STIMULATION IN THE PARKINSONIAN MONKEY

CENTER FOR SUSTAINABLE ENERGY CATALYSIS (CSEC)

INTEGRATED HEALTH INTERVIEW SERIES

IPUMS REDESIGN RENEWAL

CIRCUIT-BASED DEEP BRAIN STIMULATION FOR PARKINSON'S DISEASE - THE OVERALL GOAL OF THE UNIVERSITY OF MINNESOTA (UMN) UDALL CENTER IS TO DEVELOP NOVEL, CIRCUIT BASED DEEP BRAIN STIMULATION (DBS) THERAPIES FOR PARKINSON’S DISEASE (PD) BASED ON AN UNDERSTANDING OF THE CHANGES IN PATHOPHYSIOLOGICAL ACTIVITY PATTERNS THAT OCCUR IN BASAL GANGLIA THALAMOCORTICAL-BRAINSTEM (BGTC-B) PATHWAYS. PROJECT 1 (HUMAN) WILL CHARACTERIZE THE ROLE OF OSCILLATORY ACTIVITY, COUPLING AND CONNECTIVITY ACROSS THE BROADER BGTC NETWORK, INCLUDING THE SUBTHALAMIC NUCLEUS (STN), GLOBUS PALLIDUS INTERNUS (GPI), SENSORY, MOTOR, PREMOTOR AND DORSOLATERAL PREFRONTAL CORTICES. THESE RECORDINGS WILL BE PERFORMED AT REST AND DURING COGNITIVE- MOTOR TASKS, WITH AND WITHOUT THERAPEUTIC INTERVENTIONS (DBS, L-DOPA, DBS+L-DOPA). IT WILL ALSO CLARIFY THE RELATIVE EFFECT OF STIMULATION IN DIFFERENT FUNCTIONAL SUBREGIONS OF THE STN AND GPI ON MOTOR AND COGNITIVE FUNCTION. PROJECT 2 (HUMAN) WILL EXPLORE THE MECHANISMS AND EFFECTS OF PALLIDAL DBS ON LEVODOPA RESISTANT MOTOR SIGNS USING MRI-DERIVED COMPUTATIONAL MODELS AND FMRI TO EXAMINE THE PATHWAYS MEDIATING THESE CHANGES. IT WILL USE NEW SENSING TECHNOLOGY (PERCEPT) TO IDENTIFY AND CORRELATE THE PHYSIOLOGICAL CHANGES IN THE GP TO WORSENING OF, OR IMPROVEMENT IN, GAIT DYSFUNCTION. PROJECT 3 (NON-HUMAN PRIMATE) WILL EXAMINE THE ELECTROPHYSIOLOGICAL CHANGES IN PALLIDOPEDUNCULAR, PALLIDOINTRALAMINAR, AND PALLIDOHABENULAR ACTIVITY THAT ARE RELATED TO COGNITIVE-MOTOR SYMPTOMS PROVIDING FURTHER NETWORK-LEVEL INSIGHTS INTO COGNITIVE MOTOR GAIT IMPAIRMENTS, TASK SHIFTING DIFFICULTIES, AND LOSS OF MOTIVATION, WHICH WILL COMPLEMENT THE RESULTS FROM THE HUMAN STUDIES IN PROJECTS 1 AND 2. ALL CENTER COMPONENTS HAVE SYNERGISTIC INTERACTIONS WITH THE CATALYST PROJECT, WHICH WILL SUPPORT RESEARCH EFFORTS OF A PROMISING EARLY STAGE INVESTIGATOR WHO WILL USE A NOVEL CLOSED-LOOP DBS APPROACH TO PROBE CIRCUIT DYNAMICS IN PD PATIENTS AND THEIR RELATIONSHIP TO PD MOTOR SIGNS. THE IMAGING CORE WILL ACQUIRE STATE- OF-THE-ART, HIGH-FIELD STRUCTURAL MRI AS WELL AS REST AND TASK-BASED FMRI FOR PD PATIENTS IN PROJECTS 1 AND 2 (USING 7T SCANNER) AND STRUCTURAL MRI FOR THE NHPS IN PROJECT 3 (USING THE FIRST OF ITS KIND 10.5T SCANNER).THE CLINICAL CORE WILL OBTAIN CLINICAL AND QUANTITATIVE MOTOR AND NEUROPSYCHOLOGICAL ASSESSMENTS THAT WILL BE CORRELATED TO PHYSIOLOGICAL DATA OBTAINED ACUTELY IN THE OPERATING ROOM, SUBACUTELY IN PATIENTS WITH EXTERNALIZED DBS LEADS AND ELECTROCORTICOGRAPHY ARRAYS, AND CHRONICALLY THROUGH POSTOPERATIVE RECORDINGS USING PERCEPT. THE BIOSTATISTICS CORE WILL PROVIDE OVERALL DATA MANAGEMENT, QUALITY CONTROL, STATISTICAL AND MACHINE LEARNING ANALYSIS AND DATA ENTRY INTO THE NINDS DATA MANAGEMENT RESOURCE. THE ADMINISTRATIVE CORE WILL ORCHESTRATE ALL ASPECTS OF THE UMN UDALL CENTER, IMPLEMENT AND SUPPORT PATIENT EDUCATION AND PUBLIC OUTREACH EFFORTS, AND DEVELOP AND MONITOR INDIVIDUALIZED CAREER ENHANCEMENT PLANS FOR THE NEXT GENERATION OF PD RESEARCHERS. TOGETHER, THESE APPROACHES WILL PROVIDE CRITICAL DATA TOWARDS THE DEVELOPMENT AND TRANSLATION OF NOVEL PATIENT- SPECIFIC DBS THERAPIES.

** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THIS PROGRAM FUNDS RESEARCH AND EDUCATION/DEMONSTRATION PROJECTS AND PROVIDES TRAINING FOR AGRICULTURAL EDUCATORS AND ISINTENDED TO IMPROVE THE SUSTAINABILITY OF AGRICULTURE, ENCOURAGING PRACTICES THAT ARE ECONOMICALLY VIABLE, CONSERVE OUR NATURAL RESOURCEBASE AND IMPROVE THE QUALITY OF LIFE FOR FARM FAMILIES AND THEIR COMMUNITIES.

IMAGING HUMAN BRAIN FUNCTION WITH MINIMAL MOBILITY RESTRICTIONS

CELL AUTONOMOUS AND NON-AUTONOMOUS MECHANISMS OF AGING

LINKING PRIMARY CARE COMMUNITIES AND FAMILIES TO PREVENT OBESITY AMONG PRESCHOOL

MIDWEST MURINE-TISSUE MAPPING CENTER (MM-TMC) - PROJECT SUMMARY SENESCENT CELLS (SNCS) PLAY A CAUSAL ROLE IN AGING AND NUMEROUS AGE-RELATED DISEASES. HOWEVER, THEY ALSO CONTRIBUTE TO BENEFICIAL BIOLOGY SUCH AS WOUND HEALING AND TISSUE REMODELING. BOTH PHYSIOLOGICAL AND PATHOLOGICAL ROLES ARE LINKED TO THE SECRETOME OF SNCS AND THEIR COMPLEX INTERACTION WITH THE IMMUNE SYSTEM, WHICH IS THOUGHT TO PLAY AN IMPORTANT ROLE IN CLEARING SNCS. MUCH OF WHAT HAS BEEN LEARNED ABOUT SNCS IS DERIVED FROM STUDIES IN MICE, WHERE IT HAS BEEN CLEARLY DEMONSTRATED THAT GENETIC OR PHARMACOLOGIC REMOVAL OF SNCS IN AGED OR DISEASED ORGANISMS REDUCES FRAILTY; IMPROVES STRENGTH, ENDURANCE, AND RESILIENCE; AND ATTENUATES A VARIETY OF AGE-RELATED DISEASES, INCLUDING ALZHEIMER’S. DISCOVERING PHARMACOLOGIC APPROACHES TO REMOVE DISEASE-CAUSING SNCS IN HUMANS COULD HAVE A TREMENDOUS IMPACT ON OUR AGING POPULATION. HOWEVER, MUCH NEEDS TO BE LEARNED ABOUT SNCS TO DEPLOY SUCH APPROACHES SAFELY AND EFFECTIVELY IN HUMANS. THIS PROJECT AIMS TO ESTABLISH A TISSUE MAPPING CENTER (TMC) ACROSS MULTIPLE INSTITUTIONS WITH DEMONSTRATED EXPERTISE IN SNCS AND CELL MAPPING TO ACHIEVE A COMMON GOAL; CONSTRUCTION OF A 4D ATLAS OF SNCS IN MOUSE TISSUES. THE MIDWEST MURINE-TMC (MM-TMC) PROPOSES TO FOCUS ON 5 KEY TISSUES: MOUSE LIVER, ADIPOSE, LUNG, MUSCLE, AND BRAIN. THIS SELECTION IS BASED ON MM-TMC’S EXPERTISE IN THE BIOLOGY, CELL BIOLOGY, AND IMMUNOLOGY OF THESE ORGANS; LENGTHY EXPERIENCE STUDYING SNCS IN THESE ORGANS; AND APPLYING SINGLE CELL AND SPATIAL TECHNOLOGIES TO STUDY THESE ORGANS. THE MM-TMC AND ITS ADMINISTRATIVE CORE WILL BE LED BY PIS WITH COMPLEMENTARY EXPERTISE IN ORGAN BIOLOGY AND SENESCENCE. THE BIOLOGICAL ANALYSIS CORE WILL BE LED BY THREE MPIS WHO HAVE A LONG HISTORY OF COLLABORATION AROUND STUDYING SNCS IN AGED MICE AND WORKING WITH UNIQUE AND INNOVATIVE TRANSGENIC ANIMALS THAT ENABLE THE PRODUCTION OR ABLATION OF LINEAGE-SPECIFIC SNCS. THE DATA ANALYSIS CORE WILL BE LED BY TWO BIOINFORMATICIANS WITH EXPERTISE IN SINGLE CELL ANALYSIS, CELL MAPPING, AND MULTIPLEXING COMPLEX AND DISPARATE DATA SETS TO DEEPLY PHENOTYPE CELLS. OTHER KEY PERSONNEL ADD EXPERTISE IN PATHOLOGY, IMAGING, SPATIAL MAPPING OF SNCS, TISSUE CLEARING, TRANSGENIC MICE, AND DEVELOPMENT OF SENOLYTICS AND IMMUNOTHERAPIES TO TARGET SNCS. A UNIQUE FEATURE OF THE PROPOSED MM-TMC IS THAT THE DATA COLLECTION WILL BE DONE WITHIN EXISTING CORES LARGELY AT THE UNIVERSITY OF MINNESOTA BY STAFF WITH EXPERTISE IN STATE-OF-THE ART SPATIAL MAPPING PLATFORMS. THIS PROVIDES STABILITY IN THE ANALYTICAL PIPELINE AND IN-PLACE QUALITY CONTROL AND ASSURANCE MECHANISMS. THROUGH SYSTEMATIC AND METHODICAL STUDY OF SNCS IN MOUSE TISSUES, THE MM-TMC WILL MAKE SIGNIFICANT CONTRIBUTIONS INFORMING AND VALIDATING THE SENNET HUMAN ATLAS AND WILL WORK CLOSELY WITH NIH, OTHER TMCS, TECHNOLOGY DEVELOPMENT AWARDEES, AND THE CONSORTIUM ORGANIZATION AND DATA COORDINATING CENTER TO DEVELOP AND ADHERE TO STANDARDS CREATED BY SENNET TO ACCELERATE THE PRODUCTION OF RIGOROUS SNC TISSUE MAPS IN BOTH SPECIES.

