St John

CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND: INSTITUTIONAL PORTION

CARES ACT HIGHER EDUCATION EMERGENCY RELIEF FUND

HEAD START - ST. JOHN THE BAPTIST PARISH, LOUISIANA

USAID 4BETTERHEALTH PROJECT IMPROVES THE QUALITY OF LIFE OF ORPHANS AND VULNERABLE CHILDREN (OVC) AND THEIR FAMILIES BY PROVIDING GREATER ACCESS TO AND UPTAKE OF QUALITY HEALTH AND SOCIAL SERVICES.

HIGHER EDUCATION EMERGENCY RELIEF FUNDS (INSTITUTIONAL) FOR ST. JOHN FISHER COLLEGE

HEAD START CENTER BASED

IMPROVE EXISTING AIRPORT

IMPROVE EXISTING AIRPORT

HEAD START

HIGHER EDUCATION EMERGENCY RELIEF FUND: ST. JOHN FISHER COLLEGE

HEAD START

HEAD START

IMPROVE EXISTING AIRPORT C

HEAD START

IMPROVE EXISTING AIRPORT

THE HIDTA PROGRAM REDUCES ILLICIT DRUG SUPPLY BY AIDING FEDERAL, STATE, LOCAL AND TRIBAL LAW ENFORCEMENT. PERFORMANCE IS MEASURED BY DISMANTLING/DISRUPTING DRUG TRAFFICKING AND MONEY LAUNDERING ORGANIZATIONS AND IMPROVING EFFECTIVENESS OF THE INITIATIVES.

THE HIDTA PROGRAM REDUCES ILLICIT DRUG SUPPLY BY AIDING FEDERAL, STATE, LOCAL AND TRIBAL LAW ENFORCEMENT. PERFORMANCE IS MEASURED BY DISMANTLING/DISRUPTING DRUG TRAFFICKING AND MONEY LAUNDERING ORGANIZATIONS AND IMPROVING EFFECTIVENESS OF THE INITIATIVES.

THE HIDTA PROGRAM REDUCES ILLICIT DRUG SUPPLY BY AIDING FEDERAL, STATE, LOCAL AND TRIBAL LAW ENFORCEMENT. PERFORMANCE IS MEASURED BY DISMANTLING/DISRUPTING DRUG TRAFFICKING AND MONEY LAUNDERING ORGANIZATIONS AND IMPROVING EFFECTIVENESS OF THE INITIATIVES.

HIGH INTENSITY DRUG TRAFFICKING AREAS HIDTA PROGRAM FISCAL YEAR FY 2025 GRANT AWARD

SUPPORT OF INITIATIVES DESIGNED TO IMPLEMENT THE STRATEGY PROPOSED BY THE GRANTEES' GOVERNING HIDTA EXECUTIVE BOARD AND APPROVED BY ONDCP.

HIGH INTENSITY DRUG TRAFFICKING AREAS HIDTA PROGRAM FISCAL YEAR FY 2026 GRANT

THE HIDTA PROGRAM REDUCES ILLICIT DRUG SUPPLY BY AIDING FEDERAL, STATE, LOCAL AND TRIBAL LAW ENFORCEMENT. PERFORMANCE IS MEASURED BY DISMANTLING/DISRUPTING DRUG TRAFFICKING AND MONEY LAUNDERING ORGANIZATIONS AND IMPROVING EFFECTIVENESS OF THE INITIATIVES.

SUPPORT OF INITIATIVES DESIGNED TO IMPLEMENT THE STRATEGY PROPOSED BY THE GRANTEES' GOVERNING HIDTA EXECUTIVE BOARD AND APPROVED BY ONDCP.

SUPPORT OF INITIATIVES DESIGNED TO IMPLEMENT THE STRATEGY PROPOSED BY THE GRANTEES' GOVERNING HIDTA EXECUTIVE BOARD AND APPROVED BY ONDCP.

SUPPORT OF INITIATIVES DESIGNED TO IMPLEMENT THE STRATEGY PROPOSED BY THE GRANTEES' GOVERNING HIDTA EXECUTIVE BOARD AND APPROVED BY ONDCP.

WEST LAC DES ALLEMANDS SHORELINE PROTECTION

HIDTA

HIDTA

IMPACT AID PROGRAM, TITLE VII, SECTION 7003

IMPROVE EXISTING AIRPORT

IMPROVE EXISTING AIRPORT

IMPROVE EXISTING AIRPORT

HIDTA

IMPACT AID PROGRAM, TITLE VII, SECTION 7003

FY 2022 DISASTER GRANT-WATER DISPOSAL ONLY

CHILD HELP PARTNERSHIP TREATMENT AND SERVICES ADAPTATION CENTER - THE CENTER WILL TRAIN AND SUPPORT THE DELIVERY OF EVIDENCE-BASED, CULTURALLY ADAPTED TRAUMA SERVICES AND INTERVENTIONS FOR CHILDREN EXPOSED TO DISASTER, SEXUAL ABUSE, FAMILY VIOLENCE, RACE-BASED AND IMMIGRATION TRAUMA (E.G., UNACCOMPANIED MINORS), COVID-19, AND TRAUMATIC DEATHS. MAJOR STAKEHOLDERS IN CHILDREN’S MENTAL HEALTH–SCHOOL PERSONNEL, PARENTS, AND MENTAL HEALTH PROVIDERS–WILL WORK IN PARTNERSHIP TO CREATE A CONTINUUM-OF-CARE AT 18 SITES NATIONWIDE. THE CENTER AIMS TO SERVE UNDERSERVED CHILDREN (AGES 4-17) FROM CULTURALLY DIVERSE BACKGROUNDS (E.G., PEOPLE OF COLOR, LGBTQ+) WHO HAVE BEEN EXPOSED TO TRAUMA AND ARE EXPERIENCING DIVERSE MENTAL HEALTH RESPONSES. EACH SITE’S TRAUMA TEAM WILL HAVE REPRESENTATIVES FROM SCHOOLS, PARENTS, YOUTH, MENTAL HEALTH CLINICS, AND OTHER SOCIAL SYSTEMS (E.G., POLICE) AND BE RESPONSIBLE FOR IMPLEMENTING A TIERED APPROACH TO SERVICES AND INTERVENTIONS. TIER 1 IS SYSTEM-LEVEL PSYCHOEDUCATION (I.E., TRAUMA 101) TO CREATE A TRAUMA-INFORMED CULTURE AND PROVIDE A FOUNDATION FOR TRAUMA EBIS. TIER 2 IS EARLY INTERVENTION DELIVERED AFTER TRAUMA (I.E., SKILLS FOR PSYCHOLOGICAL RECOVERY) TO PREVENT THE DEVELOPMENT OF MENTAL DISORDERS. TIER 3 IS TREATMENT FOR TRAUMATIZED CHILDREN AND THEIR CAREGIVERS (I.E., TRAUMA-FOCUSED COGNITIVE-BEHAVIORAL THERAPY AND ALTERNATIVES FOR FAMILIES-A COGNITIVE-BEHAVIORAL THERAPY). AFTER BEING TRAINED AND IMPLEMENTING THE INTERVENTIONS, SCHOOL COUNSELORS AND MENTAL HEALTH SUPERVISORS WILL PARTICIPATE IN TRAIN-THE-TRAINER PROGRAMS TO TRAIN OTHERS (E.G., TEACHERS, CLINICIANS). CENTER GOALS ARE TO: (1) INCREASE COLLABORATION IN LOCAL, STATE, AND NATIONAL SCHOOL-FAMILY-MENTAL HEALTH PARTNERSHIPS, (2) INCREASE THE SIZE OF THE TRAUMA TRAINED WORKFORCE THAT CAN IDENTIFY TRAUMATIZED CHILDREN, ASSESS LEVEL OF NEED, AND PROVIDE INTERVENTIONS THAT PREVENT AND TREAT TRAUMA-RELATED MENTAL DISORDERS, (3) INCREASE THE NUMBER OF CHILDREN WHO RECEIVE TRAUMA-SPECIFIC SERVICES AND EBIS, AND (4) DECREASE CHILDREN’S TRAUMA SYMPTOMS. COMPLETION OF TRAINING IN THE MODEL TAKES 2.5 YEARS. IN THE FIRST 2.5 YEARS OF THE PROJECT, THE CENTER WILL TRAIN 8 LAUNCH SITES THAT HAVE SCHOOL-MENTAL HEALTH PARTNERSHIPS IN CULTURALLY AND GEOGRAPHICALLY DIVERSE AREAS WITH LARGE BEHAVIORAL HEALTH DISPARITIES. SIMULTANEOUSLY, THE CENTER WILL BUILD AND BETA-TEST A NEW ONLINE TRAINING PLATFORM AND INNOVATIVE PROFESSIONAL NETWORKING APPLICATION FOR WIDESPREAD DISSEMINATION AND SUSTAINABILITY. IN THE LAST 2.5 YEARS OF THE PROJECT, THE CENTER WILL TRAIN 10 NEW ROLLOUT SITES USING THE WEB-BASED PLATFORM AND PROVIDE TECHNICAL ASSISTANCE TO THE LAUNCH SITES AS THEY USE THE PLATFORM TO TRAIN THEIR COMMUNITY PARTNERS. LAUNCH SITES WILL EDUCATE 34,600 STUDENTS, PARENTS, AND STAFF IN YEAR 1, AND ADD 20% (3,382) EACH OF 4 YEARS FOR A TOTAL OF 62,359 OVER THE 5 YEARS OF THE PROJECT. ROLLOUT SITES WILL HAVE 25% MORE STUDENTS, PARENTS, AND STAFF THAN LAUNCH SITES, AND ADD 20% EACH YEAR FOR AN ESTIMATED TOTAL OF 56,000. BETWEEN LAUNCH AND ROLLOUT SITES, MORE THAN 118,000 YOUTH, PARENTS, AND STAFF WILL RECEIVE TIER 1 SERVICES AND MORE THAN 23,500 YOUTH AND THEIR PARENTS WILL RECEIVE TIER 2 EARLY INTERVENTION AND TIER 3 TREATMENT.

IMPACT AID PROGRAM, TITLE VII, SECTION 7003

PROJECT: WINGS

PROJECT LEADER

RECOVERY ACT: NE FLORIDA COASTAL WETLAND RESTORATION INITIATIVE

IMPACT AID PROGRAM, TITLE VII, SECTION 7003

IMPROVE EXISTING AIRPORT

IMPLEMENTATION AND OVERSIGHT OF THE COMPREHENSIVE CONSERVATION AND MANAGEMENT PLAN (CCMP)

IMPROVE EXISTING AIRPORT

GEAR-UP

IMPACT AID PROGRAM, TITLE VII, SECTION 7003

STAFFING FOR ADEQUATE FIRE AND EMERGENCY RESPONSE (SAFER)

BEHAVIORAL HEALTH WORKFORCE EDUCATION AND TRAINING (BHWET) PROGRAM

THIS ACTION APPROVES AN AWARD IN THE AMOUNT OF $598,800 TO THE ST. JOHNS RIVER WATER MANAGEMENT DISTRICT FOR THE IMPLEMENTATION AND OVERSIGHT OF THE

IMPACT AID PROGRAM, TITLE VII, SECTION 7003

GAINING EARLY AWARENESS AND READINESS FOR UNDERGRADUATE PROGRAMS (GEAR UP PARTNERSHIP)

UNKNOWN TITLE

FOSTERING PERSONAL EXCELLENCE: STRENGTHENING SELF-BELIEF, BELONGINGNESS, AND CAREER READINESS FOR LOW-INCOME STUDENTS IN THE SCIENCES AND MATHEMATICS -THIS PROJECT WILL CONTRIBUTE TO THE NATIONAL NEED FOR WELL-EDUCATED SCIENTISTS, MATHEMATICIANS, ENGINEERS, AND TECHNICIANS BY SUPPORTING THE RETENTION AND GRADUATION OF HIGH-ACHIEVING, LOW-INCOME STUDENTS WITH DEMONSTRATED FINANCIAL NEED AT ST. JOHN FISHER UNIVERSITY, A SMALL LIBERAL ARTS UNIVERSITY LOCATED JUST OUTSIDE ROCHESTER, NY. OVER ITS FIVE-YEAR DURATION, THIS TRACK 2 PROJECT WILL FUND SCHOLARSHIPS TO 20 UNIQUE FULL-TIME STUDENTS WHO ARE PURSUING BACHELOR'S DEGREES IN BIOLOGY, CHEMISTRY, BIOCHEMISTRY, PSYCHOLOGY, MATHEMATICS, PHYSICS, COMPUTER SCIENCE, DATA ANALYTICS, OR CYBERSECURITY. FIRST-YEAR STUDENTS WILL RECEIVE UP TO FOUR YEARS OF SCHOLARSHIP SUPPORT. THE PROJECT AIMS TO INCREASE STUDENT PERSISTENCE IN STEM FIELDS BY LINKING SCHOLARSHIPS WITH EFFECTIVE SUPPORTING ACTIVITIES, INCLUDING MENTORING, PAID UNDERGRADUATE RESEARCH EXPERIENCES, TUTORING, MINDFULNESS TRAINING, GRADUATE SCHOOL PREPARATION, AND PARTICIPATION IN DISCIPLINE-SPECIFIC CONFERENCES. BY INCREASING THE RETENTION AND GRADUATION RATES OF LOW-INCOME STEM STUDENTS, THE PROPOSED PROJECT WILL HAVE A SIGNIFICANT IMPACT NOT ONLY ON PARTICIPATING SCHOLARS BUT ALSO ON THE COMMUNITIES TO WHICH THOSE SCHOLARS WILL RETURN AFTER GRADUATION. MANY OF THE SCHOLARS REMAIN IN THE ROCHESTER REGION. THIS PROJECT HAS THE POTENTIAL TO BROADEN PARTICIPATION IN STEM FIELDS AND ADVANCE OUR UNDERSTANDING OF HOW STUDENTS' CONFIDENCE, EXPECTATIONS, AND GOALS INFLUENCE THEIR CAREER CHOICES AND SUCCESS. THE OVERALL GOAL OF THIS PROJECT IS TO INCREASE STEM DEGREE COMPLETION OF HIGH-ACHIEVING, LOW-INCOME UNDERGRADUATES WITH DEMONSTRATED FINANCIAL NEED. THE PROJECT WILL INVESTIGATE THE EFFECTS OF PSYCHOSOCIAL FACTORS ON STUDENT PERSISTENCE IN STEM, FOCUSING ON SELF-EFFICACY, OUTCOME EXPECTATIONS, AND PERSONAL GOALS. THE PROJECT WILL EMPLOY SOCIAL COGNITIVE CAREER THEORY TO BUILD ON SUCCESSFUL PRACTICES FROM A PREVIOUS AWARD PROJECT, CREATE COHORT COHESION ACROSS VARIOUS MAJORS, AND INTEGRATE CAREER READINESS PROGRAMMING INTO THE SCHOLAR EXPERIENCE. EXPECTED OUTCOMES INCLUDE INCREASED RETENTION AND GRADUATION RATES, ENHANCED CAREER READINESS, AND A STRONGER SENSE OF BELONGING IN STEM AMONG SCHOLARS. THE PROJECT WILL BE EVALUATED USING A MIXED-METHODS APPROACH, INCLUDING SURVEYS, FOCUS GROUPS, AND INSTITUTIONAL DATA ANALYSIS. RESULTS WILL BE DISSEMINATED THROUGH PRESENTATIONS AT CONFERENCES, PUBLICATIONS IN ACADEMIC JOURNALS, AND REPORTS TO STAKEHOLDERS. THIS PROJECT IS FUNDED BY NSF'S SCHOLARSHIPS IN SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS PROGRAM, WHICH SEEKS TO INCREASE THE NUMBER OF ACADEMICALLY, LOW-INCOME TALENTED STUDENTS WITH DEMONSTRATED FINANCIAL NEED WHO EARN DEGREES IN STEM FIELDS. IT ALSO AIMS TO IMPROVE THE EDUCATION OF FUTURE STEM WORKERS AND TO GENERATE KNOWLEDGE ABOUT ACADEMIC SUCCESS, RETENTION, TRANSFER, GRADUATION, AND ACADEMIC/CAREER PATHWAYS OF LOW-INCOME STUDENTS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING, AND MISCELLANEOUS GRANTS

