Fraser Ltd

VANCOUVER DRUG USERS STUDY: EVALUATING THE NATURAL HISTORY OF INJECTION DRUG USE

LOCALIZED ECONOMIC MODELING TO OPTIMIZE PUBLIC HEALTH STRATEGIES FOR HIV TREATMENT AND PREVENTION

FRASER CCBHC PLANNING, DEVELOPMENT, AND IMPLEMENTATION - FRASER IS ONE OF THE LARGEST NONPROFIT COMMUNITY MENTAL HEALTH PROGRAMS IN MINNESOTA. WE SERVE MORE THAN 8,000 CHILDREN AND ADULTS EACH YEAR AT SIX CLINICS AND MULTIPLE COMMUNITY PARTNER LOCATIONS. THIS GRANT WILL FUND THE "FRASER CCBHC PLANNING, DEVELOPMENT, AND IMPLEMENTATION" PROJECT. BY THE END OF THE FIRST GRANT YEAR, OUR LARGEST CLINIC IN THE CITY OF BLOOMINGTON AND THE CATCHMENT AREA OF HENNEPIN COUNTY WILL BE A FULLY CERTIFIED CCBHC. OVER THE COURSE OF THE FOUR GRANT YEARS, WE WILL STRIVE TOWARD OUR GOALS OF CLOSING DISPARITIES IN ACCESS TO COMPREHENSIVE INTEGRATED SERVICES, WHOLE-PERSON HEALTH OUTCOMES, AND OTHER STRUCTURAL INEQUITIES FACING OUR COMMUNITY. OVER THAT TIME, WE WILL ALSO SERVE AN ADDITIONAL 750 INDIVIDUALS. THE PRIMARY FOCUS OF THE FIRST GRANT YEAR WILL BE COMPLETING OUR STATE'S FORMAL CERTIFICATION PROCESS, WHICH WE WILL FINISH NO LATER THAN SEPTEMBER 2023. KEY GRANT-FUNDED ACTIVITIES TOWARD THIS MILESTONE WILL INCLUDE EXPANDING OUR INTERDISCIPLINARY TEAM WITH ADDITIONAL STAFF SUCH AS A SUBSTANCE USE SPECIALIST AND A PEER SPECIALIST, COMPLETING A COMPREHENSIVE NEEDS ASSESSMENT WITH CONSUMER INPUT GATHERED BY A COMMUNITY FACILITATOR, AND ADDING CARE COORDINATORS TO HELP OUR CLIENTS NAVIGATE WITHIN OUR CLINIC AND ACROSS THE COMMUNITY. THIS GRANT ALSO WILL HELP US IMPLEMENT CRITICAL CCBHC INFRASTRUCTURE IN THE FORM OF A NEW ELECTRONIC HEALTH RECORD TO COORDINATE AND INTEGRATE CARE. BY THE END OF THE FIRST GRANT YEAR, WE WILL DEVELOP A SUSTAINABILITY PLAN. OUR PLAN WILL RELY HEAVILY ON LEVERAGING THE PROSPECTIVE PAYMENT RATE WE WILL RECEIVE ONCE WE COMPLETE STATE CERTIFICATION. BECAUSE ABOUT A THIRD OF OUR CLIENTS ARE NOT COVERED BY MEDICAID, OUR PLAN ALSO WILL DIRECT AS MUCH OF THE GRANT FUNDS AS POSSIBLE IN YEARS TWO, THREE, AND FOUR TOWARD PROVIDING ACCESS TO CCBHC SERVICES FOR UNINSURED AND UNDER-INSURED CLIENTS. OUR PROJECT WILL BE LED BY OUR LONG-TIME DIRECTOR OF CLINICAL QUALITY AND STAFF DEVELOPMENT. SHE IS A CLINICAL PSYCHOLOGIST WITH DEEP EXPERIENCE HELPING OUR PROGRAMS IMPLEMENT NEW REGULATIONS WHILE CUSTOMIZING THEM FOR THE UNIQUE SPECIALTY POPULATIONS WE SERVE. FINALLY, IF WE ARE AWARDED THIS GRANT, WE WILL PARTNER CLOSELY WITH OUR STATE TO ENSURE THAT WE MEET OUR STATE'S RIGOROUS CERTIFICATION STANDARDS AND MAINTAIN OUR STATUS AS A CCBHC.

SYNTHETIC BACTERIAL ANALOGS OF MAMMALIAN OLIGOMANNOSE FOR ELICITING NEUTRALIZING ANTIBODIES TO THE HIGH-MANNOSE PATCH ON HIV ENV