ADVANCING TRANSPLANTATION TOLERANCE IN NONHUMAN PRIMATES - WHILE SHORT-TERM OUTCOMES FOLLOWING ORGAN TRANSPLANT HAVE GREATLY IMPROVED WITH THE DEVELOPMENT OF MORE EFFECTIVE IMMUNOSUPPRESSION, LONG-TERM OUTCOMES REMAIN PROBLEMATIC WITH A SIGNIFICANT NUMBER OF PATIENTS DEVELOPING DIABETES, ACCELERATED HEART DISEASE AS WELL AS INCREASED RATES OF CANCERS AND INFECTIONS. FOR DECADES TRANSPLANT RESEARCHERS AND CLINICIANS HAVE SOUGHT TO DEVELOP STRATEGIES TO INDUCE IMMUNE TOLERANCE TO TRANSPLANTED ORGANS AND AVOID THE REQUIREMENT FOR LIFE-LONG IMMUNOSUPPRESSION. IT IS LIKELY THAT ANY SUCCESSFUL TOLERANCE REGIMEN WILL INCORPORATE TARGETED IMMUNOSUPPRESSION STRATEGIES LIKE COSTIMULATION BLOCKADE. ONE OF THE MOST IMPORTANT INTERACTIONS IS THE CD40-CD154 PATHWAY. WE WILL EVALUATE NOVEL, CLINICALLY RELEVANT THERAPEUTICS TARGETING EITHER CD40 OR CD154 AND EXPLORE THEIR ROLE IN FACILITATING TOLERANCE. BASED ON OUR RECENT PUBLICATION SHOWING THAT CD11B IS A NOVEL ALTERNATE RECEPTOR FOR CD154 DURING ALLOIMMUNITY, WE WILL ALSO TEST NOVEL NANOTECHNOLOGY TO BLOCK THE CD154:CD11B INTERACTION, AN IMPORTANT MECHANISM OF CROSS-TALK BETWEEN THE INNATE AND ADAPTIVE IMMUNE RESPONSES DURING TRANSPLANTATION. MOREOVER, BASED ON OUR PUBLISHED DATA SHOWING THAT MEMORY T CELLS ARE A POTENT BARRIER TO TRANSPLANTATION TOLERANCE, WE WILL DETERMINE THE ROLE OF OX40-OX40L BLOCKADE TO CONTROL ALLOREACTIVE MEMORY CD8+ T CELLS AND PROMOTE A PRO-REGULATORY ENVIRONMENT. IN ADDITION, WE WILL ASSESS THE IMPORTANCE OF THE VISTA PATHWAY ON THE INDUCTION OF DONOR-SPECIFIC TOLERANCE USING AN AGONISTIC ANTI-HUMAN VISTA ANTIBODY. VISTA HAS A DUAL ROLE IN NEGATIVELY REGULATING ANTIGEN-SPECIFIC T CELL RESPONSES WHILE ALSO IMPACTING THE INNATE IMMUNE RESPONSE BY INHIBITING ISCHEMIA REPERFUSION INJURY, MONOCYTE ACTIVATION AND NEUTROPHIL MIGRATION THEREBY SUPPRESSING THE EARLY INFLAMMATORY RESPONSE. WE WILL ALSO INVESTIGATE THE CONTRIBUTION OF IL-1 AND THE INFLAMMASOME ON TOLERANCE INDUCTION AND EMPLOY CLINICALLY APPLICABLE THERAPEUTICS TO CONTROL EARLY INFLAMMATION DURING THE INDUCTION OF TOLERANCE. THE COMBINATION OF CELLULAR THERAPY AND COSTIMULATION BLOCKADE IS A POWERFUL STRATEGY TO PROMOTE DONOR-SPECIFIC TOLERANCE. MYELOID DERIVED SUPPRESSOR CELLS (MDSCS) HAVE INHERENT IMMUNOSUPPRESSIVE PROPERTIES AND HAVE BEEN USED TO FACILITATE TOLERANCE. THEY MODULATE INNATE IMMUNITY AND INHIBIT T CELL ACTIVATION AND EFFECTOR CELL FUNCTION WHILE ALSO PROMOTING REGULATORY T CELL EXPANSION FOR MAINTENANCE OF LONG-TERM DONOR SPECIFIC TOLERANCE. APOPTOTIC DONOR LEUKOCYTES (ADLS) REPRESENT ANOTHER PROMISING CELLULAR THERAPY THAT HAS BEEN PROVEN TO CONTROL ALLOREACTIVE T CELLS AND PROMOTE DONOR SPECIFIC T CELL DELETION. WE WILL USE DONOR BONE MARROW DERIVED MDSCS OR ADLS IN COMBINATION WITH THE ABOVE NOVEL THERAPEUTICS TO PROMOTE TOLERANCE IN NONHUMAN PRIMATE KIDNEY TRANSPLANTATION.

THIS PROGRAM FUNDS RESEARCH AND EDUCATION/DEMONSTRATION PROJECTS IN THE NORTH CENTRAL REGION AND PROVIDES TRAINING FOR AGRICULTURAL EDUCATORS. IT FUNDS PROJECTS THAT IMPROVE THAT STRENGTHEN AGRICULTURAL SYSTEMS, ENCOURAGING PRACTICES THAT ARE ECONOMICALLY VIABLE, CONSERVE OUR NATURAL RESOURCE BASE AND IMPROVE THE QUALITY OF LIFE FOR FARM FAMILIES AND THEIR COMMUNITIES.IT PROVIDES FUNDING ALLOWING GRANTEES:TO INNOVATE THROUGH PRACTICAL, FARMER-DIRECTED RESEARCH INTO REGENERATIVE AGRICULTURE PRACTICES AND SYSTEMS;TO EXTEND THAT INFORMATION TO FARMERS AND RANCHERS AND TO AGRICULTURAL EDUCATORS TO INCREASE KNOWLEDGE AND AWARENESS OF REGENERATIVE AGRICULTURE SYSTEMS;TO INCREASE THE NUMBER OF FARMERS AND RANCHERS ADOPTING REGENERATIVE AGRICULTURE PRACTICES AND SYSTEMS, IN ORDER TO HELP AGRICULTURE BECOME MORE PROFITABLE, PROTECT NATURAL RESOURCES AND THE ENVIRONMENT, AND IMPROVE QUALITY OF LIFE, LEADING TO THE PRODUCTION OF HEALTHY, SAFE FOOD FOR AMERICAN CONSUMERS AND A SECURE FOOD SYSTEM;TO PROVIDE PROFESSIONAL DEVELOPMENT OR TRAIN THE TRAINER OPPORTUNITIES IN REGENERATIVE AGRICULTURE FOR AGRICULTURAL EDUCATORS IN ORDER TO EQUIP THEM TO SHARE NEW RESEARCH WITH FARMERS AND RANCHERS AND TRAIN THE NEXT GENERATION OF AGRICULTURALISTS

** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THIS PROGRAM FUNDS RESEARCH AND EDUCATION/DEMONSTRATION PROJECTS AND PROVIDES TRAINING FOR AGRICULTURAL EDUCATORS AND ISINTENDED TO IMPROVE THE SUSTAINABILITY OF AGRICULTURE, ENCOURAGING PRACTICES THAT ARE ECONOMICALLY VIABLE, CONSERVE OUR NATURALRESOURCE BASE AND IMPROVE THE QUALITY OF LIFE FOR FARM FAMILIES AND THEIR COMMUNITIES.

INTEGRATED SPATIO-TEMPORAL AGGREGATE DATA SERIES

TECHNOLOGY TO REALIZE THE FULL POTENTIAL OF UHF MRI

MIDWEST DISEASE MODELING AND ANALYTICS PREPAREDNESS CENTER (MDAP)

COLLABORATIVE RESEARCH: PHASE 2 DEVELOPMENT OF A RAPID ACCESS ICE DRILLING (RAID) PLATFORM FOR RESEARCH IN ANTARCTICA

"CENTER OF EXCELLENCE IN HYPERSONICS RESEARCH,"

** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THIS PROGRAM FUNDS RESEARCH AND EDUCATION/DEMONSTRATION PROJECTS AND PROVIDES TRAINING FOR AGRICULTURAL EDUCATORS AND ISINTENDED TO IMPROVE THE SUSTAINABILITY OF AGRICULTURE, ENCOURAGING PRACTICES THAT ARE PROFITABLE, CONSERVE OUR NATURAL RESOURCEBASE AND IMPROVE THE QUALITY OF LIFE FOR FARM FAMILIES AND THEIR COMMUNITIES.

CRITICAL INTERACTIONS OF APOBEC3S: MOLECULAR APPROACHES TO NOVEL HIV THERAPIES

SUBSTANCE ABUSE & BEHAVIORAL DISINHIBITION: INTEGRATING GENES & ENVIRONMENT

COMPLETING THE GRAPEVINE POWDERY MILDEW RESISTANCE PIPELINE: FROM GENES-ON-THE-SHELF TO STICKS-IN-THE-GROUND

TRAINING PROGRAM IN MUSCLE RESEARCH

GRADUATE RESEARCH FELLOWSHIP PROGRAM

A MULTIGENERATIONAL LONGITUDINAL PANEL FOR AGING RESEARCH

**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** ONE OF HUMANITY'S MOST URGENT CHALLENGES IS TO PROVIDE FOOD, FEED, AND FIBER FOR A GLOBAL POPULATION OF 10 BILLION BY 2050. THIS CHALLENGE IS COMPOUNDED BY THE FACT THAT THE WORLD'S CURRENT ANNUAL CROPS AND ANNUAL-BASED CROPPING SYSTEMS ARE DETERIORATING THE ESSENTIAL NATURAL RESOURCE BASE NECESSARY FOR AGRICULTURAL PRODUCTIVITY. IN CONTRAST, PERENNIAL CROPS CAN IMPROVE AGRICULTURAL SUSTAINABILITY BECAUSE THEIR EXTENSIVE ROOT SYSTEMS REDUCE SOIL EROSION, NUTRIENT RUNOFF, AND PESTICIDE REQUIREMENTS WHILE SIMULTANEOUSLY INCREASING FARMER INCOMES DUE TO DECREASED ANNUAL INPUTS AND COSTS. THE DOMESTICATION OF THE WORLD'S FIRST COMMERCIAL-SCALE PERENNIAL GRAIN CROP (INTERMEDIATE WHEATGRASS) IS UNDERWAY IN THE US, AND THE PRODUCT IS TRADE NAMED KERNZA®. THIS PROJECT WILL LEVERAGE AND EXPAND A STRONG EXISTING COLLABORATIVE, CROSS-SECTOR TEAM OF RESEARCHERS, EDUCATORS, FARMERS, BUSINESSES, NON-PROFIT LEADERS, AND OTHERS. THIS TEAM WILL INTEGRATE RECENT EFFORTS AND ADVANCE NEW EFFORTS TO LAUNCH A NEW PERENNIAL GRAIN CROP ENTERPRISE BASED ON KERNZA. PROJECT OBJECTIVES ARE TO ADVANCE BREEDING AND GENETICS, ENHANCE AGRONOMIC KNOWLEDGE, IMPROVE ENVIRONMENTAL QUALITY, ENGAGE EDUCATION, EXTENSION, AND POLICY, AND DEVELOP SUPPLY CHAINS AND ECONOMIC DRIVERS TO ACTIVATE TRANSFORMATIONAL CHANGE IN AGRICULTURE THAT IMPROVES THE ENVIRONMENT AND RURAL PROSPERITY. OUTCOMES WILL INCLUDE KERNZA VARIETY CANDIDATES FOR VARIOUS REGIONS OF THE US, BEST AGRONOMIC RECOMMENDATIONS FOR OPTIMIZING YIELD, PROFITABILITY, AND ENVIRONMENTAL QUALITY, EXPANDED ACREAGE IN ECOLOGICALLY SENSITIVE AREAS TO PROTECT DRINKING WATER FROM NITRATE CONTAMINATION, NEW KERNZA SUPPLY CHAINS AND PRODUCTS, AND AN EDUCATION AND EXTENSION PORTFOLIO OF TOOLS AND EVENTS TO EDUCATE A BROAD RANGE OF STUDENTS AND AGRICULTURE PROFESSIONALS.

TA CENTER ON ASSESSMENT

PROJECT TIES: INCREASING TIME, INSTRUCTIONAL EFFECTIVENESS, ENGAGEMENT, AND SCHOOL SUPPORT FOR INCLUSIVE PRACTICES FOR STUDENTS WITH SIGNIFICANT COGNITIVE DISABILITIES

CENTER FOR MODELING TUMOR CELL MIGRATION MECHANICS

EARLY EXPERIENCE STRESS AND NEUROBEHAVIORAL DEVELOPMENT CENTER

MEDICAL SCIENTIST TRAINING PROGRAM

MURI: MULTISCALE MATHEMATICAL MODELING AND DESIGN REALIZATION OF NOVEL 2 D FUNCTIONAL MATERIALS

REGENTS OF THE UNIVERSITY OF MINNESOTA SMITH-LEVER PROJECT ABSTRACT STATEMENT OF OBJECTIVES AND METHODS FEDERAL AWARD PURPOSE AND ACTIVITIES TO BE PERFORMED UNIVERSITY OF MINNESOTA EXTENSION CONDUCTS RESEARCH PROJECTS AND DELIVERS EXTENSION EDUCATION DESIGNED TO ADDRESS EIGHT CRITICAL ISSUES: 1) CROP, PLANT AND FOOD DEVELOPMENT AND PRODUCTION, 2) INTEGRATED ANIMAL SYSTEMS, 3) NATURAL RESOURCE MANAGEMENT AND WATER QUALITY, 4) SUSTAINABLE ENERGY AND THE BIOECONOMY, 5) HEALTH AND NUTRITION, 6) RESILIENT COMMUNITIES AND ECONOMIES, 7) BUILDING STRONG, RESILIENT FAMILIES, 8) YOUTH DEVELOPMENT. DELIVERABLES AND EXPECTED OUTCOMES EXTENSION BRINGS MINNESOTANS TOGETHER TO BUILD A BEER FUTURE THROUGH UNIVERSITY SCIENCE-BASED KNOWLEDGE, EXPERTISE AND TRAINING. SIMILAR TO IN 2021, EXTENSION EXPECTS TO REACH APPROXIMATELY 568,000 ADULTS AND YOUTH THROUGH DIRECT EDUCATION AND TENS OF THOUSANDS MORE THROUGH PARTNERS. EXTENSION VOLUNTEERS WILL CONTINUE TO COMMIT 950,000+ SERVICE HOURS. EXTENSION WILLDELIVER NEEDED INFORMATION THROUGH WEBSITE CONTENT APPROXIMATELY 12 MILLION TIMES AND PROVIDE PODCASTS, VIDEOS AND SOCIAL MEDIA. AN ONGOING COMMITMENT TO REACH UNDERSERVED AUDIENCES WILL RESULT IN MORE PROGRAMS ACHIEVING PARITY, WITH AN EXPECTED OUTCOME OF A MORE EQUITABLE SOCIETY. INTENDED BENEFICIARIES RURAL, SUBURBAN, URBAN AND TRIBAL STAKEHOLDERS INCLUDE THOSE INVOLVED IN THE CRITICAL ISSUES AT COUNTY, REGIONAL, STATE AND NATIONAL LEVELS. SPECIFIC AUDIENCES INCLUDE: YOUTH AND FAMILIES; FARMERS, FOREST AND SHORELAND OWNERS; OTHER PRODUCERS OF FOOD, FUEL AND TEXTILES; TRIBAL MEMBERS; SMALL BUSINESSES AND LOCAL LEADERS; HOMEOWNERS AND RENTERS; GARDENERS AND COTTAGE FOODS PRODUCERS; LOW-INCOME INDIVIDUALS; MILITARY FAMILIES; PARTNERS; AND NEWCOMERS TO THE U.S.