PROJECT BRIDGE: DEVELOPING ACADEMIC PROFICIENCY OF YOUNG GIFTED ENGLISH LEARNERS WITH ADVANCED MATHEMATICS PROGRAM AND LANGUAGE SCAFFOLDING

ENGLISH LANGUAGE ACQUISITION: NATIONAL PROFESSIONAL DEVELOPMENT PROGRAM

COMMUNITY BASED JOB TRAINING

PURPOSE: REHABILITATE TAXIWAY LIGHTING; INSTALL RUNWAY LIGHTING; REHABILITATE TAXIWAY. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT INSTALLS MODIFICATIONS TO THE EXISTING RUNWAY 13/31 LIGHTING SYSTEM TO MEET FEDERAL AVIATION ADMINISTRATION DESIGN STANDARDS. . THIS PROJECT REHABILITATES 2,600 FEET OF THE EXISTING TAXIWAY B PAVEMENT TO EXTEND ITS USEFUL LIFE. THIS PROJECT REHABILITATES THE EXISTING TAXIWAY B LIGHTING SYSTEM TO EXTEND ITS USEFUL LIFE AND ENHANCE SAFE AIRFIELD OPERATIONS DURING LOW VISIBILITY CONDITIONS. THIS GRANT FUNDS THE FINAL PHASE, WHICH CONSISTS OF CONSTRUCTION. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH SAINT AUGUSTINE, FLORIDA.

ENGLISH LANGUAGE ACQUISITION: NATIONAL PROFESSIONAL DEVELOPMENT PROGRAM

IMPROVE EXISTING AIRPORT

IMPACT AID PROGRAM, TITLE VII, SECTION 7003

IMPACT AID PROGRAM, TITLE VIII, SECTION 8003

IMPACT AID PROGRAM, TITLE VIII, SECTION 8003

IMPACT AID PROGRAM, TITLE VII, SECTION 7003

IMPACT AID PROGRAM, TITLE VIII, SECTION 8003

CONSTRUCT TRANSIT FACILITY

ST. JOHNS UNIVERSITY UPWARD BOUND

PURPOSE: RECONSTRUCT PERIMETER FENCING REQUIRED BY 49 CFR 1542. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT RECONSTRUCTS 13,000 FEET OF THE EXISTING PERIMETER FENCING REQUIRED BY 49 CFR 1542 THAT HAS REACHED THE END OF ITS USEFUL LIFE. . THIS PROJECT INSTALLS SECURITY ENHANCEMENTS REQUIRED BY TITLE 49 CODE OF FEDERAL REGULATIONS, PART 1542. THE SECURITY PROJECT WAS COORDINATED WITH BRIAN CAHILL, FEDERAL SECURITY DIRECTOR, TRANSPORTATION SECURITY ADMINISTRATION, ON AUGUST 15, 2018. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH SAINT AUGUSTINE, FLORIDA.

IMPACT AID PROGRAM TITLE VIII SECTION 8003

ECONOMIC DEVELOPMENT INITIATIVE, COMMUNITY PROJECT FUNDING, AND MISCELLANEOUS GRANTS

HIGHER EDUCATION - INSTITUTIONAL AID - STRENGTHENING INSTITUTIONS

PURPOSE: EXTEND/EXPAND TAXILANE. ACTIVITIES TO BE PERFORMED/EXPECTED OUTCOMES: THIS PROJECT EXTENDS THE EXISTING SOUTH TAXILANE AN ADDITIONAL 400 FEET IN LENGTH TO PROVIDE AIRFIELD ACCESS TO A NON-EXCLUSIVE HANGAR DEVELOPMENT AREAS. INTENDED BENEFICIARY: THIS GRANT WILL PROVIDE FEDERAL FUNDING FOR AIRPORTS ASSOCIATED WITH SAINT AUGUSTINE, FLORIDA.

IMPACT AID PROGRAM, TITLE VIII, SECTION 8003

INSPIRE AND PREPARE NOYCE SCHOLARS TO TEACH IN RURAL ENVIRONMENTS

ASSISTANCE TO FIREFIGHTERS GRANT

IMPACT AID PROGRAM TITLE VIII SECTION 8003

ADVANCED NURSING EDUCATION WORKFORCE

2000-TON FLOATING DRYDOCK (200X86X8)

BEHAVIORAL HEALTH WORKFORCE EDUCATION AND TRAINING (BHWET) PROGRAM

NE FLORIDA ESTUARINE HABITAT RESTORATION INITIATIVE

COMMUNITY PROJECT FUNDING/CONGRESSIONALLY DIRECTED SPENDING - CONSTRUCTION - FOR NEARLY A CENTURY, THE ST. JOHN’S UNIVERSITY COLLEGE OF PHARMACY AND HEALTH SCIENCES HAS BEEN THE LARGEST EDUCATOR OF HEALTH CARE PERSONNEL IN THE NEW YORK METROPOLITAN AREA. ESTABLISHING A BACHELOR OF SCIENCE IN NURSING PROGRAM, AND CONSTRUCTING A STATE-OF-THE-ART MEDICAL AND EDUCATIONAL FACILITY ON OUR MAIN CAMPUS IN THE NEW YORK CITY BOROUGH OF QUEENS, WILL ALLOW US TO EDUCATE THE NEXT GENERATION OF HEALTH CARE PROVIDERS IN A MODEL THAT EMBRACES THE UNIVERSITY’S MISSION OF PROVIDING A QUALITY EDUCATION IN AN ENVIRONMENT THAT IS CATHOLIC, VINCENTIAN, AND METROPOLITAN. ACCORDING TO THE U.S. BUREAU OF LABOR STATISTICS, EMPLOYMENT OF REGISTERED NURSES IS PROJECTED TO GROW 9 PERCENT FROM 2020 TO 20301, OUTPACING THE AVERAGE OF NEARLY ALL OTHER OCCUPATIONS. GROWTH WILL OCCUR FOR A NUMBER OF REASONS, INCLUDING AN INCREASED EMPHASIS ON PREVENTIVE CARE; GROWING RATES OF CHRONIC CONDITIONS SUCH AS DIABETES AND OBESITY; AND DEMAND FOR HEALTHCARE SERVICES FROM THE BABY-BOOM POPULATION AS THEY LIVE LONGER AND MORE ACTIVE LIVES. NEW YORK STATE HAS THE THIRD HIGHEST EMPLOYMENT LEVEL FOR REGISTERED NURSES IN THE UNITED STATES, RANKING BEHIND ONLY CALIFORNIA AND TEXAS2. THE NEW YORK CITY METROPOLITAN AREA – THE UNIVERSITY’S HOME SINCE 1929 – EMPLOYS THE MOST REGISTERED NURSES IN THE ENTIRE COUNTRY3. ADDING A BACHELOR OF SCIENCE IN NURSING TO THE UNIVERSITY’S EXISTING SUITE OF COMPREHENSIVE EDUCATIONAL PROGRAMS FOR THE HEALTH CARE INDUSTRY IS A NATURAL PROGRESSION. GRADUATES OF OUR PROPOSED BACHELOR OF SCIENCE IN NURSING PROGRAM WILL BE ABLE TO ENTER METROPOLITAN, UNDERSERVED, AND UNDERDEVELOPED COMMUNITIES LOCALLY AND INTERNATIONALLY WITH THE KNOWLEDGE OF NURSING AND COMPETENCIES IN LIBERAL ARTS AND SCIENCES. THE PROGRAM IS DESIGNED TO DEVELOP STUDENTS INTO VERSATILE GRADUATES WHO CAN CONTRIBUTE TO A COMPLEX MODERN SOCIETY UNDERSCORED WITH THE VINCENTIAN VALUES LEARNED DURING THEIR COURSE OF STUDY AT THE UNIVERSITY. THIS NEW PROGRAM WILL PREPARE STUDENTS TO SEAMLESSLY TRANSITION INTO THE HEALTHCARE INDUSTRY AS REGISTERED NURSES – KEY MEMBERS OF THE CLINICAL TEAM. THE PROPOSED SCOPE OF WORK INCLUDES CLASSROOMS, LABORATORIES, OFFICE SPACE, STUDENT SERVICES, COLLABORATIVE SPACES AND LARGE AUDITORIUM ON FLOORS 1 THROUGH 4 (A TOTAL OF 90,000 SQ. FT.). THE PROPOSED NEW HEALTH SCIENCE CENTER IS ESTIMATED TO COST $106 MILLION. THIS COST EXCLUDES ALL PERSONNEL EXPENSES, CLINICAL SUPPLIES, LABORATORY SUPPLIES, AND INSTRUCTIONAL SUPPLIES. THE WORK HAS BEGUN STARTING FOURTH QUARTER OF 2021 AND IS EXPECTED TO BE COMPLETED BY THE SECOND QUARTER 2024. WE PROJECT THE BUILDING TO BE READY FOR OCCUPANCY AND AVAILABLE FOR STUDENTS AND CLASSES BY FALL 2024. THE HEALTH SCIENCE CENTER WILL PROMOTE INTERPROFESSIONAL EDUCATION AMONGST ALL THE HEALTH SCIENCE PROGRAMS AND REQUIRE ALL STUDENTS TO LEARN TOGETHER AND WORK AS A TEAM, SIMILAR TO THE REAL-WORLD SITUATION AT ANY CLINICAL SETTING. ADDITIONALLY, THE HEALTH SCIENCE CENTER WILL HOUSE STATE-OF-THE-ART SIMULATION FACILITIES WHERE STUDENTS CAN LEARN AND BENEFIT FROM SIMULATION LEARNING OPPORTUNITIES PRIOR TO THEIR REQUIRED EXPERIENTIAL EDUCATION (COMPLETING THEIR CLINICAL ROTATION REQUIREMENTS AT A CLINICAL SETTING).

IMPACT AID PROGRAM, TITLE VIII, SECTION 8003

STJ STUDENT SUPPORT SERVICES PROGRAM

ESTABLISHING A TRIO SSS PROGRAM AT ST. JOHN FISHER COLLEGE

IMPROVE EXISTING AIRPORT

A ROBERT NOYCE SPATIAL THINKING ACADEMY FOR PREPARING EFFECTIVE K-12 STEM TEACHERS

RESERVE RELIEF CANAL

EWP PROJECT 5055, MS, ST JOHN THE BAPTIST PARISH, DSR 22-02-22-5055-007 TO -012 AND 22-06-22-5055-503 TO -506, DEBRIS REMOVAL DUE TO HURRICANE IDA,

PUBLIC HOUSING CAPITAL FUND

IMPROVE EXISTING AIRPORT

STUDENT SUPPORT SERVICES PROGRAM

RONALD E. MCNAIR PROGRAM

IMPACT AID PROGRAM TITLE VIII SECTION 8003

ST. JOHNS UNIVERSITY UPWARD BOUND PROGRAM

NURSING WORKFORCE DIVERSITY

CARES ACT INSTITUTION GRANT

YOUTH BUILD

SJC APPLICATION FOR INSTITUTIONAL RELIEF FUNDS

DOMESTIC WATER GRANTS - REGULAR

IMPACT AID PROGRAM TITLE VIII SECTION 8003 AND SECTION 8007(A)

IMPACT AID PROGRAM TITLE VIII SECTION 8003

MCNAIR SCHOLARS PROGRAM

EMERG/DISASTER RESERVE

2009 ARRA - ADMIN-MAITENANCE FACILI

RONALD E. MCNAIR POSTBACCALAUREATE ACHIEVEMENT

WE THE PEOPLE ENDOWMENT AT ST. JOHN'S COLLEGE, ANNAPOLIS, MARYLAND

LIBRARIANS FOR THE 21ST CENTURY

RONALD E. MCNAIR POST-BACCALAUREATE ACHIEVEMENT

TELEMEDICINE GRANT

PILOT PROGRAM FOR COURSE MATERIALS RENTAL (PPCMR)