TOBACCO COMPANIES, PUBLIC POLICY AND GLOBAL HEALTH

VACCINES THAT REPLICATE THE NEUTRALIZATION-COMPETENT STRUCTURE OF THE GP41 MPER

DAT-EMULATING TARGET TRIALS WITH BIG DATA TO STRENGTHEN THE EVIDENCE BASE FOR THE CLINICAL MANAGEMENT OF OPIOID USE DISORDER - ABSTRACT DAT18-06 IN 2016, FOLLOWING A DRAMATIC INCREASE IN OPIOID-RELATED OVERDOSE DEATHS, THE PROVINCE OF BRITISH COLUMBIA (BC), CANADA DECLARED A PUBLIC HEALTH EMERGENCY. BC REPORTED 1,510 ILLICIT DRUG OVERDOSE DEATHS IN 2018, A RATE OF 31.0 PER 100,000, PLACING IT 10TH AMONG US STATES, EQUAL TO RHODE ISLAND (31.0), BEHIND WEST VIRGINIA (57.8), OHIO (46.3) AND PENNSYLVANIA (44.3) BUT AHEAD OF NEW JERSEY (30.0), MICHIGAN (27.8) AND FLORIDA (25.1). WHILE THE FOUR-FOLD INCREASE IN OVERDOSE DEATHS OBSERVED SINCE 2012 IS LARGELY ATTRIBUTABLE TO THE CONTAMINATION OF FENTANYL AND OTHER SYNTHETIC OPIOIDS IN THE ILLICIT DRUG SUPPLY, MANY DECEDENTS HAD SOUGHT TREATMENT IN THE PAST AND EXPERIENCED RELAPSES. OPIOID AGONIST TREATMENT (OAT) IS AMONG THE MOST EFFECTIVE TOOLS AVAILABLE TO COMBAT THE EPIDEMIC. HOWEVER, OAT UPTAKE AND RETENTION IS SUB-OPTIMAL IN BC AND INTERNATIONALLY, COMPROMISED LARGELY BY SOCIAL AND STRUCTURAL FACTORS BUT ALSO DEVIATIONS FROM EVIDENCE-BASED STANDARDS OF CARE AND FRAGMENTED CARE, PARTICULARLY FOR THOSE WITH CONCURRENT DISORDERS. FURTHERMORE, A NUMBER OF ASPECTS OF CANADIAN AND US CLINICAL GUIDELINES FOR THE MANAGEMENT OF OPIOID USE DISORDER (OUD) ARE BASED ON LIMITED AND LOW-QUALITY EVIDENCE. EVEN BASIC EVIDENCE ON THE COMPARATIVE EFFECTIVENESS OF AVAILABLE TREATMENT OPTIONS OVERALL AND FOR KEY POPULATIONS IN THE FENTANYL ERA IS LACKING. THIS PROPOSAL AIMS TO APPLY CUTTING-EDGE METHODS FOR CAUSAL INFERENCE IN EMULATING A SERIES OF ‘TARGET TRIALS’ IN THREE IMMEDIATE AIMS: (1) TO DETERMINE THE COMPARATIVE EFFECTIVENESS OF METHADONE VERSUS BUPRENORPHINE/NALOXONE FOR DIFFERENT PATIENT SUBGROUPS PRESENTING FOR OAT; (2) TO DETERMINE THE IMPACT OF URINE DRUG SCREENING – A UBIQUITOUS AND NON-EVIDENCE- BASED ELEMENT OF OUD CARE – ON OAT RETENTION AND MORTALITY; AND (3) TO DETERMINE THE COMPLEMENTARY EFFECTS OF OAT ON UPTAKE AND ADHERENCE TO DIRECTING-ACTING ANTIVIRALS FOR PEOPLE WITH OPIOID USE DISORDER (PWOUD) WITH CONCURRENT HEPATITIS C VIRUS. THE ‘TARGET TRIAL’ FRAMEWORK CHANNELS COUNTERFACTUAL THEORY IN PROVIDING A FLEXIBLE BASIS FOR COMPARING THE EFFECTS OF TREATMENT AND CLINICAL MANAGEMENT STRATEGIES ON EITHER AN INTENT-TO-TREAT OR PER-PROTOCOL BASIS. WE HAVE IDENTIFIED A NUMBER OF ADDITIONAL QUESTIONS RELATED TO THE CLINICAL MANAGEMENT OF PWOUD WHERE GUIDELINES ARE SUPPORTED BY WEAKER EMPIRICAL EVIDENCE AND WILL ENDEAVOR TO ANSWER AS MANY OF THESE QUESTIONS AS POSSIBLE, PRIORITIZING ANALYSIS USING A COMMON FRAMEWORK FOCUSED ON METHODOLOGICAL RIGOR AND

HAART OPTIMISM, DRUG USE AND RISKY SEXUAL BEHAVIOR AMONG MSM IN BRITISH COLUMBIA.

AN ETHNO-EPIDEMIOLOGICAL STUDY TO ADVANCE HIV PREVENTION AND TREATMENT FOR PWUD

MULTIFAMILY HOUSING SERVICE COORDINATORS

ASSISTANCE TO FIREFIGHTERS GRANTS

TO FOSTER EFFICIENCY COMPETITIVE OPERATIONS AND QUALITY SHIP CONSTRUCTION REPAIR AND RECONFIGURATION IN SMALL SHIPYARDS ACROSS THE UNITED STATES IN ADDITION TO FOSTERING EMPLOYEE SKILLS AND ENHANCED PRODUCTIVITY RELATED TO SHIPBUILDING SHIP REPAIR AND ASSOCIATED INDUSTRIES THIS GRANT IS FOR THE PURCHASE AND INSTALLATION OF A LINK BELT 130-TON TELESCOPIC BOOM ROUGH TERRAIN CRANE DELIVERABLES ARE A LINK BELT 130-TON TELESCOPIC BOOM ROUGH TERRAIN CRANE WHICH WILL INCREASE EFFICIENCY IN WITHIN THE SHIPYARD INTENDED BENEFICIARY IS FRASER SHIPYARDS LLC THERE ARE NO SUBRECIPIENT ACTIVITIES

OVERHEAD MATERIAL HANDLING AND STEEL BRAKE PROCESSING IMPROVEMENT

DEVELOPMENT OF FERROELECTRIC MATERIALS WITH ENHANCED PIEZOELECTRIC AND OPTICAL PROPERTIES VIA DOMAIN ENGINEERING FOR ELECTROMECHANICAL TRANSDUCER APPL

HIGH-PERFORMANCE PIEZO- AND FERROELECTRIC MATERIALS FOR ELECTROMECHANICAL TRANSDUCER APPLICATIONS

PURCHASE OF 2 SELF-PROPELLED MODULAR TRANSPORTERS (SPMT) AND HIGH CAPACITY FORKLIFT

INFORMATION TECHNOLOGY RESEARCH (ITR): ITR/ANIR 100 MB/SEC FOR 100 MILLION HOUSEHOLDS

DEVELOPMENT OF HIGH-PERFORMANCE PIEZO- AND FERROELECTRIC MATERIALS FOR ELECTROMECHANICAL TRANSDUCER APPLICATIONS

CONTROL OF ENERGY MINIMIZATION IN HUMAN LOCOMOTION.

