Childrens Health Inc

CHILDREN'S HOSPITALS GRADUATE MEDICAL EDUCATION PAYMENT PROGRAM

SUPPORTING HEALTHY START PERFORMANCE PROJECT

PROVIDING SUPPORT FOR THE COLLABORTIVE IMPROVEMENT AND INNOVATION NETWORK (COIIN) TO REDUCE INFANT M

HOSPITAL-BASED LEARNING COLLABORATIVES TO IMPROVE MATERNITY CARE PRACTICES RELATE

STATE MATERNAL HEALTH INNOVATION SUPPORT AND IMPLEMENTATION PROGRAM - • ADDRESS: 308 CONGRESS ST, FL 5, BOSTON, MA 02210 • PROJECT DIRECTOR: STACEY PENNY • PHONE NUMBERS: 617-391-2700 (VOICE), 617-391-2743 (FAX) • EMAIL: SPENNY@NICHQ.ORG • WEBSITE: WWW.NICHQ.ORG • LIST ALL GRANT PROGRAM FUNDS REQUESTED IN THE APPLICATION: $15,000,000 OVER 5 YEARS THE RATES OF MATERNAL MORTALITY AND SEVERE MATERNAL MORBIDITY (SMM) IN THE U.S. ARE ALARMINGLY HIGH, AND SIGNIFICANT DISPARITIES BY RACE AND ETHNICITY EXIST. TO ADDRESS THIS PROBLEM, STATES AND COMMUNITIES REQUIRE RESPONSIVE SERVICES THAT FACILITATE ACCESS TO QUALITY HEALTH CARE AND COMMUNITY SUPPORTS; ACCURATE MATERNAL HEALTH DATA AND ROBUST EVALUATION PROCESSES; AND INNOVATIVE, EQUITABLE, AND POPULATION/COMMUNITY-SPECIFIC INTERVENTIONS. IN RESPONSE TO THIS NEED, HRSA FUNDS SEVERAL MATERNAL HEALTH INITIATIVES, INCLUDING THE STATE MATERNAL HEALTH INNOVATION (STATE MHI) PROGRAM. THE MATERNAL HEALTH TRAINING AND RESOURCE CENTER (MHTRC) WILL PROVIDE CAPACITY BUILDING ASSISTANCE (CBA), TRAINING, AND TECHNICAL ASSISTANCE (TTA) TO STATE MHI AND OTHER HRSA MCHB AWARD RECIPIENTS. THE NATIONAL INSTITUTE FOR CHILDREN’S HEALTH QUALITY (NICHQ) WILL LEAD THE MHTRC IN COLLABORATION WITH KEY PARTNER THE ASSOCIATION OF MATERNAL & CHILD HEALTH PROGRAMS, AND OTHER CORE PARTNERS THE ASSOCIATION OF STATE AND TERRITORIAL HEALTH OFFICIALS, REPRODUCTIVE HEALTH IMPACT, AND HEALTHCONNECT ONE (MHTRC COLLABORATIVE). TO ENSURE COMMUNITY VOICES ARE EMBEDDED IN MHTRC EFFORTS, A COMMUNITY-CENTERED APPROACH WILL BE EMPLOYED TO SUPPORT THE INNOVATIVE INITIATIVES UNDERTAKEN BY STATE MHI RECIPIENTS TO IMPROVE MATERNAL HEALTH OUTCOMES FOR MARGINALIZED AND MEDICALLY UNDERSERVED POPULATIONS. THE MHTRC COLLABORATIVE WILL WORK CLOSELY WITH A MATERNAL HEALTH ACTION ALLIANCE (MHAA) WHOSE