UNIVERSITY OF MINNESOTA EXTENSION BRINGS MINNESOTANS TOGETHER TO BUILD A BETTER FUTURE THROUGH UNIVERSITY SCIENCE-BASED KNOWLEDGE, EXPERIENCE, AND TRAINING. EXTENSION CONDUCTS RESEARCH PROJECTS AND DELIVERS EXTENSION EDUCATION DESIGNED TO ADDRESS EIGHT CRITICAL ISSUES: 1) CROP, PLANT, AND FOOD DEVELOPMENT AND PRODUCTION, 2) INTEGRATED ANIMAL SYSTEMS, 3) NATURAL RESOURCE MANAGEMENT AND WATER QUALITY, 4) SUSTAINABLE ENERGY AND THE BIOECONOMY, 5) HEALTH AND NUTRITION, 6) RESILIENT COMMUNITIES AND ECONOMIES, 7) BUILDING STRONG, RESILIENT FAMILIES, AND 8) YOUTH DEVELOPMENT. SIMILAR TO 2022, EXTENSION EXPECTS TO REACH APPROXIMATELY 852,000 ADULTS AND YOUTH THROUGH DIRECT EDUCATION AND TENS OF THOUSANDS MORE THROUGH PARTNERS. EXTENSION VOLUNTEERS WILL CONTINUE TO COMMIT 1 MILLION + SERVICE HOURS. EXTENSION WILL DELIVER NEEDED INFORMATION THROUGH WEBSITE CONTENT APPROXIMATELY 14 MILLION TIMES AND PROVIDE PODCASTS, VIDEOS, AND SOCIAL MEDIA. RURAL, SUBURBAN, URBAN, AND TRIBAL STAKEHOLDERS INCLUDE THOSE INVOLVED IN CRITICAL ISSUES AT COUNTY, REGIONAL, STATE, AND NATIONAL LEVELS. SPECIFIC AUDIENCES INCLUDE YOUTH AND FAMILIES; FARMERS, FOREST AND SHORELAND OWNERS; OTHER PRODUCERS OF FOOD, FUEL, AND TEXTILES; TRIBAL MEMBERS; SMALL BUSINESSES AND LOCAL LEADERS; HOMEOWNERS AND RENTERS; GARDENERS AND COTTAGE FOODS P RODUCERS; LOW-INCOME INDIVIDUALS; MILITARY FAMILIES; PARTNERS; AND NEWCOMERS TO THE U.S. SEVERAL PROGRAMS HAVE ACHIEVED PARITY. AN ONGOING COMMITMENT TO REACH UNDERSERVED AUDIENCES WILL RESULT IN MORE PROGRAMS ACHIEVING PARITY IN 2023-2024, WITH AN EXPECTED OUTCOME OF A MORE EQUITABLE SOCIETY.

NEW MATERIALS FROM DUSTY PLASMAS

BUILDING A BETTER FUTURE IN MINNESOTA: ADDRESSING EIGHT CRITICAL ISSUES FEDERAL AWARD PURPOSE AND ACTIVITIES TO BE PERFORMED. UNIVERSITY OF MINNESOTA EXTENSION CONDUCTS RESEARCH PROJECTS AND DELIVERS EXTENSION EDUCATION DESIGNED TO ADDRESS EIGHT CRITICAL ISSUES: 1) CROP, PLANT AND FOOD DEVELOPMENT AND PRODUCTION, 2) INTEGRATED ANIMAL SYSTEMS, 3) NATURAL RESOURCE MANAGEMENT AND WATER QUALITY, 4) SUSTAINABLE ENERGY AND THE BIOECONOMY, 5) HEALTH AND NUTRITION, 6) RESILIENT COMMUNITIES AND ECONOMIES, 7) BUILDING STRONG, RESILIENT FAMILIES, 8) YOUTH DEVELOPMENT. DELIVERABLES AND EXPECTED OUTCOMES. EXTENSION BRINGS MINNESOTANS TOGETHER TO BUILD A BETTER FUTURE THROUGH UNIVERSITY SCIENCE-BASED KNOWLEDGE, EXPERIENCE AND TRAINING. SIMILAR TO 2023, EXTENSION EXPECTS TO REACH APPROXIMATELY 630,000 ADULTS AND YOUTH THROUGH DIRECT EDUCATION, AND TENS OF THOUSANDS MORE THROUGH PARTNERS. EXTENSION VOLUNTEERS WILL CONTINUE TO COMMIT 1 MILLION + SERVICE HOURS. EXTENSION WILL DELIVER NEEDED INFORMATION THROUGH WEBSITE CONTENT APPROXIMATELY 11 MILLION TIMES AND PROVIDE PODCASTS, VIDEOS AND SOCIAL MEDIA. SEVERAL PROGRAMS ACHIEVED PARITY IN 2023. AN ONGOING COMMITMENT TO REACH UNDERSERVED AUDIENCES WILL RESULT IN MORE PROGRAMS ACHIEVING PARITY, WITH AN EXPECTED OUTCOME OF A MORE EQUITABLE SOCIETY. INTENDED BENEFICIARIES INCLUDE RURAL, SUBURBAN, URBAN AND TRIBAL STAKEHOLDERS INCLUDE THOSE INVOLVED IN THE CRITICAL ISSUES AT COUNTY, REGIONAL, STATE AND NATIONAL LEVELS. SPECIFIC AUDIENCES INCLUDE: YOUTH AND FAMILIES; FARMERS, FOREST AND SHORELAND OWNERS; OTHER PRODUCERS OF FOOD, FUEL, AND TEXTILES; TRIBAL MEMBERS; SMALL BUSINESSES AND LOCAL LEADERS; HOMEOWNERS AND RENTERS; GARDENERS AND COTTAGE FOODS PRODUCERS; LOW-INCOME INDIVIDUALS; MILITARY FAMILIES; PARTNERS; AND NEWCOMERS TO THE U.S.

ELEMENTARY NEURONAL ENSEMBLES TO WHOLE BRAIN NETWORKS: ULTRAHIGH RESOLUTION IMAGING OF FUNCTION AND CONNECTIVITY IN HUMANS

FEDERAL AWARD PURPOSE AND ACTIVITIES TO BE PERFORMED. UNIVERSITY OF MINNESOTA EXTENSION CONDUCTS RESEARCH AND DELIVERS EXTENSION EDUCATION DESIGNED TO ADDRESS FIVE LONG-TERM CRITICAL ISSUES: 1) ADVANCING CROP AND PLANT PRODUCTION, 2) BUILDING STRONG YOUTH, FAMILIES AND RURAL ECONOMIES, 3) ENHANCING NUTRITIOUS FOOD DEVELOPMENT, 4) IMPROVING ANIMAL AND LIVESTOCK SYSTEMS, 5) STEWARDING SOIL, WATER AND NATURAL RESOURCES. DELIVERABLES AND EXPECTED OUTCOMES. EXTENSION BRINGS MINNESOTANS TOGETHER TO BUILD A BETTER FUTURE THROUGH UNIVERSITY SCIENCE-BASED KNOWLEDGE, EXPERIENCE AND TRAINING. AS IN 2024, EXTENSION EXPECTS TO REACH OVER 613,000 ADULTS AND YOUTH THROUGH DIRECT EDUCATION, AS WELL AS OVER 1 MILLION PARTICIPANTS VIA ITS 1,888 PARTNERSHIPS. EXTENSION VOLUNTEERS WILL CONTINUE TO COMMIT 1.2 MILLION + SERVICE HOURS. EXTENSION WILL DELIVER NEEDED INFORMATION THROUGH WEBSITE CONTENT APPROXIMATELY 13.4 MILLION TIMES AND PROVIDE PODCASTS, VIDEOS AND SOCIAL MEDIA. INTENDED BENEFICIARIES INCLUDE RURAL, SUBURBAN, URBAN AND TRIBAL STAKEHOLDERS INVOLVED IN THE CRITICAL ISSUES AT COUNTY, REGIONAL, STATE AND NATIONAL LEVELS. SPECIFIC AUDIENCES INCLUDE YOUTH AND FAMILIES; FARMERS, FOREST AND SHORELAND OWNERS; OTHER PRODUCERS OF FOOD, FUEL, AND TEXTILES; SMALL BUSINESSES AND LOCAL LEADERS; HOMEOWNERS AND RENTERS; GARDENERS AND COTTAGE FOODS PRODUCERS; MILITARY FAMILIES; AND PARTNERS IN RESEARCH AND EDUCATION.

INTEGRATED SAMPLES OF EUROPEAN CENSUSES

COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND-GRANT INSTITUTIONS(SMITH-LEVER 3 (B) AND 3 (C) FORMULA) FY22 CAPACITY RFA

EPIDEMIOLOGY OF VENOUS THROMBOSIS & PULMONARY EMBOLISM

BRAIN CONNECTS: CENTER FOR MESOSCALE CONNECTOMICS - PROJECT SUMMARY TO UNDERSTAND COMPLEX NEURAL PATHWAYS AND NETWORKS AND THEIR REMARKABLE ABILITY TO GENERATE HUMAN BEHAVIORS, IT IS CRITICAL TO PRECISELY MAP BRAIN CONNECTOMICS IN VIVO. WE PROPOSE TO MAKE SIGNIFICANT ADVANCES IN SUCH BRAIN MAPPING BY FOUNDING THE CENTER FOR MESOSCALE CONNECTOMICS (CMC). WE WILL FIRST MAP THE MESOSCALE CONNECTIONS BETWEEN THE FRONTAL AND PARIETAL CORTICES. THESE CONNECTIONS LIKELY SUBSERVE HIGHER-ORDER FUNCTIONS SUCH AS ATTENTION, DECISION-MAKING, PROSPECTION, AND EXECUTIVE CONTROL. ONE KEY, UNDERAPPRECIATED FEATURE OF CORTICAL CONNECTIVITY IS ITS SPECIFIC VARIATIONS WITHIN A GIVEN BRAIN REGION, FURTHER SUPPORTING THE CRITICAL NEED FOR DESCRIPTIONS OF CONNECTIVITY AT A FINER SCALE. UNFORTUNATELY, THERE HAS TRADITIONALLY BEEN A MAJOR GAP IN OUR PURSUIT OF CREATING A HUMAN BRAIN “WIRING DIAGRAM” AT HIGH SPATIAL RESOLUTION, ESPECIALLY SINCE THE GOLD STANDARD FOR MESOSCALE BRAIN CONNECTIVITY, ANATOMICAL TRACT-TRACING, CANNOT BE PERFORMED IN HUMANS. MOREOVER, TECHNIQUES THAT CAN BE APPLIED TO HUMANS, SUCH AS DIFFUSION MRI TRACTOGRAPHY, MAY NOT RECAPITULATE ANATOMICAL CONNECTIVITY AT THIS SCALE. DUE TO THIS GAP, WE ARE LACKING AN ACCURATE WIRING DIAGRAM OF THE HUMAN BRAIN THAT CAN ONLY BE OBTAINED THROUGH A MULTI-MODAL, CROSS-SPECIES, MULTI-SCALE APPROACH. HERE, WE PROPOSE TO COMBINE ADVANCED ANATOMICAL TRACT-TRACING (AIM 1), POLARIZATION-SENSITIVE OPTICAL COHERENCE TOMOGRAPHY (PS-OCT) (AIM 2), AND ULTRA-HIGH FIELD DIFFUSION TRACTOGRAPHY (AIM 3) TO CREATE SUCH ACCURATE WIRING DIAGRAMS OF HUMAN AND MACAQUE BRAINS WHILE BRIDGING SPATIAL RESOLUTIONS AND SPECIES. IMPORTANTLY, WE WILL COMPUTATIONALLY BRIDGE SPECIES, METHODS, AND SPATIAL SCALES VIA STATE-OF-THE ART REGISTRATION AND JOINT (MULTIMODAL) MODELING OF FIBER ORIENTATIONS. SUBSEQUENTLY, THE REMARKABLE AMOUNT OF INFORMATION AVAILABLE IN EACH DATASET WILL BE FURTHER ENHANCED USING OPTIMIZED TRACTOGRAPHY METHODS. AT THE END OF THE PROPOSED FUNDING PERIOD, WE EXPECT TO HAVE COMPLETE MAPS OF THE MESOSCALE ORGANIZATION OF FRONTO-PARIETAL CONNECTIONS. WE WILL BE POISED TO APPLY OUR MULTIMODAL, CROSS-SPECIES METHODS BRAIN-WIDE, INCLUDING BOTH CORTICAL AND SUBCORTICAL CIRCUITS. IMPORTANTLY, THE FOUNDATION WILL BE LAID FOR COMPUTING NONINVASIVE, IN VIVO, ACCURATE, MESOSCALE CONNECTIVITY MAPS OF WHOLE HUMAN BRAINS THROUGH DMRI TRACTOGRAPHY, WHICH WILL ALLOW RESEARCHERS TO LINK BRAIN CONNECTIVITY WITH COGNITION, BEHAVIOR, AND DISEASE.