FERTILITY DESIRE AND PREGNANCY IN A COHORT OF DISCORDANT UGANDAN COUPLES ON ART

GENETICS, DYNAMICS AND FITNESS OF THE HIV-1 LATENT RESERVOIR

DEVELOPMENT OF HIGH-PERFORMANCE PIEZO- AND FERRO-ELECTRIC MATERIALS FOR ELECTROMECHANICAL TRANSDUCTION APPLICATIONS

EXPLORING ANTIBODY RECOGNITION OF THE V3 REGION ON HIV-1 TO GUIDE VACCINE DESIGN

THE NON-FATAL OVERDOSE CRISIS: SEX AND GENDER DIFFERENCES IN HEALTHCARE UTILIZATION AND HEALTH OUTCOMES OF PEOPLE LIVING WITH AND WITHOUT HIV BETWEEN 2012 AND 2020 - PROJECT SUMMARY/ABSTRACT THE OVERDOSE (OD) CRISIS CONTINUES TO DEVASTATE COMMUNITIES ACROSS NORTH AMERICA. DESPITE 90% OF PARAMEDIC- ATTENDED ODS IN BRITISH COLUMBIA (BC), CANADA BEING NON-FATAL, MUCH OF THE RESEARCH HAS FOCUSED ON FATAL ODS. WHILE MEN ACCOUNT FOR OVER 70% OF FATAL ODS, THERE IS EVIDENCE OF A MORE BALANCED DISTRIBUTION OF MEN AND WOMEN EXPERIENCING NON-FATAL ODS (NFODS); FURTHER, WOMEN HAVE HIGHER MORTALITY RATES IN THE YEAR FOLLOWING AN NFOD. PEOPLE LIVING WITH HIV (PLHIV) ARE DISPROPORTIONATELY AFFECTED BY THE OD CRISIS AND ARE AT INCREASED RISK OF FATAL ODS, YET LITTLE IS KNOWN ABOUT THE LONGER-TERM IMPACTS OF NFODS ON PLHIV IN TERMS OF ADVERSE HEALTH OUTCOMES AND HEALTHCARE UTILIZATION (HCU). CONSIDERING THE INCREASINGLY HIGH RATES OF NFODS, GENDERED DIFFERENCES IN MORTALITY FOLLOWING AN NFOD, AND KNOWLEDGE GAPS CONCERNING HEALTH OUTCOMES FOLLOWING AN NFOD, THIS PROPOSAL SEEKS FUNDING TO INVESTIGATE THE ROLE OF SEX, GENDER, AND HIV STATUS IN DIFFERENTIAL NFOD OUTCOMES. BC’S UNIVERSAL HEALTHCARE SYSTEM AND DATA CENTRALIZATION ENABLED THE COMPARATIVE OUTCOMES AND SERVICE UTILIZATION TRENDS (COAST) STUDY, A POPULATION-BASED LONGITUDINAL COHORT COMPRISED OF LINKED ADMINISTRATIVE HEALTH DATASETS ON ALL KNOWN ADULT PLHIV AND A 10% RANDOM SAMPLE OF THE GENERAL POPULATION IN BC. USING COAST, WE AIM TO: (1) GENERATE ESTIMATES FOR THE INCIDENCE RATES OF FATAL AND NONFATAL ODS AMONG PEOPLE LIVING WITH AND WITHOUT HIV (2012-2020) IN BC; (2) ASSESS AND COMPARE CHANGES IN HEALTH CARE UTILIZATION, CHRONIC COMORBIDITY, AND MORTALITY AMONG PEOPLE LIVING WITH AND WITHOUT HIV WHO EXPERIENCED AN NFOD, MODIFIED BY SEX AND GENDER; AND (3) ASSESS AND COMPARE CHANGES IN HIV TREATMENT OUTCOMES IN PEOPLE LIVING WITH HIV WHO EXPERIENCED AN NFOD, MODIFIED BY SEX AND GENDER. THIS PROJECT WILL ALSO INVOLVE THE DEVELOPMENT OF A COMMUNITY ADVISORY BOARD (CAB) FOR PROPOSED AND FUTURE PROJECTS. THE CAB WILL PROVIDE GUIDANCE TO ENSURE RESEARCH SOUNDNESS AND RELEVANCE TO THE COMMUNITY THROUGHOUT THE RESEARCH AND KNOWLEDGE MOBILIZATION PROCESSES. OUR COLLABORATIVE RESEARCH WILL BE AN OPPORTUNITY TO EXPLORE OTHER RESEARCH POSSIBILITIES INITIATED BY THE CAB AS IMPORTANT FOR WOMEN AND GENDER MINORITIES LIVING WITH AND WITHOUT HIV WHO ARE AFFECTED BY THE OD CRISIS. IN RESPONSE TO THE NATIONAL INSTITUTE ON DRUG ABUSE NOTICE OF SPECIAL INTEREST NOT-DA- 21-021 TO ADVANCE RESEARCH SPECIFIC TO WOMEN AND OTHER UNDERREPRESENTED POPULATIONS INCLUDING GENDER MINORITIES, THIS PROPOSAL WILL INFORM FUTURE CAB-LED CYCLES OF INQUIRY AND ANALYSIS AMONGST OUR TEAM TO ANSWER RELEVANT RESEARCH QUESTIONS AND ADDRESS THE IDENTIFIED NEEDS OF CISGENDER WOMEN AND GENDER MINORITIES LIVING WITH AND WITHOUT HIV AFFECTED BY THE OD CRISIS.