MEMBERSHIP WILL REPRESENT DIVERSE PARTNERS AND EXPERTS INCLUDING GOVERNMENT AGENCIES AND NATIONAL AND REGIONAL ORGANIZATIONS, COMMUNITY-BASED ORGANIZATIONS, AND NATIONAL EQUITY EXPERTS, INCLUDING BLACK, INDIGENOUS AND PE OPLE OF COLOR (BIPOC)-LED ORGANIZATIONS. THE MHAA WILL ADVISE ON TTA OFFERINGS, INCLUDING ENSURING THEY ARE CULTURALLY SENSITIVE, RELEVANT, AND TAILORED TO ADDRESS THE NEEDS OF COMMUNITIES; PROVIDE INPUT ON RESOURCES AND TOOLS FOR GRANTEES; AND MAINTAIN KNOWLEDGE SHARING AMONG THE GROUP TO DRIVE MUTUALLY BENEFICIAL PARTNERSHIPS. SPECIFICALLY, THE MHTRC WILL: • GATHER INPUT FROM GRANTEES, HRSA, AND EXPERTS TO ENSURE THAT MHTRC SUPPORT IS RELEVANT TO AND REFLECTIVE OF THE NEEDS OF THE COMMUNITIES SERVED BY THE GRANTEES, SUPPORT THE UPTAKE OF EVIDENCE-BASED STRATEGIES, AND TARGET STRUCTURAL BARRIERS AND ELEMENTS THAT DRIVE ADVERSE MATERNAL HEALTH OUTCOMES; • IDENTIFY THE BEST MECHANISMS TO FULFILL GRANTEES’ NEEDS FROM VARIOUS INNOVATIVE TTA FORMATS INCLUDING BOTH INDIVIDUALIZED TA (E.G., CONSULTATION WITH A SUBJECT MATTER EXPERT) AND GROUP OPPORTUNITIES (E.G., WEBINARS, COMMUNITIES OF PRACTICE, MENTORSHIP PROGRAM); • DEVELOP AND IMPLEMENT TTA OFFERINGS IN PARTNERSHIP WITH SUBJECT MATTER EXPERTS; • CONDUCT AN ENVIRONMENTAL SCAN AND DEVELOP AND DELIVER COMPREHENSIVE CBA BASED ON THE RESULTS; • SUPPORT AND ATTEND GRANTEE SITE VISITS; • LIFT UP AND WIDELY DISSEMINATE INFORMATION ABOUT MHTRC OFFERINGS AND GRANTEES’ SUCCESSES THROUGH VARIOUS CHANNELS FOR GRANTEES AND EXTERNAL PARTIES (INCLUDING VIA THE MHTRC NATIONAL RESOURCE CENTER WEBSITE, SOCIAL MEDIA, AND CONFERENCES); • CONDUCT POLICY ANALYSIS TO EXAMINE AND ENGAGE POLICIES AFFECTING MATERNAL MORTALITY, SMM, MATERNAL HEALTH, AND BIRTH EQUITY AND SUPPORT STATE MHI RECIPIENTS AND THE BROADER MATERNAL AND CHILD HEALTH WORKFORCE SKILLS TO ENGAGE IN THE POLICYMAKING PROCESS. A PROGRAM EVALUATION WILL FOCUS ON EVALUATING METHODS TO FACILITATE CONTINUOUS CYCLES OF IMPROVEMENT AND ASSESSING HOW TO ENHANCE SUCCESS THROUGHOUT THE PROJECT; AND A PERFORMANCE OUTCOMES EVALUATION WILL FOCUS ON THE EXTENT TO WHICH PROJECT OBJECTIVES AND PROCESS MEASURES ARE MET.