INTEGRATED DEMOGRAPHIC AND HEALTH SERIES (IDHS)

COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND-GRANT INSTITUTIONS (SMITH-LEVER 3 (B) AND 3 (C) FORMULA) FY19 CAPACITY RFA

COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND-GRANT INSTITUTIONS (SMITH-LEVER 3 (B) AND 3 (C) FORMULA) FY19 CAPACITY RFA

** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THIS PROGRAM FUNDS RESEARCH AND EDUCATION/DEMONSTRATION PROJECTS AND PROVIDES TRAINING FOR AGRICULTURAL EDUCATORS AND ISINTENDED TO IMPROVE THE SUSTAINABILITY OF AGRICULTURE, ENCOURAGING PRACTICES THAT ARE PROFITABLE, CONSERVE OUR NATURAL RESOURCEBASE AND IMPROVE THE QUALITY OF LIFE FOR FARM FAMILIES AND THEIR COMMUNITIES.

COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND-GRANT INSTITUTIONS (SMITH-LEVER 3 (B) AND 3 (C) FORMULA) FY19 CAPACITY RFA

SPINAL MANIPULATION AND PATIENT SELF-MANAGEMENT TO PREVENT BACK PAIN CHRONICITY

CHARACTERIZING MECHANISTIC HETEROGENEITY ACROSS ADHD AND AUTISM

CANNABINOID-BASED THERAPY AND APPROACHES TO QUANTIFY PAIN IN SICKLE CELL DISEASE

INTEGRATED IMMUNE ENGINEERING FOR POOR PROGNOSIS CANCERS - ABSTRACT A KEY LIMITATION TO EFFECTIVE IMMUNOTHERAPY IS THE PHYSICAL ACCESS OF IMMUNE CELLS TO THE CANCER CELLS. WE PROPOSE TO DEVELOP A MULTISCALE TUMOR SIMULATOR TO PREDICT TUMOR DYNAMICS BASED ON IMMUNE AND CANCER CELL MIGRATION AND NET PROLIFERATION AS MEASURED QUANTITATIVELY FROM LIVE CELL MICROSCOPY. THE TUMOR SIMULATOR WILL BE DEVELOPED BY BIOMEDICAL ENGINEERS WORKING IN CLOSE COLLABORATION WITH IMMUNOLOGISTS AND GENETIC ENGINEERS WHO ARE DEVELOPING IMMUNOTHERAPIES FOR PANCREATIC DUCTAL ADENOCARCINOMA AND GLIOBLASTOMA. THE TUMOR SIMULATOR WILL BE A COMPUTATIONAL PLATFORM THAT WILL HELP GUIDE IMMUNOTHERAPY DEVELOPMENT AND SO WILL EVOLVE TO BECOME AN IMMUNOTHERAPY SIMULATOR. IN ADDITION, WE WILL INTEGRATE STATE- OF-THE-ART GENOME ENGINEERING AND MICROENVIRONMENTAL ENGINEERING TO BRING A FULL SUITE OF ENGINEERING APPROACHES TO BEAR ON THE SIMULATOR DEVELOPMENT. TOGETHER, THE SIMULATOR WILL BE USED TO MAKE QUANTITATIVE, TESTABLE PREDICTIONS THAT ARE THEN TESTED EXPERIMENTALLY USING PHARMACOLOGICAL AND GENETIC PERTURBATIONS. BY ITERATIVE MODEL DEVELOPMENT WE WILL TEST OUR CENTRAL HYPOTHESIS THAT IMMUNE CELL PROXIMITY IS A MAJOR DETERMINANT OF EFFECTIVE ANTI-TUMORAL IMMUNE RESPONSE, AND LIMITING TO EFFECTIVE IMMUNOTHERAPY OF SOLID TUMORS. ALTOGETHER, OUR PROGRAM PROJECT WILL DEVELOP A COMPREHENSIVE BIOPHYSICS-BASED SIMULATOR TO PREDICT TUMOR PROGRESSION AND ACCELERATE IMMUNOTHERAPY DEVELOPMENT.

MINNESOTA OBESITY CENTER

INTEGRATING, LINKING, AND DISSEMINATING CPS DATA, 1962 TO 2013

THE POLAR GEOSPATIAL CENTER: COMMUNITY AND FACILITY SUPPORT

COMMUNITY FACILITY SUPPORT: MANAGEMENT AND OPERATION OF A CONTINENTAL SCIENTIFIC DRILLING AND CORING FACILITY

COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND-GRANT INSTITUTIOS (SMITH-LEVER 3 (B) AND 3 (C) FORMULA) FY17 CAPACITY RFA

CIRCUIT-BASED DEEP BRAIN STIMULATION FOR PARKINSON'S DISEASE

COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND-GRANT INSTITUTIONS (SMITH-LEVER 3 (B) AND 3 (C) FORMULA) FY17 CAPACITY RFA

COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND-GRANT INSTITUTIONS (SMITH-LEVER 3(B) AND 3(C) FORMULA) FY14 CAPACITY RFA

MINNESOTA TISSUE MAPPING CENTER FOR SENESCENT CELLS - PROJECT SUMMARY SENESCENT CELLS (SNCS) ARE KNOWN TO PLAY A CAUSAL ROLE IN AGING AND NUMEROUS AGE-RELATED DISEASES. HOWEVER, THEY ALSO CONTRIBUTE TO WOUND HEALING AND TISSUE REMODELING. BOTH PHYSIOLOGICAL AND PATHOLOGICAL ROLES ARE LINKED TO THE SECRETOME OF SNCS AND THEIR COMPLEX INTERACTION WITH THE IMMUNE SYSTEM, WHICH IS THOUGHT TO PLAY AN IMPORTANT ROLE IN CLEARING SNCS. MOST OF WHAT WE HAVE LEARNED ABOUT SNCS IS DERIVED FROM MICE WHERE IT HAS BEEN CLEARLY DEMONSTRATED THAT GENETIC OR PHARMACOLOGIC REMOVAL OF SNCS IN AGED OR DISEASED ORGANISMS REDUCES FRAILTY; IMPROVES STRENGTH, ENDURANCE, AND RESILIENCE; AND ATTENUATES A VARIETY OF AGE-RELATED DISEASES INCLUDING ALZHEIMER’S. THIS NOVEL APPROACH OF THERAPEUTICALLY TARGETING A FUNDAMENTAL AGING PROCESS COMMON TO MANY DISEASES – RATHER THAN DRUGGING DISEASE-SPECIFIC PERTURBATIONS (E.G., LOW INSULIN OR HYPERTENSION) – COULD HAVE A TREMENDOUS IMPACT ON OUR AGING POPULATION. HOWEVER, MUCH NEEDS TO BE LEARNED ABOUT SNCS IN HUMANS TO DEPLOY SUCH APPROACHES SAFELY AND EFFECTIVELY. THIS PROJECT AIMS TO ESTABLISH A TISSUE MAPPING CENTER AT THE UNIVERSITY OF MINNESOTA (MN TMC) TO CONTRIBUTE TO THE SENNET CONSORTIUM, WHICH INTENDS TO BUILD A 4D ATLAS OF SNCS IN MULTIPLE HUMAN ORGANS WITH HEALTHY AGING. MN TMC PROPOSES TO FOCUS ON ADIPOSE (OMENTAL AND SUBCUTANEOUS), SKELETAL MUSCLE (VASTUS LATERALIS), LIVER, AND OVARIAN TISSUE. THIS SELECTION IS BASED ON MN TMC’S EXPERTISE IN THE BIOLOGY, CELL BIOLOGY, AND IMMUNOLOGY OF THESE ORGANS; IN STUDYING SNCS IN THESE ORGANS; AND EXPERIENCE WITH SINGLE CELL TECHNOLOGIES IN THESE ORGANS. THE MN TMC AND ITS ADMINISTRATIVE CORE WILL BE LED BY PIS WITH COMPLEMENTARY EXPERTISE IN SNCS AND COMPUTATIONAL BIOLOGY/HEALTH INFORMATICS. THE BIOSPECIMEN CORE WILL BE LED BY THE UMN CHAIRMAN OF SURGERY AND AN ACCOMPLISHED PATHOLOGIST. THE BIOLOGICAL ANALYSIS CORE WILL BE LED BY AN EXPERT IN SNC AND A MOLECULAR PATHOLOGIST LEADING SPATIAL GENOMICS AT UMN. THE DATA ANALYSIS CORE WILL BE LED BY THREE BIOINFORMATICIANS WITH EXPERTISE IN MODELING, SINGLE CELL, AND SPATIAL-OMICS ANALYSIS, AND BLENDING PATIENT ELECTRONIC HEALTH RECORDS WITH -OMICS DATA. A UNIQUE FEATURE OF THE PROPOSED MN TMC IS THAT THE ENTIRE WORKFLOW WILL BE HOUSED WITHIN EXISTING INFRASTRUCTURE/CORES: FROM CTSI AND BIONET, WHICH MANAGE HUMAN SUBJECTS RESEARCH, TISSUE PROCUREMENT, ANNOTATION, AND DISTRIBUTION/STORAGE, TO THE GENOMIC/ PROTEOMICS/IMAGING CORES, ALONG WITH THE INSTITUTE OF HEALTH INFORMATICS FOR DATA MANAGEMENT AND MULTIPLEXING. KEY PERSONNEL INCLUDE LEADERSHIP OF ALL OF THESE UMN COMPONENTS. THIS APPROACH PROVIDES UNEQUALED STABILITY OF OUR ANALYTICAL PIPELINE AND IN-PLACE QUALITY CONTROL AND ASSURANCE MECHANISMS. A SECOND UNIQUE FEATURE OF THE PROPOSED MN TMC IS OUR ABILITY TO PERFORM SPATIAL TRANSCRIPTOMICS AND PROTEOMICS ON FORMALIN-FIXED PARAFFIN EMBEDDED BIOSPECIMENS, WHICH ENABLES ANALYSIS OF THE MOST STABLE BIOSPECIMENS AND VIRTUALLY ANY ARCHIVED MATERIAL. OVERALL, THE GOAL OF THE MN TMC IS TO MAKE A SIGNIFICANT CONTRIBUTION TO THE 4D ATLAS OF HUMAN SNCS, WORKING CLOSELY WITH NIH AND OTHER TMCS TO DEVELOP AND ADHERE TO STANDARDS CREATED BY THE SENNET CONSORTIUM.

UNIVERSITY OF MINNESOTA CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE (UMN CTSI)

CONTROL OF MULTI-FUEL CAPABLE ENGINE FOR UAS, SUBMITTED ENERGY-EFFICIENT ENGINE AND DRIVETRAIN TECHNOLOGIES, VI. INNOVATIVE ENGINE TECHNOLOGIES

COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND-GRANT INSTITUTIONS FY2012 FORMULA GRANT OPPORTUNITY - FINAL

NATIONAL CENTER FOR FOOD PROTECTION AND DEFENSE

SRN: INTEGRATED URBAN INFRASTRUCTURE SOLUTIONS FOR ENVIRONMENTALLY SUSTAINABLE, HEALTHY AND LIVABLE CITIES.

TRAINING IN LUNG SCIENCE

TECHNICAL ASSISTANCE AND DISSEMINATION TO IMPROVE SERVICES AND RESULTS FOR CHILDREN WITH DISABILITIES AND TECHNICAL ASSISTANCE ON STATE DATA COLLECTION—NATIONAL ASSESSMENT CENTER (NAC)

NMR IMAGING AND SPECTROSCOPY

NEUROPHYSIOLOGICAL MECHANISMS UNDERLYING PARKINSONIAN MOTOR SIGNS

THE GENETIC BASIS OF MID-HINDBRAIN MALFORMATIONS

**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THIS PROGRAM FUNDS RESEARCH AND EDUCATION/DEMONSTRATION PROJECTS AND PROVIDES TRAINING FOR AGRICULTURAL EDUCATORS AND ISINTENDED TO IMPROVE THE SUSTAINABILITY OF AGRICULTURE, ENCOURAGING PRACTICES THAT ARE PROFITABLE, CONSERVE OUR NATURAL RESOURCEBASE AND IMPROVE THE QUALITY OF LIFE FOR FARM FAMILIES AND THEIR COMMUNITIES.

IPF FIBROBLAST PHENOTYPE

THIS PROGRAM FUNDS RESEARCH AND EDUCATION/DEMONSTRATION PROJECTS AND PROVIDES TRAINING FOR AGRICULTURAL EDUCATORS AND ISINTENDED TO IMPROVE THE SUSTAINABILITY OF AGRICULTURE, ENCOURAGING PRACTICES THAT ARE PROFITABLE, CONSERVE OUR NATURAL RESOURCEBASE AND IMPROVE THE QUALITY OF LIFE FOR FARM FAMILIES AND THEIR COMMUNITIES.