RELEVANCE OF SERUM MANNOSIDASE RESISTANCE TO THE SPECIFICITY OF OLIGOMANNOSE-TARGETING ANTIBODIES - PROJECT SUMMARY THE GLYCANS THAT DECORATE THE HIV ENVELOPE GLYCOPROTEIN SPIKE (ENV) ARE CATEGORIZED NOMINALLY AS ‘SELF’ ANTIGENS GIVEN THAT THEY ARE IMPARTED BY THE MAMMALIAN CELL’S GLYCOSYLATION MACHINERY. HOWEVER, GLYCANS OF THE OLIGOMANNOSE-TYPE FOUND ON GP120 ARE MOSTLY CLUSTERED INTO A PATCH, CREATING A ‘NON-SELF’ ARCHITECTURE. THIS OLIGOMANNOSE PATCH IS VULNERABLE TO RECOGNITION BY ANTI-HIV BROADLY NEUTRALIZING ANTIBODIES (BNABS). GIVEN THE POTENCY AND BREADTH OF BNABS TO THE OLIGOMANNOSE PATCH, THERE IS GREAT INTEREST IN DEVELOPING IMMUNIZATION STRATEGIES TO ELICIT SIMILAR BNABS. THIS PROJECT AIMS TO FILL A GAP IN UNDERSTANDING BARRIERS TO THE ELICITATION OF OLIGOMANNOSE-SPECIFIC BNABS. WE AND OTHERS HAVE RECENTLY REPORTED ON A SOLUBLE MANNOSIDASE FOUND IN MAMMALIAN SERUM THAT TRIMS OLIGOMANNOSIDES ON GLYCOCONJUGATES DESIGNED TO ELICIT OLIGOMANNOSE-SPECIFIC ANTIBODIES UPON IMMUNIZATION. SUCH TRIMMING WOULD EXPLAIN WHY IMMUNIZING WITH OLIGOMANNOSIDIC GLYCOCONJUGATES TYPICALLY YIELDS ANTIBODIES THAT BIND WELL TO SUBSTRUCTURES OF OLIGOMANNOSE BUT THAT BIND WITH SUBSTANTIALLY LOWER AVIDITY TO FULL-SIZED OLIGOMANNOSE AS PRESENTED ON ENV; THE LATTER TYPIFIES THE BINDING MANNER OF BNABS THAT TARGET THE OLIGOMANNOSE PATCH. IN THIS APPLICATION, WE PROPOSE TO DETERMINE THE EXTENT TO WHICH SERUM MANNOSIDASE ACTIVITY IS RELEVANT TO THE QUALITY OF OLIGOMANNOSE-SPECIFIC ANTIBODY RESPONSES. SPECIFICALLY, WE INTEND TO CONSTRUCT A MANNOSIDASE-RESISTANT GLYCOSIDE, THUS REPRESENTING THE GREATEST POSSIBLE RESISTANCE TO MANNOSIDASE TRIMMING, AND DETERMINE THE SPECIFICITY OF THE ENSUING ANTIBODY RESPONSE COMPARED TO ITS MANNOSIDASE- SENSITIVE OPPOSITE. THE PROJECT WILL TAKE ADVANTAGE OF OUR PUBLISHED WORK OF A BACTERIALLY INSPIRED MIMIC OF OLIGOMANNOSE THAT, AS A NEOGLYCOCONJUGATE, ELICITS MODEST LEVELS OF HIV-NEUTRALIZING ANTIBODIES. WE WILL INVESTIGATE ANTIBODY RESPONSES AT THE POLYCLONAL SERUM LEVEL AS WELL AS THE MONOCLONAL LEVEL; THE LATTER SHOULD REVEAL SIMILARITIES, IF ANY, BETWEEN THE ELICITED ANTIBODIES AND EXISTING BNABS. IN SUM, WE EXPECT THE RESULTS OF THIS PROJECT TO SHED LIGHT ON BARRIERS TO EVOKING ANTIBODIES WITH CAPACITY TO BIND THE HIGHLY VULNERABLE OLIGOMANNOSE PATCH ON HIV ENV. ALTHOUGH THE DIFFICULTY IN ELICITING OLIGOMANNOSE-SPECIFIC BNABS IS OFTEN ASSUMED TO STEM FROM B CELL TOLERANCE, OUR PRELIMINARY STUDIES PROVIDE EVIDENCE FOR SERUM MANNOSIDASE POSING AT LEAST AN ADDITIONAL HINDRANCE.

YOUTH HOMELESSNESS DEMONSTRATION PROGRAM

DEVELOPMENT OF NOVEL HYBRID ORGANIC-INORGANIC HALIDE PEROVSKITE MATERIALS FOR PIEZOELECTRIC AND MULTIFUNCTIONAL DEVICES

ORIGIN OF ANTIBODIES WITH LONG CDR-H3 LOOPS IN HIV INFECTION & AUTOIMMUNE DISEASE

IDENTIFICATION CHARACTERIZATION AND VALIDATION OF GENETIC MUTATIONS INCURRED DURING IN VITRO ATTENUATION OF MAREK'S DISEASE VIRUS