ACA PREVENTION CENTER FOR HEALTHY WEIGHT

THE MISSION OF MIDWEST REGIONAL CHILDREN’S ADVOCACY CENTER (MRCAC) IS TO IMPROVE THE COMMUNITY RESPONSE TO CHILD ABUSE THROUGH STRATEGIC LEADERSHIP, COLLABORATION, AND CAPACITY BUILDING WITH THE VISION THAT ALL CHILDREN AND FAMILIES WILL HAVE ACCESS TO A STRONG TEAM OF HIGHLY QUALIFIED PROFESSIONALS TO RESPOND TO AND HEAL FROM CHILD ABUSE. THE TARGET POPULATIONS MRCAC SERVES ARE THE MULTIDISCIPLINARY TEAMS (MDTS), CHILDREN’S ADVOCACY CENTERS, AND STATE CHAPTER ORGANIZATIONS LOCATED IN THE 12-STATE MIDWEST REGION. MRCAC HAS A STRONG RECORD OF DEVELOPING AND DISSEMINATING INNOVATIVE PROGRAMMING FOR THESE POPULATIONS – WITHIN THE REGION, AS WELL AS NATIONALLY AND INTERNATIONALLY – SINCE FIRST EARNING VICTIMS OF CHILD ABUSE ACT REGIONAL CHILDREN’S ADVOCACY CENTER PROGRAM FUNDING IN 1999.  IN THE NEXT PROJECT YEAR, MRCAC WILL DIRECT EFFORTS IN THE FOLLOWING AREAS: 1) INCREASING THE SKILLS, KNOWLEDGE, AND PEER SUPPORT NETWORK OF MDT MEMBERS AND CAC STAFF, WITH SPECIAL EMPHASIS ON EMPLOYING MRCAC’S EXPERTISE IN MEDICAL TRAINING TO IMPROVE ACCESS TO AND QUALITY OF MEDICAL PROVIDERS; 2) WORKING FOR AND ALONGSIDE STATE CHAPTER ORGANIZATIONS TO INCREASE AND ENGAGE THEIR CAPACITY TO CREATE CHANGE IN THEIR RESPECTIVE STATES; AND 3) MAXIMIZING THE POTENTIAL OF STATE, REGIONAL, AND NATIONAL PARTNERSHIPS AND COLLABORATIVE STRUCTURES TO ENHANCE THE MULTIDISCIPLINARY RESPONSE TO CHILD ABUSE IN AMERICA.  MRCAC IS COMMITTED TO PROVIDING AFFORDABLE, ACCESSIBLE, AND COST-EFFECTIVE TRAINING FOR MDTS BY UTILIZING THE LATEST TECHNOLOGY AND RESEARCH TO DELIVER TIMELY, RELEVANT, AND HIGH-IMPACT PROGRAMS. MRCAC’S STAFF IS HIGHLY EXPERIENCED IN DEVELOPING, COORDINATING, AND DISSEMINATING TRAINING AND TECHNICAL ASSISTANCE TO MDT PROFESSIONALS, AND HAS CONSISTENTLY AND EFFICIENTLY UTILIZED FEDERAL AWARDS WITHIN BUDGET AND WITHIN THE DESIRED GRANT PERIOD. MRCAC COLLECTS AND MAINTAINS DATA ON PROJECT ACTIVITIES, PARTICIPANT ENGAGEMENT, AND PROGRAM EVALUATION, ENSURING FULL AND ACCURATE COMPLIANCE WITH SCHEDULED AND AD HOC OJJDP DATA REQUIREMENTS. EVALUATIONS ARE REVIEWED ON AN ONGOING BASIS TO TROUBLESHOOT TECHNICAL ISSUES, IDENTIFY PROGRAM STRENGTHS, PINPOINT POSSIBLE AREAS OF PROGRAM IMPROVEMENT, AND CAPTURE THEMES RELATED TO FUTURE TRAINING AND TECHNICAL ASSISTANCE NEEDS. TO ENSURE THE GREATEST IMPACT AND NON-DUPLICATIVE SERVICE DELIVERY, MRCAC WILL COORDINATE AND COLLABORATE WITH THE ROBUST NETWORK OF LOCAL, REGIONAL, AND NATIONAL ENTITIES WORKING TO IMPROVE THE NATIONAL RESPONSE TO CHILD ABUSE.