2013 SECTION 5307 CAPITAL AND OPERA

ASSISTANCE TO FIREFIGHTERS GRANT

PURPOSE: THE PUBLIC HOUSING CAPITAL FUND PROGRAM (CFP) WAS CREATED BY AN AMENDMENT TO THE 1937 ACT BY THE QUALITY HOUSING AND WORK RESPONSIBILITY ACT (QHWRA) IN 1998 (ADDING SECTION 9(D) TO THE 1937 ACT MERGING PREVIOUS MODERNIZATION AND DEVELOPMENT PROGRAMS). THE CFP PROVIDES FINANCIAL ASSISTANCE IN THE FORM OF GRANTS TO APPROXIMATELY 2,770 PUBLIC HOUSING AGENCIES (PHAS), SERVING NEARLY ONE MILLION UNITS, IN ALL 50 STATES AND TERRITORIES, TO CARRY OUT CAPITAL AND MANAGEMENT ACTIVITIES INCLUDING THOSE LISTED IN SECTION 9(D)(1) OF THE UNITED STATES HOUSING ACT OF 1937 (1937 ACT). THE MAIN PURPOSE OF THE CFP FORMULA GRANT IS TO FUND PUBLIC HOUSING MODERNIZATION, DEVELOPMENT, MANAGEMENT IMPROVEMENTS, AND THE OTHER ELIGIBLE ACTIVITIES DESCRIBED IN 24 CFR PART 905. ADDITIONAL INFORMATION ON THE PUBLIC HOUSING CAPITAL FUND IS LOCATED ON THE OFFICE OF CAPITAL IMPROVEMENTS WEBSITE: OFFICE OF CAPITAL IMPROVEMENTS | HUD.GOV / U.S. DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT (HUD) ADDITIONAL INFORMATION ON PUBLIC HOUSING FUNDING CAN BE FOUND BY ACCESSING THE WEBSITE BELOW AND REVIEWING THE PUBLIC HOUSING DASHBOARD LINKED UNDER THE “DATA DASHBOARD AND ANALYTICS”. PUBLIC HOUSING | HUD.GOV / U.S. DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT (HUD); ACTIVITIES TO BE PERFORMED: THE PHAS RECEIVE FEDERAL FUNDS FROM THE U.S. DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT (HUD) TO ADMINISTER THE PUBLIC HOUSING FUND. PUBLIC HOUSING CAPITAL FUNDS MAY ONLY BE USED FOR ACTIVITIES THAT ARE DESCRIBED AS ELIGIBLE ACTIVITIES IN 24 CFR 905.200 AND ARE EITHER SPECIFIED IN AN APPROVED 5-YEAR ACTION PLAN OR APPROVED BY HUD FOR EMERGENCY WORK OR WORK NEEDED BECAUSE OF A NON-PRESIDENTIALLY DECLARED NATURAL DISASTER. PUBLIC HOUSING DEVELOPMENT, MODERNIZATION, AND FINANCING ARE THE MAJOR ACTIVITIES TO BE PERFORMED. DEVELOPMENT IS ACTIVITIES AND RELATED COSTS THAT ADD TO (OR SIGNIFICANTLY RECONFIGURE) PUBLIC HOUSING UNITS IN A PHA’S INVENTORY, INCLUDING CONSTRUCTION AND ACQUISITION OF ADDITIONAL PUBLIC HOUSING UNITS, WITH OR WITHOUT REHABILITATION, AND ANY-AND-ALL UNDERTAKINGS NECESSARY FOR PLANNING, DESIGN, FINANCING, LAND ACQUISITION, DEMOLITION, CONSTRUCTION, OR EQUIPMENT OF PUBLIC HOUSING UNITS, AND RELATED BUILDINGS, FACILITIES, AND/OR APPURTENANCES (I.E., NON-DWELLING FACILITIES/SPACES). DEVELOPMENT ALSO INCLUDES ANY MIXED-FINANCE MODERNIZATION, ALL RELEVANT MODERNIZATION USES (OTHER THAN MANAGEMENT IMPROVEMENTS), FINANCING USES, AND DEVELOPMENT OF NON-DWELLING SPACE WHERE SUCH SPACE IS NEEDED TO ADMINISTER, AND IS OF DIRECT BENEFIT TO A PUBLIC HOUSING PROJECT (I.E. HOUSING DEVELOPED, ACQUIRED, OR ASSISTED BY A PHA UNDER THE 1937 ACT, AND THE IMPROVEMENT OF ANY SUCH HOUSING), INCLUDING THE RESIDENTS. FINANCING DEBT AND FINANCING COSTS (E.G., ORIGINATION FEES, INTEREST) INCURRED BY A PHA FOR DEVELOPMENT OR MODERNIZATION OF PUBLIC HOUSING PROJECTS, INCLUDING MIXED-FINANCE DEVELOPMENT, THE CAPITAL FUND FINANCING PROGRAM (CFFP), AND ANY OTHER USE AUTHORIZED UNDER SECTION 30 OF THE 1937 ACT. MODERNIZATION INCLUDES ALL ELIGIBLE ACTIVITIES EXCEPT FOR DEVELOPMENT AND FINANCING. PHYSICAL WORK IS A MAJOR ACTIVITY AND IS WORK THAT IS DONE ON THE PHYSICAL STRUCTURES, SITE, AND GROUNDS OF A PUBLIC HOUSING PROPERTY OR STRUCTURE. MAJOR PHYSICAL ACTIVITIES INCLUDE DEMOLITION, RECONFIGURATION, EMERGENCY ACTIVITIES, ENERGY EFFICIENCY, NON-ROUTINE MAINTENANCE, PLANNED CODE COMPLIANCE, AND VACANCY REDUCTION. THE MEASURABLE OUTCOME OF THIS GRANT IS THAT HUD WILL BE ABLE TO TRACK THE AMOUNT OF DOLLARS SPENT ON IMPROVEMENTS TO THE STRUCTURES, UNITS, COMMON AREAS, UTILITIES, AND OTHER ELIGIBLE ACTIVITIES. ; EXPECTED OUTCOMES: THE EXPECTED OUTCOMES FOR PUBLIC HOUSING CAPITAL FUNDS OF APPROXIMATELY $3.2 BILLION WILL BE PUT INTO THE DEVELOPMENT, MODERNIZATION, AND FINANCING OF NEARLY 1 MILLION PUBLIC HOUSING UNITS ACROSS ALL 50 STATES AND TERRITORIES. THE PUBLIC HOUSING UNITS ARE UPDATED TO BE DECENT, SAFE, SANITARY AND TO COMPLY WITH FEDERAL HOUSING STANDARDS. PHAS CAN ALSO USE A PORTION OF THE CAPITAL FUNDING FOR MANAGEMENT IMPROVEMENTS OR OPERATING ACTIVITIES INCLUDING SAFETY AND SECURITY COSTS.; INTENDED BENEFICIARIES: THE INTENDED BENEFICIARIES FOR PUBLIC HOUSING CAPITAL FUNDS ARE THE LOW-INCOME PUBLIC HOUSING RESIDENTS.; SUBRECIPIENT ACTIVITIES: THE RECIPIENT DOES NOT INTEND TO SUBAWARD FUNDS.

PERFORM FUNDING SYS

SJC APPLICATION FOR EMERGENCY RELIEF FUNDS PER THE CARES ACT

2014 SECTION 5307 CAPITAL AND OPERA

DECIPHERING THE NEURAL MECHANISMS OF MUSIC PROCESSING IN THE DEVELOPING BRAIN: A MULTI-FEATURE AND MULTI-CULTURAL COMPARISON - PROJECT SUMMARY MUSIC TRAINING HAS LONG BEEN USED AS A TREATMENT TO ENHANCE NEURAL FUNCTION AND BEHAVIORAL OUTCOMES IN CLINICAL POPULATIONS. THERE IS AN EXTENSIVE LITERATURE DESCRIBING HOW MUSIC-TRAINING AND TONAL LANGUAGE LEARNING ALTERS THE BRAIN AND BEHAVIOR IN HEALTHY ADULT POPULATIONS. ONE IMPORTANT UNRESOLVED ISSUE IS HOW MUSIC EXPERIENCE AND LANGUAGE EXPERIENCE INTERACT IN THE DEVELOPING BRAIN. UNDERSTANDING HOW AND TO WHAT EXTENT MUSIC AND LANGUAGE EXPERIENCE MODULATE CORTICAL DYNAMICS FOR BRAIN FUNCTIONS (E.G., MUSIC AND SPEECH PROCESSING) WILL OPEN A CRUCIAL DOOR TO TREAT A MYRIAD OF NEUROLOGICAL CONDITIONS WITH AN AUDITORY OR LANGUAGE BASE. THE LONG-TERM OVERARCHING GOAL OF THIS PROJECT IS TO UNCOVER THE CAUSAL RELATIONSHIP BETWEEN BRAIN NETWORKS AND BEHAVIORAL ASPECTS OF MUSIC SENSITIVITY IN THE DEVELOPING BRAIN. THIS FIRST PROJECT PROPOSES TO APPLY A COMBINATION OF A MUSIC NEUROPHYSIOLOGICAL PARADIGM, A LEXICAL TONE NEUROPHYSIOLOGICAL PARADIGM AND BEHAVIORAL MEASURES TO UNCOVER THE COMPLEX INTERACTION BETWEEN MUSIC AND LEXICAL TONE PROCESSING IN THE DEVELOPING BRAIN. THE THREE SPECIFIC AIMS ARE: 1) TO DETERMINE THE CORTICAL MATURATIONAL TRAJECTORIES OF AUDITORY PROCESSING IN TERMS OF SIX MAIN MUSIC FEATURES (RHYTHM, INTENSITY, LOCATION, SLIDE, PITCH, AND TIMBRE) IN 5-10 YEAR OLD CHILDREN. EVENT-RELATED POTENTIAL (ERP) RESPONSES WILL BE COMPARED ACROSS AGE GROUPS. A MULTI-FEATURE MUSIC ODDBALL PARADIGM THAT INCLUDES SIX TYPES OF FEATURE CHANGES WILL BE USED. SIGNIFICANCE: THIS AIM IS ESSENTIAL FOR EXAMINING BRAIN DEVELOPMENTAL PLASTICITY FOR THE PROCESSING OF DIFFERENT MUSIC FEATURES. 2) TO DETERMINE WHETHER EARLY MUSIC TRAINING, TONAL LANGUAGE, BILINGUAL LANGUAGE EXPERIENCE AND DIFFERENT ENGLISH DIALECTS MODULATE CORTICAL SENSITIVITY TO THE ABOVE-MENTIONED SIX MAIN MUSIC FEATURES. THE ERP RESPONSES WILL BE COMPARED ACROSS MONOLINGUAL-BILINGUAL, TONAL-NONTONAL LANGUAGE, MAINSTREAM AMERICAN ENGLISH DIALECT – AFRICAN AMERICAN ENGLISH DIALECT GROUPS (MONOLINGUAL ENGLISH WITH MAINSTREAM AMERICAN ENGLISH DIALECT WITH AND WITHOUT MUSIC TRAINING, MONOLINGUAL ENGLISH WITH AFRICAN AMERICAN ENGLISH DIALECT, BILINGUAL SPANISH- ENGLISH AND BILINGUAL MANDARIN-ENGLISH). SIGNIFICANCE: THESE COMPARISONS ARE IMPORTANT BECAUSE IT WILL, FOR THE FIRST TIME, REVEAL THE INTRICATE RELATIONSHIP BETWEEN DIALECTAL EXPERIENCE, LEXICAL TONE DEVELOPMENT, BILINGUAL DEVELOPMENT AND BRAIN DEVELOPMENT FOR MUSIC PROCESSING AT THE CORTICAL LEVEL. 3) TO DETERMINE WHETHER, AND TO WHAT EXTENT, EARLY MUSIC EXPERIENCE AND LANGUAGE EXPERIENCE MODULATE CORTICAL SENSITIVITY TO LEXICAL TONE PROCESSING. THE ERP RESPONSES TO LEXICAL TONE CONTRAST WILL BE COMPARED ACROSS THE ABOVE-MENTIONED GROUPS OF CHILDREN. SIGNIFICANCE: THESE COMPARISONS ARE IMPORTANT BECAUSE IT WILL SHED LIGHT ON THE RELATIONSHIP BETWEEN EARLY MUSIC TRAINING AND THE NEURAL REPRESENTATIONS FOR SPEECH PROCESSING.

PUBLIC HOUSING CAPITAL FUND

STUDENT SUPPORT SERVICES PROGRAM

ADVANCED NURSING EDUCATION GRANTS

DLT OPIOID GRANTS

FISHER SCHOLARS FOR RURAL SCHOOLS (FISCHRS)

IMPROVE EXISTING AIRPORT

PUBLIC HOUSING CAPITAL FUND

PERFORM FUNDING SYS

EWP PROJECT 5055, LA, ST JOHN THE BAPTIST PARISH, DSRS 22-02-22-5055-001TO -006 AND 22-06-22-5055-500 TO -502, DEBRIS REMOVAL DUE TO HURRICANEIDA, INFRASTRUCTURE INVESTMENT AND JOBS ACT (IIJA)

CAREER: ON THE BRINK OF APOSEMATISM -- INTERMEDIATE STATES ON THE EVOLUTION OF ALKALOID SEQUESTRATION AND COLOR PRODUCTION MECHANISMS IN DENDROBATID FROGS -THIS PROJECT WILL STUDY THE ORIGINS OF APOSEMATISM AS A DEFENSIVE STRATEGY LINKING TOXIC CHEMICALS AND WARNING SIGNALS. THIS COMPLEX TRAIT IS THOUGHT TO HAVE STARTED IN CRYPTIC ANCESTORS AND EVOLVED THROUGH INTERMEDIATE STAGES TOWARD AN OPTIMAL DEFENSE STRATEGY. APOSEMATIC POISON FROGS (DENDROBATIDAE) ARE WELL-STUDIED, AND THESE AMPHIBIANS DISPLAY AN ARRAY OF COLORS (REDS, BLUES, AND YELLOWS) THAT ADVERTISE THEIR SKIN ALKALOIDS OBTAINED FROM THEIR DIET. IN CONTRAST, THEIR ANCESTORS ARE LESS WELL-UNDERSTOOD BUT SIMILAR TO PRESENT-DAY DENDROBATIDS THAT ARE NON-APOSEMATIC, WHICH INCLUDE TWO-THIRDS OF THE KNOWN SPECIES IN THIS FAMILY OF AMPHIBIANS. THESE FROGS ARE ASSUMED TO BE TOXIN-FREE, BROWN OR BLACK IN COLOR, AND TO FOLLOW A CAMOUFLAGE-BASED DEFENSE. WE PLAN TO STUDY THESE ORGANISMS TO EXPLAIN HOW APOSEMATISM EVOLVED IN THE FIRST PLACE. TO INVESTIGATE THIS, WE WILL COMPARE THE SKIN PROFILES OF APOSEMATIC AND NON-APOSEMATIC SPECIES AND IDENTIFY EVOLUTIONARY SIGNATURES IN DENDROBATID LINEAGES CONSIDERED NON-APOSEMATIC AS INTERMEDIATE STAGES TOWARD APOSEMATISM. THIS INTEGRATED APPROACH COMBINES BIOCHEMISTRY, GENETICS, AND EVOLUTIONARY ANALYSES. OUR PROJECT ALSO EMPHASIZES THE EDUCATION OF TEACHERS WITH SEVERAL OUTREACH INITIATIVES THAT ENGAGE PARTICIPANTS AT ALL LEVELS AND THAT ARE OPEN TO ALL AMERICANS FROM HIGH SCHOOL TO COLLEGE STUDENTS AND BEYOND. HANDS-ON WORKSHOPS WILL COVER PHYLOGENETICS, GENOMICS, CHEMICAL ANALYSIS, AND BIOINFORMATICS, SUPPORTED BY ONLINE COURSES AND OPEN-ACCESS DATA RESOURCES. BY LINKING CUTTING-EDGE RESEARCH WITH IMMERSIVE TRAINING, OUR PROJECT AIMS TO ADVANCE THE BROAD UNDERSTANDING OF APOSEMATISM DURING ITS EARLY STAGES. APOSEMATISM IS PREDICTED TO EVOLVE VIA INTERMEDIATE PHENOTYPES FROM NON-APOSEMATIC ANCESTORS THAT LACK DEFENSES AND WARNING SIGNALS. CHARACTERIZING THESE INTERMEDIATE FORMS IS KEY TO UNDERSTANDING HOW COMPLEX PHENOTYPES EMERGE AND THEN HOW THEY ARE MAINTAINED, REINFORCED, AND HAVE BECOME SPECIALIZED. HOWEVER, INTERMEDIATE FORMS, BY THEIR NATURE OF BEING TRANSIENT, ARE LESS STUDIED THAN ARE THOSE ALREADY AT SELECTIVE OPTIMA AND THESE INTERMEDIATE FORMS ARE OFTEN IGNORED WHEN MECHANISMS DEFINING APOSEMATISM ARE BEING STUDIED. DENDROBATID FROGS PROVIDE A FOCAL GROUP WHERE INTERMEDIATE FORMS ARE COMMON BEFORE APOSEMATISM, AND MANY TAXA SERVE AS LIVING EXAMPLES PRECEDING AN APOSEMATIC OPTIMUM. IN THIS PROJECT, WE WILL PERFORM COMPARATIVE BIOCHEMICAL PROFILING OF SKIN ALKALOIDS AND PIGMENTS ALONGSIDE HISTOLOGICAL ANALYSES ACROSS APOSEMATIC, NON-APOSEMATIC, AND OUTGROUP SPECIES; INTEGRATE COMPARATIVE TRANSCRIPTOMICS AND GENOMICS TO IDENTIFY CANDIDATE GENES AND CIS-REGULATORY ELEMENTS UNDERLYING THE APOSEMATIC PHENOTYPE; AND MAP SIGNATURES OF POSITIVE SELECTION AND ADAPTIVE SHIFTS IN THESE LOCI ON A ROBUST DENDROBATID PHYLOGENY TO INFER STEPWISE GENETIC CHANGES LEADING TO THE FULL-APOSEMATIC PHENOTYPE. THIS MULTIPRONGED FRAMEWORK WILL RESOLVE THE SEQUENCE OF MOLECULAR AND PHENOTYPIC INNOVATIONS THAT CULMINATED IN APOSEMATISM AS AN OPTIMAL ANTIPREDATOR STRATEGY. DURING THIS PROJECT, WE ANTICIPATE THE DEVELOPMENT OF BROADLY APPLICABLE TOOLS FOR INVESTIGATING THE ORIGINS OF APOSEMATISM IN OTHER TAXA WITH NON-APOSEMATIC CLOSE RELATIVES SUCH AS BUTTERFLIES, SNAKES, AND OTHER GROUPS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