DEVELOPMENT OF HIGH-PERFORMANCE PIEZO- AND FERROELECTRIC SINGLE CRYSTALS FOR ELECTROMECHANICAL TRANSDUCER APPLICATIONS

PURPOSE: THE CONTINUUM OF CARE (COC) PROGRAM IS DESIGNED TO PROMOTE COMMUNITY-WIDE COMMITMENT TO THE GOAL OF ENDING HOMELESSNESS; PROVIDE FUNDING FOR EFFORTS BY NONPROFIT PROVIDERS, STATES, AND LOCAL GOVERNMENTS TO QUICKLY HOUSE HOMELESS INDIVIDUALS AND FAMILIES WHILE MINIMIZING THE TRAUMA AND DISLOCATION CAUSED TO HOMELESS INDIVIDUALS, FAMILIES, AND COMMUNITIES BY HOMELESSNESS; PROMOTE ACCESS TO AND EFFECTIVE UTILIZATION OF MAINSTREAM PROGRAMS BY HOMELESS INDIVIDUALS AND FAMILIES; AND OPTIMIZE SELF-SUFFICIENCY AMONG INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS. THE MOST RECENT COC AWARD ANNOUNCEMENT LISTING AWARDS BY STATE AND COC IS ACCESSIBLE AT HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/COC/AWARDS. SELECT THE LINK UNDER THE FUNDING AND AWARD INFORMATION SECTION FOR THE APPROPRIATE FISCAL YEAR.; ACTIVITIES TO BE PERFORMED: CONTINUUM OF CARE PROGRAM FUNDS MAY BE USED TO PAY FOR THE ELIGIBLE COSTS USED TO ESTABLISH AND OPERATE PROJECTS UNDER FIVE PROGRAM COMPONENTS: (1) PERMANENT HOUSING, WHICH INCLUDES PERMANENT SUPPORTIVE HOUSING FOR PERSONS WITH DISABILITIES, AND RAPID REHOUSING; (2) TRANSITIONAL HOUSING; (3) SUPPORTIVE SERVICES ONLY; (4) HOMELESS MANAGEMENT INFORMATION SYSTEMS (HMIS), AND (5) IN SOME CASES, HOMELESSNESS PREVENTION. THIRTEEN TYPES OF ASSISTANCE MAY BE PROVIDED THROUGH THE CONTINUUM OF CARE (COC) PROGRAM: (1) COC PLANNING ACTIVITIES/COSTS FOR DESIGNING AND CARRYING OUT A COLLABORATIVE PROCESS FOR THE DEVELOPMENT OF AN APPLICATION TO HUD; (2) UNITED FUNDING AGENCY (UFA) COSTS FOR FISCAL CONTROL AND ACCOUNTING NECESSARY TO ASSURE THE PROPER DISBURSAL OF, AND ACCOUNTING FOR, FEDERAL FUNDS AWARDED TO SUBRECIPIENTS UNDER THE CONTINUUM OF CARE PROGRAM, (3) ACQUISITION OF REAL PROPERTY (INCLUDING STRUCTURES) FOR USE IN THE PROVISION OF HOUSING OR SUPPORTIVE SERVICES; (4) REHABILITATION OF STRUCTURES TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (5) NEW CONSTRUCTION, INCLUDING THE BUILDING OF A NEW STRUCTURE OR BUILDING AN ADDITION TO AN EXISTING STRUCTURE FOR USE AS SUPPORTIVE HOUSING; (6) LEASING OF A STRUCTURE OR STRUCTURES, OR PORTIONS THEREOF, TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (7) RENTAL ASSISTANCE, WHICH MAY BE SHORT-TERM, MEDIUM-TERM, OR LONG-TERM, AS WELL AS TENANT-BASED, PROJECT-BASED, OR SPONSOR-BASED, FOR TRANSITIONAL OR PERMANENT HOUSING; (8) SUPPORTIVE SERVICES TO ASSIST PROGRAM PARTICIPANTS OBTAIN AND MAINTAIN HOUSING; (9) OPERATING COSTS OF SUPPORTIVE HOUSING; (10) COSTS OF IMPLEMENTING AND OPERATING HMIS; (11) PROJECT ADMINISTRATIVE COSTS; (12) RELOCATION COSTS; AND (13) INDIRECT COSTS IN ACCORDANCE WITH 2 CFR PARTS 200, AS APPLICABLE. IN ADDITION TO USING GRANT FUNDS FOR THE ELIGIBLE COSTS DESCRIBED ABOVE, RECIPIENTS AND SUBRECIPIENTS IN CONTINUUMS OF CARE DESIGNATED AS HIGH PERFORMING COMMUNITIES MAY ALSO USE GRANT FUNDS TO PROVIDE HOUSING RELOCATION AND STABILIZATION SERVICES AND SHORT- AND/OR MEDIUM-TERM RENTAL ASSISTANCE TO INDIVIDUALS AND FAMILIES AT RISK OF HOMELESSNESS AS SET FORTH IN 24 CFR 576.103 AND 24 CFR 576.104, IF NECESSARY TO PREVENT THE INDIVIDUAL OR FAMILY FROM BECOMING HOMELESS. LIMITATION ON USE OF FUNDS: NO ASSISTANCE PROVIDED UNDER PROGRAM (OR ANY STATE OR LOCAL GOVERNMENT FUNDS USED TO SUPPLEMENT THIS ASSISTANCE) MAY BE USED TO REPLACE STATE OR LOCAL FUNDS PREVIOUSLY USED, OR DESIGNATED FOR USE, TO ASSIST HOMELESS PERSONS OR PERSONS AT-RISK OF HOMELESSNESS.; EXPECTED OUTCOMES: DECREASE IN THE NUMBER INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS, MORE SPECIFICALLY USING PERFORMANCE INDICATORS SUCH AS THE LENGTH OF TIME HOMELESS, RETURNS TO HOMELESSNESS OVER TIME, AND EXITS TO PERMANENT HOUSING. COC PERFORMANCE PROFILE REPORTS CAN BE FOUND AT HTTPS://WWW.HUDEXCHANGE.INFO/PROGRAMS/COC/COC-PERFORMANCE-PROFILE-REPORTS/.; INTENDED BENEFICIARIES: INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