MIDWEST REGIONAL CHILDREN'S ADVOCACY CENTER 2018 VOCAA TRAINING AND TECHNICAL ASSISTANCE GRANT

NICHQ NATIONAL NETWORK OF PERINATAL QUALITY COLLABORATIVES (NNPQC) - COORDINATING CENTER (COMPONENT B) - OVER THE PAST SEVERAL DECADES THE INFANT MORTALITY RATE IN THE U.S. HAS IMPROVED, HOWEVER, IN RECENT YEARS, RATES OF DECLINE HAVE SLOWED AND DISPARITIES IN RATES PERSIST BY RACE/ETHNICITY, GEOGRAPHY, AND OTHER SOCIAL DETERMINANTS OF HEALTH (E.G., EDUCATION, INCOME). FURTHER, MATERNAL MORTALITY AND MORBIDITY RATES ARE ON THE RISE, WITH EXTREME DISPARITIES IN OUTCOMES. PERINATAL QUALITY COLLABORATIVES (PQCS) ARE UNIQUELY POSITIONED TO ACCELERATE IMPROVEMENT AND REDUCE DISPARITIES IN INFANT MORTALITY, MATERNAL MORTALITY AND MATERNAL MORBIDITY OUTCOMES. THE NATIONAL INSTITUTE FOR CHILDREN’S HEALTH QUALITY (NICHQ), A NATIONALLY RECOGNIZED LEADER IN QUALITY IMPROVEMENT (QI) METHODOLOGY AND COLLABORATIVE LEARNING, PROPOSES TO SERVE AS THE COORDINATING CENTER FOR THE NATIONAL NETWORK OF PERINATAL QUALITY COLLABORATIVES (NNPQC) – COMPONENT B. AS THE COORDINATING CENTER FOR THE NNPQC FROM 2017-2022, NICHQ HAS ESTABLISHED COLLABORATIVE WORKING RELATIONSHIPS WITH ALL PQCS ACROSS THE US AND WILL LEVERAGE A DEEP KNOWLEDGE OF PQCS’ STRENGTHS AND CHALLENGES TO GUIDE THE PROVISION OF RELEVANT, TIMELY, AND EFFECTIVE SUPPORT. KEY PARTNERSHIPS WITH THE INSTITUTE FOR HEALTHCARE IMPROVEMENT AND THE MARCH OF DIMES, WILL FURTHER ENSURE PQCS HAVE ACCESS TO THE CAPACITY BUILDING RESOURCES, TECHNICAL ASSISTANCE (TA), AND PARTNERSHIPS NEEDED TO ACCELERATE AND DEEPEN IMPROVEMENT EFFORTS TO REDUCE MATERNAL AND INFANT MORBIDITY AND MORTALITY, IMPROVE PERINATAL HEALTH OUTCOMES, AND REDUCE DISPARITIES THROUGH THE USE OF QI AND IMPLEMENTATION SCIENCE METHODS INTEGRATED WITH A HEALTH EQUITY APPROACH. NICHQ WILL DEVELOP A TAILORED APPROACH TO TA AND SUPPORT, COMPOSED OF ACTIVITIES THAT WILL INCREASE COLLABORATION WITHIN AND ACROSS PQCS AND IMPROVE PQCS’ CAPACITY TO USE QI TO IMPROVE PERINATAL OUTCOMES. SPECIFICALLY, NICHQ WILL: -CONDUCT AN ANNUAL ASSESSMENT OF CAPACITY, TA NEEDS, FACILITY PARTICIPATION, AND QI EFFORTS OF PQCS -STRENGTHEN SKILLS IN QI METHODOLOGY (ALL PQCS) AND IMPLEMENTATION SCIENCE (FUNDED PQCS) USING RESULTS OF THE ANNUAL ASSESSMENT TO DEVELOP INDIVIDUALIZED AND GROUP APPROACHES ACCORDING TO THE NEEDS AND READINESS OF EACH PQC -INCREASE ENGAGEMENT OF PATIENTS, FAMILIES AND COMMUNITIES IN PQC INITIATIVES -SUPPORT THE INTEGRATION OF HEALTH EQUITY ACROSS PQC INITIATIVES THROUGH THE DEVELOPMENT OF A HEALTH EQUITY COMMUNITY OF PRACTICE -COLLABORATE WITH THE ALLIANCE FOR INNOVATION IN MATERNAL HEALTH DATA COMMUNITY OF LEARNING TO SUPPORT PQCS AROUND THE USE AND DEVELOPMENT OF DATA SYSTEMS -PROVIDE DISSEMINATION STRATEGIES TO FUNDED PQCS TO ASSIST THEM WITH SHARING INITIATIVE RESULTS, LESSONS LEARNED, AND BEST PRACTICES -FOSTER CONSISTENT COLLABORATIVE PEER-TO-PEER SHARING AND LEARNING VIA MULTIPLE PLATFORMS INCLUDING MONTHLY TA CALLS, GROUP COACHING CALLS, AND A STANDALONE NNPQC WEBSITE NICHQ’S NNPQC STRATEGIES AND ACTIVITIES WILL DRIVE TOWARD THE FOLLOWING EXPECTED OUTCOMES: SHORT TERM OUTCOMES -INCREASED IMPLEMENTATION OF QI INITIATIVES ACROSS THE NATION, INCLUDING FACILITIES SERVING DISPROPORTIONATELY IMPACTED POPULATIONS -INCREASED IMPLEMENTATION OF QI INITIATIVES TO REDUCE DISPARITIES ACROSS THE NATION -INCREASED PATIENT/COMMUNITY ENGAGEMENT WITH PQCS THROUGHOUT THE US INTERMEDIATE OUTCOMES: -IMPROVED HEALTH CARE PRACTICES EQUITABLY -IMPROVED CLINICAL-COMMUNITY LINKAGES LONG TERM OUTCOMES: -EQUITABLE IMPROVEMENT IN POPULATION-LEVEL PERINATAL MEASURES PROCESS AND OUTCOME EVALUATIONS WILL ADDRESS THE EFFICACY OF THE NNPQC IN INCREASING PQC KNOWLEDGE AND CAPACITY AROUND IMPLEMENTATION OF QI AND INCREASING REACH AND IMPLEMENTATION OF QI ACTIVITIES AMONG PQCS NATIONALLY, PARTICULARLY AMONG THOSE FACILITIES SERVING THOSE DISPROPORTIONATELY IMPACTED BY ADVERSE PERINATAL OUTCOMES. ULTIMATELY, OVER THE COURSE OF THE FIVE-YEAR PROJECT, NICHQ WILL ASSIST PQCS TO REDUCE MATERNAL AND INFANT MORTALITY, IMPROVE HEALTH OUTCOMES, AND REDUCE DISPARITIES