ST. JOHNS UNIVERSITY SBIRT STUDENT TRAINING

CARES STUDENT EMERGENCY GRANT

IDENTIFYING ACOUSTIC-LEVEL AND LANGUAGE-SPECIFIC SENSORY PROCESSING MECHANISMS - SPEECH PERCEPTION IS MODULATED BY EXPERIENCES WITH NATIVE LANGUAGE PHONOTACTIC PATTERNS. SENSORY PROCESSING OF SPEECH IS FUNDAMENTAL TO PERCEPTION, LANGUAGE LEARNING, AND LANGUAGE COMPREHENSION HOWEVER MUCH IS UNKNOWN ABOUT HOW NEURAL SIGNALS BECOME LANGUAGE-SPECIFIC WITHIN THE CORTICAL INFORMATION STREAM. PRELIMINARY EVIDENCE SUGGESTS THAT LANGUAGE EXPERIENCE WITH PHONOTACTIC PATTERNS MODULATES ACOUSTIC-LEVEL SENSORY PROCESSING AT EARLY CORTICAL STAGES (<150 MS) THROUGH FEEDBACK WITHIN THE LOW FREQUENCY BANDS OF THE ELECTROENCEPHALOGRAM (EEG). HOWEVER, THERE ARE CONFLICTING REPORTS ON THE TIMING OF THE MODULATORY EFFECTS, AND FEW, IF ANY, CROSS-LINGUISTIC INVESTIGATIONS OF NATIVE AND NON-NATIVE PHONOTACTIC PATTERNS THAT EXAMINE THE DIRECTION OF INFORMATION FLOW WITHIN CORTICAL NETWORKS. FOR THIS PROJECT, WE WILL ANALYZE 96 EEG DATASETS, PREVIOUSLY OBTAINED FROM 24 NATIVE POLISH AND 24 NATIVE ENGLISH-SPEAKING ADULTS AS THEY LISTENED TO SAME AND DIFFERENT SPOKEN NONWORD PAIRS DURING TWO LISTENING CONDITIONS, AN ATTEND AND PASSIVE CONDITION. NONWORDS WITHIN THE PAIRS CONTAINED THE ONSET SEQUENCES /PT/, /PT/, /ST/, AND /ST/ THAT OCCUR IN THE POLISH AND ENGLISH LANGUAGES, EXCEPT FOR /PT/, WHICH NEVER OCCURS IN ENGLISH IN THE WORD ONSET POSITION. ANALYSIS OF THIS DATASET WILL TEST THE HYPOTHESIS THAT LANGUAGE-SPECIFIC SENSORY PROCESSING OCCURS EARLY WITHIN THE CORTICAL INFORMATION STREAM (<150 MS) THROUGH INFORMATION FLOW DIRECTED TO PHONOLOGICAL PROCESSING REGIONS IN AUDITORY CORTEX. MULTIPLE METHODS OF ANALYSIS INCLUDING AEPS, MEASURES OF TIME-FREQUENCY FROM BRAIN SOURCE-LEVEL CHANNELS, CURRENT SOURCE DENSITY, AND MEASURES OF BRAIN CONNECTIVITY, INCLUDING COHERENCE AND GRANGER CAUSALITY-BASED CONNECTIVITY WILL BE USED TO CARRY OUT THE SPECIFIC AIMS. AIM 1 WILL DETERMINE WHETHER SENSORY PROCESSING OF SPOKEN NONWORDS IS LANGUAGE-SPECIFIC WITHIN THE CONTEXT OF SELECTIVE ATTENTION AT EARLY CORTICAL STAGES. AIM 2 WILL EVALUATE WHETHER SENSORY PROCESSING OF SPOKEN NONWORDS IS LANGUAGE-SPECIFIC WITHIN THE CONTEXT OF REPEATED PHONOLOGICAL SEQUENCES AT EARLY CORTICAL STAGES. AIM 3 WILL DETERMINE THE SPATIAL DISTRIBUTION OF LANGUAGE-SPECIFIC ACTIVITY AND THE DIRECTION OF INFORMATION FLOW DURING SENSORY PROCESSING OF NATIVE AND NON- NATIVE PHONOTACTIC PATTERNS AND WITHIN THE CONTEXTS OF ATTENTION AND REPETITION SUPPRESSION. THE OUTCOMES WILL CLARIFY SENSORY PROCESSING MECHANISMS OF SPEECH PERCEPTION.

CONTINUUM OF CARE PROGRAM

PURCHASE OF CNC ROUTER, PULSE WELDERS, AIR COMPRESSORS

PURPOSE: THE CONTINUUM OF CARE (COC) PROGRAM IS DESIGNED TO PROMOTE COMMUNITY-WIDE COMMITMENT TO THE GOAL OF ENDING HOMELESSNESS; PROVIDE FUNDING FOR EFFORTS BY NONPROFIT PROVIDERS, STATES, AND LOCAL GOVERNMENTS TO QUICKLY HOUSE HOMELESS INDIVIDUALS AND FAMILIES WHILE MINIMIZING THE TRAUMA AND DISLOCATION CAUSED TO HOMELESS INDIVIDUALS, FAMILIES, AND COMMUNITIES BY HOMELESSNESS; PROMOTE ACCESS TO AND EFFECTIVE UTILIZATION OF MAINSTREAM PROGRAMS BY HOMELESS INDIVIDUALS AND FAMILIES; AND OPTIMIZE SELF-SUFFICIENCY AMONG INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS. THE MOST RECENT COC AWARD ANNOUNCEMENT LISTING AWARDS BY STATE AND COC IS ACCESSIBLE AT HTTPS://WWW.HUD.GOV/PROGRAM_OFFICES/COMM_PLANNING/COC/AWARDS. SELECT THE LINK UNDER THE FUNDING AND AWARD INFORMATION SECTION FOR THE APPROPRIATE FISCAL YEAR.; ACTIVITIES TO BE PERFORMED: CONTINUUM OF CARE PROGRAM FUNDS MAY BE USED TO PAY FOR THE ELIGIBLE COSTS USED TO ESTABLISH AND OPERATE PROJECTS UNDER FIVE PROGRAM COMPONENTS: (1) PERMANENT HOUSING, WHICH INCLUDES PERMANENT SUPPORTIVE HOUSING FOR PERSONS WITH DISABILITIES, AND RAPID REHOUSING; (2) TRANSITIONAL HOUSING; (3) SUPPORTIVE SERVICES ONLY; (4) HOMELESS MANAGEMENT INFORMATION SYSTEMS (HMIS), AND (5) IN SOME CASES, HOMELESSNESS PREVENTION. THIRTEEN TYPES OF ASSISTANCE MAY BE PROVIDED THROUGH THE CONTINUUM OF CARE (COC) PROGRAM: (1) COC PLANNING ACTIVITIES/COSTS FOR DESIGNING AND CARRYING OUT A COLLABORATIVE PROCESS FOR THE DEVELOPMENT OF AN APPLICATION TO HUD; (2) UNITED FUNDING AGENCY (UFA) COSTS FOR FISCAL CONTROL AND ACCOUNTING NECESSARY TO ASSURE THE PROPER DISBURSAL OF, AND ACCOUNTING FOR, FEDERAL FUNDS AWARDED TO SUBRECIPIENTS UNDER THE CONTINUUM OF CARE PROGRAM, (3) ACQUISITION OF REAL PROPERTY (INCLUDING STRUCTURES) FOR USE IN THE PROVISION OF HOUSING OR SUPPORTIVE SERVICES; (4) REHABILITATION OF STRUCTURES TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (5) NEW CONSTRUCTION, INCLUDING THE BUILDING OF A NEW STRUCTURE OR BUILDING AN ADDITION TO AN EXISTING STRUCTURE FOR USE AS SUPPORTIVE HOUSING; (6) LEASING OF A STRUCTURE OR STRUCTURES, OR PORTIONS THEREOF, TO PROVIDE HOUSING OR SUPPORTIVE SERVICES; (7) RENTAL ASSISTANCE, WHICH MAY BE SHORT-TERM, MEDIUM-TERM, OR LONG-TERM, AS WELL AS TENANT-BASED, PROJECT-BASED, OR SPONSOR-BASED, FOR TRANSITIONAL OR PERMANENT HOUSING; (8) SUPPORTIVE SERVICES TO ASSIST PROGRAM PARTICIPANTS OBTAIN AND MAINTAIN HOUSING; (9) OPERATING COSTS OF SUPPORTIVE HOUSING; (10) COSTS OF IMPLEMENTING AND OPERATING HMIS; (11) PROJECT ADMINISTRATIVE COSTS; (12) RELOCATION COSTS; AND (13) INDIRECT COSTS IN ACCORDANCE WITH 2 CFR PARTS 200, AS APPLICABLE. IN ADDITION TO USING GRANT FUNDS FOR THE ELIGIBLE COSTS DESCRIBED ABOVE, RECIPIENTS AND SUBRECIPIENTS IN CONTINUUMS OF CARE DESIGNATED AS HIGH PERFORMING COMMUNITIES MAY ALSO USE GRANT FUNDS TO PROVIDE HOUSING RELOCATION AND STABILIZATION SERVICES AND SHORT- AND/OR MEDIUM-TERM RENTAL ASSISTANCE TO INDIVIDUALS AND FAMILIES AT RISK OF HOMELESSNESS AS SET FORTH IN 24 CFR 576.103 AND 24 CFR 576.104, IF NECESSARY TO PREVENT THE INDIVIDUAL OR FAMILY FROM BECOMING HOMELESS. LIMITATION ON USE OF FUNDS: NO ASSISTANCE PROVIDED UNDER PROGRAM (OR ANY STATE OR LOCAL GOVERNMENT FUNDS USED TO SUPPLEMENT THIS ASSISTANCE) MAY BE USED TO REPLACE STATE OR LOCAL FUNDS PREVIOUSLY USED, OR DESIGNATED FOR USE, TO ASSIST HOMELESS PERSONS OR PERSONS AT-RISK OF HOMELESSNESS.; EXPECTED OUTCOMES: DECREASE IN THE NUMBER INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS, MORE SPECIFICALLY USING PERFORMANCE INDICATORS SUCH AS THE LENGTH OF TIME HOMELESS, RETURNS TO HOMELESSNESS OVER TIME, AND EXITS TO PERMANENT HOUSING. COC PERFORMANCE PROFILE REPORTS CAN BE FOUND AT HTTPS://WWW.HUDEXCHANGE.INFO/PROGRAMS/COC/COC-PERFORMANCE-PROFILE-REPORTS/.; INTENDED BENEFICIARIES: INDIVIDUALS AND FAMILIES EXPERIENCING HOMELESSNESS.; SUBRECIPIENT ACTIVITIES: THE SUBRECIPIENT ACTIVITIES ARE UNKNOWN AT THE TIME OF AWARD.

DOMESTIC WATER GRANTS - REGULAR

INTEGRATING SBIRT TRAINING INTO THE CURRICULUM OF THREE HEALTH CARE PROFESSIONAL PROGRAMS

MASTER PLAN STUDY

PROJECT CONNECT - COMMUNITY NETWORKS NEGOTIATING EVALUATIONS AND COUNSELING FOR TRAUMA

COMBINATION OF TUMOR TARGETED THERAPY WITH STROMA MODULATING AGENT FOR PDAC - ABSTRACT PANCREATIC DUCTAL ADENOCARCINOMA (PDAC) IS THE MOST COMMON FORM OF PANCREATIC CANCER. IT IS THE SEVENTH LEADING CAUSE OF CANCER-RELATED MORTALITY WORLDWIDE WITH THE 5-YEAR SURVIVAL RATE STANDING ONLY AT LESS THAN 9%. THREE MAJOR ISSUES IN PANCREATIC TUMOR TREATMENT ARE; POOR AVAILABILITY OF ANTICANCER MOLECULES DUE TO LIMITED BLOOD SUPPLY TO PANCREAS, DEVELOPMENT OF RESISTANT TO FIRST LINE AGENT E.G. GEMCITABINE AND EXTENSIVE FIBROSIS IN TUMOR STROMA. THERE IS AN URGENT NEED FOR A NOVEL AND EFFECTIVE THERAPEUTIC STRATEGY FOR PDAC VIA SIMULTANEOUSLY TARGETING TUMOR AND ITS TUMOR MICROENVIRONMENT. GIVEN THE CENTRAL ROLE OF MYC AS A MEDIATOR OF MULTIPLE CELL PROLIFERATION AND SURVIVAL PATHWAYS, IT IS VERY ESSENTIAL TO TARGET THE PROTO-ONCOGENIC EXPRESSION OF MYC AND CONTROLLING K-RAS MEDIATED DRUG RESISTANCE IN PANCREATIC CANCER. ON ANOTHER SIDE, COLLAGEN TYPE I DENSE EXTRACELLULAR MATRIX OF SOLID TUMOR SEVERELY RESTRICTS THE UPTAKE OF DRUG, MONOCLONAL ANTIBODIES AND NANOTHERAPEUTICS WITHIN PANCREATIC TUMOR. OVEREXPRESSED FOCAL ADHESION KINASE (FAK) IN PANCREATIC CANCER PLAYS ROLE IN ANGIOGENESIS, FIBROSIS AND METASTASIS. WE HYPOTHESIZE THAT ORAL DELIVERY OF FAK INHIBITOR (PND1186) WILL FACILITATE THE UPTAKE AND PENETRATION OF BRD4 PROTAC ALBUMINOSOMES. PROTAC IS NOVEL CLASS OF ANTICANCER MOLECULES WHICH SELECTIVELY DEGRADES THE TARGETED PROTEIN INSTEAD OF MERE INHIBITING IT. PRELIMINARY STUDIES IN OUR LABORATORY REVEALED THAT BRD4 PROTEOLYSIS TARGETING CHIMERA (PROTAC) AND FAK INHIBITOR – PND1186 INHIBIT THE GROWTH OF PANCREATIC CANCER CELLS, AND ENDOTHELIAL CELLS IN 2D AND 3D CULTURE. NANOFORMULATION SHOWED SIGNIFICANT ENHANCEMENT IN SOLUBILITY AND STABILITY. THUS, WE PROPOSE A COMBINATION THERAPY USING A LONG CIRCULATING ALBUMIN COATED NANOLIPOSOME OF BRD4 PROTAC AND PND1186 (ALBUMINOSOMES). THE AIM OF PROPOSED SURE AWARD IS TO EXPLORE THE ALBUMINOSOMES FOR PANCREATIC TUMOR SPECIFIC DELIVERY OF BRD4 PROTAC AND ROLE OF PND IN TUMOR UPTAKE OF NANOPARTICLE. TO ACHIEVE THIS GOAL, WE PROPOSE TWO SPECIFIC AIMS; SPECIFIC AIM 1. SYSTEMATIC CHARACTERIZATION OF ARV-LOADED ALBUMINOSOMES (AANANO) AND PND NANOFORMULATION (PNDNANO). SPECIFIC AIM 2. ANTICANCER EFFICACY, TUMOR UPTAKE AND TOXICITY EVALUATION OF AANANO AND PNDNANO IN HUMAN PANCREATIC TUMOR XENOGRAFT MODEL. CONSIDERING THE SCARCITY OF EFFECTIVE THERAPY FOR PDAC, THE PROPOSED IDEA HAS SIGNIFICANT CLINICAL RELEVANCE.