CONTINUUM OF CARE PROGRAM

PURPOSE: THE CONTINUUM OF CARE (COC) PROGRAM IS DESIGNED TO PROMOTE COMMUNITY-WIDE COMMITMENT TO THE GOAL OF ENDING HOMELESSNESS; PROVIDE FUNDING FOR EFFORTS BY NONPROFIT PROVIDERS, STATES, AND LOCAL GOVERNMENTS TO QUICKLY HOUSE HOMELESS INDIVIDUALS AND FAMILIES WHILE MINIMIZING THE TRAUMA AND DISLOCATION CAUSED TO HOMELESS INDIVIDUALS, FAMILIES, AND COMMUNITIES BY HOMELESSNESS; PROMOTE ACCESS TO AND EFFECTIVE UTILIZATION OF MAINSTREAM PROGRAMS BY HOMELESS INDIVIDUALS AND FAMILIES; AND OPTIMIZE SELF-SUFFICIENCY AMONG INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS. THE MOST RECENT COC AWARD ANNOUNCEMENT LISTING AWARDS BY STATE AND COC IS ACCESSIBLE AT HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/COC/AWARDS. SELECT THE LINK UNDER THE FUNDING AND AWARD INFORMATION SECTION FOR THE APPROPRIATE FISCAL YEAR.; ACTIVITIES TO BE PERFORMED: CONTINUUM OF CARE PROGRAM FUNDS MAY BE USED TO PAY FOR THE ELIGIBLE COSTS USED TO ESTABLISH AND OPERATE PROJECTS UNDER FIVE PROGRAM COMPONENTS: (1) PERMANENT HOUSING, WHICH INCLUDES PERMANENT SUPPORTIVE HOUSING FOR PERSONS WITH DISABILITIES, AND RAPID REHOUSING; (2) TRANSITIONAL HOUSING; (3) SUPPORTIVE SERVICES ONLY; (4) HOMELESS MANAGEMENT INFORMATION SYSTEMS (HMIS), AND (5) IN SOME CASES, HOMELESSNESS PREVENTION. THIRTEEN TYPES OF ASSISTANCE MAY BE PROVIDED THROUGH THE CONTINUUM OF CARE (COC) PROGRAM: (1) COC PLANNING ACTIVITIES/COSTS FOR DESIGNING AND CARRYING OUT A COLLABORATIVE PROCESS FOR THE DEVELOPMENT OF AN APPLICATION TO HUD; (2) UNITED FUNDING AGENCY (UFA) COSTS FOR FISCAL CONTROL AND ACCOUNTING NECESSARY TO ASSURE THE PROPER DISBURSAL OF, AND ACCOUNTING FOR, FEDERAL FUNDS AWARDED TO SUBRECIPIENTS UNDER THE CONTINUUM OF CARE PROGRAM, (3) ACQUISITION OF REAL PROPERTY (INCLUDING STRUCTURES) FOR USE IN THE PROVISION OF HOUSING OR SUPPORTIVE SERVICES; (4) REHABILITATION OF STRUCTURES TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (5) NEW CONSTRUCTION, INCLUDING THE BUILDING OF A NEW STRUCTURE OR BUILDING AN ADDITION TO AN EXISTING STRUCTURE FOR USE AS SUPPORTIVE HOUSING; (6) LEASING OF A STRUCTURE OR STRUCTURES, OR PORTIONS THEREOF, TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (7) RENTAL ASSISTANCE, WHICH MAY BE SHORT-TERM, MEDIUM-TERM, OR LONG-TERM, AS WELL AS TENANT-BASED, PROJECT-BASED, OR SPONSOR-BASED, FOR TRANSITIONAL OR PERMANENT HOUSING; (8) SUPPORTIVE SERVICES TO ASSIST PROGRAM PARTICIPANTS OBTAIN AND MAINTAIN HOUSING; (9) OPERATING COSTS OF SUPPORTIVE HOUSING; (10) COSTS OF IMPLEMENTING AND OPERATING HMIS; (11) PROJECT ADMINISTRATIVE COSTS; (12) RELOCATION COSTS; AND (13) INDIRECT COSTS IN ACCORDANCE WITH 2 CFR PARTS 200, AS APPLICABLE. IN ADDITION TO USING GRANT FUNDS FOR THE ELIGIBLE COSTS DESCRIBED ABOVE, RECIPIENTS AND SUBRECIPIENTS IN CONTINUUMS OF CARE DESIGNATED AS HIGH PERFORMING COMMUNITIES MAY ALSO USE GRANT FUNDS TO PROVIDE HOUSING RELOCATION AND STABILIZATION SERVICES AND SHORT- AND/OR MEDIUM-TERM RENTAL ASSISTANCE TO INDIVIDUALS AND FAMILIES AT RISK OF HOMELESSNESS AS SET FORTH IN 24 CFR 576.103 AND 24 CFR 576.104, IF NECESSARY TO PREVENT THE INDIVIDUAL OR FAMILY FROM BECOMING HOMELESS. LIMITATION ON USE OF FUNDS: NO ASSISTANCE PROVIDED UNDER PROGRAM (OR ANY STATE OR LOCAL GOVERNMENT FUNDS USED TO SUPPLEMENT THIS ASSISTANCE) MAY BE USED TO REPLACE STATE OR LOCAL FUNDS PREVIOUSLY USED, OR DESIGNATED FOR USE, TO ASSIST HOMELESS PERSONS OR PERSONS AT-RISK OF HOMELESSNESS.; EXPECTED OUTCOMES: DECREASE IN THE NUMBER INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS, MORE SPECIFICALLY USING PERFORMANCE INDICATORS SUCH AS THE LENGTH OF TIME HOMELESS, RETURNS TO HOMELESSNESS OVER TIME, AND EXITS TO PERMANENT HOUSING. COC PERFORMANCE PROFILE REPORTS CAN BE FOUND AT HTTPS://WWW.HUDEXCHANGE.INFO/PROGRAMS/COC/COC-PERFORMANCE-PROFILE-REPORTS/.; INTENDED BENEFICIARIES: INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