CANCER BIOLOGY TRAINING GRANT

THE PHIT WORKFORCE DEVELOPMENT PROGRAM

DATANET FULL PROPOSAL: TERRA POPULUS: A GLOBAL POPULATION/ENVIRONMENT DATA NETWORK

THE ROLE OF SENESCENT CELLS IN DYSREGULATING IMMUNE RESPONSES AND PATHOGEN CONTROL - SUMMARY THE ASSOCIATION BETWEEN ADVANCED AGE AND IMPAIRED RESISTANCE TO INFECTIONS IS WELL KNOWN, BUT POORLY UNDERSTOOD. THE CURRENT COVID-19 PANDEMIC IS A CLEAR EXAMPLE OF THE VULNERABILITY OF THE ELDERLY TO SARS- COV-2 INFECTION AS WELL AS MANY OTHER PATHOGENS. CONSIDERABLE RESEARCH EFFORTS HAVE SHOWN THAT COMPONENTS OF BOTH THE INNATE AND ADAPTIVE IMMUNE SYSTEMS SHOW SIGNS OF DYSFUNCTION AS WE AGE, WITH SIGNS OF BOTH IMMUNODEFICIENCY, INCLUDING REDUCED INNATE RESPONSE AND POOR INDUCTION OF ADAPTIVE IMMUNE MEMORY, AND IMMUNOPATHOLOGY INCLUDING AN EXAGGERATED “CYTOKINE STORM”. HOWEVER, WHILE ASPECTS OF AGE-RELATED CHANGES IN IMMUNE CELLS HAVE BEEN EXPLORED IN DEPTH, THE FOCUS HAS BEEN ON DEFINING THE NATURE OF DYSFUNCTION WITHIN CELLS OF THE IMMUNE SYSTEM ITSELF, RATHER THAN INVESTIGATING THE POTENTIAL ROLE OF OTHER CELL POPULATIONS IN DOMINANTLY COMPROMISING IMMUNE HOMEOSTASIS AND IMMUNOLOGICAL RESPONSE TO PATHOGENS. ALSO, ALTHOUGH THE INCREASE IN IMMUNOSENESCENCE WITH AGE, DEFINED BY CELL SURFACE MARKERS FOR IMMUNE CELL EXHAUSTION, HAS BEEN EXAMINED, THE EXTENT OF CELLULAR SENESCENCE IN IMMUNE CELL POPULATIONS WITH AGE AND PATHOGEN EXPOSURE REMAINS UNDEFINED. OUR RECENT FINDINGS INDICATE THAT SENESCENT CELLS (SNCS), INCLUDING SENESCENT IMMUNE CELLS, CAN EXERT A “BYSTANDER” EFFECT ON IMMUNE CELLS, PROVOKING IMMUNOLOGICAL DYSFUNCTION THROUGH SECRETION OF INFLAMMATORY FACTORS, INCLUDING CYTOKINES AND CHEMOKINES, TERMED THE “SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE” (SASP). WE DEMONSTRATED THAT SASP FACTOR PRODUCTION IS INCREASED WHEN SNCS OR MICE CONTAINING SNCS ARE EXPOSED TO PATHOGENS OR MICROBIAL PRODUCTS THAT INDUCE INNATE IMMUNE ACTIVATION. EXPOSURE OF OLD MICE TO NORMAL MICROBIAL EXPERIENCE (NME) HOUSING RESULTED IN 100% MORTALITY COMPARED TO NO MORTALITY IN YOUNG MICE. HOWEVER, REDUCING THE SENESCENT CELL BURDEN IN AGED MICE BEFORE OR FOLLOWING PATHOGEN EXPOSURE REDUCED THE SPREAD OF SENESCENCE, THE CYTOKINE STORM AND OVERALL MORTALITY. THESE RESULTS SUGGESTS THAT SNCS, ACTING AT LEAST IN PART THROUGH SASP FACTORS, CAN INCREASE PERIPHERAL SENESCENCE AND IMMUNE DYSFUNCTION FOLLOWING PATHOGEN EXPOSURE. MOREOVER, VIRAL INFECTION ITSELF DRIVES SENESCENCE, TERMED VIRUS INDUCED SENESCENCE, IN MICE AND HUMANS. USING MOUSE MODELS IN WHICH CELLULAR SENESCENCE IS INDUCED SPECIFICALLY IN IMMUNE CELLS, WE ALSO DEMONSTRATED THAT SENESCENT IMMUNE CELLS DRIVE IMMUNOLOGICAL DYSFUNCTION AND SECONDARY SENESCENCE AND PATHOLOGY IN NON-LYMPHOID TISSUES. THUS, OUR OVERARCHING HYPOTHESIS IS THAT SENESCENT CELLS, INCLUDING SENESCENT IMMUNE CELL TYPES, DOMINANTLY COMPROMISE INNATE AND ADAPTIVE IMMUNE CELL HOMEOSTASIS IN BOTH LYMPHOID AND NON-LYMPHOID ORGANS AND REACTIVITY TO PATHOGENS. IMPORTANTLY, WE ALSO HYPOTHESIZE THAT THESE ADVERSE EFFECTS CAN BE REVERSED BY SNC ELIMINATION WITH SENOLYTICS, PROVIDING A NEW THERAPEUTIC STRATEGY TO RESTORING IMMUNE FUNCTION IN THE AGED. WE PROPOSE TO TEST THESE HYPOTHESES IN OUR PPG APPLICATION ENTITLED “THE ROLE OF SENESCENT CELLS IN DYSREGULATING IMMUNE RESPONSES AND PATHOGEN CONTROL”, CONSISTING OF THREE COLLABORATIVE PROJECTS AND THREE INTEGRATED CORES.

UNIV OF MINNESOTA BUIDLING INTERDISCIPLINARY RESEARCH CAREERS IN WOMEN'S HEALTH

COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND-GRANT INSTITUTIONS FY2013 FORMULA GRANT OPPORTUNITY - FINAL

LOOK AHEAD: ACTION FOR HEALTH IN DIABETES

**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** WINTER STRESSES HAVE LONG BEEN A CHALLENGE FOR PROFESSIONAL TURFGRASS MANAGERS. THE LONG TERM GOAL OF THIS PROJECT IS TO BETTER UNDERSTAND TURFGRASS WINTER STRESSES AND THEN IDENTIFY SOLUTIONS TO THIS IMPORTANT SPECIALTY CROP PROBLEM. OUR APPROACH WILL INCLUDE RESEARCH IN PLANT BREEDING, GENETICS, AND PHYSIOLOGY; EFFORTS TO IMPROVE RESISTANCE TO PLANT DISEASE AND THEREBY REDUCE PESTICIDE APPLICATIONS; NEW TECHNOLOGICAL INNOVATIONS TO PREDICT WINTER STRESS DAMAGE MORE PRECISELY; AND MODERN APPROACHES TO ENGAGE AND EDUCATE STAKEHOLDERS. IN OUR FIRST OBJECTIVE, WE WILL MONITOR TURFGRASS STANDS IN COLD CLIMATES TO GAIN KNOWLEDGE ABOUT THE PROCESSES THAT LEAD TO WINTER DAMAGE AND HOW A CHANGING CLIMATE WILL BRING NEW CHALLENGES; WE WILL THEN USE THIS INFORMATION TO BOTH INFORM RESEARCH AND CREATE A WEB-BASED WINTER STRESS INJURY PREDICTION APPLICATION. IN OBJECTIVE 2, WE WILL INCREASE BASIC UNDERSTANDING OF TURFGRASS INJURY DUE TO ICE COVER AND FREEZE/THAW EVENTS. NEXT, IN OBJECTIVE 3, WE WILL DEEPEN OUR UNDERSTANDING OF SNOW MOLD PATHOGENS AND DEVELOP ALTERNATIVE, NON-FUNGICIDAL STRATEGIES FOR THEIR CONTROL IN MANAGED TURF. BREEDING AND GENETICS EFFORTS IN OBJECTIVE 4 WILL FOCUS ON GERMPLASM IMPROVEMENT FOR WINTER STRESS TOLERANCE. IN OBJECTIVE 5, WE WILL DEVELOP STRATEGIES FOR MITIGATION AND RECOVERY FROM WINTER STRESS DAMAGE AND INVESTIGATE THE ECONOMIC EFFECTS OF WINTER STRESS DAMAGE. FINALLY, IN OBJECTIVE 6, WE WILL COORDINATE A COMPREHENSIVE OUTREACH EFFORT DESIGNED TO EDUCATE MULTIPLE AUDIENCES AND IMPLEMENT RESEARCH RECOMMENDATIONS. WE AIM TO PROVIDE STAKEHOLDERS WITH SOLUTIONS TO COMBAT THE CHALLENGE OF WINTER STRESSES.

DESCRIPTION:THE THRIVING COMMUNITIES TECHNICAL ASSISTANCE CENTER WILL LEVERAGE EXISTING UNIVERSITY EXTENSION NETWORKS AND TECHNICAL SERVICE PROVIDERS TO REACH REMOTE, RURAL, AND UNDERSERVED COMMUNITIES ACROSS EPA REGION 5, INCLUDING THE STATES OF MINNESOTA, MICHIGAN, WISCONSIN, ILLINOIS, INDIANA, AND OHIO AND 35 TRIBAL NATIONS.ACTIVITIES:THE PROPOSED GREAT LAKES ENVIRONMENTAL JUSTICE TECHNICAL ASSISTANCE CENTER (TAC) IS ORIENTED AROUND THREE INTERRELATED ACTIVITIES: 1. IDENTIFY UNDERSERVED AND OVERBURDENED COMMUNITIES WHO COULD BENEFIT FROM ENVIRONMENTAL AND ENERGY-RELATED PROGRAMS, 2. BUILD CAPACITY FOR COMMUNITIES TO ENGAGE IN ENVIRONMENTAL DECISION MAKING AND ACCESS TECHNICAL ASSISTANCE, AND 3. PROVIDE TAILORED, ACCESSIBLE, CULTURALLY APPROPRIATE ASSISTANCE THAT ALLOWS COMMUNITIES TO SECURE FUNDING AND RESOURCES THAT MATERIALLY IMPROVE THEIR SOCIAL, ECONOMIC, AND ENVIRONMENTAL OUTCOMES.SUBRECIPIENT:ACTIVITIES INCLUDE PROVIDING TECHNICAL ASSISTANCE TO REGION 5 COMMUNITIES AND INDIVIDUALS, RUNNING WORKSHOPS, COMMUNICATING ABOUT FUNDING OPPORTUNITIES, AND OTHER RELATED ACTIVITIES. OUTCOMES:THE ANTICIPATED DELIVERABLES FOR THE TCTAC INCLUDE: A WEB PORTAL, MINUTES AND TRAININGS RELATED TO COMMUNITY WORKSHOPS, RECORDS OF APPLICANTS ASSISTED, AND OTHER RELATED MATERIALS. EXPECTED OUTCOMES INCLUDE: 1. HIGHER CAPACITY FOR COMMUNITIES, NON-PROFIT ORGANIZATIONS, AND INDIVIDUALS TO APPLY FOR GRANT OPPORTUNITIES, 2. IMPROVED CONNECTIONS BETWEEN COMMUNITIES AND TECHNICAL ASSISTANCE RESOURCES, AND 3. INCREASED PARTICIPATION IN FEDERAL AND STATE ENVIRONMENTAL AND ENERGY DECISION-MAKING AS EVIDENCED BY GREATER PARTICIPATION IN PUBLIC ENGAGEMENT, OUTREACH, EPA AND DOE PROGRAMS, PUBLIC COMMENTS, AND EJ COMMUNITIES OCCUPYING POSITIONS OF POWER IN LOCAL AND FEDERAL DECISION-MAKING BODIES. THE INTENDED BENEFICIARIES ARE THE PEOPLE OF REGION 5, INCLUDING THE RESIDENTS OF MINNESOTA, WISCONSIN, MICHIGAN, ILLINOIS, INDIANA, AND OHIO, AS WELL AS THE MEMBERS OF THE 35 FEDERALLY-RECOGNIZED TRIBES PRESENT IN THE REGION.