MIDWEST REGIONAL CHILDRENÂ??S ADVOCACY CENTER OJJDP FY 2016 VOCA PROGRAM APPLICATION

CHILDREN'S HOSPITALS GRADUATE MEDICAL EDUCATION PAYMENT PROGRAM

CHILDREN'S HOSPITALS GRADUATE MEDICAL EDUCATION PAYMENT PROGRAM

EARLY CHILDHOOD COMPREHENSIVE SYSTEMS

CHILDREN'S HOSPITALS GRADUATE MEDICAL EDUCATION PAYMENT PROGRAM

MIDWEST REGIONAL CHILDREN'S ADVOCACY CENTER

SAFE INFANT SLEEP SYSTEMS INTEGRATION (SISSI) PROGRAM

CHILDREN'S HOSPITALS GRADUATE MEDICAL EDUCATION PAYMENT PROGRAM

CHILDREN'S HOSPITALS GRADUATE MEDICAL EDUCATION PAYMENT PROGRAM

CHILDREN'S HOSPITALS GRADUATE MEDICAL EDUCATION PAYMENT PROGRAM

SICKLE CELL

CHILDREN'S HOSPITALS GRADUATE MEDICAL EDUCATION PAYMENT PROGRAM

MIDWEST REGIONAL CHILDREN'S ADVOCACY CENTER (MRCAC)

CHILDREN'S HOSPITALS GRADUATE MEDICAL EDUCATION PAYMENT PROGRAM

CHILDREN'S HOSPITALS GRADUATE MEDICAL EDUCATION PAYMENT PROGRAM

RYAN WHITE TITLE IV WOMEN, INFANTS, CHILDREN, YOUTH AND AFFECTED FAMILY MEMBERS AIDS HEALTHCARE

CHILDREN'S HOSPITALS GRADUATE MEDICAL EDUCATION PAYMENT PROGRAM

SAFE INFANT SLEEP SYSTEMS INTEGRATION (SISSI) PROGRAM

EARLY CHILDHOOD COMPREHENSIVE SYSTEMS

CHILDREN'S HOSPITALS GRADUATE MEDICAL EDUCATION PAYMENT PROGRAM

DETECTING DICER1: A GLOBAL PARTNERSHIP TO CURE PEDIATRIC LUNG CANCER

CHILDREN'S HOSPITALS GRADUATE MEDICAL EDUCATION PAYMENT PROGRAM

CHILDREN'S HOSPITALS GRADUATE MEDICAL EDUCATION PAYMENT PROGRAM

DEVELOPMENT & DISSEMINATION OF EDUCATION IN PEDIATRIC PALLIATIVE CARE

COORDINATING CENTER FOR NATIONAL NETWORK OF STATE PERINATAL QUALITY COLLABORATIVES (MODULE B)