THE EFFECT OF NORMOXIC DIVES ON NARCOSIS AND HEART FUNCTION IN HUMAN AND CELLULAR MODELS

PURPOSE: THE CONTINUUM OF CARE (COC) PROGRAM IS DESIGNED TO PROMOTE COMMUNITY-WIDE COMMITMENT TO THE GOAL OF ENDING HOMELESSNESS; PROVIDE FUNDING FOR EFFORTS BY NONPROFIT PROVIDERS, STATES, AND LOCAL GOVERNMENTS TO QUICKLY HOUSE HOMELESS INDIVIDUALS AND FAMILIES WHILE MINIMIZING THE TRAUMA AND DISLOCATION CAUSED TO HOMELESS INDIVIDUALS, FAMILIES, AND COMMUNITIES BY HOMELESSNESS; PROMOTE ACCESS TO AND EFFECTIVE UTILIZATION OF MAINSTREAM PROGRAMS BY HOMELESS INDIVIDUALS AND FAMILIES; AND OPTIMIZE SELF-SUFFICIENCY AMONG INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS. THE MOST RECENT COC AWARD ANNOUNCEMENT LISTING AWARDS BY STATE AND COC IS ACCESSIBLE AT HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/COC/AWARDS. SELECT THE LINK UNDER THE FUNDING AND AWARD INFORMATION SECTION FOR THE APPROPRIATE FISCAL YEAR.; ACTIVITIES TO BE PERFORMED: CONTINUUM OF CARE PROGRAM FUNDS MAY BE USED TO PAY FOR THE ELIGIBLE COSTS USED TO ESTABLISH AND OPERATE PROJECTS UNDER FIVE PROGRAM COMPONENTS: (1) PERMANENT HOUSING, WHICH INCLUDES PERMANENT SUPPORTIVE HOUSING FOR PERSONS WITH DISABILITIES, AND RAPID REHOUSING; (2) TRANSITIONAL HOUSING; (3) SUPPORTIVE SERVICES ONLY; (4) HOMELESS MANAGEMENT INFORMATION SYSTEMS (HMIS), AND (5) IN SOME CASES, HOMELESSNESS PREVENTION. THIRTEEN TYPES OF ASSISTANCE MAY BE PROVIDED THROUGH THE CONTINUUM OF CARE (COC) PROGRAM: (1) COC PLANNING ACTIVITIES/COSTS FOR DESIGNING AND CARRYING OUT A COLLABORATIVE PROCESS FOR THE DEVELOPMENT OF AN APPLICATION TO HUD; (2) UNITED FUNDING AGENCY (UFA) COSTS FOR FISCAL CONTROL AND ACCOUNTING NECESSARY TO ASSURE THE PROPER DISBURSAL OF, AND ACCOUNTING FOR, FEDERAL FUNDS AWARDED TO SUBRECIPIENTS UNDER THE CONTINUUM OF CARE PROGRAM, (3) ACQUISITION OF REAL PROPERTY (INCLUDING STRUCTURES) FOR USE IN THE PROVISION OF HOUSING OR SUPPORTIVE SERVICES; (4) REHABILITATION OF STRUCTURES TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (5) NEW CONSTRUCTION, INCLUDING THE BUILDING OF A NEW STRUCTURE OR BUILDING AN ADDITION TO AN EXISTING STRUCTURE FOR USE AS SUPPORTIVE HOUSING; (6) LEASING OF A STRUCTURE OR STRUCTURES, OR PORTIONS THEREOF, TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (7) RENTAL ASSISTANCE, WHICH MAY BE SHORT-TERM, MEDIUM-TERM, OR LONG-TERM, AS WELL AS TENANT-BASED, PROJECT-BASED, OR SPONSOR-BASED, FOR TRANSITIONAL OR PERMANENT HOUSING; (8) SUPPORTIVE SERVICES TO ASSIST PROGRAM PARTICIPANTS OBTAIN AND MAINTAIN HOUSING; (9) OPERATING COSTS OF SUPPORTIVE HOUSING; (10) COSTS OF IMPLEMENTING AND OPERATING HMIS; (11) PROJECT ADMINISTRATIVE COSTS; (12) RELOCATION COSTS; AND (13) INDIRECT COSTS IN ACCORDANCE WITH 2 CFR PARTS 200, AS APPLICABLE. IN ADDITION TO USING GRANT FUNDS FOR THE ELIGIBLE COSTS DESCRIBED ABOVE, RECIPIENTS AND SUBRECIPIENTS IN CONTINUUMS OF CARE DESIGNATED AS HIGH PERFORMING COMMUNITIES MAY ALSO USE GRANT FUNDS TO PROVIDE HOUSING RELOCATION AND STABILIZATION SERVICES AND SHORT- AND/OR MEDIUM-TERM RENTAL ASSISTANCE TO INDIVIDUALS AND FAMILIES AT RISK OF HOMELESSNESS AS SET FORTH IN 24 CFR 576.103 AND 24 CFR 576.104, IF NECESSARY TO PREVENT THE INDIVIDUAL OR FAMILY FROM BECOMING HOMELESS. LIMITATION ON USE OF FUNDS: NO ASSISTANCE PROVIDED UNDER PROGRAM (OR ANY STATE OR LOCAL GOVERNMENT FUNDS USED TO SUPPLEMENT THIS ASSISTANCE) MAY BE USED TO REPLACE STATE OR LOCAL FUNDS PREVIOUSLY USED, OR DESIGNATED FOR USE, TO ASSIST HOMELESS PERSONS OR PERSONS AT-RISK OF HOMELESSNESS.; EXPECTED OUTCOMES: DECREASE IN THE NUMBER INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS, MORE SPECIFICALLY USING PERFORMANCE INDICATORS SUCH AS THE LENGTH OF TIME HOMELESS, RETURNS TO HOMELESSNESS OVER TIME, AND EXITS TO PERMANENT HOUSING. COC PERFORMANCE PROFILE REPORTS CAN BE FOUND AT HTTPS://WWW.HUDEXCHANGE.INFO/PROGRAMS/COC/COC-PERFORMANCE-PROFILE-REPORTS/.; INTENDED BENEFICIARIES: INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