ENGRTEAMS: ENGINEERING TO TRANSFORM THE EDUCATION OF ANALYSIS, MEASUREMENT, AND SCIENCE IN A TEAM-BASED TARGETED MATHEMATICS-SCIENCE PARTNERSHIP

INTEGRATED MATERIALS PLATFORM FOR TOPOLOGICAL QUANTUM COMPUTING DEVICES

ADDRESSING ALZHEIMER'S DISEASE AND RELATED DEMENTIAS DISPARITIES: THE AMERICAN INDIGENOUS COGNITIVE ASSESSMENT (AMICA) PROJECT - THE ADDRESSING ALZHEIMER’S DISEASE AND RELATED DEMENTIAS DISPARITIES: THE AMERICAN INDIGENOUS COGNITIVE ASSESSMENT (AMICA) PROJECT TACKLES THE SIGNIFICANT DEMENTIA DISPARITY THAT EXISTS FOR INDIGENOUS POPULATIONS BY DETERMINING THE SCALABILITY OF RECENTLY DEVELOPED, CULTURALLY TAILORED, BRIEF COGNITIVE TESTS FOR DEMENTIA FOR USE IN DIVERSE AMERICAN INDIAN (AI) POPULATIONS. COMPARED TO THE MAJORITY POPULATION, INDIGENOUS RATES OF ALZHEIMER’S DISEASE AND RELATED DEMENTIAS (ADRD) ARE APPROXIMATELY 3 TIMES HIGHER. THIS RESEARCH WILL ADAPT AND VALIDATE A BATTERY OF COMPLEMENTARY INDIGENOUS COGNITIVE ASSESSMENT TOOLS DEVELOPED IN CANADA AND AUSTRALIA FOR USE AMONG AI POPULATIONS IN THE UNITED STATES. THIS BATTERY EXPANDS AND ADAPTS THE CANADIAN INDIGENOUS COGNITIVE ASSESSMENT (CICA), AS WELL AS THE AUSTRALIAN KIMBERLEY INDIGENOUS ASSESSMENTS FOR DEPRESSION (KICA DEPRESSION), ACTIVITIES OF DAILY LIVING (KICA-ADL) AND A CAREGIVER REPORT (KICA-CARER). CULTURE AND CONTEXT ARE CENTRAL TO INDIGENOUS PEOPLES’ EXPERIENCE WITH DEMENTIA AND DEMENTIA DIAGNOSIS. DUE TO SIGNIFICANT CULTURAL DIFFERENCES BETWEEN TRIBAL POPULATIONS IN AUSTRALIA, CANADA, AND THE US, EXISTING INDIGENOUS CULTURALLY VALID CLINICAL TOOLS CANNOT BE USED IN THE US UNTIL THEY ARE FIRST ADAPTED AND RE-VALIDATED. UNTIL UNBIASED TOOLS ARE DEVELOPED, WE RUN THE RISK OF BASING CRITICAL CLINICAL AND POLICY DECISIONS ON FLAWED EPIDEMIOLOGICAL ESTIMATES OF ADRD WHICH, IN TURN, FURTHER EXACERBATES DEMENTIA INEQUITIES. USING COMMUNITY- BASED PARTICIPATORY RESEARCH APPROACHES BLENDED WITH INDIGENOUS METHODOLOGIES, WE WILL REVISE EXISTING INDIGENOUS ASSESSMENTS TO ALIGN WITH AI CULTURAL CONTEXT AS WELL AS THE NEUROPSYCHIATRIC PROPERTIES. WE INTEND TO MEASURE AND ASSESS THE RELIABILITY, VALIDITY, AND CULTURAL ACCEPTANCE OF THE ADAPTED INSTRUMENTS WITH A TOTAL OF 390 DYADS OF PEOPLE WITH DEMENTIA AND THEIR CAREGIVERS (N=780) IN IN TWO CULTURALLY DISTINCT TRIBAL COMMUNITIES IN MINNESOTA, WISCONSIN, AND AN URBAN AI POPULATION IN NEW MEXICO. OUR CENTRAL HYPOTHESIS IS THAT DEVELOPING A CULTURALLY SAFE COGNITIVE ASSESSMENT APPROACH THAT ACCOUNTS FOR CULTURAL CONTEXT WILL PROVIDE ACCURATE DIAGNOSES, WHICH IN TURN WILL HELP US ACHIEVE OUR LONG-TERM GOAL OF IMPROVING THE DIAGNOSIS AND CARE OF INDIGENOUS PERSONS WITH DEMENTIA ACROSS THE ADRD CONTINUUM. OUR SPECIFIC AIMS ARE TO: 1) CREATE AMERICAN INDIAN APPROPRIATE VERSIONS OF THE CICA COG, KICA CARER, KICA DEPRESSION AND KICA-ADL (THE “AMICA BATTERY”); 2) ASSESS THE PSYCHOMETRIC PROPERTIES AND CULTURAL ACCEPTABILITY OF THE FOUR TOOLS IN THE AMICA BATTERY. WE HYPOTHESIZE THAT THE AMICA BATTERY WILL DEMONSTRATE STRONG RELIABILITY, VALIDITY, SENSITIVITY, SPECIFICITY, POSITIVE AND NEGATIVE PREDICTIVE VALUE RELATIVE TO THE TWO-EYED SEEING CONSENSUS DIAGNOSIS. THUS THE AMICA BATTERY WILL PRODUCE THE SAME DIAGNOSES, WHILE PROVIDING GREATER CULTURAL SAFETY, THAN THE STANDARD ASSESSMENTS. BY ACHIEVING THESE AIMS WE CAN EXPECT TO DELIVER THE FIRST CULTURALLY ADAPTED VALID COGNITIVE ASSESSMENT BATTERY FOR AMERICAN INDIAN OLDER ADULTS. IN DOING SO, THIS RESEARCH WILL HELP TO REDUCE DISPARITIES, ACCELERATE RESEARCH, AND ENHANCE ACCESS TO HIGH QUALITY CLINICAL PRACTICE.

TAS::89 0331::TAS RECOVERY RECOVERY ACT: AN INDUSTRY/ACADEME CONSORTIUM FOR ACHIEVING 20% WIND BY 2030 THROUGH CUTTING-EDGE RESEARCH AND WORKFORC

PREVENTION OF LOWER URINARY TRACT SYMPTOMS IN WOMEN: BLADDER HEALTH SCIENTIFIC AND DATA COORDINATING CENTER (PLUS-SDCC) (U01)

THE CONTRIBUTIONS OF PERSONALITY AND SOCIAL RELATIONSHIPS TO LATE-LIFE HEALTH: A TWIN STUDY APPROACH

STRATEGIES TO OPTIMIZE PIG-TO PRIMATE KIDNEY XENOGRAFT SURVIVAL - WITH OVER 100,000 PATIENTS NOW ON THE WAITING LIST FOR A KIDNEY TRANSPLANT, IT IS OBVIOUS THAT THERE IS A CRITICAL SHORTAGE OF AVAILABLE DONOR ORGANS. XENOTRANSPLANTATION REPRESENTS A PROMISING SOLUTION. WHILE PIGS ARE VIEWED AS THE OPTIMAL NON-HUMAN SOURCE OF ORGANS, THE POTENCY OF THE HUMAN IMMUNE RESPONSE TO PIG ORGANS HAS PREVENTED THE CLINICAL APPLICATION OF PIG-TO-HUMAN KIDNEY TRANSPLANTATION. IN THIS APPLICATION WE PROPOSE USING CUTTING-EDGE GENETIC ENGINEERING APPROACHES IN COMBINATION WITH NOVEL, CLINICALLY RELEVANT IMMUNE- SUPPRESSANTS TO REDUCE BOTH THE HUMORAL AND CELLULAR IMMUNE RESPONSE OF NONHUMAN PRIMATES UNDERGOING KIDNEY XENOTRANSPLANTATION AS A PRECLINICAL MODEL TO INFORM FUTURE HUMAN TRIALS. WITH RECENT ADVANCES IN GENOME EDITING TECHNIQUES WE AND OTHERS HAVE CREATED NOVEL PIG DONORS WITH MULTIPLE GENETIC ALTERATIONS AND RESULTANT IMPROVEMENTS IN XENOGRAFT SURVIVAL. IN ADDITION, WE HAVE DEVELOPED AND APPLIED STRATEGIES TO AVOID EARLY ANTIBODY MEDIATED REJECTION BY USING A PRE-TRANSPLANT ANTIBODY SCREEN SIMILAR TO THE CROSSMATCH USED IN CLINICAL TRANSPLANTATION. WE FURTHER IDENTIFIED CD4+ T CELLS AS A CRITICAL SUBSET IN XENOGRAFT REJECTION AND DEMONSTRATED CONSISTENT LONG-TERM SURVIVAL IN THE PIG-TO-PRIMATE KIDNEY TRANSPLANT MODEL. THESE RESULTS REPRESENT A MAJOR ADVANCE ON THE ROAD TO CLINICAL TRANSLATION OF XENOTRANSPLANTATION. HERE WE PROPOSE TO STUDY THREE MAJOR BARRIERS TO THE CLINICAL TRANSLATION OF XENOTRANSPLANTATION: (1) ALL LONG-TERM XENOGRAFT SURVIVAL HAS BEEN DEPENDENT ON ANTIBODY BLOCKADE OF THE CD40-CD154 PATHWAY AND THERE IS CURRENTLY NO CLINICALLY APPROVED REAGENT. WE WILL EVALUATE THE ONLY TWO CLINICALLY RELEVANT CD40-CD154 PATHWAY ANTAGONISTS THAT ARE IN DEVELOPMENT AND HAVE SHOWN EFFICACY IN HUMAN PATIENTS: A) ISCALIMAB, A NOVEL ANTI-CD40 ANTIBODY AND B) VIB4920, AN INNOVATIVE CD154-TARGETING PROTEIN. NEITHER OF THESE NEW REAGENTS HAS BEEN TESTED IN XENOTRANSPLANTATION PREVIOUSLY. (2) WE WILL DETERMINE THE IMPACT OF TWO NOVEL DESENSITIZATION TREATMENTS AS WELL AS TRANSIENT COMPLEMENT INHIBITION ON EARLY ANTIBODY MEDIATED REJECTION. WE WILL TEST IMLIFIDASE (IDES, AN IGG DEGRADING ENZYME RECENTLY APPROVED BY THE FDA FOR THE PREVENTION AND TREATMENT OF ANTIBODY MEDIATED REJECTION) AS WELL AS AN INNOVATIVE DESENSITIZATION STRATEGY COMBINING COSTIMULATION BLOCKADE AND PROTEASOME INHIBITION. IN ADDITION TO ADDRESSING EARLY ANTIBODY MEDIATED INJURY WE WILL TEST A NOVEL COMPLEMENT-DIRECTED THERAPY, TESIDOLUMAB, AN ANTI-C5 ANTIBODY THAT IS CURRENTLY BEING EVALUATED IN CLINICAL TRIALS. WE PRESENT EXCITING DATA USING THE NOVEL ANTI-C5 ANTIBODY TESIDOLUMAB, SUGGESTING THAT TARGETED COMPLEMENT INHIBITION MITIGATES EARLY ANTIBODY REJECTION. (3) LASTLY WE WILL ADDRESS THE IMPORTANT ISSUE OF LATE ANTIBODY MEDIATED INJURY. GIVEN OUR SUCCESS WE ARE UNIQUELY POSITIONED TO STUDY THIS IMPORTANT PROBLEM. SIMILAR TO CLINICAL KIDNEY TRANSPLANTATION, WE HAVE NEW DATA THAT LATE KIDNEY XENOGRAFT INJURY IS DIRECTLY RELATED TO THE DEVELOPMENT OF ANTI-SLA CLASS II ANTIBODY. WE WILL TEST THE IMPORTANCE OF THIS FINDING BY DELETING THE GENES FOR SLA CLASS II DQ AND DR IN THE PORCINE DONOR TISSUE AND ASSESSING THE IMPACT ON REJECTION AND PROTECTIVE IMMUNITY.