CHILDREN'S HOSPITALS GRADUATE MEDICAL EDUCATION PAYMENT PROGRAM

CHILDREN'S HOSPITALS GRADUATE MEDICAL EDUCATION PAYMENT PROGRAM

CHILDREN'S HOSPITALS GRADUATE MEDICAL EDUCATION PAYMENT PROGRAM

MIDWEST REGIONAL CHILDREN'S ADVOCACY CENTER (MRCAC)

MIDWEST REGIONAL CHILDREN''S ADVOCACY CENTER (MRCAC)

MIDWEST REGIONAL CHILDREN'S ADVOCACY CENTER (MRCAC)

MIDWEST REGIONAL CHILDREN''S ADVOCACY CENTER

SEE NOTICE OF AWARD, ATTACHMENT 1 - TERMS AND CONDITIONS, ATTACHMENT D - STATEMENT OF WORK, ABSTRACT

COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - CONSTRUCTION

HEALTH CARE AND OTHER FACILITIES

(EARMARK: ACF/CB) IMPROVING ACCESS TO COMPREHENSIVE CHILD ABUSE SERVICES

HEALTH CARE AND OTHER FACILITIES

PROVIDING SUPPORT FOR THE COLLABORTIVE IMPROVEMENT AND INNOVATION NETWORK (COIIN) TO REDUCE INFANT M

OSTEOPONTIN AS A BLOOD BIOMARKER IN SEVERE PEDIATRIC TRAUMATIC BRAIN INJURY

A NOVEL VPREB1 ANTI-BODY DRUG CONJUGATE FOR THE TREATMENT OF B-LINEAGE ACUTE LYMPHOBLASTIC LEUKEMIA/LYMPHOMA - A NOVEL VPREB1 ANTIBODY-DRUG CONJUGATE FOR THE TREATMENT OF B-LINEAGE ACUTE LYMPHOBLASTIC LEUKEMIA/LYMPHOMA B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (B-ALL) IS THE MOST COMMON MALIGNANCY IN CHILDREN AND YOUNG ADULTS. B- ALL RELAPSE IS A COMMON PROBLEM AMONG INFANTS, ADOLESCENTS, AND ADULTS AT ALL STAGES. B-ALLS THAT RELAPSE AFTER CELL-BASED THERAPIES DEMONSTRATE ANTIGEN REMODELING, DOWN-REGULATION OF TARGETED ANTIGENS, AND LINEAGE SWITCHES TO DIFFERENT TYPES OF LEUKEMIA. HOWEVER, THE MOLECULAR AND CELLULAR MECHANISMS THAT LEAD TO THE EMERGENCE OF RESISTANT LEUKEMIC CELLS ARE NOT WELL UNDERSTOOD. NEARLY ALL B-ALL CASES SHARE A RESTRICTED REPERTOIRE OF B-CELL SURFACE MARKERS. CELL-BASED THERAPIES TARGETING THESE SURFACE RECEPTORS UNFORTUNATELY ELIMINATE ALL NORMAL B CELLS, CAUSING PAN B-CELL ABLATION AND IMMUNE DYSREGULATION. THIS LEADS TO SERIOUS COMPLICATIONS AND THE RISK OF DEATH DUE TO INFECTION IN A SIGNIFICANT FRACTION OF PEOPLE WHO HAVE SUFFERED MULTIPLE RELAPSES. TO IMPROVE PATIENT SAFETY, OUR PROJECT ADDRESSES THE PROBLEMS OF RELAPSE, OPPORTUNISTIC INFECTIONS, AND ORGAN TOXICITIES IN B-ALL. THE PRE-B-CELL RECEPTOR (PRE-BCR) AUTONOMOUSLY SIGNALS TO CARRY DEVELOPING B-CELLS THROUGH THE PRO- AND PRE-B STAGES OF DIFFERENTIATION. B-ALL IS USUALLY ARRESTED AT THE PRO- AND PRE-B STAGES OF DIFFERENTIATION, WHERE