EWP PROJECT # 5038 IN NEW MADRID COUNTY, MISSOURI. THE ST. JHN LEVEE AND DRAINAGE DISTRICT. SEDIMENT REMOVAL FROM DITCHES DUE TO 2019 FLOOD EVENT.

PUBLIC HOUSING CAPITAL FUND

PUBLIC HOUSING CAPITAL FUND

N,N-DIMETHYLACETAMIDE VAGINAL SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM FOR THE PREVENTION OR PRETERM BIRTH - ABSTRACT BASED ON WORLD HEALTH ORGANIZATION ESTIMATES, THE ANNUAL RATE OF PRETERM BIRTH (PTB) IS GREATER THAN 10% IN THE MAJORITY OF COUNTRIES. PREMATURE BIRTH BEFORE 37 COMPLETED WEEKS OF GESTATION IS THE LEADING CAUSE OF MORTALITY IN THE FIRST YEAR OF LIFE AND IS ASSOCIATED WITH MORBIDITY THAT HAS LIFE-LONG COGNITIVE CONSEQUENCES. ACUTE AND LIFESPAN CARE COSTS ASSOCIATED WITH PRETERM BIRTHS HAVE BROAD AND SUSTAINED EFFECTS ON FAMILIES AND ARE ENORMOUSLY EXPENSIVE FOR SOCIETY. CAUSES OF PTB ARE MULTIFACTORIAL, BUT THE SINGLE MOST COMMON CAUSE OF PTB IS INFLAMMATION. SADLY, THERE IS CURRENTLY NO UNITED STATES FOOD AND DRUG ADMINISTRATION APPROVED DRUG FOR THE PREVENTION OF PTB. ONE OF THE HURDLES IN TRANSLATIONAL RESEARCH AND DRUG DEVELOPMENT IN THIS FIELD IS THE RISK OF DRUG RELATED TOXICITY AFFECTING THE FETUS. SEVERAL YEARS AGO, WE MADE THE FORTUITOUS DISCOVERY THAT THE SAFE PHARMACEUTICAL SOLVENT, N,N-DIMETHYLACETAMIDE (DMA), PREVENTS PTB AND RESCUES PUPS FROM SPONTANEOUS ABORTION IN OUR MOUSE MODEL. FURTHER STUDIES IN OUR LABORATORY REVEALED THAT DMA SUPPRESSES NUCLEAR TRANSLOCATION AND ACTIVATION OF NUCLEAR FACTOR KAPPA B (NF-KB), A TRANSCRIPTION FACTOR THAT REGULATES IMMUNE CELL-MEDIATED INFLAMMATION. IN ADDITION, WE HAVE SHOWN THAT DMA ATTENUATES CYTOKINE SECRETION FROM CULTURED HUMAN TROPHOBLASTS AND FROM HUMAN PLACENTAL EXPLANTS. RECENTLY, OUR LABORATORY HAS TEAMED UP WITH OUR COLLABORATOR’S TO DEVELOP A VAGINAL (PV) SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS), WHICH TAKES ADVANTAGE OF THE FIRST UTERINE/CERVIX PASS EFFECT TO DELIVER DRUGS INTRODUCED INTO THE VAGINAL CAVITY DIRECTLY TO THE CERVIX AND UTERUS, THEREBY MINIMIZING RISK OF SYSTEMIC TOXICITY AND TERATOGENICITY. THE SPECIFIC AIMS OF THE CURRENT PROJECT ARE TO 1) TEST THE EFFECTS OF OUR PV DMA SNEDDS ON HISTOMORPHOLOGY AND INFLAMMATORY RESPONSES IN THE CERVIX IN A MURINE MODEL; 2) DETERMINE THE MOLECULAR MECHANISM WHEREBY DMA INHIBITS NF-KB TRANSCRIPTIONAL ACTIVITY; AND 3) COMPARE TOXIC AND TERATOGENIC EFFECTS OF A DMA SNEDDS TO INTRAPERITONEAL ADMINISTRATION OF DMA. TO ACCOMPLISH THESE AIMS, WE ASSEMBLED A TEAM OF EXPERTS IN PTB, CERVIX HISTOMORPHOLOGY AND DRUG FORMULATION. THIS MULTIDISCIPLINARY TEAM WILL BE WORKING ALONGSIDE OUR STUDENTS, WHO COME FROM A DIVERSE AND UNDERSERVED POPULATION. ALTHOUGH PTB IS A GLOBAL PUBLIC HEALTH PROBLEM, RATES OF PTB ARE SIGNIFICANTLY HIGHER AMONG UNDERSERVED POPULATIONS. THE NOVELTY OF RE-PURPOSING A READILY AVAILABLE AND INEXPENSIVE COMMON DRUG EXCIPIENT TO PREVENT PTB, TOGETHER WITH DESIGNING A VAGINAL FORMULATION THAT CAN BE ADMINISTERED BY PATIENTS REMOTE FROM CLINICS OR HOSPITALS, ADDRESSES A CRITICAL GAP IN THE FIELD OF DRUG DEVELOPMENT FOR PTB.

COMBINED PRIORITY FOR PERSONNEL PREPARATION

DERMAL-EPIDERMAL JUNCTION DISRUPTORS: TOXICODYNAMIC MECHANISMS - PROJECT SUMMARY/ABSTRACT DERMAL-EPIDERMAL JUNCTION (DEJ) DISRUPTORS ARE CUTANEOUS POISONS THAT CAUSE THE EPIDERMIS TO DETACH FROM THE DERMIS, AN EFFECT THAT RESULTS IN SKIN BLISTERING (VESICATION). THE PROTOTYPE DEJ DISRUPTOR IS MECHLORETHAMINE (MEC), A NITROGEN MUSTARD; HOWEVER, THE TOXICODYNAMIC MECHANISMS INVOLVED IN VESICATION BY MEC AND OTHER DEJ DISRUPTORS REMAINS MOSTLY UNDESCRIBED IN THE SCIENTIFIC LITERATURE. THE OVERALL GOAL OF THE WORK PROPOSED HERE IS TO INVESTIGATE THE TOXICODYNAMIC MECHANISMS ASSOCIATED WITH DEJ DISRUPTION. THIS WILL BE ACHIEVED BY STUDYING THE ROLE OF MAST CELL DERIVED MEDIATORS (HISTAMINE AND THE SERINE PROTEASE TRYPTASE), NEUTROPHIL-DERIVED MEDIATORS (MYELOPEROXIDASE, MPO AND MATRIX METALLOPROTEINASE-9, MMP-9) AND KERATINOCYTE-SPECIFIC COLLAGENS (COLLAGEN IV, COL4 AND COLLAGEN XVII, COL17) IN THE RESPONSE OF SKIN TO MEC. IN AIM 1 OF THE PROPOSAL, THE HYPOTHESIS THAT MAST CELL-DERIVED MEDIATORS INFLUENCE DEJ DISRUPTION WILL BE EVALUATED. TO THIS END, MOUSE EAR SKIN WILL BE TOPICALLY EXPOSED TO SALINE (NAÏVE), DIMETHYLSULFOXIDE (DMSO, VEHICLE) OR MEC. ADDITIONAL GROUPS OF MICE WILL BE TREATED 20 MIN PRIOR TO EXPOSURE TO SALINE, VEHICLE OR MEC WITH THE ANTIHISTAMINE DOXEPIN (5% CREAM ADMINISTERED TOPICALLY) OR THE TRYPTASE INHIBITOR LEUPEPTIN (AT TEST DOSES OF 10 OR 30 MG/KG, IP). ALL EAR TISSUES WILL BE HARVESTED AT 2, 8 OR 24 HR AND EITHER FIXED FOR HISTOPATHOLOGIC ANALYSIS OR HOMOGENIZED AND ASSAYED FOR THE PRESENCE OF HISTAMINE VIA ELISA AND TRYPTASE VIA WESTERN BLOTTING. IN AIM 2 OF THE PROPOSAL, WE WILL TEST THE HYPOTHESIS THAT NEUTROPHIL-DERIVED MMP-9 CONTRIBUTES TO DEJ DISRUPTION BY MEC. TO TEST THIS HYPOTHESIS, WE WILL ANALYZE NAÏVE, VEHICLE AND MEC-TREATED MOUSE EAR BIOPSIES FROM WILDTYPE AND MMP9 -/- KNOCKOUT MICE OBTAINED AT 2, 8 OR 24 HR AFTER EXPOSURE FOR THE PRESENCE OF DEJ DISRUPTION USING LIGHT MICROSCOPY AND FOR THE PRESENCE OF MYELOPEROXIDASE, A NEUTROPHIL-SELECTIVE MARKER, USING IMMUNOHISTOCHEMISTRY (IHC). IN AIM 3 OF THE PROPOSAL, WE WILL TEST THE HYPOTHESIS THAT MEC PROMOTES BLISTERING BY INTERFERING AT THE LEVEL OF EPIDERMAL KERATINOCYTES AND AFFECTING THE EXPRESSION OF KEY KERATINOCYTE-EXPRESSED COLLAGENS INVOLVED IN MAINTAINING THE DEJ, NAMELY COL4 AND COL17. TO TEST THIS HYPOTHESIS, WE WILL ANALYZE MOUSE EAR BIOPSIES FROM THE TIME POINTS AND SAMPLES DESCRIBED ABOVE FOR AIM 1 BUT HERE CARRY OUT IHC ON THE FORMALIN-FIXED PARAFFIN EMBEDDED TISSUES TO EVALUATE HOW THE EXPRESSION OF THESE TWO PROTEINS, COL4 AND COL17, CHANGES OVER TIME AFTER FOLLOWING EXPOSURE TO MEC. IN ADDITION, EXPERIMENTS IN AIM 3 WILL UTILIZE HUMAN 3D SKIN CULTURES EXPOSED TO MEC FOR 2, 8 OR 24 HR TO INVESTIGATE EFFECTS ON COL4 AND COL17 PROTEIN EXPRESSION IN HUMAN TISSUES. ALL IN ALL, THE PROPOSAL SEEKS TO INVESTIGATE THREE RELATED YET INDEPENDENT HYPOTHESES THAT WILL SHED NEW LIGHT ON THE TOXICODYNAMIC MECHANISMS USED BY DEJ DISRUPTORS TO CAUSE BLISTERS AND WILL UNCOVER NOVEL TARGETS FOR THE PURPOSE OF REDUCING CHEMICALLY INDUCED CUTANEOUS BLISTERING. THE WORK PROPOSED HERE WILL PROVIDE A BROAD, “WHOLE TISSUE” TOXICODYNAMIC RESPONSE TO INJURY BY MEC AT THE LEVELS OF THE CUTANEOUS MAST CELLS, THE INFILTRATING NEUTROPHILS AND THE EPIDERMAL KERATINOCYTES AND WILL BE COMPLEMENTED BY THE 3D HUMAN SKIN STUDY. MOST IMPORTANTLY, STUDENTS INVOLVED IN THIS PROJECT WILL LEARN A WIDE RANGE OF SKILLS INCLUDING EXPERIMENTAL DESIGN, ANIMAL CARE, ANIMAL DOSING, HISTOLOGY TECHNIQUES, IHC, WESTERN BLOTTING AND HOW TO USE IMAGEJ SOFTWARE TO ASSESS TISSUE PROTEIN EXPRESSION.