PRECLINICAL TESTING OF AN O-GLCNACASE INHIBITOR TO BLOCK NEURODEGENERATION FOR AD

CONTINUUM OF CARE PROGRAM

CONTINUUM OF CARE PROGRAM

CONTINUUM OF CARE PROGRAM

CONTINUUM OF CARE PROGRAM

CONTINUUM OF CARE PROGRAM

CONTINUUM OF CARE PROGRAM

CONTINUUM OF CARE PROGRAM

CONTINUUM OF CARE PROGRAM

CONTINUUM OF CARE PROGRAM

SUPPORTIVE HOUSING NEW

ASSISTANCE TO FIREFIGHTERS GRANTS

GENETIC ANALYSIS OF IDIOPATHIC-TYPE CURVATURE IN MODEL TELEOSTS

SAWFISH CONSERVATION PLANNING IN EAST AFRICA

THE TOWN OF FRASER, LOCATED IN THE ROCKY MOUNTAINS OF COLORADO, WILL INSTALL ADVANCED METERING INFRASTRUCTURE WITH 380 NEW METERS AND CELLULAR ENDPOINTS. THE PROJECT WILL IMPROVE THE TOWNS EFFICIENT MANAGEMENT OF WATER SUPPLY BY ACQUIRING REAL-TIME CONSUMPTION DATA, WITH ALGORITHMIC ANALYSIS TOOLS TO IDENTIFY WATER LOSSES AND EXCESSIVE WATER USE. THE DATA WILL BE USED TO ENCOURAGE WATER CONSERVATION DETECT LEAKS WITHIN CUSTOMERS HOMES, PREVENT RUPTURES DUE TO FROZEN PIPES BY ALERTING STAFF TO FREEZING TEMPERATURES IN THE PLUMBING, AND RECORD WATER CONSUMPTION THROUGHOUT THE SYSTEM. THIS PROJECT IS SUPPORTED BY THE TOWN OF FRASER 2023 WATER EFFICIENCY PLAN.

AN UNTARGETED NMR METABOLOMICS PLATFORM FOR FUNCTIONAL ANNOTATION OF NATURAL PRODUCT EXTRACTS.

ASSISTANCE TO FIREFIGHTERS GRANT

ASSISTANCE TO FIREFIGHTERS GRANT

SECURING A FUTURE FOR SAWFISHES: AN EXPERT WORKSHOP AND AWARENESS-RAISING ACTIVITIES

DEVELOPMENT OF PIEZOELECTRIC SINGLE CRYSTALS (PIEZOCRYSTALS) STANDARD

ASSISTANCE TO FIREFIGHTERS GRANT

BEHAVIORAL ECOLOGY OF HOST SELECTION BY THE ASIAN LONGHORNED BEETLE: DEVELOPMENT OF A DETECTION METHODS

LAND-USE AND SEDIMENTATION PATTERNS IN SAINT LUCIA IN RELATION TO THEIR IMPACTS ON CORAL REEFS

WORKSHOP ON RELAXOR-BASED PIEZOELECTRIC SINGLE CRYSTALS

BEHAVIORAL ECOLOGY OF HOST SELECTION BY THE ASIAN LONGHORNED BEETLE: DEVELOPMENT OF A DETECTION METHODS

CSP - THE 6TH INTERNATIONAL WORKSHOP ON RELAXOR FERROELECTRICS (IWRF-2018)

CSP - THE 13TH INTERNATIONAL SYMPOSIUM ON FERROIC DOMAINS & MICRO- TO NANO-SCOPIC STRUCTURES (ISFD-13)

MULTIFAMILY HOUSING SERVICE COORDINATORS

EFFECTS OF CLIMATE CHANGE ON MONTANE AMPHIBIANS

THE 20TH IMS NEW RESEARCHERS CONFERENCE

TO COVER TRAVEL COSTS FOR SEVERAL U.S. SPEAKERS TO PARTICIPATE IN CLEAN ENERGY CONFERENCE.

THE AWARD WILL BE USED TO COVER VENUE ROOM RENTAL AND PARTICIPATION OF UP TO EIGHT U.S. AUTHORS (HONORARIUM AND TRAVEL TO PARTICIPATE IN THE READING

IDENTIFICATION, CHARACTERIZATION, AND VALIDATION OF GENETIC MUTATIONS INCURRED DURING IN VITRO ATTENUATION OF MAREK#18;S DISEASE VIRUS

ASSISTANCE TO FIREFIGHTERS GRANT

RELIABILITY OF MEASUREMENT TOOLS AND CHALLENGES TO ADHERENCE CLINICAL TRIALS AMON