THESE CELLS ARE SUBJECT TO PRE-BCR-MEDIATED AUTONOMOUS SIGNALING, SURVIVAL, AND CLONAL EXPANSION. WE HYPOTHESIZE THAT OUR NOVEL VPREB1 ADC AGAINST THE PRE-BCR WILL DE-COUPLE THE PATHWAYS THAT ALLOWS LEUKEMIA CELLS TO SURVIVE AND BECOME RESISTANT TO CONVENTIONAL CHEMOTHERAPY. THERAPIES LIKE THE ONE WE ARE DEVELOPING HAVE LOTS OF TOXICITIES, INCLUDING SIDE EFFECTS THAT HARM LIVER CELLS AND THE CELLS OF THE IMMUNE SYSTEM THAT MAKES ANTIBODIES AGAINST INFECTIOUS DISEASES. BETTER IMMUNOTHERAPIES CAN LEAD TO LESS ORGAN DAMAGE, REDUCE OPPORTUNISTIC INFECTIONS, AND DIRECTLY TARGET THE RESISTANCE MECHANISMS THAT LEAD TO RESIDUAL DISEASE IN B-ALL. NO CURRENT B-ALL IMMUNOTHERAPIES TARGET AUTONOMOUS SURVIVAL SIGNALING. THIS PROJECT IS BEING EXPRESSLY DEVELOPED TO BENEFIT CHILDREN, WHO HAVE UNIQUE PHYSIOLOGIES AND TOXICITY PROFILES. BY USING AN ACBUT-CALICHEAMICIN LINKER AND PAYLOAD, WE WILL GAIN INSIGHT INTO SAFETY DATA THAT HAVE BEEN COLLECTED BY THE CHILDREN’S ONCOLOGY GROUP FOR CHILDREN RECEIVING SIMILAR LINKER-TOXIN PAYLOADS. OUR APPROACH IS RESPONSIVE TO THE FDA’S BEST PHARMACEUTICALS ACT OF 2017, WHICH CALLS FOR NEW DRUGS FOR CHILDREN AND YOUNG ADULTS WHO FACE LIFE-THREATENING DISEASES, INCLUDING B-ALL IN RELAPSE OR WITH HIGH- RISK DISEASE AT DIAGNOSIS. IN SUMMARY AND IN RESPONSE TO PAR-20-292, OUR PROPOSAL DESCRIBES THE DEVELOPMENT OF A NOVEL BIOLOGIC AGENT, WITH STRATEGIES TO MITIGATE TREATMENT-RELATED TOXICITIES FOR CHILDREN AND YOUNG ADULTS WHO REQUIRE TREATMENT FOR B-ALL. IN THIS PROPOSAL, WE WILL: CONTINUE THE DEVELOPMENTAL TRAJECTORY OF A NOVEL ADC TO ADDRESS THE PROBLEMS OF RELAPSE, OPPORTUNISTIC INFECTIONS, AND OTHER TOXICITIES IN THE TREATMENT OF B-ALL; EVALUATE HOW WELL OUR NOVEL ADC TARGETS RESIDUAL DISEASE IN TREATMENT-RESISTANT B-ALL; ASSESS THE SURVIVAL AND ADVERSE DRUG EFFECTS OF OUR ADC, ESPECIALLY ITS EFFECT ON ORGAN TOXICITIES AND INFECTIOUS COMPLICATIONS; EVALUATE HOW WELL OUR NOVEL ADC SPARES ADAPTIVE IMMUNITY IN B-ALL.

HEALTH CARE AND OTHER FACILITIES

HEALTH CARE AND OTHER FACILITIES

HEALTH CARE AND OTHER FACILITIES

HEALTH CARE AND OTHER FACILITIES

OTHER HEALTH PROFESSIONS PROGRAMS (EARMARKS)

HEALTH CARE AND OTHER FACILITIES

INTEGRATING EVIDENCE-BASED MENTAL HEALTH SCREENING INTO CHKD CHILD ABUSE PROGRAM SERVICES.

CONGRESSIONALLY-MANDATED HEALTH INFORMATION TECHNOLOGY GRANTS