PUBLIC HOUSING CAPITAL FUND

SMALL COMMUNITY AIR SERVICE DEVELOPMENT PROGRAM

PUBLIC HOUSING CAPITAL FUND

CAPITAL AND MANAGEMENT ACTIVITIES (FORMULA)

PERFORM FUNDING SYS

ALTERNATIVE SPLICING MODULATES THE ACTIVITY OF CAV3.1, AN ION CHANNEL GENE INVOLVED IN SPINOCEREBELLAR ATAXIA, EPILEPSY, AND AUTISM SPECTRUM DISORDERS. - PROJECT SUMMARY/ABSTRACT THE CENTRAL NERVOUS SYSTEM COMPRISES THE TISSUES AND CELLS WITH THE HIGHEST RATE OF ALTERNATIVE SPLICING IN THE BODY, AND RNA-BINDING PROTEINS PLAY A MAJOR FUNCTIONAL ROLE IN NEURONS. TO BETTER UNDERSTAND THE CONTRIBUTION OF RNA SPLICING TO NERVE CELL BIOLOGY, AND TO HELP ELUCIDATE THE FUNCTION THAT SPLICING PLAYS IN NEURON PHYSIOLOGY AND NEUROLOGIC DISORDERS IT IS NECESSARY TO CHARACTERIZE HOW THE INCLUSION OR SKIPPING OF SPECIFIC EXONS MODULATES THE PHYSIOLOGICAL PROPERTIES OF MOLECULES — SUCH AS ION CHANNELS — THAT ARE CRITICAL FOR NEURONAL FUNCTION, AND TO CHARACTERIZE HOW THESE SPLICING EVENTS ARE REGULATED AT THE CELLULAR AND MOLECULAR LEVEL. OUR LONG-TERM GOAL IS TO UNDERSTAND THE MOLECULAR MECHANISMS REGULATING PROTEIN-RNA NETWORKS THAT CONTROL ALTERNATIVE SPLICING IN THE BRAIN, AND HOW THEY RELATE TO THE BIOLOGY OF NEURONS AND TO DISORDERS OF THE NERVOUS SYSTEM. THE OBJECTIVE OF THIS PROPOSAL IS TO STUDY HOW ALTERNATIVE SPLICING OF CAV3.1, A VOLTAGE-GATED CALCIUM CHANNEL THAT SIGNIFICANTLY CONTRIBUTES TO THE REGULATION OF CELL MEMBRANE EXCITABILITY — PARTICULARLY IN MUSCLE AND NEURONS — AND THAT IS MUTATED IN PATIENTS WITH SPINOCEREBELLAR ATAXIA-42 (SCA42) IS REGULATED IN DIFFERENT NEURON CELL TYPES, AND HOW IT MAY CONTRIBUTES TO THE MODULATION OF CHANNEL ACTIVITY. THE CENTRAL HYPOTHESIS OF THIS PROPOSAL IS THAT NEURONAL CELL TYPE-SPECIFIC ALTERNATIVE SPLICING OF CAV3.1 AT THE C-TERMINUS SHAPES THE PHYSIOLOGICAL PROPERTIES OF THIS VOLTAGE-GATED ION CHANNEL. IN AIM 1 WE WILL TEST THE HYPOTHESIS THAT CAV3.1 ALTERNATIVELY SPLICED EXONS ARE DIFFERENTIALLY EXPRESSED IN DIFFERENT NEURONAL CELL TYPES IN THE BRAIN. TO TACKLE THIS QUESTION, WE HAVE DEVELOPED AN RNASEQ-BASED BIOINFORMATICS PIPELINE THAT WILL ALLOW US TO INTERROGATE DIFFERENTIAL SPLICING BETWEEN NEURONAL SUBCLASSES DEFINED AT DIFFERENT HIERARCHICAL LEVELS. THIS METHODOLOGY WILL NOT ONLY PROVIDE A SNAPSHOT OF THE ALTERNATIVE SPLICING LANDSCAPE OF CAV3.1 IN DIFFERENT NEURONAL SUBCLASSES IN THE BRAIN, BUT IT WILL ALSO ALLOW US TO GENERATE PREDICTIONS ON HOW THESE ALTERNATIVE SPLICING EVENTS ARE REGULATED. IN AIM 2 WE WILL TEST THE HYPOTHESIS THAT ALTERNATIVE SPLICING AT THE C-TERMINUS SIGNIFICANTLY CONTRIBUTES TO THE REGULATION OF THE PHYSIOLOGICAL ACTIVITY OF THIS ION CHANNEL. SINCE SEVERAL DISEASE-ASSOCIATED MUTATIONS IN CAV3.1 MAP TO ALTERNATIVELY SPLICED EXONS, UNDERSTANDING HOW ALTERNATIVE SPLICING MODULATES CHANNEL ACTIVITY IS CRITICAL. SINCE PATIENTS WITH CAV3.1-ASSOCIATED PATHOLOGIES DISPLAY DEFECTS IN CALCIUM CURRENT PROPERTIES, UNDERSTANDING HOW ALTERNATIVE SPLICING MAY MODULATE THE BIOLOGICAL FUNCTIONS OF CAV3.1 AND HOW THIS MODULATION IS REGULATED, MAY HAVE BROAD AND SIGNIFICANT CLINICAL IMPLICATIONS IN SPINOCEREBELLAR ATAXIA, EPILEPSY, AND AUTISM SPECTRUM DISORDERS, AND IT MAY INFORM THE DESIGN OF NOVEL THERAPEUTIC STRATEGIES. MOREOVER, THIS PROJECT WILL PROVIDE BOTH UNDERGRADUATE AND GRADUATE STUDENTS WITH A UNIQUE OPPORTUNITY TO LEARN THE FUNDAMENTALS OF MOLECULAR BIOLOGY AND BIOMEDICAL RESEARCH AND HELP THEM IN THEIR PURSUE OF A CAREER IN THE BIOMEDICAL FIELD.

IMPROVE EXISTING AIRPORT

ADVANCED EDUCATION NURSING TRAINEESHIP

PS07-003, MINORITY HIV/AIDS RESEARCH INITIATIVE (MARI)

2009 SECTION 5307 CAPITAL AND OPERA

2011 SECTION 5307 CAPITAL AND OPERA

REGULATION OF MRNA HOMEOSTASIS BY PD-L1 - ABSTRACT THE GOAL OF THIS PROJECT IS TO IDENTIFY MECHANISMS BY WHICH IMMUNE CHECKPOINT PROGRAMMED DEATH LIGAND 1 (PD-L1) REGULATES MRNA HOMEOSTASIS OF ANTI-APOPTOTIC GENES. AS A CELL SURFACE PROTEIN, PD-L1 INHIBITS T CELL RESPONSES, RESULTING IN IMMUNE ESCAPE. HOWEVER, PD-L1 ALSO HAS IMPORTANT NON-IMMUNE INTRACELLULAR FUNCTIONS THAT ARE MUCH LESS UNDERSTOOD. OUR RECENT STUDIES SHOW THAT IFN INDUCES THE NUCLEAR TRANSLOCATION AND ACCUMULATION OF PD-L1 IN OVARIAN AND PROSTATE CANCER CELLS. IN ADDITION, OUR PRELIMINARY DATA INDICATE THAT SUPPRESSION OF THE IFN-INDUCED PD-L1 EXPRESSION INCREASES APOPTOSIS AND DECREASES MRNA LEVELS OF NFB-DEPENDENT ANTI-APOPTOTIC GENES. BASED ON THOSE FINDINGS, WE WILL TEST THE CENTRAL HYPOTHESIS THAT THE INTRACELLULAR PD-L1 SERVES AS A REGULATOR OF ANTI-APOPTOTIC GENE MRNA HOMEOSTASIS. IN AIM 1, WE WILL DETERMINE WHETHER PD-L1 INCREASES THE LEVELS OF ANTI-APOPTOTIC GENES BY PROMOTING THEIR TRANSCRIPTION, AND/OR WHETHER IT INCREASES STABILITY OF THEIR MRNAS IN OVARIAN AND PROSTATE CANCER CELLS. IN AIM 2, WE WILL DETERMINE WHETHER PD-L1 DIRECTLY BINDS TO THE ANTI-APOPTOTIC GENE PROMOTERS AND FACILITATES THEIR ACETYLATION, AND WE WILL INVESTIGATE WHETHER PD-L1 BINDS THE ANTI-APOPTOTIC MRNAS AND AFFECTS THEIR SUBCELLULAR LOCALIZATION. ALTHOUGH THE PROJECT FOCUSES ON THE NFB-DEPENDENT ANTI-APOPTOTIC GENES, THE RESULTS WILL LIKELY REVEAL GENERAL MECHANISMS BY WHICH PD-L1 REGULATES SYNTHESIS AND/OR STABILITY OF OTHER MRNAS. IMMUNOTHERAPIES TARGETING CELL SURFACE PD-L1 HAVE SHOWN IMPRESSIVE CLINICAL OUTCOMES IN MANY CANCERS; HOWEVER, ONLY A FRACTION OF PATIENTS ACHIEVES DURABLE RESPONSES, HIGHLIGHTING OUR INCOMPLETE UNDERSTANDING OF THE MECHANISMS OF PD-L1 FUNCTIONS. FINDINGS FROM THIS STUDY WILL PROVIDE THE FIRST DATA ON THE MECHANISMS OF HOW PD-L1 REGULATES MRNA HOMEOSTASIS OF ANTI- APOPTOTIC GENES. THIS INFORMATION WILL ADVANCE OUR UNDERSTANDING OF THE INTRACELLULAR, IMMUNE- INDEPENDENT FUNCTIONS OF PD-L1, AND MAY LEAD TO THE DEVELOPMENT OF NOVEL THERAPIES THAT TARGET PD- L1 ANTI-APOPTOTIC FUNCTIONS IN CANCER CELLS. IN ADDITION, THIS R16 SURE PROJECT WILL ENHANCE THE RESEARCH ENVIRONMENT AT ST. JOHN’S UNIVERSITY BY PROVIDING STUDENTS FROM UNDERREPRESENTED BACKGROUNDS WITH NUMEROUS OPPORTUNITIES TO LEARN THE FUNDAMENTALS OF BIOMEDICAL RESEARCH.

PHARMACOLOGICAL AND CHEMICAL APPROACHES TO REPURPOSE AN ANTIEPILEPTIC FOR GLIOBLASTOMA TREATMENT - PROJECT SUMMARY / ABSTRACT GLIOBLASTOMA MULTIFORME (GBM) IS THE MOST AGGRESSIVE PRIMARY BRAIN TUMOR WITH A DISMAL 5-YEAR SURVIVAL RATE (~ 5 %). GBM METASTASIZES TO DIFFERENT BRAIN REGIONS WHICH MAKES SURGICAL RESECTION DIFFICULT. DESPITE RADIATION THERAPY AND CHEMOTHERAPY, THE MEDIAN SURVIVAL TIMELINE IS DIRE AT 15 MONTHS. THE MAJOR CHALLENGES IN GBM THERAPY INCLUDE LATE DIAGNOSIS, METASTASIS, RESISTANCE TO CHEMOTHERAPEUTICS, AND DRUG DELIVERY ISSUES DUE TO BLOOD-BRAIN BARRIER. THUS, EFFORTS TOWARDS DEVELOPING NOVEL PHARMACOTHERAPIES FOR GBM ARE HIGHLY WARRANTED. CANCER CELLS REWIRE THEIR METABOLIC PATHWAYS THAT ARE INTIMATELY LINKED TO ONCOGENES AND TUMOR SUPPRESSOR GENES. THE METABOLIC REPROGRAMMING CONFERS GBM SEVERAL ADVANTAGES IN SURVIVAL, PROLIFERATION, METASTASIS, DRUG RESISTANCE, AND IMMUNE EVASION. IN ADDITION, RECENT RESEARCH IN THE CANCER METABOLISM FIELD HAS REVEALED AN IMPORTANT ‘LACTATE SHUTTLE’ THAT EXPLAINS THE KEY ROLE OF LACTATE TRANSFER FROM SYSTEMIC CIRCULATION INTO TUMOR MICROENVIRONMENT. LACTATE UTILIZATION IS HIGHLY RELEVANT FOR BRAIN TUMORS SUCH AS GBM. OUR LONG-TERM GOAL IS TO PHARMACOLOGICALLY TARGET TUMOR METABOLIC REPROGRAMMING FOR CANCER THERAPY. TOWARDS THAT GOAL, WE SCREENED A NUMBER OF METABOLIC INHIBITORS IN GBM CELLS THAT UNCOVERED EFFECTIVENESS OF AN FDA-APPROVED ANTIEPILEPTIC DRUG STIRIPENTOL WITH ITS PUTATIVE TARGET LACTATE DEHYDROGENASE. THE OBJECTIVE OF THIS STUDY IS TO ELUCIDATE MOLECULAR MECHANISM AND CHANGES IN CANCER BIOLOGY BY STIRIPENTOL TREATMENT IN GBM CELLS AND GBM IN VIVO MODELS. IN ADDITION, WE WILL STUDY STRUCTURE-ACTIVITY RELATIONSHIPS OF NOVEL DERIVATIVES IDENTIFIED FROM STIRIPENTOL SCAFFOLD TO DEVELOP POTENT INHIBITORS. ADDITIONALLY, FORMULATIONS OF STIRIPENTOL AND POTENT LEAD COMPOUNDS WILL BE DEVELOPED AND TESTED IN THE TUMOR XENOGRAFT MODEL OF U87 XENOGRAFTS. OUR RESEARCH WILL OFFER NOVEL INSIGHTS IN THE MECHANISTIC PHARMACOLOGY OF STIRIPENTOL AND CAN LEAD TO THE DEVELOPMENT OF CANDIDATE THERAPEUTICS FOR GBM TREATMENT.

2010 SECTION 5307 CAPITAL AND OPERA

STEM SCHOLARS PROGRAM: DEVELOPING TOMORROW'S LEADERS IN SCIENCE, TECHNOLOGY, ENGINEERING, AND MATHEMATICS

COMMUNITY RESEARCH AND COGNITIVE REFRAMING FOR A COMMUNITY RETAINED IN SCIENCE

2012 SECTION 5307 CAPITAL AND OPERA

PERFORM FUNDING SYS

PUBLIC AND INDIAN HOUSING

TELEHEALTH NETWORK GRANT PROGRAM

PUBLIC AND INDIAN HOUSING

PUBLIC AND INDIAN HOUSING

TO FOSTER EFFICIENCY COMPETITIVE OPERATIONS AND QUALITY SHIP CONSTRUCTION REPAIR AND RECONFIGURATION IN SMALL SHIPYARDS ACROSS THE UNITED STATES IN ADDITION TO FOSTERING EMPLOYEE SKILLS AND ENHANCED PRODUCTIVITY RELATED TO SHIPBUILDING SHIP REPAIR AND ASSOCIATED INDUSTRIES THIS GRANT IS FOR THE PURCHASE AND INSTALLATION OF A GROVE GRT8100 110-TON ROUGH TERRAIN CRANE DELIVERABLES ARE A GROVE GRT8100 110-TON ROUGH TERRAIN CRANE WHICH WILL INCREASE EFFICIENCY IN WITHIN THE SHIPYARD INTENDED BENEFICIARY IS ST JOHNS SHIP BUILDING INC THERE ARE NO SUBRECIPIENT ACTIVITIES

PERFORM FUNDING SYS

PERFORM FUNDING SYS

PUBLIC AND INDIAN HOUSING

RESPOND: REPURPOSING DRUGS FOR RESPIRATORY DISORDERS USING A HYBRID NEURO-SYMBOLIC AI APPROACH - ABSTRACT PULMONARY ARTERIAL HYPERTENSION (PAH) AND IDIOPATHIC PULMONARY FIBROSIS (IPF) ARE SERIOUS, PROGRESSIVE LUNG DISEASES THAT CURRENTLY LACK EFFECTIVE TREATMENTS TARGETING THE ROOT CAUSES OF THE CONDITIONS. PAH IS CAUSED BY HIGH BLOOD PRESSURE IN THE LUNGS THAT CAN LEAD TO HEART FAILURE, WHILE IPF INVOLVES SCARRING IN THE LUNGS THAT WORSENS OVER TIME AND REDUCES BREATHING CAPACITY. THIS PROJECT AIMS TO DISCOVER NEW TREATMENT OPTIONS BY REPURPOSING EXISTING FDA-APPROVED DRUGS USING A NOVEL ARTIFICIAL INTELLIGENCE SYSTEM CALLED RESPOND. RESPOND INTRODUCES NOVEL AI TOOLS THAT CAN ANALYZE LARGE SETS OF BIOMEDICAL DATA SUCH AS DRUG INFORMATION, DISEASE PATHWAYS, AND GENETIC FACTORS TO IDENTIFY DRUGS THAT MAY BE EFFECTIVE AGAINST PAH AND IPF. THE PROJECT FOCUSES ON TARGETING SPECIFIC BIOLOGICAL PATHWAYS KNOWN TO DRIVE THESE DISEASES. PROMISING DRUG CANDIDATES WILL BE TESTED THROUGH LABORATORY EXPERIMENTS AND ANIMAL STUDIES TO EVALUATE THEIR EFFECTIVENESS IN SLOWING DISEASE PROGRESSION. A KEY GOAL OF THIS PROJECT IS TO PROVIDE MEANINGFUL RESEARCH TRAINING OPPORTUNITIES FOR UNDERGRADUATE STUDENTS. STUDENTS WILL BE INVOLVED IN ALL PHASES OF THE RESEARCH, INCLUDING DATA ANALYSIS, EXPERIMENTAL TESTING, AND SCIENTIFIC COMMUNICATION, HELPING TO PREPARE THE NEXT GENERATION OF SCIENTISTS. THE OVERALL GOAL IS TO IMPROVE TREATMENT OPTIONS FOR PATIENTS WITH PAH AND IPF AND TO ESTABLISH A FRAMEWORK FOR USING AI TO ACCELERATE DRUG DISCOVERY IN OTHER COMPLEX DISEASES.