CRITICAL NEED AND RATIONALE: IN THE U.S., POTATOES ARE GROWN ON OVER 1 MILLION ACRES IN 30 STATES WITH A FARM-GATE VALUE OF APPROXIMATELY $4 BILLION. THE TOP NINE PRODUCING STATES (IDAHO, WASHINGTON, OREGON, NORTH DAKOTA, MINNESOTA, WISCONSIN, MICHIGAN, MAINE AND COLORADO) COMPRISE FOUR MAJOR U.S. GROWING REGIONS (PACIFIC NORTHWEST, UPPER MIDWEST, NORTHEAST, AND SOUTHWEST). SOIL HEALTH IS A TERM USED TO IDENTIFY THE CONDITION OF A SOIL TO FUNCTION AS A VITAL LIVING ECOSYSTEM THAT SUSTAINS PLANTS, ANIMALS AND HUMANS. A MAJOR FOCUS OF SOIL HEALTH IS ON MAINTAINING AND ENHANCING SOIL ORGANIC MATTER AND A BENEFICIAL SOIL MICROBIAL COMMUNITY. SOILBORNE DISEASES IN POTATO PRODUCTION REPRESENT A MAJOR CHALLENGE TO THE POTATO INDUSTRY OFTEN REQUIRING FUMIGATION FOR THEIR CONTROL. INCREASING EVIDENCE EXISTS THAT INCORPORATING PRACTICES TO IMPROVE SOIL HEALTH MAY BE A SUSTAINABLE OPTION FOR MITIGATING THE EFFECTS OF SOILBORNE DISEASES. HOWEVER, ENHANCING SOIL HEALTH IN POTATO CROPPING SYSTEMS IS A CHALLENGE BECAUSE OF THE SIGNIFICANT SOIL DISTURBANCE THAT OCCURS DURING POTATO PLANTING AND HARVEST, LACK OF ORGANIC RESIDUE ASSOCIATED WITH POTATO VINES, DIFFICULTY IN ESTABLISHING A COVER CROP FOLLOWING HARVEST IN SOME REGIONS, AND THE NEED TO RELY ON FUMIGATION TO CONTROL DISEASES. THIS PROJECT WILL ADDRESS SIGNIFICANT KNOWLEDGE GAPS RELATED TO THE COMPLEX RELATIONSHIPS AMONG FACTORS AFFECTING SOIL HEALTH AND POTATO SOILBORNE DISEASES. OUR STUDIES WILL CONSIDER THE ENTIRE POTATO CROPPING SYSTEM, INCLUDING POTATO CULTIVAR, ROTATION CROPS, BIOLOGICAL CONTROL OPTIONS, AND COVER CROPS TO IDENTIFY MANAGEMENT PRACTICES THAT ENHANCE SOIL HEALTH AND REDUCE SOILBORNE DISEASES AND TO IDENTIFY INDICATORS OF SOIL HEALTH ASSOCIATED WITH THOSE PRACTICES ACROSS THE MAJOR U.S. POTATO PRODUCTION AREAS. THE OVERALL RESULT WILL BE TO ENHANCE ENVIRONMENTAL QUALITY AND TO SUSTAIN THE ECONOMIC VIABILITY OF POTATO OPERATIONS IN THE U.S.METHODS, APPROACHES AND EXPECTED ACCOMPLISHMENTS: THIS PROJECT INVOLVES A TEAM OF 24 COLLABORATORS CONSISTING OF SOIL SCIENTISTS, PLANT PATHOLOGISTS, POTATO AGRONOMISTS, AND SOCIAL SCIENTISTS. FIELD EXPERIMENTS WITH DEFINED POTATO ROTATIONS WILL BE ESTABLISHED TO EVALUATE THE EFFECTS OF POTATO CULTIVAR, FUMIGATION, CROP ROTATION, COVER CROPS, GREEN MANURES, MICROBIAL INOCULANTS, AND NUTRIENT AMENDMENTS ON BIOLOGICAL, CHEMICAL AND PHYSICAL SOIL HEALTH INDICATORS, AS WELL AS ON POTATO HEALTH AND YIELDS. NEXT GENERATION SEQUENCING DNA ANALYSIS WILL BE USED TO IDENTIFY SOIL MICROBIAL COMMUNITIES ASSOCIATED WITH PRACTICES THAT ENHANCE SOIL HEALTH. AN ON-FARM NETWORK OF SITES THROUGHOUT MAJOR COMMERCIAL POTATO PRODUCTION AREAS WILL BE ESTABLISHED TO EVALUATE SPATIAL VARIABILITY OF SOIL HEALTH INDICATORS AND PLANT HEALTH/PRODUCTIVITY DATA. THIS INFORMATION WILL BE USED TO DEVELOP A SOIL HEALTH ASSESSMENT AND SOILBORNE PATHOGEN RISK-ADVISORY TOOL FOR PRECISION MANAGEMENT OF POTATO. THE NEXT STEP WILL BE TO IDENTIFY FACTORS AFFECTING ADOPTION OF PRACTICES AND TECHNOLOGIES THAT IMPROVE SOIL HEALTH IN POTATO PRODUCTION SYSTEMS. MONETARY AND NON-MONETARY INFORMATIONAL REQUIREMENTS NECESSARY FOR POTATO GROWERS TO ADOPT RECOMMENDED SOIL ENHANCEMENT PRACTICES WILL BE IDENTIFIED AND A MODEL TO IDENTIFY OPTIMAL CROP ROTATIONS WITH POTATOES WILL BE DEVELOPED. THE INFORMATION GENERATED WILL BE USED TO DEVELOP STATE, REGIONAL AND NATIONAL EXTENSION PROGRAMS IN POTATO SOIL HEALTH THAT WILL LEAD TO GREATER ADOPTION OF SUSTAINABLE MANAGEMENT PRACTICES. BY THE END OF THIS PROJECT, OUR VISION IS TO DEVELOP TWO REGIONAL MANUALS ON POTATO SOIL HEALTH (NORTHWEST/SOUTHWEST AND MIDWEST/EAST) THAT PROVIDE SOIL HEALTH INFORMATION APPROPRIATE FOR EACH REGION.

NEUROSCIENCE TRAINING IN DRUG ABUSE RESEARCH

TRAINING IN NEUROIMMUNE/NEUROBEHAVIOR ADDICTION RESEARCH

THIS PROGRAM FUNDS RESEARCH AND EDUCATION/DEMONSTRATION PROJECTS AND PROVIDES TRAINING FOR AGRICULTURAL EDUCATORS AND IS INTENDED TO IMPROVE THE SUSTAINABILITY OF AGRICULTURE, ENCOURAGING PRACTICES THAT ARE PROFITABLE, CONSERVE OUR NATURAL RESOURCE BASE AND IMPROVE THE QUALITY OF LIFE FOR FARM FAMILIES AND THEIR COMMUNITIES.

CONSOLE FOR 10.5 TESLA WHOLE BODY MRI SYSTEM

CENTER FOR INTERACTING GEO-PROCESSES IN MINERAL CARBON STORAGE

PHYSICS AT THE ENERGY FRONTIER: CMS AT THE LHC

ORGAN TRANSPLANTATION IN ANIMALS AND MAN

MIDWESTERN PROGENITOR CELL CONSORTIUM

UNIVERSITY TRANSPORTATION CENTER

LTER: MULTI-DECADAL RESPONSES OF PRAIRIE, SAVANNA, AND FOREST ECOSYSTEMS TO INTERACTING ENVIRONMENTAL CHANGES: INSIGHTS FROM EXPERIMENTS, OBSERVATIONS, AND MODELS

VASCULAR PATHOBIOLOGY OF SICKLE CELL DISEASE

IMPROVING DIAGNOSTICS AND NEUROCOGNITIVE OUTCOMES IN HIV/AIDS-RELATED MENINGITIS

PREVENTION OF LOWER URINARY TRACT SYMPTOMS (PLUS) RESEARCH CONSORTIUM SCIENTIFIC AND DATA COORDINATING CENTER

INDIGENOUS CULTURAL UNDERSTANDINGS OF ALZHEIMER'S DISEASE AND RELATED DEMENTIAS - RESEARCH AND ENGAGEMENT (I-CARE) - PROJECT SUMMARY/ABSTRACT THIS PROJECT, TITLED THE INDIGENOUS CULTURAL-UNDERSTANDINGS OF ALZHEIMER’S – RESEARCH AND ENGAGEMENT (ICARE) FOCUSES ON THE URGENT NEED TO ADDRESS THE INCREASING BURDEN OF ALZHEIMER’S DISEASE AND RELATED DEMENTIAS (ADRD) IN AMERICAN INDIAN (AI) AND FIRST NATIONS (FN) POPULATIONS. OUR CENTRAL HYPOTHESIS IS THAT CULTURE AND COMMUNITY-SPECIFIC CONTEXT SHAPE ADRD ILLNESS EXPERIENCES IN INDIGENOUS POPULATIONS SIGNIFICANTLY ENOUGH TO CREATE DISTINCT IMPACTS OF ADRD REQUIRING CULTURALLY TAILORED APPROACHES TO DIAGNOSIS, CARE AND EDUCATION. OUR GOAL IS TO CREATE A FOUNDATIONAL ETHNOGRAPHIC DATABASE OF AI/FN LIVED EXPERIENCE OF ADRD THAT CAN BE EXAMINED TO INFORM THE CREATION OF CULTURALLY APPROPRIATE AND SAFE APPROACHES TO IMPROVE DEMENTIA DIAGNOSTICS, CARE AND OUTREACH. OUR FINDINGS WILL INFORM OUR LONGER-TERM GOAL TO CREATE CULTURALLY SAFE CLINICAL GUIDELINES AND DEMENTIA DIAGNOSIS AND CARE TOOLS FOR NORTH AMERICAN INDIGENOUS POPULATIONS. AI/FN ADRD RATES ARE APPROXIMATELY THREE TIMES HIGHER, WITH A 10-YEAR EARLIER ONSET, COMPARED TO MAJORITY POPULATIONS. HIGHER RATES OF CO-MORBIDITIES AND LIMITED ACCESS TO SOCIAL, ECONOMIC, AND HEALTH RESOURCES INCREASE INDIGENOUS HEALTH DISPARITIES. CULTURE AND COMMUNITY CONTEXT INFLUENCE INDIGENOUS PEOPLES’ EXPERIENCE WITH DEMENTIA AND CULTURALLY GROUNDED APPROACHES/RESOURCES INCREASE AWARENESS AND IMPROVE OUTCOMES. CURRENTLY, THERE IS LITTLE INFORMATION TO GUIDE CULTURALLY APPROPRIATE EFFORTS TO ADDRESS ADRD. USING COMMUNITY-BASED PARTICIPATORY RESEARCH (CBPR), ICARE ENGAGES AI/FN COMMUNITIES IN MINNESOTA, WISCONSIN AND ONTARIO. WE WILL UNDERTAKE A CBPR QUALITATIVE ETHNOGRAPHIC EXAMINATION OF THE AI/FN LIVED EXPERIENCE ACROSS THE ILLNESS TRAJECTORY INCLUDING: CULTURAL UNDERSTANDINGS OF ADRD; EXPERIENCES WITH DIAGNOSIS AND CARE; AND AI/FN COMMUNITY STRENGTHS AND CHALLENGES. SPECIFIC METHODS INCLUDE PARTICIPANT OBSERVATION AND SEMI-STRUCTURED IN-DEPTH INTERVIEWS WITH PEOPLE WITH DEMENTIA (PWD), CAREGIVERS, AND HEALTHY SENIORS. OUR QUALITATIVE ANALYTIC APPROACH INCORPORATES BOTH BIOMEDICAL AND INDIGENOUS UNDERSTANDINGS OF ADRD. OUR RESEARCH HAS THREE SPECIFIC AIMS. FIRST, WE WILL DOCUMENT AND EXAMINE THE LIVED EXPERIENCES OF ADRD ACROSS THE DISEASE TRAJECTORY IN 3 DIVERSE AI/FN REGIONS (RED LAKE NATION AND GRAND PORTAGE, MN; ONEIDA NATION, WI; MANITOULIN ISLAND, ON) AND IDENTIFY CULTURAL, HEALTH SYSTEMS, AND COMMUNITY FACTORS INFLUENCING ADRD DIAGNOSTIC AND CARE PATHWAYS FOR PWD. SECOND, WE WILL USE THIS ETHNOGRAPHIC DATA TO DELINEATE AI/FN SPECIFIC EXPLANATORY MODELS OF ADRD AND UNDERSTANDINGS OF ADRD QUALITY OF LIFE, DIAGNOSIS AND STAGING TO IDENTIFY APPROPRIATE APPROACHES TO DIAGNOSE AND ASSESS ADRD IN AI/FN POPULATIONS. THIRD, WE WILL CONDUCT COLLABORATIVE KNOWLEDGE TRANSLATION OF ETHNOGRAPHIC KNOWLEDGE INTO CULTURALLY APPROPRIATE HEALTH PROMOTION/EDUCATION TOOLS (FACT SHEETS, VIDEOS OR TRAINING MODULES) TO RESPOND TO COMMUNITY NEEDS. THIS STUDY REPRESENTS AN IMPORTANT STEP IN IDENTIFYING EFFECTIVE, CULTURALLY-GROUNDED APPROACHES TO ADDRESS DEMENTIA- RELATED INEQUITIES IN AI/FN POPULATIONS.