MOLECULAR MECHANISMS OF PROTON CONDUCTANCE AND GATING IN OTOP PROTON CHANNELS - ABSTRACT PROTON CHANNELS PLAY FUNDAMENTAL ROLES IN MAINTAINING PH HOMEOSTASIS, MEMBRANE POTENTIAL REGULATION, AND CELLULAR SIGNALING, AND THEIR DYSFUNCTION CONTRIBUTES TO CANCER PROGRESSION, ISCHEMIC INJURY, METABOLIC IMBALANCE, AND SENSORY DISORDERS. OTOPETRINS (OTOP1–3) REPRESENT A NEWLY IDENTIFIED FAMILY OF EVOLUTIONARILY CONSERVED PROTON-SELECTIVE ION CHANNELS THAT MEDIATE PROTON TRANSPORT ACROSS MEMBRANES IN DIVERSE TISSUES, INCLUDING TASTE RECEPTOR CELLS, VESTIBULAR ORGANS, AND EPITHELIAL CELLS CRITICAL FOR ACID-BASE BALANCE. THE MOLECULAR MECHANISMS THAT GOVERN OTOP CHANNEL CONDUCTANCE AND GATING REMAIN LARGELY UNKNOWN. EACH OTOP SUBUNIT CONTAINS TWO HOMOLOGOUS DOMAINS (N AND C), EACH FORMING A BARREL-LIKE STRUCTURE, AND THE DIMERIC CHANNEL ENCLOSES A CENTRAL, LIPID-FILLED CAVITY THAT IS STRUCTURALLY STABLE BUT LIKELY NONCONDUCTIVE. HOWEVER, WHICH STRUCTURAL PATHWAY CONDUCTS PROTONS AND HOW THE TWO DOMAINS REGULATE GATING REMAIN UNRESOLVED. OUR RECENT STUDIES REVEAL THAT MUTATIONS WITHIN THE INTRASUBUNIT INTERFACE CONVERT PROTON SELECTIVITY TO ANION PERMEABILITY, ESTABLISHING THIS REGION AS THE PRIMARY CONDUCTION PATHWAY, WHILE MUTATIONS IN CONSERVED RESIDUES OF THE N- AND C-PORES ALTER GATING, PRODUCING CATION LEAKS OR BIPHASIC ACTIVATION, IMPLICATING THESE DOMAINS IN GATING REGULATION RATHER THAN CONDUCTANCE. MOREOVER, PUTATIVE MONOMERIC OTOP1 MUTANTS RETAINS ROBUST PROTON CURRENT, SUGGESTING THAT EACH SUBUNIT CAN FUNCTION INDEPENDENTLY. BUILDING ON THESE FINDINGS, THIS PROJECT WILL (1) DEFINE THE PROTON-CONDUCTING PORE AND SELECTIVITY FILTER OF OTOP CHANNELS, (2) DETERMINE HOW THE N- AND C-PORES REGULATE GATING, AND (3) TEST WHETHER AN OTOP1 MONOMER REPRESENTS THE MINIMAL FUNCTIONAL UNIT. UNDERSTANDING OTOP CHANNEL MECHANISMS WILL ADVANCE ION CHANNEL PHYSIOLOGY AND PROVIDE NEW INSIGHTS INTO PROTON TRANSPORT PRINCIPLES ACROSS BIOLOGICAL SYSTEMS. CONDUCTED IN AN UNDERGRADUATE- CENTERED RESEARCH ENVIRONMENT, THIS R15 PROJECT WILL INTEGRATE HIGH-IMPACT MECHANISTIC STUDIES WITH MEANINGFUL STUDENT PARTICIPATION, FOSTERING THE NEXT GENERATION OF BIOMEDICAL SCIENTISTS.

INVESTIGATING THE ROLE OF LIPOCALIN PROSTAGLANDIN D2 SYNTHASE AND ITS METABOLITE PGD2 IN NON-ALCOHOLIC FATTY LIVER DISEASE - PROJECT SUMMARY/ABSTRACT DESPITE NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) BEING THE MOST COMMON CHRONIC LIVER DISEASE WORLDWIDE, MOLECULAR MECHANISMS CONTRIBUTING TO ITS ETIOLOGY AND PROGRESSION ARE STILL UNCLEAR. THIS GAP IN KNOWLEDGE HAS PREVENTED THE UNDERSTANDING OF BASIC BIOLOGY, PATHOGENESIS, AND THE DEVELOPMENT OF NOVEL THERAPEUTICS FOR NAFLD. THERE IS CURRENTLY NO FDA-APPROVED THERAPY FOR NAFLD. A VAST MAJORITY OF PRIOR STUDIES THAT INVESTIGATED NAFLD WERE PERFORMED PRIMARILY ON OBESE MODELS SINCE OBESITY AND NAFLD ARE STRONGLY INTERTWINED. DESPITE THESE STUDIES, THE ROLE OF INSULIN RESISTANCE IN NAFLD IS UNCLEAR. INTERESTINGLY, OUR PRELIMINARY DATA DEMONSTRATED THAT L-PGDS KNOCKOUT MICE EXHIBITED A NAFLD PHENOTYPE ALONG WITH SIGNIFICANT INSULIN RESISTANCE AND WEIGHT GAIN ON HIGH-FAT DIET. LIPOCALIN PROSTAGLANDIN D2 SYNTHASE (L-PGDS) FUNCTIONS AS A PROSTAGLANDIN SYNTHASE WHERE IT CATALYZES THE ISOMERIZATION OF PGH2 TO PGD2. PGD2 REGULATES ITS PHYSIOLOGICAL FUNCTION THROUGH TWO INDIVIDUAL G-PROTEIN COUPLED RECEPTORS NAMED DP1 AND DP2. THEREFORE, WE HYPOTHESIZED THAT THE LACK OF PGD2 WILL INDUCE FATTY LIVER DISEASE POSSIBLY INVOLVING HEPATIC INSULIN RESISTANCE AND OBESITY. THE OBJECTIVE OF THIS SURE FIRST APPLICATION IS TO INVESTIGATE THE ROLE OF L-PGDS AND ITS METABOLITE PGD2 IN NAFLD. AIM 1 OF THE CURRENT PROPOSAL IS DEDICATED ON ELUCIDATING THE EFFECT OF INSULIN SIGNALING ON L-PGDS MRNA AND PROTEIN EXPRESSION, LOCALIZATION, AND FUNCTION. NEXT, WE WILL BE INVESTIGATING THE ROLE OF L-PGDS ON GLUCOSE AND LIPID METABOLISM THROUGH STUDYING ENERGY SUBSTRATE UTILIZATION, GLYCOLYSIS, AND FATTY ACID OXIDATION. ADDITIONALLY, METABOLOMICS AND TRANSCRIPTOMICS UNBIASED APPROACHES WILL DISCOVER L-PGDS-REGULATED SIGNALING PATHWAYS IN NAFLD. AIM 3 IS DEDICATED TO DETERMINING THE ROLE OF PGD2 RECEPTOR MODULATORS, DP1 AND D2 RECEPTOR AGONIST AND ANTAGONIST, IN NAFLD USING INSULIN-RESISTANT HEPG2 CELLS AND DB/DB MICE SUBJECTED TO HIGH FAT DIET. THE SIGNIFICANCE OF THE PROPOSED RESEARCH IS THAT, ONCE HEPATIC REGULATION OF L-PGDS SIGNALING IS UNDERSTOOD, TARGETS FOR NAFLD PHARMACOTHERAPY COULD BE DEVELOPED. THIS WORK IS INNOVATIVE AS IT ELUCIDATES THE NOVEL ROLE OF L-PGDS IN FATTY LIVER DISEASE AND DEFINES ITS LINK TO INSULIN RESISTANCE AND OBESITY THAT IS SUPPORTED BY OUR PRELIMINARY DATA. COLLECTIVELY, OUR RESEARCH WILL SHED NEW LIGHT ON THE ROLE OF L-PGDS IN LIVER PHYSIOLOGY AND DIABETES- AND OBESITY-INDUCED NAFLD AND DISCOVER NEW THERAPEUTIC TARGETS FOR FUTURE STUDIES.

BILE ACID-MEDIATED OEA-PPARA SIGNALING IN FOOD INTAKE REGULATION - PROJECT SUMMARY/ABSTRACT MORE THAN HALF OF ADULTS ARE CONSIDERED OBESE OR OVERWEIGHT IN THE U.S. ONE IMPORTANT RISK FACTOR FOR OBESITY OR OVERWEIGHT IS CONSIDERED TO BE EXCESSIVE FOOD INTAKE. CURRENTLY, ONLY FIVE DRUGS ARE APPROVED BY FDA AS AN ANTI-OBESITY DRUG. HOWEVER, SOME ADVERSE EFFECTS HAVE BEEN REPORTED. THUS, A NOVEL APPROACH OR COMPLEMENTARY METHOD IS NECESSARY FOR OBESITY AND METABOLIC DISEASES. FOR THIS, MODULATION OF BILE ACIDS (BAS) IS EXPECTED TO BE A POTENTIAL APPROACH BECAUSE BAS ARE INVOLVED IN GLUCOSE HOMEOSTASIS AND ENERGY EXPENDITURE. PREVIOUSLY, WE REPORTED THAT BAS ACT NOT ONLY AS SIGNALING MOLECULES INVOLVED IN ENERGY EXPENDITURE AND GLUCOSE HOMEOSTASIS BUT ALSO AS REGULATORS OF FOOD INTAKE IN THE INTESTINE. THE STRUCTURE OF BAS, PARTICULARLY THE POSITION OF THE HYDROXYL GROUPS OF BAS IMPACTS FOOD INTAKE THROUGH INTESTINAL EFFECTS: (1) MODULATING THE ACTIVITY OF N-ACYL PHOSPHATIDYLETHANOLAMINE PHOSPHOLIPASE D (NAPE-PLD), WHICH PRODUCES THE ANOREXIGENIC BIOACTIVE LIPID OLEOYLETHANOLAMIDE (OEA), OR (2) REGULATING LIPID ABSORPTION AND THE GASTRIC EMPTYING-SATIATION PATHWAY. OUR PRELIMINARY DATA SHOW THAT 16Α-HYDROXYLATED BAS, PYTHOCHOLIC ACID INCREASED OEA AND DECREASED FOOD INTAKE IN MICE. HOWEVER, THE ROLE OF PYTHOCHOLIC ACID IN MAMMALS IS NOT COMPLETELY KNOWN BECAUSE 16Α-HYDROXYLATED BAS ARE NOT NATURALLY FOUND IN MAMMALS. WE WILL EXAMINE 1) A DETAILED HYPOPHAGIC MECHANISM OF PYTHOCHOLIC ACID, 2) THE INTERACTION BETWEEN 16Α-HYDROXYLATED BAS AND NAPE-PLD, AND 3) THE EFFECT OF 16Α- HYDROXYLATED BAS PRODUCING ENZYMES FOR MODIFICATION OF BA COMPOSITION IN MICE.

MULTIFAMILY HOUSING SERVICE COORDINATORS

REGULATION OF SPERM ACTIVATION IN C. ELEGANS - 1 CELL DIFFERENTIATION IS ACCOMPANIED BY MORPHOLOGICAL CHANGES AND DRIVEN BY DIFFERENTIAL 2 GENE EXPRESSION THROUGH TRANSCRIPTIONAL AND POST-TRANSCRIPTIONAL MECHANISMS. IN THE POST- 3 MEIOTIC SPERMATIDS, HOWEVER, TRANSCRIPTION IS REPRESSED, AND YET THE SPERMATIDS NEED TO 4 UNDERGO MORPHOLOGICAL CHANGES TO GAIN MOTILITY AND FERTILIZATION COMPETENCE. THIS PROCESS, 5 CALLED SPERMIOGENESIS, DEPENDS ON POST-TRANSCRIPTIONAL MECHANISMS. AS AN EXTREME EXAMPLE, 6 SPERMIOGENESIS IN THE NEMATODE C. ELEGANS (ALSO CALLED SPERM ACTIVATION), TAKES PLACE RAPIDLY 7 AND IS INDEPENDENT OF BOTH TRANSCRIPTION AND NEW PROTEIN SYNTHESIS. THIS PROCESS TRANSFORMS 8 SPHERICAL SPERMATIDS INTO POLARIZED AND MOTILE SPERMATOZOA WITH PSEUDOPODS AND ALLOWS THE 9 SPERM TO BE FERTILIZATION COMPETENT. HOW THE SPERMATIDS SENSE AND PROCESS THE SIGNALS TO 10 INITIATE SPERMIOGENESIS IS NOT WELL UNDERSTOOD. THE NEMATODE C. ELEGANS EXIST PRIMARILY AS SELF- 11 FERTILIZING HERMAPHRODITES, AND MALES THAT CAN MATE WITH HERMAPHRODITES. SPERM ACTIVATION IS 12 INITIATED BY INDEPENDENT BUT CONVERGING SIGNALING PATHWAYS IN HERMAPHRODITES VERSUS MALES. 13 THESE PATHWAYS INVOLVE SECRETED PROTEASES, TRANSMEMBRANE PROTEINS, KINASES, IRON 14 TRANSPORTERS, AND OTHER EFFECTOR PROTEINS. NOT ALL THE GENETIC REGULATORS ARE KNOWN; HOW THESE 15 REGULATORS WORK TOGETHER TO INDUCE CELLULAR CHANGES DURING ACTIVATION IS NOT WELL UNDERSTOOD. THE 16 LONG-TERM GOAL OF THIS APPLICATION IS TO UNDERSTAND THE GENETIC REGULATION OF GAMETE DEVELOPMENT 17 AND GAMETE FUNCTIONS. THE PROPOSED WORK HERE TAKES ADVANTAGES OF UNIQUE MUTANT ALLELES 18 ISOLATED IN A FORWARD MUTANT SCREENING FOR GENES THAT REGULATE GAMETE FUNCTION DURING 19 FERTILIZATION. TWO TEMPERATURE-SENSITIVE MUTANT ALLELES, AS47 AND AS48, BOTH SHOW A SHARP DROP 20 IN FERTILITY AND DEFECTS IN SPERM ACTIVATION IN VITRO. THE ALLELE AS47 AFFECTS A GENE ENCODING A 21 SER/THR PROTEIN PHOSPHATASE. THE OBJECTIVE OF THIS APPLICATION IS TO INVESTIGATE THE MOLECULAR 22 MECHANISM OF THE REGULATION OF SPERM ACTIVATION BY PHOSPHATASES AND TO IDENTIFY ADDITIONAL 23 REGULATORS. THIS OBJECTIVE WILL BE BROKEN DOWN TO THREE AIMS: 1), INVESTIGATE THE MECHANISMS BY 24 WHICH THE AFFECTED PHOSPHATASE IN AS47 REGULATES SPERM ACTIVATION. 2), INVESTIGATE THE ROLE OF A 25 RELATED SER/THR PHOSPHATASE IN SPERM ACTIVATION. IN BOTH AIM 1 AND 2, GENETIC ANALYSES AND A 26 CELLULAR BIOLOGICAL APPROACH WILL BE USED TO DISSECT THE RELATIONSHIP BETWEEN THESE PHOSPHATASES 27 AND KNOWN PATHWAYS OF SPERM ACTIVATION. 3), IDENTIFY AND EXPLORE THE FUNCTION OF THE GENE 28 AFFECTED IN AS48. THIS PROPOSED WORK WILL LEAD TO A BETTER UNDERSTANDING OF THE GENETIC REGULATION 29 OF SPERM DEVELOPMENT/DIFFERENTIATION. THE KNOWLEDGE GAINED FROM THIS APPLICATION WILL BE 30 APPLICABLE TO OTHER DEVELOPMENTAL CONTEXTS AND TO HIGH-ORDER ORGANISMS. 31

DLT OPIOID GRANTS

CAPITAL FUND PROGRAM

PFI-TT: DEVELOPING AN ARTIFICIAL INTELLIGENCE SOLUTION FOR ACCURATE MEDICAL CODING TO IMPROVE HEALTHCARE BILLING -THE BROADER IMPACT OF THIS PARTNERSHIPS FOR INNOVATION - TECHNOLOGY TRANSLATION (PFI-TT) PROJECT LIES IN OVERCOMING THE LIMITATIONS OF AUTOMATED BIOMEDICAL CONTENT ANNOTATION SYSTEMS, WHICH INCLUDE BIAS, ERRORS, AND A LACK OF ADAPTABILITY TO NEW INFORMATION. BY AUTOMATING AND OPTIMIZING THE MEDICAL CODING ASSIGNMENT PROCESS, THE PROJECT WILL ALLEVIATE ADMINISTRATIVE AND COGNITIVE BURDENS ON HEALTHCARE PROFESSIONALS, ALLOWING THEM TO FOCUS MORE TIME AND ATTENTION ON PATIENT CARE. THE SYSTEM WILL PROMOTE TRANSPARENCY, ACCOUNTABILITY, AND TRUSTWORTHINESS THROUGH A SOCIOTECHNICAL-BASED APPROACH, FOSTERING GREATER TRUST AND CONFIDENCE IN ARTIFICIAL INTELLIGENCE (AI) DRIVEN SYSTEMS WITHIN THE HEALTHCARE INDUSTRY. THIS INNOVATIVE SYSTEM WILL IMPROVE HEALTHCARE DELIVERY BY MINIMIZING CODING ERRORS AND ENSURING PRECISE REIMBURSEMENT CLAIMS, LEADING TO BETTER PATIENT OUTCOMES. THIS PROJECT HAS THE POTENTIAL TO ADVANCE SCIENTIFIC UNDERSTANDING OF AI APPLICATIONS IN HEALTHCARE AND POSITION ITSELF AS A LEADER IN THE GROWING HEALTHCARE TECHNOLOGY MARKET, FOSTERING BROADER ACCEPTANCE AND ADOPTION OF AI-DRIVEN SOLUTIONS. THIS PROJECT IS AT THE INTERSECTION OF AI, MEDICAL INFORMATICS, AND SOCIO-TECHNICAL SYSTEMS. THE PROJECT WILL FOCUS ON CREATING ROBUST ALGORITHMS FOR CONTEXT BUILDING FROM ELECTRONIC MEDICAL RECORDS (EMRS) AND A NOVEL AI FRAMEWORK TO ENHANCE ACCURACY. A KEY OBJECTIVE IS THE SEAMLESS INTEGRATION OF A SOCIO-TECHNICAL FEEDBACK LOOP THAT INCORPORATES INPUT FROM HEALTHCARE PROFESSIONALS TO REFINE AND OPTIMIZE THE SYSTEM'S RECOMMENDATIONS. THE RESEARCH AND DEVELOPMENT WILL INVOLVE THE INTEGRATION OF HETEROGENEOUS EMR DATA INTO A COMPREHENSIVE KNOWLEDGE GRAPH AND THE DEVELOPMENT OF AN AI FRAMEWORK THAT ITERATIVELY REFINES CODE RECOMMENDATIONS THROUGH A DYNAMIC RETRIEVER-GENERATOR INTERACTION. THE ANTICIPATED TECHNICAL RESULTS INCLUDE A HIGHLY ACCURATE AND TRUSTWORTHY MEDICAL CODING RECOMMENDATION SYSTEM. THIS USE-INSPIRED RESEARCH AIMS TO LEVERAGE THE COLLECTIVE INTELLIGENCE OF HUMANS AND MACHINES, ULTIMATELY IMPROVING THE PERFORMANCE AND RELIABILITY OF AUTOMATED MEDICAL CODING. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.

THE ROLE OF GENE DUPLICATION IN THE FLORAL SYMMETRY IN DIPSACALES

CONTINUUM OF CARE PROGRAM

PERFORM FUNDING SYS

PERFORM FUNDING SYS

PUBLIC AND INDIAN HOUSING

CAPITAL FUND PROGRAM

CAPITAL FUND PROGRAM

FY11 5309 SOGR - PUR.4 REPLACEMENT

ELUCIDATING THE FUNCTION OF P53-MEDIATED IL17RB REPRESSION - ABSTRACT IN ADDITION TO ITS PIVOTAL ROLES IN REGULATING CELL CYCLE ARREST, APOPTOSIS, DNA REPAIR, AND METABOLISM, THE P53 TUMOR SUPPRESSOR HAS BEEN DEMONSTRATED TO MODULATE INNATE IMMUNE AND ADAPTIVE IMMUNE RESPONSES THROUGH ITS CROSSTALK WITH KEY REGULATORS OF IMMUNE SIGNALING PATHWAYS. THE DYSREGULATION OF INTERLEUKIN 17 (IL17) CYTOKINE FAMILY AND ITS RECEPTORS HAS BEEN ASSOCIATED WITH MANY HUMAN DISEASES, NOTABLY INFLAMMATION AND CANCER, CREDITING TO THEIR CRUCIAL ROLES IN NORMAL HOST IMMUNE RESPONSES. PARTICULARLY, INTERLEUKIN 17 RECEPTOR B (IL17RB) HAS BEEN FOUND TO BE OVEREXPRESSED IN VARIOUS CANCERS THROUGH THE ACTIVATION OF NFB, AKT, OR ERK SIGNALING TO PROMOTE TUMORIGENESIS. OUR PRELIMINARY RESULTS INDICATE THAT IL17RB IS A P53 REPRESSION TARGET AND REPRESSION OF IL17RB SUSTAINS THE P53 RESPONSE. ADDITIONALLY, ACTIVATION OF P53 BY NUTLIN-3A OR IL17RB DEPLETION DECREASES THE EXPRESSION OF PRO-INFLAMMATORY CYTOKINE IL8 INDUCED BY LIPOPOLYSACCHARIDE (LPS). THE GOAL OF THIS APPLICATION IS TO STUDY THE ROLE OF P53-MEDIATED IL17RB REPRESSION IN TUMOR SUPPRESSION AND INFLAMMATION INHIBITION. WE ESTABLISHED SYSTEMS OF IL17RB REPRESSION, OVEREXPRESSION, AND ACTIVATION, THAT WILL ENABLE BIOCHEMICAL AND CELLULAR CHARACTERIZATION AS WELL AS IN-DEPTH GENE EXPRESSION ANALYSES TO ELUCIDATE THE CONTRIBUTION OF IL17RB REPRESSION TO TUMOR SUPPRESSIVE AND INFLAMMATION INHIBITORY FUNCTION OF P53. THE PROPOSED WORK WILL NOT ONLY ALLOW US TO GAIN A BETTER UNDERSTANDING ON HOW IL17RB LINKS P53’S CROSSTALK WITH OTHER SIGNALING PATHWAYS AND HOW P53 ATTENUATES ONCOGENIC EFFECTS OF CHRONIC INFLAMMATION THROUGH REPRESSING IL17RB, BUT ALSO PROVIDE A MECHANISTIC BASIS FOR THE DEVELOPMENT OF NOVEL ANTI-CANCER STRATEGIES AS WELL AS INFLAMMATION INHIBITORS. IN ADDITION, THIS PROJECT WILL ENHANCE THE RESEARCH ENVIRONMENT AT ST. JOHN’S UNIVERSITY BY PROVIDING UNDERGRADUATE AND GRADUATE STUDENTS WITH NUMEROUS OPPORTUNITIES TO LEARN THE FUNDAMENTALS OF BIOMEDICAL RESEARCH.

PUBLIC AND INDIAN HOUSING

PUBLIC AND INDIAN HOUSING

PUBLIC AND INDIAN HOUSING

WEST LAC DES ALLEMANDS SHORELINE PROTECTION

PERFORM FUNDING SYS

DEBRIS REMOVALFROM DRAINAGE CANALS (GOSHEN CANAL, LASSEIGNE CANAL, LEVEE CANA:, MARATHON CANA1, MCREINE CANAL <(>&<)> NW 3RD CANAL REACH 2. DAMAGE SURVEY REPORT 022_02_25_5056_007-012.

PUBLIC AND INDIAN HOUSING

INVESTIGATING THE MECHANISM REGULATING ALTERNATIVE SPLICING OF NEURAL AGIN: A NOVEL THERAPEUTIC ENTRY POINT FOR CONGENITAL MYASTHENIC SYNDROME

FATTY ALCOHOL SYNTHESIS AND VIRULENCE IN LEISHMANIA

FUNCTION AND REGULATION OF TRPP2, AND ITS ROLE IN ADPKD

TARGETING IKK AND HDAC MEDIATED IL-8 EXPRESSION IN OVARIAN AND PROSTATE CANCER

DESIGN AND DEVELOPMENT OF A NOVEL, THERMOSTABLE, AND INHALABLE DRY POWDER COVID-19 VACCINE - SUMMARY SEVERE ACUTE RESPIRATORY SYNDROME-CORONAVIRUS 2 (SARS-COV-2) IS A HIGHLY INFECTIOUS VIRUS KNOWN TO CAUSE THE 2019 CORONAVIRUS DISEASE (COVID-19). THE DISEASE HAS BEEN DECLARED AS A GLOBAL PANDEMIC BY THE WORLD HEALTH ORGANIZATION. IN THE UNITED STATES, AS OF JANUARY 20, 2021, WE HAVE MORE THAN 24 MILLION INFECTED INDIVIDUALS WITH APPROXIMATELY 400,000 DEATHS. COVID-19 APPEARS TO BE MORE DEADLY IN PATIENTS WITH CO-MORBIDITIES SUCH AS HYPERTENSION AND DIABETES AND PRESENTS MANY CLINICAL MANIFESTATIONS SUCH AS PNEUMONIA, DIARRHEA, MULTIPLE ORGAN FAILURE, ETC. AMONG THOSE INFECTED. MOREOVER, THE NUMBER OF INFECTIONS AND FATALITY RATE IS EXPECTED TO INCREASE SIGNIFICANTLY OVER THE NEXT FEW MONTHS, ACCORDING TO THE IHME MODEL. THERE IS AN URGENT GLOBAL NEED TO DEVELOP A THERMOSTABLE AND SELF-ADMINISTRABLE VACCINE. THE SPIKE PROTEIN ON THE SURFACE OF CORONAVIRUS IS AN EXCELLENT CANDIDATE FOR DEVELOPING VACCINES, HAS BEEN USED IN THE CURRENTLY EUA OBTAINED VACCINES, AS IT PLAYS AN IMPORTANT ROLE IN THE ENTRY OF THE VIRUS INTO THE HOST CELL. LIPOSOMES ARE EXCELLENT DRUG DELIVERY SYSTEMS THAT CAN PRESENT THE ANTIGEN AS PARTICULATE IN NATURE AND ALLOW THE INCORPORATION OF AN ADJUVANT THAT AIDS IN THE GENERATION OF A ROBUST IMMUNE RESPONSE. FURTHER, THE LIPOSOMES CAN BE DESIGNED TO BE OF SIMILAR SIZE TO THAT OF THE VIRUS AND THE SPIKE PROTEIN CAN BE CONJUGATED TO THE LIPOSOMAL SURFACE TO MIMIC THE NATURAL PRESENTATION ON THE VIRUS. THE IMMUNE CELLS WILL INTERNALIZE AND PROCESS THE ANTIGEN LIKE THE VIRUS AND GENERATE NEUTRALIZING ANTIBODY TITERS. MOST OF THE VACCINES CURRENTLY IN THE MARKET REQUIRE COLD CHAIN (REFRIGERATION) TO STORE AND DISTRIBUTE THE VACCINE TO MAINTAIN THE EFFICACY AND REQUIRE A VISIT TO THE CLINIC FOR IMMUNIZATION BY TRAINED MEDICAL PERSONNEL. THESE SERVE AS BOTTLENECKS IN ACHIEVING MASS VACCINATION IN A PANDEMIC ADDING FURTHER STRESS TO THE HOSPITALS AND THE SUPPLY CHAIN. IN ADDITION, A MAJOR LIMITATION IS THE LIMITED ABILITY OF EXISTING MANUFACTURING FACILITIES TO MANUFACTURE BILLIONS OF DOSES. IN THIS PROPOSAL, WE AIM TO DEVELOP A THERMOSTABLE AND INHALABLE DRY POWDER VACCINE THAT IS EASY TO SCALE-UP, ELIMINATES THE NEED FOR COLD-CHAIN STORAGE AND TRANSPORT, AND IS SELF-ADMINISTRABLE BY INDIVIDUALS’ AT-HOME BY SIMPLE INHALATION. TO ACHIEVE THIS GOAL, WE WILL PURSUE TWO AIMS: 1) FORMULATION OF AN INHALABLE AND THERMOSTABLE DRY POWDER COVID-19 VACCINE CONTAINING S PROTEIN-ADSORBED LIPOSOMAL CARRIERS AND 2) EVALUATION OF NEUTRALIZING MUCOSAL AND SYSTEMIC IGA AND IGG ANTIBODY TITERS AFTER AEROSOL ADMINISTRATION OF DRY POWDER COVID-19 VACCINE IN MICE. SUCCESSFUL COMPLETION OF THIS PROJECT WILL HAVE A PROFOUND IMPACT ON THE DEVELOPMENT OF DRY POWDER COVID-19 VACCINE, PARTICULARLY IN EXPLORING THERMOSTABLE AND INHALABLE VACCINES THAT ARE EASY TO MANUFACTURE, STORE, AND DISTRIBUTE, CHARACTERISTICS THAT ARE CRITICAL IN PANDEMIC.