PARTICULATE AND PRECIPITATION EFFECTS ON HIGH-SPEED FLIGHT VEHICLES

PREDICTING TURBULENT MULTI-PHASE FLOWS WITH HIGH FIDELITY: A PHYSICS-BASED APPROACH

ROLL-TO-ROLL, HIGH SPEED PRINTING OF MULTI-FUNCTIONAL, DISTRIBUTED SENSOR NETWORKS FOR ENHANCING THE BRAIN-MACHINE INTERFACE

RURAL HEALTH RESEARCH GRANT PROGRAM COOPERATIVE AGREEMENT

HEMATOLOGY RESEARCH TRAINING PROGRAM

CLINIC-BASED MULTICENTER ALS NATURAL HISTORY DATA COLLECTION - PROJECT SUMMARY/ABSTRACT AMYOTROPHIC LATERAL SCLEROSIS (ALS) IS A UNIVERSALLY DISABLING AND FATAL NEUROLOGICAL CONDITION. CURRENT TREATMENTS HAVE ONLY MODEST BENEFIT. DEVELOPMENT OF EFFECTIVE THERAPEUTICS IS HAMPERED IN PART BY INADEQUATE KNOWLEDGE OF ALS NATURAL HISTORY. THOUGH VALUABLE, EXISTING ALS REGISTRIES HAVE EITHER LARGE SAMPLES SIZES BUT LIMITED CLINICAL INFORMATION, FOCUS ON RELATIVELY SMALL SUBSETS OF THE ALS POPULATION, OR PROVIDE INFORMATION FROM A RELATIVELY BRIEF PERIOD. HOWEVER, AS A PART OF ROUTINE CLINICAL CARE, ALS MULTIDISCIPLINARY CLINICS (MDCS) DEVELOP A RICH NATURAL HISTORY DATASET FROM ALL ALS PATIENTS, AND MOST PEOPLE LIVING WITH ALS ARE SEEN AT MDCS. WE HAVE BUILT A COMBINED, DE-IDENTIFIED NATURAL HISTORY DATASET FROM OVER 1,700 ALS PATIENTS FROM 9 MDCS, WITH RACIAL REPRESENTATION THAT IS REFLECTIVE OF THE ALS POPULATION AT LARGE AND BROAD GEOGRAPHIC REPRESENTATION AS WELL. WE OFFER ENROLLMENT TO ALL PATIENTS AT OUR CLINICS. WE WILL BUILD ON OUR MULTICENTER, LONGITUDINAL, PROSPECTIVE MDC DATASET IN COLLABORATION WITH INDUSTRY AND THE ALS PATIENT COMMUNITY TO PROVIDE INFORMATION CRITICAL FOR CLINICAL TRIAL DEVELOPMENT AND POST-MARKETING EVALUATION. SPECIFICALLY, WE WILL DO THE FOLLOWING: RECORD CLINICALLY RELEVANT BASELINE CHARACTERISTICS AND SERUM NEUROFILAMENT LIGHT (NFL) MEASUREMENTS AT ENROLLMENT AS WELL AS VALIDATED LONGITUDINAL MEASURES OF DISEASE PROGRESSION INCLUDING ALSFRS-R AND DISEASE STAGING, RESPIRATORY VITAL CAPACITY, SPEAKING RATE AND 10 METER WALK TEST (AIM 1), RECORD DISEASE MILESTONES BASED UPON PATIENT-REPORTED OUTCOMES, DURABLE MEDICAL EQUIPMENT ORDERS IN THE ELECTRONIC HEALTH RECORD, AND OTHER EVENTS SUCH AS DATES OF GASTROSTOMY, HOSPITALIZATIONS, AND DEATH (AIM 2), AND MODEL TIME TO EVENTS USING BASELINE CHARACTERISTICS AS WELL AS RETROSPECTIVE AND PROSPECTIVE LONGITUDINAL DATA (AIM 3). WE HAVE DEMONSTRATED THE ABILITY TO ENROLL THE VAST MAJORITY OF PATIENTS SEEKING CARE IN OUR CLINICS SO AS TO BEST REPRESENT THE ALS POPULATION. BASELINE CHARACTERISTICS WILL INCLUDE ALS PHENOTYPE AND RESULTS OF GENETIC TESTING. DATASETS WILL BE MADE AVAILABLE TO ACADEMIC AND INDUSTRY INVESTIGATORS TO ADVANCE ALS CARE, DRUG DEVELOPMENT, AND OUTCOMES RESEARCH. WE WILL EXPAND EXISTING ENGAGEMENT FROM INDUSTRY AND OTHER STAKEHOLDERS TO INCLUDE AN ADVISORY PANEL OF PEOPLE LIVING WITH ALS AND WILL ENCOURAGE OPPORTUNITIES FOR DATA DISSEMINATION THROUGH THESE EXISTING RELATIONSHIPS AND PUBLICATIONS.

TRIAL FOR THE OPTIMAL TIMING OF HIV THERAPY AFTER CRYPTOCOCCAL MENINGITIS

COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND-GRANT INSTITUTIONS (SMITH-LEVER 3 (B) AND 3 (C) FORMULA) FY16 CAPACITY RFA

COOPERATIVE EXTENSION PROGRAMS AT 1862 LAND-GRANT INSTITUTIONS (SMITH-LEVER 3 (B) AND 3 (C) FORMULA) FY15 CAPACITY RFA

CYTOSKELETAL INTERACTIONS OF DYSTROPHIN

SCHOLAR DEVELOPMENT CLINICAL RESEARCH (RMI)

APPLICATION PURPOSE: THE MOBILITY ACCESS AND TRANSPORTATION INSECURITY PROGRAM WILL ESTABLISH AN INITIATIVE TO EXPLORE STRATEGIES TO IMPROVE PEOPLES MOBILITY AND ACCESS TO DAILY NEEDS AND EVALUATE OUTCOMES AND IMPACTS UPON INDIVIDUALS AND COMMUNITIES.; ACTIVITIES PERFORMED: ESTABLISHMENT OF A RESEARCH AND DEMONSTRATION PROGRAM TO EXPLORE INTERVENTIONS TO ENSURE MOBILITY ACCESS AND EVALUATE OUTCOMES. COLLECTION OF NEEDED DATA AND INPUT TO SET PERFORMANCE METRIC AND EVALUATION PLAN FOR DEMONSTRATION COMMUNITIES AND PROJECTS. SELECTION OF DEMONSTRATION SITES TO PILOT INTERVENTIONS. EVALUATION OF INTERVENTIONS PERFORMANCE AND SHARING OF FINAL RESULTS.; EXPECTED OUTCOMES: CREATION AND PILOTING OF TRANSPORTATION INTERVENTIONS THAT CAN SUPPORT AN EQUITABLE INTEGRATED TRANSPORTATION SYSTEM THAT MEETS TRANSPORTATION NEEDS FOR LOW-INCOME INDIVIDUALS AND/OR COMMUNITIES OF NEED. SET OF RESEARCH CONCLUSIONS AND EVALUATIONS OF THE PILOTED INTERVENTIONS.; INTENDED BENEFICIARIES: PEOPLE OR COMMUNITIES EXPERIENCING TRANSPORTATION INSECURITY OR CHALLENGES. DEMONSTRATION PROJECTS WILL FOCUS WORK ON SERVING POPULATIONS OF LOW-INCOME INDIVIDUALS AND/OR COMMUNITIES OF NEED IN URBAN AREAS ACROSS THE UNITED STATES; SUBRECIPIENT ACTIVITIES: TWO SUBRECIPIENTS WILL BE CONTRACTED MEMBERS OF THE PROJECT TEAM WORKING UNDER THE DIRECTION OF THE UNIVERSITY OF MINNESOTA. THESE SUBRECIPIENTS WILL HELP EXECUTE THE PROGRAM THROUGHOUT THE LIFE OF THE EFFORT. ACTIVITIES WILL INCLUDE DEMONSTRATION RECRUITMENT RESEARCH AND EVALUATION PARTNER COMMUNICATION AND SUPPORT AND DEMONSTRATION PROJECT GUIDANCE. 10 DEMONSTRATION SITE GROUPS WILL BE SELECTED IN A FIRST COMPETITIVE ROUND OF FUNDING TO DEVELOP POTENTIAL DEMONSTRATION INTERVENTIONS. DURING THIS ROUND ACTIVITIES WILL INCLUDE STAFFING FOR MANAGEMENT OUTREACH AND COMMUNICATIONS ENGAGEMENT PLANNING AND PROJECT DESIGN. OF THE INITIAL 10 FIVE DEMONSTRATION GROUPS WILL BE SELECTED FOR THE FULL DEPLOYMENT OF PLANNED INTERVENTIONS. ACTIVITIES IN THIS ROUND INCLUDE STAFFING AND MATERIALS NEEDED FOR MANAGEMENT OUTREACH AND COMMUNICATIONS PROJECT DEVELOPMENT AND DEPLOYMENT.

COSTAMERE DEFECTS IN MUSCULAR DYSTROPHIES

GCRC-GENERAL CLINICAL RESEARCH CENTER

TYPE 1 DIABETES-A PROPOSAL FOR PREVENTION & INTERVENTION

NATIONAL CENTER FOR FOOD PROTECTION AND DEFENSE

RENOVATION OF THE ST. ANTHONY FALLS LABORATORY-UNIVERSITY OF MINNESOTA FOR RESEARCH IN ENERGY AND ENVIRONMENTAL SUSTAINABILITY

TICK-MAMMAL INTERFACE OF HUMAN GRANULOCYTIC ANAPLASMOSIS

COMPLEX PITCH PERCEPTION IN COMPLEX ENVIRONMENTS

THE POLAR GEOSPATIAL INFORMATION CENTER: JOINT SUPPORT

DEVELOPMENT AND TRANSLATION OF AN INTRACRANIAL AUDITORY NERVE IMPLANT

TRAINING FOR FUTURE BIOTECHNOLOGY DEVELOPMENT

LIPID AND PROTEIN EFFECTS ON MONOLAYER STABILITY

CAENORHABDITIS GENETICS CENTER

17/24 HEALTHY BRAIN AND CHILD DEVELOPMENT NATIONAL CONSORTIUM - PROJECT SUMMARY/ABSTRACT NEURODEVELOPMENTAL PROCESSES ARE SHAPED BY DYNAMIC INTERACTIONS BETWEEN GENES AND ENVIRONMENTS. MALADAPTIVE EXPERIENCES EARLY IN LIFE CAN ALTER DEVELOPMENTAL TRAJECTORIES, LEADING TO HARMFUL AND ENDURING DEVELOPMENTAL SEQUELAE. PRE- AND POSTNATAL HAZARDS INCLUDE MATERNAL SUBSTANCE EXPOSURE, TOXICANT EXPOSURES IN PREGNANCY AND EARLY LIFE, MATERNAL HEALTH CONDITIONS, PARENTAL PSYCHOPATHOLOGY, MALTREATMENT, STRUCTURAL RACISM, AND EXCESSIVE STRESS. TO ELUCIDATE HOW VARIOUS ENVIRONMENTAL HAZARDS IMPACT CHILD DEVELOPMENT, IT IS IMPERATIVE THAT A NORMATIVE TEMPLATE OF DEVELOPMENTAL TRAJECTORIES OVER THE FIRST 10 YEARS OF LIFE BE ESTABLISHED BASED ON A SUFFICIENTLY LARGE AND DEMOGRAPHICALLY DIVERSE SAMPLE OF THE US POPULATION. TO ACCOMPLISH THIS, THE HEALTHY BRAIN AND CHILD DEVELOPMENT NATIONAL CONSORTIUM (HBCD-NC) HAS BEEN FORMED TO DEPLOY A HARMONIZED, OPTIMIZED, AND INNOVATIVE SET OF NEUROIMAGING (MRI, EEG) MEASURES COMPLEMENTED BY AN EXTENSIVE BATTERY OF BEHAVIORAL, PHYSIOLOGICAL, AND PSYCHOLOGICAL TOOLS, AND BIOSPECIMENS TO UNDERSTAND NEURODEVELOPMENTAL TRAJECTORIES IN A SAMPLE OF 7,500 MOTHERS AND INFANTS ENROLLED AT 24 SITES ACROSS THE UNITED STATES (US). THE HBCD-NC WILL CARRY OUT A COMMON RESEARCH PROTOCOL UNDER DIRECTION OF THE HBCD- NC ADMINISTRATIVE CORE (HCAC) AND WILL ASSEMBLE AND DISTRIBUTE A COMPREHENSIVE AND WELL-CURATED RESEARCH DATASET TO THE SCIENTIFIC COMMUNITY AT LARGE UNDER THE DIRECTION OF THE HBCD-NC DATA COORDINATING CENTER (HDCC). THE OVERARCHING GOAL OF THE HBCD-NC IS TO CREATE A COMPREHENSIVE, HARMONIZED, AND HIGH- DIMENSIONAL DATASET THAT WILL CHARACTERIZE TYPICAL NEURODEVELOPMENTAL TRAJECTORIES IN US CHILDREN AND THAT WILL ASSESS HOW BIOLOGICAL AND ENVIRONMENTAL EXPOSURES AFFECT THOSE TRAJECTORIES. A SPECIAL EMPHASIS WILL BE PLACED ON UNDERSTANDING THE IMPACT OF PRE- AND POSTNATAL EXPOSURE TO OPIOIDS, MARIJUANA, ALCOHOL, TOBACCO AND/OR OTHER SUBSTANCES. TO ADDRESS THESE BROAD OBJECTIVES, THE SAMPLE OF WOMEN ENROLLED WILL INCLUDE: 1) A RACIALLY, ETHNICALLY, AND SOCIOECONOMICALLY DIVERSE COHORT THAT IS REPRESENTATIVE OF THE US POPULATION; 2) PREGNANT WOMAN WITH USE OF TARGETED SUBSTANCES (OPIOIDS, MARIJUANA, ALCOHOL, TOBACCO); AND 3) DEMOGRAPHICALLY AND BEHAVIORALLY SIMILAR WOMEN WITHOUT SUBSTANCE USE IN PREGNANCY TO ENABLE VALID CAUSAL INFERENCES. IN ADDITION, THE HBCD-NC WILL IDENTIFY KEY DEVELOPMENTAL WINDOWS DURING WHICH BOTH HARMFUL AND PROTECTIVE ENVIRONMENTS HAVE THE MOST INFLUENCE ON LATER NEURODEVELOPMENTAL OUTCOMES. THE LARGE, MULTI- MODAL, LONGITUDINAL, AND GENERALIZABLE DATASET THAT WILL BE PRODUCED FOR THE FIRST TIME BY THIS STUDY WILL PROVIDE NOVEL INSIGHTS INTO CHILD DEVELOPMENT USING STATE-OF-THE-ART METHODS. THE HBCD-NC STUDY WILL INFORM PUBLIC POLICY TO IMPROVE THE HEALTH AND DEVELOPMENT OF CHILDREN ACROSS THE NATION.

CARDIOVASCULAR DISEASE EPIDEMIOLOGY & PREVENTION TRNG

PROCESSED FOOD INTAKE, METABOLOMICS, AND ADIPOSITY

GENE THERAPY FOR METABOLIC DISORDERS